Detailed information for compound 442052

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 552.607 | Formula: C28H24N8O3S
  • H donors: 2 H acceptors: 7 LogP: 4.01 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: C[C@@H](c1ccccc1)Nc1nc(nc2c1cc(n2C)C(=O)NS(=O)(=O)c1ccccc1)n1cnc2c1cncc2
  • InChi: 1S/C28H24N8O3S/c1-18(19-9-5-3-6-10-19)31-25-21-15-23(27(37)34-40(38,39)20-11-7-4-8-12-20)35(2)26(21)33-28(32-25)36-17-30-22-13-14-29-16-24(22)36/h3-18H,1-2H3,(H,34,37)(H,31,32,33)/t18-/m0/s1
  • InChiKey: YMMDELZWPXRMGE-SFHVURJKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Janus kinase 3 Starlite/ChEMBL References
Homo sapiens Janus kinase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0012 0.0072 0.0139
Trypanosoma cruzi PAB1-binding protein , putative 0.001 0.0052 0.07
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0043
Brugia malayi SH2 domain containing protein 0.0006 0.0017 0.0105
Schistosoma mansoni serine/threonine protein kinase 0.0004 0.0001 0.0003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0017 0.0121 0.0121
Brugia malayi Inositol-1 0.0011 0.0061 0.037
Echinococcus granulosus tensin 0.0006 0.0017 0.0075
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0011 0.0061 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0043
Echinococcus multilocularis SH2 domain containing protein 7 0.0006 0.0017 0.0017
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0011 0.0068 0.0408
Loa Loa (eye worm) SH2 domain-containing protein 0.0006 0.0017 0.0105
Loa Loa (eye worm) hypothetical protein 0.0082 0.0729 0.4391
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Onchocerca volvulus Protein ultraspiracle homolog 0.0006 0.002 0.0271
Echinococcus multilocularis muscleblind protein 0.0182 0.1661 0.1661
Schistosoma mansoni tyrosine kinase 0.001 0.0057 0.0246
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Schistosoma mansoni serine/threonine RGC 0.0004 0.0001 0.0003
Trypanosoma brucei polo-like protein kinase 0.0036 0.0299 0.4096
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0006 0.0015 0.0031
Trichomonas vaginalis helicase, putative 0.0007 0.0025 0.0043
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0082 0.0729 0.4391
Echinococcus multilocularis lamin dm0 0.002 0.0146 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0006 0.002 0.0119
Loa Loa (eye worm) TK/FER protein kinase 0.0004 0.0001 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0106 0.1452
Plasmodium falciparum importin beta, putative 0.0008 0.0039 0.1378
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0004
Schistosoma mansoni ap endonuclease 0.0017 0.0121 0.0523
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0004 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0018 0.0134 0.0575
Mycobacterium ulcerans acyl-CoA synthetase 0.0011 0.0066 0.011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0729 0.3141
Brugia malayi hypothetical protein 0.0004 0.0001 0.0004
Echinococcus multilocularis dna polymerase kappa 0.0016 0.0106 0.0106
Brugia malayi Steroid receptor seven-up type 2 0.0006 0.002 0.0119
Echinococcus granulosus tyrosine protein kinase csk 0.0004 0.0001 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0011 0.0066 0.0903
Loa Loa (eye worm) hypothetical protein 0.0011 0.0066 0.04
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0043
Brugia malayi Protein kinase domain containing protein 0.001 0.0057 0.0345
Echinococcus granulosus nmda type glutamate receptor 0.0008 0.0037 0.0158
Schistosoma mansoni protein kinase 0.0004 0.0001 0.0003
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0007 0.0029 0.0126
Loa Loa (eye worm) hypothetical protein 0.001 0.005 0.0302
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0025 0.0197 0.0197
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0022 0.0168 0.2307
Echinococcus granulosus polycomb protein SCMH1 0.0022 0.0168 0.0725
Schistosoma mansoni vav2 0.0006 0.0017 0.0075
Echinococcus multilocularis ubiquitin specific protease 41 0.0011 0.0062 0.0062
Echinococcus multilocularis tyrosine protein kinase shark 0.001 0.0058 0.0058
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Trichomonas vaginalis glutathione reductase, putative 0.0012 0.0072 0.0127
Brugia malayi Variant SH3 domain containing protein 0.0006 0.0017 0.0105
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0017 0.0121 0.0208
Brugia malayi SH2 domain containing protein 0.001 0.0057 0.0345
Schistosoma mansoni hypothetical protein 0.009 0.0799 0.3441
Loa Loa (eye worm) hypothetical protein 0.0022 0.0168 0.1013
Entamoeba histolytica hypothetical protein 0.0005 0.0004 0.0075
Onchocerca volvulus 0.0006 0.0017 0.024
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0012 0.0072 0.0982
Loa Loa (eye worm) glutamate receptor 2 0.0006 0.0018 0.0111
Trypanosoma brucei unspecified product 0.0014 0.0094 0.1284
Loa Loa (eye worm) hypothetical protein 0.0011 0.0066 0.04
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.001 0.0057 0.0246
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0004
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0012 0.0072 0.0982
Mycobacterium ulcerans lipase LipD 0.0082 0.0729 0.129
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0016 0.0106 0.0188
Echinococcus granulosus histone acetyltransferase MYST2 0.0025 0.0197 0.0848
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0004 0.0001 0.0003
Onchocerca volvulus 0.0005 0.0012 0.0158
Brugia malayi RNA, U transporter 1 0.0024 0.0184 0.1109
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.056 0.2412
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0004 0.0001 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0011 0.0066 0.0903
Schistosoma mansoni cpg binding protein 0.0032 0.0258 0.1113
Loa Loa (eye worm) TK protein kinase 0.001 0.0057 0.0345
Schistosoma mansoni cpg binding protein 0.0032 0.0258 0.1113
Plasmodium vivax SET domain protein, putative 0.0007 0.0023 0.0302
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Loa Loa (eye worm) RGC/RGC protein kinase 0.0005 0.0012 0.0069
Echinococcus granulosus protein kinase 0.0004 0.0001 0.0003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0011 0.0066 0.011
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0025 0.0197 0.0848
Schistosoma mansoni hypothetical protein 0.0006 0.0017 0.0075
Brugia malayi cytoplasmic intermediate filament protein 0.0011 0.006 0.0361
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0006 0.002 0.0119
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0012 0.0072 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0106 0.1452
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0004 0.0001 0.0003
Schistosoma mansoni growth factor receptor-bound protein 0.0006 0.0017 0.0075
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0057 0.0345
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0072 0.0982
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0106 0.1452
Trypanosoma brucei protein kinase, putative 0.0004 0.0002 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0142 0.0858
Echinococcus granulosus tyrosine protein kinase shark 0.001 0.0058 0.0248
Echinococcus multilocularis tensin 0.0006 0.0017 0.0017
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0004 0.0001 0.0004
Leishmania major importin beta-1 subunit, putative 0.0007 0.0025 0.0328
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0013 0.0084 0.1142
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0006 0.002 0.002
Echinococcus multilocularis protein KINase family member (kin 25) 0.0004 0.0001 0.0001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0008 0.004 0.0073
Entamoeba histolytica protein kinase, putative 0.0004 0.0001 0.000000091136
Loa Loa (eye worm) TK/RYK protein kinase 0.0004 0.0001 0.0004
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Onchocerca volvulus 0.0022 0.0168 0.2307
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0004 0.0001 0.0003
Schistosoma mansoni tyrosine kinase 0.001 0.0057 0.0246
Echinococcus multilocularis tyrosine protein kinase csk 0.0004 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0024 0.018 0.0777
Schistosoma mansoni protein kinase 0.0004 0.0001 0.0003
Echinococcus multilocularis glutamate receptor 2 0.0007 0.0029 0.0029
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0011 0.0068 0.0292
Trypanosoma cruzi importin beta-1 subunit, putative 0.0007 0.0025 0.0328
Onchocerca volvulus 0.002 0.0146 0.1999
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.009 0.0799 0.4811
Loa Loa (eye worm) TK protein kinase 0.0004 0.0001 0.0004
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Brugia malayi Furin-like cysteine rich region family protein 0.0004 0.0001 0.0004
Brugia malayi hypothetical protein 0.0006 0.0019 0.0117
Schistosoma mansoni tensin 0.0006 0.0017 0.0075
Entamoeba histolytica protein kinase, putative 0.0004 0.0001 0.000000091136
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.001 0.0057 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0606 0.5624 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0043
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0009 0.0043 0.0256
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0011 0.0062 0.0108
Loa Loa (eye worm) SRC-1 0.001 0.0057 0.0345
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0006 0.0017 0.0105
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0012 0.0072 0.2542
