Detailed information for compound 319690

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 435.602 | Formula: C27H37N3O2
  • H donors: 2 H acceptors: 2 LogP: 5.84 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccc(cc1)NC(=O)C1(CCc2c(C1)cccc2)C(=O)NCCC(C)C)CC
  • InChi: 1S/C27H37N3O2/c1-5-30(6-2)24-13-11-23(12-14-24)29-26(32)27(25(31)28-18-16-20(3)4)17-15-21-9-7-8-10-22(21)19-27/h7-14,20H,5-6,15-19H2,1-4H3,(H,28,31)(H,29,32)
  • InChiKey: DXWIFVKXTXDEED-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0853 0.5154 1
Brugia malayi Cathepsin L-like precursor 0.0267 0.1589 0.1589
Schistosoma mansoni dihydrofolate reductase 0.0081 0.0453 0.0453
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0056 0.0307 0.0307
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0853 0.5154 1
Brugia malayi hypothetical protein 0.0032 0.0156 0.0156
Loa Loa (eye worm) amidase 0.0015 0.0056 0.0056
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0126 0.0732 0.0731
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0853 0.5154 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.1145 0.2177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0853 0.5154 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0107 0.0614 0.0614
Giardia lamblia Encystation-specific protease 0.0194 0.1145 0.2793
Brugia malayi orphan nuclear receptor NR2E1 0.005 0.027 0.027
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0194 0.1145 0.2135
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0176 0.1036 0.1035
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0107 0.0614 0.0613
Loa Loa (eye worm) hypothetical protein 0.0107 0.0614 0.0614
Mycobacterium tuberculosis Carboxylesterase LipT 0.0032 0.0156 0.3181
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0015 0.0056 0.0875
Brugia malayi Uncoordinated protein 44 0.0013 0.0045 0.0045
Onchocerca volvulus Cathepsin L homolog 0.0853 0.5154 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.1145 0.1145
Trypanosoma brucei DNA polymerase eta, putative 0.0014 0.0046 0.0061
Trypanosoma cruzi cysteine peptidase, putative 0.0853 0.5154 0.5147
Trypanosoma cruzi cysteine peptidase, putative 0.0853 0.5154 0.5147
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0461 0.277 0.277
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0056 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.0307
Entamoeba histolytica cysteine protease, putative 0.0461 0.277 0.5333
Echinococcus granulosus FTZ F1 alpha 0.0107 0.0614 0.0613
Plasmodium falciparum serine repeat antigen 1 0.0194 0.1145 0.2135
Trypanosoma cruzi cruzipain precursor, putative 0.0267 0.1589 0.1577
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0194 0.1145 0.2177
Leishmania major cathepsin L-like protease 0.0853 0.5154 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0461 0.277 0.5348
Leishmania major hypothetical protein, conserved 0.0015 0.0056 0.0081
Loa Loa (eye worm) hypothetical protein 0.0107 0.0614 0.0614
Schistosoma mansoni zinc finger protein 0.005 0.027 0.027
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0011 0.0029 0.0015
Trypanosoma cruzi cysteine peptidase, putative 0.0853 0.5154 0.5147
Loa Loa (eye worm) hypothetical protein 0.0107 0.0614 0.0614
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0032 0.0156 0.0196
Loa Loa (eye worm) ctsf protein 0.0853 0.5154 0.5154
Entamoeba histolytica cysteine proteinase, putative 0.0586 0.3529 0.6818
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.005 0.027 0.027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0461 0.277 0.5348
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0853 0.5154 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0029 0.014 0.0185
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0056 0.0307 0.0307
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.027 0.0523
Schistosoma mansoni hypothetical protein 0.0049 0.0261 0.026
Brugia malayi Nuclear hormone receptor-like 1 0.0107 0.0614 0.0613
Brugia malayi small heat shock protein 0.0414 0.2481 0.248
Entamoeba histolytica cysteine protease, putative 0.0194 0.1145 0.2151
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0001
Onchocerca volvulus Bile acid receptor homolog 0.0107 0.0614 0.119
Echinococcus granulosus nuclear factor of activated T cells 5 0.0069 0.0382 0.0382
Giardia lamblia Cathepsin L precursor 0.0194 0.1145 0.2793
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0056 0.0307 0.0307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0853 0.5154 1
Onchocerca volvulus 0.0194 0.1145 0.222
Entamoeba histolytica cysteine protease, putative 0.0461 0.277 0.5333
Schistosoma mansoni amidase 0.0126 0.0732 0.0731
Echinococcus multilocularis nuclear receptor nhr 48 0.005 0.027 0.027
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0107 0.0614 0.0613
Brugia malayi F/Y-rich N-terminus family protein 0.0007 0.0003 0.0003
Brugia malayi Cathepsin L-like precursor 0.0853 0.5154 0.5154
Echinococcus granulosus microtubule associated protein 2 0.0472 0.2833 0.2832
Echinococcus granulosus cathepsin l cysteine peptidase 0.0853 0.5154 0.5154
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0046 0.0045
Leishmania major protein kinase, putative 0.0013 0.0045 0.006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0197 0.0183
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.006 0.033 0.0329
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0046 0.0045
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.1145 0.1144
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0015 0.0056 0.0056
Onchocerca volvulus Netrin receptor homolog 0.0013 0.0045 0.0087
Brugia malayi nuclear hormone receptor 0.005 0.027 0.027
Entamoeba histolytica cysteine proteinase, putative 0.0853 0.5154 1
Loa Loa (eye worm) hypothetical protein 0.0586 0.3529 0.3529
Plasmodium falciparum serine repeat antigen 2 0.0194 0.1145 0.2135
Loa Loa (eye worm) hypothetical protein 0.005 0.027 0.027
Onchocerca volvulus 0.0032 0.0156 0.0302
Brugia malayi Cathepsin L-like precursor 0.0853 0.5154 0.5154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0853 0.5154 1
