Detailed information for compound 429386

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 513.647 | Formula: C27H48NO6P
  • H donors: 4 H acceptors: 5 LogP: 6.42 Rotable bonds: 22
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCCCCCCCCCC(=O)N[C@H](C(CP(=O)(O)O)O)Cc1ccc(cc1)OC
  • InChi: 1S/C27H48NO6P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-27(30)28-25(26(29)22-35(31,32)33)21-23-17-19-24(34-2)20-18-23/h17-20,25-26,29H,3-16,21-22H2,1-2H3,(H,28,30)(H2,31,32,33)/t25-,26?/m0/s1
  • InChiKey: NTUITPWAHFMEDD-PMCHYTPCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0019
Schistosoma mansoni myosin xvIII 0.0066 0.0609 0.0609
Entamoeba histolytica protein kinase, putative 0.0324 0.3481 1
Onchocerca volvulus 0.0066 0.0609 0.1778
Echinococcus granulosus hypothetical protein 0.0066 0.0609 0.0609
Brugia malayi nuclear receptor RXR 0.0016 0.0051 0.0019
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0066 0.0609 0.058
Giardia lamblia Kinase, CMGC DYRK 0.0324 0.3481 1
Brugia malayi nuclear hormone receptor 0.0031 0.0212 0.0181
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0212 0.0212
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0212 0.0181
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0054 0.0054
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0604 0.0604
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0066 0.0609 0.0609
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0032 0.0032
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0154 0.1582 0.1582
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0066 0.0609 0.058
Loa Loa (eye worm) carboxylesterase 0.0909 1 1
Leishmania major hypothetical protein, conserved 0.0015 0.0035 0.0048
Loa Loa (eye worm) haspin protein kinase 0.0419 0.4538 0.4521
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0047 0.0016
Loa Loa (eye worm) microfilarial chitinase 0.0071 0.0661 0.0632
Plasmodium falciparum conserved protein, unknown function 0.0116 0.1161 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0154 0.1582 1
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0341 0.0341
Brugia malayi Protein kinase domain containing protein 0.0075 0.0703 0.0673
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0212 0.0212
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Schistosoma mansoni bromodomain containing protein 0.0061 0.0553 0.0553
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0066 0.0609 0.058
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0212 0.0181
Schistosoma mansoni BC026374 protein (S09 family) 0.0154 0.1582 0.1582
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0212 0.0181
Onchocerca volvulus 0.0116 0.1161 0.3474
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0416 0.4507 0.4507
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Loa Loa (eye worm) G-protein coupled receptor 0.0066 0.0609 0.058
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Schistosoma mansoni hypothetical protein 0.0116 0.1161 0.1161
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0253
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0054 0.0054
Brugia malayi neuropeptide F receptor 0.0066 0.0609 0.058
Brugia malayi putative neuropeptide receptor 0.0066 0.0609 0.058
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0703 0.0703
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0609 0.0609
Brugia malayi hypothetical protein 0.0066 0.0609 0.058
Loa Loa (eye worm) hypothetical protein 0.0154 0.1582 0.1555
Onchocerca volvulus 0.0066 0.0609 0.1778
Echinococcus multilocularis G protein coupled receptor 139 0.0066 0.0609 0.0609
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0609 0.0609
Brugia malayi AKH receptor 0.0066 0.0609 0.058
Schistosoma mansoni neuropeptide F-like receptor 0.0066 0.0609 0.0609
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0703 0.1976
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0066 0.0609 0.0609
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0212 0.0181
Echinococcus granulosus 7TM GPCR rhodopsin 0.0066 0.0609 0.0609
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0041 0.0041
Schistosoma mansoni neuropeptide receptor 0.0066 0.0609 0.0609
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0032 0.0032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.0609 0.0609
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0212 0.0181
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Echinococcus multilocularis geminin 0.0164 0.1698 0.1698
Echinococcus multilocularis neuropeptide FF receptor 2 0.0066 0.0609 0.0609
Onchocerca volvulus Putative endochitinase 0.0073 0.0683 0.2005
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0159 0.106
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Echinococcus granulosus g-protein coupled receptor 0.0066 0.0609 0.0609
Echinococcus multilocularis g protein coupled receptor 0.0066 0.0609 0.0609
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0041 0.0063
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.0703 0.1976
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0212 0.0181
