Detailed view for TcCLB.508555.50

Basic information

TDR Targets ID: 42587
Trypanosoma cruzi, calpain-like cysteine peptidase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.8296 | Length (AA): 715 | MW (Da): 80947 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00648   Calpain family cysteine protease
PF09149   Domain of unknown function (DUF1935)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0004198   calcium-dependent cysteine-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
38 146 1r75 (A) 12 132 24.00 0 0.88 0.53 -0.96
39 147 1r75 (A) 13 130 24.00 0 1 0.41 -0.82
151 715 1qxp (B) 2 602 23.00 0 1 0.64 0.94
172 518 1zcm (A) 40 353 29.00 0 1 0.78 -0.23
27 147 2fe0 (A) 1 126 30.00 0 1 0.472031 0.36
38 145 1r75 (A) 12 131 24.00 0 0.96 0.482849 -0.47
67 147 2fe0 (A) 46 124 42.00 0.000000033 0.97 0.515587 0.39
114 195 3qs7 (H) 166 253 32.00 0.29 0.1 0.123985 2.25
154 714 1kfu (L) 5 574 21.00 0 1 0.801415 1.22
175 516 3bow (A) 33 341 30.00 0 1 0.743622 0.09
181 516 2nqa (A) 39 341 32.00 0 0.91 0.61423 0.81

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_142825)