Echinococcus multilocularis acetylcholinesterase 0.0188 0.1104 0.1104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0853 0.5154 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0011 0.0029 0.0015
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0011 0.0031 0.0031
Echinococcus multilocularis cpg binding protein 0.0023 0.0101 0.01
Trypanosoma cruzi amidase, putative 0.0015 0.0056 0.0042
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0032 0.0156 0.3181
Onchocerca volvulus 0.0107 0.0614 0.119
Loa Loa (eye worm) histone methyltransferase 0.0007 0.0004 0.0004
Giardia lamblia Cathepsin L precursor 0.0194 0.1145 0.2793
Echinococcus granulosus single minded 2 0.0031 0.0151 0.015
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0644 0.3884 0.3883
Schistosoma mansoni DNA polymerase eta 0.0014 0.0046 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0853 0.5154 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0086 0.0489 0.0897
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0107 0.0614 0.0613
Entamoeba histolytica cysteine protease, putative 0.0461 0.277 0.5333
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0853 0.5154 0.5154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0853 0.5154 1
Onchocerca volvulus Cathepsin F homolog 0.0853 0.5154 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0156 0.0248
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0586 0.3529 0.6828
Loa Loa (eye worm) hypothetical protein 0.0267 0.1589 0.1589
Echinococcus multilocularis BC026374 protein (S09 family) 0.0032 0.0156 0.0156
Loa Loa (eye worm) amidase 0.0015 0.0056 0.0056
Echinococcus multilocularis neuroligin 0.0032 0.0156 0.0156
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0853 0.5154 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.0714 0.0714
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.1145 0.1144
Brugia malayi cathepsin L-like cysteine proteinase 0.0194 0.1145 0.1144
Plasmodium falciparum lysophospholipase, putative 0.0086 0.0489 0.0849
Giardia lamblia Cathepsin B precursor 0.0644 0.3884 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0086 0.0489 0.0868
Schistosoma mansoni nuclear hormone receptor 0.005 0.027 0.027
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0039 0.0202 0.0202
Schistosoma mansoni hypothetical protein 0.0013 0.0045 0.0045
Brugia malayi Nuclear hormone receptor E75 0.005 0.027 0.027
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0853 0.5154 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0197 0.0183
Loa Loa (eye worm) hypothetical protein 0.0188 0.1104 0.1104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0853 0.5154 1
Onchocerca volvulus 0.0032 0.0156 0.0302
Entamoeba histolytica cysteine proteinase 1, putative 0.0461 0.277 0.5333
Toxoplasma gondii cathepsin B 0.0644 0.3884 0.7534
Loa Loa (eye worm) acetyltransferase 0.0108 0.0619 0.0619
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0461 0.277 0.277
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0107 0.0614 0.0613
Giardia lamblia Cathepsin L precursor 0.0194 0.1145 0.2793
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0086 0.0489 0.0897
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0644 0.3884 0.7521
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0197 0.0183
Mycobacterium ulcerans lysophospholipase 0.0086 0.0489 1
Brugia malayi nuclear receptor NHR-88 0.0107 0.0614 0.0613
Loa Loa (eye worm) CXXC zinc finger family protein 0.0021 0.0093 0.0093
Plasmodium vivax unspecified product 0.0267 0.1589 0.3007
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.1145 0.1144
Trypanosoma brucei DNA polymerase IV, putative 0.0032 0.0159 0.0282
Loa Loa (eye worm) hypothetical protein 0.005 0.027 0.027
Echinococcus multilocularis Ankyrin 0.0014 0.0046 0.0045
Echinococcus multilocularis transfer RNA-Lys 0.0031 0.0151 0.015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0107 0.0614 0.0613
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0083 0.0134
Entamoeba histolytica cysteine protease, putative 0.0461 0.277 0.5333
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0194 0.1145 0.2135
Giardia lamblia Cathepsin B precursor 0.0194 0.1145 0.2793
Entamoeba histolytica cysteine protease, putative 0.0461 0.277 0.5333
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.165 1 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0069 0.0382 0.0382
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0079 0.0442 0.0441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0107 0.0614 0.0614
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0194 0.1145 0.2177
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0015 0.0056 0.0081
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.1145 0.1144
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0107 0.0614 0.0613
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0461 0.277 0.277
Loa Loa (eye worm) hypothetical protein 0.0194 0.1145 0.1145
Loa Loa (eye worm) hypothetical protein 0.0586 0.3529 0.3529
Schistosoma mansoni hypothetical protein 0.0116 0.0668 0.0668
Schistosoma mansoni RAR-like nuclear receptor 0.0107 0.0614 0.0613
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0107 0.0614 0.0613
Brugia malayi hypothetical protein 0.0011 0.0029 0.0029
Schistosoma mansoni single-minded 0.0042 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.005 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.0307
Brugia malayi conserved hypotetical protein 0.005 0.027 0.027
Onchocerca volvulus 0.0853 0.5154 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0194 0.1145 0.2135
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0197 0.0355
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0194 0.1145 0.2135
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0853 0.5154 1
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0031 0.0151 0.0265
Trypanosoma brucei monoglyceride lipase, putative 0.0086 0.0489 0.0923
Loa Loa (eye worm) hypothetical protein 0.005 0.027 0.027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0107 0.0614 0.0614
Echinococcus multilocularis ecdysone induced protein 78C 0.0107 0.0614 0.0613
Echinococcus granulosus dna polymerase eta 0.0014 0.0046 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.1145 0.2177
