TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 437.53 | Formula: C29H27NO3
H donors: 0 H acceptors: 2 LogP: 7.21 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)c1ccc(cc1C1(CCCC1)c1ccccc1)OCc1ccc2c(n1)cccc2
InChi: 1S/C29H27NO3/c1-32-28(31)25-16-15-24(33-20-23-14-13-21-9-5-6-12-27(21)30-23)19-26(25)29(17-7-8-18-29)22-10-3-2-4-11-22/h2-6,9-16,19H,7-8,17-18,20H2,1H3
InChiKey: DASDYORBZDTLTM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	arachidonate 5-lipoxygenase-activating protein	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0105	0.0204	0.0631
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0355	0.176	0.5444
Echinococcus multilocularis	calpain 7 (C02 family)	0.0401	0.2051	0.2051
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0355	0.176	0.5444
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0401	0.2051	0.2051
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0204	0.0025
Brugia malayi	calpain 5	0.0115	0.0266	0.0088
Onchocerca volvulus		0.0355	0.176	0.4373
Onchocerca volvulus		0.0355	0.176	0.4373
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0105	0.0204	0.0129
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0355	0.176	0.5444
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0254	0.1129	0.3493
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0355	0.176	0.5444
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0355	0.176	0.5444
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0115	0.0266	0.0266
Trypanosoma cruzi	cysteine peptidase, putative	0.0355	0.176	0.176
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0355	0.176	0.5444
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0591	0.3234	0.311
Brugia malayi	Cathepsin L-like precursor	0.0355	0.176	0.1609
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0401	0.2051	0.6343
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0115	0.0266	0.0266
Onchocerca volvulus		0.0254	0.1129	0.26
Onchocerca volvulus	Cathepsin L homolog	0.0355	0.176	0.4373
Plasmodium vivax	calpain, putative	0.0401	0.2051	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0355	0.176	0.5444
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0355	0.176	0.5444
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0115	0.0266	0.0266
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0105	0.0204	0.0025
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0115	0.0266	0.0266
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0401	0.2051	0.6015
Leishmania major	cathepsin L-like protease	0.0355	0.176	0.5035
Schistosoma mansoni	cathepsin S (C01 family)	0.0105	0.0204	0.0025
Echinococcus multilocularis	calpain	0.0401	0.2051	0.2051
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0355	0.176	0.176
Loa Loa (eye worm)	cysteine protease	0.0355	0.176	0.1609
Echinococcus multilocularis	microsomal glutathione S transferase 3	0.0135	0.0391	0.0391
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0105	0.0204	0.0025
Trypanosoma cruzi	cysteine proteinase, putative	0.0206	0.0835	0.0835
Brugia malayi	cathepsin L precursor	0.0105	0.0204	0.0025
Leishmania major	cathepsin L-like protease	0.0355	0.176	0.5035
Loa Loa (eye worm)	hypothetical protein	0.1077	0.6265	0.6197
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0355	0.176	0.5444
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0206	0.0835	0.2582
Leishmania major	kinesin, putative	0.0286	0.1334	0.3599
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0401	0.2051	0.2051
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0105	0.0204	0.0631
Loa Loa (eye worm)	hypothetical protein	0.0791	0.448	0.4379
Brugia malayi	calpain 7	0.0401	0.2051	0.1906
Loa Loa (eye worm)	calpain family protein 1	0.0791	0.448	0.4379
Entamoeba histolytica	cysteine proteinase, putative	0.0254	0.1129	0.6416
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0355	0.176	0.5444
Schistosoma mansoni	calpain (C02 family)	0.0401	0.2051	0.1906
Trypanosoma brucei	calpain, putative	0.0115	0.0266	0.0823
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0115	0.0266	0.0266
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1676	1	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0254	0.1129	0.0967
Toxoplasma gondii	MAPEG family protein	0.0135	0.0391	0.0618
