Detailed information for compound 460303

Basic information

Technical information
  • TDR Targets ID: 460303
  • Name: 1-[(4R)-4-[3-(dimethylamino)propyl]-2-(2-fluo ro-5-methylphenyl)-4-phenyl-3H-pyrazol-5-yl]e thanone
  • MW: 381.486 | Formula: C23H28FN3O
  • H donors: 0 H acceptors: 1 LogP: 4.13 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCC[C@]1(CN(N=C1C(=O)C)c1cc(C)ccc1F)c1ccccc1)C
  • InChi: 1S/C23H28FN3O/c1-17-11-12-20(24)21(15-17)27-16-23(13-8-14-26(3)4,22(25-27)18(2)28)19-9-6-5-7-10-19/h5-7,9-12,15H,8,13-14,16H2,1-4H3/t23-/m0/s1
  • InChiKey: FTEPMVFWUZEGMB-QHCPKHFHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(4R)-4-[3-(dimethylamino)propyl]-2-(2-fluoro-5-methyl-phenyl)-4-phenyl-3H-pyrazol-5-yl]ethanone
  • 1-[(4R)-4-[3-(dimethylamino)propyl]-1-(2-fluoro-5-methyl-phenyl)-4-phenyl-2-pyrazolin-3-yl]ethanone
  • 1-[(4R)-4-(3-dimethylaminopropyl)-1-(2-fluoro-5-methylphenyl)-4-phenyl-5H-pyrazol-3-yl]ethanone
  • 1-[(4R)-4-(3-dimethylaminopropyl)-1-(2-fluoro-5-methyl-phenyl)-4-phenyl-5H-pyrazol-3-yl]ethanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Starlite/ChEMBL References
Homo sapiens kinesin family member 11 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Candida albicans kinesin motor domain protein similar to S. cerevisiae KIP1 (YBL063W) microtubule motor complex protein Get druggable targets OG5_128460 All targets in OG5_128460
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K10398 kinesin family member 11, putative Get druggable targets OG5_128460 All targets in OG5_128460
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Entamoeba histolytica kinesin, putative Get druggable targets OG5_128460 All targets in OG5_128460
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Plasmodium falciparum kinesin-5 Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium berghei kinesin-5, putative Get druggable targets OG5_128460 All targets in OG5_128460
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) kinesin-like protein KLP2 Get druggable targets OG5_128460 All targets in OG5_128460
Echinococcus granulosus kinesin family 1 Get druggable targets OG5_128460 All targets in OG5_128460
Candida albicans kinesin motor domain protein similar to S. cerevisiae KIP1 (YBL063W) microtubule motor complex protein Get druggable targets OG5_128460 All targets in OG5_128460
Brugia malayi Kinesin motor domain containing protein Get druggable targets OG5_128460 All targets in OG5_128460
Cryptosporidium parvum kinesin-like boursin, putative Get druggable targets OG5_128460 All targets in OG5_128460
Schistosoma mansoni kinesin eg-5 Get druggable targets OG5_128460 All targets in OG5_128460
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Neospora caninum hypothetical protein Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium knowlesi kinesin-5, putative Get druggable targets OG5_128460 All targets in OG5_128460
Giardia lamblia Kinesin-5 Get druggable targets OG5_128460 All targets in OG5_128460
Echinococcus multilocularis kinesin family 1 Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium yoelii Kinesin motor domain, putative Get druggable targets OG5_128460 All targets in OG5_128460
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Plasmodium vivax kinesin-5 Get druggable targets OG5_128460 All targets in OG5_128460
Cryptosporidium hominis kinesin-like boursin Get druggable targets OG5_128460 All targets in OG5_128460
Toxoplasma gondii kinesin motor domain-containing protein Get druggable targets OG5_128460 All targets in OG5_128460
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0212 0.0212
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0373 0.0942
Brugia malayi RE15519p 0.0039 0.0212 0.0212
Onchocerca volvulus 0.0039 0.0212 0.0922
Entamoeba histolytica cysteine protease, putative 0.0032 0.0108 0.0273
Trypanosoma cruzi kinesin, putative 0.0075 0.0761 0.0761
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.004 0.0226 0.0306
Entamoeba histolytica grainin 2 0.0037 0.0181 0.0457
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0212 0.0212
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.2005 0.2005
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0212 0.0212
Echinococcus multilocularis gamma secretase subunit aph 1 0.0241 0.3257 0.3257
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0373 0.0942
Trypanosoma brucei calpain-like protein, putative 0.0107 0.1247 0.2955
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0267 0.0412
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.004 0.0226 0.0571
Trypanosoma brucei cysteine peptidase C (CPC) 0.023 0.3093 0.7749
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0373 0.0668
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0212 0.0212
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0107 0.1247 0.1247
Schistosoma mansoni hypothetical protein 0.0032 0.0116 0.0116
Leishmania major cathepsin L-like protease 0.0042 0.0267 0.0392
Echinococcus multilocularis calpain A 0.0301 0.4158 0.4158
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0116 0.0021
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0288 0.396 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0039 0.0212 0.0212
Trypanosoma brucei centrin-3 0.0037 0.0181 0.0189
Entamoeba histolytica calpain family cysteine protease, putative 0.0032 0.0116 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0267 0.0674
Brugia malayi Cathepsin L-like precursor 0.0035 0.0159 0.0159
Schistosoma mansoni neuropeptide receptor 0.0039 0.0212 0.0212
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0039 0.0212 0.0212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0267 0.0412
Trypanosoma brucei glucosidase, putative 0.0035 0.0157 0.0127
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0267 0.0674
Entamoeba histolytica cysteine protease, putative 0.0042 0.0267 0.0674
Echinococcus multilocularis cathepsin b 0.0689 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0241 0.3257 0.3257
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0288 0.396 1
Entamoeba histolytica cysteine proteinase, putative 0.0042 0.0267 0.0674
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0032 0.0116 0.0021
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.004 0.0226 0.0306
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0108 0.0108
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0288 0.396 0.396
Echinococcus multilocularis fk506 binding protein 0.0288 0.396 0.396