Brugia malayi Nuclear hormone receptor E75 0.005 0.027 0.027
Entamoeba histolytica cysteine protease, putative 0.0461 0.277 0.5333
Loa Loa (eye worm) hypothetical protein 0.005 0.027 0.027
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0107 0.0614 0.0613
Leishmania major cathepsin L-like protease 0.0853 0.5154 1
Echinococcus multilocularis cysteine protease 0.0853 0.5154 0.5154
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0197 0.0355
Loa Loa (eye worm) cysteine protease 0.0853 0.5154 0.5154
Echinococcus multilocularis geminin 0.0116 0.0668 0.0668
Onchocerca volvulus 0.005 0.027 0.0523
Onchocerca volvulus 0.0047 0.0251 0.0486
Plasmodium falciparum serine repeat antigen 7 0.0194 0.1145 0.2135
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0107 0.0614 0.0613
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0194 0.1145 0.1144
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.165 1 1
Echinococcus granulosus nuclear receptor nhr 48 0.005 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0059 0.0319 0.0319
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0194 0.1145 0.2793
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0107 0.0614 0.0613
Echinococcus granulosus cathepsin b 0.165 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.1145 0.2177
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0107 0.0614 0.0613
Entamoeba histolytica cysteine protease, putative 0.0853 0.5154 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0121 0.0697 0.0696
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0046 0.0046
Onchocerca volvulus 0.0853 0.5154 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0444 0.0444
Brugia malayi Carboxylesterase family protein 0.0032 0.0156 0.0156
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0046 0.0045
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0086 0.0489 0.0868
Echinococcus multilocularis cysteine protease 0.0853 0.5154 0.5154
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0032 0.0156 0.0248
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0107 0.0614 0.0613
Loa Loa (eye worm) hypothetical protein 0.005 0.027 0.027
Echinococcus multilocularis cathepsin L 0.0194 0.1145 0.1144
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0015 0.0056 0.0586
Echinococcus multilocularis thyroid hormone receptor alpha 0.0283 0.1686 0.1685
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0461 0.277 0.5361
Plasmodium vivax serine-repeat antigen (SERA) 0.0194 0.1145 0.2135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0853 0.5154 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0039 0.0202 0.4119
Trypanosoma cruzi cysteine peptidase, putative 0.0267 0.1589 0.1577
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0267 0.1589 0.1589
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0197 0.3841
Giardia lamblia Cysteine protease 0.0194 0.1145 0.2793
Plasmodium falciparum serine repeat antigen 3 0.0194 0.1145 0.2135
Schistosoma mansoni gliotactin 0.0032 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0032 0.0156 0.0156
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0107 0.0614 0.0613
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0107 0.0614 0.0614
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0107 0.0614 0.119
Trypanosoma cruzi monoglyceride lipase, putative 0.0086 0.0489 0.0475
Giardia lamblia Cathepsin B precursor 0.0194 0.1145 0.2793
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.1145 0.1144
Loa Loa (eye worm) hypothetical protein 0.0011 0.0029 0.0029
Onchocerca volvulus 0.0032 0.0156 0.0302
Giardia lamblia Cathepsin L precursor 0.0194 0.1145 0.2793
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0032 0.0156 0.0248
Loa Loa (eye worm) DIX domain-containing protein 0.0006 0.0001 0.0001
Schistosoma mansoni jun-related protein 0.0049 0.0261 0.026
Plasmodium falciparum serine repeat antigen 5 0.0194 0.1145 0.2135
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.1145 0.2177
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0107 0.0614 0.0613
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0194 0.1145 0.1145
Echinococcus multilocularis microtubule associated protein 2 0.0472 0.2833 0.2832
Loa Loa (eye worm) hypothetical protein 0.0414 0.2481 0.2481
Trypanosoma cruzi amidase, putative 0.0015 0.0056 0.0042
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0031 0.0151 0.0186
Schistosoma mansoni fatty-acid amide hydrolase 0.0015 0.0056 0.0056
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0081 0.0453 0.9245
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.005 0.027 0.027
Onchocerca volvulus 0.0021 0.0093 0.018
Loa Loa (eye worm) hypothetical protein 0.0126 0.0732 0.0732
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0194 0.1145 0.2177
Mycobacterium ulcerans peptide amidase, GatA 0.0015 0.0056 0.0875
Brugia malayi photoreceptor-specific nuclear receptor 0.0107 0.0614 0.0613
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0032 0.0156 0.0156
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.165 1 1
Schistosoma mansoni nuclear receptor 0.005 0.027 0.027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0853 0.5154 1
Trypanosoma brucei unspecified product 0.0009 0.002 0.0011
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0015 0.0056 0.0056
Entamoeba histolytica hypothetical protein 0.0194 0.1145 0.2151
Mycobacterium tuberculosis Possible lysophospholipase 0.0086 0.0489 1
Plasmodium falciparum serine repeat antigen 4 0.0194 0.1145 0.2135
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0108 0.0619 0.0618
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0853 0.5154 0.5154
Loa Loa (eye worm) dihydrofolate reductase 0.0081 0.0453 0.0453
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0015 0.0015
Loa Loa (eye worm) nuclear receptor NHR-67 0.005 0.027 0.027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0853 0.5154 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0105 0.06 0.06
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0197 0.0355
Giardia lamblia Cathepsin B precursor 0.0194 0.1145 0.2793
