Detailed information for compound 982049

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 456.578 | Formula: C25H36N4O4
  • H donors: 1 H acceptors: 3 LogP: 2.63 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N1CCN(CC1)CCNC(=O)[C@@H]1CCC(=O)N1C(=O)C1CCCCC1
  • InChi: 1S/C25H36N4O4/c1-33-22-10-6-5-9-20(22)28-17-15-27(16-18-28)14-13-26-24(31)21-11-12-23(30)29(21)25(32)19-7-3-2-4-8-19/h5-6,9-10,19,21H,2-4,7-8,11-18H2,1H3,(H,26,31)/t21-/m0/s1
  • InChiKey: QYNVUDIJSLZKIN-NRFANRHFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 2a (5-HT2a) receptor Starlite/ChEMBL References
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Serotonin 2a (5-HT2a) receptor   471 aa 435 aa 23.0 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Serotonin 2a (5-HT2a) receptor   471 aa 405 aa 25.4 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropeptide F-like receptor 0.0061 0.0237 0.0288
Onchocerca volvulus 0.0061 0.0237 0.0559
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0237 0.024
Echinococcus multilocularis neuropeptide FF receptor 2 0.0061 0.0237 0.0189
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0097 0.0667 0.093
Leishmania major chitinase 0.015 0.1311 0.1828
Schistosoma mansoni g1/s-specific cyclin C 0.0088 0.0566 0.0798
Echinococcus multilocularis hypothetical protein 0.0107 0.0789 0.075
Echinococcus multilocularis dual specificity 0.056 0.6231 0.6287
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0076 0.0419 0.0571
Brugia malayi G protein-coupled receptor 0.0061 0.0237 0.0288
Loa Loa (eye worm) carboxylesterase 0.0092 0.0614 0.0851
Echinococcus granulosus biogenic amine 5HT receptor 0.0326 0.3423 0.3464
Chlamydia trachomatis protoporphyrinogen oxidase 0.0062 0.0243 0.5
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0076 0.0419 0.0571
Echinococcus granulosus casein kinase I alpha 0.0087 0.0549 0.0556
Echinococcus granulosus serine:threonine protein kinase haspin 0.0582 0.6501 0.658
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.011 0.0827 0.1023
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.0877 0.0888
Trichomonas vaginalis CMGC family protein kinase 0.056 0.6231 1
Echinococcus granulosus g protein coupled receptor 0.0061 0.0237 0.024
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0076 0.0419 0.0556
Brugia malayi Dopamine receptor protein 1 0.0462 0.5059 0.7764
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0061 0.0237 0.0189
Toxoplasma gondii histone deacetylase HDAC5 0.01 0.0702 0.1127
Trypanosoma cruzi histone deacetylase, putative 0.01 0.0702 0.0767
Toxoplasma gondii histone deacetylase HDAC3 0.0232 0.2292 0.3678
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Trypanosoma cruzi casein kinase, putative 0.0087 0.0549 0.0512
Loa Loa (eye worm) haspin protein kinase 0.0582 0.6501 0.9745
Toxoplasma gondii histone deacetylase HDAC4 0.01 0.0702 0.1127
Trypanosoma cruzi histone deacetylase, putative 0.0209 0.2014 0.2958
Echinococcus granulosus neuroligin 0.0092 0.0614 0.0622
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Loa Loa (eye worm) hypothetical protein 0.0119 0.093 0.1328
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.056 0.6231 0.9582
Giardia lamblia G2/mitotic-specific cyclin B 0.011 0.0827 0.0967
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0076 0.0419 0.0571
Echinococcus granulosus 7tm_1 domain containing protein 0.0061 0.0237 0.024
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0088 0.0566 0.0524
Schistosoma mansoni hypothetical protein 0.0582 0.6501 1
Echinococcus granulosus casein kinase I delta 0.0087 0.0549 0.0556
Entamoeba histolytica cyclin, putative 0.011 0.0827 0.1255
Schistosoma mansoni histone deacetylase 4 5 0.0209 0.2014 0.3043
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0239 0.2374 0.2402
Echinococcus granulosus somatostatin receptor 0.0061 0.0237 0.024
Onchocerca volvulus Putative endochitinase 0.0169 0.153 0.4449
Schistosoma mansoni amine oxidase 0.0062 0.0243 0.0297
Leishmania major histone deacetylase, putative 0.0232 0.2292 0.3456
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0217 0.0257
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0061 0.0237 0.0288
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0189 0.0213
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0556
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0061 0.0237 0.0288
Brugia malayi hypothetical protein 0.02 0.1904 0.2873
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Entamoeba histolytica protein kinase, putative 0.0106 0.0781 0.1181
Trichomonas vaginalis serine/threonine kinase, putative 0.0121 0.0958 0.1537
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0195 0.0233
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0076 0.0419 0.0375
Toxoplasma gondii histone lysine-specific demethylase 0.0062 0.0243 0.039
Trichomonas vaginalis CMGC family protein kinase 0.0363 0.3866 0.6204
Echinococcus multilocularis G protein coupled receptor 139 0.0061 0.0237 0.0189