Echinococcus multilocularis neuropeptide receptor 0.0066 0.0609 0.0609
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0212 0.0212
Echinococcus granulosus neuropeptide s receptor 0.0066 0.0609 0.0609
Echinococcus granulosus dro:myosuppressin receptor 0.0066 0.0609 0.0609
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.0609 0.0609
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0609 0.0609
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0212 0.0181
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.0609 0.0609
Onchocerca volvulus 0.0066 0.0609 0.1778
Schistosoma mansoni hypothetical protein 0.0034 0.0253 0.0253
Echinococcus multilocularis neuropeptide receptor A26 0.0066 0.0609 0.0609
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0212 0.0212
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0148 0.0374
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Schistosoma mansoni gliotactin 0.0154 0.1582 0.1582
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0032 0.0032
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.0609 0.0609
Schistosoma mansoni hypothetical protein 0.0416 0.4507 0.4507
Brugia malayi nuclear receptor NHR-88 0.0031 0.0212 0.0181
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.0703 0.1976
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0066 0.0609 0.0609
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0212 0.0181
Echinococcus granulosus g protein coupled receptor 0.0066 0.0609 0.0609
Echinococcus multilocularis g protein coupled receptor 0.0066 0.0609 0.0609
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0609 0.0609
Echinococcus granulosus dual specificity 0.0324 0.3481 0.3481
Echinococcus granulosus zinc finger protein 0.0019 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Brugia malayi hypothetical protein 0.0016 0.0051 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0212 0.0181
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0148 0.0148
Schistosoma mansoni coup transcription factor 0.0031 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0031 0.0212 0.0181
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0066 0.0609 0.0609
Echinococcus multilocularis orexin receptor type 2 0.0066 0.0609 0.0609
Schistosoma mansoni adenoreceptor 0.0066 0.0609 0.0609
Echinococcus multilocularis GPCR, family 2 0.0016 0.0047 0.0047
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0041 0.0063
Echinococcus granulosus neuropeptide Y receptor 0.0066 0.0609 0.0609
Brugia malayi Tachykinin-like peptides receptor 99D 0.0066 0.0609 0.058
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0041 0.0041
Brugia malayi cyclin-dependent kinase 7 homolog 0.0075 0.0703 0.0673
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0031 0.0212 0.0181
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0609 0.0609
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0212 0.0212
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0609 0.0609
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0148 0.0117
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0113 0.0113
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Schistosoma mansoni neuroligin 3 (S09 family) 0.0154 0.1582 0.1582
Onchocerca volvulus 0.0066 0.0609 0.1778
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0032 0.0032
Onchocerca volvulus 0.0066 0.0609 0.1778
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0066 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0026 0.0159 0.0128
Brugia malayi ORL1-like opioid receptor 0.0066 0.0609 0.058
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0212 0.0181
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0154 0.1582 0.1582
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0041 0.0041
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0066 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0041 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0016
Onchocerca volvulus 0.0154 0.1582 0.4771
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Loa Loa (eye worm) G-protein coupled receptor 0.0066 0.0609 0.058
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0212 0.0212
Onchocerca volvulus 0.0066 0.0609 0.1778
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0159 0.0406
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.0609 0.0609
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0032 0.0032
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0047 0.0047
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0066 0.0609 0.0609
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0212 0.0212
Brugia malayi isocitrate dehydrogenase 0.0015 0.0041 0.0009
Loa Loa (eye worm) hypothetical protein 0.0031 0.0212 0.0181
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0324 0.3481 1
Brugia malayi hypothetical protein 0.0154 0.1582 0.1555
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0212 0.0212
Onchocerca volvulus 0.0066 0.0609 0.1778
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0416 0.4507 0.4507
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0212 0.0181