Plasmodium falciparum lysophospholipase, putative 0.0086 0.0489 0.0849
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0853 0.5154 0.5154
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.027 0.027
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0307 0.0307
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0037 0.0186 0.0186
Leishmania major cathepsin L-like protease 0.0853 0.5154 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0046
Loa Loa (eye worm) nuclear receptor nhr-7B 0.005 0.027 0.027
Giardia lamblia Cathepsin B precursor 0.0194 0.1145 0.2793
Entamoeba histolytica cysteine protease, putative 0.0461 0.277 0.5333
Brugia malayi Cathepsin L-like cysteine proteinase 0.0586 0.3529 0.3528
Brugia malayi nuclear receptor NHR-88 0.005 0.027 0.027
Echinococcus multilocularis cathepsin b 0.165 1 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0614 0.0614
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0197 0.0355
Loa Loa (eye worm) hypothetical protein 0.0267 0.1589 0.1589
Entamoeba histolytica cysteine protease, putative 0.0461 0.277 0.5333
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0015 0.0056 0.0586
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0853 0.5154 1
Leishmania major monoglyceride lipase, putative 0.0086 0.0489 0.0923
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0107 0.0614 0.0613
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0107 0.0614 0.0614
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0032 0.0156 0.0156
Echinococcus multilocularis carboxylesterase 5A 0.0188 0.1104 0.1104
Mycobacterium ulcerans amidase 0.0015 0.0056 0.0875
Toxoplasma gondii histone lysine methyltransferase SET1 0.0043 0.0226 0.0437
Brugia malayi Protein kinase domain containing protein 0.0013 0.0045 0.0045
Giardia lamblia Cathepsin B precursor 0.0644 0.3884 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0011 0.0029 0.0015
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0194 0.1145 0.2135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0853 0.5154 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.0307
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0194 0.1145 0.2177
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0586 0.3529 0.3519
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0086 0.0489 0.0897
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0004 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.1145 0.2177
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0058 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0107 0.0614 0.0614
Mycobacterium tuberculosis Conserved hypothetical protein 0.0014 0.0046 0.0917
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0015 0.0056 0.113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0461 0.277 0.5361
Schistosoma mansoni cathepsin F (C01 family) 0.0853 0.5154 0.5154
Loa Loa (eye worm) steroid hormone receptor 0.0107 0.0614 0.0614
Echinococcus granulosus cathepsin L cysteine proteinase 0.0853 0.5154 0.5154
Brugia malayi Papain family cysteine protease containing protein 0.0461 0.277 0.277
Onchocerca volvulus 0.0032 0.0156 0.0302
Trichomonas vaginalis spcc417.12 protein, putative 0.0032 0.0156 0.0248
Echinococcus granulosus neuroligin 0.0032 0.0156 0.0156
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0853 0.5154 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0107 0.0614 0.0613
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0032 0.0156 0.0302
Brugia malayi Papain family cysteine protease containing protein 0.0461 0.277 0.277
Echinococcus granulosus jun protein 0.006 0.033 0.0329
Onchocerca volvulus 0.005 0.027 0.0523
Brugia malayi CXXC zinc finger family protein 0.0021 0.0093 0.0093
Schistosoma mansoni ankyrin 23/unc44 0.0013 0.0045 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0489 0.0897
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0015 0.0056 0.113
Loa Loa (eye worm) DR-78 0.005 0.027 0.027
Trypanosoma brucei cysteine peptidase C (CPC) 0.0644 0.3884 0.7528
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0194 0.1145 0.1144
Leishmania major cathepsin L-like protease 0.0853 0.5154 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0031 0.0151 0.0136
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0083 0.0134
Entamoeba histolytica cysteine protease, putative 0.0194 0.1145 0.2151
Schistosoma mansoni cathepsin S (C01 family) 0.0194 0.1145 0.1144
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.1145 0.2177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0853 0.5154 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0032 0.0156 0.0156
Trypanosoma cruzi DNA polymerase eta, putative 0.0014 0.0046 0.0031
Echinococcus multilocularis cathepsin L 0.0461 0.277 0.277
Echinococcus granulosus cathepsin b 0.165 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0853 0.5154 1
Echinococcus multilocularis dna polymerase eta 0.0014 0.0046 0.0045
Brugia malayi cathepsin F-like cysteine proteinase 0.0194 0.1145 0.1144
Echinococcus granulosus cpg binding protein 0.0023 0.0101 0.01
Trypanosoma cruzi cysteine protease, putative 0.0461 0.277 0.276
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0086 0.0489 0.0897
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0011 0.0029 0.0028
Giardia lamblia Cysteine protease 0.0194 0.1145 0.2793
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0194 0.1145 0.2135
Echinococcus granulosus BC026374 protein S09 family 0.0032 0.0156 0.0156
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.005 0.027 0.027
Echinococcus granulosus fatty acid amide hydrolase 1 0.0015 0.0056 0.0056
Onchocerca volvulus 0.0089 0.0507 0.0984
Echinococcus granulosus cathepsin L 0.0461 0.277 0.277
Schistosoma mansoni microtubule-associated protein tau 0.0472 0.2833 0.2832
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0107 0.0614 0.0613
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0197 0.0355
Plasmodium vivax vivapain-1 0.0461 0.277 0.5324
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0056 0.0307 0.0307
Entamoeba histolytica cysteine protease, putative 0.0194 0.1145 0.2151
Brugia malayi amidase 0.0126 0.0732 0.0731