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0004 0.0002 0.0015
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.001 0.0057 0.0245
Echinococcus multilocularis natriuretic peptide receptor 1 0.0004 0.0001 0.0001
Echinococcus multilocularis tyrosine protein kinase csk 0.0004 0.0001 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0057 0.0345
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0007 0.0029 0.0126
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0358 0.3301 0.6776
Schistosoma mansoni coup transcription factor 0.0006 0.002 0.0085
Brugia malayi Protein kinase domain containing protein 0.001 0.0057 0.0345
Brugia malayi AMP-binding enzyme family protein 0.0011 0.0066 0.04
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0011 0.0066 0.011
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0004 0.0001 0.0003
Schistosoma mansoni glutaminase 0.0171 0.156 0.672
Schistosoma mansoni tensin-related 0.0006 0.0017 0.0075
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0012 0.0072 0.0121
Echinococcus multilocularis tyrosine protein kinase Src64B 0.001 0.0057 0.0057
Echinococcus multilocularis survival motor neuron protein 1 0.0091 0.0807 0.0807
Onchocerca volvulus 0.0017 0.0116 0.1586
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0069 0.0941
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0299 0.0531
Brugia malayi Receptor family ligand binding region containing protein 0.0005 0.0012 0.0069
Brugia malayi hypothetical protein 0.0091 0.0807 0.4862
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0729 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0082 0.0729 0.3141
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0008 0.004 0.0063
Loa Loa (eye worm) hypothetical protein 0.0182 0.1661 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0072 0.0982
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0123 0.1107 0.1963
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0007 0.0023 0.0023
Echinococcus multilocularis epidermal growth factor receptor 0.0004 0.0001 0.0001
Loa Loa (eye worm) TK protein kinase 0.0004 0.0001 0.0004
Schistosoma mansoni hypothetical protein 0.0004 0.0001 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.004 0.0543
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0013 0.0084 0.1142
Onchocerca volvulus 0.0006 0.0017 0.024
Chlamydia trachomatis transglycolase/transpeptidase 0.0388 0.3583 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0068 0.0593 0.2556
Loa Loa (eye worm) RGC/RGC protein kinase 0.0005 0.0012 0.0069
Echinococcus granulosus survival motor neuron protein 1 0.0091 0.0807 0.3478
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0058 0.0505 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0007 0.0029 0.0029
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0091 0.0811 0.0811
Loa Loa (eye worm) hypothetical protein 0.0024 0.0181 0.109
Trypanosoma brucei beta lactamase 0.0068 0.0592 0.8115
Echinococcus granulosus SH2 domain containing protein 7 0.0006 0.0017 0.0075
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0068 0.0593 0.3574
Mycobacterium tuberculosis Probable esterase LipL 0.0082 0.0729 0.149
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0012 0.0072 0.0982
Trypanosoma cruzi PAB1-binding protein , putative 0.001 0.0052 0.07
Loa Loa (eye worm) hypothetical protein 0.0082 0.0729 0.4391
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0343
Schistosoma mansoni protein kinase 0.0004 0.0001 0.0003
Brugia malayi hypothetical protein 0.001 0.0052 0.0311
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0004 0.0002 0.0007
Schistosoma mansoni sex comb on midleg homolog 0.0022 0.0168 0.0725
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0006 0.002 0.002
Echinococcus multilocularis kinase suppressor of Ras 1 0.0004 0.0001 0.0001
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0004 0.0001 0.0003
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0011 0.0061 0.0835
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0017 0.0121 0.1657
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0729 1
Toxoplasma gondii LsmAD domain-containing protein 0.001 0.0052 0.07
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Schistosoma mansoni thyroid hormone receptor 0.0006 0.002 0.0085
Brugia malayi AMP-binding enzyme family protein 0.0011 0.0066 0.04
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0035 0.0064
Leishmania major GTP-binding protein, putative 0.0006 0.0019 0.0248
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0006 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0008 0.004 0.0239
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0028 0.0227 0.0396
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0006 0.0017 0.0017
Onchocerca volvulus 0.0018 0.0134 0.1831
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0006 0.002 0.0119
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0004 0.0001 0.0003
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.0121 0.0731
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0011 0.0068 0.0292
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Brugia malayi Guanylyl cyclase protein 23 0.0005 0.0012 0.0069
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0006 0.002 0.002
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0006 0.0017 0.0017
Schistosoma mansoni tensin 0.0006 0.0017 0.0075
Echinococcus granulosus natriuretic peptide receptor 1 0.0004 0.0001 0.0003
Trypanosoma brucei trypanothione reductase 0.0034 0.0282 0.3861
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0004 0.0001 0.0001
Brugia malayi glutaminase DH11.1 0.0171 0.156 0.9395
Loa Loa (eye worm) hypothetical protein 0.0007 0.0023 0.0136
Loa Loa (eye worm) TK/ALK protein kinase 0.0004 0.0001 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0007 0.0023 0.0097
Echinococcus granulosus tyrosine protein kinase Blk 0.001 0.0057 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0062 0.0108
Echinococcus granulosus histone lysine methyltransferase setb 0.0007 0.0023 0.0097
Mycobacterium ulcerans multidrug-transport integral membrane protein Mmr 0.0057 0.049 0.0863
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0006 0.0019 0.0248
Brugia malayi Uncoordinated protein 44 0.0004 0.0000000045982 0.000000027687
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0004 0.0001 0.0004
Brugia malayi mbt repeat family protein 0.0022 0.0168 0.1013
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0006 0.0019 0.0248
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0008 0.0037 0.0037
Brugia malayi glutathione reductase 0.0034 0.0282 0.1698
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0033 0.0033
Brugia malayi SH2 domain containing protein 0.0006 0.0017 0.0105
Echinococcus multilocularis SH2 motif 0.0006 0.0017 0.0017
Echinococcus multilocularis tyrosine protein kinase Blk 0.001 0.0057 0.0057
Trypanosoma brucei PAB1-binding protein , putative 0.001 0.0052 0.07
Loa Loa (eye worm) TK/FAK protein kinase 0.0004 0.0001 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.002 0.0119
Plasmodium vivax acyl-CoA synthetase, putative 0.0008 0.004 0.0537
Schistosoma mansoni protein kinase 0.0004 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0105
Echinococcus granulosus lamin dm0 0.002 0.0146 0.0628
Mycobacterium ulcerans multidrugs-transport integral membrane protein Mmr-like 0.0225 0.206 0.3658
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.001 0.0057 0.0057
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0006 0.0017 0.0075
Schistosoma mansoni DNA polymerase eta 0.001 0.0057 0.0245
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0006 0.002 0.0085
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0006 0.002 0.0085
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Echinococcus granulosus NCK adaptor protein 0.0006 0.0017 0.0075
Giardia lamblia Kinase, PLK 0.0036 0.0299 0.5915
Echinococcus granulosus tyrosine protein kinase Lyn 0.001 0.0058 0.0251
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0006 0.0019 0.0358
Schistosoma mansoni steroid hormone receptor ad4bp 0.0006 0.002 0.0085
Echinococcus granulosus protein tyrosine kinase 0.0004 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.0138 0.1254 0.5401
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0006 0.002 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0025 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0106 0.1452
Brugia malayi nuclear receptor NHR-88 0.0006 0.002 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0006 0.002 0.0119
Loa Loa (eye worm) TK/EPH protein kinase 0.0004 0.0001 0.0004
Entamoeba histolytica acyl-coA synthetase, putative 0.0011 0.0066 0.1304
Echinococcus granulosus dna polymerase kappa 0.0016 0.0106 0.0458
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.001 0.0057 0.0057
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0141 0.1275 0.2612
Brugia malayi ecdysteroid receptor 0.0006 0.002 0.0119
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0094 0.1284
Onchocerca volvulus 0.0024 0.0181 0.2483
Echinococcus multilocularis dna polymerase eta 0.001 0.0057 0.0057
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0011 0.0068 0.013
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0012 0.0072 0.0189
Echinococcus granulosus signal transduction protein lnk realted 0.0006 0.0017 0.0075