Echinococcus granulosus casein kinase I alpha 0.0087 0.0549 0.0556
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0873 1 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0097 0.0667 0.0626
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Entamoeba histolytica chitinase, putative 0.015 0.1311 0.2039
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0237 0.024
Echinococcus multilocularis cyclins 0.0062 0.0248 0.0201
Giardia lamblia Kinase, CK1 Casein kinase 0.0087 0.0549 0.0503
Onchocerca volvulus 0.0092 0.0614 0.1695
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0062 0.0243 0.0297
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0556
Echinococcus granulosus glycine receptor subunit beta 0.0076 0.0419 0.0425
Schistosoma mansoni histone deacetylase hda2 0.01 0.0702 0.1009
Echinococcus granulosus cyclin B3 1 0.0062 0.0248 0.0251
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Echinococcus granulosus Cell division cycle 2 protein kinase 0.0121 0.0958 0.0969
Brugia malayi hypothetical protein 0.0061 0.0237 0.0288
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0076 0.0419 0.0556
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0363 0.3866 0.6204
Echinococcus granulosus peptide allatostatin:somatostatin 0.0061 0.0237 0.024
Echinococcus granulosus histone deacetylase 6 0.0209 0.2014 0.2038
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.0121 0.0958 0.1537
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0076 0.0419 0.0571
Toxoplasma gondii histone deacetylase HDAC1 0.0209 0.2014 0.3232
Echinococcus granulosus histone deacetylase 7 0.0209 0.2014 0.2038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0237 0.0288
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.2258 0.2245
Onchocerca volvulus 0.0234 0.232 0.6826
Echinococcus granulosus cyclins 0.0062 0.0248 0.0251
Onchocerca volvulus 0.0061 0.0237 0.0559
Loa Loa (eye worm) histone deacetylase 7A 0.0209 0.2014 0.2966
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0097 0.0667 0.0675
Brugia malayi hypothetical protein 0.0061 0.0237 0.0288
Brugia malayi Cation transporter family protein 0.0076 0.0419 0.0571
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.1192 0.116
Schistosoma mansoni alpha-1 adrenergic receptor 0.0061 0.0237 0.0288
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Schistosoma mansoni amine GPCR 0.0061 0.0237 0.0288
Echinococcus granulosus glycine receptor subunit beta 0.0076 0.0419 0.0425
Loa Loa (eye worm) neuropeptide F receptor 0.0061 0.0237 0.0281
Brugia malayi Cyclin, N-terminal domain containing protein 0.011 0.0827 0.1202
Trichomonas vaginalis cyclins, putative 0.011 0.0827 0.1327
Trypanosoma cruzi cyclin, putative 0.011 0.0827 0.0975
Brugia malayi excitatory GABA receptor EXP-1A 0.0076 0.0419 0.0571
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0106 0.0781 0.0899
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0667 0.0955
Schistosoma mansoni single-minded 0.0047 0.007 0.003
Loa Loa (eye worm) hypothetical protein 0.0348 0.3681 0.5484
Echinococcus granulosus cyclins 0.0062 0.0248 0.0251
Onchocerca volvulus 0.0061 0.0237 0.0559
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Loa Loa (eye worm) hypothetical protein 0.01 0.0702 0.0983
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0061 0.0237 0.0288
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0237 0.024
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Echinococcus multilocularis histone deacetylase 6 0.0215 0.2086 0.207
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Schistosoma mansoni sodium/chloride dependent transporter 0.0234 0.232 0.3517
Schistosoma mansoni amine GPCR 0.0061 0.0237 0.0288
Echinococcus granulosus cyclin dependent kinase 1 0.0097 0.0667 0.0675
Toxoplasma gondii hypothetical protein 0.0239 0.2374 0.3809
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.0121 0.0958 0.1241
Loa Loa (eye worm) hypothetical protein 0.0092 0.0614 0.0851
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0363 0.3866 0.605
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0781 0.1254
Echinococcus granulosus cyclin b3 0.0062 0.0248 0.0251
Trichomonas vaginalis CMGC family protein kinase 0.0121 0.0958 0.1537
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0061 0.0237 0.0288
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0076 0.0419 0.0375
Brugia malayi GnHR receptor homolog 0.0061 0.0237 0.0288
Echinococcus granulosus cyclins 0.0062 0.0248 0.0251
Giardia lamblia Kinase, CAMK CAMKL 0.0121 0.0958 0.1186
Echinococcus multilocularis glycine receptor subunit beta 0.0076 0.0419 0.0375
Brugia malayi Protein kinase domain containing protein 0.0121 0.0958 0.1406
Schistosoma mansoni biogenic amine receptor 0.0061 0.0237 0.0288
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0322 0.3374 0.502
Echinococcus granulosus neuropeptide Y receptor 0.0061 0.0237 0.024
Brugia malayi Protein kinase domain containing protein 0.0363 0.3866 0.5914
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0556
