Detailed information for compound 1429521

Basic information

Technical information
  • TDR Targets ID: 1429521
  • Name: 6-methyl-2-morpholin-4-yl-2-(trifluoromethyl) -4H-1,4-benzoxazin-3-one
  • MW: 316.276 | Formula: C14H15F3N2O3
  • H donors: 1 H acceptors: 1 LogP: 1.97 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)NC(=O)C(O2)(N1CCOCC1)C(F)(F)F
  • InChi: 1S/C14H15F3N2O3/c1-9-2-3-11-10(8-9)18-12(20)13(22-11,14(15,16)17)19-4-6-21-7-5-19/h2-3,8H,4-7H2,1H3,(H,18,20)
  • InChiKey: NTUPXCFLOOSZKT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-methyl-2-morpholino-2-(trifluoromethyl)-4H-1,4-benzoxazin-3-one
  • 6-methyl-2-morpholin-4-yl-2-(trifluoromethyl)-2H-1,4-benzoxazin-3(4H)-one
  • MLS000085879
  • SMR000021208
  • A2939/0123739
  • 4H-Benzo[1,4]oxazin-3-one, 6-methyl-2-morpholin-4-yl-2-trifluoromethyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0264 0.2519 0.3152
Trypanosoma cruzi calmodulin, putative 0.0045 0.0309 0.0321
Giardia lamblia Cathepsin B precursor 0.0107 0.093 0.2665
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0021 0.0042
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0336 0.0699
Brugia malayi beta-lactamase family protein 0.0036 0.0221 0.0232
Entamoeba histolytica cysteine proteinase, putative 0.0469 0.4583 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0252 0.2399 0.3
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.2411 0.509
Leishmania major cathepsin L-like protease 0.0469 0.4583 0.5755
Leishmania major hypothetical protein, conserved 0.0338 0.3261 0.4088
Leishmania major protein kinase, putative 0.0045 0.0309 0.0364
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0355 0.3433 0.3437
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0045 0.0309 0.0309
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0107 0.093 0.1941
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.05 0.0524
Trypanosoma cruzi caltractin, putative 0.0045 0.0309 0.0321
Trichomonas vaginalis calmodulin, putative 0.0045 0.0309 0.0615
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0107 0.093 0.1937
Brugia malayi Cathepsin L-like precursor 0.0147 0.1334 0.1399
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0107 0.093 0.1937
Trichomonas vaginalis calmodulin, putative 0.0045 0.0309 0.0615
Echinococcus multilocularis cysteine protease 0.0469 0.4583 0.4583
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0252 0.2399 0.3
Trypanosoma brucei centrin, putative 0.0045 0.0309 0.0364
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0794 0.0794
Echinococcus multilocularis cathepsin L 0.0107 0.093 0.093
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.005 0.0038
Onchocerca volvulus 0.0027 0.0129 0.0273
Echinococcus multilocularis calmodulin 0.0045 0.0309 0.0309
Plasmodium vivax unspecified product 0.0147 0.1334 0.278
Trichomonas vaginalis set domain proteins, putative 0.0482 0.4717 1
Mycobacterium ulcerans beta-lactamase 0.0036 0.0221 1
Loa Loa (eye worm) hypothetical protein 0.0722 0.7136 0.7485
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0221 0.0918
Brugia malayi PAN domain containing protein 0.0028 0.0135 0.0141
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0794 0.0794
Leishmania major centrin, putative 0.0045 0.0309 0.0364
Trypanosoma cruzi centrin, putative 0.0053 0.0392 0.0412
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0221 0.0427
Loa Loa (eye worm) hypothetical protein 0.0023 0.0083 0.0087
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0754 0.7463 0.9389
Schistosoma mansoni cathepsin F (C01 family) 0.0469 0.4583 0.4587
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0444 0.0444
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.005 0.0038
Trypanosoma brucei hypothetical protein, conserved 0.0045 0.0309 0.0364
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0025 0.0025
Trichomonas vaginalis calcium binding protein, putative 0.0045 0.0309 0.0615
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0045 0.0053
Loa Loa (eye worm) PAN domain-containing protein 0.0028 0.0135 0.0141
Brugia malayi calpain 5 0.0238 0.2251 0.2361
Giardia lamblia Cathepsin L-like protease 0.0107 0.093 0.2665
Entamoeba histolytica cysteine protease, putative 0.0253 0.2411 0.5208
Entamoeba histolytica cysteine proteinase 2 0.0253 0.2411 0.5208
Loa Loa (eye worm) RecQ helicase 0.0022 0.0071 0.0075
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0758 0.7508 0.9445
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.005 0.0033
Echinococcus multilocularis calpain 5 0.049 0.4797 0.4797
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0107 0.093 0.1994
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0107 0.093 0.1937
Brugia malayi cathepsin L-like cysteine proteinase 0.0107 0.093 0.0976
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.4583 0.9715
Loa Loa (eye worm) EF hand family protein 0.0045 0.0309 0.0324
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.2259 0.2259
Entamoeba histolytica cysteine proteinase, putative 0.0322 0.3102 0.6733
Plasmodium vivax SET domain protein, putative 0.0061 0.0466 0.0971
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0469 0.4583 0.9715
Echinococcus granulosus EF hand domain containing family member A2 0.0046 0.0319 0.0319
Plasmodium vivax vivapain-2 0.0469 0.4583 0.9554
Echinococcus multilocularis calbindin 32 0.0046 0.0319 0.0319
Plasmodium falciparum serine repeat antigen 3 0.0107 0.093 0.1994
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0045 0.0309 0.0643
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.005 0.0053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0794 0.0794
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.068 0.6719 0.744
Schistosoma mansoni mitochondrial solute carrier 0.0045 0.0309 0.0309
Brugia malayi Cathepsin L-like precursor 0.0469 0.4583 0.4807
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-4 0.0208 0.1957 0.2442
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0461 0.4502 0.4978
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0794 0.0795
Brugia malayi calpain family protein 1 0.0959 0.9534 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0221 0.0427
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0423 0.4126 0.4328
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0107 0.093 0.0931
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0001 0.0001
Toxoplasma gondii thioredoxin reductase 0.0048 0.0336 0.0692
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0221 0.0427
Plasmodium falciparum thioredoxin reductase 0.0048 0.0336 0.0692
Brugia malayi Thioredoxin reductase 0.0048 0.0336 0.0352
Toxoplasma gondii calmodulin CAM1 0.0046 0.0319 0.0654
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0699 0.6907 0.8688
Brugia malayi Cathepsin L-like precursor 0.0322 0.3102 0.3254
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0071 0.0075
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0802 0.7948 1
Plasmodium falciparum cysteine repeat modular protein 1 0.006 0.0463 0.0971
Loa Loa (eye worm) hypothetical protein 0.0028 0.0135 0.0141
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.1077 1
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0252 0.2399 0.5064
Echinococcus multilocularis calcium uptake protein 1 0.0046 0.0319 0.0319
Trypanosoma cruzi kinesin, putative 0.0238 0.2251 0.2478
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0252 0.2399 0.5212
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0443 0.4321 0.5425
Onchocerca volvulus Cathepsin L homolog 0.0107 0.093 0.1971
Entamoeba histolytica cysteine protease, putative 0.0253 0.2411 0.5208
Onchocerca volvulus 0.0028 0.0135 0.0286
Echinococcus multilocularis dna polymerase eta 0.0045 0.031 0.031
Brugia malayi intermediate filament protein 0.0027 0.0129 0.0135
Brugia malayi PAN domain containing protein 0.0028 0.0135 0.0141
Trypanosoma brucei cysteine peptidase, putative 0.0461 0.4502 0.5653
