TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 293.36 | Formula: C10H15NO5S2
H donors: 0 H acceptors: 5 LogP: 1.63 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC(CS(=O)(=O)c1cccc(n1)OS(=O)(=O)C)C
InChi: 1S/C10H15NO5S2/c1-8(2)7-18(14,15)10-6-4-5-9(11-10)16-17(3,12)13/h4-6,8H,7H2,1-3H3
InChiKey: FVNMINQJTGPNFQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Nephotettix cincticeps	Ace-orthologous acetylcholinesterase	Starlite/ChEMBL	No references
Musca domestica	Acetylcholinesterase	Starlite/ChEMBL	No references
Bos taurus	Acetylcholinesterase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Brugia malayi	Carboxylesterase family protein	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus multilocularis	carboxylesterase 5A	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma japonicum	Acetylcholinesterase 1 precursor, putative	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	carboxylesterase 5A	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	carboxylesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma japonicum	ko:K01049 acetylcholinesterase [EC3.1.1.7], putative	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Brugia malayi	Carboxylesterase family protein	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus multilocularis	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	acetylcholinesterase 1	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126875	All targets in OG5_126875

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Acetylcholinesterase	613 aa	552 aa	31.3 %
Onchocerca volvulus		Acetylcholinesterase	613 aa	565 aa	26.0 %
Brugia malayi	Carboxylesterase family protein	Acetylcholinesterase	613 aa	491 aa	26.7 %
Onchocerca volvulus		Acetylcholinesterase	613 aa	613 aa	26.8 %
Onchocerca volvulus	Putative nuclear protein	Acetylcholinesterase	613 aa	572 aa	41.6 %
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	Acetylcholinesterase	613 aa	601 aa	23.6 %
Brugia malayi	Carboxylesterase family protein	Acetylcholinesterase	613 aa	569 aa	31.3 %
Loa Loa (eye worm)	hypothetical protein	Acetylcholinesterase	613 aa	573 aa	26.5 %
Echinococcus multilocularis	BC026374 protein (S09 family)	Acetylcholinesterase	613 aa	627 aa	33.8 %
Drosophila melanogaster	CG10175 gene product from transcript CG10175-RE	Acetylcholinesterase	613 aa	527 aa	32.3 %
Echinococcus multilocularis	neuroligin	Acetylcholinesterase	613 aa	534 aa	23.2 %
Loa Loa (eye worm)	hypothetical protein	Acetylcholinesterase	613 aa	561 aa	24.6 %
Onchocerca volvulus	Molybdopterin synthase catalytic subunit homolog	Acetylcholinesterase	613 aa	564 aa	30.3 %
Onchocerca volvulus	Carnitine O-palmitoyltransferase 2, mitochondrial homolog	Acetylcholinesterase	613 aa	511 aa	39.9 %
Echinococcus granulosus	BC026374 protein S09 family	Acetylcholinesterase	613 aa	627 aa	34.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	dual specificity	0.0497	0.7416	0.7391
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0145	0.1169	0.0868
Echinococcus multilocularis	allatostatin A receptor	0.0145	0.1169	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0115	0.0631	0.0412
Schistosoma mansoni	neuropeptide receptor	0.0145	0.1169	0.0868
Onchocerca volvulus		0.0145	0.1169	1
Echinococcus granulosus	neuropeptide Y receptor	0.0145	0.1169	0.0868
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0145	0.1169	0.0868
Schistosoma mansoni	growth hormone secretagogue receptor	0.0145	0.1169	0.0868
Schistosoma mansoni	biogenic amine receptor	0.0145	0.1169	0.0868
Echinococcus granulosus	rhodopsin orphan GPCR	0.0145	0.1169	0.0868
Brugia malayi	Protein kinase domain containing protein	0.0115	0.0631	0.0599
Schistosoma mansoni	amine GPCR	0.0145	0.1169	0.0868
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0145	0.1169	0.1145
Brugia malayi	endochitinase	0.0092	0.0214	0.0177
Brugia malayi	neuropeptide F receptor	0.0145	0.1169	0.1145
Brugia malayi	putative neuropeptide receptor	0.0145	0.1169	0.1145
Schistosoma mansoni	hypothetical protein	0.0145	0.1169	0.0868
Trypanosoma brucei	Mitogen-activated protein kinase 10, putative	0.0115	0.0631	0.0412
Trichomonas vaginalis	CMGC family protein kinase	0.0497	0.7416	1
Brugia malayi	hypothetical protein	0.0145	0.1169	0.1145
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0145	0.1169	0.0868
Brugia malayi	hypothetical protein	0.0145	0.1169	0.1145