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Schistosoma mansoni biogenic amine receptor 0.0066 0.0609 0.0609
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0324 0.3481 1
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0116 0.1161 0.1133
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Schistosoma mansoni opsin-like receptor 0.0066 0.0609 0.0609
Mycobacterium tuberculosis Possible chitinase 0.0062 0.0563 0.3391
Loa Loa (eye worm) hypothetical protein 0.0031 0.0212 0.0181
Echinococcus multilocularis dro:myosuppressin receptor 0.0066 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0909 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0066 0.0609 0.0609
Onchocerca volvulus 0.0116 0.1161 0.3474
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0604 0.0574
Brugia malayi PHD-finger family protein 0.0024 0.0139 0.0108
Echinococcus multilocularis dual specificity 0.0324 0.3481 0.3481
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0212 0.0212
Brugia malayi hypothetical protein 0.0066 0.0609 0.058
Entamoeba histolytica hypothetical protein 0.0042 0.0341 0.0932
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0058 0.0157
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0047 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0159 0.106
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0066 0.0609 0.0609
Leishmania major serine/threonine kinase-like protein, putative 0.0075 0.0703 0.1976
Echinococcus granulosus dual specificity 0.0324 0.3481 0.3481
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0609 0.0609
Echinococcus granulosus serine:threonine protein kinase haspin 0.0416 0.4507 0.4507
Trichomonas vaginalis CMGC family protein kinase 0.0324 0.3481 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0066 0.0609 0.0609
Brugia malayi hypothetical protein 0.0306 0.3281 0.326
Echinococcus multilocularis fmrfamide receptor 0.0066 0.0609 0.0609
Schistosoma mansoni zinc finger protein 0.0015 0.0035 0.0035
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0609 0.0609
Onchocerca volvulus 0.0154 0.1582 0.4771
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0609 0.0609
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0609 0.0609
Brugia malayi Carboxylesterase family protein 0.0909 1 1
Onchocerca volvulus 0.0066 0.0609 0.1778
Loa Loa (eye worm) neuropeptide F receptor 0.0066 0.0609 0.058
Echinococcus multilocularis allatostatin A receptor 0.0066 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0154 0.1582 0.1555
Schistosoma mansoni neuropeptide f receptor 76f 0.0066 0.0609 0.0609
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0212 0.0212
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0066 0.0609 0.0609
Onchocerca volvulus 0.0066 0.0609 0.1778
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0066 0.0609 0.058
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0066 0.0609 0.058
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0212 0.0556
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0041 0.0063
Loa Loa (eye worm) hypothetical protein 0.0154 0.1582 0.1555
Echinococcus granulosus GPCR family 2 0.0016 0.0047 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Brugia malayi neuropeptide F receptor 0.0066 0.0609 0.058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0703 0.1976
Onchocerca volvulus Putative endochitinase 0.0082 0.0781 0.2306
Onchocerca volvulus Neuropeptide F receptor homolog 0.0066 0.0609 0.1778
Schistosoma mansoni zinc finger protein 0.0019 0.0081 0.0081
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0703 0.1976
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0154 0.1582 0.1582
Toxoplasma gondii hypothetical protein 0.0116 0.1161 0.3255
Echinococcus granulosus neuropeptide receptor 0.0066 0.0609 0.0609
Echinococcus granulosus neuropeptide receptor A26 0.0066 0.0609 0.0609
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0159 0.106
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0066 0.0609 0.0609
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0212 0.0212
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0159 0.0406
Brugia malayi ecdysteroid receptor 0.0031 0.0212 0.0181
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0212 0.0212
Onchocerca volvulus 0.0306 0.3281 1
Schistosoma mansoni hypothetical protein 0.0016 0.0047 0.0047
Echinococcus multilocularis zinc finger protein 0.0019 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Loa Loa (eye worm) haspin protein kinase 0.0416 0.4507 0.449
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0075 0.0703 0.5913
Loa Loa (eye worm) hypothetical protein 0.0154 0.1582 0.1555
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0066 0.0609 0.1778
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0066 0.0609 0.0609
Echinococcus granulosus g protein coupled receptor 0.0066 0.0609 0.0609
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.0075 0.0703 0.1976
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.043 0.04
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0032 0.0032
Schistosoma mansoni nuclear receptor 0.0014 0.0032 0.0032
Leishmania major chitinase 0.0073 0.0683 0.1919