Brugia malayi cell division control protein 2 homolog 0.0097 0.0667 0.0955
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0061 0.0237 0.0288
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0088 0.0564 0.0775
Echinococcus multilocularis neuroligin 0.0092 0.0614 0.0573
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0061 0.0237 0.0288
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.056 0.6231 1
Trichomonas vaginalis cyclin B, putative 0.011 0.0827 0.1327
Schistosoma mansoni hypothetical protein 0.0061 0.0237 0.0288
Schistosoma mansoni sodium/chloride dependent transporter 0.0054 0.0151 0.0154
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0087 0.0549 0.0512
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0239 0.2374 0.3601
Trichomonas vaginalis histone deacetylase, putative 0.0232 0.2292 0.3678
Echinococcus granulosus histone deacetylase 0.0209 0.2014 0.2038
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0092 0.0614 0.0446
Mycobacterium tuberculosis Possible oxidoreductase 0.0062 0.0243 0.0035
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0556
Echinococcus granulosus Pfam-B_8186 domain containing protein 0.0107 0.0789 0.0798
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0211 0.0247
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0582 0.6501 0.6562
Plasmodium falciparum protein kinase 5 0.0097 0.0667 0.1171
Entamoeba histolytica cell division protein kinase 2, putative 0.0204 0.1952 0.3076
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Entamoeba histolytica protein kinase, putative 0.056 0.6231 1
Brugia malayi Cation transporter family protein 0.0076 0.0419 0.0571
Echinococcus granulosus para nitrobenzyl esterase 0.0092 0.0614 0.0622
Echinococcus granulosus casein kinase i 0.0087 0.0549 0.0556
Loa Loa (eye worm) hypothetical protein 0.0462 0.5059 0.7566
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0582 0.6501 0.6562
Brugia malayi larval opioid receptor 0.0061 0.0237 0.0288
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0234 0.232 0.3517
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0076 0.0419 0.0571
Echinococcus granulosus cyclins 0.0062 0.0248 0.0251
Echinococcus granulosus histone deacetylase 6 0.0209 0.2014 0.2038
Schistosoma mansoni biogenic amine (5HT) receptor 0.0426 0.4621 0.7084
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Onchocerca volvulus Putative endochitinase 0.0169 0.153 0.4449
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0248 0.0399
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0237 0.0288
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Echinococcus multilocularis casein kinase I delta 0.0087 0.0549 0.0507
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0556
Brugia malayi histone deacetylase 1 (HD1) 0.0232 0.2292 0.3474
Mycobacterium tuberculosis Conserved hypothetical protein 0.0062 0.0243 0.0035
Onchocerca volvulus Putative endochitinase 0.0169 0.153 0.4449
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0237 0.0189
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.056 0.6231 0.9337
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.1192 0.1768
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0121 0.0958 0.1194
Schistosoma mansoni hypothetical protein 0.0061 0.0237 0.0288
Trypanosoma cruzi cdc2-related kinase 3 0.0097 0.0667 0.0708
Plasmodium vivax histone deacetylase, putative 0.01 0.0702 0.1816
Entamoeba histolytica protein kinase, putative 0.0456 0.4984 0.7982
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0076 0.0419 0.0425
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0076 0.0419 0.0571
Loa Loa (eye worm) histone deacetylase 1 0.0232 0.2292 0.3385
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0076 0.0419 0.0571
Brugia malayi cyclin-dependent kinase 9 0.0058 0.0195 0.0223
Trichomonas vaginalis cyclin B, putative 0.0062 0.0248 0.0399
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.007 0.003
Entamoeba histolytica cyclin, putative 0.0062 0.0248 0.0319
Loa Loa (eye worm) solute carrier family 6 member 4 0.0234 0.232 0.3427
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0076 0.0419 0.0425
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0106 0.0781 0.1103
Echinococcus multilocularis dual specificity 0.056 0.6231 0.6287
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0189 0.0191
Brugia malayi Protein kinase domain containing protein 0.0456 0.4984 0.7648
Brugia malayi histone deacetylase 3 (HD3) 0.0232 0.2292 0.3474
Brugia malayi GSG2 0.0582 0.6501 1
Echinococcus granulosus tm gpcr rhodopsin 0.0061 0.0237 0.024
Echinococcus granulosus nischarin 0.0205 0.1962 0.1985
Echinococcus multilocularis cyclin 0.0088 0.0566 0.0524
Schistosoma mansoni serine/threonine protein kinase 0.0322 0.3374 0.5152
Loa Loa (eye worm) hypothetical protein 0.0062 0.0243 0.029
Echinococcus granulosus glycine receptor subunit alpha 1 0.0076 0.0419 0.0425
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0217 0.0257
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0061 0.0237 0.024
