Detailed information for compound 460313

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 345.434 | Formula: C23H23NO2
  • H donors: 0 H acceptors: 2 LogP: 3.39 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCC2(C(=C1)CCN(C2)C(=O)c1ccccc1)Cc1ccccc1
  • InChi: 1S/C23H23NO2/c25-21-11-13-23(16-18-7-3-1-4-8-18)17-24(14-12-20(23)15-21)22(26)19-9-5-2-6-10-19/h1-10,15H,11-14,16-17H2
  • InChiKey: GTNLBGMCZKIRIZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine protease, putative 0.0036 0.0092 0.0545
Loa Loa (eye worm) hypothetical protein 0.0029 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0034 0.0062 0.006
Trypanosoma brucei caltractin, putative 0.0042 0.017 0.0262
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0223 0.0438
Echinococcus multilocularis serotonin receptor 0.0052 0.0288 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0223 0.0716
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0164 0.0524
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0052 0.0288 0.0288
Giardia lamblia Cathepsin B precursor 0.0278 0.3094 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0109 0.0345
Onchocerca volvulus Cathepsin L homolog 0.0047 0.0223 0.1006
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0275 0.0273
Onchocerca volvulus 0.0052 0.0288 0.1302
Echinococcus multilocularis neuropeptide receptor 0.0052 0.0288 0.0287
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0288 0.0287
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.057 0.0568
Onchocerca volvulus 0.0047 0.0223 0.1006
Plasmodium falciparum cysteine proteinase falcipain 3 0.0047 0.0223 0.1345
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0052 0.0288 0.0287
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0125 0.1193 0.1191
Brugia malayi GnHR receptor homolog 0.0052 0.0288 0.0287
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0458 0.5338 1
Echinococcus multilocularis neuropeptide receptor 0.0052 0.0288 0.0287
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0127 0.0569
Trichomonas vaginalis calpain, putative 0.0037 0.0109 0.0345
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.138 0.1379
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0092 0.0545
Leishmania major cathepsin L-like protease 0.0047 0.0223 0.0384
Echinococcus granulosus intermediate filament protein 0.0029 0.0007 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0029 0.0002 0.0002
Brugia malayi Dopamine receptor 0.0052 0.0288 0.0287
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.021 0.0208
Trichomonas vaginalis calcium binding protein, putative 0.0042 0.017 0.0545
Trypanosoma cruzi centrin, putative 0.0042 0.017 0.0168
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0109 0.0107
Echinococcus granulosus alpha 1A adrenergic receptor 0.0052 0.0288 0.0287
Echinococcus granulosus G protein coupled receptor 139 0.0052 0.0288 0.0287
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0534 0.0532
Trypanosoma brucei calpain-like protein, putative 0.0125 0.1193 0.3668
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0125 0.1193 0.3632
Echinococcus granulosus cathepsin l cysteine peptidase 0.0047 0.0223 0.0221
Onchocerca volvulus 0.0052 0.0288 0.1302
Entamoeba histolytica cysteine protease, putative 0.0047 0.0223 0.1345
Brugia malayi Cathepsin L-like cysteine proteinase 0.0039 0.0134 0.0132
Brugia malayi sulfakinin receptor protein 0.0052 0.0288 0.0287
Echinococcus granulosus neuropeptide receptor 0.0052 0.0288 0.0287
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0534 0.0532
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0109 0.0057
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0052 0.0288 0.0287
Loa Loa (eye worm) hypothetical protein 0.0029 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0023
Trypanosoma cruzi conserved protein 0.0037 0.0109 0.0107
Brugia malayi hypothetical protein 0.0052 0.0288 0.0287
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0052 0.0288 0.1302
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0134 0.08
Brugia malayi Cathepsin L-like precursor 0.0039 0.0134 0.0132
Onchocerca volvulus 0.0052 0.0288 0.1302
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0109 0.0107
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0223 0.0221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0223 0.0716
Trypanosoma cruzi cysteine proteinase, putative 0.0036 0.0092 0.009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.021 0.0208
Onchocerca volvulus 0.0052 0.0288 0.1302
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0092 0.0545
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0223 0.0438
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0161 0.1648 0.1646
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0037 0.0109 0.0345
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0037 0.0109 0.0107
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0161 0.1648 0.5323
Echinococcus multilocularis allatostatin A receptor 0.0052 0.0288 0.0287
Trypanosoma brucei Calpain-like protein CALP1.3 0.0037 0.0109 0.0057
Trypanosoma cruzi centrin-3 0.0042 0.017 0.0168
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0223 0.0716
Echinococcus multilocularis geminin 0.0181 0.1899 0.1898
Brugia malayi Cathepsin L-like precursor 0.0047 0.0223 0.0221
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Schistosoma mansoni calpain C (C02 family) 0.0125 0.1193 0.1191
Entamoeba histolytica cysteine protease, putative 0.0036 0.0092 0.0545
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0275 0.0883
Loa Loa (eye worm) hypothetical protein 0.0833 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0288 0.0287
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0275 0.0273
Onchocerca volvulus 0.0052 0.0288 0.1302
Trypanosoma brucei calpain-like protein, putative 0.0125 0.1193 0.3668
