TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 890.127 | Formula: C56H59N9O2
H donors: 4 H acceptors: 4 LogP: 11.92 Rotable bonds: 25
Rule of 5 violations (Lipinski): 2
SMILES: C(CCN(c1cc(OCCCNc2ccnc3c2cccc3)cc(c1)OCCCNc1ccnc2c1cccc2)CCCNc1ccnc2c1cccc2)CCNc1ccnc2c1cccc2
InChi: 1S/C56H59N9O2/c1(10-27-57-53-23-31-61-49-19-6-2-15-45(49)53)11-35-65(36-12-28-58-54-24-32-62-50-20-7-3-16-46(50)54)42-39-43(66-37-13-29-59-55-25-33-63-51-21-8-4-17-47(51)55)41-44(40-42)67-38-14-30-60-56-26-34-64-52-22-9-5-18-48(52)56/h2-9,15-26,31-34,39-41H,1,10-14,27-30,35-38H2,(H,57,61)(H,58,62)(H,59,63)(H,60,64)
InChiKey: CNXKHPWAPNKTFH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Small conductance calcium-activated potassium channel protein 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	small conductance calcium activated potassium	Get druggable targets OG5_130097	All targets in OG5_130097
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	ko:K01047 phospholipase A2 [EC3.1.1.4], putative	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	Small conductance calcium-activated potassium channel protein, putative	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	Small conductance calcium-activated potassium channel protein, putative	Get druggable targets OG5_130097	All targets in OG5_130097
Echinococcus granulosus	small conductance calcium activated potassium	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	ko:K04942 potassium intermediate/small conductance calcium-activated channel,, putative	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma mansoni	calcium-activated potassium channel	Get druggable targets OG5_130097	All targets in OG5_130097
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	expressed protein	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	IPR011996,SK channel region,domain-containing	Get druggable targets OG5_130097	All targets in OG5_130097

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	DNA repair protein RAD51	0.0024	0.0038	0.0038
Echinococcus granulosus	ribonucleoside diphosphate reductase large	0.1702	1	1
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0028	0.0063	0.0063
Mycobacterium leprae	conserved hypothetical protein	0.0211	0.1151	0.1276
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0007	0.0007
Leishmania major	hypothetical protein, conserved	0.0035	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0019	0.0007	0.0007
Echinococcus granulosus	serotonin receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0007	0.0007
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0019	0.0007	0.0007
Echinococcus granulosus	neuropeptide s receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	opsin-like receptor	0.0019	0.0007	0.0007
Echinococcus granulosus	Ankyrin	0.0028	0.0063	0.0063
Echinococcus granulosus	small conductance calcium activated potassium	0.021	0.1142	0.1142
Brugia malayi	putative neuropeptide receptor NPR1	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0007	0.0007
Brugia malayi	Protein kinase domain containing protein	0.0028	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0297	0.0297
Echinococcus granulosus	apoptotic protease activating factor 1	0.0041	0.0138	0.0138
Echinococcus granulosus	ribonucleoside diphosphate reductase subunit	0.0071	0.032	0.032
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0093	0.0448	0.0448
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.0071	0.032	0.032
Schistosoma mansoni	opsin-like receptor	0.0019	0.0007	0.0007
Trypanosoma brucei	RNA helicase, putative	0.0108	0.0539	0.0539
Brugia malayi	GnHR receptor homolog	0.0019	0.0007	0.0007
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0399	0.2264	0.2264
Schistosoma mansoni	serine-type protease inhibitor	0.0885	0.5147	0.5147
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Brugia malayi	neuropeptide F receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0273	0.1515	0.1515
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Onchocerca volvulus	Netrin receptor homolog	0.0028	0.0063	0.2374
Echinococcus granulosus	GPCR family 2	0.0126	0.0645	0.0645
Loa Loa (eye worm)	ribonucleoside-diphosphate reductase large subunit	0.1702	1	1
Trichomonas vaginalis	meiosis-specific recA homolog Dmc1	0.0024	0.0038	0.0044
Plasmodium falciparum	ribonucleoside-diphosphate reductase large subunit, putative	0.1702	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0025	0.0046	0.0046
Schistosoma mansoni	hypothetical protein	0.0126	0.0645	0.0645