Plasmodium vivax	vivapain-3	0.0206	0.0835	0.3501
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.0204	0.0631
Entamoeba histolytica	cysteine proteinase, putative	0.0206	0.0835	0.4743
Echinococcus multilocularis	cathepsin L	0.0105	0.0204	0.0204
Entamoeba histolytica	cysteine protease, putative	0.0206	0.0835	0.4743
Entamoeba histolytica	protein kinase, putative	0.0286	0.1334	0.7578
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0401	0.2051	0.2051
Loa Loa (eye worm)	calpain D	0.0115	0.0266	0.0088
Entamoeba histolytica	cysteine protease, putative	0.0105	0.0204	0.1159
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0115	0.0266	0.0266
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1676	1	1
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0115	0.0266	0.0823
Trypanosoma brucei	kinesin, putative	0.0286	0.1334	0.4125
Brugia malayi	Papain family cysteine protease containing protein	0.0355	0.176	0.1609
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0105	0.0204	0.0129
Echinococcus multilocularis	cysteine protease	0.0355	0.176	0.176
Entamoeba histolytica	cysteine proteinase 2	0.0206	0.0835	0.4743
Brugia malayi	Papain family cysteine protease containing protein	0.0105	0.0204	0.0025
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0355	0.176	0.5444
Trypanosoma brucei	calpain, putative	0.0115	0.0266	0.0823
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0105	0.0204	0.0025
Plasmodium vivax	serine-repeat antigen (SERA)	0.0105	0.0204	0.0129
Entamoeba histolytica	cysteine protease, putative	0.0105	0.0204	0.1159
Schistosoma mansoni	membrane associated proteins in eicosanoid and glutathione metabolism family member	0.0135	0.0391	0.0215
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0355	0.176	0.5444
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0115	0.0266	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0204	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0204	0.0025
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0115	0.0266	0.0266
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0401	0.2051	0.6015
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0115	0.0266	0.0266
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0355	0.176	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0105	0.0204	0.0631
Plasmodium vivax	serine-repeat antigen (SERA)	0.0105	0.0204	0.0129
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0355	0.176	0.5444
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0355	0.176	0.5444
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0105	0.0204	0.0025
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0206	0.0835	0.2582
Leishmania major	cathepsin L-like protease	0.0355	0.176	0.5035
Onchocerca volvulus		0.0355	0.176	0.4373
Trypanosoma cruzi	cruzipain precursor, putative	0.0355	0.176	0.176
Loa Loa (eye worm)	hypothetical protein	0.0254	0.1129	0.0967
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0401	0.2051	0.6015
Brugia malayi	Cathepsin L-like precursor	0.0355	0.176	0.1609
Entamoeba histolytica	cysteine protease, putative	0.0206	0.0835	0.4743
Echinococcus multilocularis	cathepsin L cysteine protease	0.0355	0.176	0.176
Echinococcus multilocularis	hypothetical protein	0.0401	0.2051	0.2051
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0401	0.2051	0.2051
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0355	0.176	0.5444
Trichomonas vaginalis	calpain, putative	0.0115	0.0266	0.0823
Entamoeba histolytica	cysteine protease, putative	0.0105	0.0204	0.1159
Plasmodium vivax	unspecified product	0.0105	0.0204	0.0129
Toxoplasma gondii	cathepsin CPL	0.0355	0.176	0.5137
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0115	0.0266	0.0266
Entamoeba histolytica	cysteine protease, putative	0.0105	0.0204	0.1159
Trypanosoma brucei	Calpain-like protein 1.2	0.0115	0.0266	0.0823
Trypanosoma cruzi	cysteine peptidase, putative	0.0355	0.176	0.176
Brugia malayi	cathepsin F-like cysteine proteinase	0.0105	0.0204	0.0025
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0105	0.0204	0.0025
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0105	0.0204	0.0129
Trypanosoma cruzi	cysteine peptidase, putative	0.0101	0.018	0.018
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0105	0.0204	0.0631