Loa Loa (eye worm) calpain family protein 1 0.0243 0.2668 0.2668
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0047 0.0223 0.0716
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Schistosoma mansoni neuropeptide receptor 0.0052 0.0288 0.0287
Brugia malayi calpain family protein 1 0.0331 0.3753 0.3752
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Echinococcus granulosus programmed cell death protein 0.0042 0.017 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0223 0.0716
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0223 0.1345
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0288 0.0287
Brugia malayi calpain family protein 1 0.0331 0.3753 0.3752
Trichomonas vaginalis fk506-binding protein, putative 0.0161 0.1648 0.5323
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Brugia malayi hypothetical protein 0.0075 0.057 0.0568
Schistosoma mansoni calpain-7 (C02 family) 0.0125 0.1193 0.1191
Loa Loa (eye worm) calpain D 0.0037 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Schistosoma mansoni intermediate filament proteins 0.0029 0.0007 0.0005
Echinococcus granulosus cathepsin b 0.0833 1 1
Echinococcus granulosus g protein coupled receptor 0.0052 0.0288 0.0287
Trichomonas vaginalis calmodulin, putative 0.0042 0.017 0.0545
Onchocerca volvulus 0.0052 0.0288 0.1302
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0223 0.1345
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0877 0.0876
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0223 0.0716
Echinococcus multilocularis G-protein coupled receptor, putative 0.0052 0.0288 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0092 0.029
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0047 0.0223 0.0221
Entamoeba histolytica cysteine protease, putative 0.0036 0.0092 0.0545
Echinococcus granulosus hypothetical protein 0.0052 0.0288 0.0287
Schistosoma mansoni adenoreceptor 0.0052 0.0288 0.0287
Entamoeba histolytica cysteine proteinase 1, putative 0.0036 0.0092 0.0545
Schistosoma mansoni hypothetical protein 0.0181 0.1899 0.1898
Onchocerca volvulus 0.0047 0.0223 0.1006
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0037 0.0109 0.0107
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0288 0.0288
Schistosoma mansoni hypothetical protein 0.0181 0.1899 0.1898
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0288 0.0287
Entamoeba histolytica cysteine protease, putative 0.0036 0.0092 0.0545
Brugia malayi hypothetical protein 0.0052 0.0288 0.0287
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0288 0.0287
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0109 0.0107
Schistosoma mansoni growth hormone secretagogue receptor 0.0052 0.0288 0.0287
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0288 0.0287
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0164 0.0163
Leishmania major cathepsin L-like protease 0.0047 0.0223 0.0384
Loa Loa (eye worm) cysteine protease 0.0047 0.0223 0.0223
Brugia malayi calpain 7 0.0125 0.1193 0.1191
Loa Loa (eye worm) hypothetical protein 0.0107 0.0968 0.0968
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0288 0.0287
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0062 0.006
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0047 0.0223 0.1345
Echinococcus multilocularis lamin 0.0029 0.0007 0.0005
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0349 0.398 0.3979
Schistosoma mansoni calpain-7 (C02 family) 0.0125 0.1193 0.1191
Loa Loa (eye worm) hypothetical protein 0.0139 0.1372 0.1372
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0534 0.1721
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.0002 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0275 0.0883
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0223 0.0716
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.0092 0.009
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0275 0.0273
Loa Loa (eye worm) hypothetical protein 0.0073 0.0549 0.0549
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0223 0.0716
Schistosoma mansoni hypothetical protein 0.0075 0.057 0.0568
Trypanosoma brucei calpain-like protein, putative 0.0125 0.1193 0.3668
Loa Loa (eye worm) ctsf protein 0.0047 0.0223 0.0223
Leishmania major fk506-binding protein 1-like protein 0.0161 0.1648 0.5155
Trichomonas vaginalis chromobox protein, putative 0.007 0.0507 0.1634
Echinococcus granulosus neuropeptide s receptor 0.0511 0.5997 0.5996
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0037 0.0109 0.0107
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0288 0.0287
Plasmodium falciparum cysteine proteinase falcipain 1 0.0036 0.0092 0.0545
Trypanosoma brucei cysteine peptidase, putative 0.0037 0.0109 0.0057
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0052 0.0288 0.0287
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0288 0.0287
Schistosoma mansoni amine GPCR 0.0052 0.0288 0.0287
Brugia malayi RNA binding protein 0.0063 0.0425 0.0423
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.021 0.0208
Entamoeba histolytica cysteine protease, putative 0.0036 0.0092 0.0545
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0161 0.1648 0.5323
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0073 0.0549 0.0547
Onchocerca volvulus 0.0052 0.0288 0.1302
Brugia malayi putative neuropeptide receptor 0.0052 0.0288 0.0287
Schistosoma mansoni hypothetical protein 0.0037 0.0109 0.0107
Echinococcus granulosus GPCR family 2 0.0034 0.0062 0.006
Trypanosoma cruzi cruzipain precursor, putative 0.0047 0.0223 0.0221
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0288 0.0287
Echinococcus granulosus cathepsin L cysteine proteinase 0.0047 0.0223 0.0221
Loa Loa (eye worm) hypothetical protein 0.0051 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Trypanosoma brucei Calpain-like protein 1.2 0.0037 0.0109 0.0057