Loa Loa (eye worm)	TYRA-2 protein	0.0019	0.0007	0.0007
Echinococcus granulosus	7tm_1 domain containing protein	0.0019	0.0007	0.0007
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0052	0.0207	0.0207
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0007	0.0007
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.0007	0.0007
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0052	0.0207	1
Leishmania major	ribonucleoside-diphosphate reductase small chain, putative	0.0071	0.032	0.032
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0007	0.0007
Echinococcus granulosus	receptor type guanylyl cyclase	0.0025	0.0046	0.0046
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0104	0.0104
Brugia malayi	Kelch motif family protein	0.0047	0.0173	0.0173
Brugia malayi	Serotonin receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0007	0.0007
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.0024	0.004	0.004
Echinococcus multilocularis	integrin beta 2	0.0228	0.1248	0.1248
Schistosoma mansoni	hypothetical protein	0.0126	0.0645	0.0645
Schistosoma mansoni	protein kinase	0.0025	0.0046	0.0046
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.0071	0.032	0.032
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0025	0.0046	0.0046
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0007	0.0007
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0019	0.0007	0.0007
Brugia malayi	Receptor family ligand binding region containing protein	0.0025	0.0046	0.0046
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0052	0.0207	0.0237
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0028	0.0063	0.0063
Brugia malayi	G-protein coupled receptor	0.0019	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0019	0.0007	0.0007
Echinococcus granulosus	fmrfamide receptor	0.0019	0.0007	0.0007
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0019	0.0007	0.0007
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0007	0.0007
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0093	0.0447	0.0447
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0007	0.0007
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Wolbachia endosymbiont of Brugia malayi	ribonucleotide-diphosphate reductase subunit alpha	0.1491	0.8745	1
Echinococcus granulosus	neuropeptide receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	calcium-activated potassium channel	0.021	0.1142	0.1142
Echinococcus multilocularis	neuropeptide s receptor	0.0019	0.0007	0.0007
Brugia malayi	Protein kinase domain containing protein	0.0036	0.011	0.011
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0019	0.0007	0.0007
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0007	0.0007
Mycobacterium ulcerans	ribonucleotide-diphosphate reductase subunit alpha	0.1491	0.8745	1
Trypanosoma brucei	proteasome beta 6 subunit	0.0052	0.0207	0.0207
Trypanosoma cruzi	ribonucleoside-diphosphate reductase small chain, putative	0.0071	0.032	0.032
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Brugia malayi	neuropeptide F receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0019	0.0007	0.0007
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0108	0.0539	0.0539
Schistosoma mansoni	opsin-like receptor	0.0019	0.0007	0.0007
Plasmodium falciparum	ribonucleoside-diphosphate reductase small chain, putative	0.0071	0.032	0.032
Trypanosoma cruzi	DNA repair protein RAD51, putative	0.0024	0.0038	0.0038
Chlamydia trachomatis	transcriptional repressor NrdR	0.0211	0.1151	0.0858
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0019	0.0007	0.0007
Echinococcus granulosus	g-protein coupled receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0052	0.0207	0.0207
Echinococcus multilocularis	neuropeptide receptor	0.0019	0.0007	0.0007
Plasmodium vivax	ribonucleoside-diphosphate reductase small chain, putative	0.0071	0.032	0.032
Loa Loa (eye worm)	integrin beta-2	0.0308	0.1721	0.1721
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0007	0.0007
Echinococcus multilocularis	dna repair protein rad51 1	0.0024	0.0038	0.0038
Schistosoma mansoni	hypothetical protein	0.0028	0.0063	0.0063
Schistosoma mansoni	amine GPCR	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0063	0.0063
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0022	0.0026	0.0026
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Schistosoma mansoni	calcium-activated potassium channel	0.0136	0.07	0.07
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0007	0.0007
Leishmania major	ribonucleoside-diphosphate reductase small chain, putative	0.0071	0.032	0.032