Leishmania major	cathepsin L-like protease	0.0355	0.176	0.5035
Brugia malayi	Papain family cysteine protease containing protein	0.0206	0.0835	0.0667
Brugia malayi	calpain family protein 1	0.1077	0.6265	0.6197
Loa Loa (eye worm)	calpain family protein 1	0.1077	0.6265	0.6197
Echinococcus granulosus	cathepsin l1	0.0254	0.1129	0.1129
Entamoeba histolytica	cysteine proteinase, putative	0.0206	0.0835	0.4743
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0355	0.176	0.5444
Echinococcus multilocularis	calpain 5	0.0401	0.2051	0.2051
Schistosoma mansoni	cathepsin F (C01 family)	0.0254	0.1129	0.0967
Trichomonas vaginalis	calpain, putative	0.0115	0.0266	0.0823
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0105	0.0204	0.0129
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0355	0.176	0.5444
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0105	0.0204	0.0025
Loa Loa (eye worm)	calpain	0.0401	0.2051	0.1906
Loa Loa (eye worm)	ctsf protein	0.0355	0.176	0.1609
Trypanosoma cruzi	kinesin, putative	0.0286	0.1334	0.1334
Echinococcus granulosus	calpain	0.0401	0.2051	0.2051
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0115	0.0266	0.0266
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0105	0.0204	0.0631
Echinococcus multilocularis	calpain family protein 1, d	0.0791	0.448	0.448
Entamoeba histolytica	cysteine protease, putative	0.0206	0.0835	0.4743
Brugia malayi	Cathepsin L-like precursor	0.0355	0.176	0.1609
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0355	0.176	0.5444
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0355	0.176	0.5444
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0401	0.2051	0.2051
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.1146	0.6695	0.6695
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0105	0.0204	0.0129
Schistosoma mansoni	calpain C (C02 family)	0.0401	0.2051	0.1906
Entamoeba histolytica	cysteine protease, putative	0.0206	0.0835	0.4743
Entamoeba histolytica	cysteine proteinase, putative	0.0355	0.176	1
Entamoeba histolytica	cysteine protease, putative	0.0206	0.0835	0.4743
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0105	0.0204	0.1159
Trypanosoma cruzi	kinesin, putative	0.0286	0.1334	0.1334
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0206	0.0835	0.2582
Schistosoma mansoni	cathepsin F (C01 family)	0.0355	0.176	0.1609
Entamoeba histolytica	cysteine proteinase, putative	0.0206	0.0835	0.4743
Entamoeba histolytica	cysteine protease, putative	0.0206	0.0835	0.4743
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.1146	0.6695	0.6634
Echinococcus granulosus	cysteine protease	0.0206	0.0835	0.0835
Leishmania major	cathepsin L-like protease	0.0355	0.176	0.5035
Onchocerca volvulus		0.0355	0.176	0.4373
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0105	0.0204	0.0129
Trichomonas vaginalis	conserved hypothetical protein	0.0105	0.0204	0.0631
Trypanosoma cruzi	cruzipain precursor, putative	0.0101	0.018	0.018
Loa Loa (eye worm)	cathepsin B	0.0591	0.3234	0.311
Echinococcus granulosus	calpain 5	0.0401	0.2051	0.2051
Entamoeba histolytica	cysteine protease, putative	0.0105	0.0204	0.1159
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0355	0.176	0.1609
Brugia malayi	Papain family cysteine protease containing protein	0.0105	0.0204	0.0025
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0401	0.2051	0.2051
Trypanosoma cruzi	cysteine protease, putative	0.0206	0.0835	0.0835
Onchocerca volvulus		0.0355	0.176	0.4373
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0355	0.176	0.5444
Toxoplasma gondii	cathepsin B	0.0591	0.3234	1
Entamoeba histolytica	cysteine protease, putative	0.0105	0.0204	0.1159
Entamoeba histolytica	cysteine protease, putative	0.0206	0.0835	0.4743
Onchocerca volvulus		0.0676	0.3763	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1676	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.0204	0.0631
Trypanosoma cruzi	cysteine peptidase, putative	0.0355	0.176	0.176
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0105	0.0204	0.0129
Trypanosoma brucei	hypothetical protein	0.0115	0.0266	0.0823
Giardia lamblia	Cathepsin B precursor	0.0591	0.3234	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0105	0.0204	0.0631
Onchocerca volvulus	Cathepsin F homolog	0.0355	0.176	0.4373