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0039 0.0212 0.0212
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0169 0.0138
Echinococcus granulosus neuropeptide FF receptor 2 0.0039 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0373 0.0942
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0288 0.396 0.396
Entamoeba histolytica hypothetical protein 0.0035 0.0155 0.039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0267 0.0674
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0267 0.0674
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.004 0.0226 0.5
Leishmania major cathepsin L-like protease 0.0042 0.0267 0.0392
Toxoplasma gondii cathepsin B 0.023 0.3093 1
Brugia malayi G protein-coupled receptor 0.0039 0.0212 0.0212
Schistosoma mansoni hypothetical protein 0.0035 0.0155 0.0155
Echinococcus granulosus GA binding protein alpha chain 0.007 0.0686 0.0686
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0039 0.0212 0.0212
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0212 0.0212
Brugia malayi cathepsin L-like precursor 0.0035 0.0159 0.0159
Onchocerca volvulus 0.0039 0.0212 0.0922
Brugia malayi Cathepsin L-like precursor 0.0042 0.0267 0.0267
Echinococcus granulosus neuropeptide s receptor 0.0039 0.0212 0.0212
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.004 0.0226 0.0226
Entamoeba histolytica cysteine proteinase 2 0.0032 0.0108 0.0273
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0116 0.0116
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.004 0.0226 0.0286
Leishmania major cathepsin L-like protease 0.0042 0.0267 0.0392
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.004 0.0226 0.0571
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Schistosoma mansoni neuropeptide f receptor 76f 0.0039 0.0212 0.0212
Schistosoma mansoni hypothetical protein 0.0215 0.2872 0.2872
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0116 0.0116
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0226 0.0306
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0039 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Entamoeba histolytica cysteine protease, putative 0.0032 0.0108 0.0273
Echinococcus multilocularis 0.004 0.0226 0.0226
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0362 0.0362
Brugia malayi hypothetical protein 0.0039 0.0212 0.0212
Entamoeba histolytica kinesin, putative 0.0032 0.0114 0.0289
Brugia malayi hypothetical protein 0.0039 0.0212 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.023 0.3093 0.7811
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0267 0.0412
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0212 0.0212
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0212 0.0212
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0107 0.1247 0.1247
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0107 0.1247 0.2941
Brugia malayi Cathepsin L-like precursor 0.0042 0.0267 0.0267
Trypanosoma cruzi conserved protein 0.0032 0.0116 0.0116
Schistosoma mansoni hypothetical protein 0.004 0.0226 0.0226
Brugia malayi Ets-domain containing protein 0.007 0.0686 0.0686
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0107 0.1247 0.2955
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0267 0.0412
Brugia malayi calpain family protein 1 0.0285 0.3915 0.3915
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0157 0.0397
Schistosoma mansoni hypothetical protein 0.0039 0.0212 0.0212
Leishmania major peptidylprolyl isomerase-like protein 0.0288 0.396 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0169 0.0169
Onchocerca volvulus 0.0091 0.1004 0.4366
Trichomonas vaginalis fk506-binding protein, putative 0.0288 0.396 1
Onchocerca volvulus 0.0039 0.0212 0.0922
Entamoeba histolytica cysteine protease, putative 0.0032 0.0108 0.0273
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0212 0.0212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0212 0.0212
Echinococcus multilocularis neuropeptide receptor A26 0.0039 0.0212 0.0212
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0032 0.0116 0.0116
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0039 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Brugia malayi MAP kinase sur-1 0.0049 0.0373 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0226 0.0571
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0267 0.0412
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0157 0.0157
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.004 0.0226 0.5
Entamoeba histolytica hypothetical protein 0.0035 0.0155 0.039
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0107 0.1247 0.2941
Leishmania major cathepsin L-like protease 0.0042 0.0267 0.0392
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0301 0.4158 0.4158
Echinococcus multilocularis cysteine protease 0.0042 0.0267 0.0267
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0301 0.0301
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0212 0.0212
Schistosoma mansoni alpha-glucosidase 0.0136 0.1674 0.1674
Onchocerca volvulus 0.0039 0.0212 0.0922
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0267 0.0674
Schistosoma mansoni immunophilin 0.0288 0.396 0.396
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.004 0.0226 0.0731
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0169 0.0169
Trypanosoma brucei Calpain-like protein 1.1 0.0032 0.0116 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0267 0.0674
Plasmodium vivax vivapain-3 0.0032 0.0108 0.0273
Schistosoma mansoni immunophilin 0.0248 0.3364 0.3364
Loa Loa (eye worm) calpain D 0.0032 0.0116 0.0116
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0039 0.0212 0.0212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0267 0.0412
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Echinococcus granulosus dro:myosuppressin receptor 0.0039 0.0212 0.0212
Echinococcus multilocularis g-protein coupled receptor 0.0039 0.0212 0.0212
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0373 0.1206
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0169 0.0169
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0039 0.0212 0.0922
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0169 0.0169
Echinococcus granulosus cathepsin b 0.0689 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0212 0.0212
Echinococcus granulosus peptide allatostatin:somatostatin 0.0039 0.0212 0.0212
Schistosoma mansoni gamma-secretase subunit aph-1 0.0241 0.3257 0.3257
