TDR Targets

Basic information

Technical information

TDR Targets ID: 809930
Name: 3-(cycloheptylamino)-1-(4-methylphenyl)pyrrol idine-2,5-dione
MW: 300.395 | Formula: C18H24N2O2
H donors: 1 H acceptors: 2 LogP: 3.12 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C1C(NC2CCCCCC2)CC(=O)N1c1ccc(cc1)C
InChi: 1S/C18H24N2O2/c1-13-8-10-15(11-9-13)20-17(21)12-16(18(20)22)19-14-6-4-2-3-5-7-14/h8-11,14,16,19H,2-7,12H2,1H3
InChiKey: RTNUEIYIDUPZIK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(cycloheptylamino)-1-(4-methylphenyl)pyrrolidine-2,5-quinone
6205-16-9
CBMicro_008954
BIM-0008956.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0068	0.0199	0.0199
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0053	0.0044	0.0044
Echinococcus granulosus	cathepsin b	0.0985	1	1
Echinococcus granulosus	calpain 7 C02 family	0.0215	0.1769	0.1769
Brugia malayi	cathepsin L-like precursor	0.0055	0.0063	0.0063
Echinococcus granulosus	cathepsin l1	0.0055	0.0063	0.0063
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0068	0.0199	0.0199
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0053	0.0044	0.0044
Schistosoma mansoni	cathepsin F (C01 family)	0.0068	0.0199	0.0199
Trypanosoma brucei	calpain-like protein, putative	0.0215	0.1769	0.5898
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0068	0.0199	0.0663
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0053	0.0044	0.0044
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0053	0.0044	0.0044
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0199	0.0663
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0985	1	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0053	0.0044	0.0044
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0199	0.0663
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0637	0.6276	0.6276
Leishmania major	cathepsin L-like protease	0.0114	0.0693	0.2198
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0053	0.0044	0.0044
Trypanosoma brucei	Calpain-like protein 2	0.0053	0.0044	0.0145
Onchocerca volvulus		0.0068	0.0199	0.0389
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0215	0.1769	0.1769
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0199	0.0663
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0053	0.0044	0.0044
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0199	0.0663
Giardia lamblia	Cathepsin B precursor	0.033	0.2999	0.5
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0068	0.0199	0.0199
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0053	0.0044	0.0044
Trypanosoma cruzi	cysteine peptidase, putative	0.0114	0.0693	0.0693
Trichomonas vaginalis	calpain, putative	0.0053	0.0044	0.0145
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0053	0.0044	0.0145
Trypanosoma cruzi	kinesin, putative	0.0162	0.1201	0.1201
Leishmania major	kinesin, putative	0.0162	0.1201	0.3915
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0596	0.5842	0.5842
Trypanosoma cruzi	cruzipain precursor, putative	0.0114	0.0693	0.0693
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0199	0.0199
Leishmania major	cathepsin L-like protease	0.0068	0.0199	0.0526
Trypanosoma brucei	antigen, putative	0.0215	0.1769	0.5898
Brugia malayi	calpain D	0.0053	0.0044	0.0044
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0199	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0435	0.4117	0.4091
Toxoplasma gondii	cathepsin B	0.033	0.2999	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0215	0.1769	0.1769
Leishmania major	cathepsin L-like protease	0.0068	0.0199	0.0526
Schistosoma mansoni	calpain-7 (C02 family)	0.0215	0.1769	0.1769
Trypanosoma brucei	calpain-like protein, putative	0.0215	0.1769	0.5898
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0199	0.0663
Entamoeba histolytica	cysteine proteinase, putative	0.0068	0.0199	0.1657
Echinococcus multilocularis	calpain family protein 1, d	0.0435	0.4117	0.4117
Echinococcus multilocularis	programmed cell death protein	0.0059	0.011	0.011
Trypanosoma brucei	caltractin, putative	0.0059	0.011	0.0366
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0053	0.0044	0.0145
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0053	0.0044	0.0145
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0053	0.0044	0.0145
Echinococcus granulosus	calpain 5	0.0215	0.1769	0.1769
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0114	0.0693	0.2311
Echinococcus granulosus	cathepsin b	0.0985	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0985	1	1
Trypanosoma brucei	calpain, putative	0.0053	0.0044	0.0145
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0637	0.6276	0.6276
Trypanosoma brucei	Calpain-like protein 1.1	0.0053	0.0044	0.0145
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0068	0.0199	1
Schistosoma mansoni	calpain C (C02 family)	0.0215	0.1769	0.1769
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0215	0.1769	0.1769
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0199	0.0663
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0199	0.0663
Schistosoma mansoni	cathepsin F (C01 family)	0.0055	0.0063	0.0063
Entamoeba histolytica	grainin 2	0.0059	0.011	0.0914
Onchocerca volvulus		0.0068	0.0199	0.0389
Echinococcus multilocularis	cathepsin L cysteine protease	0.0068	0.0199	0.0199
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0053	0.0044	0.0044
Echinococcus granulosus	cathepsin l1	0.0068	0.0199	0.0199
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0215	0.1769	0.1769
Trypanosoma cruzi	centrin, putative	0.0059	0.011	0.011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0114	0.0693	0.2311