Brugia malayi	G protein-coupled receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0019	0.0007	0.0007
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0007	0.0007
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.0007	0.0007
Echinococcus granulosus	orexin receptor type 2	0.0019	0.0007	0.0007
Schistosoma mansoni	ankyrin 23/unc44	0.0028	0.0063	0.0063
Echinococcus granulosus	kelch ECH associated protein 1	0.0093	0.0447	0.0447
Leishmania major	ribonucleoside-diphosphate reductase large chain, putative	0.1702	1	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0019	0.0007	0.0007
Echinococcus multilocularis	G protein coupled receptor 139	0.0019	0.0007	0.0007
Schistosoma mansoni	integrin beta subunit	0.0181	0.0971	0.0971
Echinococcus granulosus	death domain containing protein	0.0028	0.0063	0.0063
Brugia malayi	hypothetical protein	0.0019	0.0007	0.0007
Plasmodium vivax	ribonucleotide reductase small subunit, putative	0.0024	0.004	0.004
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0019	0.0007	0.0007
Trypanosoma cruzi	meiotic recombination protein DMC1, putative	0.0024	0.0038	0.0038
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	melatonin receptor type 1A	0.0019	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0019	0.0007	0.0007
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0052	0.0207	0.0207
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0522	0.2992	0.2992
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.0007	0.0007
Plasmodium vivax	ribonucleoside-diphosphate reductase large chain, putative	0.1702	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0007	0.0007
Echinococcus granulosus	neuropeptide receptor	0.0019	0.0007	0.0007
Trypanosoma cruzi	meiotic recombination protein DMC1, putative	0.0024	0.0038	0.0038
Echinococcus multilocularis	somatostatin receptor	0.0019	0.0007	0.0007
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0007	0.0007
Echinococcus granulosus	integrin beta 2	0.0228	0.1248	0.1248
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.0007	0.0007
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0019	0.0007	0.0007
Echinococcus granulosus	somatostatin receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein)	0.1491	0.8745	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0028	0.0063	0.0063
Schistosoma mansoni	myosin xvIII	0.0019	0.0007	0.0007
Echinococcus granulosus	dna repair protein rad51 1	0.0024	0.0038	0.0038
Brugia malayi	AKH receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0019	0.0007	0.0007
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0019	0.0007	0.0007
Brugia malayi	ORL1-like opioid receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	TK/ROR protein kinase	0.0036	0.011	0.011
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.0007	0.0007
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0052	0.0207	0.0207
Echinococcus multilocularis	Ankyrin	0.0028	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0276	0.0276
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0007	0.0007
Schistosoma mansoni	amine GPCR	0.0019	0.0007	0.0007
Echinococcus multilocularis	serotonin receptor	0.0019	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0041	0.0138	0.0138
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0019	0.0007	0.0007
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.0007	0.0007
Echinococcus multilocularis	neuropeptide receptor A26	0.0019	0.0007	0.0007
Brugia malayi	RE15519p	0.0019	0.0007	0.0007
Plasmodium falciparum	ribonucleoside-diphosphate reductase small chain, putative	0.0024	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0019	0.0007	0.0007
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0104	0.0104
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0126	0.0645	0.0645
Trypanosoma brucei	ribonucleoside-diphosphate reductase large chain	0.1702	1	1
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.0457	0.2611	0.2611
Echinococcus multilocularis	netrin receptor unc 5	0.0028	0.0063	0.0063
Onchocerca volvulus	Cell death protein 3 homolog	0.0058	0.0242	1
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.0007	0.0007
Brugia malayi	Peripheral plasma membrane protein CASK	0.0021	0.0019	0.0019
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0126	0.0645	0.0645
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0019	0.0007	0.0007
Brugia malayi	proteasome subunit beta type 1	0.0052	0.0207	0.0207
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.1702	1	1