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0051 0.0051
Echinococcus multilocularis neuropeptides capa receptor 0.0066 0.0609 0.0609
Onchocerca volvulus 0.0154 0.1582 0.4771
Loa Loa (eye worm) hypothetical protein 0.0116 0.1161 0.1133
Echinococcus multilocularis somatostatin receptor 0.0066 0.0609 0.0609
Echinococcus granulosus serine:threonine protein kinase haspin 0.0416 0.4507 0.4507
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0066 0.0609 0.0609
Loa Loa (eye worm) cuticular endochitinase 0.0073 0.0683 0.0653
Brugia malayi endochitinase 0.0073 0.0683 0.0653
Echinococcus granulosus serine:threonine protein kinase haspin 0.0416 0.4507 0.4507
Loa Loa (eye worm) hypothetical protein 0.0068 0.0633 0.0603
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.0075 0.0703 0.1976
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0253 0.0222
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0016 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Brugia malayi Melatonin receptor type 1A 0.0066 0.0609 0.058
Brugia malayi Carboxylesterase family protein 0.0154 0.1582 0.1555
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.002 0.0093 0.0093
Brugia malayi hypothetical protein 0.0066 0.0609 0.058
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Trypanosoma brucei ISWI complex protein 0.0015 0.0035 0.0048
Echinococcus multilocularis G-protein coupled receptor, putative 0.0066 0.0609 0.0609
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0258 0.0258
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0212 0.0212
Schistosoma mansoni biogenic amine receptor 0.0066 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0075 0.0703 0.0673
Echinococcus multilocularis neuropeptide Y receptor 0.0066 0.0609 0.0609
Brugia malayi hypothetical protein 0.0066 0.0609 0.058
Brugia malayi hypothetical protein 0.0042 0.0341 0.0311
Trichomonas vaginalis CMGC family protein kinase 0.0324 0.3481 1
Echinococcus granulosus para nitrobenzyl esterase 0.0154 0.1582 0.1582
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0609 0.0609
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Echinococcus multilocularis carboxylesterase 5A 0.0909 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0051 0.0019
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0047 0.0016
Schistosoma mansoni opsin-like receptor 0.0066 0.0609 0.0609
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.0609 0.0609
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0341 0.0341
Echinococcus multilocularis cyclin dependent kinase 9 0.0075 0.0703 0.0703
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0019
Echinococcus granulosus geminin 0.0164 0.1698 0.1698
Schistosoma mansoni hypothetical protein 0.0072 0.0672 0.0672
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0212 0.0212
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0212 0.0212
Echinococcus granulosus neuropeptides capa receptor 0.0066 0.0609 0.0609
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0604 0.0604
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Schistosoma mansoni opsin-like receptor 0.0066 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0075 0.0703 0.0703
Echinococcus granulosus neuropeptides capa receptor 0.0066 0.0609 0.0609
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0066 0.0609 0.058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0212 0.0181
Echinococcus multilocularis para nitrobenzyl esterase 0.0154 0.1582 0.1582
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0212 0.0212
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0703 0.1976
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0066 0.0609 0.0609
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0514 0.0514
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Echinococcus multilocularis neuropeptide s receptor 0.0066 0.0609 0.0609
Brugia malayi Cell division protein kinase 2 0.0075 0.0703 0.0673
Schistosoma mansoni neuropeptide receptor 0.0066 0.0609 0.0609
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0609 0.0609
Brugia malayi Dopamine receptor protein 1 0.0066 0.0609 0.058
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0324 0.3481 0.346
Schistosoma mansoni amine GPCR 0.0066 0.0609 0.0609
Echinococcus granulosus tachykinin peptides receptor 99D 0.0066 0.0609 0.0609
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0212 0.0181
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0324 0.3481 0.346
Brugia malayi hypothetical protein 0.0017 0.0057 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0604 0.0604
Onchocerca volvulus 0.0154 0.1582 0.4771
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0061 0.0029
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Loa Loa (eye worm) hypothetical protein 0.0031 0.0212 0.0181
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0041 0.0041
Echinococcus granulosus bloom syndrome protein 0.0025 0.0148 0.0148
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Schistosoma mansoni hypothetical protein 0.0066 0.0609 0.0609
Echinococcus multilocularis dual specificity 0.0324 0.3481 0.3481