Trypanosoma cruzi casein kinase, putative 0.0087 0.0549 0.0512
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0092 0.0614 0.0573
Echinococcus granulosus serotonin receptor 0.0061 0.0237 0.024
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0243 0.0628
Echinococcus multilocularis g protein coupled receptor 0.0061 0.0237 0.0189
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0097 0.0667 0.107
Schistosoma mansoni survival motor neuron protein 0.0047 0.0065 0.0022
Echinococcus multilocularis cyclins 0.0062 0.0248 0.0201
Schistosoma mansoni growth hormone secretagogue receptor 0.0061 0.0237 0.0288
Brugia malayi Histone deacetylase family protein 0.0209 0.2014 0.3043
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0363 0.3866 0.5837
Echinococcus granulosus BC026374 protein S09 family 0.0092 0.0614 0.0622
Loa Loa (eye worm) hypothetical protein 0.0234 0.232 0.3427
Trichomonas vaginalis CMGC family protein kinase 0.056 0.6231 1
Trichomonas vaginalis CMGC family protein kinase 0.056 0.6231 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Brugia malayi amine oxidase, flavin-containing family protein 0.0062 0.0243 0.0297
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0076 0.0419 0.0571
Trichomonas vaginalis cyclin B, putative 0.011 0.0827 0.1327
Trypanosoma cruzi CYC2-like cyclin, putative 0.011 0.0827 0.0975
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0061 0.0237 0.0189
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0217 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0237 0.024
Trichomonas vaginalis cyclin B3, putative 0.0062 0.0248 0.0399
Leishmania major histone deacetylase, putative 0.0232 0.2292 0.3456
Schistosoma mansoni protein kinase 0.0121 0.0958 0.1406
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0456 0.4984 0.7917
Trichomonas vaginalis CK1 family protein kinase 0.0087 0.0549 0.0882
Trichomonas vaginalis cyclins, putative 0.011 0.0827 0.1327
Trichomonas vaginalis cyclin B, putative 0.011 0.0827 0.1327
Trichomonas vaginalis histone deacetylase, putative 0.0232 0.2292 0.3678
Trichomonas vaginalis spcc417.12 protein, putative 0.0092 0.0614 0.0986
Loa Loa (eye worm) hypothetical protein 0.0128 0.1045 0.1502
Leishmania major histone deacetylase, putative 0.0209 0.2014 0.2995
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0237 0.024
Onchocerca volvulus 0.0076 0.0419 0.1108
Giardia lamblia Kinase, CMGC CLK 0.0363 0.3866 0.6046
Onchocerca volvulus 0.0092 0.0614 0.1695
Echinococcus granulosus lysine specific histone demethylase 1A 0.0062 0.0243 0.0246
Echinococcus multilocularis cyclin dependent kinase 1 0.0097 0.0667 0.0626
Plasmodium vivax histone deacetylase 2, putative 0.0209 0.2014 0.521
Echinococcus multilocularis dual specificity 0.0456 0.4984 0.5018
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0061 0.0237 0.0281
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0958 0.1537
Giardia lamblia Kinase, CMGC GSK 0.0106 0.0781 0.0891
Trichomonas vaginalis CMGC family protein kinase 0.0121 0.0958 0.1537
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Loa Loa (eye worm) hypothetical protein 0.0083 0.0498 0.0675
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0348 0.3681 0.5628
Echinococcus granulosus carboxylesterase 5A 0.0547 0.6077 0.6151
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Trichomonas vaginalis CMGC family protein kinase 0.056 0.6231 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0237 0.0189
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0547 0.6077 0.9343
Plasmodium falciparum conserved protein, unknown function 0.0239 0.2374 0.5882
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0958 0.1537
Trichomonas vaginalis histone deacetylase, putative 0.0232 0.2292 0.3678
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Brugia malayi intracellular kinase 0.0106 0.0781 0.1132
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0189 0.0213
Trypanosoma cruzi casein kinase, putative 0.0087 0.0549 0.0512
Brugia malayi hypothetical protein 0.0061 0.0237 0.0288
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0061 0.0237 0.0189
Brugia malayi hypothetical protein 0.0061 0.0237 0.0288
Mycobacterium ulcerans chitinase/cellulase 0.0128 0.1045 0.0852
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0062 0.0243 0.0297
Onchocerca volvulus 0.0061 0.0237 0.0559
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0061 0.0237 0.0189
Entamoeba histolytica protein kinase domain containing protein 0.056 0.6231 1
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0087 0.0549 0.0753
Echinococcus multilocularis g protein coupled receptor 0.0061 0.0237 0.0189
Echinococcus multilocularis cyclin dependent kinase 9 0.0058 0.0195 0.0147
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0217 0.001
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Loa Loa (eye worm) hypothetical protein 0.0092 0.0614 0.0851
Onchocerca volvulus 0.0061 0.0237 0.0559
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0076 0.0419 0.0571