Loa Loa (eye worm)	hypothetical protein	0.021	0.1142	0.1142
Brugia malayi	Death domain containing protein	0.0028	0.0063	0.0063
Schistosoma mansoni	tumor necrosis factor receptor related	0.0043	0.015	0.015
Schistosoma mansoni	amine GPCR	0.0019	0.0007	0.0007
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.0007	0.0007
Brugia malayi	follicle stimulating hormone receptor	0.0019	0.0007	0.0007
Brugia malayi	G-protein coupled receptor	0.0019	0.0007	0.0007
Echinococcus multilocularis	GPCR, family 2	0.0126	0.0645	0.0645
Toxoplasma gondii	kringle domain-containing protein	0.0035	0.0104	0.0104
Brugia malayi	Uncoordinated protein 44	0.0028	0.0063	0.0063
Brugia malayi	Kringle domain containing protein	0.0035	0.0104	0.0104
Brugia malayi	hypothetical protein	0.0047	0.0173	0.0173
Schistosoma mansoni	neuropeptide f receptor 76f	0.0019	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0019	0.0007	0.0007
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0019	0.0007	0.0007
Echinococcus granulosus	neuropeptide receptor A26	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Brugia malayi	Latrophilin receptor protein 2	0.0126	0.0645	0.0645
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Echinococcus granulosus	disks large 3	0.0048	0.018	0.018
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0126	0.0645	0.0645
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.0007	0.0007
Echinococcus multilocularis	tissue type plasminogen activator	0.0035	0.0104	0.0104
Echinococcus multilocularis	tumor necrosis factor receptor superfamily	0.0043	0.015	0.015
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0007	0.0007
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0019	0.0007	0.0007
Echinococcus multilocularis	serotonin receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Mycobacterium tuberculosis	Probable transcriptional regulatory protein NrdR	0.0211	0.1151	0.0986
Echinococcus granulosus	neuropeptide FF receptor 2	0.0019	0.0007	0.0007
Echinococcus multilocularis	orexin receptor type 2	0.0019	0.0007	0.0007
Leishmania major	RAD51/dmc1 protein	0.0024	0.0038	0.0038
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0126	0.0645	0.0645
Brugia malayi	Dopamine receptor protein 2	0.0019	0.0007	0.0007
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.021	0.1142	0.1142
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0173	0.0173
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0019	0.0007	0.0007
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.0007	0.0007
Echinococcus granulosus	7TM GPCR rhodopsin	0.0019	0.0007	0.0007
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.0071	0.032	0.032
Echinococcus multilocularis	sex peptide receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	amine GPCR	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Brugia malayi	larval opioid receptor	0.0019	0.0007	0.0007
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0007	0.0007
Brugia malayi	ribonucleotide reductase 2	0.0071	0.032	0.032
Schistosoma mansoni	cell polarity protein	0.0018	0.0003	0.0003
Schistosoma mansoni	caspase-7 (C14 family)	0.0058	0.0242	0.0242
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0019	0.0007	0.0007
Brugia malayi	latrophilin 2 splice variant baaae	0.0273	0.1515	0.1515
Brugia malayi	Integrin beta pat-3 precursor	0.0308	0.1721	0.1721
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0019	0.0007	0.0007
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0007	0.0007
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0035	0.0104	0.0104
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0019	0.0007	0.0007
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0007	0.0007
Brugia malayi	Melatonin receptor type 1A	0.0019	0.0007	0.0007
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0052	0.0207	0.0207
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0007	0.0007
Onchocerca volvulus		0.0035	0.0104	0.4139
Schistosoma mansoni	neuropeptide F-like receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0019	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0019	0.0007	0.0007
Trypanosoma cruzi	DNA repair protein RAD51, putative	0.0024	0.0038	0.0038
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0028	0.0063	0.0063
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0007	0.0007
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.0007	0.0007
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.0007	0.0007
