TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 487.6 | Formula: C26H33N9O
H donors: 1 H acceptors: 4 LogP: 2.02 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)C(=O)c1cc(cn1C)Nc1ncc2c(n1)n(C1CCCC1)c(c2)c1ccnn1C
InChi: 1S/C26H33N9O/c1-31-10-12-34(13-11-31)25(36)23-15-19(17-32(23)2)29-26-27-16-18-14-22(21-8-9-28-33(21)3)35(24(18)30-26)20-6-4-5-7-20/h8-9,14-17,20H,4-7,10-13H2,1-3H3,(H,27,29,30)
InChiKey: NDJAPUTXCKBOMQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	aurora kinase A	Starlite/ChEMBL	References
Homo sapiens	aurora kinase B	Starlite/ChEMBL	References
Homo sapiens	cyclin-dependent kinase 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania braziliensis	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium vivax	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma congolense	cdc2-related kinase 3, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma japonicum	Serine/threonine-protein kinase 12, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma cruzi	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania donovani	cell division protein kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium vivax	protein kinase Crk2	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei gambiense	cell division related protein kinase 2, putative,CDC2-related protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Neospora caninum	hypothetical protein	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	cyclin dependent kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	cyclin dependent kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Neospora caninum	CMGC kinase, CDK family TgPK2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania major	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	cdc2-related kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	cell division protein kinase 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	protein kinase , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania mexicana	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma congolense	cdc2-related kinase 1, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium hominis	protein kinase (EC 2.7.1.-) p46XlEg22	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania mexicana	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Theileria parva	cell division control protein 2 related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Kinase, CMGC CDK	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma cruzi	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei gambiense	cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Babesia bovis	cell division control protein 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma japonicum	ko:K02087 cyclin-dependent kinase 1, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma congolense	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Brugia malayi	serine/threonine-protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	cdc2-related kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	cell division protein kinase 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	aurora B kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Toxoplasma gondii	aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania major	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium parvum	Cdc2-like CDK2/CDC28 like protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Brugia malayi	cell division control protein 2 homolog	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium falciparum	protein kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium yoelii	putative protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Kinase, CMGC CDK	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium knowlesi	Cell division control protein 2 homolog	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium hominis	cdc2-like protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania infantum	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania donovani	Aurora I-related kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K02090 cyclin-dependent kinase 5, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium falciparum	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine kinase 12	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K08850 aurora kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania infantum	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania braziliensis	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium parvum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	cyclin dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania donovani	cdc2-related kinase 3, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	cyclin-dependent kinase 3	305 aa	303 aa	32.0 %