Onchocerca volvulus 0.0029 0.0007 0.0022
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0549 0.0547
Schistosoma mansoni biogenic amine receptor 0.0052 0.0288 0.0287
Echinococcus granulosus g-protein coupled receptor 0.0052 0.0288 0.0287
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0052 0.0288 0.0287
Echinococcus multilocularis fk506 binding protein 0.0161 0.1648 0.1646
Onchocerca volvulus 0.0052 0.0288 0.1302
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0288 0.0287
Onchocerca volvulus 0.0052 0.0288 0.1302
Schistosoma mansoni hypothetical protein 0.0052 0.0288 0.0287
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0534 0.0534
Trypanosoma brucei kinesin, putative 0.0087 0.0727 0.2116
Leishmania major cathepsin L-like protease 0.0047 0.0223 0.0384
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0164 0.0163
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0534 0.0532
Schistosoma mansoni opsin-like receptor 0.0052 0.0288 0.0287
Echinococcus granulosus neuropeptide FF receptor 2 0.0052 0.0288 0.0287
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0288 0.0287
Brugia malayi Cathepsin L-like precursor 0.0047 0.0223 0.0221
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0288 0.0287
Echinococcus multilocularis cysteine protease 0.0047 0.0223 0.0221
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0125 0.1193 0.1191
Echinococcus multilocularis dro:myosuppressin receptor 0.0052 0.0288 0.0287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0223 0.0438
Schistosoma mansoni amine GPCR 0.0052 0.0288 0.0287
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0288 0.0287
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0275 0.0275
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0223 0.0438
Loa Loa (eye worm) hypothetical protein 0.0029 0.0002 0.0002
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0125 0.1193 0.1191
Onchocerca volvulus 0.0029 0.0007 0.0022
Onchocerca volvulus 0.0072 0.0534 0.2418
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0288 0.0287
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0109 0.0057
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0275 0.0557
Echinococcus multilocularis calpain 7 (C02 family) 0.0125 0.1193 0.1191
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0288 0.0287
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0109 0.0107
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0037 0.0109 0.0345
Brugia malayi Cathepsin L-like precursor 0.0047 0.0223 0.0221
Schistosoma mansoni chromobox protein 0.007 0.0507 0.0505
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0425 0.0423
Echinococcus multilocularis orexin receptor type 2 0.0052 0.0288 0.0287
Loa Loa (eye worm) calpain 5 0.0087 0.0727 0.0727
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0349 0.398 0.3979
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0331 0.3753 0.3752
Brugia malayi TAR-binding protein 0.0063 0.0425 0.0423
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0288 0.0287
Trypanosoma brucei calpain-like protein, putative 0.0125 0.1193 0.3668
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0034 0.0062 0.0062
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0161 0.1648 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0037 0.0109 0.0057
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0425 0.0425
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0037 0.0109 0.0107
Loa Loa (eye worm) hypothetical protein 0.0039 0.0134 0.0134
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0052 0.0288 0.0287
Loa Loa (eye worm) fibroinase 0.0047 0.0223 0.0223
Echinococcus granulosus chromobox protein 1 0.007 0.0507 0.0505
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0833 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0039 0.0134 0.0132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0288 0.0287
Schistosoma mansoni cathepsin F (C01 family) 0.0039 0.0134 0.0132
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0534 0.1721
Echinococcus granulosus calpain 7 C02 family 0.0125 0.1193 0.1191
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0288 0.0287
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0288 0.0287
Brugia malayi G-protein coupled receptor 0.0052 0.0288 0.0287
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0161 0.1648 0.5183
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0278 0.3094 0.3093
Brugia malayi Cathepsin L-like precursor 0.0047 0.0223 0.0221
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0223 0.0716
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0288 0.0287
Trypanosoma cruzi cysteine proteinase, putative 0.0036 0.0092 0.009
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0109 0.0107
Brugia malayi Cathepsin L-like precursor 0.0047 0.0223 0.0221
Schistosoma mansoni calpain (C02 family) 0.0125 0.1193 0.1191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0288 0.0287
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0288 0.0287
Schistosoma mansoni hypothetical protein 0.0052 0.0288 0.0287
Trypanosoma brucei calpain, putative 0.0037 0.0109 0.0057
Entamoeba histolytica grainin 2 0.0042 0.017 0.1023
Brugia malayi Cathepsin L-like precursor 0.0047 0.0223 0.0221
Brugia malayi G protein-coupled receptor F59B2.13 0.0052 0.0288 0.0287
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0288 0.0287
Echinococcus multilocularis GPCR, family 2 0.0034 0.0062 0.006
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.138 0.1379
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0223 0.0716
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0036 0.0092 0.009
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0223 0.0716
Brugia malayi beta-lactamase 0.0072 0.0534 0.0532
Echinococcus multilocularis somatostatin receptor 0.0052 0.0288 0.0287
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0062 0.006