Echinococcus multilocularis	neuropeptide receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	serine-type protease inhibitor	0.0885	0.5147	0.5147
Schistosoma mansoni	adenoreceptor	0.0019	0.0007	0.0007
Brugia malayi	Dopamine receptor	0.0019	0.0007	0.0007
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0052	0.0207	0.0207
Loa Loa (eye worm)	rad51	0.0024	0.0038	0.0038
Echinococcus multilocularis	small conductance calcium activated potassium	0.021	0.1142	0.1142
Echinococcus granulosus	netrin receptor unc 5	0.0028	0.0063	0.0063
Echinococcus granulosus	TNFR CD27 30 40 95 cysteine rich region	0.0043	0.015	0.015
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0019	0.0007	0.0007
Brugia malayi	Guanylate kinase family protein	0.0053	0.0209	0.0209
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0007	0.0007
Echinococcus granulosus	allatostatin A receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Echinococcus multilocularis	ribonucleoside diphosphate reductase large	0.1702	1	1
Mycobacterium ulcerans	ribonucleotide-diphosphate reductase subunit beta	0.0024	0.004	0.0031
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0007	0.0007
Mycobacterium tuberculosis	Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase)	0.0536	0.3078	0.3273
Toxoplasma gondii	ribonucleoside-diphosphate reductase small subunit	0.0071	0.032	0.032
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0273	0.1515	0.1515
Echinococcus multilocularis	allatostatin A receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	histamine h1 receptor	0.0019	0.0007	0.0007
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0019	0.0007	0.0007
Echinococcus multilocularis	caspase 2	0.0058	0.0242	0.0242
Schistosoma mansoni	amine GPCR	0.0019	0.0007	0.0007
Brugia malayi	sulfakinin receptor protein	0.0019	0.0007	0.0007
Onchocerca volvulus		0.0021	0.0019	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Brugia malayi	Dopamine receptor protein 1	0.0019	0.0007	0.0007
Schistosoma mansoni	neuropeptide F-like receptor	0.0019	0.0007	0.0007
Echinococcus granulosus	sex peptide receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0019	0.0007	0.0007
Echinococcus multilocularis	dro:myosuppressin receptor	0.0019	0.0007	0.0007
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0126	0.0645	0.0645
Echinococcus granulosus	biogenic amine 5HT receptor	0.0019	0.0007	0.0007
Echinococcus multilocularis	Kelch repeat type 1	0.0093	0.0448	0.0448
Brugia malayi	putative neuropeptide receptor	0.0019	0.0007	0.0007
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain, putative	0.0071	0.032	0.032
Mycobacterium ulcerans	transcriptional regulator NrdR	0.0211	0.1151	0.1303
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0126	0.0645	0.0645
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0052	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0138	0.0138
Brugia malayi	Cell death protein 3 precursor	0.0058	0.0242	0.0242
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0019	0.0007	0.0007
Mycobacterium leprae	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN)	0.1491	0.8745	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0019	0.0007	0.0007
Echinococcus granulosus	dro:myosuppressin receptor	0.0019	0.0007	0.0007
Echinococcus granulosus	biogenic amine 5HT receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0007	0.0007
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0007	0.0007
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0041	0.0138	0.0138
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0093	0.0447	0.0447
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0126	0.0645	0.0645
Schistosoma mansoni	ribonucleoside-diphosphate reductase alpha subunit	0.1702	1	1
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0047	0.0173	0.0173
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0007	0.0007
Echinococcus multilocularis	kelch ECH associated protein 1	0.0093	0.0447	0.0447
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.0007	0.0007
Brugia malayi	DNA repair protein RAD51 homolog 1	0.0024	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Treponema pallidum	ribonucleotide-diphosphate reductase subunit alpha	0.1702	1	1
Echinococcus granulosus	tumor necrosis factor receptor superfamily	0.0043	0.015	0.015
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0019	0.0007	0.0007
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0028	0.0063	0.0063
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0052	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Brugia malayi	G protein-coupled receptor F59B2.13	0.0019	0.0007	0.0007