Giardia lamblia Cathepsin B precursor 0.0107 0.093 0.2665
Trypanosoma cruzi hypothetical protein, conserved 0.0338 0.3261 0.36
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0208 0.1957 0.2151
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0253 0.2411 0.2413
Loa Loa (eye worm) hypothetical protein 0.0027 0.0124 0.013
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0045 0.0309 0.0615
Leishmania major cathepsin L-like protease 0.0469 0.4583 0.5755
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0305 0.2927 0.3667
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0802 0.7948 0.8805
Plasmodium falciparum serine repeat antigen 2 0.0107 0.093 0.1994
Echinococcus multilocularis programmed cell death protein 0.0053 0.0392 0.0392
Loa Loa (eye worm) PAN domain-containing protein 0.0028 0.0135 0.0141
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0758 0.7508 0.9445
Echinococcus multilocularis calpain family protein 1, d 0.0722 0.7136 0.7136
Mycobacterium ulcerans DNA polymerase IV 0.002 0.005 0.1485
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.000000034185 0.000000034185
Loa Loa (eye worm) cathepsin B 0.0355 0.3433 0.3601
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0794 0.0794
Brugia malayi TAR-binding protein 0.0064 0.05 0.0524
Loa Loa (eye worm) matrix metalloproteinase 0.0023 0.0083 0.0087
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.2202 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0107 0.093 0.1937
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0021 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0955 0.4282
Trypanosoma brucei small myristoylated protein 1-2 0.036 0.3482 0.4366
Trichomonas vaginalis esterase, putative 0.0036 0.0221 0.0427
Onchocerca volvulus 0.0107 0.093 0.1971
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0071 0.0071
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.005 0.005
Echinococcus multilocularis tar DNA binding protein 0.0064 0.05 0.05
Toxoplasma gondii ABC1 family protein 0.0036 0.0221 0.0439
Brugia malayi Papain family cysteine protease containing protein 0.0107 0.093 0.0976
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0045 0.0309 0.0364
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0469 0.4583 0.9715
Loa Loa (eye worm) hypothetical protein 0.0469 0.4583 0.4807
Echinococcus multilocularis programmed cell death protein 0.0053 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0028 0.0135 0.0141
Loa Loa (eye worm) hypothetical protein 0.0028 0.0135 0.0141
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0129 0.0135
Schistosoma mansoni calmodulin 0.0045 0.0309 0.0309
Trypanosoma brucei calpain-like protein, putative 0.049 0.4797 0.6025
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.000000034185 0.000000034218
Leishmania major calmodulin-like protein 0.0045 0.0309 0.0364
Giardia lamblia Cathepsin B precursor 0.0355 0.3433 1
Echinococcus multilocularis cysteine protease 0.0469 0.4583 0.4583
Brugia malayi EF hand family protein 0.0046 0.0319 0.0334
Toxoplasma gondii PAN/Apple domain-containing protein 0.0028 0.0135 0.025
Entamoeba histolytica cysteine protease, putative 0.0253 0.2411 0.5208
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0754 0.7463 0.8267
Toxoplasma gondii PAN domain-containing protein 0.0028 0.0135 0.025
Echinococcus granulosus calmodulin 0.0045 0.0309 0.0309
Brugia malayi calpain 5 0.0252 0.2399 0.2516
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0461 0.4502 0.4978
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0754 0.7463 0.8267
Leishmania major calpain family cysteine protease-like protein 0.0461 0.4502 0.5653
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.4583 0.9715
Echinococcus granulosus calumenin 0.0046 0.0319 0.0319
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0461 0.4502 0.4978
Mycobacterium tuberculosis Conserved protein 0.0036 0.0221 0.0918
Echinococcus multilocularis lamin dm0 0.0027 0.0129 0.0129
Entamoeba histolytica hypothetical protein 0.0107 0.093 0.1941
Leishmania major calmodulin-like protein 0.0045 0.0309 0.0364
Trypanosoma brucei Calpain-like protein 1.1 0.0802 0.7948 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0107 0.093 0.1937
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0046 0.0319 0.0319
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0111 0.0229
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0305 0.2927 0.3229
Toxoplasma gondii microneme protein MIC17B 0.0028 0.0135 0.025
Leishmania major small myristoylated protein-1 0.036 0.3482 0.4366
Echinococcus multilocularis cathepsin L 0.0253 0.2411 0.2411
Trichomonas vaginalis calcium binding proteins, putative 0.0045 0.0309 0.0615
Echinococcus multilocularis geminin 0.0171 0.1583 0.1583
Entamoeba histolytica calmodulin, putative 0.0045 0.0309 0.0571
Brugia malayi calpain family protein 1 0.0959 0.9534 1
Trypanosoma brucei centrin-3 0.0053 0.0392 0.0468
Onchocerca volvulus 0.0028 0.0135 0.0286
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0469 0.4583 0.9715
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0469 0.4583 1
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0208 0.1957 0.2151
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0208 0.1957 0.2442
Echinococcus granulosus calpain A 0.049 0.4797 0.4797
Schistosoma mansoni centrin 0.0045 0.0309 0.0309
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0336 0.0336
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0955 0.4282
Trichomonas vaginalis centrin, putative 0.0045 0.0309 0.0615
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0208 0.1957 0.2442
Loa Loa (eye worm) beta-lactamase 0.0036 0.0221 0.0232
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0567 0.5572 0.6167
Schistosoma mansoni hypothetical protein 0.0032 0.0178 0.0179
Trypanosoma brucei calmodulin, putative 0.0046 0.0319 0.0376
Trypanosoma brucei calmodulin, putative 0.0045 0.0309 0.0364
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.2259 0.2259
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0443 0.4321 0.5425
Giardia lamblia Hypothetical protein 0.0107 0.093 0.2665
Brugia malayi cathepsin L-like precursor 0.0322 0.3102 0.3254
Trichomonas vaginalis calcineurin B subunit, putative 0.0045 0.0309 0.0615
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0221 0.0918
Schistosoma mansoni survival motor neuron protein 0.0049 0.0344 0.0344
Leishmania major cathepsin L-like protease 0.0562 0.5528 0.6947
Trichomonas vaginalis calcium binding protein, putative 0.0053 0.0392 0.079
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0107 0.093 0.2665
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0754 0.7463 0.9389
Trypanosoma cruzi hypothetical protein, conserved 0.0338 0.3261 0.36
Brugia malayi PAN domain containing protein 0.0028 0.0135 0.0141
Giardia lamblia Cathepsin L precursor 0.0107 0.093 0.2665
Schistosoma mansoni cathepsin B (C01 family) 0.0107 0.093 0.0931
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0463 0.0492
Onchocerca volvulus 0.0028 0.0135 0.0286
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0336 0.0352
Trypanosoma cruzi cysteine peptidase, putative 0.0147 0.1334 0.1459
Onchocerca volvulus 0.006 0.0463 0.0982
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.1139 0.1139
Trichomonas vaginalis calmodulin, putative 0.0045 0.0309 0.0615
Echinococcus multilocularis musashi 0.0027 0.0129 0.0129
Leishmania major cathepsin L-like protease 0.0469 0.4583 0.5755
Leishmania major hypothetical protein, conserved 0.0208 0.1957 0.2442
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0469 0.4583 0.9715
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.049 0.4797 0.5305
Giardia lamblia Cathepsin L precursor 0.0107 0.093 0.2665
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0469 0.4583 0.9715
Trypanosoma brucei mitochondrial calcium uptake 1 0.0045 0.0309 0.0364