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0288 0.0287
Loa Loa (eye worm) hypothetical protein 0.0072 0.0534 0.0534
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0052 0.0288 0.0287
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0425 0.0423
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0098 0.0859 0.0859
Leishmania major kinesin, putative 0.0087 0.0727 0.2071
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0275 0.0883
Brugia malayi ORL1-like opioid receptor 0.0052 0.0288 0.0287
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0223 0.0716
Brugia malayi beta-lactamase family protein 0.0072 0.0534 0.0532
Brugia malayi hypothetical protein 0.0052 0.0288 0.0287
Echinococcus multilocularis cathepsin L cysteine protease 0.0047 0.0223 0.0221
Echinococcus granulosus cathepsin l1 0.0039 0.0134 0.0132
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0859 0.5205
Echinococcus granulosus tar DNA binding protein 0.0063 0.0425 0.0423
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0161 0.1648 0.1648
Schistosoma mansoni hypothetical protein 0.004 0.0146 0.0144
Onchocerca volvulus 0.0206 0.2202 1
Schistosoma mansoni cathepsin F (C01 family) 0.0047 0.0223 0.0221
Brugia malayi neuropeptide F receptor 0.0052 0.0288 0.0287
Schistosoma mansoni hypothetical protein 0.0052 0.0288 0.0287
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0036 0.0092 0.009
Entamoeba histolytica hypothetical protein 0.0075 0.057 0.3453
Loa Loa (eye worm) hypothetical protein 0.0243 0.2668 0.2668
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0288 0.0287
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0288 0.0287
Schistosoma mansoni hypothetical protein 0.0034 0.0062 0.006
Schistosoma mansoni amine GPCR 0.0052 0.0288 0.0287
Echinococcus multilocularis sex peptide receptor 0.0052 0.0288 0.0287
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Onchocerca volvulus 0.0072 0.0534 0.2418
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0161 0.1648 0.1646
Echinococcus granulosus fmrfamide receptor 0.0052 0.0288 0.0287
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0833 1 1
Onchocerca volvulus 0.0052 0.0288 0.1302
Echinococcus granulosus g protein coupled receptor 0.0052 0.0288 0.0287
Trichomonas vaginalis calpain, putative 0.0037 0.0109 0.0345
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0288 0.0287
Loa Loa (eye worm) TYRA-2 protein 0.0052 0.0288 0.0288
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0007 0.0005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0288 0.0287
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0161 0.1648 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0052 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0206 0.2202 0.2202
Loa Loa (eye worm) hypothetical protein 0.0331 0.3753 0.3753
Echinococcus granulosus lamin 0.0029 0.0007 0.0005
Trypanosoma brucei Calpain-like protein 1.1 0.0037 0.0109 0.0057
Loa Loa (eye worm) calpain family protein 1 0.0331 0.3753 0.3753
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0534 0.0532
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0288 0.0287
Loa Loa (eye worm) hypothetical protein 0.0042 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0039 0.0127 0.0127
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0052 0.0288 0.0287
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0109 0.0107
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0072 0.0534 0.0534
Entamoeba histolytica calpain family cysteine protease, putative 0.0037 0.0109 0.0649
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0223 0.0438
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0139 0.1372 0.137
Entamoeba histolytica cysteine protease, putative 0.0036 0.0092 0.0545
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0288 0.0287
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0275 0.0883
Onchocerca volvulus 0.0052 0.0288 0.1302
Brugia malayi Serotonin receptor 0.0052 0.0288 0.0287
Schistosoma mansoni immunophilin 0.0139 0.1372 0.137
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0223 0.0716
Schistosoma mansoni biogenic amine receptor 0.0052 0.0288 0.0287
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0288 0.0287
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0052 0.0288 0.0287
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.021 0.0208
Loa Loa (eye worm) hypothetical protein 0.0072 0.0534 0.0534
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.021 0.0208
Plasmodium vivax unspecified product 0.0036 0.0092 0.0545
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0161 0.1648 1
Brugia malayi hypothetical protein 0.0052 0.0288 0.0287
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0052 0.0288 0.0287
Schistosoma mansoni Mername-AA248 (C02 family) 0.0125 0.1193 0.1191
Brugia malayi CHE-14 protein 0.0042 0.0164 0.0163
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Entamoeba histolytica hypothetical protein 0.0075 0.057 0.3453
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0125 0.1193 0.1191
Onchocerca volvulus 0.0072 0.0534 0.2418
Echinococcus granulosus expressed conserved protein 0.0092 0.0785 0.0783
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0223 0.0716
Loa Loa (eye worm) hypothetical protein 0.0072 0.0534 0.0534
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0161 0.1648 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0288 0.0287
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0052 0.0288 0.0288
Echinococcus multilocularis g-protein coupled receptor 0.0052 0.0288 0.0287
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0349 0.398 0.3979
Schistosoma mansoni hypothetical protein 0.0034 0.0062 0.006
Schistosoma mansoni lamin 0.0029 0.0007 0.0005
Echinococcus multilocularis chromobox protein 1 0.007 0.0507 0.0505