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0105	0.0204	0.0631
Trypanosoma brucei	calpain-like protein, putative	0.0401	0.2051	0.6343
Trypanosoma brucei	cytoskeleton-associated protein CAP5.5, putative	0.0115	0.0266	0.0823
Trichomonas vaginalis	hypothetical protein	0.0115	0.0266	0.0823
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0355	0.176	0.5444
Brugia malayi	Cathepsin L-like precursor	0.0254	0.1129	0.0967
Entamoeba histolytica	cysteine protease, putative	0.0206	0.0835	0.4743
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0591	0.3234	0.3234
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0105	0.0204	0.0631
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0105	0.0204	0.0025
Schistosoma mansoni	cathepsin B (C01 family)	0.0105	0.0204	0.0025
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0401	0.2051	0.2051
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0355	0.176	1
Echinococcus granulosus	calpain A	0.0401	0.2051	0.2051
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0266	0.0088
Plasmodium vivax	unspecified product	0.0206	0.0835	0.3501
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1676	1	1
Entamoeba histolytica	calpain family cysteine protease, putative	0.0115	0.0266	0.1512
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0355	0.176	0.5444
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0355	0.176	0.5444
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0105	0.0204	0.0129
Entamoeba histolytica	cysteine proteinase 1, putative	0.0206	0.0835	0.4743
Loa Loa (eye worm)	fibroinase	0.0355	0.176	0.1609
Loa Loa (eye worm)	hypothetical protein	0.0254	0.1129	0.0967
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0355	0.176	0.5444
Plasmodium vivax	vivapain-1	0.0206	0.0835	0.3501
Loa Loa (eye worm)	hypothetical protein	0.0254	0.1129	0.0967
Echinococcus multilocularis	cathepsin L cysteine protease	0.0355	0.176	0.176
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0105	0.0204	0.0025
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0355	0.176	0.5444
Toxoplasma gondii	calpain family cysteine protease domain-containing protein	0.0115	0.0266	0.0205
Leishmania major	cathepsin L-like protease	0.0355	0.176	0.5035
Loa Loa (eye worm)	hypothetical protein	0.0355	0.176	0.1609
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0355	0.176	0.5444
Trypanosoma brucei	Calpain-like protein 1.1	0.0115	0.0266	0.0823
Schistosoma mansoni	cathepsin C	0.0105	0.0204	0.0025
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0115	0.0266	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.0115	0.0266	0.0823
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0355	0.176	0.5444
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0355	0.176	0.1609
Trypanosoma cruzi	major cysteine proteinase, putative	0.0105	0.0204	0.0204
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.0204	0.0631
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0355	0.176	0.5444
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0355	0.176	0.5444
Giardia lamblia	Cathepsin B precursor	0.0591	0.3234	1
Schistosoma mansoni	calpain-7 (C02 family)	0.0401	0.2051	0.1906
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0115	0.0266	0.0823
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0355	0.176	0.5444
Schistosoma mansoni	microsomal glutathione s-transferase	0.0135	0.0391	0.0215
Trypanosoma brucei	calpain-like protein, putative	0.0401	0.2051	0.6343
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0286	0.1334	0.7578
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0401	0.2051	0.6343
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0105	0.0204	0.0025
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0355	0.176	0.176
Loa Loa (eye worm)	hypothetical protein	0.1676	1	1
Echinococcus granulosus	cathepsin L	0.0206	0.0835	0.0835
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0355	0.176	0.176
Schistosoma mansoni	calpain-2 (C02 family)	0.0115	0.0266	0.0088
Trypanosoma brucei	cysteine peptidase, putative	0.0115	0.0266	0.0823
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0206	0.0835	0.0667
Echinococcus granulosus	calpain A	0.1148	0.6703	0.6703
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0401	0.2051	0.2051
