Detailed information for compound 15965

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 554.505 | Formula: C29H35IN2O
  • H donors: 1 H acceptors: 0 LogP: 6.24 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccccc1CN[C@H]1C2CC[N+]([C@H]1C(c1ccccc1)c1ccccc1)(CC2)C.[I-]
  • InChi: 1S/C29H35N2O.HI/c1-31-19-17-24(18-20-31)28(30-21-25-15-9-10-16-26(25)32-2)29(31)27(22-11-5-3-6-12-22)23-13-7-4-8-14-23;/h3-16,24,27-30H,17-21H2,1-2H3;1H/q+1;/p-1/t24?,28-,29-,31?;/m0./s1
  • InChiKey: OYCLDODSLABJPF-FTQZKJBXSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tachykinin receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04224 tachykinin receptor 3, putative Get druggable targets OG5_137770 All targets in OG5_137770
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) inositol-1 0.0037 0.027 0.0269
Schistosoma mansoni tyrosine kinase 0.0015 0.0063 0.004
Schistosoma mansoni glutamate receptor NMDA 0.0015 0.0063 0.004
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0063 0.0062
Schistosoma mansoni ap endonuclease 0.0018 0.0092 0.0069
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0067 0.0044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0151 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0047 0.0367 0.0367
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.1061 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0592 0.057
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0311 0.0245
Loa Loa (eye worm) hypothetical protein 0.0071 0.0592 0.0591
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0039 0.0125
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0151 0.1011
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0067 0.0232
Onchocerca volvulus 0.0015 0.0063 0.0039
Loa Loa (eye worm) acetylcholinesterase 1 0.0065 0.0542 0.0541
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0129 0.1149 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0097 0.0074
Echinococcus granulosus nmda type glutamate receptor 0.0015 0.0063 0.01
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0097 0.0497
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0067 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.736 1
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.1061 1 1
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0129 0.1149 0.1127
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0043 0.0039
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0097 0.0097
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.1061 1 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0092 0.0473
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0129 0.1149 1
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.027 0.0366
Brugia malayi jmjC domain containing protein 0.0016 0.0067 0.0067
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.6252 0.6243
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0067 0.0258
Loa Loa (eye worm) hypothetical protein 0.0198 0.1802 0.1801
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.027 0.2064
Brugia malayi PAS domain containing protein 0.0048 0.0378 0.0378
Brugia malayi Metabotropic glutamate receptor precursor. 0.0161 0.1448 0.1448
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.04 0.0638
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0024
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0067 0.0044
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0015 0.0063 0.0085
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0378 0.0355
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0067 0.0044
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0151 0.1011
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.1149 0.1127
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0097 0.0074
Leishmania major DNA polymerase eta, putative 0.0019 0.0097 0.0522
Echinococcus granulosus acetylcholinesterase 0.0065 0.0542 0.0865
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0151 0.0084
Schistosoma mansoni gliotactin 0.0011 0.0025 0.0001
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.04 0.3252
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0592 0.0568
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0183 0.0182
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0198 0.1802 0.2447
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0129 0.1149 1
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0129 0.1149 0.1127
Loa Loa (eye worm) carboxylesterase 0.0065 0.0542 0.0541
Brugia malayi beta-lactamase family protein 0.0071 0.0592 0.0592
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0129 0.1149 0.1127
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0039 0.006
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0065 0.0542 0.0519
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0097 0.0153
Trypanosoma brucei Trans-2-enoyl-ACP reductase 1, putative 0.0047 0.0367 0.2937
Onchocerca volvulus 0.0082 0.0701 0.0678
Trypanosoma cruzi oxidoreductase, putative 0.0129 0.1149 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0092 0.0265
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0082 0.0701 0.0678
Loa Loa (eye worm) acetyltransferase 0.014 0.125 0.1249
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0146 0.1305 0.1305
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0474 0.0642
Brugia malayi Carboxylesterase family protein 0.0065 0.0542 0.0542
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.04 0.3336
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0129 0.1149 0.1127