Brugia malayi hypothetical protein 0.0016 0.0019 0.002
Mycobacterium leprae Probable lipase LipE 0.0036 0.0221 0.0934
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0221 0.0221
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0221 0.0918
Toxoplasma gondii PAN domain-containing protein 0.0028 0.0135 0.025
Loa Loa (eye worm) calpain 5 0.0238 0.2251 0.2361
Brugia malayi PAN domain containing protein 0.0028 0.0135 0.0141
Brugia malayi cathepsin B-like cysteine proteinase 0.0909 0.9023 0.9464
Trypanosoma brucei Calpain-like protein 2 0.0588 0.5783 0.727
Plasmodium falciparum glutathione reductase 0.0048 0.0336 0.0692
Plasmodium vivax unspecified product 0.0253 0.2411 0.5026
Plasmodium vivax unspecified product 0.0107 0.093 0.1938
Echinococcus granulosus calbindin 32 0.0046 0.0319 0.0319
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0469 0.4583 0.4807
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0469 0.4583 0.4807
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0461 0.4502 0.5653
Schistosoma mansoni neuronal calcium sensor 0.0045 0.0309 0.0309
Loa Loa (eye worm) TK/ROR protein kinase 0.006 0.0463 0.0486
Schistosoma mansoni tar DNA-binding protein 0.0064 0.05 0.05
Onchocerca volvulus 0.0028 0.0135 0.0286
Entamoeba histolytica cysteine protease, putative 0.0107 0.093 0.1941
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0309 0.0615
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0802 0.7948 1
Brugia malayi Cathepsin L-like precursor 0.0469 0.4583 0.4807
Trypanosoma brucei unspecified product 0.002 0.005 0.0038
Brugia malayi beta-lactamase family protein 0.0036 0.0221 0.0232
Trypanosoma brucei trypanothione reductase 0.0048 0.0336 0.0398
Loa Loa (eye worm) hypothetical protein 0.0028 0.0135 0.0141
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0045 0.0309 0.0309
Plasmodium vivax glutathione reductase, putative 0.0048 0.0336 0.0699
Giardia lamblia Cathepsin L precursor 0.0107 0.093 0.2665
Brugia malayi Cathepsin L-like precursor 0.0322 0.3102 0.3254
Echinococcus granulosus tar DNA binding protein 0.0064 0.05 0.05
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0794 0.0833
Schistosoma mansoni calpain-7 (C02 family) 0.049 0.4797 0.4802
Loa Loa (eye worm) hypothetical protein 0.0238 0.2259 0.2369
Brugia malayi hypothetical protein 0.0238 0.2259 0.2369
Plasmodium vivax vivapain-2 0.0469 0.4583 0.9554
Leishmania major small myristoylated protein-3, putative 0.0305 0.2927 0.3667
Mycobacterium ulcerans lipase LipD 0.0036 0.0221 1
Loa Loa (eye worm) hypothetical protein 0.0909 0.9023 0.9464
Loa Loa (eye worm) hypothetical protein 0.0027 0.0129 0.0135
Loa Loa (eye worm) hypothetical protein 0.0707 0.6989 0.733
Entamoeba histolytica cysteine protease, putative 0.0253 0.2411 0.5208
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0045 0.0309 0.0615
Trypanosoma cruzi kinesin, putative 0.0238 0.2251 0.2478
Echinococcus multilocularis thyroid hormone receptor alpha 0.0138 0.1242 0.1242
Brugia malayi MH2 domain containing protein 0.0125 0.1112 0.1166
Echinococcus multilocularis calpain 0.049 0.4797 0.4797
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.2411 0.5208
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0322 0.3102 0.6562
Brugia malayi Cathepsin L-like precursor 0.0469 0.4583 0.4807
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0461 0.4502 0.4978
Schistosoma mansoni tar DNA-binding protein 0.0064 0.05 0.05
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0336 0.035
Plasmodium vivax serine-repeat antigen (SERA) 0.0107 0.093 0.1938
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0466 0.0467
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0107 0.093 0.1938
Brugia malayi glutathione reductase 0.0048 0.0336 0.0352
Trypanosoma brucei protein I/6 0.0045 0.0309 0.0364
Trichomonas vaginalis calcineurin B subunit, putative 0.0046 0.0319 0.0635
Onchocerca volvulus 0.0469 0.4583 0.9714
Brugia malayi Protein kinase domain containing protein 0.006 0.0463 0.0486
Echinococcus multilocularis EF hand domain containing family member A2 0.0045 0.0309 0.0309
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0573 0.5638 0.624
Trypanosoma cruzi cruzipain precursor, putative 0.0147 0.1334 0.1459
Trypanosoma cruzi cysteine proteinase, putative 0.0253 0.2411 0.2655
Trypanosoma brucei antigen, putative 0.049 0.4797 0.6025
Trypanosoma cruzi cysteine peptidase, putative 0.0562 0.5528 0.6117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0562 0.5528 0.6947
Trypanosoma brucei I/6 autoantigen 0.0045 0.0309 0.0364
Loa Loa (eye worm) calmodulin-like protein 0.0045 0.0309 0.0324
Leishmania major DNA polymerase eta, putative 0.0032 0.0174 0.0194
Trypanosoma cruzi conserved protein 0.047 0.4592 0.5078
Trypanosoma cruzi centrin-3 0.0053 0.0392 0.0412
Loa Loa (eye worm) hypothetical protein 0.0147 0.1334 0.1399
Entamoeba histolytica cysteine protease, putative 0.0107 0.093 0.1941
Leishmania major cathepsin L-like protease 0.0562 0.5528 0.6947
Trypanosoma brucei calpain, putative 0.0516 0.5065 0.6363
Plasmodium falciparum serine repeat antigen 5 0.0107 0.093 0.1994
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0754 0.7463 0.8267
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0355 0.3433 0.4305
Toxoplasma gondii cathepsin B 0.0355 0.3433 0.748
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0322 0.3102 0.6562
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0221 0.0459
Trypanosoma brucei Calpain-like protein 1.2 0.0606 0.5964 0.7498
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0264 0.2519 0.2776
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0469 0.4583 0.4583
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0107 0.093 0.0931
Echinococcus granulosus lamin 0.0027 0.0129 0.0129
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0461 0.4502 0.5653
Trichomonas vaginalis calmodulin, putative 0.0045 0.0309 0.0615
Trypanosoma cruzi major cysteine proteinase, putative 0.0107 0.093 0.101
Leishmania major hypothetical protein, conserved 0.0208 0.1957 0.2442
Onchocerca volvulus 0.0028 0.0135 0.0286
Schistosoma mansoni hypothetical protein 0.0171 0.1583 0.1585
Onchocerca volvulus 0.0036 0.0221 0.0468
Entamoeba histolytica cysteine protease, putative 0.0253 0.2411 0.5208
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.000000034185 0.000000034185
Brugia malayi RNA binding protein 0.0064 0.05 0.0524
Loa Loa (eye worm) fibroinase 0.0469 0.4583 0.4807
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0252 0.2399 0.5064
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.049 0.4797 0.5305
Trypanosoma cruzi cysteine peptidase, putative 0.0253 0.2411 0.2655
Trypanosoma cruzi calmodulin, putative 0.0045 0.0309 0.0321
Leishmania major programmed cell death 6 protein-like protein 0.0045 0.0309 0.0364
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0355 0.3433 0.7267
Loa Loa (eye worm) calpain family protein 1 0.0959 0.9534 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0469 0.4583 0.4583
Loa Loa (eye worm) hypothetical protein 0.0028 0.0133 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.005 0.0038
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0606 0.5964 0.6602
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.031 0.0322
Brugia malayi EF hand family protein 0.0045 0.0309 0.0324
Leishmania major calpain protease-like protein 0.0252 0.2399 0.3
Trypanosoma cruzi cysteine peptidase, putative 0.0469 0.4583 0.5068
Onchocerca volvulus 0.0322 0.3102 0.6575
Schistosoma mansoni cathepsin F (C01 family) 0.0469 0.4583 0.4587
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0083 0.0687 0.0687
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0562 0.5528 0.6947
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0107 0.093 0.0931
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.1077 0.4845
Leishmania major cathepsin L-like protease 0.0562 0.5528 0.6947