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Echinococcus multilocularis BC026374 protein (S09 family) 0.0154 0.1582 0.1582
Echinococcus multilocularis acetylcholinesterase 0.0909 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0066 0.0609 0.0609
Schistosoma mansoni hypothetical protein 0.0042 0.0341 0.0341
Brugia malayi Endochitinase 0.0082 0.0781 0.0752
Trypanosoma cruzi ISWI complex protein 0.0015 0.0035 0.0048
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0051 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0212 0.0181
Brugia malayi RNA binding protein 0.0066 0.0604 0.0574
Schistosoma mansoni hypothetical protein 0.0015 0.0035 0.0035
Echinococcus granulosus tar DNA binding protein 0.0066 0.0604 0.0604
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0909 1 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0075 0.0703 0.1976
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0056 0.0045
Brugia malayi Bromodomain containing protein 0.0073 0.0679 0.065
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Echinococcus granulosus BC026374 protein S09 family 0.0154 0.1582 0.1582
Onchocerca volvulus 0.0066 0.0609 0.1778
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0032 0.0032
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0212 0.0181
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0054 0.0054
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0019
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0066 0.0609 0.0609
Trichomonas vaginalis CMGC family protein kinase 0.0324 0.3481 1
Echinococcus multilocularis neuropeptide receptor 0.0066 0.0609 0.0609
Onchocerca volvulus 0.0066 0.0609 0.1778
Echinococcus granulosus orexin receptor type 2 0.0066 0.0609 0.0609
Schistosoma mansoni acetylcholinesterase 0.0154 0.1582 0.1582
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0212 0.0181
Brugia malayi G protein-coupled receptor 0.0066 0.0609 0.058
Loa Loa (eye worm) hypothetical protein 0.005 0.043 0.04
Brugia malayi G-protein coupled receptor 0.0066 0.0609 0.058
Schistosoma mansoni hypothetical protein 0.0066 0.0609 0.0609
Schistosoma mansoni serine/threonine protein kinase 0.0324 0.3481 0.3481
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0212 0.0556
Schistosoma mansoni protein kinase 0.0075 0.0703 0.0703
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Echinococcus multilocularis serotonin receptor 0.0066 0.0609 0.0609
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.043 0.04
Schistosoma mansoni amine GPCR 0.0066 0.0609 0.0609
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0212 0.0181
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0909 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0066 0.0609 0.0609
Echinococcus multilocularis neuropeptides capa receptor 0.0066 0.0609 0.0609
Trichomonas vaginalis CMGC family protein kinase 0.0324 0.3481 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0212 0.0212
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0258 0.0258
Echinococcus granulosus sex peptide receptor 0.0066 0.0609 0.0609
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0154 0.1582 0.4515
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0066 0.0609 0.0609
Echinococcus granulosus fmrfamide receptor 0.0066 0.0609 0.0609
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0032 0.0032
Plasmodium vivax hypothetical protein, conserved 0.0116 0.1161 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0604 0.0604
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Echinococcus granulosus Cell division cycle 2 protein kinase 0.0075 0.0703 0.0703
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Echinococcus granulosus serotonin receptor 0.0066 0.0609 0.0609
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0609 0.0609
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0609 0.0609
Loa Loa (eye worm) carboxylesterase 0.0154 0.1582 0.1555
Brugia malayi Serotonin receptor 0.0066 0.0609 0.058
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0212 0.0181
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0032 0.0032
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.0609 0.0609
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Onchocerca volvulus Putative endochitinase 0.0082 0.0781 0.2306
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0212 0.0212
Brugia malayi Carboxylesterase family protein 0.0154 0.1582 0.1555
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0075 0.0703 0.1976
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0212 0.0181
Echinococcus granulosus alpha 1A adrenergic receptor 0.0066 0.0609 0.0609
Entamoeba histolytica hypothetical protein 0.0072 0.0672 0.1885
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0075 0.0703 0.1976
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Entamoeba histolytica protein kinase domain containing protein 0.0075 0.0703 0.1976
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.0075 0.0703 0.0673
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0032 0.0032
Echinococcus granulosus Pfam-B_8186 domain containing protein 0.0072 0.0672 0.0672