Entamoeba histolytica cysteine proteinase 2 0.0461 0.277 0.5333
Echinococcus granulosus cathepsin l1 0.0586 0.3529 0.3528
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0853 0.5154 0.5154
Giardia lamblia Cathepsin L precursor 0.0194 0.1145 0.2793
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0031 0.0151 0.0292
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0039 0.0202 0.0202
Trypanosoma brucei unspecified product 0.0009 0.002 0.0011
Echinococcus granulosus fatty acid amide hydrolase 1 0.0126 0.0732 0.0731
Loa Loa (eye worm) hypothetical protein 0.005 0.027 0.027
Echinococcus granulosus dihydrofolate reductase 0.0081 0.0453 0.0453
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0011 0.0029 0.0015
Loa Loa (eye worm) acetylcholinesterase 1 0.0188 0.1104 0.1104
Echinococcus multilocularis dihydrofolate reductase 0.0081 0.0453 0.0453
Echinococcus granulosus cysteine protease 0.0461 0.277 0.277
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0194 0.1145 0.2135
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0039 0.0202 0.3949
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0853 0.5154 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0013 0.0045 0.0045
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0197 0.3841
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0107 0.0614 0.0613
Loa Loa (eye worm) CYP4Cod1 0.0008 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0089 0.0507 0.0507
Brugia malayi steroid hormone receptor 0.0107 0.0614 0.0613
Schistosoma mansoni thyroid hormone receptor 0.0283 0.1686 0.1685
Loa Loa (eye worm) hypothetical protein 0.0194 0.1145 0.1145
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0194 0.1145 0.2135
Loa Loa (eye worm) hypothetical protein 0.0032 0.0156 0.0156
Loa Loa (eye worm) fibroinase 0.0853 0.5154 0.5154
Echinococcus granulosus netrin receptor unc 5 0.0013 0.0045 0.0045
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0107 0.0614 0.0613
Plasmodium vivax vivapain-2 0.0853 0.5154 1
Entamoeba histolytica cysteine protease, putative 0.0461 0.277 0.5333
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0045 0.0239 0.0238
Plasmodium falciparum lysophospholipase, putative 0.0086 0.0489 0.0849
Plasmodium falciparum cysteine proteinase falcipain 3 0.0853 0.5154 1
Giardia lamblia Cysteine protease 0.0194 0.1145 0.2793
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0107 0.0614 0.0613
Leishmania major cathepsin L-like protease 0.0853 0.5154 1
Echinococcus granulosus carboxylesterase 5A 0.0188 0.1104 0.1104
Schistosoma mansoni neuroligin 3 (S09 family) 0.0032 0.0156 0.0156
Mycobacterium ulcerans amidase 0.0015 0.0056 0.0875
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0194 0.1145 0.1144
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0015 0.0056 0.0056
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0853 0.5154 1
Brugia malayi Cytochrome P450 family protein 0.0008 0.0015 0.0014
Brugia malayi N-terminal motif family protein 0.0123 0.0714 0.0714
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0015 0.0056 0.0635
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0176 0.1036 0.1035
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.014 0.0244
Leishmania major cathepsin L-like protease 0.0853 0.5154 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0194 0.1145 0.2793
Plasmodium falciparum cysteine proteinase falcipain 1 0.0461 0.277 0.5324
Entamoeba histolytica cysteine protease, putative 0.0194 0.1145 0.2151
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.027 0.0523
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0267 0.1589 0.1589
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0197 0.0327
Onchocerca volvulus Cathepsin L homolog 0.0853 0.5154 1
Plasmodium vivax vivapain-2 0.0853 0.5154 1
Loa Loa (eye worm) nuclear hormone receptor 0.005 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0586 0.3529 0.3529
Schistosoma mansoni steroid hormone receptor ad4bp 0.0107 0.0614 0.0613
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0126 0.0732 0.0731
Echinococcus multilocularis acetylcholinesterase 0.0188 0.1104 0.1104
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0107 0.0614 0.0613
Echinococcus granulosus fatty acid amide hydrolase 1 0.0126 0.0732 0.0731
Loa Loa (eye worm) hypothetical protein 0.0107 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0032 0.0156 0.0156
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0015 0.0056 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0107 0.0614 0.0613
Onchocerca volvulus 0.0853 0.5154 1
Loa Loa (eye worm) hypothetical protein 0.005 0.027 0.027
Schistosoma mansoni netrin receptor unc5 0.0013 0.0045 0.0045
Leishmania major DNA polymerase kappa, putative 0.002 0.0083 0.0134
Schistosoma mansoni cathepsin B (C01 family) 0.0194 0.1145 0.1144
Giardia lamblia Hypothetical protein 0.0194 0.1145 0.2793
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.027 0.027
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0081 0.0453 0.9221
Schistosoma mansoni hypothetical protein 0.0116 0.0668 0.0668
Entamoeba histolytica cysteine protease, putative 0.0461 0.277 0.5333
Schistosoma mansoni nuclear hormone receptor 0.0107 0.0614 0.0613
Loa Loa (eye worm) carboxylesterase 0.0032 0.0156 0.0156
Brugia malayi bHLH-PAS transcription factor 0.0031 0.0151 0.015
Loa Loa (eye worm) hypothetical protein 0.165 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0461 0.277 0.276
Trypanosoma brucei unspecified product 0.0032 0.0159 0.0282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.1145 0.2177
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0086 0.0489 1
Onchocerca volvulus 0.0853 0.5154 1
Brugia malayi Dihydrofolate reductase 0.0081 0.0453 0.0453
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0853 0.5154 1
Schistosoma mansoni hypothetical protein 0.0304 0.1812 0.1812
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0644 0.3884 0.7528
Entamoeba histolytica cysteine protease, putative 0.0461 0.277 0.5333
Loa Loa (eye worm) carboxylesterase 0.0032 0.0156 0.0156
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0032 0.0156 0.0302