Entamoeba histolytica cysteine protease, putative 0.0253 0.2411 0.5208
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0264 0.2519 0.3152
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0305 0.2927 0.3229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.4583 0.9715
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.049 0.4797 0.6025
Loa Loa (eye worm) cysteine protease 0.0469 0.4583 0.4807
Schistosoma mansoni cathepsin s 0.0147 0.1334 0.1335
Trypanosoma brucei hypothetical protein 0.0516 0.5065 0.6363
Leishmania major calcineurin B subunit, putative 0.0045 0.0309 0.0364
Brugia malayi beta-lactamase 0.0036 0.0221 0.0232
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.2411 0.5208
Echinococcus granulosus centrin 2 0.0045 0.0309 0.0309
Onchocerca volvulus 0.0028 0.0135 0.0286
Entamoeba histolytica cysteine protease, putative 0.0253 0.2411 0.5208
Trypanosoma cruzi calmodulin, putative 0.0045 0.0309 0.0321
Brugia malayi Papain family cysteine protease containing protein 0.0107 0.093 0.0976
Onchocerca volvulus 0.0036 0.0221 0.0468
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.005 0.0038
Toxoplasma gondii microneme protein, putative 0.0028 0.0135 0.025
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0606 0.5964 0.7498
Loa Loa (eye worm) hypothetical protein 0.0061 0.0466 0.0489
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0264 0.2519 0.3152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.4583 0.9715
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0045 0.0309 0.0321
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.031 0.0326
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0221 0.0253
Leishmania major centrin, putative 0.0045 0.0309 0.0364
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0221 0.0427
Giardia lamblia Cysteine protease 0.0107 0.093 0.2665
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0021 0.0021
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0802 0.7948 0.8805
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0466 0.0977
Trypanosoma brucei Component of motile flagella 41 0.0045 0.0309 0.0364
Leishmania major hypothetical protein, conserved 0.0208 0.1957 0.2442
Brugia malayi Cathepsin L-like precursor 0.0469 0.4583 0.4807
Trypanosoma cruzi small myristoylated protein 1-2 0.036 0.3482 0.3845
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0562 0.5528 0.6947
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.3261 0.6901
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0174 0.0337
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.049 0.4797 0.5305
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0021 0.0021
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0107 0.093 0.0931
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0107 0.093 0.1937
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.005 0.0053
Plasmodium vivax centrin-1, putative 0.0045 0.0309 0.0643
Loa Loa (eye worm) hypothetical protein 0.0023 0.0083 0.0087
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.049 0.4797 0.5305
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0107 0.093 0.1941
Schistosoma mansoni hypothetical protein 0.0045 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0232
Onchocerca volvulus Cathepsin F homolog 0.0469 0.4583 0.9714
Trypanosoma cruzi cruzipain precursor, putative 0.0562 0.5528 0.6117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0469 0.4583 0.9715
Echinococcus granulosus bloom syndrome protein 0.0022 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0045 0.0309 0.0324
Brugia malayi Matrixin family protein 0.0023 0.0083 0.0087
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0699 0.6907 0.8688
Toxoplasma gondii EF hand domain-containing protein 0.0045 0.0309 0.0633
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0221 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0107 0.093 0.0931
Echinococcus multilocularis tissue type plasminogen activator 0.006 0.0463 0.0463
Leishmania major hypothetical protein, conserved 0.0026 0.0111 0.0114
Brugia malayi Pre-SET motif family protein 0.0061 0.0466 0.0489
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0045 0.0309 0.0321
Onchocerca volvulus 0.0028 0.0135 0.0286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0562 0.5528 0.6947
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0252 0.2399 0.5064
Leishmania major small myristoylated protein-2 0.0655 0.6466 0.813
Plasmodium falciparum cysteine proteinase falcipain 3 0.0469 0.4583 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0221 0.0232
Toxoplasma gondii PAN domain-containing protein 0.0028 0.0135 0.025
Leishmania major hypothetical protein, conserved 0.0208 0.1957 0.2442
Schistosoma mansoni reticulocalbin 0.0045 0.0309 0.0309
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0107 0.093 0.1938
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0232
Schistosoma mansoni ef hand domain family member A2 0.0045 0.0309 0.0309
Echinococcus granulosus cathepsin l1 0.0469 0.4583 0.4583
Leishmania major receptor-type adenylate cyclase a-like protein 0.0208 0.1957 0.2442
Plasmodium falciparum calpain 0.0252 0.2399 0.5212
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0443 0.4321 0.5425
Leishmania major small myristoylated protein 4, putative 0.0567 0.5572 0.7003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0232
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0252 0.2399 0.5064
Onchocerca volvulus 0.0469 0.4583 0.9714
Plasmodium vivax vivapain-1 0.0253 0.2411 0.5026
Mycobacterium tuberculosis Conserved protein 0.0036 0.0221 0.0918
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0562 0.5528 0.6947
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0021 0.0022
Echinococcus granulosus EF hand domain containing family member A2 0.0045 0.0309 0.0309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0107 0.093 0.1937
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.1077 0.4845
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0221 0.0918
Brugia malayi Calmodulin-like protein 0.0045 0.0309 0.0324
Mycobacterium ulcerans hypothetical protein 0.0036 0.0221 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0466 0.0466
Loa Loa (eye worm) PAN domain-containing protein 0.0028 0.0135 0.0141
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0252 0.2399 0.5064
Schistosoma mansoni tar DNA-binding protein 0.0064 0.05 0.05
Echinococcus multilocularis neuronal calcium sensor 0.0045 0.0309 0.0309
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.2411 0.3015
Plasmodium falciparum serine repeat antigen 4 0.0107 0.093 0.1994
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0754 0.7463 0.8267
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.2411 0.509
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0045 0.0309 0.0571
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.4583 0.9715
Brugia malayi Matrixin family protein 0.0023 0.0083 0.0087
Toxoplasma gondii PAN domain-containing protein 0.0028 0.0135 0.025
Echinococcus granulosus calpain 7 C02 family 0.049 0.4797 0.4797
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.4583 0.9715
Trypanosoma cruzi I/6 autoantigen, putative 0.0045 0.0309 0.0321
Loa Loa (eye worm) hypothetical protein 0.0252 0.2399 0.2516
Schistosoma mansoni cathepsin S (C01 family) 0.0107 0.093 0.0931
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0955 0.4282
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0443 0.4321 0.4776
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0021 0.0021
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0416 0.4047 0.4472
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0573 0.5638 0.624
Giardia lamblia Cathepsin B precursor 0.0355 0.3433 1
Trypanosoma cruzi small myristoylated protein 1-1 0.036 0.3482 0.3845
Loa Loa (eye worm) hypothetical protein 0.0107 0.093 0.0976
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0794 0.0795