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0237 0.0288
Onchocerca volvulus 0.0062 0.0243 0.0577
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0061 0.0237 0.0281
Echinococcus granulosus dual specificity protein kinase clk2 0.0363 0.3866 0.3912
Echinococcus granulosus cyclin 0.0088 0.0566 0.0573
Loa Loa (eye worm) carboxylesterase 0.0092 0.0614 0.0851
Brugia malayi Cyclin C 0.0088 0.0566 0.0798
Trypanosoma brucei histone deacetylase 1 0.0232 0.2292 0.3066
Onchocerca volvulus 0.0061 0.0237 0.0559
Loa Loa (eye worm) hypothetical protein 0.0239 0.2374 0.3509
Onchocerca volvulus 0.0076 0.0419 0.1108
Echinococcus granulosus acetylcholinesterase 0.0547 0.6077 0.6151
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0781 0.1254
Schistosoma mansoni myosin xvIII 0.0061 0.0237 0.0288
Brugia malayi hypothetical protein 0.0582 0.6501 1
Echinococcus multilocularis histone deacetylase 6 0.0209 0.2014 0.1997
Echinococcus multilocularis BC026374 protein (S09 family) 0.0092 0.0614 0.0573
Entamoeba histolytica hypothetical protein 0.0107 0.0789 0.1193
Onchocerca volvulus 0.0047 0.0065 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0363 0.3866 0.5914
Onchocerca volvulus 0.0092 0.0614 0.1695
Entamoeba histolytica histone deacetylase, putative 0.0232 0.2292 0.3625
Brugia malayi neuropeptide F receptor 0.0061 0.0237 0.0288
Schistosoma mansoni lipoxygenase 0.008 0.0464 0.064
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0106 0.0781 0.0947
Schistosoma mansoni histone deacetylase 4 5 0.0209 0.2014 0.3043
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0061 0.0237 0.0189
Schistosoma mansoni hypothetical protein 0.0047 0.0065 0.0022
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0121 0.0958 0.2477
Loa Loa (eye worm) microfilarial chitinase 0.0146 0.1263 0.1831
Brugia malayi PAS domain containing protein 0.0047 0.007 0.003
Entamoeba histolytica hypothetical protein 0.0456 0.4984 0.7982
Trichomonas vaginalis cyclin D, putative 0.0062 0.0248 0.0399
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0076 0.0419 0.0556
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0322 0.3374 1
Plasmodium vivax protein kinase Crk2 0.0097 0.0667 0.1725
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Leishmania major histone deacetylase, putative 0.0209 0.2014 0.2995
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0211 0.0247
Loa Loa (eye worm) hypothetical protein 0.0239 0.2374 0.3509
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0076 0.0419 0.0425
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0363 0.3866 0.605
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0556
Echinococcus granulosus neuropeptide receptor 0.0061 0.0237 0.024
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0322 0.3374 0.3381
Echinococcus granulosus g-protein coupled receptor 0.0061 0.0237 0.024
Echinococcus granulosus histone deacetylase 1 0.0232 0.2292 0.2319
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0556
Loa Loa (eye worm) hypothetical protein 0.0442 0.4815 0.7197
Loa Loa (eye worm) hypothetical protein 0.02 0.1904 0.2799
Plasmodium falciparum glycogen synthase kinase 3 0.0106 0.0781 0.1486
Schistosoma mansoni cyclin B 0.011 0.0827 0.1202
Loa Loa (eye worm) hypothetical protein 0.0234 0.232 0.3427
Entamoeba histolytica cell division protein kinase 2, putative 0.0097 0.0667 0.0996
Echinococcus multilocularis casein kinase I delta 0.0087 0.0549 0.0507
Echinococcus granulosus 7TM GPCR rhodopsin 0.0061 0.0237 0.024
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0076 0.0419 0.0571
Loa Loa (eye worm) hypothetical protein 0.0442 0.4815 0.7197
Schistosoma mansoni amine GPCR 0.0061 0.0237 0.0288
Echinococcus multilocularis casein kinase I alpha 0.0087 0.0549 0.0507
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0076 0.0419 0.0375
Echinococcus multilocularis cyclins 0.0062 0.0248 0.0201
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0237 0.0288
Echinococcus multilocularis dro:myosuppressin receptor 0.0061 0.0237 0.0189
Plasmodium falciparum protein serine/threonine kinase-1 0.0363 0.3866 1
Trichomonas vaginalis cyclin B, putative 0.011 0.0827 0.1327
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0076 0.0419 0.0571
Loa Loa (eye worm) hypothetical protein 0.0062 0.0243 0.029
Brugia malayi Carboxylesterase family protein 0.0547 0.6077 0.9343
Brugia malayi sulfakinin receptor protein 0.0061 0.0237 0.0288
Mycobacterium tuberculosis Possible chitinase 0.0128 0.1045 0.0922
Trypanosoma cruzi casein kinase, putative 0.0087 0.0549 0.0512
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0076 0.0419 0.0425
Loa Loa (eye worm) hypothetical protein 0.0312 0.3251 0.4834
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0061 0.0237 0.0189
Entamoeba histolytica protein kinase domain containing protein 0.0121 0.0958 0.1467
Echinococcus multilocularis serotonin receptor 0.0326 0.3423 0.343
Brugia malayi hypothetical protein 0.0061 0.0237 0.0288
Brugia malayi Protein kinase domain containing protein 0.0097 0.0667 0.0955