Trypanosoma brucei	mitogen-activated protein kinase 5	aurora kinase B	303 aa	299 aa	22.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	AGC family protein kinase	0.0137	0.0449	0.1378
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.0268	0.0265
Toxoplasma gondii	aurora kinase	0.0137	0.0449	0.1387
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0353	0.1906	0.5876
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0353	0.1906	0.5876
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0353	0.1906	0.5876
Trypanosoma brucei	glucosamine 6-phosphate n-acetyltransferase	0.011	0.0268	0.0817
Toxoplasma gondii	cathepsin CPL	0.0353	0.1906	0.588
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.011	0.0268	0.0817
Trypanosoma cruzi	major cysteine proteinase, putative	0.0102	0.0215	0.0212
Leishmania major	cathepsin L-like protease	0.0353	0.1906	0.5509
Onchocerca volvulus		0.0353	0.1906	0.461
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.011	0.0268	0.0265
Entamoeba histolytica	cysteine proteinase, putative	0.0251	0.122	0.6397
Brugia malayi	Cathepsin L-like precursor	0.0251	0.122	0.1027
Entamoeba histolytica	cysteine protease, putative	0.0204	0.09	0.4716
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0353	0.1906	0.5876
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0353	0.1906	0.5876
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0353	0.1906	0.5876
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0268	0.0265
Onchocerca volvulus		0.0353	0.1906	0.461
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0137	0.0449	0.2346
Plasmodium vivax	vivapain-1	0.0204	0.09	0.3614
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0384	0.2112	0.1939
Trypanosoma cruzi	cysteine peptidase, putative	0.0353	0.1906	0.1903
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0384	0.2112	0.2109
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0102	0.0215	0.0654
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0102	0.0215	0.0654
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.09	0.2771
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0552	0.3241	0.3093
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0204	0.09	0.0701
Plasmodium vivax	unspecified product	0.0102	0.0215	0.0001
Trypanosoma cruzi	cysteine peptidase, putative	0.0353	0.1906	0.1903
Leishmania major	cathepsin L-like protease	0.0353	0.1906	0.5509
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1557	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0268	0.0817
Trichomonas vaginalis	hypothetical protein	0.011	0.0268	0.0817
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0102	0.0215	0.0654
Echinococcus multilocularis	cathepsin L cysteine protease	0.0353	0.1906	0.1903
Toxoplasma gondii	cathepsin B	0.0552	0.3241	1
Loa Loa (eye worm)	hypothetical protein	0.0251	0.122	0.1027
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0353	0.1906	0.5876
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0137	0.0449	0.1237
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0384	0.2112	0.2109
Schistosoma mansoni	protein kinase	0.0137	0.0449	0.024
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0552	0.3241	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0353	0.1906	0.5876
Entamoeba histolytica	cysteine protease, putative	0.0204	0.09	0.4716
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0102	0.0215	0.0654
Leishmania major	cysteine peptidase A (CPA)	0.0353	0.1906	0.5509
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0353	0.1906	0.5876
Giardia lamblia	Aurora kinase	0.0137	0.0449	0.0775
Loa Loa (eye worm)	AUR protein kinase	0.0137	0.0449	0.024
Brugia malayi	Cathepsin L-like precursor	0.0353	0.1906	0.1728
Brugia malayi	calpain family protein 1	0.1031	0.6465	0.6387
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0353	0.1906	0.5876
Brugia malayi	Papain family cysteine protease containing protein	0.0353	0.1906	0.1728
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0204	0.09	0.2771
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0251	0.122	0.3759
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0384	0.2112	0.6512
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0353	0.1906	0.5876
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0204	0.09	0.4054
Echinococcus multilocularis	cysteine protease	0.0353	0.1906	0.1903
Brugia malayi	Cathepsin L-like precursor	0.0353	0.1906	0.1728
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0268	0.0265
Trypanosoma brucei	calpain-like protein, putative	0.0384	0.2112	0.6512
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0353	0.1906	0.5876
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1557	1	1
Entamoeba histolytica	cysteine proteinase 2	0.0204	0.09	0.4716
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.1098	0.6915	0.6847