Loa Loa (eye worm) FKBP5 protein 0.0288 0.396 0.396
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0212 0.0212
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.004 0.0226 0.0226
Schistosoma mansoni calpain (C02 family) 0.0107 0.1247 0.1247
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.004 0.0226 0.0226
Onchocerca volvulus 0.0039 0.0212 0.0922
Echinococcus multilocularis programmed cell death protein 0.0037 0.0181 0.0181
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.004 0.0226 0.0571
Echinococcus multilocularis calpain family protein 1, d 0.021 0.2784 0.2784
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Brugia malayi GnHR receptor homolog 0.0039 0.0212 0.0212
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0157 0.0397
Entamoeba histolytica cysteine protease, putative 0.0032 0.0108 0.0273
Onchocerca volvulus Cathepsin F homolog 0.0042 0.0267 0.1161
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0042 0.0267 0.0674
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0032 0.0116 0.0021
Schistosoma mansoni gabp alpha 0.007 0.0686 0.0686
Trichomonas vaginalis calpain, putative 0.0032 0.0116 0.0293
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0288 0.396 0.396
Schistosoma mansoni biogenic amine receptor 0.0039 0.0212 0.0212
Brugia malayi Cathepsin L-like precursor 0.0042 0.0267 0.0267
Onchocerca volvulus 0.0039 0.0212 0.0922
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.004 0.0226 0.0226
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.004 0.0226 0.5
Echinococcus multilocularis G-protein coupled receptor, putative 0.0039 0.0212 0.0212
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0042 0.0267 0.0267
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0039 0.0212 0.0212
Entamoeba histolytica cysteine protease, putative 0.0032 0.0108 0.0273
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0032 0.0116 0.0116
Onchocerca volvulus 0.0039 0.0212 0.0922
Loa Loa (eye worm) TYRA-2 protein 0.0039 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Trypanosoma brucei kinesin, putative 0.0075 0.0761 0.1694
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Trypanosoma cruzi cysteine proteinase, putative 0.0032 0.0108 0.0108
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0212 0.0212
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.004 0.0226 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0039 0.0212 0.0212
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0035 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Trypanosoma brucei protein kinase, putative 0.0049 0.0373 0.0687
Leishmania major cathepsin L-like protease 0.0042 0.0267 0.0392
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0212 0.0212
Giardia lamblia Cathepsin B precursor 0.023 0.3093 0.7811
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0267 0.0674
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0212 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0267 0.0674
Brugia malayi Serotonin receptor 0.0039 0.0212 0.0212
Brugia malayi Papain family cysteine protease containing protein 0.0042 0.0267 0.0267
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0362 0.0362
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0212 0.0212
Brugia malayi Dopamine receptor 0.0039 0.0212 0.0212
Trypanosoma brucei Aph-1 protein, putative 0.0094 0.1043 0.2428
Brugia malayi larval opioid receptor 0.0039 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0212 0.0212
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.004 0.0226 0.0731
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0107 0.1247 0.1247
Brugia malayi neuropeptide F receptor 0.0039 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Echinococcus granulosus 7tm_1 domain containing protein 0.0039 0.0212 0.0212
Echinococcus granulosus calpain A 0.0107 0.1247 0.1247
Loa Loa (eye worm) ctsf protein 0.0042 0.0267 0.0267
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0375 0.0375
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0157 0.0397
Plasmodium vivax unspecified product 0.0032 0.0108 0.0273
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0116 0.0116
Brugia malayi neuropeptide F receptor 0.0039 0.0212 0.0212
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0212 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0226 0.0571
Plasmodium vivax calpain, putative 0.0107 0.1247 0.3148
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0042 0.0267 0.0267
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0169 0.0158
Echinococcus multilocularis somatostatin receptor 0.0039 0.0212 0.0212
Echinococcus granulosus cathepsin b 0.0689 1 1
Loa Loa (eye worm) kinesin-like protein KLP2 0.0032 0.0114 0.0114
Trichomonas vaginalis fk506-binding protein, putative 0.004 0.0226 0.0571
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0116 0.0116
Loa Loa (eye worm) calpain family protein 1 0.021 0.2784 0.2784
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0288 0.396 0.396
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0212 0.0212
Plasmodium falciparum cysteine proteinase falcipain 1 0.0032 0.0108 0.0273
Brugia malayi Cathepsin L-like precursor 0.0042 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0212 0.0212
Giardia lamblia Kinesin-5 0.0032 0.0114 0.0289
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0032 0.0116 0.0293
Toxoplasma gondii cathepsin CPL 0.0042 0.0267 0.0863
Schistosoma mansoni amine GPCR 0.0039 0.0212 0.0212
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0107 0.1247 0.1247
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0039 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0288 0.396 1
Plasmodium falciparum kinesin-5 0.0032 0.0114 0.0289
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0267 0.0412
Leishmania major cathepsin L-like protease 0.0042 0.0267 0.0392
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0157 0.0397
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0157 0.0397
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.004 0.0226 0.0226
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0107 0.1247 0.1247
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0032 0.0116 0.0293
Echinococcus multilocularis calpain 5 0.0107 0.1247 0.1247
Schistosoma mansoni amine GPCR 0.0039 0.0212 0.0212
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0212 0.0212
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0169 0.0169