Species Accession Gene Product
Leishmania braziliensis LbrM.31.0620   calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative
Leishmania donovani LdBPK_310480.1   calpain-like cysteine peptidase, putative
Leishmania infantum LinJ.31.0480   calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative
Leishmania major LmjF.31.0460   calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative
Leishmania mexicana LmxM.30.0460f  
Leishmania mexicana LmxM.30.0460d  
Leishmania mexicana LmxM.30.0460e  
Leishmania mexicana LmxM.30.0460a  
Leishmania mexicana LmxM.30.0460b  
Trypanosoma cruzi TcCLB.509237.120   cysteine peptidase, Clan CA, family C2, putative
Trypanosoma cruzi TcCLB.508555.50   calpain-like cysteine peptidase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 687 aa 32.0% 684 aa Compounds References
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 414 aa 25.7% 416 aa Compounds References
Leishmania major calpain family cysteine protease-like protein 705 aa 35.2% 687 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0629 0.499 0.7151
0.1371 0.7147 0.7143
0.0714 0.716 0.716
0.0253 0.3008 0.7105
0.0634 0.6951 0.7118
0.0651 0.7099 0.709
0.0692044 0.502518 0.706526
0.0655 0.716 0.716
0.0591 0.3405 0.7047
0.0361 0.3492 0.3492
0.0552 0.6001 0.704
0.0629 0.499 0.7151
0.0679 0.3135 0.5641
0.0458 0.7099 0.7047
0.0613 0.7154 0.7154
0.0631 0.7154 0.7154
0.0651 0.2958 0.2958
0.0551 0.6553 0.7013
0.0615 0.6448 0.7197
0.0722 0.4404 0.7125
0.0644 0.6437 0.7133
0.0542 0.4433 0.7045
0.0468 0.7216 0.7214
0.0361 0.3492 0.3492
0.0667 0.7154 0.7154
0.0498 0.6847 0.6838
0.0587 0.718 0.7179
0.062 0.7154 0.7154
0.0566 0.5291 0.7116
0.0653 0.2611 0.3948
0.0526 0.2849 0.7473
0.0644 0.253 0.7171
0.13 0.5249 0.7205
0.0695 0.7179 0.7179
0.1116 0.5276 0.7228
0.0588 0.5894 0.7126
0.0618 0.4057 0.7125
0.0708 0.718 0.7179
0.0614 0.7197 0.719
0.0611 0.4128 0.7131
0.0714 0.4378 0.7143
0.0607 0.7182 0.7182
0.0544 0.5468 0.5453
0.0588 0.5894 0.7126
0.0721 0.3294 0.7113
0.0667 0.7167 0.7167
0.0643 0.716 0.716
0.0615 0.2871 0.7119
0.062 0.724 0.7238
0.0659 0.2676 0.2663
0.0553 0.5421 0.712
0.0601 0.2528 0.7086
0.0657 0.3306 0.329
0.062 0.716 0.716
0.049 0.3806 0.6856
0.0598 0.714 0.7086
0.0702 0.718 0.7179
0.1371 0.5249 0.7205
0.0584 0.7162 0.716
0.1167 0.5249 0.7205
0.0627 0.4381 0.4475
0.0683 0.7301 0.7301
0.0638 0.4929 0.7182
0.0583 0.6531 0.7148
0.061 0.6491 0.7131
0.0553 0.4475 0.4889
0.0687 0.4302 0.7171
0.071 0.7233 0.7213
0.0492 0.3402 0.7154
0.0676 0.285 0.7182
0.0553 0.5412 0.6906
0.1371 0.5249 0.7205
0.068 0.3936 0.396
0.0715 0.718 0.7179
0.1453 0.7147 0.7143
0.1443 0.7143 0.7143
0.0693 0.716 0.716
0.0694 0.7107 0.71
0.0533 0.5778 0.5776
0.0702 0.3006 0.3517
0.0566 0.5291 0.7116
0.0644 0.7181 0.7171
0.0721 0.7132 0.7131
0.0575 0.5345 0.711
0.0463 0.7155 0.7155
0.0361 0.3492 0.3492
0.0654 0.7143 0.7143
0.0601 0.3899 0.651
0.1443 0.7147 0.7143
0.0591 0.3405 0.7047
0.0655 0.7197 0.719
0.1116 0.5276 0.7228
0.0687 0.5392 0.7182
0.0709 0.7199 0.7197
0.0553 0.4475 0.4889
0.138894 0.709746 0.706941
0.1443 0.7154 0.7147
0.0315 0.3056 0.7089
0.0715 0.316 0.3149
0.0583 0.309 0.7113
0.0625 0.7181 0.7171
0.0579 0.716 0.716
0.0562 0.623 0.7036
0.0629 0.499 0.7151
0.0582 0.3819 0.7047
0.068 0.716 0.716
0.0683 0.7301 0.7301
0.1371 0.7147 0.7143
0.0578 0.6643 0.7197
0.0664 0.3486 0.7171
0.0591 0.7193 0.719
0.0615 0.4331 0.721
0.062 0.3509 0.7087
0.0614 0.5338 0.7232
0.0673 0.4794 0.6216
0.0544 0.5633 0.7061
0.0707 0.7154 0.7154
0.0613 0.3231 0.3224
0.0627 0.679 0.7129
0.0657 0.3281 0.3269
0.06 0.7197 0.719
0.0709 0.7199 0.7197
0.0618 0.4057 0.7125
0.0552 0.6001 0.704
0.064 0.6533 0.7154
0.0613 0.3252 0.3245
0.0553 0.4475 0.4889
0.0605 0.4996 0.7065
0.0643 0.2569 0.2561
0.068 0.3936 0.396
0.053 0.4263 0.6986
0.0614 0.5338 0.7232
0.0664 0.3486 0.7171
0.1453 0.7147 0.7143
0.0636 0.7115 0.7131
0.0735 0.7251 0.725
0.13 0.5249 0.7205
0.0463 0.7147 0.7143
0.0638 0.7162 0.7137
0.039 0.4446 0.7137
0.13 0.5249 0.7205