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0037 0.0109 0.0107
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0052 0.0288 0.0287
Schistosoma mansoni patched 1 0.0042 0.0164 0.0163
Echinococcus multilocularis cathepsin L 0.0036 0.0092 0.009
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0047 0.0223 0.1345
Schistosoma mansoni immunophilin 0.0161 0.1648 0.1646
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.021 0.021
Leishmania major cathepsin L-like protease 0.0047 0.0223 0.0384
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0052 0.0288 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0223 0.0716
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0288 0.0287
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0052 0.0288 0.0287
Brugia malayi cathepsin L-like precursor 0.0039 0.0134 0.0132
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.021 0.0208
Echinococcus granulosus dro:myosuppressin receptor 0.0052 0.0288 0.0287
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0062 0.006
Loa Loa (eye worm) RNA binding protein 0.0063 0.0425 0.0425
Brugia malayi hypothetical protein 0.0052 0.0288 0.0287
Brugia malayi beta-lactamase family protein 0.0072 0.0534 0.0532
Brugia malayi calpain 5 0.0087 0.0727 0.0725
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Plasmodium falciparum calpain 0.0037 0.0109 0.0649
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0425 0.0423
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0223 0.0716
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0288 0.0287
Echinococcus multilocularis chromobox protein 1 0.007 0.0507 0.0505
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0507 0.0507
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0161 0.1648 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0223 0.0716
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0164 0.0163
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0052 0.0288 0.0287
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0052 0.0288 0.0287
Brugia malayi calpain D 0.0037 0.0109 0.0107
Onchocerca volvulus Cathepsin F homolog 0.0047 0.0223 0.1006
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0037 0.0109 0.0345
Loa Loa (eye worm) hypothetical protein 0.0039 0.0134 0.0134
Brugia malayi Melatonin receptor type 1A 0.0052 0.0288 0.0287
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0109 0.0107
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0288 0.0287
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0288 0.0287
Onchocerca volvulus Neuropeptide F receptor homolog 0.0052 0.0288 0.1302
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0037 0.0109 0.0107
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0833 1 1
Schistosoma mansoni hypothetical protein 0.0034 0.0062 0.006
Leishmania major cathepsin L-like protease 0.0047 0.0223 0.0384
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0161 0.1648 0.1646
Onchocerca volvulus 0.0052 0.0288 0.1302
Schistosoma mansoni opsin-like receptor 0.0052 0.0288 0.0287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0223 0.0438
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Schistosoma mansoni hypothetical protein 0.004 0.0146 0.0144
Schistosoma mansoni lamin 0.0029 0.0007 0.0005
Echinococcus multilocularis neuropeptide FF receptor 2 0.0052 0.0288 0.0287
Toxoplasma gondii hypothetical protein 0.0037 0.0109 0.0345
Loa Loa (eye worm) hypothetical protein 0.0072 0.0534 0.0534
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0052 0.0288 0.0287
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0859 0.0857
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0425 0.0423
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0833 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0223 0.0438
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0223 0.0438
Onchocerca volvulus 0.0052 0.0288 0.1302
Loa Loa (eye worm) hypothetical protein 0.0047 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Giardia lamblia Cathepsin B precursor 0.0278 0.3094 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0052 0.0288 0.0287
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0052 0.0288 0.0288
Echinococcus multilocularis cathepsin b 0.0833 1 1
Brugia malayi MAP kinase sur-1 0.0051 0.0275 0.0273
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0052 0.0288 0.0287
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0425 0.0423
Loa Loa (eye worm) beta-lactamase 0.0072 0.0534 0.0534
Onchocerca volvulus 0.0052 0.0288 0.1302
Schistosoma mansoni cathepsin F (C01 family) 0.0047 0.0223 0.0221
Plasmodium vivax vivapain-1 0.0036 0.0092 0.0545
Schistosoma mansoni biogenic amine receptor 0.0052 0.0288 0.0287
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0052 0.0288 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0047 0.0223 0.0716
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0278 0.3094 0.3093
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0161 0.1648 0.5323
Echinococcus multilocularis neuropeptide s receptor 0.0511 0.5997 0.5996
Echinococcus multilocularis serotonin receptor 0.0052 0.0288 0.0287
Plasmodium vivax vivapain-2 0.0047 0.0223 0.1345
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0036 0.0092 0.009
Echinococcus multilocularis programmed cell death protein 0.0042 0.017 0.0168
Echinococcus multilocularis hypothetical protein 0.0125 0.1193 0.1191
Brugia malayi AKH receptor 0.0052 0.0288 0.0287
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0288 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0134 0.0426
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0349 0.398 0.3979
Brugia malayi hypothetical protein 0.0052 0.0288 0.0287
Echinococcus multilocularis cathepsin L cysteine protease 0.0047 0.0223 0.0221
Echinococcus granulosus 7TM GPCR rhodopsin 0.0052 0.0288 0.0287
Plasmodium vivax vivapain-3 0.0036 0.0092 0.0545