Entamoeba histolytica protein kinase, putative 0.0456 0.4984 0.7982
Schistosoma mansoni opsin-like receptor 0.0061 0.0237 0.0288
Echinococcus granulosus hypothetical protein 0.0349 0.3697 0.3741
Giardia lamblia Kinase, CMGC DYRK 0.056 0.6231 1
Echinococcus granulosus histone deacetylase 3 0.0232 0.2292 0.2319
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0106 0.0781 0.1132
Onchocerca volvulus 0.0061 0.0237 0.0559
Echinococcus multilocularis g protein coupled receptor 0.0061 0.0237 0.0189
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0211 0.0338
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0322 0.3374 0.3415
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0076 0.0419 0.0571
Loa Loa (eye worm) serotonin transporter b 0.0234 0.232 0.3427
Loa Loa (eye worm) melatonin receptor type 1A 0.0061 0.0237 0.0281
Trypanosoma cruzi cyclin, putative 0.011 0.0827 0.0975
Schistosoma mansoni acetylcholinesterase 0.0092 0.0614 0.0873
Loa Loa (eye worm) G-protein coupled receptor 0.0061 0.0237 0.0281
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0092 0.0614 0.0873
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0076 0.0419 0.0571
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0237 0.0288
Loa Loa (eye worm) hypothetical protein 0.011 0.0827 0.1172
Echinococcus multilocularis neuropeptide receptor 0.0061 0.0237 0.0189
Entamoeba histolytica protein kinase domain containing protein 0.0106 0.0781 0.1181
Brugia malayi Cyclin, N-terminal domain containing protein 0.017 0.1544 0.2314
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0239 0.2374 0.2363
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.0877 0.084
Trypanosoma brucei protein kinase, putative 0.0106 0.0781 0.0408
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0092 0.0614 0.0622
Mycobacterium tuberculosis Carboxylesterase LipT 0.0092 0.0614 0.0446
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0812 0.9261 1
Brugia malayi Histone deacetylase 1 0.0232 0.2292 0.3474
Brugia malayi endochitinase 0.015 0.1311 0.1954
Onchocerca volvulus 0.0061 0.0237 0.0559
Loa Loa (eye worm) acetyltransferase 0.014 0.1192 0.1723
Schistosoma mansoni amine oxidase 0.0062 0.0243 0.0297
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0667 0.107
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0073 0.038 0.023
Loa Loa (eye worm) cyclin C 0.0088 0.0566 0.0777
Brugia malayi jmjC domain containing protein 0.0057 0.0189 0.0213
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0426 0.4621 0.4649
Echinococcus granulosus casein kinase I alpha 0.0087 0.0549 0.0556
Echinococcus multilocularis 0.0349 0.3697 0.3709
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.1144 0.1158
Onchocerca volvulus 0.0076 0.0419 0.1108
Brugia malayi Dopamine receptor protein 2 0.0061 0.0237 0.0288
Trichomonas vaginalis protein kinase atmrk1, putative 0.0121 0.0958 0.1537
Brugia malayi putative neuropeptide receptor NPR1 0.0061 0.0237 0.0288
Trypanosoma cruzi cdc2-related kinase 1 0.0097 0.0667 0.0708
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0322 0.3374 0.5152
Trypanosoma cruzi histone deacetylase, putative 0.01 0.0702 0.0767
Trypanosoma cruzi cdc2-related kinase 1 0.0097 0.0667 0.0708
Schistosoma mansoni nAChR subunit 0.0076 0.0419 0.0571
Plasmodium vivax histone deacetylase 1, putative 0.0232 0.2292 0.5928
Schistosoma mansoni opsin-like receptor 0.0061 0.0237 0.0288
Echinococcus multilocularis cyclin B3 1 0.0062 0.0248 0.0201
Echinococcus multilocularis histone deacetylase 7 0.0209 0.2014 0.1997
Echinococcus granulosus serine:threonine protein kinase NLK 0.0121 0.0958 0.0969
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0061 0.0237 0.0288
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0076 0.0419 0.0571
Loa Loa (eye worm) hypothetical protein 0.0158 0.1404 0.2044
Schistosoma mansoni histone deacetylase hda2 0.0215 0.2086 0.3155
Loa Loa (eye worm) hypothetical protein 0.0062 0.0243 0.029
Brugia malayi hypothetical protein 0.0061 0.0237 0.0288
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0097 0.0667 0.093
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0076 0.0419 0.0571
Brugia malayi SWIRM domain containing protein 0.0062 0.0243 0.0297
Mycobacterium ulcerans carboxylesterase, LipT 0.0092 0.0614 0.0412
Echinococcus granulosus serotonin transporter 0.0234 0.232 0.2348
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0958 0.1537
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Echinococcus granulosus dual specificity 0.056 0.6231 0.6307
Onchocerca volvulus 0.0061 0.0237 0.0559
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0061 0.0237 0.0288
Echinococcus granulosus dual specificity 0.0456 0.4984 0.5044
Schistosoma mansoni protein kinase 0.0087 0.0549 0.0772
Loa Loa (eye worm) chitinase I 0.015 0.1311 0.1904
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0076 0.0419 0.0571
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0121 0.0958 0.1194