Toxoplasma gondii PAN domain-containing protein 0.0028 0.0135 0.025
Leishmania major calmodulin, putative 0.0045 0.0309 0.0364
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0466 0.0467
Entamoeba histolytica calcium-binding protein, putative 0.0045 0.0309 0.0571
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0045 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0232
Echinococcus granulosus calpain 0.049 0.4797 0.4797
Echinococcus multilocularis centrin 2 0.0045 0.0309 0.0309
Plasmodium falciparum serine repeat antigen 8 0.0107 0.093 0.1994
Leishmania major hypothetical protein, unknown function 0.0252 0.2399 0.3
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0461 0.4502 0.4978
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0802 0.7948 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0909 0.9023 0.9032
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0045 0.0309 0.0321
Onchocerca volvulus 0.0469 0.4583 0.9714
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0028
Onchocerca volvulus Matrilysin homolog 0.005 0.0362 0.0767
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0253 0.2411 0.2655
Entamoeba histolytica cysteine protease, putative 0.0253 0.2411 0.5208
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0909 0.9023 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0802 0.7948 1
Schistosoma mansoni calpain-7 (C02 family) 0.049 0.4797 0.4802
Giardia lamblia Cathepsin B precursor 0.0107 0.093 0.2665
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0305 0.2927 0.3229
Loa Loa (eye worm) hypothetical protein 0.006 0.0463 0.0486
Leishmania major cysteine peptidase A (CPA) 0.0469 0.4583 0.5755
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0562 0.5528 0.6947
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0469 0.4583 1
Echinococcus granulosus neurocalcin 0.0045 0.0309 0.0309
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.005 0.0038
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.005 0.0038
Loa Loa (eye worm) hypothetical protein 0.0147 0.1334 0.1399
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0174 0.0171
Echinococcus granulosus cathepsin b 0.0909 0.9023 0.9023
Schistosoma mansoni hypothetical protein 0.0052 0.0381 0.0382
Toxoplasma gondii calcium-dependent protein kinase 0.0046 0.0319 0.0654
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0111 0.01
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0107 0.093 0.1938
Onchocerca volvulus 0.0023 0.0083 0.0175
Brugia malayi hypothetical protein 0.0026 0.0111 0.0116
Giardia lamblia Cathepsin B precursor 0.0355 0.3433 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.4583 0.9715
Loa Loa (eye worm) hypothetical protein 0.0322 0.3102 0.3254
Onchocerca volvulus 0.0469 0.4591 0.973
Trypanosoma cruzi hypothetical protein, conserved 0.0208 0.1957 0.2151
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0461 0.4502 0.4978
Schistosoma mansoni DNA polymerase eta 0.0045 0.031 0.0311
Leishmania major hypothetical protein, conserved 0.006 0.0463 0.0559
Entamoeba histolytica hypothetical protein, conserved 0.0046 0.0319 0.0593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.4583 0.9715
Onchocerca volvulus Matrix metalloproteinase homolog 0.005 0.0362 0.0767
Plasmodium vivax serine-repeat antigen (SERA) 0.0107 0.093 0.1938
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0045 0.0309 0.0309
Onchocerca volvulus Cathepsin L homolog 0.0469 0.4583 0.9714
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0129 0.0135
Loa Loa (eye worm) hypothetical protein 0.0028 0.0135 0.0141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0469 0.4583 0.9715
Schistosoma mansoni hypothetical protein 0.0127 0.1139 0.114
Echinococcus granulosus cathepsin L cysteine protease 0.0253 0.2411 0.2411
Giardia lamblia Cysteine protease 0.0107 0.093 0.2665
Brugia malayi cathepsin F-like cysteine proteinase 0.0107 0.093 0.0976
Loa Loa (eye worm) hypothetical protein 0.0322 0.3102 0.3254
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.2411 0.5208
Echinococcus multilocularis cathepsin b 0.0909 0.9023 0.9023
Leishmania major trypanothione reductase 0.0048 0.0336 0.0398
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.1112 0.1166
Trypanosoma brucei calpain-like protein, putative 0.049 0.4797 0.6025
Plasmodium falciparum serine repeat antigen 7 0.0107 0.093 0.1994
Echinococcus granulosus dna polymerase kappa 0.002 0.005 0.005
Onchocerca volvulus 0.0036 0.0221 0.0468
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0028 0.0133 0.0514
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.005 0.0033
Onchocerca volvulus 0.0049 0.0344 0.0729
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.005 0.0038
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0355 0.3433 0.3791
Schistosoma mansoni thyroid hormone receptor 0.0138 0.1242 0.1243
Loa Loa (eye worm) PAN domain-containing protein 0.0028 0.0135 0.0141
Brugia malayi Matrixin family protein 0.0023 0.0083 0.0087
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.005 0.0063
Toxoplasma gondii hypothetical protein 0.0028 0.0135 0.025
Loa Loa (eye worm) hypothetical protein 0.0045 0.031 0.0326
Loa Loa (eye worm) hypothetical protein 0.0028 0.0135 0.0141
Schistosoma mansoni intermediate filament proteins 0.0027 0.0129 0.0129
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0107 0.093 0.1938
Schistosoma mansoni cathepsin C 0.0107 0.093 0.0931
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0107 0.093 0.2665
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.4583 0.9715
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-5 0.0208 0.1957 0.2442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0107 0.093 0.1937
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0107 0.093 0.0931
Entamoeba histolytica cysteine protease, putative 0.0107 0.093 0.1941
Loa Loa (eye worm) TAR-binding protein 0.0064 0.05 0.0524
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0028 0.0133 0.0139
Trypanosoma brucei cysteine peptidase C (CPC) 0.0355 0.3433 0.4305
Giardia lamblia Cysteine protease 0.0107 0.093 0.2665
Schistosoma mansoni tar DNA-binding protein 0.0064 0.05 0.05
Trichomonas vaginalis calmodulin-2, putative 0.0045 0.0309 0.0615
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0221 0.0232
Brugia malayi programmed cell death protein 6 0.0045 0.0309 0.0324
Onchocerca volvulus 0.0061 0.0466 0.0988
Leishmania major META domain containing protein 0.0208 0.1957 0.2442
Brugia malayi PAN domain containing protein 0.0028 0.0135 0.0141
Leishmania major hypothetical protein, conserved 0.0208 0.1957 0.2442
Loa Loa (eye worm) hypothetical protein 0.0026 0.0111 0.0116
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0107 0.093 0.1938
Toxoplasma gondii hypothetical protein 0.0028 0.0135 0.025
Echinococcus granulosus dna polymerase eta 0.0045 0.031 0.031
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0001 0.0001
Giardia lamblia Cathepsin L precursor 0.0107 0.093 0.2665
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0107 0.093 0.1937
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.4583 0.9715
Toxoplasma gondii microneme protein MIC17A 0.0028 0.0135 0.025
Loa Loa (eye worm) hypothetical protein 0.0107 0.093 0.0976
Brugia malayi cathepsin F-like cysteine proteinase 0.0147 0.1334 0.1399
Echinococcus multilocularis Ankyrin 0.0015 0.0001 0.0001
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0107 0.093 0.0931
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0107 0.093 0.1938
Brugia malayi Cathepsin L-like precursor 0.0469 0.4583 0.4807
Mycobacterium ulcerans DNA polymerase IV 0.002 0.005 0.1485
Echinococcus granulosus cathepsin l cysteine peptidase 0.0469 0.4583 0.4583
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0305 0.2927 0.3667
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.1004 0.999 0.999
Entamoeba histolytica cysteine protease, putative 0.0107 0.093 0.1941