Entamoeba histolytica	cysteine protease, putative	0.0204	0.09	0.4716
Echinococcus granulosus	cathepsin b	0.1557	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0353	0.1906	0.5876
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.011	0.0268	0.0817
Plasmodium vivax	vivapain-2	0.0353	0.1906	0.8914
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0384	0.2112	0.2109
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0204	0.09	0.0701
Echinococcus granulosus	calpain A	0.11	0.6924	0.6923
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.0268	0.0265
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0268	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0353	0.1906	0.1728
Trypanosoma cruzi	aurora B kinase, putative	0.0137	0.0449	0.0446
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0384	0.2112	0.2109
Trypanosoma brucei	antigen, putative	0.0384	0.2112	0.6512
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0268	0.0817
Echinococcus multilocularis	cysteine protease	0.0353	0.1906	0.1903
Giardia lamblia	Cathepsin B precursor	0.0552	0.3241	1
Onchocerca volvulus	Cathepsin F homolog	0.0353	0.1906	0.461
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0384	0.2112	0.2109
Entamoeba histolytica	protein kinase, putative	0.0276	0.1385	0.7263
Plasmodium vivax	vivapain-2	0.0353	0.1906	0.8914
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1557	1	1
Entamoeba histolytica	cysteine protease, putative	0.0102	0.0215	0.1113
Schistosoma mansoni	cathepsin F (C01 family)	0.0353	0.1906	0.1728
Entamoeba histolytica	cysteine protease, putative	0.0102	0.0215	0.1113
Schistosoma mansoni	calpain-7 (C02 family)	0.0384	0.2112	0.1939
Schistosoma mansoni	calpain-2 (C02 family)	0.011	0.0268	0.0054
Trypanosoma cruzi	conserved protein	0.011	0.0268	0.0265
Loa Loa (eye worm)	calpain family protein 1	0.1031	0.6465	0.6387
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0353	0.1906	0.5876
Plasmodium falciparum	calpain	0.011	0.0268	0.0312
Brugia malayi	serine/threonine protein kinase 6	0.0137	0.0449	0.024
Loa Loa (eye worm)	calpain	0.0384	0.2112	0.1939
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0137	0.0449	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0922	0.5727	0.5633
Trichomonas vaginalis	calpain, putative	0.011	0.0268	0.0817
Toxoplasma gondii	hypothetical protein	0.011	0.0268	0.0826
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0353	0.1906	0.5876
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0384	0.2112	0.6512
Loa Loa (eye worm)	hypothetical protein	0.0647	0.3883	0.3749
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0268	0.0265
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0102	0.0215	0.0654
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0204	0.09	0.2771
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1557	1	1
Entamoeba histolytica	cysteine protease, putative	0.0204	0.09	0.4716
Entamoeba histolytica	cysteine proteinase, putative	0.0204	0.09	0.4716
Echinococcus multilocularis	cathepsin b	0.1557	1	1
Entamoeba histolytica	calpain family cysteine protease, putative	0.011	0.0268	0.1391
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.011	0.0268	0.0817
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0102	0.0215	0.0654
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0552	0.3241	0.3239
Entamoeba histolytica	protein kinase , putative	0.0137	0.0449	0.2346
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.0268	0.0265
Trypanosoma brucei	Calpain-like protein CALP1.3	0.011	0.0268	0.0817
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0268	0.0265
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0268	0.0265
Echinococcus multilocularis	hypothetical protein	0.0384	0.2112	0.2109
Loa Loa (eye worm)	fibroinase	0.0353	0.1906	0.1728
Trichomonas vaginalis	AGC family protein kinase	0.0137	0.0449	0.1378
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0102	0.0215	0.1113
Echinococcus multilocularis	calpain A	0.11	0.6924	0.6923
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0384	0.2112	0.2109
Brugia malayi	calpain 7	0.0384	0.2112	0.1939
Trypanosoma brucei	cysteine peptidase, putative	0.011	0.0268	0.0817
Entamoeba histolytica	cysteine protease, putative	0.0102	0.0215	0.1113
Giardia lamblia	Cathepsin B precursor	0.0552	0.3241	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0102	0.0215	0.0654
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0102	0.0215	0.0654
Trichomonas vaginalis	calpain, putative	0.011	0.0268	0.0817
Echinococcus granulosus	cathepsin b	0.1557	1	1
Entamoeba histolytica	cysteine protease, putative	0.0204	0.09	0.4716
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0353	0.1906	0.5876
Leishmania major	cathepsin L-like protease	0.0353	0.1906	0.5509
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0268	0.0265