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.0609 0.0609
Leishmania major hypothetical protein, conserved 0.0026 0.0159 0.0406
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0609 0.0609
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0054 0.0054
Brugia malayi Dopamine receptor protein 2 0.0066 0.0609 0.058
Schistosoma mansoni amine GPCR 0.0066 0.0609 0.0609
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0066 0.0609 0.0609
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0212 0.0212
Echinococcus granulosus cyclin dependent kinase 9 0.0075 0.0703 0.0703
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0609 0.0609
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0032 0.0032
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0703 0.1976
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0054 0.0054
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0066 0.0609 0.0609
Brugia malayi follicle stimulating hormone receptor 0.0066 0.0609 0.058
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0212 0.0212
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0041 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0212 0.0181
Echinococcus multilocularis neuroligin 0.0154 0.1582 0.1582
Loa Loa (eye worm) acetylcholinesterase 1 0.0909 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0066 0.0609 0.058
Brugia malayi hypothetical protein 0.0066 0.0609 0.058
Onchocerca volvulus 0.0066 0.0609 0.1778
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0212 0.0181
Schistosoma mansoni nuclear receptor 0.0014 0.0032 0.0032
Echinococcus granulosus neuropeptide FF receptor 2 0.0066 0.0609 0.0609
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0051 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0054 0.0054
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0032 0.0032
Schistosoma mansoni neuropeptide F-like receptor 0.0066 0.0609 0.0609
Echinococcus multilocularis serotonin receptor 0.0066 0.0609 0.0609
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0066 0.0609 0.058
Echinococcus granulosus carboxylesterase 5A 0.0909 1 1
Brugia malayi Bromodomain containing protein 0.0037 0.0283 0.0253
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0066 0.0609 0.0609
Entamoeba histolytica protein kinase domain containing protein 0.0324 0.3481 1
Brugia malayi hypothetical protein 0.0066 0.0609 0.058
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0212 0.0212
Schistosoma mansoni hypothetical protein 0.0164 0.1698 0.1698
Brugia malayi GnHR receptor homolog 0.0066 0.0609 0.058
Brugia malayi Dopamine receptor 0.0066 0.0609 0.058
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Loa Loa (eye worm) TYRA-2 protein 0.0066 0.0609 0.058
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0212 0.0181
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0066 0.0609 0.0609
Echinococcus granulosus acetylcholinesterase 0.0909 1 1
Echinococcus multilocularis hypothetical protein 0.0072 0.0672 0.0672
Brugia malayi hypothetical protein 0.0066 0.0609 0.058
Echinococcus multilocularis dual specificity 0.0324 0.3481 0.3481
Schistosoma mansoni hypothetical protein 0.0066 0.0609 0.0609
Schistosoma mansoni biogenic amine receptor 0.0066 0.0609 0.0609
Onchocerca volvulus 0.0066 0.0609 0.1778
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0212 0.0181
Entamoeba histolytica hypothetical protein 0.0042 0.0341 0.0932
Echinococcus granulosus acetylcholinesterase 0.0909 1 1
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0212 0.0212
Onchocerca volvulus Putative endochitinase 0.0073 0.0683 0.2005
Schistosoma mansoni neuropeptide receptor 0.0066 0.0609 0.0609
Echinococcus granulosus biogenic amine 5HT receptor 0.0066 0.0609 0.0609
Onchocerca volvulus 0.0066 0.0609 0.1778
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.043 0.04
Brugia malayi G protein-coupled receptor F59B2.13 0.0066 0.0609 0.058
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0047 0.0047
Brugia malayi GSG2 0.0416 0.4507 0.449
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0609 0.0609
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0116 0.1161 0.1161
Loa Loa (eye worm) RecQ helicase 0.0025 0.0148 0.0117
Brugia malayi endochitinase 0.0082 0.0781 0.0752
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0609 0.0609
Schistosoma mansoni alpha-1 adrenergic receptor 0.0066 0.0609 0.0609
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0212 0.0212
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0066 0.0609 0.0609
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0703 0.1976
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0041 0.0041
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.0075 0.0703 0.0703
Echinococcus multilocularis fmrfamide receptor 0.0066 0.0609 0.0609
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0093 0.0061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0609 0.0609
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0075 0.0703 0.1976
Schistosoma mansoni hypothetical protein 0.0016 0.0047 0.0047
Brugia malayi TAR-binding protein 0.0066 0.0604 0.0574