Echinococcus granulosus	tm gpcr rhodopsin	0.0145	0.1169	0.0868
Echinococcus granulosus	somatostatin receptor	0.0145	0.1169	0.0868
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0145	0.1169	0.1145
Echinococcus granulosus	g protein coupled receptor	0.0145	0.1169	0.0868
Onchocerca volvulus		0.0145	0.1169	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0254	0.0254
Echinococcus multilocularis	Hepatocellular carcinoma associated antigen 59	0.013	0.0891	0.0577
Echinococcus granulosus	mitogen activated protein kinase 15	0.0115	0.0631	0.0305
Onchocerca volvulus		0.0145	0.1169	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0145	0.1169	0.1145
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0638	0.9915	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0145	0.1169	0.0868
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0145	0.1169	0.0868
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0145	0.1169	0.0868
Echinococcus granulosus	hypothetical protein	0.0145	0.1169	0.0868
Echinococcus granulosus	rhodopsin orphan GPCR	0.0145	0.1169	0.0868
Brugia malayi	Dopamine receptor protein 1	0.0145	0.1169	0.1145
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0145	0.1169	0.0868
Echinococcus granulosus	neuropeptide receptor	0.0145	0.1169	0.0868
Loa Loa (eye worm)	TYRA-2 protein	0.0145	0.1169	0.1169
Echinococcus multilocularis	g protein coupled receptor	0.0145	0.1169	0.0868
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0145	0.1169	0.0868
Echinococcus granulosus	g-protein coupled receptor	0.0145	0.1169	0.0868
Trichomonas vaginalis	CMGC family protein kinase	0.0497	0.7416	1
Onchocerca volvulus	Putative endochitinase	0.0092	0.0214	0.1547
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Brugia malayi	GnHR receptor homolog	0.0145	0.1169	0.1145
Entamoeba histolytica	protein kinase, putative	0.0099	0.0339	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0462	0.6785	0.6785
Schistosoma mansoni	hypothetical protein	0.0145	0.1169	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Echinococcus granulosus	rhodopsin orphan GPCR	0.0145	0.1169	0.0868
Brugia malayi	hypothetical protein	0.0145	0.1169	0.1145
Onchocerca volvulus	Putative endochitinase	0.0092	0.0214	0.1547
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0145	0.1169	0.0868
Brugia malayi	GSG2	0.0638	0.9915	1
Loa Loa (eye worm)	haspin protein kinase	0.0638	0.9915	0.9915
Schistosoma mansoni	biogenic amine receptor	0.0145	0.1169	0.0868
Entamoeba histolytica	hypothetical protein	0.011	0.0545	0.0687
Trichomonas vaginalis	CMGC family protein kinase	0.0497	0.7416	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0145	0.1169	0.0868
Echinococcus granulosus	biogenic amine 5HT receptor	0.0145	0.1169	0.0868
Loa Loa (eye worm)	chitinase I	0.0082	0.0039	0.0039
Plasmodium falciparum	conserved protein, unknown function	0.013	0.0891	1
Brugia malayi	G protein-coupled receptor	0.0145	0.1169	0.1145
Trichomonas vaginalis	CMGC family protein kinase	0.0497	0.7416	1
Schistosoma mansoni	adenoreceptor	0.0145	0.1169	0.0868
Schistosoma mansoni	opsin-like receptor	0.0145	0.1169	0.0868
Loa Loa (eye worm)	neuropeptide F receptor	0.0145	0.1169	0.1169
Leishmania major	protein kinase, putative,dual-specificity protein kinase, putative	0.0497	0.7416	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0115	0.0631	0.0412
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0145	0.1169	0.0868
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0145	0.1169	0.0868
Loa Loa (eye worm)	haspin protein kinase	0.0638	0.9915	0.9915
Echinococcus granulosus	tm gpcr rhodopsin	0.0145	0.1169	0.0868
Brugia malayi	Protein kinase domain containing protein	0.0099	0.0339	0.0304
Brugia malayi	Carboxylesterase family protein	0.0462	0.6785	0.6831
Schistosoma mansoni	histamine h1 receptor	0.0145	0.1169	0.0868
Echinococcus granulosus	tm gpcr rhodopsin	0.0145	0.1169	0.0868
Echinococcus granulosus	neuropeptide receptor A26	0.0145	0.1169	0.0868
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0145	0.1169	0.1145
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0462	0.6785	0.6731
Echinococcus multilocularis	dual specificity	0.0497	0.7416	0.7391
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Brugia malayi	hypothetical protein	0.0145	0.1169	0.1145
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0145	0.1169	0.0868
