Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % | |
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0266 | 0.0256 | 0.0256 |
Echinococcus granulosus | carboxylesterase 5A | 0.1573 | 0.2598 | 0.2598 |
Brugia malayi | Carboxylesterase family protein | 0.0266 | 0.0256 | 0.0984 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1573 | 0.2598 | 0.2598 |
Brugia malayi | Carboxylesterase family protein | 0.1573 | 0.2598 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0266 | 0.0256 | 0.0256 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0266 | 0.0256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.5704 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1573 | 0.2598 | 0.2598 |
Onchocerca volvulus | 0.0266 | 0.0256 | 0.5 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0266 | 0.0256 | 0.0256 |
Brugia malayi | Carboxylesterase family protein | 0.0266 | 0.0256 | 0.0984 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.5704 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1573 | 0.2598 | 0.2598 |
Onchocerca volvulus | 0.0266 | 0.0256 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0256 | 0.0256 |
Schistosoma mansoni | acetylcholinesterase | 0.0266 | 0.0256 | 0.0256 |
Brugia malayi | hypothetical protein | 0.0266 | 0.0256 | 0.0984 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0266 | 0.0256 | 0.0256 |
Onchocerca volvulus | 0.0266 | 0.0256 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0256 | 0.0256 |
Echinococcus multilocularis | acetylcholinesterase | 0.1573 | 0.2598 | 0.2598 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0256 | 0.0256 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1573 | 0.2598 | 0.2598 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0266 | 0.0256 | 0.0256 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0256 | 0.0256 |
Onchocerca volvulus | 0.0266 | 0.0256 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0266 | 0.0256 | 0.0256 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0266 | 0.0256 | 0.0256 |
Schistosoma mansoni | gliotactin | 0.0266 | 0.0256 | 0.0256 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0266 | 0.0256 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1573 | 0.2598 | 0.2598 |
Loa Loa (eye worm) | carboxylesterase | 0.0266 | 0.0256 | 0.0256 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0266 | 0.0256 | 0.0256 |
Loa Loa (eye worm) | carboxylesterase | 0.0266 | 0.0256 | 0.0256 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0266 | 0.0256 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0266 | 0.0256 | 0.0256 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1573 | 0.2598 | 0.2598 |
Echinococcus granulosus | acetylcholinesterase | 0.1573 | 0.2598 | 0.2598 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0266 | 0.0256 | 0.0256 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.5704 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0256 | 0.0256 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0266 | 0.0256 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1573 | 0.2598 | 0.2598 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0266 | 0.0256 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0266 | 0.0256 | 0.0256 |
Echinococcus granulosus | neuroligin | 0.0266 | 0.0256 | 0.0256 |
Brugia malayi | Carboxylesterase family protein | 0.0266 | 0.0256 | 0.0984 |
Echinococcus multilocularis | hormone sensitive lipase | 0.5704 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0266 | 0.0256 | 0.0256 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0266 | 0.0256 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1573 | 0.2598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0256 | 0.0256 |
Brugia malayi | Carboxylesterase family protein | 0.0266 | 0.0256 | 0.0984 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.5704 | 1 | 1 |
Onchocerca volvulus | 0.0266 | 0.0256 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1573 | 0.2598 | 0.2598 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.0256 | 0.0256 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 145.7 nM | Inhibition of [3H]-anandamide binding to fatty acid amide hydrolase of rat brain membranes | ChEMBL. | 15456244 |
IC50 (binding) | = 145.7 nM | Inhibition of [3H]-anandamide binding to fatty acid amide hydrolase of rat brain membranes | ChEMBL. | 15456244 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.