Leishmania major hypothetical protein, conserved 0.0045 0.0309 0.0364
Trypanosoma cruzi cysteine peptidase, putative 0.0562 0.5528 0.6117
Trichomonas vaginalis calcium binding protein, putative 0.0045 0.0309 0.0615
Brugia malayi calcium-binding protein 0.0045 0.0309 0.0324
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0045 0.0309 0.0364
Leishmania major kinesin, putative 0.0238 0.2251 0.2814
Giardia lamblia Cathepsin L precursor 0.0107 0.093 0.2665
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1004 0.999 1
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0319 0.0664
Brugia malayi PAN domain containing protein 0.0028 0.0135 0.0141
Toxoplasma gondii subtilisin SUB12 0.0028 0.0135 0.025
Trypanosoma cruzi unspecified product 0.036 0.3482 0.3845
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0107 0.093 0.1938
Trypanosoma cruzi hypothetical protein, conserved 0.0208 0.1957 0.2151
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0469 0.4583 0.4583
Brugia malayi cathepsin L precursor 0.0107 0.093 0.0976
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.2411 0.5208
Entamoeba histolytica cysteine protease, putative 0.0253 0.2411 0.5208
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0045 0.0309 0.0321
Loa Loa (eye worm) hypothetical protein 0.0107 0.093 0.0976
Brugia malayi Papain family cysteine protease containing protein 0.0253 0.2411 0.2529
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0107 0.093 0.1937
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0606 0.5964 0.6602
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0794 0.0833
Loa Loa (eye worm) matrixin family protein 0.005 0.0362 0.038
Loa Loa (eye worm) calpain 0.049 0.4797 0.5031
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.1077 0.4845
Echinococcus granulosus neuronal calcium sensor 0.0045 0.0309 0.0309
Schistosoma mansoni rab 0.0045 0.0309 0.0309
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.005 0.0038
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0221 0.0221
Brugia malayi calpain 7 0.049 0.4797 0.5031
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.093 0.1937
Toxoplasma gondii microneme protein MIC17C 0.0028 0.0135 0.025
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0955 0.4282
Trichomonas vaginalis conserved hypothetical protein 0.0252 0.2399 0.5064
Onchocerca volvulus 0.0028 0.0135 0.0286
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0573 0.5638 0.7086
Schistosoma mansoni neuronal calcium sensor 0.0045 0.0309 0.0309
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0075 0.0605 0.0605
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0107 0.093 0.0976
Toxoplasma gondii PAN domain-containing protein 0.0028 0.0135 0.025
Schistosoma mansoni hypothetical protein 0.0171 0.1583 0.1585
Trichomonas vaginalis calmodulin, putative 0.0053 0.0392 0.079
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0221 0.0427
Loa Loa (eye worm) hypothetical protein 0.0321 0.3093 0.3244
Trichomonas vaginalis calmodulin, putative 0.0046 0.0319 0.0635
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.005 0.0063
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0909 0.9023 0.9032
Onchocerca volvulus 0.0469 0.4583 0.9714
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.005 0.005
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0045 0.0309 0.0571
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0083 0.0687 0.0687
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.005 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.4583 0.9715
Entamoeba histolytica cysteine protease, putative 0.0253 0.2411 0.5208
Leishmania major hypothetical protein, conserved 0.0036 0.0221 0.0253
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0021 0.5
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0336 0.0336
Entamoeba histolytica cysteine protease, putative 0.0107 0.093 0.1941
Echinococcus granulosus calpain 5 0.049 0.4797 0.4797
Trichomonas vaginalis calpain, putative 0.0252 0.2399 0.5064
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0588 0.5783 0.727
Giardia lamblia Cysteine protease 0.0107 0.093 0.2665
Schistosoma mansoni Mername-AA248 (C02 family) 0.049 0.4797 0.4802
Giardia lamblia Encystation-specific protease 0.0107 0.093 0.2665
Trichomonas vaginalis calmodulin, putative 0.0045 0.0309 0.0615
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0466 0.0466
Trichomonas vaginalis calmodulin, putative 0.0045 0.0309 0.0615
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.4583 0.9715
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0021 0.5
Schistosoma mansoni calpain C (C02 family) 0.049 0.4797 0.4802
Plasmodium falciparum serine repeat antigen 6 0.0107 0.093 0.1994
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0955 0.8699
Onchocerca volvulus Matrilysin homolog 0.0023 0.0083 0.0175
Entamoeba histolytica grainin 2 0.0053 0.0392 0.0753
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.005 0.0038
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0955 0.4282
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.005 0.0033
Leishmania major hypothetical protein, conserved 0.047 0.4592 0.5767
Schistosoma mansoni thyroid hormone receptor 0.0138 0.1242 0.1243
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0466 0.0467
Entamoeba histolytica cysteine proteinase 1, putative 0.0253 0.2411 0.5208
Onchocerca volvulus 0.0469 0.4583 0.9714
Brugia malayi Matrixin family protein 0.0055 0.0408 0.0428
Entamoeba histolytica grainin, putative 0.0046 0.0319 0.0593
Trypanosoma cruzi cysteine protease, putative 0.0253 0.2411 0.2655
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0232
Schistosoma mansoni calpain (C02 family) 0.049 0.4797 0.4802
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0754 0.7463 0.9389
Plasmodium vivax vivapain-3 0.0253 0.2411 0.5026
Plasmodium falciparum centrin-1 0.0045 0.0309 0.0633
Loa Loa (eye worm) hypothetical protein 0.0107 0.093 0.0976
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.1112 0.1166
Brugia malayi Death domain containing protein 0.0015 0.000000034185 0.000000035855
Plasmodium vivax calpain, putative 0.049 0.4797 1
Trypanosoma cruzi hypothetical protein, conserved 0.0208 0.1957 0.2151
Brugia malayi Cathepsin L-like cysteine proteinase 0.0322 0.3102 0.3254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.4583 0.9715
Trichomonas vaginalis calpain, putative 0.0252 0.2399 0.5064
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0847 0.8401 0.8401
Echinococcus multilocularis lamin 0.0027 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Trypanosoma cruzi I/6 autoantigen, putative 0.0045 0.0309 0.0321
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.005 0.0033
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0046 0.0319 0.0331
Trypanosoma cruzi cysteine proteinase, putative 0.0253 0.2411 0.2655
Echinococcus multilocularis dna polymerase kappa 0.002 0.005 0.005
Entamoeba histolytica calpain family cysteine protease, putative 0.0252 0.2399 0.5181
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0107 0.093 0.1938
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0107 0.093 0.1937
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0344 0.0361
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.1139 0.1139
Trichomonas vaginalis myosin light chain 1, putative 0.0045 0.0309 0.0615
Brugia malayi Papain family cysteine protease containing protein 0.0107 0.093 0.0976
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0469 0.4583 0.9715
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0001 0.0001
Brugia malayi PAN domain containing protein 0.0028 0.0135 0.0141
Loa Loa (eye worm) glutathione reductase 0.0048 0.0336 0.0352
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0562 0.5528 0.6947
Leishmania major calmodulin, putative 0.0045 0.0309 0.0364
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0562 0.5528 0.6947