Schistosoma mansoni protein kinase 0.0015 0.0063 0.004
Onchocerca volvulus Poor gastrulation protein homolog 0.0026 0.0168 0.0143
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0015 0.0063 0.0085
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0062
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0311 0.2545
Brugia malayi Carboxylesterase family protein 0.0011 0.0025 0.0025
Brugia malayi hypoxia-induced factor 1 0.0149 0.1338 0.1338
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0129 0.1149 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0082 0.011
Mycobacterium ulcerans dehydrogenase 0.0129 0.1149 0.1127
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.0025 0.0038
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0024
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0129 0.1149 0.1127
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.04 0.3252
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.027 0.2184
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.027 0.2184
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Brugia malayi MAP kinase sur-1 0.0051 0.04 0.04
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0311 0.0495
Leishmania major hypothetical protein, conserved 0.0047 0.0367 0.2956
Leishmania major zinc binding dehydrogenase-like protein 0.0129 0.1149 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.027 0.0247
Leishmania major DNA polymerase kappa, putative 0.0019 0.0097 0.0522
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0043 0.0039
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0024
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0039 0.0051
Trichomonas vaginalis esterase, putative 0.0071 0.0592 0.5045
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0015 0.0063 0.01
Echinococcus multilocularis acetylcholinesterase 0.0065 0.0542 0.0734
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0129 0.1149 0.1127
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.04 0.3336
Loa Loa (eye worm) glutamate receptor 0.0063 0.0521 0.052
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0039 0.5
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.125 0.1229
Toxoplasma gondii ABC1 family protein 0.0071 0.0592 0.0528
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.1061 1 1
Onchocerca volvulus 0.0071 0.0592 0.0568
Echinococcus granulosus glutamate receptor 2 0.0015 0.0063 0.01
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0097 0.0072
Echinococcus granulosus dna polymerase eta 0.0019 0.0097 0.0153
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0038
Toxoplasma gondii type I fatty acid synthase, putative 0.0129 0.1149 0.1089
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.027 0.1685
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0129 0.1149 0.1836
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0129 0.1149 0.1149
Schistosoma mansoni quinone oxidoreductase 0.0047 0.0367 0.0344
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0039 0.0125
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0097 0.0522
Mycobacterium tuberculosis Possible dehydrogenase 0.0129 0.1149 0.1127
Brugia malayi jmjC domain containing protein 0.006 0.0489 0.0489
Mycobacterium leprae Probable oxidireductase 0.0129 0.1149 0.1114
Schistosoma mansoni acetylcholinesterase 0.0011 0.0025 0.0001
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0097 0.0074
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0311 0.2545
Leishmania major protein kinase, putative 0.0013 0.0043 0.0039
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0092 0.0482
Trypanosoma cruzi oxidoreductase, putative 0.0047 0.0367 0.2956
Onchocerca volvulus 0.0071 0.0592 0.0568
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0067 0.0106
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0129 0.1149 0.1127
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0129 0.1149 0.1127
Mycobacterium ulcerans oxidoreductase 0.0129 0.1149 0.1127
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0015 0.0063 0.0085
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0097 0.0641
Schistosoma mansoni alcohol dehydrogenase 0.1061 1 1
Onchocerca volvulus 0.0013 0.0039 0.0014
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0039 0.0125
Brugia malayi Receptor family ligand binding region containing protein 0.0041 0.0311 0.0311
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0233 0.0209
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0129 0.1149 1
Brugia malayi Carboxylesterase family protein 0.0011 0.0025 0.0025
Echinococcus multilocularis nmda type glutamate receptor 0.0015 0.0063 0.0085
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.0025 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0039 0.0125
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0129 0.1149 0.1127
Leishmania major d-xylulose reductase, putative 0.0129 0.1149 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0489 0.0467
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.027 0.1906
Onchocerca volvulus 0.0036 0.0259 0.0235
Echinococcus granulosus synaptic vesicle membrane protein VAT 1 0.0047 0.0367 0.0585
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0151 0.3963
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0097 0.0307
Loa Loa (eye worm) hypothetical protein 0.0071 0.0592 0.0591
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.0025 0.0038
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0092 0.0456
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0367 0.2956