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0107 0.0614 0.0613
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0011 0.0031 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0853 0.5154 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.027 0.027
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0194 0.1145 0.2135
Schistosoma mansoni BC026374 protein (S09 family) 0.0032 0.0156 0.0156
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0013 0.0045 0.0045
Brugia malayi polk-prov protein 0.0029 0.014 0.014
Brugia malayi tailless protein 0.005 0.027 0.027
Brugia malayi Carboxylesterase family protein 0.0032 0.0156 0.0156
Brugia malayi dihydrofolate reductase family protein 0.0081 0.0453 0.0453
Brugia malayi Carboxylesterase family protein 0.0188 0.1104 0.1104
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0194 0.1145 0.2177
Echinococcus granulosus cathepsin L cysteine protease 0.0461 0.277 0.277
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0853 0.5154 1
Loa Loa (eye worm) hypothetical protein 0.005 0.027 0.027
Plasmodium vivax vivapain-3 0.0461 0.277 0.5324
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0015 0.0015
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0194 0.1145 0.2793
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0011 0.0029 0.0015
Entamoeba histolytica cysteine proteinase, putative 0.0853 0.5154 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0006 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0853 0.5154 0.5154
Leishmania major cathepsin L-like protease 0.0853 0.5154 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0118 0.068 0.068
Echinococcus granulosus para nitrobenzyl esterase 0.0032 0.0156 0.0156
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0086 0.0489 0.0897
Echinococcus multilocularis cathepsin L cysteine protease 0.0853 0.5154 0.5154
Loa Loa (eye worm) hypothetical protein 0.0267 0.1589 0.1589
Brugia malayi Carboxylesterase family protein 0.0032 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.014
Echinococcus granulosus cathepsin L 0.0194 0.1145 0.1144
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0015 0.0056 0.113
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.165 1 1
Plasmodium vivax PST-A protein 0.0086 0.0489 0.0849
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.1145 0.2177
Onchocerca volvulus Cathepsin L homolog 0.0194 0.1145 0.222
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0853 0.5154 1
Brugia malayi Cathepsin L-like precursor 0.0853 0.5154 0.5154
Toxoplasma gondii preprocathepsin c precursor, putative 0.0194 0.1145 0.222
Echinococcus granulosus acetylcholinesterase 0.0188 0.1104 0.1104
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0107 0.0614 0.0613
Brugia malayi nuclear receptor RXR 0.0056 0.0307 0.0307
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0194 0.1145 0.1144
Schistosoma mansoni fatty-acid amide hydrolase 0.0126 0.0732 0.0731
Echinococcus granulosus Ankyrin 0.0014 0.0046 0.0045
Loa Loa (eye worm) hypothetical protein 0.0194 0.1145 0.1145
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0194 0.1145 0.2135
Entamoeba histolytica cysteine protease, putative 0.0194 0.1145 0.2151
Brugia malayi nuclear hormone receptor 0.0107 0.0614 0.0613
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0039 0.0202 0.3949
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0853 0.5154 1
Toxoplasma gondii cathepsin CPC1 0.0194 0.1145 0.222
Giardia lamblia Cathepsin L-like protease 0.0194 0.1145 0.2793
Toxoplasma gondii cathepsin CPC2 0.0194 0.1145 0.222
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0194 0.1145 0.2177
Onchocerca volvulus 0.0853 0.5154 1
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0015 0.0056 0.113
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.027 0.027
Brugia malayi ecdysteroid receptor 0.0107 0.0614 0.0613
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0108 0.0619 0.0618
Trypanosoma cruzi cysteine proteinase, putative 0.0461 0.277 0.276
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.014 0.0244
Schistosoma mansoni cpg binding protein 0.0023 0.0101 0.01
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0194 0.1145 0.2135
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0194 0.1145 0.2793
Giardia lamblia Cysteine protease 0.0194 0.1145 0.2793
Echinococcus multilocularis cathepsin L cysteine protease 0.0853 0.5154 0.5154
Entamoeba histolytica cysteine protease, putative 0.0194 0.1145 0.2151
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0015 0.0056 0.113
Brugia malayi Papain family cysteine protease containing protein 0.0853 0.5154 0.5154
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0058 0.0084
Giardia lamblia Cathepsin L-like protease 0.0194 0.1145 0.2793
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0011 0.0029 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0058 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0197 0.0355
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0197 0.0183
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0194 0.1145 0.2151
Mycobacterium ulcerans putative regulatory protein 0.0031 0.0151 0.2866
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0039 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0194 0.1145 0.1145
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0032 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0194 0.1145 0.1145
Brugia malayi nuclear receptor NHR-67 0.005 0.027 0.027
Trypanosoma cruzi major cysteine proteinase, putative 0.0194 0.1145 0.1132
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0039 0.0202 0.0365
Leishmania major cysteine peptidase A (CPA) 0.0853 0.5154 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0156 0.0156
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0194 0.1145 0.2177
Entamoeba histolytica cysteine proteinase, putative 0.0461 0.277 0.5333
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0194 0.1145 0.1145
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0853 0.5154 1
Leishmania major cathepsin L-like protease 0.0853 0.5154 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.0307
