TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 227.263 | Formula: C10H14NOPS
H donors: 1 H acceptors: 0 LogP: 2.86 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: CC1(C)COP(=S)(N1)c1ccccc1
InChi: 1S/C10H14NOPS/c1-10(2)8-12-13(14,11-10)9-6-4-3-5-7-9/h3-7H,8H2,1-2H3,(H,11,14)
InChiKey: AGJPPRCBOFKBLF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	kinesin, putative	0.0396	0.1683	0.1807
Brugia malayi	Cathepsin L-like precursor	0.0486	0.2304	0.2474
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.017	0.0137	0.0147
Trypanosoma cruzi	cysteine protease, putative	0.0277	0.0867	0.0931
Brugia malayi	Cathepsin L-like precursor	0.0336	0.1275	0.1369
Plasmodium vivax	vivapain-1	0.0277	0.0867	0.3044
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.017	0.0137	0.0147
Loa Loa (eye worm)	hypothetical protein	0.017	0.0137	0.0147
Echinococcus granulosus	cathepsin l1	0.0486	0.2304	0.1951
Loa Loa (eye worm)	calpain 5	0.0396	0.1683	0.1807
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0486	0.2304	0.1951
Loa Loa (eye worm)	ctsf protein	0.0486	0.2304	0.2474
Echinococcus multilocularis	calpain A	0.1609	1	1
Echinococcus granulosus	cathepsin L	0.0277	0.0867	0.0448
Schistosoma mansoni	cathepsin F (C01 family)	0.0336	0.1275	0.1278
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0277	0.0867	0.337
Schistosoma mansoni	caspase-7 (C14 family)	0.031	0.1094	0.1096
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0486	0.2304	0.1951
Onchocerca volvulus		0.0486	0.2304	0.251
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0336	0.1275	0.4325
Leishmania major	cysteine peptidase A (CPA)	0.0486	0.2304	0.7991
Brugia malayi	Cathepsin L-like precursor	0.0486	0.2304	0.2474
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0486	0.2304	0.1951
Echinococcus granulosus	cathepsin b	0.1509	0.9315	0.9283
Trypanosoma brucei	antigen, putative	0.0566	0.2849	1
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.017	0.0137	0.0147
Echinococcus multilocularis	cathepsin L	0.0277	0.0867	0.0448
Entamoeba histolytica	cysteine protease, putative	0.0277	0.0867	0.337
Entamoeba histolytica	cysteine protease, putative	0.0277	0.0867	0.337
Entamoeba histolytica	cysteine protease, putative	0.0277	0.0867	0.337
Loa Loa (eye worm)	hypothetical protein	0.0934	0.5373	0.5768
Trypanosoma brucei	calpain-like protein, putative	0.0566	0.2849	1
Brugia malayi	Papain family cysteine protease containing protein	0.0486	0.2304	0.2474
Loa Loa (eye worm)	hypothetical protein	0.133	0.8085	0.868
Entamoeba histolytica	cysteine proteinase 1, putative	0.0277	0.0867	0.337
Schistosoma mansoni	calpain (C02 family)	0.0566	0.2849	0.2854
Schistosoma mansoni	hypothetical protein	0.017	0.0137	0.0137
Onchocerca volvulus		0.0486	0.2304	0.251
Brugia malayi	calpain family protein 1	0.15	0.9251	0.9931
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0566	0.2849	0.3059
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0486	0.2304	0.8232
Brugia malayi	cathepsin B-like cysteine proteinase	0.1509	0.9315	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0486	0.2304	0.2474
Schistosoma mansoni	calpain-7 (C02 family)	0.0566	0.2849	0.2854
Trypanosoma brucei	calpain-like protein, putative	0.0566	0.2849	1
Echinococcus multilocularis	cathepsin b	0.1509	0.9315	0.9283
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0566	0.2849	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.017	0.0137	0.0147
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0486	0.2304	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0566	0.2849	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.017	0.0137	0.0147
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0566	0.2849	0.3059
Entamoeba histolytica	cysteine proteinase 2	0.0277	0.0867	0.337
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1509	0.9315	0.9332
Entamoeba histolytica	cysteine protease, putative	0.0277	0.0867	0.337
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1509	0.9315	1
Entamoeba histolytica	cysteine protease, putative	0.0277	0.0867	0.337