Onchocerca volvulus 0.0039 0.0212 0.0922
Onchocerca volvulus 0.0039 0.0212 0.0922
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0108 0.0273
Echinococcus granulosus g protein coupled receptor 0.0039 0.0212 0.0212
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0212 0.0212
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0212 0.0212
Echinococcus granulosus cathepsin L 0.0032 0.0108 0.0108
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0373 0.0373
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.023 0.3093 0.7745
Entamoeba histolytica cysteine protease, putative 0.0032 0.0108 0.0273
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0212 0.0212
Echinococcus granulosus calpain A 0.0301 0.4158 0.4158
Onchocerca volvulus 0.0148 0.1857 0.808
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0301 0.0301
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0212 0.0212
Brugia malayi gamma-secretase subunit aph-1 0.0241 0.3257 0.3257
Schistosoma mansoni calpain-7 (C02 family) 0.011 0.129 0.129
Loa Loa (eye worm) calpain 5 0.0075 0.0761 0.0761
Schistosoma mansoni alpha-1 adrenergic receptor 0.0039 0.0212 0.0212
Brugia malayi Ets-domain containing protein 0.007 0.0686 0.0686
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0157 0.0397
Entamoeba histolytica cysteine protease, putative 0.0032 0.0108 0.0273
Leishmania major cathepsin L-like protease 0.0042 0.0267 0.0392
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0159 0.0401
Schistosoma mansoni hypothetical protein 0.0335 0.467 0.467
Trypanosoma brucei Calpain-like protein 2 0.0032 0.0116 0.0021
Schistosoma mansoni growth hormone secretagogue receptor 0.0039 0.0212 0.0212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0212 0.0212
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0157 0.0157
Onchocerca volvulus 0.0042 0.0267 0.1161
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0157 0.0508
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0039 0.0212 0.0212
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.004 0.0226 0.0226
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0108 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0267 0.0674
Brugia malayi follicle stimulating hormone receptor 0.0039 0.0212 0.0212
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0157 0.0397
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.004 0.0226 0.0571
Loa Loa (eye worm) calpain family protein 1 0.0285 0.3915 0.3915
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.004 0.0226 0.0571
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.004 0.0226 0.0571
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0155 0.0155
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0042 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0252 0.3429 0.3429
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0157 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0267 0.0674
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0689 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0039 0.0212 0.0212
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0032 0.0116 0.0293
Trypanosoma brucei antigen, putative 0.0107 0.1247 0.2955
Onchocerca volvulus 0.004 0.0226 0.0984
Echinococcus multilocularis sex peptide receptor 0.0039 0.0212 0.0212
Brugia malayi G-protein coupled receptor 0.0039 0.0212 0.0212
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0212 0.0212
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0288 0.396 1
Echinococcus granulosus FK506 binding protein 2 0.004 0.0226 0.0226
Trypanosoma brucei caltractin, putative 0.0037 0.0181 0.0189
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Trichomonas vaginalis fk506 binding protein, putative 0.004 0.0226 0.0571
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0212 0.0212
Schistosoma mansoni immunophilin 0.0288 0.396 0.396
Echinococcus multilocularis cathepsin L cysteine protease 0.0042 0.0267 0.0267
Onchocerca volvulus 0.0039 0.0212 0.0922
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.2005 0.2005
Echinococcus granulosus serotonin receptor 0.0039 0.0212 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0267 0.0674
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0212 0.0212
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0039 0.0212 0.0212
Trypanosoma cruzi centrin-3 0.0037 0.0181 0.0181
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.004 0.0226 0.0306
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0288 0.396 1
Entamoeba histolytica calpain large subunit domain III containing protein 0.0075 0.0761 0.1921
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.004 0.0226 0.0226
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0116 0.0021
Echinococcus multilocularis kinesin family 1 0.0247 0.3356 0.3356
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0288 0.396 0.396
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0212 0.0212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0267 0.0412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0212 0.0212
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0032 0.0116 0.0021
Brugia malayi G protein-coupled receptor F59B2.13 0.0039 0.0212 0.0212
Echinococcus multilocularis cathepsin L 0.0032 0.0108 0.0108
Echinococcus granulosus cathepsin L cysteine protease 0.0032 0.0108 0.0108
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0212 0.0212
Onchocerca volvulus 0.0042 0.0267 0.1161
Loa Loa (eye worm) cysteine protease 0.0042 0.0267 0.0267
Schistosoma mansoni amine GPCR 0.0039 0.0212 0.0212
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0157 0.0397
Leishmania major fk506-binding protein 1-like protein 0.0288 0.396 1
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.004 0.0226 0.5
Trichomonas vaginalis calcium binding protein, putative 0.0037 0.0181 0.0457
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0301 0.4158 0.4158
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Schistosoma mansoni Mername-AA248 (C02 family) 0.0107 0.1247 0.1247
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0212 0.0212
Schistosoma mansoni neuropeptide receptor 0.0039 0.0212 0.0212
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0039 0.0212 0.0212
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.004 0.0226 0.0226
Leishmania major kinesin, putative 0.0075 0.0761 0.1677
Toxoplasma gondii kinesin motor domain-containing protein 0.0032 0.0114 0.0369