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0145	0.1169	0.0868
Schistosoma mansoni	opsin-like receptor	0.0145	0.1169	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Loa Loa (eye worm)	acetylcholinesterase 1	0.0462	0.6785	0.6785
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Echinococcus multilocularis	dro:myosuppressin receptor	0.0145	0.1169	0.0868
Brugia malayi	hypothetical protein	0.0145	0.1169	0.1145
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Echinococcus granulosus	Hepatocellular carcinoma associated antigen 59	0.013	0.0891	0.0577
Brugia malayi	hypothetical protein	0.0638	0.9915	1
Echinococcus granulosus	dual specificity	0.0497	0.7416	0.7391
Brugia malayi	G protein-coupled receptor F59B2.13	0.0145	0.1169	0.1145
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0145	0.1169	0.0868
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0145	0.1169	0.0868
Echinococcus granulosus	carboxylesterase 5A	0.0462	0.6785	0.6731
Onchocerca volvulus		0.0145	0.1169	1
Echinococcus granulosus	neuropeptides capa receptor	0.0145	0.1169	0.0868
Echinococcus multilocularis	orexin receptor type 2	0.0145	0.1169	0.0868
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0145	0.1169	0.0868
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0145	0.1169	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Echinococcus granulosus	fmrfamide receptor	0.0145	0.1169	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Brugia malayi	ORL1-like opioid receptor	0.0145	0.1169	0.1145
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0145	0.1169	0.0868
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0638	0.9915	1
Schistosoma mansoni	serine/threonine protein kinase	0.0497	0.7416	0.7391
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0145	0.1169	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Echinococcus granulosus	acetylcholinesterase	0.0462	0.6785	0.6731
Echinococcus multilocularis	sex peptide receptor	0.0145	0.1169	0.0868
Brugia malayi	G-protein coupled receptor	0.0145	0.1169	0.1145
Brugia malayi	cyclin-dependent kinase 7 homolog	0.0115	0.0631	0.0599
Onchocerca volvulus		0.0145	0.1169	1
Echinococcus granulosus	sex peptide receptor	0.0145	0.1169	0.0868
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0145	0.1169	0.0868
Echinococcus multilocularis	neuropeptide receptor A26	0.0145	0.1169	0.0868
Toxoplasma gondii	cell-cycle-associated protein kinase DYRK2, putative	0.0497	0.7416	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0145	0.1169	0.0868
Schistosoma mansoni	protein kinase	0.0115	0.0631	0.0305
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0145	0.1169	0.1169
Brugia malayi	Carboxylesterase family protein	0.0462	0.6785	0.6831
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0254	0.0254
Schistosoma mansoni	amine GPCR	0.0145	0.1169	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Brugia malayi	hypothetical protein	0.0145	0.1169	0.1145
Brugia malayi	hypothetical protein	0.0145	0.1169	0.1145
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Loa Loa (eye worm)	G-protein coupled receptor	0.0145	0.1169	0.1169
Brugia malayi	follicle stimulating hormone receptor	0.0145	0.1169	0.1145
Echinococcus granulosus	allatostatin A receptor	0.0145	0.1169	0.0868
Schistosoma mansoni	hypothetical protein	0.011	0.0545	0.0216
Leishmania major	serine/threonine kinase-like protein, putative	0.0115	0.0631	0.0802
Entamoeba histolytica	protein kinase domain containing protein	0.0497	0.7416	1
Schistosoma mansoni	biogenic amine receptor	0.0145	0.1169	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Onchocerca volvulus		0.0145	0.1169	1
Onchocerca volvulus	Putative endochitinase	0.0092	0.0214	0.1547
Brugia malayi	Serotonin receptor	0.0145	0.1169	0.1145
Echinococcus multilocularis	neuropeptide s receptor	0.0145	0.1169	0.0868
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0638	0.9915	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0145	0.1169	0.0868
Brugia malayi	sulfakinin receptor protein	0.0145	0.1169	0.1145
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0145	0.1169	0.0868
Schistosoma mansoni	hypothetical protein	0.0145	0.1169	0.0868
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0145	0.1169	0.0868
Echinococcus multilocularis	fmrfamide receptor	0.0145	0.1169	0.0868
Schistosoma mansoni	hypothetical protein	0.0145	0.1169	0.0868
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0145	0.1169	1