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1509	0.9315	0.9332
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0277	0.0867	0.0869
Echinococcus multilocularis	cathepsin b	0.1509	0.9315	0.9283
Brugia malayi	Cathepsin L-like precursor	0.0486	0.2304	0.2474
Loa Loa (eye worm)	cathepsin B	0.0554	0.2769	0.2973
Plasmodium vivax	vivapain-2	0.0486	0.2304	0.8088
Entamoeba histolytica	cysteine protease, putative	0.0277	0.0867	0.337
Toxoplasma gondii	cathepsin CPL	0.0486	0.2304	0.8232
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0486	0.2304	0.8232
Entamoeba histolytica	cysteine protease, putative	0.0277	0.0867	0.337
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0554	0.2769	1
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.031	0.1094	0.0685
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0486	0.2304	0.1951
Brugia malayi	calpain family protein 1	0.15	0.9251	0.9931
Entamoeba histolytica	cysteine protease, putative	0.0486	0.2304	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0486	0.2304	0.2308
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.017	0.0137	0.0147
Trypanosoma cruzi	conserved protein	0.017	0.0137	0.0147
Trypanosoma cruzi	cysteine peptidase, putative	0.0486	0.2304	0.2474
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0486	0.2304	0.8232
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0277	0.0867	0.2774
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0486	0.2304	0.8232
Trypanosoma brucei	calpain-like protein, putative	0.0566	0.2849	1
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0396	0.1683	0.7135
Giardia lamblia	Cathepsin B precursor	0.0554	0.2769	0.5
Leishmania major	cathepsin L-like protease	0.0486	0.2304	0.7991
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0566	0.2849	0.3059
Plasmodium vivax	vivapain-2	0.0486	0.2304	0.8088
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0566	0.2849	0.3059
Entamoeba histolytica	cysteine protease, putative	0.0277	0.0867	0.337
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0566	0.2849	0.2854
Onchocerca volvulus		0.0486	0.2304	0.251
Plasmodium vivax	vivapain-3	0.0277	0.0867	0.3044
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1509	0.9315	0.9332
Brugia malayi	calpain 7	0.0566	0.2849	0.3059
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0486	0.2304	0.8232
Onchocerca volvulus	Cathepsin F homolog	0.0486	0.2304	0.251
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.1606	0.9981	0.998
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0277	0.0867	0.2693
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0486	0.2304	0.8232
Loa Loa (eye worm)	cysteine protease	0.0486	0.2304	0.2474
Brugia malayi	Cathepsin L-like precursor	0.0486	0.2304	0.2474
Loa Loa (eye worm)	hypothetical protein	0.0336	0.1275	0.1369
Entamoeba histolytica	cysteine proteinase, putative	0.0277	0.0867	0.337
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0486	0.2304	0.8232
Brugia malayi	Cathepsin L-like precursor	0.0336	0.1275	0.1369
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0486	0.2304	0.8232
Schistosoma mansoni	cathepsin F (C01 family)	0.0486	0.2304	0.2308
Onchocerca volvulus		0.0486	0.2304	0.251
Trypanosoma cruzi	cysteine peptidase, putative	0.0486	0.2304	0.2474
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0486	0.2304	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0486	0.2304	0.8232
Brugia malayi	calpain 5	0.017	0.0137	0.0147
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.017	0.0137	0.0147
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0554	0.2769	0.9707
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.017	0.0137	0.0147
Brugia malayi	calpain D	0.017	0.0137	0.0147
Echinococcus multilocularis	cathepsin L cysteine protease	0.0486	0.2304	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0336	0.1275	0.1369
Schistosoma mansoni	calpain C (C02 family)	0.0566	0.2849	0.2854
Leishmania major	cathepsin L-like protease	0.0486	0.2304	0.7991
Echinococcus granulosus	cathepsin b	0.1509	0.9315	0.9283