Trichomonas vaginalis calcium binding protein, putative 0.0045 0.0309 0.0615
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0147 0.1334 0.1399
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0516 0.5065 0.6363
Leishmania major cathepsin L-like protease 0.0469 0.4583 0.5755
Toxoplasma gondii microneme protein MIC4 0.0028 0.0135 0.025
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0107 0.093 0.1994
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0111 0.0197
Entamoeba histolytica cysteine protease, putative 0.0107 0.093 0.1941
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0461 0.4502 0.4978
Trypanosoma cruzi centrin, putative 0.0053 0.0392 0.0412
Entamoeba histolytica cysteine protease, putative 0.0253 0.2411 0.5208
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0221 0.0221
Echinococcus multilocularis EF hand domain containing family member A2 0.0046 0.0319 0.0319
Echinococcus multilocularis calpain 7 (C02 family) 0.049 0.4797 0.4797
Leishmania major hypothetical protein, conserved 0.0208 0.1957 0.2442
Echinococcus granulosus programmed cell death protein 0.0053 0.0392 0.0392
Entamoeba histolytica cysteine protease, putative 0.0253 0.2411 0.5208
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0516 0.5065 0.6363
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0107 0.093 0.0976
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0221 0.0221
Trichomonas vaginalis calmodulin, putative 0.0045 0.0309 0.0615
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0379 0.368 0.4065
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0221 0.0918
Giardia lamblia Hypothetical protein 0.0046 0.0319 0.0874
Schistosoma mansoni calpain-2 (C02 family) 0.0252 0.2399 0.2401
Leishmania major phospholipase c-like protein 0.0045 0.0309 0.0364
Brugia malayi Papain family cysteine protease containing protein 0.0469 0.4583 0.4807
Leishmania major hypothetical protein, conserved,calpain-like cysteine peptidase, Clan CA, family C2 0.0208 0.1957 0.2442
Trypanosoma brucei kinesin, putative 0.0238 0.2251 0.2814
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0208 0.1957 0.2442
Giardia lamblia DINP protein human, muc B family 0.002 0.005 0.0087
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1004 0.999 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0466 0.0466
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0469 0.4583 0.9715
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0469 0.4583 0.9715
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0147 0.1334 0.1399
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0107 0.093 0.1937
Schistosoma mansoni lamin 0.0027 0.0129 0.0129
Schistosoma mansoni hypothetical protein 0.0045 0.0309 0.0309
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0111 0.0114
Toxoplasma gondii cathepsin CPC2 0.0107 0.093 0.1994
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0071 0.0108
Echinococcus granulosus cathepsin L 0.0253 0.2411 0.2411
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0909 0.9023 0.9032
Echinococcus granulosus cathepsin b 0.0909 0.9023 0.9023
Entamoeba histolytica cysteine protease, putative 0.0469 0.4583 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0264 0.2519 0.3152
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0336 0.1446
Leishmania major DNA polymerase eta, putative 0.0045 0.031 0.0366
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.005 0.005
Brugia malayi Uncoordinated protein 44 0.0015 0.000000034185 0.000000035855
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0443 0.4321 0.4776
Giardia lamblia Cathepsin L precursor 0.0107 0.093 0.2665
Entamoeba histolytica cysteine proteinase, putative 0.0469 0.4583 1
Leishmania major centrin, putative,caltractin, putative 0.0045 0.0309 0.0364
Leishmania major hypothetical protein, conserved 0.0046 0.0319 0.0376
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0107 0.093 0.0976
Giardia lamblia Hypothetical protein 0.0107 0.093 0.2665
Echinococcus multilocularis neurocalcin 0.0045 0.0309 0.0309
Brugia malayi PAN domain containing protein 0.0028 0.0135 0.0141
Entamoeba histolytica calpain large subunit domain III containing protein 0.0238 0.2251 0.4856
Toxoplasma gondii cathepsin CPC1 0.0107 0.093 0.1994
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0129 0.0135
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0221 0.0934
Brugia malayi PAN domain containing protein 0.0028 0.0135 0.0141
Loa Loa (eye worm) hypothetical protein 0.0322 0.3102 0.3254
Loa Loa (eye worm) hypothetical protein 0.0045 0.0309 0.0324
Giardia lamblia Cathepsin L-like protease 0.0107 0.093 0.2665
Loa Loa (eye worm) calpain family protein 1 0.0722 0.7136 0.7485
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0959 0.9534 0.9544
Trypanosoma cruzi major cysteine proteinase, putative 0.02 0.1875 0.206
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0461 0.4502 0.5653
Echinococcus granulosus lamin dm0 0.0027 0.0129 0.0129
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.055 0.5402 0.5978
Trypanosoma brucei centrin, putative 0.0045 0.0309 0.0364
Brugia malayi Papain family cysteine protease containing protein 0.0253 0.2411 0.2529
Trypanosoma cruzi hypothetical protein, conserved 0.0208 0.1957 0.2151
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.005 0.0038
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.005 0.0038
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0221 0.0918
Leishmania major i/6 autoantigen-like protein 0.0045 0.0309 0.0364
Mycobacterium tuberculosis Conserved protein 0.0036 0.0221 0.0918
Onchocerca volvulus 0.0045 0.0309 0.0655
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.005 0.0038
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0253 0.2411 0.2413
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0562 0.5528 0.6947
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0221 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0107 0.093 0.1937
Echinococcus multilocularis calumenin 0.0046 0.0319 0.0319
Schistosoma mansoni hypothetical protein 0.0252 0.2399 0.2401
Onchocerca volvulus 0.0482 0.4718 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0021 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.093 0.1937
Echinococcus multilocularis cathepsin b 0.0909 0.9023 0.9023
Echinococcus granulosus tissue type plasminogen activator 0.006 0.0463 0.0463
Toxoplasma gondii kringle domain-containing protein 0.006 0.0463 0.0971
Schistosoma mansoni calmodulin 0.0045 0.0309 0.0309
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0562 0.5528 0.6947
Plasmodium falciparum serine repeat antigen 1 0.0107 0.093 0.1994
Mycobacterium tuberculosis Probable reductase 0.0109 0.0955 0.4282
Schistosoma mansoni hypothetical protein 0.0049 0.0344 0.0344
Onchocerca volvulus 0.0032 0.0178 0.0378
Brugia malayi Hemopexin family protein 0.0032 0.0178 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0466 0.0467
Brugia malayi Protein kinase domain containing protein 0.0015 0.000000034185 0.000000035855
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.005 0.0136
Schistosoma mansoni reticulocalbin 0.0046 0.0319 0.0319
Echinococcus granulosus nuclear factor of activated T cells 5 0.0075 0.0605 0.0605
Echinococcus granulosus cathepsin L 0.0107 0.093 0.093
Loa Loa (eye worm) RNA binding protein 0.0064 0.05 0.0524
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0107 0.093 0.0931
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.068 0.6719 0.744
Giardia lamblia Cathepsin B precursor 0.0107 0.093 0.2665
Loa Loa (eye worm) hypothetical protein 0.0959 0.9534 1
Toxoplasma gondii EFHC1, putative 0.0045 0.0309 0.0633
Onchocerca volvulus 0.0028 0.0135 0.0286
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0107 0.093 0.1937
Loa Loa (eye worm) PAN domain-containing protein 0.0028 0.0135 0.0141
Trichomonas vaginalis hypothetical protein 0.0252 0.2399 0.5064