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0004 0.0000000045982 0.0000000045982
Echinococcus multilocularis tyrosine protein kinase 0.0004 0.0001 0.0001
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0006 0.0017 0.0017
Schistosoma mansoni tensin 0.0006 0.0017 0.0075
Schistosoma mansoni signal transduction protein lnk-related 0.0006 0.0017 0.0075
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0004 0.0002 0.0007
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Echinococcus granulosus tyrosine protein kinase ABL1 0.001 0.0057 0.0246
Onchocerca volvulus 0.0011 0.0066 0.0911
Plasmodium falciparum glutathione reductase 0.0012 0.0072 0.2542
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0068 0.0593 0.2556
Treponema pallidum penicillin-binding protein (pbp-1) 0.0388 0.3583 0.6368
Schistosoma mansoni ran 0.0006 0.0019 0.008
Loa Loa (eye worm) TK/FER protein kinase 0.0004 0.0001 0.0004
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0011 0.0062 0.0062
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0012 0.0072 0.0982
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0012 0.0072 0.0189
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0011 0.0061 0.0108
Schistosoma mansoni glutamate receptor AMPA 0.0006 0.0018 0.0079
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.001 0.0051 0.0083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0068 0.0593 0.2556
Echinococcus multilocularis tyrosine protein kinase Srms 0.001 0.0057 0.0057
Echinococcus granulosus tyrosine protein kinase Src42A 0.001 0.0057 0.0246
Brugia malayi Pre-SET motif family protein 0.0007 0.0023 0.0136
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0006 0.002 0.002
Leishmania major protein kinase, putative 0.0004 0.0002 0.0015
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0006 0.002 0.0119
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0011 0.0062 0.0265
Onchocerca volvulus 0.0006 0.0017 0.024
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0013 0.0084 0.1142
Brugia malayi CXXC zinc finger family protein 0.003 0.0242 0.1459
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0006 0.0017 0.0105
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0299 0.0531
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0043
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0033 0.0141
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Schistosoma mansoni sex comb on midleg homolog 0.0022 0.0168 0.0725
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0012 0.0072 0.0982
Echinococcus multilocularis tyrosine protein kinase csk 0.0004 0.0001 0.0001
Onchocerca volvulus 0.0004 0.0001 0.0008
Schistosoma mansoni protein kinase 0.0004 0.0002 0.0007
Echinococcus multilocularis L aminoadipate semialdehyde 0.0017 0.0116 0.0116
Onchocerca volvulus 0.0004 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0025 0.0197 0.1186
Loa Loa (eye worm) TK/FER protein kinase 0.0004 0.0001 0.0004
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0025 0.0197 0.1186
Echinococcus granulosus tyrosine protein kinase Fps85D 0.001 0.0057 0.0246
Schistosoma mansoni tensin-related 0.0006 0.0017 0.0075
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0011 0.0062 0.0062
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0022 0.0168 0.0725
Loa Loa (eye worm) TK protein kinase 0.0004 0.0001 0.0004
Schistosoma mansoni glutamate receptor kainate 0.0006 0.0018 0.0079
Trypanosoma brucei importin beta-1 subunit, putative 0.0008 0.0039 0.0532
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0371
Loa Loa (eye worm) hypothetical protein 0.0008 0.0039 0.0237
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0004 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0006 0.002 0.0119
Loa Loa (eye worm) glutaminase 2 0.0171 0.156 0.9395
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0011 0.0062 0.0371
Loa Loa (eye worm) TK/FER protein kinase 0.0004 0.0001 0.0004
Echinococcus multilocularis importin subunit beta 1 0.0008 0.0039 0.0039
Brugia malayi SH2 domain containing protein 0.0006 0.0017 0.0105
Schistosoma mansoni adapter molecule crk 0.0006 0.0017 0.0075
Echinococcus multilocularis geminin 0.0253 0.2322 0.2322
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0068 0.0592 0.1045
Echinococcus granulosus snurportin 1 0.009 0.0799 0.3441
Loa Loa (eye worm) hypothetical protein 0.0006 0.002 0.0119
Entamoeba histolytica SH2-protein kinase domain containing protein 0.001 0.0057 0.1122
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0011 0.0062 0.0837
Echinococcus multilocularis raf serine:threonine protein kinase 0.0004 0.0001 0.0001
Echinococcus granulosus importin subunit beta 1 0.0008 0.0039 0.017
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0011 0.0062 0.0265
Brugia malayi protein-tyrosine kinase 0.001 0.0057 0.0345
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0004 0.0001 0.0004
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0005 0.0004 0.0052
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Toxoplasma gondii NADPH-glutathione reductase 0.0012 0.0072 0.0982
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0006 0.0017 0.0075
Brugia malayi SH2 domain containing protein 0.0006 0.0017 0.0105
Loa Loa (eye worm) glutaminase 0.0171 0.156 0.9395
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0007 0.0023 0.0302
Brugia malayi SRC-1 0.001 0.0057 0.0345
Trichomonas vaginalis CAMK family protein kinase 0.0018 0.0128 0.0227
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0006 0.0017 0.0017
Echinococcus granulosus glutamate NMDA receptor subunit 0.0006 0.0018 0.0079
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0057 0.0057
Echinococcus multilocularis dnaJ subfamily B 0.0144 0.1303 0.1303
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0106 0.1452
Loa Loa (eye worm) hypothetical protein 0.0009 0.0047 0.0281
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0004 0.0001 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0025 0.0043
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0008 0.004 0.0099
Echinococcus multilocularis SAM and MBT domain containing protein 0.0022 0.0168 0.0168
Loa Loa (eye worm) TK/ACK protein kinase 0.0004 0.0001 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0006 0.002 0.0119
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0035 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0006 0.002 0.0119
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0006 0.0017 0.0017
Brugia malayi SH2 domain containing protein 0.0006 0.0017 0.0105
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0004 0.0002 0.0015
Onchocerca volvulus 0.0006 0.0017 0.024
Loa Loa (eye worm) TK protein kinase 0.0004 0.0001 0.0004
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0012 0.0072 0.0982
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0006 0.0017 0.0075
Entamoeba histolytica deoxycytidyl transferase, putative 0.001 0.0057 0.1116
Brugia malayi Muscleblind-like protein 0.0182 0.1661 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0006 0.002 0.002
Onchocerca volvulus 0.0006 0.002 0.0271
Echinococcus multilocularis SHC transforming protein 3 0.0006 0.0017 0.0017
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0013 0.0084 0.0361
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0006 0.002 0.0085
Brugia malayi Variant SH3 domain containing protein 0.0006 0.0017 0.0105
Schistosoma mansoni lipoxygenase 0.0024 0.018 0.0777
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0006 0.0017 0.0075
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0012 0.0072 0.0982
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0006 0.002 0.0271
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0011 0.0062 0.1208
Schistosoma mansoni protein kinase 0.0005 0.0012 0.005
Echinococcus granulosus suppressor of cytokine signaling 7 0.0006 0.0017 0.0075
Entamoeba histolytica ankyrin repeat protein 0.0004 0.0001 0.000000091136
Trichomonas vaginalis TKL family protein kinase 0.0004 0.0001 0.0000000081767
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0006 0.0017 0.0075
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0006 0.0017 0.0105
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0025 0.0043
Mycobacterium tuberculosis Conserved hypothetical protein 0.001 0.0057 0.0108
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.005 0.0215
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0003 0.0014
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0006 0.0017 0.0075
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0013 0.0084 0.0505
Brugia malayi nuclear hormone receptor 0.0006 0.002 0.0119
Echinococcus granulosus tyrosine protein kinase csk 0.0004 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0105
Schistosoma mansoni serine/threonine protein kinase 0.0004 0.0001 0.0003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0025 0.0043
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0004 0.0001 0.0003
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0358 0.3301 0.5866
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0878
Schistosoma mansoni myelin transcription factor 1 myt1 0.0025 0.0197 0.0848
Leishmania major phosphopantetheinyl transferase-like protein 0.0005 0.0004 0.0052
Loa Loa (eye worm) hypothetical protein 0.0082 0.0729 0.4391
Schistosoma mansoni lipoxygenase 0.0016 0.0114 0.0493