Echinococcus multilocularis	cysteine protease	0.0486	0.2304	0.1951
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0486	0.2304	0.7991
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0277	0.0867	0.0869
Loa Loa (eye worm)	calpain	0.0566	0.2849	0.3059
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0277	0.0867	0.0931
Echinococcus multilocularis	calpain	0.0566	0.2849	0.252
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0486	0.2304	0.7991
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0566	0.2849	1
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.017	0.0137	0.0147
Echinococcus granulosus	cathepsin L cysteine protease	0.0277	0.0867	0.0448
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0566	0.2849	0.3059
Entamoeba histolytica	cysteine proteinase, putative	0.0277	0.0867	0.337
Trypanosoma cruzi	cysteine peptidase, putative	0.0486	0.2304	0.2474
Onchocerca volvulus		0.0486	0.2304	0.251
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0566	0.2849	0.3059
Echinococcus multilocularis	cysteine protease	0.0486	0.2304	0.1951
Echinococcus granulosus	calpain	0.0566	0.2849	0.252
Giardia lamblia	Cathepsin B precursor	0.0554	0.2769	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0486	0.2304	0.7991
Onchocerca volvulus		0.0934	0.5373	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.1606	0.9981	1
Leishmania major	cathepsin L-like protease	0.0486	0.2304	0.7991
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.017	0.0137	0.0147
Schistosoma mansoni	caspase-3 (C14 family)	0.031	0.1094	0.1096
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0566	0.2849	0.3059
Entamoeba histolytica	cysteine protease, putative	0.0277	0.0867	0.337
Loa Loa (eye worm)	fibroinase	0.0486	0.2304	0.2474
Loa Loa (eye worm)	hypothetical protein	0.1104	0.6539	0.702
Plasmodium vivax	unspecified product	0.0277	0.0867	0.3044
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0486	0.2304	0.7991
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0486	0.2304	0.8232
Schistosoma mansoni	calpain-7 (C02 family)	0.0566	0.2849	0.2854
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0486	0.2304	0.8232
Loa Loa (eye worm)	hypothetical protein	0.1509	0.9315	1
Echinococcus multilocularis	caspase	0.031	0.1094	0.0685
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0486	0.2304	0.2474
Trypanosoma cruzi	cysteine proteinase, putative	0.0277	0.0867	0.0931
Entamoeba histolytica	cysteine proteinase, putative	0.0277	0.0867	0.337
Echinococcus granulosus	cysteine protease	0.0277	0.0867	0.0448
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1509	0.9315	0.9332
Leishmania major	cathepsin L-like protease	0.0486	0.2304	0.7991
Entamoeba histolytica	cysteine protease, putative	0.0277	0.0867	0.337
Trypanosoma brucei	kinesin, putative	0.0396	0.1683	0.5701
Brugia malayi	Cathepsin L-like precursor	0.0486	0.2304	0.2474
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0277	0.0867	0.2774
Loa Loa (eye worm)	hypothetical protein	0.15	0.9251	0.9931
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.15	0.9251	0.9268
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0336	0.1275	0.1369
Trypanosoma cruzi	cysteine proteinase, putative	0.0277	0.0867	0.0931
Onchocerca volvulus	Cathepsin L homolog	0.0486	0.2304	0.251
Brugia malayi	Cathepsin L-like precursor	0.0486	0.2304	0.2474
Echinococcus granulosus	calpain 7 C02 family	0.0566	0.2849	0.252
Leishmania major	kinesin, putative	0.0396	0.1683	0.5701
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0566	0.2849	1
Plasmodium vivax	calpain, putative	0.0566	0.2849	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.017	0.0137	0.0147
Echinococcus granulosus	cathepsin l1	0.0336	0.1275	0.0875
Trypanosoma cruzi	cysteine peptidase, putative	0.0486	0.2304	0.2474
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0486	0.2304	0.8232
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0486	0.2304	0.8232
Echinococcus multilocularis	calpain 5	0.0566	0.2849	0.252
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0277	0.0867	0.0869