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0068	0.0199	0.0156
Echinococcus multilocularis	calpain	0.0215	0.1769	0.1769
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0053	0.0044	0.0044
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0114	0.0693	0.2311
Onchocerca volvulus		0.0068	0.0199	0.0389
Onchocerca volvulus	Cathepsin L homolog	0.0068	0.0199	0.0389
Entamoeba histolytica	protein kinase, putative	0.0162	0.1201	1
Leishmania major	cathepsin L-like protease	0.0068	0.0199	0.0526
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0053	0.0044	0.0044
Brugia malayi	calpain 5	0.0053	0.0044	0.0044
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0199	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0199	0.0156
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0199	0.0199
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0215	0.1769	0.5898
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0199	0.0663
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0199	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0596	0.5842	0.5824
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0199	0.0663
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0055	0.0063	0.0063
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0068	0.0199	1
Leishmania major	cathepsin L-like protease	0.0114	0.0693	0.2198
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0215	0.1769	0.5838
Trypanosoma brucei	cytoskeleton-associated protein CAP5.5, putative	0.0053	0.0044	0.0145
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0199	0.0663
Onchocerca volvulus		0.0068	0.0199	0.0389
Loa Loa (eye worm)	calpain	0.0215	0.1769	0.1733
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0053	0.0044	0.0145
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0199	0.0663
Onchocerca volvulus	Cathepsin F homolog	0.0068	0.0199	0.0389
Echinococcus multilocularis	cysteine protease	0.0068	0.0199	0.0199
Echinococcus granulosus	calpain A	0.0215	0.1769	0.1769
Plasmodium vivax	vivapain-2	0.0068	0.0199	0.1125
Trypanosoma brucei	cysteine peptidase C (CPC)	0.033	0.2999	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0114	0.0693	0.2311
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0114	0.0693	0.2311
Trypanosoma cruzi	cysteine peptidase, putative	0.0114	0.0693	0.0693
Schistosoma mansoni	cathepsin F (C01 family)	0.0068	0.0199	0.0199
Trypanosoma brucei	centrin-3	0.0059	0.011	0.0366
Echinococcus multilocularis	calpain 5	0.0215	0.1769	0.1769
Schistosoma mansoni	hypothetical protein	0.0053	0.0044	0.0044
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0053	0.0044	0.0044
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0199	0.0663
Loa Loa (eye worm)	ctsf protein	0.0068	0.0199	0.0156
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0215	0.1769	0.1769
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0199	0.0199
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0053	0.0044	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0063	0.002
Giardia lamblia	Cathepsin B precursor	0.033	0.2999	0.5
Echinococcus multilocularis	cathepsin L cysteine protease	0.0068	0.0199	0.0199
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0215	0.1769	0.1769
Echinococcus multilocularis	calpain 7 (C02 family)	0.0215	0.1769	0.1769
Onchocerca volvulus		0.0068	0.0199	0.0389
Toxoplasma gondii	cathepsin CPL	0.0068	0.0199	0.0526
Entamoeba histolytica	calpain family cysteine protease, putative	0.0053	0.0044	0.0363
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0114	0.0693	0.2311
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.033	0.2999	0.2999
Leishmania major	cathepsin L-like protease	0.0068	0.0199	0.0526
Echinococcus multilocularis	cathepsin b	0.0985	1	1
Trypanosoma cruzi	centrin-3	0.0059	0.011	0.011
Trypanosoma brucei	glucosamine 6-phosphate n-acetyltransferase	0.0053	0.0044	0.0145
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0199	0.0199
Entamoeba histolytica	cysteine proteinase, putative	0.0068	0.0199	0.1657
Loa Loa (eye worm)	cathepsin B	0.033	0.2999	0.2968
Echinococcus multilocularis	hypothetical protein	0.0215	0.1769	0.1769
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0114	0.0693	0.2311
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.033	0.2999	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0068	0.0199	0.0663
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0053	0.0044	0.0044
Trypanosoma brucei	calpain-like protein, putative	0.0215	0.1769	0.5898
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0053	0.0044	0.0044
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0199	0.0663
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0199	0.0199
Brugia malayi	Cathepsin L-like precursor	0.0055	0.0063	0.0063
Leishmania major	cysteine peptidase A (CPA)	0.0068	0.0199	0.0526
Onchocerca volvulus	Cathepsin L homolog	0.0068	0.0199	0.0389
Trypanosoma cruzi	kinesin, putative	0.0162	0.1201	0.1201
Trypanosoma brucei	hypothetical protein	0.0053	0.0044	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0985	1	1
Onchocerca volvulus		0.0381	0.3548	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0985	1	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0053	0.0044	0.0044
Leishmania major	cathepsin L-like protease	0.0068	0.0199	0.0526
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0114	0.0693	0.2311
Entamoeba histolytica	cysteine protease, putative	0.0068	0.0199	0.1657
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0199	0.0663
Trypanosoma cruzi	major cysteine proteinase, putative	0.0083	0.0359	0.0359
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0215	0.1769	0.1769