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0004 0.0001 0.0001
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.001 0.0057 0.0246
Echinococcus granulosus SH2 motif 0.0006 0.0017 0.0075
Brugia malayi photoreceptor-specific nuclear receptor 0.0006 0.002 0.0119
Brugia malayi AMP-binding enzyme family protein 0.0011 0.0066 0.04
Onchocerca volvulus 0.0006 0.0017 0.024
Loa Loa (eye worm) TK/INSR protein kinase 0.0004 0.0001 0.0004
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0004 0.0001 0.0001
Trypanosoma brucei unspecified product 0.0007 0.0027 0.0364
Onchocerca volvulus 0.001 0.0057 0.0785
Schistosoma mansoni nck2/grb4 0.0006 0.0017 0.0075
Brugia malayi Variant SH3 domain containing protein 0.0006 0.0017 0.0105
Schistosoma mansoni terminal deoxycytidyl transferase 0.001 0.0057 0.0245
Brugia malayi Protein kinase domain containing protein 0.001 0.0057 0.0345
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0012 0.0072 0.0311
Leishmania major 4-coumarate:coa ligase-like protein 0.0011 0.0066 0.0903
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0013 0.0084 0.0084
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0006 0.0019 0.0248
Loa Loa (eye worm) TK protein kinase 0.0004 0.0001 0.0004
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0006 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0105
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0017 0.0121 0.2393
Plasmodium vivax thioredoxin reductase, putative 0.0034 0.0282 0.3861
Echinococcus multilocularis tyrosine kinase 0.0005 0.0012 0.0012
Onchocerca volvulus 0.0004 0.0001 0.0008
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0004 0.0001 0.0000000081767
Echinococcus multilocularis 0.0006 0.0017 0.0017
Echinococcus granulosus retinal guanylyl cyclase 2 0.0004 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0091 0.0807 0.4862
Schistosoma mansoni intermediate filament proteins 0.002 0.0146 0.0628
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0106 0.1452
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0007 0.0023 0.0097
Trichomonas vaginalis CAMK family protein kinase 0.0018 0.0128 0.0227
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0057 0.0345
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0007 0.0023 0.0023
Mycobacterium tuberculosis Probable oxidoreductase 0.0012 0.0072 0.0139
Echinococcus granulosus tyrosine protein kinase HCK 0.0004 0.0001 0.0003
Leishmania major trypanothione reductase 0.0034 0.0282 0.3861
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0009 0.0043 0.0256
Mycobacterium leprae Probable lipase LipE 0.0082 0.0729 0.129
Loa Loa (eye worm) thioredoxin reductase 0.0034 0.0282 0.1698
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0043
Schistosoma mansoni thyroid hormone receptor 0.0006 0.002 0.0085
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0017 0.0116 0.0697
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0299 0.1288
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0028 0.0227 0.0457
Echinococcus granulosus epidermal growth factor receptor 0.0004 0.0001 0.0003
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0119 0.1075 0.22
Leishmania major hypothetical protein, conserved 0.001 0.0052 0.07
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0006 0.0017 0.0105
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0105
Plasmodium vivax glutathione reductase, putative 0.0034 0.0282 0.3861
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0011 0.0062 0.0837
Loa Loa (eye worm) TK protein kinase 0.0004 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0105
Echinococcus granulosus activin receptor type 0.0004 0.0002 0.0007
Onchocerca volvulus Serine\/threonine kinase homolog 0.0036 0.0299 0.4101
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0525 0.487 1
Echinococcus multilocularis insulin receptor 0.0004 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0007
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0011 0.0062 0.0837
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0012 0.0072 0.0189
Schistosoma mansoni ran 0.0006 0.0019 0.008
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0006 0.002 0.0119
Brugia malayi Glutamate receptor 1 precursor 0.0006 0.0018 0.0111
Loa Loa (eye worm) intermediate filament protein 0.002 0.0146 0.0878
Trichomonas vaginalis penicillin-binding protein, putative 0.0082 0.0729 0.1296
Giardia lamblia Kinase, NEK 0.0004 0.0001 0.0007
Entamoeba histolytica hypothetical protein 0.0017 0.0121 0.2387
Echinococcus granulosus hypothetical protein 0.0006 0.0017 0.0075
Plasmodium vivax importin-beta 2, putative 0.0008 0.0039 0.0532
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0011 0.0061 0.0835
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0004 0.0001 0.0001
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0082 0.0729 0.4391
Echinococcus granulosus intermediate filament protein 0.002 0.0146 0.0628
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0049 0.0294
Echinococcus granulosus raf serine:threonine protein kinase 0.0004 0.0001 0.0003
Echinococcus granulosus epidermal growth factor receptor 0.0004 0.0001 0.0003
Echinococcus multilocularis thioredoxin glutathione reductase 0.0034 0.0282 0.0282
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0043
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0011 0.0062 0.1208
Schistosoma mansoni hypothetical protein 0.0006 0.0017 0.0075
Plasmodium falciparum ataxin-2 like protein, putative 0.001 0.0052 0.1812
Echinococcus granulosus tyrosine kinase 0.001 0.0057 0.0246
Brugia malayi Intermediate filament tail domain containing protein 0.002 0.0146 0.0878
Loa Loa (eye worm) hypothetical protein 0.0008 0.004 0.0239
Loa Loa (eye worm) TK/EGFR protein kinase 0.0004 0.0001 0.0004
Trypanosoma cruzi polo-like protein kinase, putative 0.0036 0.0299 0.4096
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0004
Loa Loa (eye worm) MH2 domain-containing protein 0.0044 0.0371 0.2233
Mycobacterium ulcerans acyl-CoA synthetase 0.0011 0.0066 0.011
Brugia malayi Tyrosine-protein kinase PR2 0.0004 0.0001 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0025 0.0043
Toxoplasma gondii ABC1 family protein 0.0082 0.0729 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0006 0.0017 0.0075
Echinococcus granulosus N chimaerin 0.0006 0.0017 0.0075
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0004 0.0000000045982 0.000000019805
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0013 0.0084 0.0505
Schistosoma mansoni inositol monophosphatase 0.0011 0.0061 0.0265
Schistosoma mansoni lamin 0.002 0.0146 0.0628
Loa Loa (eye worm) hypothetical protein 0.0004 0 0.0002
Loa Loa (eye worm) hypothetical protein 0.0008 0.004 0.0239
Brugia malayi Variant SH3 domain containing protein 0.0006 0.0017 0.0105
Schistosoma mansoni hypothetical protein 0.0004 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0006 0.002 0.0119
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0057 0.0057
Echinococcus granulosus suppressor of cytokine signaling 6 0.0006 0.0017 0.0075
Plasmodium falciparum glutathione reductase 0.0034 0.0282 1
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0043
Schistosoma mansoni ankyrin 23/unc44 0.0004 0.0000000045982 0.000000019805
Loa Loa (eye worm) TK protein kinase 0.0004 0.0001 0.0004
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0011 0.0068 0.0921
Mycobacterium leprae conserved hypothetical protein 0.0082 0.0729 0.129
Echinococcus multilocularis N chimaerin 0.0006 0.0017 0.0017
Treponema pallidum penicillin-binding protein (pbp-2) 0.0606 0.5624 1
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0057 0.0345
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0072 0.0982
Echinococcus granulosus fibroblast growth factor receptor 4 0.0004 0.0001 0.0003
Echinococcus granulosus transcription factor Dp 1 0.0008 0.0032 0.0138
Schistosoma mansoni protein kinase 0.0004 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0345
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0105
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0068 0.0593 0.2556
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0039 0.0532
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0004 0.0001 0.0004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0006 0.002 0.0085
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0025 0.0043
Echinococcus multilocularis tensin 0.0006 0.0017 0.0017
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0082 0.0729 0.129
Brugia malayi bone morphogenetic protein type 1 receptor 0.0004 0.0001 0.0004
Trypanosoma cruzi DNA polymerase eta, putative 0.001 0.0057 0.0773
Echinococcus multilocularis growth factor receptor bound protein 2 0.0006 0.0017 0.0017
Echinococcus multilocularis nmda type glutamate receptor 0.0008 0.0037 0.0037
Giardia lamblia DINP protein human, muc B family 0.0012 0.0069 0.1359
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0017 0.0121 0.1657
Trichomonas vaginalis set domain proteins, putative 0.0048 0.0408 0.0725
Leishmania major DNA polymerase eta, putative 0.001 0.0057 0.0773
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0005 0.0004 0.0135
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0004 0.0002 0.0015
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0004 0.0001 0.0001
Echinococcus granulosus tyrosine protein kinase Src64B 0.001 0.0057 0.0246