Brugia malayi hypothetical protein 0.0016 0.0051 0.0019
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0062 0.0563 0.0533
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Schistosoma mansoni neuropeptide receptor 0.0066 0.0609 0.0609
Echinococcus granulosus 7tm_1 domain containing protein 0.0066 0.0609 0.0609
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0514 0.0514
Brugia malayi sulfakinin receptor protein 0.0066 0.0609 0.058
Brugia malayi steroid hormone receptor 0.0031 0.0212 0.0181
Brugia malayi hypothetical protein 0.0066 0.0609 0.058
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0604 0.0574
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.0703 0.1976
Echinococcus multilocularis g protein coupled receptor 0.0066 0.0609 0.0609
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0066 0.0609 0.0609
Echinococcus granulosus somatostatin receptor 0.0066 0.0609 0.0609
Echinococcus multilocularis acetylcholinesterase 0.0909 1 1
Echinococcus granulosus allatostatin A receptor 0.0066 0.0609 0.0609
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0703 0.1976
Onchocerca volvulus 0.0066 0.0609 0.1778
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0041 0.0009
Echinococcus granulosus G protein coupled receptor 139 0.0066 0.0609 0.0609
Echinococcus granulosus peptide allatostatin:somatostatin 0.0066 0.0609 0.0609
Schistosoma mansoni hypothetical protein 0.0016 0.0047 0.0047
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0341 0.0341
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0154 0.1582 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0253 0.0222
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0154 0.1582 0.1582
Echinococcus multilocularis sex peptide receptor 0.0066 0.0609 0.0609
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0212 0.0212
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0066 0.0609 0.058
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0051 0.0051
Echinococcus granulosus neuroligin 0.0154 0.1582 0.1582
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0113 0.0113
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0066 0.0609 0.0609
Trypanosoma cruzi ISWI complex protein 0.0015 0.0035 0.0048
Trichomonas vaginalis CMGC family protein kinase 0.0324 0.3481 1
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0159 0.0345
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0066 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0041 0.033 0.03
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0116 0.1161 0.1161
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0066 0.0609 0.0609
Brugia malayi Carboxylesterase family protein 0.0154 0.1582 0.1555
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0066 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0126 0.127 0.1242
Trichomonas vaginalis CMGC family protein kinase 0.0324 0.3481 1
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Brugia malayi Serotonin receptor 0.0066 0.0609 0.058
Onchocerca volvulus Putative endochitinase 0.0082 0.0781 0.2306
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Loa Loa (eye worm) hypothetical protein 0.0154 0.1582 0.1555
Onchocerca volvulus 0.0066 0.0609 0.1778
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0032 0.0032
Brugia malayi hypothetical protein 0.0026 0.0159 0.0128
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.0703 0.1976
Echinococcus granulosus neuropeptide Y receptor 0.0066 0.0609 0.0609
Onchocerca volvulus 0.0066 0.0609 0.1778
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.0075 0.0703 0.1976
Trichomonas vaginalis serine/threonine kinase, putative 0.0075 0.0703 0.1976
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0054 0.0054
Brugia malayi Carboxylesterase family protein 0.0154 0.1582 0.1555
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0159 0.0406
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0113 0.0113
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Schistosoma mansoni serine/threonine kinase 0.0075 0.0703 0.0703
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0154 0.1582 0.1582
Schistosoma mansoni hypothetical protein 0.0066 0.0609 0.0609
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.0609 0.0609
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0066 0.0609 0.058
Echinococcus granulosus serine:threonine protein kinase NLK 0.0075 0.0703 0.0703
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0212 0.0181
Brugia malayi G-protein coupled receptor 0.0066 0.0609 0.058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0212 0.0181
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0212 0.0181
Loa Loa (eye worm) carboxylesterase 0.0154 0.1582 0.1555
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0019
Loa Loa (eye worm) hypothetical protein 0.0154 0.1582 0.1555
Entamoeba histolytica hypothetical protein 0.0042 0.0341 0.0932
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0609 0.0609
Entamoeba histolytica hypothetical protein 0.0042 0.0341 0.0932
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0604 0.0604