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0637	0.6276	0.6276
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0637	0.6276	0.6276
Loa Loa (eye worm)	calpain family protein 1	0.0435	0.4117	0.4091
Echinococcus multilocularis	programmed cell death protein	0.0059	0.011	0.011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0199	0.0663
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0068	0.0199	0.0156
Onchocerca volvulus		0.0068	0.0199	0.0389
Schistosoma mansoni	calpain-2 (C02 family)	0.0053	0.0044	0.0044
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0053	0.0044	0.0145
Loa Loa (eye worm)	calpain 5	0.0162	0.1201	0.1162
Trypanosoma cruzi	cysteine peptidase, putative	0.0114	0.0693	0.0693
Trypanosoma brucei	kinesin, putative	0.0162	0.1201	0.4003
Trichomonas vaginalis	calcium binding protein, putative	0.0059	0.011	0.0366
Trypanosoma cruzi	conserved protein	0.0053	0.0044	0.0044
Entamoeba histolytica	cysteine proteinase, putative	0.0055	0.0063	0.0527
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0215	0.1769	0.5898
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0068	0.0199	1
Trichomonas vaginalis	calpain, putative	0.0053	0.0044	0.0145
Brugia malayi	Cathepsin L-like precursor	0.0055	0.0063	0.0063
Trypanosoma brucei	Calpain-like protein 1.2	0.0053	0.0044	0.0145
Trichomonas vaginalis	calpain, putative	0.0053	0.0044	0.0145
Trypanosoma brucei	Calpain-like protein CALP1.3	0.0053	0.0044	0.0145
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0053	0.0044	0.0145
Trypanosoma brucei	cysteine peptidase, putative	0.0053	0.0044	0.0145
Echinococcus multilocularis	calpain A	0.0637	0.6281	0.6281
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0053	0.0044	0.0145
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0068	0.0199	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0063	0.002
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0162	0.1201	1
Giardia lamblia	Cathepsin B precursor	0.033	0.2999	0.5
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0053	0.0044	0.0044
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0053	0.0044	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0543	0.5274	0.5253
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0199	0.0663
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0063	0.0211
Leishmania major	cathepsin L-like protease	0.0114	0.0693	0.2198
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0199	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0381	0.3548	0.352
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0053	0.0044	0.0044
Brugia malayi	calpain family protein 1	0.0596	0.5842	0.5842
Loa Loa (eye worm)	calpain family protein 1	0.0596	0.5842	0.5824
Trypanosoma cruzi	centrin, putative	0.0059	0.011	0.011
Trypanosoma brucei	calpain-like protein, putative	0.0215	0.1769	0.5898
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0101	0.0558	0.0558
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0985	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0199	0.0663
Echinococcus multilocularis	cysteine protease	0.0068	0.0199	0.0199
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0215	0.1769	0.1769
Trichomonas vaginalis	calmodulin, putative	0.0059	0.011	0.0366
Plasmodium vivax	calpain, putative	0.0215	0.1769	1
Brugia malayi	calpain 7	0.0215	0.1769	0.1769
Loa Loa (eye worm)	cysteine protease	0.0068	0.0199	0.0156
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0068	0.0199	0.0199
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0215	0.1769	0.5838
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0215	0.1769	0.1769
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0114	0.0693	0.2311
Plasmodium falciparum	calpain	0.0053	0.0044	0.2188
Brugia malayi	calpain family protein 1	0.0596	0.5842	0.5842
Onchocerca volvulus		0.0068	0.0199	0.0389
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0068	0.0199	0.0663
Echinococcus granulosus	programmed cell death protein	0.0059	0.011	0.011
Brugia malayi	Papain family cysteine protease containing protein	0.0068	0.0199	0.0199
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0215	0.1769	0.5838
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0215	0.1769	0.1769
Plasmodium vivax	vivapain-2	0.0068	0.0199	0.1125
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0063	0.002
Echinococcus granulosus	calpain A	0.0637	0.6281	0.6281
Echinococcus granulosus	calpain	0.0215	0.1769	0.1769
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0114	0.0693	0.2311
Trichomonas vaginalis	hypothetical protein	0.0053	0.0044	0.0145
Schistosoma mansoni	calpain-7 (C02 family)	0.0215	0.1769	0.1769
Loa Loa (eye worm)	fibroinase	0.0068	0.0199	0.0156
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0053	0.0044	0.0044
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.033	0.2999	1
Schistosoma mansoni	calpain (C02 family)	0.0215	0.1769	0.1769
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0215	0.1769	0.1769
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0114	0.0693	0.2311
Trypanosoma brucei	calpain, putative	0.0053	0.0044	0.0145
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0985	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0063	0.0211
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0044	0.0145
Echinococcus multilocularis	cathepsin b	0.0985	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.033	0.2999	0.2999
Brugia malayi	calpain 5	0.0162	0.1201	0.1201
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0199	0.0199

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 809930