Trichomonas vaginalis CMGC family protein kinase 0.056 0.6231 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0076 0.0419 0.0375
Schistosoma mansoni serine/threonine kinase 0.0121 0.0958 0.1406
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Trypanosoma brucei histone deacetylase 2 0.01 0.0702 0.0269
Echinococcus granulosus orexin receptor type 2 0.0061 0.0237 0.024
Echinococcus multilocularis carboxylesterase 5A 0.0547 0.6077 0.6131
Trichomonas vaginalis cyclins, putative 0.011 0.0827 0.1327
Loa Loa (eye worm) hypothetical protein 0.0348 0.3681 0.5484
Echinococcus multilocularis g-protein coupled receptor 0.0061 0.0237 0.0189
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Loa Loa (eye worm) hypothetical protein 0.0092 0.0614 0.0851
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0556
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Echinococcus granulosus serine:threonine protein kinase haspin 0.0582 0.6501 0.658
Schistosoma mansoni biogenic amine (5HT) receptor 0.0326 0.3423 0.5227
Brugia malayi Carboxylesterase family protein 0.0092 0.0614 0.0873
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0237 0.0288
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0121 0.0958 0.0922
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0556
Echinococcus multilocularis neuropeptides capa receptor 0.0061 0.0237 0.0189
Brugia malayi Carboxylesterase family protein 0.0547 0.6077 0.9343
Loa Loa (eye worm) hypothetical protein 0.0115 0.0888 0.1264
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0076 0.0419 0.0571
Echinococcus multilocularis cyclin dependent kinase 7 0.0088 0.0564 0.0522
Echinococcus granulosus sex peptide receptor 0.0061 0.0237 0.024
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0456 0.4984 0.7453
Brugia malayi G-protein coupled receptor 0.0061 0.0237 0.0288
Entamoeba histolytica cyclin family protein 0.0062 0.0248 0.0319
Brugia malayi Cyclin, N-terminal domain containing protein 0.015 0.1304 0.1942
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0237 0.0189
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Schistosoma mansoni cyclins 0.0062 0.0248 0.0306
Schistosoma mansoni neuropeptide receptor 0.0061 0.0237 0.0288
Loa Loa (eye worm) hypothetical protein 0.0062 0.0243 0.029
Loa Loa (eye worm) hypothetical protein 0.0462 0.5059 0.7566
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Echinococcus granulosus neuropeptide receptor 0.0061 0.0237 0.024
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0958 0.1537
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0556
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0076 0.0419 0.0571
Trypanosoma brucei protein kinase, putative 0.0121 0.0958 0.0719
Leishmania major UDP-galactopyranose mutase 0.0062 0.0243 0.0053
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0061 0.0237 0.0288
Echinococcus granulosus G2:mitotic specific cyclin B3 0.017 0.1544 0.1563
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0076 0.0419 0.0375
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0076 0.0419 0.0375
Echinococcus multilocularis glycine receptor subunit beta 0.0076 0.0419 0.0375
Entamoeba histolytica cyclin family protein 0.0062 0.0248 0.0319
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0061 0.0237 0.0288
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0556
Loa Loa (eye worm) hypothetical protein 0.011 0.0827 0.1172
Mycobacterium ulcerans oxidoreductase 0.0062 0.0243 0.0033
Mycobacterium ulcerans chitinase/cellulase 0.0128 0.1045 0.0852
Loa Loa (eye worm) G-protein coupled receptor 0.0061 0.0237 0.0281
Onchocerca volvulus 0.0061 0.0237 0.0559
Echinococcus granulosus cyclin dependent kinase 0.0097 0.0667 0.0675
Loa Loa (eye worm) histone deacetylase 11 0.01 0.0702 0.0983
Onchocerca volvulus 0.0061 0.0237 0.0559
Echinococcus multilocularis cyclins 0.0062 0.0248 0.0201
Schistosoma mansoni amine GPCR 0.0222 0.2166 0.3278
Echinococcus granulosus glycine receptor subunit alpha 1 0.0076 0.0419 0.0425
Schistosoma mansoni amine GPCR 0.0061 0.0237 0.0288
Brugia malayi AKH receptor 0.0061 0.0237 0.0288
Echinococcus granulosus g protein coupled receptor 0.0061 0.0237 0.024
Plasmodium falciparum casein kinase 1 0.0087 0.0549 0.0846
Echinococcus multilocularis para nitrobenzyl esterase 0.0092 0.0614 0.0573
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0076 0.0419 0.0375
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0248 0.2484 0.2514
Echinococcus multilocularis nischarin 0.0205 0.1962 0.1944
Echinococcus granulosus glycine receptor subunit alpha 1 0.0076 0.0419 0.0425
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0556
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0363 0.3866 0.605
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0065 0.0022
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0232 0.2292 0.3678
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0243 0.0628
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0076 0.0419 0.0425
Trypanosoma cruzi cyclin 6, putative 0.011 0.0827 0.0975
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0667 0.107