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0082 0.0701 0.0701
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0097 0.0497
Brugia malayi jmjC domain containing protein 0.0016 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0062
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0129 0.1149 0.1127
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0097 0.0522
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Mycobacterium ulcerans lipase LipD 0.0071 0.0592 0.0568
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0097 0.0072
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0129 0.1149 1
Schistosoma mansoni hypothetical protein 0.0332 0.3071 0.3055
Loa Loa (eye worm) hypothetical protein 0.0071 0.0592 0.0591
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.04 0.0377
Brugia malayi Carboxylesterase family protein 0.0011 0.0025 0.0025
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0129 0.1149 0.1127
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.1212 0.1938
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0474 0.0756
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0067 0.0106
Loa Loa (eye worm) acyl carrier protein 0.0082 0.0701 0.07
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0097 0.0522
Echinococcus granulosus metabotropic glutamate receptor 5 0.0198 0.1802 0.2881
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0129 0.1149 0.1559
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0026 0.0168 0.0143
Echinococcus multilocularis GPCR, family 3, C terminal 0.0026 0.0168 0.0226
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0097 0.0497
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0067 0.0066
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0015 0.0063 0.0085
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.04 0.0542
Leishmania major quinone oxidoreductase, putative 0.0129 0.1149 1
Brugia malayi Inositol-1 0.0037 0.027 0.027
Echinococcus granulosus receptor type guanylyl cyclase 0.0015 0.0063 0.01
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0063 0.0062
Loa Loa (eye worm) hypothetical protein 0.0071 0.0592 0.0591
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0097 0.0522
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0129 0.1149 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0592 0.0568
Leishmania major zinc-binding dehydrogenase-like protein 0.0082 0.0701 0.597
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0129 0.1149 0.1149
Loa Loa (eye worm) oxidoreductase 0.0047 0.0367 0.0366
Giardia lamblia DINP protein human, muc B family 0.0019 0.0097 0.0147
Brugia malayi metabotropic glutamate receptor type 2 0.0078 0.0665 0.0665
Echinococcus multilocularis carboxylesterase 5A 0.0065 0.0542 0.0734
Mycobacterium ulcerans polyketide synthase 0.0129 0.1149 0.1127
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0592 0.0592
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0092 0.06
Leishmania major hypothetical protein, conserved 0.0071 0.0592 0.4983
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0067 0.0258
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0062
Echinococcus granulosus acetylcholinesterase 0.0065 0.0542 0.0865
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0129 0.1149 0.1114
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.0025 0.0038
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0259 0.035
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0592 1
Loa Loa (eye worm) hypothetical protein 0.0162 0.1457 0.1456
Echinococcus granulosus single minded 2 0.0036 0.0259 0.0412
Loa Loa (eye worm) hypothetical protein 0.0026 0.0168 0.0167
Onchocerca volvulus Fatty acid synthase homolog 0.0082 0.0701 0.0678
Mycobacterium tuberculosis Conserved protein 0.0071 0.0592 0.0568
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0092 0.06
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0025 0.0001
Mycobacterium ulcerans quinone oxidoreductase 0.0129 0.1149 0.1127
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0129 0.1149 0.1127
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.04 0.0335
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0129 0.1149 0.1127
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0097 0.0522
Schistosoma mansoni single-minded 0.0048 0.0378 0.0355
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0474 0.0642
Trypanosoma brucei oxidoreductase, putative 0.0129 0.1149 1
Mycobacterium tuberculosis Possible dehydrogenase 0.0129 0.1149 0.1127
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.0025 0.0001
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0039 0.006
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.0025 0.0032
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0129 0.1149 0.1127
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0015 0.0063 0.0062
Toxoplasma gondii type I fatty acid synthase 0.0047 0.0367 0.0302
Leishmania major hypothetical protein, conserved 0.0024 0.0151 0.1011
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Mycobacterium ulcerans hypothetical protein 0.0071 0.0592 0.0568
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.04 0.3252
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.027 0.2184
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0047 0.0367 0.0343
Loa Loa (eye worm) hypothetical protein 0.0082 0.0701 0.07
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0043 0.0039
Loa Loa (eye worm) hypothetical protein 0.0065 0.0542 0.0541