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0399	0.2264	0.2264
Loa Loa (eye worm)	ribonucleotide reductase M2 B	0.0071	0.032	0.032
Onchocerca volvulus		0.0041	0.0138	0.5585
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0645	0.0645
Brugia malayi	hypothetical protein	0.0019	0.0007	0.0007
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0019	0.0007	0.0007
Trypanosoma cruzi	ribonucleoside-diphosphate reductase small chain, putative	0.0071	0.032	0.032
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0242	0.0242
Schistosoma mansoni	cell polarity protein	0.0048	0.018	0.018
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0025	0.0046	0.0046
Toxoplasma gondii	meiotic recombination protein DMC1 family protein	0.0024	0.0038	0.0038
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0041	0.0138	0.0138
Echinococcus granulosus	hypothetical protein	0.0019	0.0007	0.0007
Chlamydia trachomatis	ribonucleoside-diphosphate reductase subunit alpha	0.1702	1	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Echinococcus granulosus	tissue type plasminogen activator	0.0035	0.0104	0.0104
Giardia lamblia	Proteasome subunit beta type 1	0.0052	0.0207	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0007	0.0007
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0019	0.0007	0.0007
Echinococcus multilocularis	g-protein coupled receptor	0.0019	0.0007	0.0007
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0025	0.0046	0.1684
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0022	0.0026	0.0026
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0052	0.0207	0.0207
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0019	0.0007	0.0007
Echinococcus multilocularis	ribonucleoside diphosphate reductase subunit	0.0071	0.032	0.032
Loa Loa (eye worm)	lethal(1)discs large-1 tumor suppressor	0.0045	0.0164	0.0164
Toxoplasma gondii	ribonucleoside-diphosphate reductase large chain	0.1702	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0035	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Echinococcus multilocularis	disks large 3	0.0048	0.018	0.018
Echinococcus multilocularis	kelch ECH associated protein 1	0.0093	0.0447	0.0447
Echinococcus multilocularis	TNFR CD27 30 40 95 cysteine rich region	0.0043	0.015	0.015
Brugia malayi	Serotonin receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	guanylate kinase	0.004	0.0131	0.0131
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0007	0.0007
Schistosoma mansoni	netrin receptor unc5	0.0028	0.0063	0.0063
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0019	0.0007	0.0007
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0019	0.0007	0.0007
Echinococcus granulosus	tm gpcr rhodopsin	0.0522	0.2992	0.2992
Schistosoma mansoni	ribonucleoside-diphosphate reductase small chain	0.0071	0.032	0.032
Echinococcus granulosus	G protein coupled receptor 139	0.0019	0.0007	0.0007
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0019	0.0007	0.0007
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0007	0.0007
Schistosoma mansoni	growth hormone secretagogue receptor	0.0019	0.0007	0.0007
Echinococcus granulosus	caspase 2	0.0058	0.0242	0.0242
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0399	0.2264	0.2264
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0019	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0399	0.2264	0.2264
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0052	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0071	0.032	0.032
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0126	0.0645	0.0645
Plasmodium falciparum	cysteine repeat modular protein 1	0.0035	0.0104	0.0104
Trichomonas vaginalis	ribonucleoside-diphosphate reductase alpha chain, putative	0.1491	0.8745	1

Activities

Activity type	Activity value	Assay description	Source	Reference
EMR (binding)	= 0.17	Ratio of concentration drug to dequalinium to cause 50% inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons	ChEMBL.	17560109
EMR (binding)	= 0.17	Ratio of concentration drug to dequalinium to cause 50% inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons	ChEMBL.	17560109
IC50 (binding)	= 0.093 uM	Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons	ChEMBL.	17560109
IC50 (binding)	= 0.093 uM	Inhibition of SKca channel-mediated after-hypepolarization in rat sympathetic neurons	ChEMBL.	17560109

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL375272

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 425335