0.1044 0.5254 0.7211
0.1371 0.7147 0.7143
0.0707 0.7154 0.7154
0.0615 0.2871 0.7119
0.0655 0.7154 0.7154
0.0613 0.7154 0.7154
0.0562 0.623 0.7036
0.1238 0.7147 0.7143
0.0552 0.3425 0.5331
0.0618 0.3143 0.3131
0.1443 0.7154 0.7147
0.0598 0.3859 0.6508
0.058 0.7191 0.7179
0.0361 0.3492 0.3492
0.0706 0.4182 0.7114
0.0698 0.5345 0.7171
0.0584 0.7162 0.716
0.0707 0.716 0.716
0.0788 0.596 0.7193
0.0643 0.716 0.716
0.131 0.7147 0.7143
0.0665 0.7193 0.7182
0.0649 0.7131 0.7131
0.0665 0.2579 0.7171
0.1044 0.5194 0.7162
0.1238 0.7147 0.7143
0.0677 0.2771 0.277
0.0599 0.716 0.716
0.0576 0.3721 0.465
0.06 0.716 0.716
0.0635 0.7173 0.7171
0.0579 0.3174 0.3166
0.0735 0.7251 0.725
0.0599 0.5677 0.7047
0.1371 0.5237 0.7198
0.1453 0.7147 0.7143
0.0615 0.6448 0.7197
0.0653 0.2611 0.3948
0.062 0.724 0.7238
0.0559 0.4199 0.7037
0.07 0.7154 0.7154
0.0721 0.7178 0.7154
0.0615 0.6322 0.7126
0.0612 0.7216 0.7216
0.0651 0.7092 0.7134
0.0326 0.7143 0.7143
0.0664 0.3486 0.7171
0.131 0.7147 0.7143
0.1381 0.7147 0.7143
0.0679 0.3135 0.5641
0.0735 0.7251 0.725
0.0283 0.2828 0.7211
0.1381 0.7147 0.7143
0.0653 0.2611 0.3948
0.0602 0.4288 0.5529
0.0644 0.3951 0.7209
0.0509 0.5611 0.5592
0.0720765 0.69854 0.69854
0.0677 0.7035 0.7179
0.0615 0.3462 0.7104
0.0583 0.309 0.7113
0.118301 0.709794 0.706941
0.1381 0.7147 0.7143
0.0553 0.4475 0.4889
0.0662 0.6697 0.7266
0.1299 0.7147 0.7143
0.0718 0.286 0.3011
0.0463 0.7155 0.7155
0.039 0.4594 0.7089
0.061 0.6838 0.6838
0.0361 0.3492 0.3492
0.0668 0.7197 0.719
0.0665 0.2579 0.7171
0.0587 0.718 0.7179
0.0669 0.2851 0.2839
0.1371 0.7147 0.7143
0.0361 0.3492 0.3492
0.131 0.7147 0.7143
0.0558 0.6206 0.704
0.0702 0.3006 0.3517
0.118301 0.709794 0.706941
0.0637 0.6363 0.7132
0.0591 0.4299 0.6815
0.0702 0.7197 0.719
0.0686 0.3607 0.7222
0.1443 0.7147 0.7143
0.0615 0.4331 0.721
0.0628 0.6281 0.719
0.1044 0.7147 0.7143
0.0629 0.7197 0.719
0.1371 0.5237 0.7198
0.062 0.7173 0.7171
0.0583 0.6531 0.7148
0.0543 0.6174 0.7042
0.0604 0.7162 0.716
0.0677 0.6918 0.7179
0.061 0.7197 0.719
0.0655 0.7135 0.7179
0.0702 0.3006 0.3517
0.0361 0.3492 0.3492
0.0606 0.3904 0.6518
0.0361 0.3492 0.3492
0.0649 0.3278 0.6032
0.0681 0.7267 0.7267
0.049 0.3806 0.6856
0.0709 0.7199 0.7197
0.0632 0.3505 0.3805
0.0573 0.5638 0.624
0.1371 0.5237 0.7198
0.0587 0.7193 0.719
0.0677 0.7035 0.7179
0.0683 0.7301 0.7301
0.0582 0.3819 0.7047
0.0684 0.7181 0.7171
0.0645 0.7131 0.7131
0.0603 0.7194 0.7193
0.0629 0.499 0.7151
0.061 0.6838 0.6838
0.1458 0.7154 0.7147
0.0615 0.7154 0.7154
0.0687 0.5392 0.7182
0.0615 0.6448 0.7197
0.062 0.716 0.716
0.0644 0.3905 0.7171
0.0583 0.6531 0.7148
0.0599 0.716 0.716
0.0651 0.4405 0.7171
0.0589 0.716 0.716
0.061 0.6838 0.6838
0.0582 0.413 0.7167
0.0655 0.7154 0.7154
0.0604 0.7154 0.7154
0.0598 0.7103 0.7087
0.0553 0.5412 0.6906
0.0721 0.7091 0.7063
0.0702 0.3006 0.3517
0.0623 0.7193 0.719
0.0615 0.4331 0.721
0.0715 0.718 0.7179
0.0321 0.7047 0.7047
0.0559 0.5398 0.7092
0.0582 0.413 0.7167
0.0735 0.7162 0.7162
0.0601 0.3043 0.3025
0.0591 0.7193 0.719
0.0553 0.5401 0.5915
0.0616 0.481 0.7171
0.0566 0.5291 0.7116
0.0694 0.7107 0.71
0.0584 0.7094 0.7047
0.0578 0.716 0.716
0.0454 0.3375 0.7518
0.1371 0.5237 0.7198
0.0321 0.7091 0.706
0.0721 0.3294 0.7113
0.0702 0.718 0.7179
0.0594 0.6307 0.718
0.0634 0.2888 0.2877
0.0553 0.4475 0.4889
0.0687 0.2636 0.7087
0.0678 0.7087 0.7194
0.0612 0.7173 0.7171
0.061 0.6491 0.7131
0.0599 0.716 0.716
0.064 0.6533 0.7154
0.0707 0.7154 0.7154
0.0696 0.718 0.7179
0.0631 0.3133 0.3127
0.0599 0.716 0.716
0.1044 0.5254 0.7211
0.0619 0.719 0.719
0.0544 0.5468 0.5453
0.0644 0.3905 0.7171
0.0598 0.7171 0.7171
0.0585 0.7131 0.7131
0.0592 0.4368 0.4876
0.0584 0.716 0.716
0.0615 0.4331 0.721
0.0544 0.5633 0.7061
0.1299 0.7147 0.7143
0.0673 0.4794 0.6216
0.061 0.6838 0.6838
0.0635 0.7182 0.7182

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.508555.50 (Trypanosoma cruzi), calpain-like cysteine peptidase, putative
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