Brugia malayi Carboxylesterase family protein 0.0065 0.0542 0.0542
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0452 0.4214 0.42
Echinococcus multilocularis receptor type guanylyl cyclase 0.0015 0.0063 0.0085
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0592 0.0568
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.04 0.3336
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0592 0.057
Schistosoma mansoni cpg binding protein 0.0029 0.0198 0.0175
Loa Loa (eye worm) hypothetical protein 0.0129 0.1149 0.1148
Echinococcus multilocularis acetylcholinesterase 0.0065 0.0542 0.0734
Onchocerca volvulus 0.0028 0.0183 0.0159
Trypanosoma cruzi oxidoreductase, putative 0.0082 0.0701 0.597
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0097 0.0522
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.04 0.3252
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0129 0.1149 1
Leishmania major hypothetical protein, conserved 0.0047 0.0367 0.2956
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0592 0.0945
Mycobacterium tuberculosis Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0932 0.8771 0.8768
Brugia malayi beta-lactamase 0.0071 0.0592 0.0592
Echinococcus granulosus microtubule associated protein 2 0.0667 0.6252 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0092 0.0068
Loa Loa (eye worm) cytochrome P450 family protein 0.0044 0.0335 0.0334
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0092 0.0092
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0013 0.0039 0.0125
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0129 0.1149 0.1127
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.027 0.0246
Schistosoma mansoni zinc binding dehydrogenase 0.0129 0.1149 0.1128
Schistosoma mansoni cpg binding protein 0.0029 0.0198 0.0175
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.125 0.125
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0129 0.1149 1
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0067 0.0044
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.027 0.2086
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0592 0.5045
Echinococcus granulosus geminin 0.0332 0.3071 0.4911
Echinococcus granulosus tyrosine kinase 0.0015 0.0063 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0592 0.0568
Leishmania major extracellular receptor, putative 0.0015 0.0063 0.0222
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0129 0.1149 0.1127
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0025 0.0001
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.027 0.0204
Mycobacterium leprae Probable lipase LipE 0.0071 0.0592 0.0555
Schistosoma mansoni hypothetical protein 0.0332 0.3071 0.3055
Loa Loa (eye worm) hypothetical protein 0.0016 0.0067 0.0066
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0592 0.5045
Trypanosoma cruzi quinone oxidoreductase, putative 0.0047 0.0367 0.2956
Mycobacterium leprae Probable polyketide synthase Pks1 0.0129 0.1149 0.1114
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0278 0.6047
Loa Loa (eye worm) glutamate receptor 0.0161 0.1448 0.1448
Onchocerca volvulus 0.0129 0.1149 0.1127
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0097 0.0072
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0067 0.0106
Trypanosoma brucei protein kinase, putative 0.0051 0.04 0.3234
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0129 0.1149 0.1127
Mycobacterium ulcerans oxidoreductase FadB5 0.0129 0.1149 0.1127
Echinococcus granulosus metabotropic glutamate receptor 2 0.0135 0.12 0.1919
Echinococcus granulosus dna polymerase kappa 0.0019 0.0097 0.0153
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0592 0.0591
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0039 0.0051
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0478 0.0456
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0082 0.0701 0.0701
Loa Loa (eye worm) hypothetical protein 0.0016 0.0067 0.0066
Leishmania major oxidoreductase-like protein 0.0129 0.1149 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0129 0.1149 1
Echinococcus multilocularis geminin 0.0332 0.3071 0.4171
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0023 0.003
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0043 0.0039
Echinococcus granulosus phd:f box containing protein 0.0016 0.0067 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0592 0.4983
Brugia malayi jmjC domain containing protein 0.0016 0.0067 0.0067
Onchocerca volvulus 0.0071 0.0592 0.0568
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0023 0.0036
Echinococcus multilocularis glutamate receptor 2 0.0015 0.0063 0.0085
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0129 0.1149 1
Echinococcus multilocularis glutamate receptor 2 0.0015 0.0063 0.0085
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0067 0.0044
Schistosoma mansoni ap endonuclease 0.0018 0.0092 0.0069
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0592 0.0555
Leishmania major oxidoreductase, putative 0.0129 0.1149 1
Loa Loa (eye worm) carboxylesterase 0.0011 0.0025 0.0024
Echinococcus granulosus cpg binding protein 0.0029 0.0198 0.0315
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0062
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0067 0.009
Schistosoma mansoni tyrosine kinase 0.0015 0.0063 0.004
Brugia malayi beta-lactamase family protein 0.0071 0.0592 0.0592
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0082 0.0701 0.5959
Mycobacterium ulcerans quinone reductase Qor 0.0129 0.1149 0.1127