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0036 0.0092 0.009
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0052 0.0288 0.0287
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0109 0.0107
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0037 0.0109 0.0345
Onchocerca volvulus 0.0047 0.0223 0.1006
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0275 0.0273
Trypanosoma brucei calpain, putative 0.0037 0.0109 0.0057
Brugia malayi chromobox protein homolog 3 0.0039 0.0127 0.0125
Echinococcus granulosus serotonin receptor 0.0052 0.0288 0.0287
Echinococcus multilocularis neuropeptide receptor A26 0.0511 0.5997 0.5996
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0223 0.0438
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0125 0.1193 0.1191
Trypanosoma brucei centrin-3 0.0042 0.017 0.0262
Entamoeba histolytica calpain large subunit domain III containing protein 0.0087 0.0727 0.4405
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0534 0.3233
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0161 0.1648 0.1646
Schistosoma mansoni alpha-1 adrenergic receptor 0.0052 0.0288 0.0287
Giardia lamblia Cathepsin B precursor 0.0278 0.3094 1
Entamoeba histolytica cysteine protease, putative 0.0036 0.0092 0.0545
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0037 0.0109 0.0345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0223 0.0716
Trichomonas vaginalis esterase, putative 0.0072 0.0534 0.1721
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0161 0.1648 1
Schistosoma mansoni neuropeptide receptor 0.0052 0.0288 0.0287
Schistosoma mansoni hypothetical protein 0.004 0.0146 0.0144
Brugia malayi Cathepsin L-like precursor 0.0039 0.0134 0.0132
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0288 0.0287
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0288 0.0287
Brugia malayi Dopamine receptor protein 2 0.0052 0.0288 0.0287
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0062 0.006
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0037 0.0109 0.0345
Entamoeba histolytica hypothetical protein 0.0075 0.057 0.3453
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0278 0.3094 1
Entamoeba histolytica cysteine proteinase 2 0.0036 0.0092 0.0545
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0288 0.0287
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0037 0.0109 0.0345
Echinococcus granulosus cathepsin l1 0.0047 0.0223 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0164 0.0525
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0288 0.0287
Schistosoma mansoni immunophilin 0.0161 0.1648 0.1646
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0052 0.0288 0.0287
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0425 0.0423
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.057 0.0568
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0833 1 1
Entamoeba histolytica cysteine protease, putative 0.0036 0.0092 0.0545
Schistosoma mansoni hypothetical protein 0.004 0.0146 0.0144
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0223 0.0221
Loa Loa (eye worm) cathepsin B 0.0278 0.3094 0.3094
Loa Loa (eye worm) FKBP5 protein 0.0161 0.1648 0.1648
Toxoplasma gondii cathepsin CPL 0.0047 0.0223 0.0716
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0275 0.0273
Echinococcus granulosus tachykinin peptides receptor 99D 0.0052 0.0288 0.0287
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0288 0.0287
Brugia malayi RE15519p 0.0052 0.0288 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0223 0.0716
Echinococcus granulosus cathepsin b 0.0833 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0968 0.0968
Onchocerca volvulus 0.0047 0.0223 0.1006
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0288 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0223 0.0716
Entamoeba histolytica cysteine protease, putative 0.0036 0.0092 0.0545
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0534 0.0532
Onchocerca volvulus 0.0031 0.0023 0.0094
Schistosoma mansoni amine GPCR 0.0052 0.0288 0.0287
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0047 0.0223 0.0223
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0288 0.0287
Trypanosoma brucei cysteine peptidase C (CPC) 0.0278 0.3094 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0223 0.0716
Echinococcus granulosus sex peptide receptor 0.0052 0.0288 0.0287
Loa Loa (eye worm) calpain 0.0125 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Echinococcus multilocularis calpain 0.0125 0.1193 0.1191
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0062 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0223 0.0438
Echinococcus granulosus cathepsin L 0.0036 0.0092 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0127 0.0405
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0037 0.0109 0.0107
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0288 0.0288
Schistosoma mansoni myosin xvIII 0.0052 0.0288 0.0287
Onchocerca volvulus 0.0052 0.0288 0.1302
Brugia malayi calpain 5 0.0037 0.0109 0.0107
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Echinococcus granulosus g protein coupled receptor 0.0052 0.0288 0.0287
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0859 0.0857
Brugia malayi intermediate filament protein 0.0029 0.0007 0.0005
Echinococcus multilocularis calpain 5 0.0125 0.1193 0.1191
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0275 0.0273
Entamoeba histolytica hypothetical protein 0.0075 0.057 0.3453
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0534 0.1473
Brugia malayi G-protein coupled receptor 0.0052 0.0288 0.0287
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0037 0.0109 0.0107
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0288 0.0287
Plasmodium vivax calpain, putative 0.0125 0.1193 0.7237
Brugia malayi hypothetical protein 0.0052 0.0288 0.0287