Leishmania major	protein kinase, putative	0.0137	0.0449	0.0611
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0353	0.1906	0.5876
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0137	0.0449	0.1387
Trypanosoma brucei	kinesin, putative	0.0274	0.1374	0.4233
Brugia malayi	calpain D	0.011	0.0268	0.0054
Brugia malayi	cathepsin L-like precursor	0.0251	0.122	0.1027
Plasmodium vivax	unspecified product	0.0204	0.09	0.3614
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.011	0.0268	0.0265
Loa Loa (eye worm)	calpain D	0.011	0.0268	0.0054
Trypanosoma cruzi	cysteine proteinase, putative	0.0204	0.09	0.0898
Entamoeba histolytica	protein kinase, putative	0.0137	0.0449	0.2346
Echinococcus multilocularis	cathepsin L cysteine protease	0.0353	0.1906	0.1903
Trypanosoma cruzi	kinesin, putative	0.0274	0.1374	0.1371
Trypanosoma cruzi	cysteine peptidase, putative	0.0204	0.09	0.0898
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.0215	0.0654
Brugia malayi	Papain family cysteine protease containing protein	0.0204	0.09	0.0701
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0204	0.09	0.0701
Entamoeba histolytica	cysteine protease, putative	0.0204	0.09	0.4716
Echinococcus multilocularis	aurora kinase A	0.0137	0.0449	0.0446
Loa Loa (eye worm)	cathepsin B	0.0552	0.3241	0.3093
Echinococcus granulosus	cathepsin L	0.0102	0.0215	0.0212
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.1098	0.6915	0.6914
Leishmania major	cathepsin L-like protease	0.0353	0.1906	0.5509
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0251	0.122	0.1027
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0353	0.1906	0.1903
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.0215	0.0654
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0353	0.1906	0.5876
Trypanosoma brucei	hypothetical protein	0.011	0.0268	0.0817
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0353	0.1906	0.5876
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0353	0.1906	0.1903
Echinococcus multilocularis	cathepsin L	0.0204	0.09	0.0898
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.011	0.0268	0.0265
Brugia malayi	Papain family cysteine protease containing protein	0.0204	0.09	0.0701
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0102	0.0215	0.0654
Echinococcus granulosus	cathepsin l1	0.0251	0.122	0.1218
Trichomonas vaginalis	calpain, putative	0.011	0.0268	0.0817
Echinococcus granulosus	aurora kinase A	0.0137	0.0449	0.0446
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0353	0.1906	0.1728
Schistosoma mansoni	cathepsin F (C01 family)	0.0353	0.1906	0.1728
Echinococcus multilocularis	calpain 7 (C02 family)	0.0384	0.2112	0.2109
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0353	0.1906	0.5876
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0102	0.0215	0.1113
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0384	0.2112	0.6202
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0353	0.1906	0.5876
Entamoeba histolytica	cysteine protease, putative	0.0204	0.09	0.4716
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0274	0.1374	0.7204
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.1031	0.6465	0.6387
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0353	0.1906	0.5876
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0102	0.0215	0.0654
Echinococcus granulosus	cysteine protease	0.0204	0.09	0.0898
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0353	0.1906	0.5876
Schistosoma mansoni	calpain-7 (C02 family)	0.0384	0.2112	0.1939
Leishmania major	cathepsin L-like protease	0.0353	0.1906	0.5509
Brugia malayi	Cathepsin L-like precursor	0.0251	0.122	0.1027
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.0268	0.0265
Brugia malayi	serine/threonine-protein kinase 6	0.0137	0.0449	0.024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0102	0.0215	0.0654
Trypanosoma brucei	calpain-like protein, putative	0.0384	0.2112	0.6512
Trichomonas vaginalis	AGC family protein kinase	0.0137	0.0449	0.1378
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0353	0.1906	1
Brugia malayi	Cathepsin L-like precursor	0.0353	0.1906	0.1728
Trypanosoma brucei	Calpain-like protein 2	0.011	0.0268	0.0817
Echinococcus granulosus	cathepsin l1	0.0353	0.1906	0.1903
Trypanosoma brucei	calpain-like protein, putative	0.0384	0.2112	0.6512
Brugia malayi	Cathepsin L-like precursor	0.0353	0.1906	0.1728
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0552	0.3241	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0353	0.1906	0.5876
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0353	0.1906	0.5876
Onchocerca volvulus	Cathepsin L homolog	0.0353	0.1906	0.461
Entamoeba histolytica	protein kinase domain containing protein	0.0137	0.0449	0.2346
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0384	0.2112	0.2109