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.6252 0.8494
Brugia malayi CXXC zinc finger family protein 0.0028 0.0183 0.0183
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.1061 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0097 0.0072
Echinococcus granulosus carboxylesterase 5A 0.0065 0.0542 0.0865
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0592 0.0803
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0311 0.4641
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.0096
Echinococcus multilocularis dna polymerase eta 0.0019 0.0097 0.013
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0151 0.3963
Loa Loa (eye worm) beta-lactamase 0.0071 0.0592 0.0591
Toxoplasma gondii quinone oxidoreductase, putative 0.0129 0.1149 0.1089
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0024
Echinococcus multilocularis synaptic vesicle membrane protein VAT 1 0.0047 0.0367 0.0497
Loa Loa (eye worm) carboxylesterase 0.0011 0.0025 0.0024
Brugia malayi hypothetical protein 0.0016 0.0069 0.0069
Echinococcus multilocularis tyrosine kinase 0.0015 0.0063 0.0085
Brugia malayi hypothetical protein 0.0015 0.0063 0.0063
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0015 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0016 0.0067 0.0066
Mycobacterium ulcerans beta-lactamase 0.0071 0.0592 0.0568
Trypanosoma cruzi extracellular receptor, putative 0.0015 0.0063 0.0222
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0039 0.0125
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0129 0.1149 1
Mycobacterium ulcerans alcohol dehydrogenase AdhA 0.0047 0.0367 0.0343
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.04 0.3252
Loa Loa (eye worm) hypothetical protein 0.0129 0.1149 0.1148
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0278 0.1979
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.04 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0129 0.1149 0.1127
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0129 0.1149 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0092 0.0068
Brugia malayi hypothetical protein 0.0162 0.1457 0.1457
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 0.0932 0.8771 0.8768
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0151 0.1593
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0592 0.5045
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0097 0.013
Echinococcus granulosus atrial natriuretic peptide receptor 0.0015 0.0063 0.01
Schistosoma mansoni metabotropic glutamate receptor 0.0078 0.0665 0.0643
Echinococcus granulosus GPCR family 3 C terminal 0.0026 0.0168 0.0267
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0129 0.1149 0.1114
Mycobacterium ulcerans oxidoreductase 0.0082 0.0701 0.0678
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0015 0.0063 0.01
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0592 0.0568
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0092 0.5
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0592 0.0568
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.04 0.3234
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.04 0.0638
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.0025 0.0032
Trypanosoma brucei oxidoreductase, putative 0.0129 0.1149 1
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.1061 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0024
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0092 0.0482
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0041 0.0311 0.031
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0489 0.0488
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0129 0.1149 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0067 0.009
Echinococcus multilocularis cpg binding protein 0.0029 0.0198 0.0268
Trypanosoma brucei unspecified product 0.0019 0.0097 0.0497
Loa Loa (eye worm) hypothetical protein 0.0071 0.0592 0.0591
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0039 0.0125
Loa Loa (eye worm) hypoxia-induced factor 1 0.0149 0.1338 0.1337
Leishmania major hypothetical protein, conserved 0.0016 0.0067 0.0258
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0474 0.0451
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0129 0.1149 0.1114
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0592 0.0568
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0024
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0067 0.009
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0489 0.078
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0311 0.0245
Loa Loa (eye worm) hypothetical protein 0.0129 0.1149 0.1148
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0259 0.0259
Echinococcus granulosus glutamate receptor 2 0.0015 0.0063 0.01
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0097 0.0096
Brugia malayi jmjC domain containing protein 0.0016 0.0067 0.0067
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0129 0.1149 0.1127
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0062
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0092 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0592 0.0568
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0039 0.0038
Brugia malayi Carboxylesterase family protein 0.0011 0.0025 0.0025
Mycobacterium tuberculosis Conserved protein 0.0071 0.0592 0.0568
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0063 0.0062
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0092 0.0146
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0233 0.0196