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0486	0.2304	0.7991
Entamoeba histolytica	cysteine proteinase, putative	0.0277	0.0867	0.337
Leishmania major	cathepsin L-like protease	0.0486	0.2304	0.7991
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0486	0.2304	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0486	0.2304	0.7991
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0336	0.1275	0.4325
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0566	0.2849	0.3059
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0486	0.2304	0.8232
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0486	0.2304	0.7991
Entamoeba histolytica	cysteine proteinase, putative	0.0486	0.2304	1
Echinococcus multilocularis	hypothetical protein	0.0566	0.2849	0.252
Entamoeba histolytica	cysteine proteinase, putative	0.0486	0.2304	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0486	0.2304	0.8232
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0277	0.0867	0.2693
Leishmania major	cathepsin L-like protease	0.0486	0.2304	0.7991
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.017	0.0137	0.0147
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.017	0.0137	0.0147
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.017	0.0137	0.0147
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.1606	0.9981	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.017	0.0137	0.0147
Entamoeba histolytica	protein kinase, putative	0.0396	0.1683	0.7135
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0486	0.2304	0.7991
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0486	0.2304	0.8232
Onchocerca volvulus		0.0486	0.2304	0.251
Brugia malayi	Papain family cysteine protease containing protein	0.0277	0.0867	0.0931
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.017	0.0137	0.0147
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0554	0.2769	0.2973
Entamoeba histolytica	cysteine proteinase, putative	0.0336	0.1275	0.5253
Echinococcus multilocularis	calpain family protein 1, d	0.1104	0.6539	0.638
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0486	0.2304	0.8232
Loa Loa (eye worm)	calpain family protein 1	0.1104	0.6539	0.702
Echinococcus granulosus	calpain 5	0.0566	0.2849	0.252
Echinococcus granulosus	caspase	0.031	0.1094	0.0685
Entamoeba histolytica	cysteine protease, putative	0.0277	0.0867	0.337
Brugia malayi	calpain 5	0.0396	0.1683	0.1807
Echinococcus granulosus	calpain A	0.0566	0.2849	0.252
Giardia lamblia	Cathepsin B precursor	0.0554	0.2769	0.5
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.017	0.0137	0.0147
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.1606	0.9981	0.998
Trypanosoma cruzi	cysteine peptidase, putative	0.0277	0.0867	0.0931
Entamoeba histolytica	cysteine protease, putative	0.0277	0.0867	0.337
Brugia malayi	cathepsin L-like precursor	0.0336	0.1275	0.1369
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0486	0.2304	0.8232
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.017	0.0137	0.0147
Echinococcus multilocularis	calpain 7 (C02 family)	0.0566	0.2849	0.252
Schistosoma mansoni	calpain-2 (C02 family)	0.017	0.0137	0.0137
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0336	0.1275	0.1369
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0486	0.2304	0.8232
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0566	0.2849	1
Onchocerca volvulus	Cathepsin L homolog	0.0486	0.2304	0.251
Entamoeba histolytica	cysteine protease, putative	0.0277	0.0867	0.337
Leishmania major	cathepsin L-like protease	0.0486	0.2304	0.7991
Loa Loa (eye worm)	calpain family protein 1	0.15	0.9251	0.9931
Trypanosoma cruzi	kinesin, putative	0.0396	0.1683	0.1807
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0486	0.2304	0.8232
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.031	0.1094	0.0685
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0554	0.2769	0.9707
Leishmania major	cathepsin L-like protease	0.0486	0.2304	0.7991
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0554	0.2769	0.2775
Loa Loa (eye worm)	hypothetical protein	0.0486	0.2304	0.2474