Onchocerca volvulus		0.0355	0.176	0.4373
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0355	0.176	1
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0401	0.2051	0.1906
Trypanosoma brucei	Calpain-like protein 2	0.0115	0.0266	0.0823
Trypanosoma cruzi	cysteine peptidase, putative	0.0355	0.176	0.176
Entamoeba histolytica	cysteine protease, putative	0.0206	0.0835	0.4743
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0355	0.176	0.5444
Entamoeba histolytica	cysteine protease, putative	0.0206	0.0835	0.4743
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0254	0.1129	0.3493
Trypanosoma brucei	calpain-like protein, putative	0.0401	0.2051	0.6343
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.1146	0.6695	0.6634
Entamoeba histolytica	cysteine protease, putative	0.0206	0.0835	0.4743
Echinococcus multilocularis	cathepsin b	0.1676	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0355	0.176	0.5444
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0115	0.0266	0.0823
Toxoplasma gondii	hypothetical protein	0.0115	0.0266	0.0205
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0105	0.0204	0.0631
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0105	0.0204	0.0129
Leishmania major	cysteine peptidase A (CPA)	0.0355	0.176	0.5035
Onchocerca volvulus		0.0355	0.176	0.4373
Brugia malayi	Papain family cysteine protease containing protein	0.0206	0.0835	0.0667
Echinococcus granulosus	cathepsin L	0.0105	0.0204	0.0204
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0591	0.3234	1
Entamoeba histolytica	cysteine protease, putative	0.0355	0.176	1
Brugia malayi	Cathepsin L-like precursor	0.0355	0.176	0.1609
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0355	0.176	0.5444
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.1077	0.6265	0.6197
Onchocerca volvulus	Cathepsin L homolog	0.0355	0.176	0.4373
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0355	0.176	0.5444
Schistosoma mansoni	calpain-7 (C02 family)	0.0401	0.2051	0.1906
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0115	0.0266	0.0823
Brugia malayi	fibroinase precursor	0.0105	0.0204	0.0025
Trypanosoma brucei	Calpain-like protein CALP1.3	0.0115	0.0266	0.0823
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0115	0.0266	0.0266
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0105	0.0204	0.0025
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0115	0.0266	0.0266
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0591	0.3234	1
Trypanosoma brucei	antigen, putative	0.0401	0.2051	0.6343
Echinococcus granulosus	calpain 7 C02 family	0.0401	0.2051	0.2051
Echinococcus multilocularis	calpain A	0.1148	0.6703	0.6703
Brugia malayi	cathepsin L-like cysteine proteinase	0.0105	0.0204	0.0025
Trichomonas vaginalis	calpain, putative	0.0115	0.0266	0.0823
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0206	0.0835	0.0667
Echinococcus granulosus	cathepsin b	0.1676	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0105	0.0204	0.0025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0206	0.0835	0.2582
Trypanosoma brucei	glucosamine 6-phosphate n-acetyltransferase	0.0115	0.0266	0.0823
Plasmodium falciparum	calpain	0.0115	0.0266	0.0399
Trichomonas vaginalis	conserved hypothetical protein	0.0105	0.0204	0.0631
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0591	0.3234	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0105	0.0204	0.0204
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.0204	0.0631
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0115	0.0266	0.0266
Echinococcus granulosus	cathepsin b	0.1676	1	1
Entamoeba histolytica	cysteine protease, putative	0.0206	0.0835	0.4743
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0204	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0962	0.5548	0.5467
Echinococcus granulosus	microsomal glutathione S transferase 3	0.0135	0.0391	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0676	0.3763	0.3649
Trypanosoma brucei	calpain-like protein, putative	0.0401	0.2051	0.6343
Brugia malayi	Cathepsin L-like precursor	0.0355	0.176	0.1609
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0204	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0204	0.0025
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0401	0.2051	0.2051