Giardia lamblia Cathepsin B precursor 0.023 0.3093 0.7811
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0116 0.0116
Schistosoma mansoni alpha glucosidase 0.0035 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.004 0.0226 0.0226
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0039 0.0212 0.0212
Echinococcus granulosus g protein coupled receptor 0.0039 0.0212 0.0212
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0108 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0108 0.0273
Schistosoma mansoni adenoreceptor 0.0039 0.0212 0.0212
Brugia malayi Cathepsin L-like precursor 0.0042 0.0267 0.0267
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0039 0.0212 0.0212
Trypanosoma brucei calpain-like protein, putative 0.0107 0.1247 0.2955
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0373 0.0687
Plasmodium falciparum cysteine proteinase falcipain 3 0.0042 0.0267 0.0674
Schistosoma mansoni ets-related 0.0213 0.2834 0.2834
Plasmodium vivax vivapain-1 0.0032 0.0108 0.0273
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0267 0.0674
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0212 0.0212
Trypanosoma cruzi centrin, putative 0.0037 0.0181 0.0181
Entamoeba histolytica hypothetical protein 0.0035 0.0155 0.039
Echinococcus granulosus cysteine protease 0.0032 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0373 0.0942
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0155 0.0155
Brugia malayi AKH receptor 0.0039 0.0212 0.0212
Onchocerca volvulus 0.0039 0.0212 0.0922
Entamoeba histolytica hypothetical protein 0.0035 0.0155 0.039
Entamoeba histolytica cysteine proteinase, putative 0.0042 0.0267 0.0674
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0159 0.0159
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0116 0.0116
Plasmodium vivax kinesin-5 0.0032 0.0114 0.0289
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0032 0.0116 0.0116
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0169 0.0169
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0042 0.0267 0.0674
Echinococcus granulosus calpain 0.0107 0.1247 0.1247
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0108 0.0273
Echinococcus granulosus kinesin family 1 0.0247 0.3356 0.3356
Loa Loa (eye worm) melatonin receptor type 1A 0.0039 0.0212 0.0212
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.0686 0.0686
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.2005 0.2005
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0288 0.396 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0042 0.0267 0.0267
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0212 0.0212
Echinococcus granulosus hypothetical protein 0.0039 0.0212 0.0212
Echinococcus granulosus calpain 5 0.0107 0.1247 0.1247
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0288 0.396 0.396
Schistosoma mansoni calpain-7 (C02 family) 0.011 0.129 0.129
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.004 0.0226 0.0731
Giardia lamblia Cathepsin B precursor 0.023 0.3093 0.7811
Trichomonas vaginalis calpain, putative 0.0032 0.0116 0.0293
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0159 0.0401
Trypanosoma brucei Calpain-like protein CALP1.3 0.0032 0.0116 0.0021
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0212 0.0212
Echinococcus multilocularis programmed cell death protein 0.0037 0.0181 0.0181
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0157 0.0157
Schistosoma mansoni hypothetical protein 0.0039 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Entamoeba histolytica cysteine protease, putative 0.0032 0.0108 0.0273
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.3115 0.3115
Schistosoma mansoni hypothetical protein 0.0039 0.0212 0.0212
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0039 0.0212 0.0212
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.004 0.0226 0.0226
Brugia malayi hypothetical protein 0.0039 0.0212 0.0212
Echinococcus granulosus calpain 7 C02 family 0.0107 0.1247 0.1247
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0373 0.0373
Trichomonas vaginalis calmodulin, putative 0.0037 0.0181 0.0457
Loa Loa (eye worm) hypothetical protein 0.0232 0.3115 0.3115
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Brugia malayi calpain 7 0.0107 0.1247 0.1247
Trypanosoma cruzi cysteine peptidase, putative 0.0042 0.0267 0.0267
Echinococcus multilocularis neuropeptide FF receptor 2 0.0039 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0177 0.2299 0.2299
Onchocerca volvulus 0.0047 0.0341 0.1484
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0169 0.0427
Loa Loa (eye worm) calpain 0.0107 0.1247 0.1247
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0212 0.0212
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.004 0.0226 0.0226
Onchocerca volvulus 0.0042 0.0267 0.1161
Loa Loa (eye worm) hypothetical protein 0.0248 0.3364 0.3364
Brugia malayi Serotonin receptor 0.0039 0.0212 0.0212
Brugia malayi calpain 5 0.0032 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Trypanosoma cruzi cysteine peptidase, putative 0.0042 0.0267 0.0267
Schistosoma mansoni calpain C (C02 family) 0.0107 0.1247 0.1247
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0373 0.0373
Loa Loa (eye worm) fibroinase 0.0042 0.0267 0.0267
Brugia malayi hypothetical protein 0.0035 0.0155 0.0155
Echinococcus granulosus programmed cell death protein 0.0037 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0036 0.0169 0.0169
Plasmodium falciparum calpain 0.0032 0.0116 0.0293
Echinococcus granulosus allatostatin A receptor 0.0039 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0157 0.0397
Loa Loa (eye worm) hypothetical protein 0.0049 0.0375 0.0375
Trichomonas vaginalis fk506-binding protein, putative 0.004 0.0226 0.0571
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0301 0.0301
Echinococcus multilocularis calpain 0.0107 0.1247 0.1247
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0212 0.0212
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0039 0.0212 0.0212
Echinococcus granulosus alpha 1A adrenergic receptor 0.0039 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0039 0.0212 0.0212
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.3115 0.3115
Schistosoma mansoni neuropeptide receptor 0.0039 0.0212 0.0212
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.004 0.0226 0.0286
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.2005 0.2005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0267 0.0674