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.011	0.0268	0.0817
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0353	0.1906	0.5876
Echinococcus granulosus	calpain A	0.0384	0.2112	0.2109
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.011	0.0268	0.0817
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0353	0.1906	0.5876
Loa Loa (eye worm)	hypothetical protein	0.0251	0.122	0.1027
Entamoeba histolytica	cysteine protease, putative	0.0353	0.1906	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0353	0.1906	0.5876
Trypanosoma brucei	Calpain-like protein 1.2	0.011	0.0268	0.0817
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0384	0.2112	0.6202
Trypanosoma brucei	calpain, putative	0.011	0.0268	0.0817
Brugia malayi	calpain 5	0.011	0.0268	0.0054
Toxoplasma gondii	calpain family cysteine protease domain-containing protein	0.011	0.0268	0.0826
Trichomonas vaginalis	AGC family protein kinase	0.0137	0.0449	0.1378
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0353	0.1906	0.5876
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0137	0.0449	0.0446
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0353	0.1906	0.5876
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0102	0.0215	0.0654
Trypanosoma cruzi	cysteine peptidase, putative	0.0353	0.1906	0.1903
Loa Loa (eye worm)	calpain 5	0.0274	0.1374	0.1184
Brugia malayi	serine/threonine kinase 12	0.0137	0.0449	0.024
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1557	1	1
Loa Loa (eye worm)	AUR protein kinase	0.0137	0.0449	0.024
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0102	0.0215	0.0663
Loa Loa (eye worm)	AUR protein kinase	0.0137	0.0449	0.024
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.011	0.0268	0.0817
Schistosoma mansoni	hypothetical protein	0.011	0.0268	0.0054
Schistosoma mansoni	serine/threonine protein kinase	0.0137	0.0449	0.024
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0353	0.1906	1
Leishmania major	cathepsin L-like protease	0.0353	0.1906	0.5509
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0102	0.0215	0.0654
Entamoeba histolytica	cysteine protease, putative	0.0204	0.09	0.4716
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0353	0.1906	0.5876
Trypanosoma brucei	aurora B kinase	0.0137	0.0449	0.1378
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0204	0.09	0.0898
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0251	0.122	0.1218
Loa Loa (eye worm)	hypothetical protein	0.1557	1	1
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0137	0.0449	0.2346
Loa Loa (eye worm)	hypothetical protein	0.011	0.0268	0.0054
Echinococcus granulosus	calpain 7 C02 family	0.0384	0.2112	0.2109
Plasmodium vivax	calpain, putative	0.0384	0.2112	1
Leishmania major	kinesin, putative	0.0274	0.1374	0.3719
Trypanosoma cruzi	cysteine protease, putative	0.0204	0.09	0.0898
Trichomonas vaginalis	conserved hypothetical protein	0.011	0.0268	0.0817
Entamoeba histolytica	cysteine protease, putative	0.0204	0.09	0.4716
Trypanosoma brucei	calpain, putative	0.011	0.0268	0.0817
Schistosoma mansoni	calpain C (C02 family)	0.0384	0.2112	0.1939
Loa Loa (eye worm)	calpain family protein 1	0.0757	0.4621	0.4503
Toxoplasma gondii	cathepsin CPC1	0.0102	0.0215	0.0663
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0353	0.1906	0.1903
Schistosoma mansoni	cathepsin F (C01 family)	0.0251	0.122	0.1027
Loa Loa (eye worm)	hypothetical protein	0.0757	0.4621	0.4503
Onchocerca volvulus		0.0353	0.1906	0.461
Onchocerca volvulus		0.0251	0.122	0.2741
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0137	0.0449	0.2346
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0384	0.2112	0.2109
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0268	0.0817
Echinococcus multilocularis	calpain	0.0384	0.2112	0.2109
Brugia malayi	calpain 5	0.0274	0.1374	0.1184
Onchocerca volvulus	Cathepsin L homolog	0.0353	0.1906	0.461
Trypanosoma brucei	calpain-like protein, putative	0.0384	0.2112	0.6512
Echinococcus multilocularis	cathepsin L	0.0102	0.0215	0.0212
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0353	0.1906	0.5876
Entamoeba histolytica	cysteine protease, putative	0.0204	0.09	0.4716
Loa Loa (eye worm)	hypothetical protein	0.0251	0.122	0.1027
Brugia malayi	calpain family protein 1	0.1031	0.6465	0.6387
Loa Loa (eye worm)	hypothetical protein	0.1031	0.6465	0.6387
Trypanosoma cruzi	cysteine proteinase, putative	0.0204	0.09	0.0898
Onchocerca volvulus		0.0353	0.1906	0.461
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.011	0.0268	0.0265
Entamoeba histolytica	cysteine protease, putative	0.0102	0.0215	0.1113
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0102	0.0215	0.0654
Schistosoma mansoni	calpain (C02 family)	0.0384	0.2112	0.1939
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.0268	0.0265