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.027 0.043
Brugia malayi Receptor family ligand binding region containing protein 0.0015 0.0063 0.0063
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0592 0.5045
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0278 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0015 0.0063 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0592 0.4983
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0092 0.1177
Brugia malayi Guanylyl cyclase protein 23 0.0015 0.0063 0.0063
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0129 0.1149 0.1114
Schistosoma mansoni inositol monophosphatase 0.0037 0.027 0.0247
Echinococcus multilocularis neuroligin 0.0011 0.0025 0.0032
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0592 0.0568
Schistosoma mansoni metabotropic glutamate receptor 0.0135 0.12 0.118
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0451 0.0387
Mycobacterium ulcerans quinone oxidoreductase 0.0129 0.1149 0.1127
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.04 0.0399
Toxoplasma gondii exonuclease III APE 0.0018 0.0092 0.0025
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0129 0.1149 0.1127
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0592 0.5045
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0592 0.4969
Echinococcus granulosus neuroligin 0.0011 0.0025 0.0038
Onchocerca volvulus 0.0015 0.0063 0.0039
Brugia malayi jmjC domain containing protein 0.0058 0.0474 0.0474
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.1061 1 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0015 0.0063 0.01
Brugia malayi hypothetical protein 0.0011 0.0025 0.0025
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0097 0.0497
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0067 0.0066
Mycobacterium ulcerans oxidoreductase 0.0047 0.0367 0.0343
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0183 0.1658 0.1639
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.027 0.2086
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0092 0.0482
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0151 0.0986
Onchocerca volvulus Putative alcohol dehydrogenase 0.1061 1 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0082 0.013
Trypanosoma cruzi oxidoreductase, putative 0.0129 0.1149 1
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0259 0.0235
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0097 0.013
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0026 0.0168 0.0168
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0092 0.0124
Trichomonas vaginalis adenylate cyclase, putative 0.0013 0.0039 0.0125
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.04 0.3252
Brugia malayi hypothetical protein 0.0024 0.0151 0.0151
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0015 0.0063 0.0085
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0041 0.0311 0.031
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0097 0.0641
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.027 0.2086
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.04 0.0542
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0041 0.0311 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0039 0.0125
Trypanosoma cruzi quinone oxidoreductase, putative 0.0047 0.0367 0.2956
Loa Loa (eye worm) alcohol dehydrogenase class III 0.1061 1 1
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0135 0.12 0.163
Loa Loa (eye worm) hypothetical protein 0.0071 0.0592 0.0591
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0024
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0067 0.0066
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0013 0.0039 0.0125
Leishmania major protein kinase, putative 0.0013 0.0043 0.0039
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.125 0.1696
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0025 0.0001
Schistosoma mansoni hypothetical protein 0.0026 0.0168 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0039 0.0125
Leishmania major quinone oxidoreductase-like protein,alcohol dehydrogenase, zinc-containing-like protein 0.0047 0.0367 0.2956
Leishmania major nuclear receptor binding factor-like protein 0.0082 0.0701 0.597
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0129 0.1149 0.1127
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.0025 0.0032
Mycobacterium tuberculosis Conserved protein 0.0071 0.0592 0.0568
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0129 0.1149 0.1127
Schistosoma mansoni cpg binding protein 0.0028 0.0183 0.016
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0489 0.0467
Brugia malayi Cytochrome P450 family protein 0.0044 0.0335 0.0335
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0015 0.0063 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0097 0.0497
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0062
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.1061 1 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0542 0.0541
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.04 0.3336
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0062

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 12.2 nM Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]-Bolton-Hunter substance p from human IM-9 cells ChEMBL. No reference
IC50 (binding) = 12.2 nM Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]-Bolton-Hunter substance p from human IM-9 cells ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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