Onchocerca volvulus		0.0145	0.1169	1
Brugia malayi	larval opioid receptor	0.0145	0.1169	0.1145
Echinococcus granulosus	7tm_1 domain containing protein	0.0145	0.1169	0.0868
Schistosoma mansoni	serine/threonine protein kinase	0.0115	0.0631	0.0305
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0145	0.1169	0.0868
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0145	0.1169	0.0868
Echinococcus multilocularis	g-protein coupled receptor	0.0145	0.1169	0.0868
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0145	0.1169	0.0868
Loa Loa (eye worm)	hypothetical protein	0.013	0.0891	0.0891
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0115	0.0631	0.0412
Onchocerca volvulus		0.0145	0.1169	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Onchocerca volvulus		0.0145	0.1169	1
Echinococcus granulosus	orexin receptor type 2	0.0145	0.1169	0.0868
Echinococcus multilocularis	neuropeptide receptor	0.0145	0.1169	0.0868
Trichomonas vaginalis	CMGC family protein kinase	0.0497	0.7416	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0145	0.1169	0.0868
Echinococcus multilocularis	carboxylesterase 5A	0.0462	0.6785	0.6731
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0145	0.1169	1
Echinococcus granulosus	Cell division cycle 2 protein kinase	0.0115	0.0631	0.0305
Trypanosoma cruzi	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0497	0.7416	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0145	0.1169	0.0868
Schistosoma mansoni	neuropeptide receptor	0.0145	0.1169	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Echinococcus granulosus	Pfam-B_8186 domain containing protein	0.011	0.0545	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0145	0.1169	0.0868
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0145	0.1169	0.0868
Echinococcus granulosus	serine:threonine protein kinase NLK	0.0115	0.0631	0.0305
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0145	0.1169	0.0868
Schistosoma mansoni	neuropeptide receptor	0.0145	0.1169	0.0868
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0145	0.1169	0.0868
Schistosoma mansoni	myosin xvIII	0.0145	0.1169	0.0868
Echinococcus multilocularis	dual specificity	0.0497	0.7416	0.7391
Echinococcus granulosus	rhodopsin orphan GPCR	0.0145	0.1169	0.0868
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0145	0.1169	0.0868
Brugia malayi	Cell division protein kinase 2	0.0115	0.0631	0.0599
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0145	0.1169	0.0868
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0145	0.1169	0.0868
Entamoeba histolytica	cell division protein kinase 2, putative	0.0115	0.0631	0.0802
Echinococcus multilocularis	neuropeptide receptor	0.0145	0.1169	0.0868
Entamoeba histolytica	protein kinase domain containing protein	0.0115	0.0631	0.0802
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Loa Loa (eye worm)	carboxylesterase	0.0462	0.6785	0.6785
Trypanosoma brucei	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0497	0.7416	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0115	0.0631	0.0631
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0145	0.1169	0.1145
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Onchocerca volvulus		0.0145	0.1169	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0145	0.1169	0.0868
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0099	0.0339	0.0406
Echinococcus multilocularis	g protein coupled receptor	0.0145	0.1169	0.0868
Echinococcus granulosus	dro:myosuppressin receptor	0.0145	0.1169	0.0868
Schistosoma mansoni	hypothetical protein	0.0638	0.9915	1
Giardia lamblia	Kinase, CMGC DYRK	0.0497	0.7416	1
Onchocerca volvulus		0.0145	0.1169	1
Onchocerca volvulus		0.0145	0.1169	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Echinococcus multilocularis	G protein coupled receptor 139	0.0145	0.1169	0.0868
Schistosoma mansoni	opsin-like receptor	0.0145	0.1169	0.0868
Echinococcus multilocularis	cyclin dependent kinase 9	0.0115	0.0631	0.0305
Echinococcus multilocularis	fmrfamide receptor	0.0145	0.1169	0.0868
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0145	0.1169	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Onchocerca volvulus		0.0145	0.1169	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0145	0.1169	0.0868
Echinococcus multilocularis	Cell division cycle 2 protein kinase	0.0115	0.0631	0.0305