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0353	0.1906	0.5876
Trypanosoma cruzi	cysteine peptidase, putative	0.0102	0.0215	0.0212
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.011	0.0268	0.0265
Entamoeba histolytica	cysteine protease, putative	0.0102	0.0215	0.1113
Trypanosoma brucei	cytoskeleton-associated protein CAP5.5, putative	0.011	0.0268	0.0817
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0353	0.1906	0.1728
Trypanosoma brucei	Calpain-like protein 1.1	0.011	0.0268	0.0817
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0353	0.1906	0.5876
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0384	0.2112	0.6202
Loa Loa (eye worm)	cysteine protease	0.0353	0.1906	0.1728
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0251	0.122	0.3759
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0353	0.1906	0.5876
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0353	0.1906	1
Entamoeba histolytica	cysteine protease, putative	0.0204	0.09	0.4716
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0102	0.0215	0.0654
Trypanosoma cruzi	cysteine peptidase, putative	0.0353	0.1906	0.1903
Leishmania major	cathepsin L-like protease	0.0353	0.1906	0.5509
Echinococcus multilocularis	calpain 5	0.0384	0.2112	0.2109
Echinococcus granulosus	cathepsin L	0.0204	0.09	0.0898
Brugia malayi	Cathepsin L-like precursor	0.0353	0.1906	0.1728
Entamoeba histolytica	cysteine proteinase, putative	0.0204	0.09	0.4716
Entamoeba histolytica	protein kinase, putative	0.0137	0.0449	0.2346
Entamoeba histolytica	cysteine protease, putative	0.0102	0.0215	0.1113
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0353	0.1906	0.1903
Echinococcus multilocularis	cathepsin b	0.1557	1	1
Onchocerca volvulus		0.0647	0.3883	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.011	0.0268	0.0265
Trypanosoma cruzi	cruzipain precursor, putative	0.0353	0.1906	0.1903
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0102	0.0215	0.0654
Giardia lamblia	Cathepsin B precursor	0.0552	0.3241	1
Echinococcus granulosus	calpain 5	0.0384	0.2112	0.2109
Trypanosoma cruzi	major cysteine proteinase, putative	0.0102	0.0215	0.0212
Trypanosoma cruzi	cruzipain precursor, putative	0.0102	0.0215	0.0212
Onchocerca volvulus		0.0353	0.1906	0.461
Entamoeba histolytica	hypothetical protein	0.0102	0.0215	0.1113
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0552	0.3241	1
Entamoeba histolytica	cysteine proteinase, putative	0.0353	0.1906	1
Onchocerca volvulus		0.0353	0.1906	0.461
Entamoeba histolytica	cysteine proteinase, putative	0.0204	0.09	0.4716
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0384	0.2112	0.2109
Trypanosoma cruzi	kinesin, putative	0.0274	0.1374	0.1371
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0102	0.0215	0.0654
Entamoeba histolytica	cysteine proteinase, putative	0.0204	0.09	0.4716
Plasmodium vivax	vivapain-3	0.0204	0.09	0.3614
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.1098	0.6915	0.6847
Onchocerca volvulus		0.0353	0.1906	0.461
Entamoeba histolytica	cysteine protease, putative	0.0204	0.09	0.4716
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0204	0.09	0.2771
Entamoeba histolytica	cysteine proteinase 1, putative	0.0204	0.09	0.4716
Entamoeba histolytica	cysteine proteinase, putative	0.0353	0.1906	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0353	0.1906	0.5876
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0384	0.2112	0.2109
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.1098	0.6915	0.6914
Leishmania major	cathepsin L-like protease	0.0353	0.1906	0.5509
Loa Loa (eye worm)	ctsf protein	0.0353	0.1906	0.1728
Echinococcus granulosus	cathepsin L cysteine protease	0.0204	0.09	0.0898
Echinococcus multilocularis	calpain family protein 1, d	0.0757	0.4621	0.4619
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.011	0.0268	0.0817
Brugia malayi	Cathepsin L-like precursor	0.0353	0.1906	0.1728
Entamoeba histolytica	cysteine protease, putative	0.0204	0.09	0.4716
Echinococcus granulosus	calpain	0.0384	0.2112	0.2109
Toxoplasma gondii	cathepsin CPC2	0.0102	0.0215	0.0663

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 1 uM	Induction of cell cycle arrest in human HCT116 cells assessed as minimum concentration required for G2/M versus G1 peak ratio over 2	ChEMBL.	22607669
IC50 (binding)	= 0.004 uM	Inhibition of aurora B kinase	ChEMBL.	22607669
IC50 (binding)	= 0.005 uM	Inhibition of aurora A kinase	ChEMBL.	22607669
IC50 (functional)	= 0.59 uM	Antiproliferative activity against human HCT116 cells	ChEMBL.	22607669
IC50 (binding)	= 1.7 uM	Inhibition of CDK1	ChEMBL.	22607669

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	22607669

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2029913

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1657257