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0299 0.0531
Onchocerca volvulus 0.001 0.0057 0.0785
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Echinococcus granulosus SH2 motif 0.0006 0.0017 0.0075
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0011 0.0068 0.0068
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0018 0.0134 0.0804
Loa Loa (eye worm) mbt repeat family protein 0.0022 0.0168 0.1013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0035 0.0064
Echinococcus granulosus dnaJ subfamily B 0.0144 0.1303 0.5613
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0006 0.0019 0.0248
Chlamydia trachomatis glutamine binding protein 0.0006 0.0015 0.0031
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.0387 0.3572 0.6348
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.002 0.0085
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0012 0.0072 0.0139
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0013 0.0084 0.0361
Schistosoma mansoni RAR-like nuclear receptor 0.0006 0.002 0.0085
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0006 0.0015 0.002
Echinococcus multilocularis epidermal growth factor receptor 0.0004 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0253 0.2322 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0006 0.002 0.0119
Trypanosoma brucei importin beta-1 subunit, putative 0.0008 0.0039 0.0532
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0058 0.0505 1
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Schistosoma mansoni suppressor of cytokine signaling 0.0006 0.0017 0.0075
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0011 0.0066 0.011
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0123 0.1107 0.2267
Treponema pallidum NADH oxidase 0.0012 0.0072 0.0121
Trypanosoma brucei unspecified product 0.0007 0.0027 0.0364
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0025 0.0043
Toxoplasma gondii thioredoxin reductase 0.0034 0.0282 0.3861
Plasmodium falciparum acyl-CoA synthetase 0.0008 0.004 0.1391
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0106 0.1452
Schistosoma mansoni inositol monophosphatase 0.0011 0.0061 0.0265
Echinococcus granulosus integrin linked protein kinase 0.0004 0.0001 0.0003
Brugia malayi tRNA modification GTPase TrmE family protein 0.0006 0.0017 0.0105
Echinococcus multilocularis tyrosine protein kinase Abl 0.001 0.0057 0.0057
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0006 0.0017 0.0017
Trichomonas vaginalis mercuric reductase, putative 0.0012 0.0072 0.0127
Trypanosoma cruzi trypanothione reductase, putative 0.0012 0.0072 0.0982
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0011 0.0068 0.0113
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0012 0.0069 0.0941
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0004 0.0001 0.0001
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0004 0.0001 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0039 0.0532
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0004 0.0001 0.0003
Echinococcus multilocularis protein kinase 0.0004 0.0001 0.0001
Schistosoma mansoni cellular tumor antigen P53 0.0024 0.0181 0.078
Schistosoma mansoni tyrosine kinase 0.001 0.0057 0.0246
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0058 0.0505 0.0897
Brugia malayi RhoGAP domain containing protein 0.0006 0.0017 0.0105
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0121 0.1657
Schistosoma mansoni survival motor neuron protein 0.0018 0.0134 0.0575
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0068 0.0593 0.0593
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0007 0.0023 0.0097
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0006 0.002 0.0085
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Mycobacterium tuberculosis Probable lipase LipD 0.0082 0.0729 0.149
Echinococcus granulosus dna polymerase eta 0.001 0.0057 0.0245
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0012 0.0072 0.0982
Loa Loa (eye worm) hypothetical protein 0.0008 0.004 0.0242
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0058 0.0505 0.0897
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0006 0.002 0.0119
Loa Loa (eye worm) histone methyltransferase 0.001 0.005 0.0301
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0012 0.0069 0.0133
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0004 0.0001 0.0001
Giardia lamblia Fructose-bisphosphate aldolase 0.0058 0.0505 1
Onchocerca volvulus 0.001 0.0057 0.0785
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0057 0.0246
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0006 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0006 0.002 0.0119
Schistosoma mansoni lamin 0.002 0.0146 0.0628
Echinococcus multilocularis protein tyrosine kinase 0.0004 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.004 0.0239
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0004 0 0.0001
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0004 0.0001 0.0008
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0606 0.5624 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0006 0.0017 0.0017
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0004 0.0001 0.0004
Schistosoma mansoni protein tyrosine kinase 0.0004 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0006 0.002 0.0119
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0006 0.002 0.0085
Echinococcus multilocularis glutamate receptor 2 0.0006 0.0018 0.0018
Trichomonas vaginalis glutaminase, putative 0.0171 0.156 0.2773
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0004 0.0001 0.0001
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0012 0.0072 0.0121
Onchocerca volvulus 0.0082 0.0729 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0004
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0121 0.0215
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0006 0.0014 0.0062
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0006 0.0018 0.0018
Brugia malayi hypothetical protein 0.0006 0.0017 0.0105
Echinococcus multilocularis SH2 motif 0.0006 0.0017 0.0017
Loa Loa (eye worm) TK protein kinase 0.0004 0.0001 0.0004
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0243 0.2233 0.3965
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0057 0.0057
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.002 0.0146 0.0878
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0007 0.0025 0.0043
Chlamydia trachomatis transglycolase/transpeptidase 0.0242 0.2221 0.6195
Entamoeba histolytica acyl-CoA synthetase, putative 0.0011 0.0066 0.1304
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0011 0.0061 0.0159
Echinococcus multilocularis activin receptor type 0.0004 0.0002 0.0002
Mycobacterium tuberculosis Conserved protein 0.0082 0.0729 0.149
Trichomonas vaginalis TKL family protein kinase 0.0004 0.0001 0.0000000081767
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0006 0.002 0.0119
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0004 0.0001 0.0004
Onchocerca volvulus 0.0004 0.0001 0.0008
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0005 0.0004 0.0052
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0012 0.0072 0.0121
Loa Loa (eye worm) glutathione reductase 0.0034 0.0282 0.1698
Leishmania major DNA polymerase kappa, putative 0.0012 0.0069 0.0941
Loa Loa (eye worm) hypothetical protein 0.0082 0.0729 0.4391
Entamoeba histolytica protein kinase domain containing protein 0.0004 0.0002 0.0022
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0004 0.0001 0.0003
Treponema pallidum penicillin-binding protein (pbp-3) 0.0387 0.3572 0.6348
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Plasmodium vivax ataxin-2 like protein, putative 0.001 0.0052 0.07
Trichomonas vaginalis penicillin-binding protein, putative 0.0082 0.0729 0.1296
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0057 0.0246
Brugia malayi SH2 domain containing protein 0.0006 0.0017 0.0105
Loa Loa (eye worm) protein kinase domain-containing protein 0.0004 0.0001 0.0004
Schistosoma mansoni hypothetical protein 0.0144 0.1303 0.5613
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0105
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0091 0.0811 0.3491
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0106 0.0182
Entamoeba histolytica hypothetical protein 0.0017 0.0121 0.2387
Echinococcus multilocularis muscleblind protein 1 0.0182 0.1661 0.1661
Schistosoma mansoni retinoic acid receptor RXR 0.0006 0.002 0.0085
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0282 0.3861
Onchocerca volvulus Tyrosine kinase homolog 0.0004 0.0001 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0106 0.1452
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0004 0.0001 0.0004
Schistosoma mansoni protein kinase 0.0004 0.0001 0.0003
Brugia malayi STAT protein, DNA binding domain containing protein 0.0006 0.0017 0.0105
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0006 0.002 0.0085
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0011 0.0066 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0106 0.1452
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0006 0.002 0.0119
Entamoeba histolytica Ran family GTPase 0.0006 0.0019 0.0358
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0035 0.0064
Echinococcus multilocularis tyrosine protein kinase Fgr 0.001 0.0057 0.0057