Echinococcus multilocularis	serine:threonine protein kinase NLK	0.0115	0.0631	0.0305
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0145	0.1169	0.1169
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0145	0.1169	0.0868
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0145	0.1169	0.0868
Echinococcus granulosus	neuropeptide FF receptor 2	0.0145	0.1169	0.0868
Loa Loa (eye worm)	CMGC/CDK/CRK7 protein kinase	0.0115	0.0631	0.0631
Echinococcus granulosus	rhodopsin orphan GPCR	0.0145	0.1169	0.0868
Echinococcus granulosus	rhodopsin orphan GPCR	0.0145	0.1169	0.0868
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0145	0.1169	0.0868
Trypanosoma brucei	protein kinase, putative	0.0115	0.0631	0.0412
Schistosoma mansoni	amine GPCR	0.0145	0.1169	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Schistosoma mansoni	amine GPCR	0.0145	0.1169	0.0868
Brugia malayi	Dual-specificity tyrosine-phosphorylation regulated kinase 2	0.0497	0.7416	0.747
Loa Loa (eye worm)	CMGC/DYRK/DYRK2 protein kinase	0.0497	0.7416	0.7416
Brugia malayi	hypothetical protein	0.0145	0.1169	0.1145
Schistosoma mansoni	amine GPCR	0.0145	0.1169	0.0868
Echinococcus multilocularis	serotonin receptor	0.0145	0.1169	0.0868
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0145	0.1169	0.0868
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0145	0.1169	0.1169
Echinococcus granulosus	neuropeptide Y receptor	0.0145	0.1169	0.0868
Schistosoma mansoni	neuropeptide F-like receptor	0.0145	0.1169	0.0868
Echinococcus multilocularis	acetylcholinesterase	0.0462	0.6785	0.6731
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0145	0.1169	0.0868
Echinococcus multilocularis	acetylcholinesterase	0.0462	0.6785	0.6731
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0145	0.1169	0.0868
Loa Loa (eye worm)	G-protein coupled receptor	0.0145	0.1169	0.1169
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0145	0.1169	0.0868
Brugia malayi	Endochitinase	0.0092	0.0214	0.0177
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0099	0.0339	0.0339
Echinococcus granulosus	acetylcholinesterase	0.0462	0.6785	0.6731
Echinococcus granulosus	dual specificity	0.0497	0.7416	0.7391
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0145	0.1169	0.0868
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0145	0.1169	0.0868
Entamoeba histolytica	protein kinase, putative	0.0497	0.7416	1
Schistosoma mansoni	neuropeptide receptor	0.0145	0.1169	0.0868
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0145	0.1169	0.1145
Brugia malayi	hypothetical protein	0.0145	0.1169	0.1145
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0638	0.9915	1
Echinococcus granulosus	neuropeptide s receptor	0.0145	0.1169	0.0868
Echinococcus granulosus	biogenic amine 5HT receptor	0.0145	0.1169	0.0868
Echinococcus multilocularis	neuropeptide Y receptor	0.0145	0.1169	0.0868
Brugia malayi	G-protein coupled receptor	0.0145	0.1169	0.1145
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Loa Loa (eye worm)	hypothetical protein	0.013	0.0891	0.0891
Brugia malayi	Serotonin receptor	0.0145	0.1169	0.1145
Onchocerca volvulus		0.013	0.0891	0.7538
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0638	0.9915	1
Brugia malayi	hypothetical protein	0.0145	0.1169	0.1145
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0145	0.1169	0.0868
Brugia malayi	Dopamine receptor protein 2	0.0145	0.1169	0.1145
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0145	0.1169	0.1145
Echinococcus granulosus	cyclin dependent kinase 9	0.0115	0.0631	0.0305
Brugia malayi	Hepatocellular carcinoma-associated antigen 59 family protein	0.013	0.0891	0.0863
Onchocerca volvulus		0.0145	0.1169	1
Brugia malayi	Dopamine receptor	0.0145	0.1169	0.1145
Plasmodium vivax	hypothetical protein, conserved	0.013	0.0891	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Schistosoma mansoni	neuropeptide F-like receptor	0.0145	0.1169	0.0868
Entamoeba histolytica	protein kinase domain containing protein	0.0099	0.0339	0.0406
Onchocerca volvulus		0.0145	0.1169	1
Echinococcus granulosus	g protein coupled receptor	0.0145	0.1169	0.0868
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0145	0.1169	0.1169
Echinococcus granulosus	serotonin receptor	0.0145	0.1169	0.0868
Echinococcus granulosus	neuropeptide receptor	0.0145	0.1169	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Brugia malayi	Melatonin receptor type 1A	0.0145	0.1169	0.1145