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0105	0.0204	0.0631
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.0204	0.0631
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0355	0.176	0.5444
Echinococcus multilocularis	cathepsin b	0.1676	1	1
Plasmodium vivax	vivapain-2	0.0355	0.176	0.8446
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0401	0.2051	0.2051
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0115	0.0266	0.0823
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0115	0.0266	0.0823
Plasmodium vivax	vivapain-2	0.0355	0.176	0.8446
Brugia malayi	calpain family protein 1	0.1077	0.6265	0.6197
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0105	0.0204	0.0025
Schistosoma mansoni	hypothetical protein	0.0115	0.0266	0.0088
Leishmania major	cathepsin L-like protease	0.0355	0.176	0.5035
Brugia malayi	Cathepsin L-like precursor	0.0355	0.176	0.1609
Brugia malayi	Cathepsin L-like precursor	0.0254	0.1129	0.0967
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0105	0.0204	0.0025
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0355	0.176	0.176
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0105	0.0204	0.0129
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.1146	0.6695	0.6695
Entamoeba histolytica	cysteine protease, putative	0.0206	0.0835	0.4743
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0254	0.1129	0.1129
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0115	0.0266	0.0823
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0105	0.0204	0.1159
Entamoeba histolytica	cysteine proteinase, putative	0.0206	0.0835	0.4743
Entamoeba histolytica	cysteine proteinase, putative	0.0355	0.176	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0355	0.176	0.5444
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0105	0.0204	0.0025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.0204	0.0631
Echinococcus granulosus	cathepsin L cysteine protease	0.0206	0.0835	0.0835
Giardia lamblia	Cathepsin B precursor	0.0591	0.3234	1
Entamoeba histolytica	hypothetical protein	0.0105	0.0204	0.1159
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0115	0.0266	0.0823
Trypanosoma cruzi	cysteine proteinase, putative	0.0206	0.0835	0.0835
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0206	0.0835	0.0667
Echinococcus multilocularis	cathepsin L	0.0206	0.0835	0.0835
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0115	0.0266	0.0823
Trypanosoma cruzi	conserved protein	0.0115	0.0266	0.0266
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0206	0.0835	0.0835
Brugia malayi	cathepsin L-like precursor	0.0254	0.1129	0.0967
Loa Loa (eye worm)	calpain 5	0.0286	0.1334	0.1175
Leishmania major	cathepsin L-like protease	0.0355	0.176	0.5035
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0115	0.0266	0.0823
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0206	0.0835	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0105	0.0204	0.0025
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0105	0.0204	0.0025
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0105	0.0204	0.0631
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0115	0.0266	0.0266
Brugia malayi	calpain D	0.0115	0.0266	0.0088
Brugia malayi	calpain 5	0.0286	0.1334	0.1175
Echinococcus granulosus	cathepsin l1	0.0355	0.176	0.176
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0115	0.0266	0.0266
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0115	0.0266	0.0266
Echinococcus multilocularis	cysteine protease	0.0355	0.176	0.176
Schistosoma mansoni	cathepsin F (C01 family)	0.0355	0.176	0.1609
Trypanosoma cruzi	cysteine peptidase, putative	0.0206	0.0835	0.0835
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1676	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 8.5 nM	Displacement of [125I]L-691,831 from 5-lipoxygenase-activating protein in human polymorphonuclear cells	ChEMBL.	22578458
IC50 (binding)	= 3700 nM	Inhibition of 5-lipoxygenase-activating protein in human polymorphonuclear cells assessed as inhibition of calcium ionophore-induced LTB4 production in presence of human whole blood	ChEMBL.	22578458

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2031451

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1657254