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0425 0.0423
Loa Loa (eye worm) hypothetical protein 0.0029 0.0002 0.0002
Toxoplasma gondii ABC1 family protein 0.0072 0.0534 0.1721
Onchocerca volvulus 0.0047 0.0223 0.1006
Echinococcus granulosus lamin dm0 0.0029 0.0007 0.0005
Brugia malayi hypothetical protein 0.0052 0.0288 0.0287
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0275 0.0883
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0161 0.1648 0.1646
Brugia malayi putative neuropeptide receptor NPR1 0.0052 0.0288 0.0287
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0425 0.0425
Brugia malayi neuropeptide F receptor 0.0052 0.0288 0.0287
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0047 0.0223 0.0221
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0534 0.0532
Echinococcus granulosus neuropeptide receptor A26 0.0511 0.5997 0.5996
Echinococcus multilocularis calpain family protein 1, d 0.0243 0.2668 0.2667
Entamoeba histolytica cysteine protease, putative 0.0036 0.0092 0.0545
Leishmania major cysteine peptidase A (CPA) 0.0047 0.0223 0.0384
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0052 0.0288 0.0287
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0859 0.0857
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0223 0.0716
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0275 0.061
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0037 0.0109 0.0107
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0125 0.1193 0.3668
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.0007
Trypanosoma brucei protein kinase, putative 0.0051 0.0275 0.061
Trypanosoma cruzi cysteine protease, putative 0.0036 0.0092 0.009
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0223 0.0221
Entamoeba histolytica cysteine protease, putative 0.0036 0.0092 0.0545
Loa Loa (eye worm) hypothetical protein 0.0293 0.3287 0.3287
Leishmania major cathepsin L-like protease 0.0047 0.0223 0.0384
Echinococcus multilocularis lamin dm0 0.0029 0.0007 0.0005
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.0092 0.009
Echinococcus granulosus cathepsin L cysteine protease 0.0036 0.0092 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0037 0.0109 0.0057
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0288 0.0287
Echinococcus multilocularis musashi 0.0029 0.0007 0.0005
Brugia malayi follicle stimulating hormone receptor 0.0052 0.0288 0.0287
Plasmodium vivax vivapain-2 0.0047 0.0223 0.1345
Echinococcus multilocularis G protein coupled receptor 139 0.0052 0.0288 0.0287
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0534 0.1721
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0052 0.0288 0.0288
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0161 0.1648 0.1646
Echinococcus multilocularis expressed conserved protein 0.0092 0.0785 0.0783
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0278 0.3094 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0029 0.0002 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0288 0.0287
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0288 0.0287
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0161 0.1648 0.1646
Echinococcus granulosus calpain 0.0125 0.1193 0.1191
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0288 0.0287
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0052 0.0288 0.0288
Onchocerca volvulus Cathepsin L homolog 0.0047 0.0223 0.1006
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Schistosoma mansoni neuropeptide f receptor 76f 0.0052 0.0288 0.0287
Brugia malayi hypothetical protein 0.0052 0.0288 0.0287
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0161 0.1648 0.1646
Trichomonas vaginalis chromobox protein, putative 0.007 0.0507 0.1634
Trichomonas vaginalis calpain, putative 0.0037 0.0109 0.0345
Trypanosoma brucei antigen, putative 0.0125 0.1193 0.3668
Echinococcus multilocularis programmed cell death protein 0.0042 0.017 0.0168
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0275 0.0273
Echinococcus granulosus chromobox protein 1 0.007 0.0507 0.0505
Onchocerca volvulus 0.0052 0.0288 0.1302
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.057 0.0568
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0275 0.0557
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0288 0.0287
Onchocerca volvulus 0.0047 0.0223 0.1006
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0288 0.0287
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0534 0.5
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0037 0.0109 0.0057
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0161 0.1648 0.1646
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.0092 0.009
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0164 0.0737
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0052 0.0288 0.0287
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0288 0.0287
Echinococcus granulosus calpain A 0.0349 0.398 0.3979
Echinococcus multilocularis calpain A 0.0349 0.398 0.3979
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0275 0.0273
Trypanosoma cruzi kinesin, putative 0.0087 0.0727 0.0725
Entamoeba histolytica cysteine protease, putative 0.0036 0.0092 0.0545
Echinococcus granulosus calpain A 0.0125 0.1193 0.1191
Schistosoma mansoni chromobox protein 0.007 0.0507 0.0505
Schistosoma mansoni hypothetical protein 0.0052 0.0288 0.0287
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0275 0.0273
Entamoeba histolytica cysteine protease, putative 0.0036 0.0092 0.0545
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0134 0.0426
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0164 0.0524
Trichomonas vaginalis hypothetical protein 0.0037 0.0109 0.0345
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0288 0.0287
Leishmania major hypothetical protein, conserved 0.0072 0.0534 0.1425