Entamoeba histolytica hypothetical protein 0.0017 0.0121 0.2387
Echinococcus multilocularis ecdysone induced protein 78C 0.0006 0.002 0.002
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0012 0.0072 0.0434
Echinococcus granulosus ephrin type A receptor 4 A 0.0004 0.0001 0.0003
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0006 0.0019 0.0112
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0011 0.0068 0.0113
Onchocerca volvulus 0.003 0.0242 0.3323
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0121 0.0215
Trichomonas vaginalis importin beta-1, putative 0.0007 0.0025 0.0043
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0042 0.0355 0.2135
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0006 0.0017 0.0075
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.0121 0.0731
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.001 0.0057 0.0057
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0036 0.0299 0.1801
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0243 0.2233 0.3965
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0057 0.0345
Loa Loa (eye worm) TK protein kinase 0.0004 0.0001 0.0004
Echinococcus granulosus inositol monophosphatase 1 0.0011 0.0061 0.0265
Schistosoma mansoni serine/threonine protein kinase 0.0004 0.0001 0.0003
Brugia malayi SH2 domain containing protein 0.001 0.0057 0.0345
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0013 0.0084 0.1142
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0006 0.0019 0.0112
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0004
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0004 0.0001 0.0003
Brugia malayi serine/threonine-protein kinase plk-2 0.0036 0.0299 0.1801
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0057 0.0345
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0105
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0004 0.0001 0.0004
Schistosoma mansoni growth factor receptor-bound protein 0.0006 0.0017 0.0075
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0082 0.0729 0.149
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.004 0.0543
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0058 0.0505 0.0897
Schistosoma mansoni hypothetical protein 0.0017 0.0121 0.0521
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0082 0.0729 0.149
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0729 0.1296
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0058 0.0505 0.0897
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0011 0.0066 0.011
Echinococcus multilocularis glutamate receptor 2 0.0005 0.0008 0.0008
Mycobacterium ulcerans hypothetical protein 0.0011 0.0066 0.011
Loa Loa (eye worm) RGC/RGC protein kinase 0.0005 0.0012 0.0069
Brugia malayi beta-lactamase family protein 0.0082 0.0729 0.4391
Echinococcus granulosus c src tyrosine kinase 0.001 0.0057 0.0246
Echinococcus granulosus ubiquitin specific protease 41 0.0011 0.0062 0.0265
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0057 0.0345
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0025 0.0043
Brugia malayi Protein kinase domain containing protein 0.001 0.0057 0.0345
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0007 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0006 0.002 0.0119
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0004 0.0002 0.0002
Mycobacterium ulcerans lipoprotein LpqF 0.0068 0.0592 0.1045
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0006 0.0017 0.0105
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0011 0.0062 0.0108
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0106 0.1452
Echinococcus multilocularis protein kinase 0.0004 0.0001 0.0001
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0007 0.0029 0.0029
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0012 0.0072 0.0982
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0729 0.3141
Echinococcus multilocularis tumor protein p63 0.0161 0.1465 0.1465
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0004 0.0001 0.0001
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0011 0.0062 0.0837
Echinococcus multilocularis c src tyrosine kinase 0.001 0.0057 0.0057
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0006 0.002 0.0085
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0012 0.0072 0.0982
Echinococcus multilocularis cpg binding protein 0.0032 0.0258 0.0258
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0243 0.2233 0.458
Echinococcus multilocularis histone acetyltransferase MYST2 0.0025 0.0197 0.0197
Mycobacterium tuberculosis Probable lipase LipE 0.0082 0.0729 0.149
Echinococcus granulosus thioredoxin glutathione reductase 0.0034 0.0282 0.1214
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.001 0.0051 0.0096
Schistosoma mansoni protein kinase 0.0004 0.0002 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0299 0.0531
Schistosoma mansoni nuclear hormone receptor 0.0006 0.002 0.0085
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Echinococcus multilocularis snurportin 1 0.009 0.0799 0.0799
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0299 0.0531
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0005 0.0003 0.0032
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0606 0.5624 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0116 0.0697
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0106 0.1452
Onchocerca volvulus 0.0006 0.0017 0.024
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0004 0.0001 0.0001
Schistosoma mansoni tyrosine kinase 0.0005 0.0012 0.005
Echinococcus granulosus retinal guanylyl cyclase 2 0.0004 0.0001 0.0003
Brugia malayi beta-lactamase 0.0082 0.0729 0.4391
Echinococcus granulosus GTP binding nuclear protein Ran 0.0006 0.0019 0.008
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0121 0.1657
Echinococcus granulosus tyrosine protein kinase 0.0004 0.0001 0.0003
Onchocerca volvulus 0.0004 0.0001 0.0008
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0011 0.0062 0.0265
Loa Loa (eye worm) serine/threonine protein kinase 0.0004 0.0001 0.0004
Brugia malayi ephrin receptor 1 precursor 0.0004 0.0001 0.0004
Treponema pallidum fructose-bisphosphate aldolase 0.0058 0.0505 0.0891
Schistosoma mansoni ATP-binding cassette transporter 0.0006 0.0018 0.0079
Brugia malayi Importin beta-1 subunit 0.0008 0.0039 0.0237
Loa Loa (eye worm) hypothetical protein 0.0008 0.004 0.0239
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0729 1
Brugia malayi intermediate filament protein 0.002 0.0146 0.0878
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0068 0.0593 0.2556
Loa Loa (eye worm) TK/ABL protein kinase 0.001 0.0057 0.0345
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0011 0.006 0.0361
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0028 0.0227 0.0396
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0006 0.002 0.0119
Schistosoma mansoni ephrin receptor 0.0004 0.0001 0.0003
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0017 0.0116 0.0498
Schistosoma mansoni shc transforming protein 0.0006 0.0017 0.0075
Loa Loa (eye worm) hypothetical protein 0.0006 0.002 0.0119
Brugia malayi mbt repeat family protein 0.0022 0.0168 0.1013
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0106 0.1452
Trypanosoma brucei DNA polymerase kappa, putative 0.0008 0.0039 0.0532
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0057 0.0345
Mycobacterium ulcerans hypothetical protein 0.0082 0.0729 0.129
Loa Loa (eye worm) inositol-1 0.0011 0.0061 0.037
Brugia malayi MH2 domain containing protein 0.0044 0.0371 0.2233
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0017 0.0121 0.0327
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0012 0.0072 0.0982
Onchocerca volvulus 0.001 0.0057 0.0785
Trichomonas vaginalis ran, putative 0.0006 0.0019 0.0032
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0007 0.0029 0.0126
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0036 0.0299 0.0299
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0006 0.002 0.0085
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0006 0.002 0.002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0058 0.0505 0.0897
Echinococcus granulosus SH2 domain containing adapter protein F 0.0006 0.0017 0.0075
Echinococcus granulosus tyrosine kinase 0.0005 0.0012 0.005
Plasmodium falciparum ataxin-2 like protein, putative 0.001 0.0052 0.1812
Schistosoma mansoni transcription factor LCR-F1 0.0017 0.0121 0.0521
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.001 0.0057 0.0246
Echinococcus granulosus geminin 0.0253 0.2322 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0004 0.0001 0.0003
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0012 0.0072 0.0982
Onchocerca volvulus 0.0082 0.0729 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0005 0.0012 0.0158
Schistosoma mansoni glutamate receptor NMDA 0.0007 0.0029 0.0126
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0105
Plasmodium falciparum protein kinase, putative 0.0004 0.0002 0.0039
Onchocerca volvulus 0.0004 0.0001 0.0008
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0106 0.0182
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0017 0.0105
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0006 0.0017 0.0075
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0004 0.0001 0.0001
Echinococcus granulosus retinal guanylyl cyclase 2 0.0004 0.0001 0.0003