Echinococcus granulosus	neuropeptides capa receptor	0.0145	0.1169	0.0868
Onchocerca volvulus		0.013	0.0891	0.7538
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Entamoeba histolytica	protein kinase, putative	0.0099	0.0339	0.0406
Loa Loa (eye worm)	cuticular endochitinase	0.0082	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Loa Loa (eye worm)	hypothetical protein	0.0462	0.6785	0.6785
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0145	0.1169	0.0868
Echinococcus multilocularis	g protein coupled receptor	0.0145	0.1169	0.0868
Echinococcus granulosus	7TM GPCR rhodopsin	0.0145	0.1169	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0145	0.1169	0.1169
Schistosoma mansoni	hypothetical protein	0.013	0.0891	0.0577
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0145	0.1169	0.0868
Loa Loa (eye worm)	melatonin receptor type 1A	0.0145	0.1169	0.1169
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0145	0.1169	0.0868
Echinococcus multilocularis	neuropeptides capa receptor	0.0145	0.1169	0.0868
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0145	0.1169	0.0868
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0145	0.1169	0.0868
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0145	0.1169	0.0868
Loa Loa (eye worm)	neuropeptide F receptor	0.0145	0.1169	0.1169
Trichomonas vaginalis	CMGC family protein kinase	0.0497	0.7416	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Onchocerca volvulus		0.0145	0.1169	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0145	0.1169	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Echinococcus granulosus	g protein coupled receptor	0.0145	0.1169	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Echinococcus multilocularis	hypothetical protein	0.011	0.0545	0.0216
Brugia malayi	neuropeptide F receptor	0.0145	0.1169	0.1145
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0145	0.1169	0.0868
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0145	0.1169	0.0868
Echinococcus multilocularis	neuropeptides capa receptor	0.0145	0.1169	0.0868
Echinococcus granulosus	G protein coupled receptor 139	0.0145	0.1169	0.0868
Schistosoma mansoni	serine/threonine kinase	0.0115	0.0631	0.0305
Brugia malayi	AKH receptor	0.0145	0.1169	0.1145
Onchocerca volvulus		0.0145	0.1169	1
Leishmania major	mitogen-activated protein kinase, putative,map kinase-like protein	0.0115	0.0631	0.0802
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Echinococcus granulosus	dual specificity	0.0497	0.7416	0.7391
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1169	0.1169
Schistosoma mansoni	neuropeptide f receptor 76f	0.0145	0.1169	0.0868
Echinococcus multilocularis	somatostatin receptor	0.0145	0.1169	0.0868
Echinococcus multilocularis	serotonin receptor	0.0145	0.1169	0.0868
Brugia malayi	RE15519p	0.0145	0.1169	0.1145
Entamoeba histolytica	hypothetical protein	0.0099	0.0339	0.0406
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0145	0.1169	0.0868

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.5 10'-7M	Inhibition of Musca domestica (house fly) NAIDM head acetylcholinesterase	ChEMBL.	No reference
IC50 (binding)	= 9 10'-7M	Inhibition of Bos taurus (bovine) erythrocytes acetylcholinesterase	ChEMBL.	No reference
IC50 (binding)	= 5.7 nM	Inhibition of drug-susceptible Nephotettix cincticeps Ageo (green rice leafhopper) acetylcholinesterase	ChEMBL.	No reference
IC50 (binding)	= 60.5 uM	Inhibition of bovine erythrocyte acetylcholinesterase (AChE)	ChEMBL.	No reference
IC50 (binding)	= 60.5 uM	Inhibition of bovine erythrocyte acetylcholinesterase (AChE)	ChEMBL.	No reference
LD50 (functional)	> 100 mg kg-1	Insecticidal activity against blowfly Lucilia cuprina	ChEMBL.	No reference
LD50 (functional)	< 0.5 p.p.m.	Insecticidal activity against southern Corn rootworm (SCRW)	ChEMBL.	No reference
log(1/I50) (binding)	= 8.4	Inhibition of susceptible Nephotettix cincticeps Izumi (green rice leafhopper) acetylcholinesterase activity	ChEMBL.	No reference
log(1/I50) (binding)	= 9.15	Inhibition of susceptible Nephotettix cincticeps Ageo (green rice leafhopper) acetylcholinesterase activity	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL352608

Bibliographic References

No literature references available for this target.

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Detailed information for compound 285587