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0644 0.3884 0.3874
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.165 1 1
Loa Loa (eye worm) hypothetical protein 0.0188 0.1104 0.1104
Echinococcus granulosus geminin 0.0116 0.0668 0.0668
Loa Loa (eye worm) hypothetical protein 0.005 0.027 0.027
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0197 0.0355
Brugia malayi Cathepsin L-like precursor 0.0853 0.5154 0.5154
Mycobacterium ulcerans carboxylesterase, LipT 0.0032 0.0156 0.2985
Plasmodium falciparum serine repeat antigen 8 0.0194 0.1145 0.2135
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0107 0.0614 0.0613
Plasmodium vivax serine-repeat antigen (SERA) 0.0194 0.1145 0.2135
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0197 0.0196
Brugia malayi cathepsin Z-like cysteine proteinase 0.0194 0.1145 0.1144
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0853 0.5154 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.027 0.027
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0107 0.0614 0.0613
Brugia malayi Cathepsin L-like precursor 0.0853 0.5154 0.5154
Trypanosoma cruzi cruzipain precursor, putative 0.0853 0.5154 0.5147
Plasmodium falciparum esterase, putative 0.0086 0.0489 0.0849
Echinococcus granulosus thyroid hormone receptor alpha 0.005 0.027 0.027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0107 0.0614 0.0613
Brugia malayi Cathepsin L-like precursor 0.0586 0.3529 0.3528
Entamoeba histolytica cysteine proteinase, putative 0.0461 0.277 0.5333
Brugia malayi Carboxylesterase family protein 0.0188 0.1104 0.1104
Schistosoma mansoni nuclear receptor nhr-48 0.005 0.027 0.027
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0046 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0853 0.5154 1
Onchocerca volvulus 0.0031 0.0153 0.0296
Schistosoma mansoni retinoic acid receptor RXR 0.0174 0.1024 0.1023
Brugia malayi putative amidase 0.0015 0.0056 0.0056
Plasmodium vivax unspecified product 0.0194 0.1145 0.2135
Brugia malayi nuclear receptor RXR 0.005 0.027 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0197 0.0355
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0001
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.001 0.0027 0.0051
Echinococcus multilocularis para nitrobenzyl esterase 0.0032 0.0156 0.0156
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0046 0.0045
Trypanosoma cruzi major cysteine proteinase, putative 0.0194 0.1145 0.1132
Echinococcus multilocularis jun protein 0.006 0.033 0.0329
Giardia lamblia Hypothetical protein 0.0194 0.1145 0.2793
Schistosoma mansoni cpg binding protein 0.0021 0.0093 0.0093
Brugia malayi hypothetical protein 0.0047 0.0251 0.025
Brugia malayi Cathepsin L-like precursor 0.0853 0.5154 0.5154
Loa Loa (eye worm) hypothetical protein 0.0032 0.0156 0.0156
Schistosoma mansoni hypothetical protein 0.0176 0.1036 0.1035
Schistosoma mansoni cathepsin s 0.0267 0.1589 0.1589
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0083 0.1685
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0107 0.0614 0.0613
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0086 0.0489 0.0897
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.006 0.033 0.0329
Brugia malayi nuclear hormone receptor family member odr-7 0.005 0.027 0.027
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0031 0.0151 0.0186
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0107 0.0614 0.0613
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.1145 0.2177
Brugia malayi Amidase family protein 0.0015 0.0056 0.0056
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0031 0.0151 0.0265
Brugia malayi Cytochrome P450 family protein 0.0008 0.0015 0.0014
Mycobacterium ulcerans hypothetical protein 0.0086 0.0489 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0001
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0032 0.0156 0.3181
Brugia malayi acetyltransferase, GNAT family protein 0.0108 0.0619 0.0618
Echinococcus granulosus death domain containing protein 0.0013 0.0045 0.0045
Schistosoma mansoni nuclear receptor 0.005 0.027 0.027
Giardia lamblia Cathepsin B precursor 0.0194 0.1145 0.2793
Brugia malayi cathepsin L-like precursor 0.0586 0.3529 0.3528
Brugia malayi PAS domain containing protein 0.0042 0.0216 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.1145 0.2177
Mycobacterium ulcerans amidase 0.0015 0.0056 0.0875
Echinococcus granulosus dnaJ subfamily B 0.0304 0.1812 0.1812
Onchocerca volvulus 0.0853 0.5154 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.1145 0.2177
Loa Loa (eye worm) hypothetical protein 0.0032 0.0156 0.0156
Onchocerca volvulus 0.0032 0.0156 0.0302
Echinococcus multilocularis aryl hydrocarbon receptor 0.009 0.051 0.0509
Schistosoma mansoni coup transcription factor 0.0107 0.0614 0.0613
Brugia malayi hypothetical protein 0.0056 0.0307 0.0307
Echinococcus granulosus acetylcholinesterase 0.0188 0.1104 0.1104
Schistosoma mansoni nuclear hormone receptor 0.005 0.027 0.027
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0015 0.0056 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0107 0.0614 0.0613
Trypanosoma cruzi cysteine proteinase, putative 0.0461 0.277 0.276
Schistosoma mansoni thyroid hormone receptor 0.0283 0.1686 0.1685
Loa Loa (eye worm) hypothetical protein 0.0107 0.0614 0.0614
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.1145 0.1144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0853 0.5154 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0194 0.1145 0.1144
Loa Loa (eye worm) hypothetical protein 0.0079 0.0442 0.0442
Brugia malayi cathepsin Z-like cysteine proteinase 0.0194 0.1145 0.1144
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0045 0.0045
Echinococcus granulosus cathepsin l1 0.0853 0.5154 0.5154
Entamoeba histolytica cysteine proteinase, putative 0.0461 0.277 0.5333
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0004 0.0003
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0032 0.0156 0.0156
Brugia malayi Steroid receptor seven-up type 2 0.0107 0.0614 0.0613
Loa Loa (eye worm) carboxylesterase 0.0188 0.1104 0.1104
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0123 0.0714 0.1385