Mycobacterium tuberculosis Conserved protein 0.0082 0.0729 0.149
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0242 0.1459
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0121 0.4292
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0012 0.0072 0.0072
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0011 0.0062 0.0265
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0057 0.0345
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Echinococcus granulosus kinase suppressor of Ras 1 0.0004 0.0001 0.0003
Entamoeba histolytica hypothetical protein 0.0017 0.0121 0.2387
Brugia malayi ImpB/MucB/SamB family protein 0.001 0.0057 0.0343
Echinococcus granulosus tyrosine kinase 0.001 0.0057 0.0246
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0058 0.0505 0.0897
Brugia malayi Immunoglobulin I-set domain containing protein 0.0004 0.0001 0.0004
Echinococcus granulosus SHC transforming protein 3 0.0006 0.0017 0.0075
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0068 0.0593 0.3574
Mycobacterium tuberculosis Conserved protein 0.0082 0.0729 0.149
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0012 0.0072 0.2542
Echinococcus granulosus nuclear factor of activated T cells 5 0.0021 0.0161 0.0695
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0011 0.0066 0.011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0006 0.002 0.0119
Onchocerca volvulus 0.0007 0.0023 0.031
Loa Loa (eye worm) transcription factor SMAD2 0.0044 0.0371 0.2233
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0082 0.0729 0.4391
Echinococcus multilocularis signal transduction protein lnk realted 0.0006 0.0017 0.0017
Brugia malayi hypothetical protein 0.001 0.0057 0.0345
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0011 0.0061 0.0835
Echinococcus granulosus tyrosine protein kinase csk 0.0004 0.0001 0.0003
Trichomonas vaginalis esterase, putative 0.0082 0.0729 0.1296
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0013 0.0084 0.1649
Echinococcus granulosus tyrosine protein kinase Btk29A 0.001 0.0057 0.0246
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0729 0.1296
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0017 0.0121 0.1657
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0358 0.3301 0.5866
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Brugia malayi Glutamate receptor 2 precursor 0.0006 0.0018 0.0111
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0012 0.0072 0.0982
Echinococcus multilocularis heat shock protein 70 0.0004 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0058 0.0505 0.0897
Echinococcus granulosus growth factor receptor bound protein 2 0.0006 0.0017 0.0075
Onchocerca volvulus 0.001 0.0057 0.0785
Echinococcus multilocularis tyrosine protein kinase pr2 0.0004 0.0001 0.0001
Trypanosoma cruzi polo-like protein kinase, putative 0.0036 0.0299 0.4096
Echinococcus granulosus tyrosine protein kinase Src42A 0.0006 0.0017 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0004 0.0001 0.0000000081767
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0006 0.0017 0.0075
Echinococcus multilocularis SH2 motif 0.0006 0.0017 0.0017
Onchocerca volvulus 0.0048 0.0408 0.5601
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0004 0.0001 0.0004
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0007 0.0029 0.0126
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0106 0.1452
Echinococcus multilocularis tyrosine protein kinase Src42A 0.001 0.0057 0.0057
Echinococcus granulosus lamin 0.002 0.0146 0.0628
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Schistosoma mansoni importin beta-1 0.0008 0.0039 0.017
Trichomonas vaginalis DNA polymerase eta, putative 0.0016 0.0106 0.0188
Echinococcus granulosus expressed conserved protein 0.0006 0.0017 0.0075
Brugia malayi cytokine inducible SH2-containing protein 5 0.0006 0.0017 0.0105
Loa Loa (eye worm) TK/DDR protein kinase 0.0004 0.0001 0.0004
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0004 0.0001 0.0004
Treponema pallidum exodeoxyribonuclease (exoA) 0.0017 0.0121 0.0208
Loa Loa (eye worm) SH2 domain-containing protein 0.0006 0.0017 0.0105
Loa Loa (eye worm) TK/FER protein kinase 0.0004 0.0001 0.0004
Echinococcus granulosus ecdysone induced protein 78C 0.0006 0.002 0.0085
Onchocerca volvulus 0.002 0.0146 0.1999
Echinococcus multilocularis beta LACTamase domain containing family member 0.0082 0.0729 0.0729
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.001 0.0057 0.0057
Schistosoma mansoni protein kinase 0.0004 0.0002 0.0007
Echinococcus granulosus tyrosine protein kinase pr2 0.0004 0.0001 0.0003
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0057 0.0057
Onchocerca volvulus 0.001 0.0057 0.0785
Onchocerca volvulus 0.0082 0.0729 1
Giardia lamblia Protein 21.1 0.0004 0.0001 0.000000091136
Brugia malayi Thioredoxin reductase 0.0034 0.0282 0.1698
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0299 0.0531
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0024 0.018 0.018
Brugia malayi Pre-SET motif family protein 0.0042 0.0355 0.2135
Mycobacterium ulcerans glutaminase 0.0171 0.156 0.2768
Entamoeba histolytica SH2 domain containing protein 0.0006 0.0017 0.0335
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.001 0.0057 0.0057
Schistosoma mansoni ephrin receptor 0.0004 0.0001 0.0003
Brugia malayi Raf kinase 0.0004 0.0001 0.0004
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0011 0.0061 0.0101
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0021 0.0161 0.0161
Mycobacterium tuberculosis Probable hydrolase 0.0082 0.0729 0.149
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0105
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0004 0.0001 0.0003
Brugia malayi C-terminal src kinase protein 1 0.0004 0.0001 0.0004
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0082 0.0729 0.149
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0057 0.0345
Schistosoma mansoni kinase 0.0018 0.0133 0.0572
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0011 0.0061 0.1206
Echinococcus multilocularis tyrosine protein kinase HCK 0.0004 0.0001 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0005 0.0004 0.0052
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0006 0.002 0.0119
Echinococcus granulosus tumor protein p63 0.0161 0.1465 0.6311
Schistosoma mansoni SH2A 0.0006 0.0017 0.0075
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0006 0.0015 0.0023
Echinococcus granulosus insulin receptor 0.0004 0.0001 0.0003
Loa Loa (eye worm) TK/ROR protein kinase 0.0004 0.0001 0.0004
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0033 0.0033
Loa Loa (eye worm) glutamate receptor 1 0.0006 0.0018 0.0111
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0249 0.2284 0.4685
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0123 0.1107 0.1963
Entamoeba histolytica acyl-CoA synthetase, putative 0.0011 0.0066 0.1304
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0119 0.1075 0.1905
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.001 0.0057 0.0343
Echinococcus multilocularis activated cdc42 kinase 1 0.0004 0.0001 0.0001
Entamoeba histolytica protein kinase, putative 0.0006 0.0019 0.0356
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0006 0.0017 0.0017
Trypanosoma brucei DNA polymerase eta, putative 0.001 0.0057 0.0773
Plasmodium falciparum thioredoxin reductase 0.0012 0.0072 0.2542
Brugia malayi Immunoglobulin I-set domain containing protein 0.0004 0.0001 0.0004
Brugia malayi steroid hormone receptor 0.0006 0.002 0.0119
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0017 0.0121 0.0521
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Loa Loa (eye worm) TK/Met protein kinase 0.0004 0.0001 0.0004
Brugia malayi Death domain containing protein 0.0004 0.0000000045982 0.000000027687
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0106 0.1452
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0033 0.0141
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0004
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0006 0.002 0.0119
Schistosoma mansoni glutamate receptor kainate 0.0006 0.0018 0.0079
Mycobacterium ulcerans esterase/lipase LipP 0.0082 0.0729 0.129
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0034 0.0282 0.057
Brugia malayi beta-lactamase family protein 0.0082 0.0729 0.4391
Echinococcus multilocularis tyrosine protein kinase csk 0.0004 0.0001 0.0001
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0004 0.0001 0.0004
Brugia malayi Tyrosine-protein kinase abl-1 0.001 0.0057 0.0345
Echinococcus multilocularis integrin linked protein kinase 0.0004 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0004
Schistosoma mansoni glutamate receptor kainate 0.0006 0.0018 0.0079
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0012 0.0072 0.0311
Mycobacterium ulcerans beta-lactamase 0.0082 0.0729 0.129
Schistosoma mansoni GTPase activating protein 0.0006 0.0017 0.0075
Onchocerca volvulus 0.0004 0.0001 0.0008
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0004 0.0001 0.0003
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0004 0.0002 0.0002
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0006 0.002 0.0085
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0006 0.002 0.0085
Onchocerca volvulus 0.0004 0.0001 0.0008
Leishmania major hypothetical protein, conserved 0.0082 0.0729 1
Schistosoma mansoni protein kinase 0.0004 0.0001 0.0003