Trichomonas vaginalis calpain, putative 0.0252 0.2399 0.5064
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0221 0.0918
Mycobacterium ulcerans hydrolase 0.0028 0.0133 0.5593
Entamoeba histolytica protein kinase, putative 0.0238 0.2251 0.4856
Onchocerca volvulus 0.0046 0.0319 0.0676
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0461 0.4502 0.4978
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0107 0.093 0.1937
Echinococcus granulosus calcium uptake protein 1 0.0046 0.0319 0.0319
Loa Loa (eye worm) ctsf protein 0.0469 0.4583 0.4807
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0107 0.093 0.1938
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0794 0.0795
Echinococcus granulosus geminin 0.0171 0.1583 0.1583
Onchocerca volvulus Cathepsin L homolog 0.0469 0.4583 0.9714
Entamoeba histolytica calcium binding family protein 0.0045 0.0309 0.0571
Plasmodium falciparum cysteine proteinase falcipain 1 0.0253 0.2411 0.524
Entamoeba histolytica calmodulin, putative 0.0045 0.0309 0.0571
Trypanosoma brucei calpain, putative 0.0252 0.2399 0.3
Brugia malayi cathepsin Z-like cysteine proteinase 0.0107 0.093 0.0976
Brugia malayi Cathepsin L-like precursor 0.0469 0.4583 0.4807
Schistosoma mansoni cathepsin F (C01 family) 0.0322 0.3102 0.3105
Echinococcus multilocularis cathepsin L cysteine protease 0.0469 0.4583 0.4583
Entamoeba histolytica cysteine protease, putative 0.0253 0.2411 0.5208
Onchocerca volvulus 0.0028 0.0135 0.0286
Giardia lamblia Cathepsin B precursor 0.0107 0.093 0.2665
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0111 0.0197
Trypanosoma brucei conserved protein 0.0217 0.2047 0.2556
Loa Loa (eye worm) hypothetical protein 0.0147 0.1334 0.1399
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.1004 0.999 0.999
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0909 0.9023 0.9032
Brugia malayi cathepsin Z-like cysteine proteinase 0.0107 0.093 0.0976
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0023 0.0083 0.0083
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0802 0.7948 0.8805
Loa Loa (eye worm) hypothetical protein 0.0023 0.0083 0.0087
Onchocerca volvulus 0.0027 0.0129 0.0273
Schistosoma mansoni hypothetical protein 0.006 0.0463 0.0464
Leishmania major DNA polymerase kappa, putative 0.002 0.005 0.0038
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0107 0.093 0.2665
Brugia malayi calpain D 0.0252 0.2399 0.2516
Loa Loa (eye worm) calpain D 0.0252 0.2399 0.2516
Echinococcus granulosus intermediate filament protein 0.0027 0.0129 0.0129
Brugia malayi hypothetical protein 0.0123 0.1096 0.115
Echinococcus granulosus cathepsin l1 0.0322 0.3102 0.3102
Schistosoma mansoni neuronal calcium sensor 0.0045 0.0309 0.0309
Onchocerca volvulus 0.0028 0.0135 0.0286
Trichomonas vaginalis centrin, putative 0.0045 0.0309 0.0615
Schistosoma mansoni calmodulin related calcium binding protein 0.0045 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0232
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0469 0.4583 0.9715
Schistosoma mansoni lamin 0.0027 0.0129 0.0129
Schistosoma mansoni centrin-related 0.0045 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0107 0.093 0.0976
Echinococcus multilocularis calmodulin 0.0045 0.0309 0.0309
Onchocerca volvulus 0.0045 0.0309 0.0655
Leishmania major cathepsin L-like protease 0.0469 0.4583 0.5755
Loa Loa (eye worm) hypothetical protein 0.0028 0.0135 0.0141
Trypanosoma brucei calpain-like protein, putative 0.049 0.4797 0.6025
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0208 0.1957 0.2151
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0221 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.005 0.0038
Toxoplasma gondii centrin 0.0045 0.0309 0.0633
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0111 0.01
Toxoplasma gondii cathepsin CPL 0.0469 0.4583 1
Toxoplasma gondii centrin, putative 0.0045 0.0309 0.0633
Trypanosoma brucei hypothetical protein, conserved 0.0338 0.3261 0.4088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.2411 0.3015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0107 0.093 0.1937
Echinococcus granulosus EF HAND 1 calcium binding site 0.0045 0.0309 0.0309
Onchocerca volvulus 0.0469 0.4583 0.9714
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0253 0.2411 0.2413
Trypanosoma brucei small myristoylated protein 1-1 0.036 0.3482 0.4366
Brugia malayi fibroinase precursor 0.0107 0.093 0.0976
Brugia malayi Pre-SET motif family protein 0.0423 0.4126 0.4328
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0758 0.7508 0.9445
Brugia malayi PAN domain containing protein 0.0028 0.0135 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.4583 0.9715
Onchocerca volvulus 0.0469 0.4583 0.9714
Loa Loa (eye worm) programmed cell death protein 6 0.0046 0.0319 0.0334
Trypanosoma brucei unspecified product 0.0208 0.1957 0.2442
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0264 0.2519 0.3152
Plasmodium vivax cysteine repeat modular protein 1, putative 0.006 0.0463 0.0965
Loa Loa (eye worm) hypothetical protein 0.0469 0.4591 0.4815
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0045 0.0309 0.0321
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0221 0.0223
Brugia malayi Matrixin family protein 0.0023 0.0083 0.0087
Trypanosoma cruzi cysteine peptidase, putative 0.0562 0.5528 0.6117
Brugia malayi Kringle domain containing protein 0.006 0.0463 0.0486
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.005 0.0136
Echinococcus multilocularis calpain A 0.1005 1 1
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.031 0.0366
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0071 0.0108
Trypanosoma brucei calpain-like protein, putative 0.0754 0.7463 0.9389
Trypanosoma brucei Calpain-like protein CALP1.3 0.0461 0.4502 0.5653
Toxoplasma gondii troponin c, isotype gamma, putative 0.0045 0.0309 0.0633
Schistosoma mansoni tar DNA-binding protein 0.0064 0.05 0.05
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0107 0.093 0.2665
Echinococcus granulosus cathepsin L cysteine proteinase 0.0469 0.4583 0.4583
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.05 0.0524
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0111 0.0197
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0107 0.093 0.1938
Trypanosoma brucei caltractin, putative 0.0053 0.0392 0.0468
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0107 0.093 0.1937
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.005 0.005
Toxoplasma gondii preprocathepsin c precursor, putative 0.0107 0.093 0.1994
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0107 0.093 0.0976
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0309 0.0615
Treponema pallidum NADH oxidase 0.0017 0.0021 0.5
Loa Loa (eye worm) hypothetical protein 0.0107 0.093 0.0976
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0028 0.0135 0.025
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.068 0.6719 0.845
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0107 0.093 0.1994
Toxoplasma gondii hypothetical protein 0.0252 0.2399 0.5212
Echinococcus granulosus cysteine protease 0.0253 0.2411 0.2411
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0252 0.2399 0.5064
Echinococcus multilocularis hypothetical protein 0.049 0.4797 0.4797
Echinococcus granulosus Ankyrin 0.0015 0.0001 0.0001
Trypanosoma brucei Domain of unknown function (DUF1935), putative 0.0208 0.1957 0.2442
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0107 0.093 0.0931
Schistosoma mansoni neuronal calcium sensor 0.0045 0.0309 0.0309
Loa Loa (eye worm) matrixin family protein 0.0055 0.0408 0.0428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0562 0.5528 0.6947
Plasmodium falciparum serine repeat antigen 9 0.0107 0.093 0.1994

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.9285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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