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0486	0.2304	0.7991
Brugia malayi	Papain family cysteine protease containing protein	0.0277	0.0867	0.0931
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0486	0.2304	0.8232
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0486	0.2304	0.8232
Loa Loa (eye worm)	hypothetical protein	0.0336	0.1275	0.1369
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0486	0.2304	0.8232
Toxoplasma gondii	cathepsin B	0.0554	0.2769	1
Onchocerca volvulus		0.0486	0.2304	0.251
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0566	0.2849	0.3059
Loa Loa (eye worm)	calpain D	0.017	0.0137	0.0147
Trypanosoma cruzi	cruzipain precursor, putative	0.0486	0.2304	0.2474
Echinococcus multilocularis	cathepsin L cysteine protease	0.0486	0.2304	0.1951
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0486	0.2304	0.8232
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0566	0.2849	0.3059
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0486	0.2304	0.7991
Trypanosoma brucei	calpain-like protein, putative	0.0566	0.2849	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0486	0.2304	0.8232
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0486	0.2304	0.7991

Activities

Activity type	Activity value	Assay description	Source	Reference
Anticonvulsant activity (functional)		In vivo anticonvulsant activity of the compound against electric shock induced seizures(MES) in mice 0.5 hr after ip administration; active at 600 mg/kg	ChEMBL.	6325692
Anticonvulsant activity (functional)		In vivo anticonvulsant activity against pentylene tetrazole seizure threshold(SMC) in mice 0.5 hr after sc administration; inactive at 600 mg/kg	ChEMBL.	6325692
Anticonvulsant activity (functional)		In vivo anticonvulsant activity against pentylene tetrazole seizure threshold(SMC) in mice 4 hr after sc administration; inactive at 600 mg/kg	ChEMBL.	6325692
Anticonvulsant activity (functional)		In vivo anticonvulsant activity against electric shock induced seizures(MES) in mice 4 hr after ip administration; inactive at 600 mg/kg	ChEMBL.	6325692
Anticonvulsant activity (functional)	0	In vivo anticonvulsant activity of the compound against electric shock induced seizures(MES) in mice 0.5 hr after ip administration; active at 600 mg/kg	ChEMBL.	6325692
Anticonvulsant activity (functional)	NT 0	In vivo anticonvulsant activity against electric shock induced seizures(MES) in mice 4 hr after ip administration; inactive at 600 mg/kg	ChEMBL.	6325692
Anticonvulsant activity (functional)	NT 0	In vivo anticonvulsant activity against pentylene tetrazole seizure threshold(SMC) in mice 0.5 hr after sc administration; inactive at 600 mg/kg	ChEMBL.	6325692
Anticonvulsant activity (functional)	NT 0	In vivo anticonvulsant activity against pentylene tetrazole seizure threshold(SMC) in mice 4 hr after sc administration; inactive at 600 mg/kg	ChEMBL.	6325692
Inhibition (binding)	= 15 %	Displacement of [3H]-GABA from GABA-B binding sites in brain homogenates (relative to 100 uM baclofen) at 100 uM	ChEMBL.	6325692
Inhibition (binding)	= 15 %	Displacement of [3H]-GABA from GABA-B binding sites in brain homogenates (relative to 100 uM baclofen) at 100 uM	ChEMBL.	6325692
Toxicity (ADMET)		In vivo neurotoxicity at 600mg/kg, number of animals exhibiting neurotoxicity in the rotorod test / number of animals tested at 0.5 hr	ChEMBL.	6325692
Toxicity (ADMET)		In vivo neurotoxicity at 600mg/kg, number of animals exhibiting neurotoxicity in the rotorod test / number of animals tested 4 hr	ChEMBL.	6325692
Toxicity (ADMET)	0	In vivo neurotoxicity at 600mg/kg, number of animals exhibiting neurotoxicity in the rotorod test / number of animals tested at 0.5 hr	ChEMBL.	6325692
Toxicity (ADMET)	0	In vivo neurotoxicity at 600mg/kg, number of animals exhibiting neurotoxicity in the rotorod test / number of animals tested 4 hr	ChEMBL.	6325692

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL160410

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 272530