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0035 0.0159 0.0159
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0212 0.0212
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0373 0.0373
Echinococcus multilocularis allatostatin A receptor 0.0039 0.0212 0.0212
Onchocerca volvulus 0.0039 0.0212 0.0922
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0689 1 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0032 0.0108 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0042 0.0267 0.0674
Loa Loa (eye worm) hypothetical protein 0.0035 0.0159 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0267 0.0674
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0212 0.0212
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0107 0.1247 0.1247
Echinococcus multilocularis serotonin receptor 0.0039 0.0212 0.0212
Brugia malayi G-protein coupled receptor 0.0039 0.0212 0.0212
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0212 0.0212
Entamoeba histolytica cysteine protease, putative 0.0032 0.0108 0.0273
Trypanosoma brucei calpain-like protein, putative 0.0107 0.1247 0.2955
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0267 0.0412
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0212 0.0212
Echinococcus granulosus fmrfamide receptor 0.0039 0.0212 0.0212
Echinococcus granulosus somatostatin receptor 0.0039 0.0212 0.0212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0267 0.0674
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0288 0.396 0.396
Loa Loa (eye worm) hypothetical protein 0.0148 0.1857 0.1857
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.004 0.0226 0.0226
Schistosoma mansoni fk506 binding protein 0.004 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0212 0.0212
Onchocerca volvulus 0.004 0.0226 0.0984
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0267 0.0674
Schistosoma mansoni survival motor neuron protein 0.0047 0.0341 0.0341
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0248 0.3364 0.3364
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0212 0.0212
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0039 0.0212 0.0212
Schistosoma mansoni myosin xvIII 0.0039 0.0212 0.0212
Brugia malayi Fli-1 protein 0.0213 0.2834 0.2834
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0032 0.0116 0.0116
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0212 0.0212
Brugia malayi calpain 5 0.0075 0.0761 0.0761
Echinococcus granulosus g protein coupled receptor 0.0039 0.0212 0.0212
Onchocerca volvulus Cathepsin L homolog 0.0042 0.0267 0.1161
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0341 0.0341
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0248 0.3364 0.3364
Plasmodium vivax vivapain-2 0.0042 0.0267 0.0674
Loa Loa (eye worm) hypothetical protein 0.0035 0.0159 0.0159
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0375 0.0375
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0212 0.0212
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0039 0.0212 0.0212
Onchocerca volvulus 0.0039 0.0212 0.0922
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0039 0.0212 0.0212
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0032 0.0116 0.0116
Trypanosoma cruzi centrin, putative 0.0037 0.0181 0.0181
Trichomonas vaginalis calpain, putative 0.0032 0.0116 0.0293
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0042 0.0267 0.0267
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.2005 0.2005
Entamoeba histolytica cysteine protease, putative 0.0032 0.0108 0.0273
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0107 0.1247 0.2941
Brugia malayi hypothetical protein 0.0039 0.0212 0.0212
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0301 0.4158 0.4158
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0301 0.4158 0.4158
Schistosoma mansoni calpain-2 (C02 family) 0.0032 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Schistosoma mansoni opsin-like receptor 0.0039 0.0212 0.0212
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0373 0.0373
Leishmania major cathepsin L-like protease 0.0042 0.0267 0.0392
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0116 0.0116
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0212 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0267 0.0674
Echinococcus multilocularis serotonin receptor 0.0039 0.0212 0.0212
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.023 0.3093 0.3093
Echinococcus granulosus sex peptide receptor 0.0039 0.0212 0.0212
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0107 0.1247 0.1247
Echinococcus granulosus geminin 0.0335 0.467 0.467
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0288 0.396 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0039 0.0212 0.0212
Brugia malayi hypothetical protein 0.0039 0.0212 0.0212
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0108 0.0273
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0373 0.0373
Schistosoma mansoni biogenic amine receptor 0.0039 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.021 0.2784 0.2784
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0159 0.0401
Brugia malayi hypothetical protein 0.0039 0.0212 0.0212
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0212 0.0212
Trichomonas vaginalis hypothetical protein 0.0032 0.0116 0.0293
Schistosoma mansoni opsin-like receptor 0.0039 0.0212 0.0212
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0108 0.0273
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0212 0.0212
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0032 0.0116 0.0376
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0032 0.0116 0.0116
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0267 0.0674
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0032 0.0116 0.0293
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0032 0.0116 0.0293
Trypanosoma cruzi cysteine proteinase, putative 0.0032 0.0108 0.0108
Brugia malayi hypothetical protein 0.0039 0.0212 0.0212
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0288 0.396 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.0686 0.0686
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.004 0.0226 0.0226
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.004 0.0226 0.0571
Echinococcus granulosus g-protein coupled receptor 0.0039 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0116 0.0116