Echinococcus granulosus glutamate receptor 2 0.0007 0.0029 0.0126
Brugia malayi Tensin 0.0006 0.0017 0.0105
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0007 0.0029 0.0029
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Echinococcus multilocularis NCK adaptor protein 0.0006 0.0017 0.0017
Loa Loa (eye worm) steroid hormone receptor 0.0006 0.002 0.0119
Loa Loa (eye worm) TK/CSK protein kinase 0.0004 0.0001 0.0004
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0011 0.0061 0.0835
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0007 0.0025 0.0043
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0012 0.0072 0.0121
Echinococcus granulosus Ankyrin 0.0004 0 0.0001
Schistosoma mansoni tyrosine kinase 0.001 0.0057 0.0246
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0006 0.0019 0.0356
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0017 0.0121 0.024
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0033 0.0141
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.0121 0.0523
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0004 0.0001 0.0004
Echinococcus multilocularis polycomb protein SCMH1 0.0022 0.0168 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0006 0.002 0.0119
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Schistosoma mansoni ap endonuclease 0.0017 0.0121 0.0523
Entamoeba histolytica serine/threonine protein kinase, putative 0.0036 0.0299 0.5915
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0004 0.0001 0.0004
Plasmodium falciparum thioredoxin reductase 0.0034 0.0282 1
Echinococcus multilocularis tyrosine kinase 0.001 0.0057 0.0057
Schistosoma mansoni suppressor of cytokine signaling 0.0006 0.0017 0.0075
Schistosoma mansoni hypothetical protein 0.0253 0.2322 1
Schistosoma mansoni cpg binding protein 0.003 0.0242 0.1044
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0025 0.0043
Schistosoma mansoni tyrosine kinase 0.001 0.0057 0.0246
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0007 0.0023 0.0097
Loa Loa (eye worm) hypothetical protein 0.0005 0.0012 0.0069
Schistosoma mansoni tyrosine kinase 0.0004 0.0001 0.0003
Echinococcus multilocularis ephrin type A receptor 4 A 0.0004 0.0001 0.0001
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0006 0.0017 0.0105
Echinococcus granulosus cytoplasmic intermediate filament protein 0.001 0.005 0.0216
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0011 0.0066 0.0127
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0009 0.0047 0.0281
Echinococcus granulosus tyrosine protein kinase Srms 0.001 0.0057 0.0246
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0036 0.0299 0.4096
Trypanosoma brucei hypothetical protein, conserved 0.0082 0.0729 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.001 0.0057 0.0057
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0006 0.002 0.0085
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0057 0.0246
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.0388 0.3583 1
Brugia malayi SH2 domain containing protein 0.0006 0.0017 0.0105
Toxoplasma gondii HEAT repeat-containing protein 0.0008 0.0039 0.0532
Brugia malayi polk-prov protein 0.0008 0.004 0.0242
Loa Loa (eye worm) TK/FER protein kinase 0.0004 0.0001 0.0004
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0006 0.0017 0.024
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.001 0.0057 0.0057
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0011 0.006 0.0364
Loa Loa (eye worm) TK/FER protein kinase 0.0004 0.0001 0.0004
Echinococcus multilocularis receptor type guanylyl cyclase 0.0005 0.0012 0.0012
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0006 0.0019 0.0248
Echinococcus granulosus FTZ F1 alpha 0.0006 0.002 0.0085
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0072 0.0982
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0105
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0105
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0311
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0006 0.0019 0.0641
Echinococcus multilocularis lamin 0.002 0.0146 0.0146
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0004 0.0001 0.0003
Loa Loa (eye worm) RGC/RGC protein kinase 0.0004 0.0001 0.0004
Onchocerca volvulus Bile acid receptor homolog 0.0006 0.002 0.0271
Brugia malayi hypothetical protein 0.0004 0.0001 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0072 0.0982
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0004 0.0002 0.0015
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Echinococcus granulosus activated cdc42 kinase 1 0.0004 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0066 0.04
Brugia malayi ImpB/MucB/SamB family protein 0.001 0.0057 0.0343
Loa Loa (eye worm) SH2 domain-containing protein 0.0006 0.0017 0.0105
Loa Loa (eye worm) beta-lactamase 0.0082 0.0729 0.4391
Entamoeba histolytica hypothetical protein 0.0007 0.0025 0.0474
Loa Loa (eye worm) STAT protein 0.0006 0.0017 0.0105
Brugia malayi integrin-linked kinase 0.0004 0.0001 0.0004
Schistosoma mansoni glutamate receptor AMPA 0.0006 0.0018 0.0079
Schistosoma mansoni tyrosine kinase 0.0005 0.0012 0.005
Echinococcus granulosus muscleblind protein 0.0182 0.1661 0.7153
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0036 0.0299 0.1288
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0004 0.0001 0.0003
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0017 0.0121 0.2393
Schistosoma mansoni tyrosine kinase 0.001 0.0058 0.0248
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0004
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0004 0.0001 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0072 0.0982
Loa Loa (eye worm) hypothetical protein 0.0082 0.0729 0.4391
Echinococcus multilocularis transfer RNA-Thr 0.0004 0.0001 0.0001
Echinococcus multilocularis transcription factor Dp 1 0.0008 0.0032 0.0032
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.001 0.005 0.005
Echinococcus granulosus L aminoadipate semialdehyde 0.0017 0.0116 0.0498
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0011 0.0066 0.0127
Echinococcus multilocularis inositol monophosphatase 1 0.0011 0.0061 0.0061
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0068 0.0592 0.1207
Echinococcus granulosus SAM and MBT domain containing protein 0.0022 0.0168 0.0725
Echinococcus multilocularis musashi 0.002 0.0146 0.0146
Echinococcus granulosus glutamate receptor 2 0.0005 0.0008 0.0035
Echinococcus multilocularis FL cytokine receptor 0.0004 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0058 0.0505 0.0897
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0105
Trichomonas vaginalis inositol monophosphatase, putative 0.0011 0.0061 0.0108
Echinococcus multilocularis FTZ F1 alpha 0.0006 0.002 0.002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0006 0.002 0.0119
Brugia malayi Sex muscle abnormal protein 5 0.0006 0.0017 0.0105
Mycobacterium ulcerans acyl-CoA synthetase 0.0011 0.0066 0.011
Echinococcus granulosus receptor type guanylyl cyclase 0.0005 0.0012 0.005
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0006 0.002 0.0119
Loa Loa (eye worm) MBCTL1 0.0025 0.0197 0.1186
Echinococcus granulosus cpg binding protein 0.0032 0.0258 0.1113
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0496 0.6801
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0006 0.0019 0.0019
Trichomonas vaginalis TKL family protein kinase 0.0004 0.0001 0.0000000081767
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.001 0.0057 0.0245
Brugia malayi Protein kinase domain containing protein 0.001 0.0057 0.0345
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0729 0.1296
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0005 0.0004 0.0052
Schistosoma mansoni tyrosine protein kinase 0.0004 0.0001 0.0003
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0011 0.0061 0.0835
Toxoplasma gondii exonuclease III APE 0.0017 0.0121 0.1657
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0299 0.0531
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0141 0.1275 0.2262
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0106 0.1452
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0006 0.002 0.002
Brugia malayi Protein kinase domain containing protein 0.0004 0.0001 0.0004
Brugia malayi hypothetical protein 0.0017 0.0121 0.0729
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0068 0.0593 0.0593
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0006 0.002 0.0119
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0006 0.0017 0.024
Loa Loa (eye worm) hypothetical protein 0.0182 0.1661 1
Echinococcus granulosus activated cdc42 kinase 1 0.0004 0.0001 0.0003
Schistosoma mansoni glutamate receptor NMDA 0.0006 0.0018 0.0079
Giardia lamblia NADH oxidase lateral transfer candidate 0.0012 0.0072 0.1418
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0004 0.0001 0.0003

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 143 nM Inhibition of JAK3 by kinase-Glo luminescent assay ChEMBL. 17189692
IC50 (binding) = 143 nM Inhibition of JAK3 by kinase-Glo luminescent assay ChEMBL. 17189692
IC50 (binding) = 359 nM Inhibition of JAK2 by kinase-Glo luminescent assay ChEMBL. 17189692
IC50 (binding) = 359 nM Inhibition of JAK2 by kinase-Glo luminescent assay ChEMBL. 17189692

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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