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0212 0.0212
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0785 0.8617 0.8617
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0324 0.3481 1
Entamoeba histolytica chitinase, putative 0.0073 0.0683 0.1919
Echinococcus granulosus g protein coupled receptor 0.0066 0.0609 0.0609
Schistosoma mansoni biogenic amine (5HT) receptor 0.0066 0.0609 0.0609
Onchocerca volvulus 0.0154 0.1582 0.4771
Schistosoma mansoni amine GPCR 0.0066 0.0609 0.0609
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Schistosoma mansoni growth hormone secretagogue receptor 0.0066 0.0609 0.0609
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0212 0.0212
Loa Loa (eye worm) chitinase I 0.0073 0.0683 0.0653
Echinococcus granulosus dual specificity 0.0324 0.3481 0.3481
Loa Loa (eye worm) hypothetical protein 0.0306 0.3281 0.326
Echinococcus granulosus mitogen activated protein kinase 15 0.0075 0.0703 0.0703
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0604 0.0574
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Schistosoma mansoni amine GPCR 0.0066 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0039 0.031 0.0279
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0041 0.0063
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0324 0.3481 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0212 0.0212
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0066 0.0609 0.058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0212 0.0181
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0148 0.0374
Mycobacterium tuberculosis Carboxylesterase LipT 0.0154 0.1582 1
Brugia malayi hypothetical protein 0.0066 0.0609 0.058
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0032 0.0032
Brugia malayi hypothetical protein 0.0066 0.0609 0.058
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0075 0.0703 0.5913
Trichomonas vaginalis spcc417.12 protein, putative 0.0154 0.1582 0.4515
Loa Loa (eye worm) RNA binding protein 0.0066 0.0604 0.0574
Brugia malayi putative neuropeptide receptor NPR1 0.0066 0.0609 0.058
Onchocerca volvulus 0.0031 0.0212 0.0556
Loa Loa (eye worm) melatonin receptor type 1A 0.0066 0.0609 0.058
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Schistosoma mansoni hypothetical protein 0.0164 0.1698 0.1698
Loa Loa (eye worm) hypothetical protein 0.0116 0.1161 0.1133
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Trypanosoma brucei protein kinase, putative 0.0075 0.0703 0.1976
Loa Loa (eye worm) hypothetical protein 0.0154 0.1582 0.1555
Echinococcus granulosus neuropeptide receptor 0.0066 0.0609 0.0609
Trichomonas vaginalis protein kinase atmrk1, putative 0.0075 0.0703 0.1976
Loa Loa (eye worm) haspin protein kinase 0.0416 0.4507 0.449
Brugia malayi hypothetical protein 0.0416 0.4507 0.449
Schistosoma mansoni zinc finger protein 0.0014 0.0032 0.0032
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0115 0.0659
Brugia malayi RE15519p 0.0066 0.0609 0.058
Schistosoma mansoni histamine h1 receptor 0.0066 0.0609 0.0609
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0041 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Loa Loa (eye worm) hypothetical protein 0.0066 0.0609 0.058
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0154 0.1582 1
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0212 0.0556
Brugia malayi larval opioid receptor 0.0066 0.0609 0.058
Schistosoma mansoni biogenic amine (5HT) receptor 0.0066 0.0609 0.0609
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0703 0.1976
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0604 0.0604
Echinococcus multilocularis neuropeptide Y receptor 0.0066 0.0609 0.0609
Plasmodium falciparum MO15-related protein kinase 0.0075 0.0703 0.5913

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 36 % Inhibition of human recombinant ATX at 100 uM after 16 hrs ChEMBL. 17257836
Inhibition (binding) = 36 % Inhibition of human recombinant ATX at 100 uM after 16 hrs ChEMBL. 17257836
Inhibition (binding) = 56 % Inhibition of human recombinant ATX at 10 uM after 16 hrs ChEMBL. 17257836
Inhibition (binding) = 56 % Inhibition of human recombinant ATX at 10 uM after 16 hrs ChEMBL. 17257836
Inhibition (binding) = 69 % Inhibition of human recombinant ATX at 100 uM after 16 hrs ChEMBL. 17257836
Inhibition (binding) = 69 % Inhibition of human recombinant ATX at 100 uM after 16 hrs ChEMBL. 17257836
Inhibition (binding) = 77 % Inhibition of human recombinant ATX at 1 uM after 16 hrs ChEMBL. 17257836
Inhibition (binding) = 77 % Inhibition of human recombinant ATX at 1 uM after 16 hrs ChEMBL. 17257836
Inhibition (binding) = 80 % Inhibition of human recombinant ATX at 10 uM after 16 hrs ChEMBL. 17257836
Inhibition (binding) = 80 % Inhibition of human recombinant ATX at 10 uM after 16 hrs ChEMBL. 17257836
Inhibition (binding) = 84 % Inhibition of human recombinant ATX at 1 uM after 16 hrs ChEMBL. 17257836
Inhibition (binding) = 84 % Inhibition of human recombinant ATX at 1 uM after 16 hrs ChEMBL. 17257836

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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