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0288 0.396 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0107 0.1247 0.1247
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0288 0.396 0.396
Echinococcus granulosus cathepsin l1 0.0042 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Schistosoma mansoni hypothetical protein 0.0039 0.0212 0.0212
Brugia malayi Dopamine receptor protein 1 0.0039 0.0212 0.0212
Brugia malayi calpain family protein 1 0.0285 0.3915 0.3915
Trichomonas vaginalis immunophilin, putative 0.0288 0.396 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.006 0.0533 0.0533
Onchocerca volvulus 0.0042 0.0267 0.1161
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0212 0.0212
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0108 0.0108
Schistosoma mansoni opsin-like receptor 0.0039 0.0212 0.0212
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0107 0.1247 0.2955
Loa Loa (eye worm) hypothetical protein 0.0689 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0039 0.0212 0.0212
Onchocerca volvulus 0.0039 0.0212 0.0922
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0212 0.0212
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0288 0.396 0.396
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0039 0.0212 0.0212
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0032 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Loa Loa (eye worm) fli-1 protein 0.0213 0.2834 0.2834
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0212 0.0212
Echinococcus multilocularis neuropeptide s receptor 0.0039 0.0212 0.0212
Trypanosoma cruzi cysteine protease, putative 0.0032 0.0108 0.0108
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.004 0.0226 0.0286
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0169 0.0169
Trypanosoma brucei cysteine peptidase, putative 0.0032 0.0116 0.0021
Brugia malayi putative neuropeptide receptor 0.0039 0.0212 0.0212
Entamoeba histolytica cysteine protease, putative 0.0032 0.0108 0.0273
Echinococcus multilocularis calpain 7 (C02 family) 0.0107 0.1247 0.1247
Trypanosoma cruzi cruzipain precursor, putative 0.0042 0.0267 0.0267
Echinococcus granulosus 7TM GPCR rhodopsin 0.0039 0.0212 0.0212
Onchocerca volvulus 0.0177 0.2299 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0032 0.0116 0.0021
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0039 0.0212 0.0212
Trypanosoma brucei calpain-like protein, putative 0.0107 0.1247 0.2955
Giardia lamblia Hypothetical protein 0.004 0.0226 0.0571
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0032 0.0116 0.0116
Plasmodium vivax vivapain-2 0.0042 0.0267 0.0674
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0373 0.0373
Entamoeba histolytica protein kinase, putative 0.0076 0.0767 0.1938
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0212 0.0212
Trypanosoma brucei hypothetical protein 0.0032 0.0116 0.0021
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0212 0.0212
Brugia malayi hypothetical protein 0.0148 0.1857 0.1857
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Echinococcus granulosus neuropeptide receptor 0.0039 0.0212 0.0212
Schistosoma mansoni histamine h1 receptor 0.0039 0.0212 0.0212
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0157 0.0397
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0157 0.0157
Entamoeba histolytica cysteine proteinase 1, putative 0.0032 0.0108 0.0273
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0212 0.0212
Echinococcus multilocularis hypothetical protein 0.0107 0.1247 0.1247
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0212 0.0212
Schistosoma mansoni hypothetical protein 0.0335 0.467 0.467
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0267 0.0412
Brugia malayi Cathepsin L-like precursor 0.0035 0.0159 0.0159
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0157 0.0397
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0157 0.0107
Trypanosoma brucei calpain, putative 0.0032 0.0116 0.0021
Onchocerca volvulus 0.0039 0.0212 0.0922
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0288 0.396 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0373 0.0373
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0285 0.3915 0.3915
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0212 0.0212
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0107 0.1247 0.1247
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0169 0.0169
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Echinococcus granulosus gamma secretase subunit aph 1 0.0241 0.3257 0.3257
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0373 0.0373
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0039 0.0212 0.0212
Schistosoma mansoni cathepsin F (C01 family) 0.0042 0.0267 0.0267
Entamoeba histolytica cysteine protease, putative 0.0032 0.0108 0.0273
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0288 0.396 1
Trypanosoma cruzi kinesin, putative 0.0075 0.0761 0.0761
Echinococcus granulosus cathepsin l1 0.0035 0.0159 0.0159
Trypanosoma brucei calpain, putative 0.0032 0.0116 0.0021
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Brugia malayi Cathepsin L-like precursor 0.0042 0.0267 0.0267
Leishmania major cysteine peptidase A (CPA) 0.0042 0.0267 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0169 0.0427
Schistosoma mansoni amine GPCR 0.0039 0.0212 0.0212
Schistosoma mansoni hypothetical protein 0.0034 0.014 0.014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0267 0.0412
Schistosoma mansoni cathepsin F (C01 family) 0.0042 0.0267 0.0267
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0267 0.0674
Brugia malayi hypothetical protein 0.0232 0.3115 0.3115
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0169 0.0427
Brugia malayi calpain D 0.0032 0.0116 0.0116
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0689 1 1
Trypanosoma cruzi Aph-1 protein, putative 0.0094 0.1043 0.1043
Echinococcus granulosus orexin receptor type 2 0.0039 0.0212 0.0212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0267 0.0674
Schistosoma mansoni neuropeptide receptor 0.0039 0.0212 0.0212
Schistosoma mansoni amine GPCR 0.0039 0.0212 0.0212
Echinococcus multilocularis cathepsin b 0.0689 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0042 0.0267 0.0267
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0039 0.0212 0.0212
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0212 0.0212
Onchocerca volvulus Cathepsin L homolog 0.0042 0.0267 0.1161