Schistosoma mansoni cathepsin C 0.0194 0.1145 0.1144
Loa Loa (eye worm) hypothetical protein 0.0107 0.0614 0.0614
Brugia malayi cathepsin L precursor 0.0194 0.1145 0.1144
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0011 0.0031 0.0031
Echinococcus granulosus dna polymerase kappa 0.0038 0.0197 0.0196
Onchocerca volvulus Protein ultraspiracle homolog 0.0107 0.0614 0.119
Mycobacterium ulcerans amidase 0.0015 0.0056 0.0875
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0194 0.1145 0.1145
Giardia lamblia Cathepsin B precursor 0.0644 0.3884 1
Echinococcus multilocularis dnaJ subfamily B 0.0304 0.1812 0.1812
Brugia malayi Amidase family protein 0.0015 0.0056 0.0056
Brugia malayi hypothetical protein 0.0056 0.0307 0.0307
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.005 0.027 0.027
Echinococcus granulosus ecdysone induced protein 78C 0.0107 0.0614 0.0613
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.1145 0.1144
Schistosoma mansoni cathepsin F (C01 family) 0.0586 0.3529 0.3528
Plasmodium falciparum serine repeat antigen 9 0.0194 0.1145 0.2135
Brugia malayi hypothetical protein 0.005 0.027 0.027
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0194 0.1145 0.2151
Brugia malayi bZIP transcription factor family protein 0.006 0.033 0.0329
Entamoeba histolytica cysteine proteinase, putative 0.0461 0.277 0.5333
Brugia malayi Carboxylesterase family protein 0.0032 0.0156 0.0156
Plasmodium vivax unspecified product 0.0461 0.277 0.5324
Brugia malayi hypothetical protein 0.005 0.027 0.027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0107 0.0614 0.0614
Trypanosoma brucei monoglyceride lipase, putative 0.0086 0.0489 0.0923
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.0307
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0188 0.1104 0.1104
Brugia malayi nuclear hormone receptor family member nhr-6 0.005 0.027 0.027
Onchocerca volvulus 0.0586 0.3529 0.6846
Loa Loa (eye worm) hypothetical protein 0.0107 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0032 0.0156 0.0156
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0081 0.0453 0.9266
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.1145 0.1144
Leishmania major DNA polymerase eta, putative 0.0014 0.0046 0.0061
Schistosoma mansoni cathepsin F (C01 family) 0.0853 0.5154 0.5154
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0194 0.1145 0.2135
Schistosoma mansoni cpg binding protein 0.0023 0.0101 0.01
Plasmodium falciparum histone acetyltransferase GCN5 0.0029 0.014 0.0165
Echinococcus granulosus aryl hydrocarbon receptor 0.009 0.051 0.0509
Brugia malayi fibroinase precursor 0.0194 0.1145 0.1144
Schistosoma mansoni acetylcholinesterase 0.0032 0.0156 0.0156
Echinococcus multilocularis cathepsin b 0.165 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0489 0.0897
Onchocerca volvulus 0.0853 0.5154 1
Mycobacterium ulcerans amidase 0.0015 0.0056 0.0875
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0194 0.1145 0.2135
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0046 0.0045
Toxoplasma gondii cathepsin CPL 0.0853 0.5154 1
Brugia malayi ecdysone receptor 0.005 0.027 0.027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.1145 0.2177
Chlamydia trachomatis dihydrofolate reductase 0.0081 0.0453 1
Plasmodium falciparum serine repeat antigen 6 0.0194 0.1145 0.2135
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0197 0.0327
Echinococcus multilocularis netrin receptor unc 5 0.0013 0.0045 0.0045
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0197 0.0355
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0046 0.0045
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.005 0.027 0.027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0586 0.3529 0.6828
Loa Loa (eye worm) hypothetical protein 0.005 0.027 0.027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0853 0.5154 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0267 0.1589 0.1589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0853 0.5154 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0461 0.277 0.276
Entamoeba histolytica cysteine protease, putative 0.0461 0.277 0.5333
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0197 0.0355
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0015 0.0056 0.0056
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0013 0.0045 0.0045
Giardia lamblia Histone acetyltransferase GCN5 0.0029 0.014 0.015
Giardia lamblia Cathepsin L precursor 0.0194 0.1145 0.2793
Trypanosoma cruzi cysteine peptidase, putative 0.0853 0.5154 0.5147
Loa Loa (eye worm) cathepsin B 0.0644 0.3884 0.3884
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0174 0.1024 0.1023
Leishmania major protein kinase, putative 0.0011 0.0029 0.0028
Brugia malayi Cathepsin L-like precursor 0.0586 0.3529 0.3528
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0032 0.0156 0.0156
Echinococcus multilocularis FTZ F1 alpha 0.0107 0.0614 0.0613
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0107 0.0614 0.0613
Loa Loa (eye worm) hypothetical protein 0.005 0.027 0.027
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0039 0.0202 0.0202
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0197 0.0355
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0307 0.0307
Brugia malayi Death domain containing protein 0.0013 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.005 0.027 0.027
Entamoeba histolytica cysteine protease, putative 0.0461 0.277 0.5333
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0853 0.5154 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0853 0.5154 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.027 0.027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0853 0.5154 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) 0 uM Inhibitory concentration was measured against growth hormone secretagogue receptor using cellular function assay with fluorescent calcium indicator; ND=not determined ChEMBL. 15780615
IC50 (binding) = 2.7 uM Inhibitory concentration was measured against growth hormone secretagogue receptor ChEMBL. 15780615

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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