Brugia malayi Heterochromatin protein 1 0.007 0.0507 0.0505
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Mycobacterium leprae Probable lipase LipE 0.0072 0.0534 0.5
Trypanosoma brucei Calpain-like protein 2 0.0037 0.0109 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0223 0.0716
Schistosoma mansoni histamine h1 receptor 0.0052 0.0288 0.0287
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0052 0.0288 0.0287
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0125 0.1193 0.1191
Echinococcus granulosus 7tm_1 domain containing protein 0.0052 0.0288 0.0287
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0288 0.0287
Echinococcus granulosus calpain 5 0.0125 0.1193 0.1191
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0223 0.0221
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0161 0.1648 0.1646
Echinococcus multilocularis cysteine protease 0.0047 0.0223 0.0221
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0223 0.0221
Onchocerca volvulus 0.0039 0.0134 0.0598
Brugia malayi Dopamine receptor protein 1 0.0052 0.0288 0.0287
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0288 0.0287
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0037 0.0109 0.0057
Echinococcus granulosus somatostatin receptor 0.0052 0.0288 0.0287
Schistosoma mansoni amine GPCR 0.0052 0.0288 0.0287
Echinococcus multilocularis cathepsin b 0.0833 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0052 0.0288 0.0287
Schistosoma mansoni neuropeptide receptor 0.0052 0.0288 0.0287
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0534 0.1721
Echinococcus multilocularis protein dispatched 1 0.0048 0.0238 0.0236
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0275 0.0883
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0968 0.0966
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0052 0.0288 0.0287
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0288 0.0287
Onchocerca volvulus 0.0047 0.0223 0.1006
Brugia malayi hypothetical protein 0.0052 0.0288 0.0287
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0288 0.0287
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0062 0.006
Entamoeba histolytica protein kinase, putative 0.0088 0.0733 0.444
Schistosoma mansoni opsin-like receptor 0.0052 0.0288 0.0287
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0125 0.1193 0.1191
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0127 0.0405
Loa Loa (eye worm) hypothetical protein 0.0029 0.0002 0.0002
Toxoplasma gondii cathepsin B 0.0278 0.3094 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0125 0.1193 0.3668
Brugia malayi Serotonin receptor 0.0052 0.0288 0.0287
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0534 0.0532
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0161 0.1648 0.5323
Brugia malayi Tachykinin-like peptides receptor 99D 0.0052 0.0288 0.0287
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0092 0.0545
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0125 0.1193 0.1191
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Echinococcus granulosus geminin 0.0181 0.1899 0.1898
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0125 0.1193 0.1191
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0047 0.0223 0.0223
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.021 0.0208
Echinococcus granulosus allatostatin A receptor 0.0052 0.0288 0.0287
Schistosoma mansoni calpain-2 (C02 family) 0.0037 0.0109 0.0107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0288 0.0287
Echinococcus multilocularis protein patched 0.0042 0.0164 0.0163
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0092 0.0545
Trypanosoma brucei hypothetical protein 0.0037 0.0109 0.0057
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0139 0.1372 0.137
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0062 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0223 0.0716
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0223 0.0438
Leishmania major cathepsin L-like protease 0.0047 0.0223 0.0384
Leishmania major peptidylprolyl isomerase-like protein 0.0161 0.1648 0.5155
Echinococcus granulosus cysteine protease 0.0036 0.0092 0.009
Brugia malayi G protein-coupled receptor 0.0052 0.0288 0.0287
Leishmania major cathepsin L-like protease 0.0047 0.0223 0.0384
Onchocerca volvulus 0.0052 0.0288 0.1302
Schistosoma mansoni neuropeptide receptor 0.0052 0.0288 0.0287
Trypanosoma cruzi kinesin, putative 0.0087 0.0727 0.0725
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0288
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0161 0.1648 0.5183
Trypanosoma cruzi centrin, putative 0.0042 0.017 0.0168
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0125 0.1193 0.3632
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0534 0.1721
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0039 0.0134 0.0134
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0968 0.0966
Loa Loa (eye worm) hypothetical protein 0.0072 0.0534 0.0534
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0125 0.1193 0.1191
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0125 0.1193 0.3632
Echinococcus granulosus orexin receptor type 2 0.0052 0.0288 0.0287
Brugia malayi larval opioid receptor 0.0052 0.0288 0.0287
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0037 0.0109 0.0107
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.021 0.0208
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0288 0.0287
Echinococcus granulosus neuropeptide receptor 0.0052 0.0288 0.0287
Trichomonas vaginalis immunophilin, putative 0.0161 0.1648 0.5323

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) > 10000 nM Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirus ChEMBL. 17822897
Ki (binding) > 10000 nM Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirus ChEMBL. 17822897

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.