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0689 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0212 0.0212
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0039 0.0212 0.0212
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0257 0.0648
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0212 0.0212
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0288 0.396 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Entamoeba histolytica cysteine protease, putative 0.0032 0.0108 0.0273
Brugia malayi hypothetical protein 0.0039 0.0212 0.0212
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0257 0.0648
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0373 0.0668
Brugia malayi Melatonin receptor type 1A 0.0039 0.0212 0.0212
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0212 0.0212
Echinococcus multilocularis geminin 0.0335 0.467 0.467
Loa Loa (eye worm) hypothetical protein 0.0285 0.3915 0.3915
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0288 0.396 0.396
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0212 0.0212
Echinococcus granulosus G protein coupled receptor 139 0.0039 0.0212 0.0212
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0039 0.0212 0.0212
Schistosoma mansoni alpha-glucosidase 0.0136 0.1674 0.1674
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0039 0.0212 0.0212
Toxoplasma gondii hypothetical protein 0.0032 0.0116 0.0376
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0212 0.0212
Brugia malayi sulfakinin receptor protein 0.0039 0.0212 0.0212
Onchocerca volvulus Neuropeptide F receptor homolog 0.0039 0.0212 0.0922
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0288 0.396 0.396
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0169 0.0169
Onchocerca volvulus 0.0042 0.0267 0.1161
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0032 0.0116 0.0293
Trypanosoma brucei Calpain-like protein 1.2 0.0032 0.0116 0.0021
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0169 0.0169
Onchocerca volvulus 0.0039 0.0212 0.0922
Onchocerca volvulus 0.0039 0.0212 0.0922
Echinococcus granulosus neuropeptide receptor 0.0039 0.0212 0.0212
Echinococcus multilocularis G protein coupled receptor 139 0.0039 0.0212 0.0212
Echinococcus granulosus cathepsin L cysteine proteinase 0.0042 0.0267 0.0267
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0039 0.0212 0.0212
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0108 0.0273
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0267 0.0674
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0116 0.0293
Schistosoma mansoni kinesin eg-5 0.0032 0.0114 0.0114
Echinococcus granulosus neuropeptide receptor A26 0.0039 0.0212 0.0212
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0032 0.0116 0.0116
Echinococcus multilocularis cysteine protease 0.0042 0.0267 0.0267
Trypanosoma cruzi Aph-1 protein, putative 0.0094 0.1043 0.1043
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0373 0.0942
Brugia malayi hypothetical protein 0.0039 0.0212 0.0212
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.023 0.3093 0.3093
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0042 0.0267 0.0267
Brugia malayi ORL1-like opioid receptor 0.0039 0.0212 0.0212
Schistosoma mansoni hypothetical protein 0.0047 0.0341 0.0341
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0042 0.0267 0.0674
Brugia malayi Kinesin motor domain containing protein 0.0032 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0157 0.0157
Onchocerca volvulus 0.0035 0.0159 0.0691
Brugia malayi hypothetical protein 0.0039 0.0212 0.0212
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0032 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0212
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.004 0.0226 0.0731
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.004 0.0226 0.0226
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0169 0.0427
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0108 0.0108
Brugia malayi Dopamine receptor protein 2 0.0039 0.0212 0.0212
Loa Loa (eye worm) cathepsin B 0.023 0.3093 0.3093
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0689 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0035 0.0159 0.0159
Onchocerca volvulus 0.0042 0.0267 0.1161
Echinococcus multilocularis dro:myosuppressin receptor 0.0039 0.0212 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0267 0.0674
Trypanosoma cruzi cysteine peptidase, putative 0.0042 0.0267 0.0267
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0032 0.0116 0.0116
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0169 0.0427
Onchocerca volvulus 0.0042 0.0267 0.1161
Schistosoma mansoni biogenic amine receptor 0.0039 0.0212 0.0212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0267 0.0674
Echinococcus multilocularis orexin receptor type 2 0.0039 0.0212 0.0212
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0107 0.1247 0.1247
Trypanosoma cruzi cysteine peptidase, putative 0.0042 0.0267 0.0267
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0034 0.014 0.014

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 3.2 nM Inhibition of KSP-induced nucleolin phosphorylation in cell-based mitotic arrest assay ChEMBL. 17766111
EC50 (functional) = 3.2 nM Inhibition of KSP-induced nucleolin phosphorylation in cell-based mitotic arrest assay ChEMBL. 17766111
EC99 (functional) = 67 nM Mitotic arrest in human A2780 cells xenografted nude mouse assessed as induction of phospho-histone H3 at 3.5 mg/kg ChEMBL. 17766111
EC99 (functional) = 67 nM Mitotic arrest in human A2780 cells xenografted nude mouse assessed as induction of phospho-histone H3 at 3.5 mg/kg ChEMBL. 17766111
IC50 (binding) = 0.2 nM Inhibition of kinesin spindle protein by ATPase assay ChEMBL. 17766111
IC50 (binding) = 0.2 nM Inhibition of kinesin spindle protein by ATPase assay ChEMBL. 17766111
IC50 = 3036 nM Inhibition of hERG expressed in HEK cells ChEMBL. 17766111
IC50 = 3036 nM Inhibition of hERG expressed in HEK cells ChEMBL. 17766111
PB (ADMET) = 93 % Protein binding in mouse plasma ChEMBL. 17766111
PB (ADMET) = 93 % Protein binding in mouse plasma ChEMBL. 17766111
PB (ADMET) = 96 % Protein binding in human plasma ChEMBL. 17766111
Ratio IC50 (functional) = 1.6 Ratio of IC50 for KB-V-1 cells to IC50 for KB-3-1 cells ChEMBL. 17766111
Solubility > 4 mg/ml Solubility of the compound at pH 4 ChEMBL. 17766111

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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