Onchocerca volvulus 0.0061 0.0237 0.0559
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0217 0.0219
Leishmania major casein kinase, putative 0.0087 0.0549 0.0562
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0061 0.0237 0.0189
Brugia malayi follicle stimulating hormone receptor 0.0061 0.0237 0.0288
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0363 0.3866 0.5763
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Loa Loa (eye worm) hypothetical protein 0.0062 0.0243 0.029
Brugia malayi hypothetical protein 0.0062 0.0243 0.0297
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0189 0.014
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Loa Loa (eye worm) ACC-1 protein 0.0076 0.0419 0.0556
Loa Loa (eye worm) hypothetical protein 0.0048 0.0082 0.0047
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0097 0.0667 0.0758
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0061 0.0237 0.0281
Loa Loa (eye worm) haspin protein kinase 0.0582 0.6501 0.9745
Brugia malayi casein kinase 1, delta 0.0087 0.0549 0.0772
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0121 0.0958 0.2477
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Trichomonas vaginalis histone deacetylase, putative 0.0232 0.2292 0.3678
Loa Loa (eye worm) hypothetical protein 0.0248 0.2484 0.3675
Trypanosoma brucei mitotic cyclin 6 0.011 0.0827 0.0488
Plasmodium vivax casein kinase 1, putative 0.0087 0.0549 0.1421
Brugia malayi hypothetical protein 0.0092 0.0614 0.0873
Brugia malayi cyclin-dependent kinase 7 homolog 0.0195 0.1849 0.2788
Onchocerca volvulus Nischarin homolog 0.02 0.1904 0.5576
Echinococcus granulosus neuropeptide receptor A26 0.0061 0.0237 0.024
Echinococcus multilocularis neuropeptide Y receptor 0.0061 0.0237 0.0189
Echinococcus granulosus neuropeptide Y receptor 0.0061 0.0237 0.024
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0076 0.0419 0.0425
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.056 0.6231 1
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0958 0.1537
Echinococcus multilocularis cyclins 0.0062 0.0248 0.0201
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0076 0.0419 0.0375
Schistosoma mansoni neuropeptide receptor 0.0061 0.0237 0.0288
Brugia malayi Cation transporter family protein 0.0076 0.0419 0.0571
Brugia malayi Melatonin receptor type 1A 0.0061 0.0237 0.0288
Schistosoma mansoni kinase 0.0058 0.0195 0.0223
Onchocerca volvulus Neuropeptide F receptor homolog 0.0061 0.0237 0.0559
Schistosoma mansoni nAChR subunit 0.0076 0.0419 0.0571
Echinococcus multilocularis casein kinase i 0.0087 0.0549 0.0507
Echinococcus granulosus cyclin dependent kinase 9 0.0164 0.148 0.1498
Echinococcus multilocularis neuropeptide s receptor 0.0061 0.0237 0.0189
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Giardia lamblia Kinase, CMGC GSK 0.0106 0.0781 0.0891
Loa Loa (eye worm) TYRA-2 protein 0.0061 0.0237 0.0281
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0248 0.2484 0.3772
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0092 0.0614 0.0446
Echinococcus multilocularis cyclin dependent kinase 9 0.0164 0.148 0.1454
Brugia malayi hypothetical protein 0.0229 0.2258 0.3421
Echinococcus multilocularis protoporphyrinogen oxidase 0.0062 0.0243 0.0195
Brugia malayi hypothetical protein 0.0061 0.0237 0.0288
Brugia malayi Protein kinase domain containing protein 0.0322 0.3374 0.5152
Onchocerca volvulus 0.0061 0.0237 0.0559
Entamoeba histolytica casein kinase, putative 0.0087 0.0549 0.0806
Echinococcus granulosus cyclin dependent kinase 9 0.0058 0.0195 0.0198
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0087 0.0549 0.0753
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0237 0.024
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0061 0.0237 0.024
Onchocerca volvulus 0.0106 0.0781 0.2197
Schistosoma mansoni gliotactin 0.0092 0.0614 0.0873
Trypanosoma brucei cdc2-related kinase 3 0.0097 0.0667 0.0207
Plasmodium vivax glycogen synthase kinase 3, putative 0.0106 0.0781 0.2021
Echinococcus granulosus nAChR subunit 0.0076 0.0419 0.0425
Echinococcus multilocularis neuropeptide receptor A26 0.0061 0.0237 0.0189
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0248 0.2484 0.2475
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0061 0.0237 0.0281
Schistosoma mansoni BC026374 protein (S09 family) 0.0092 0.0614 0.0873
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.1257 0.1822
Echinococcus granulosus hypothetical protein 0.0061 0.0237 0.024
Trypanosoma cruzi casein kinase, putative 0.0087 0.0549 0.0512
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Echinococcus multilocularis casein kinase I alpha 0.0087 0.0549 0.0507
Loa Loa (eye worm) norepinephrine transporter 0.0234 0.232 0.3427
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0061 0.0237 0.0189
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0076 0.0419 0.0556
Plasmodium falciparum histone deacetylase 1 0.0232 0.2292 0.5655
Schistosoma mansoni hypothetical protein 0.0061 0.0237 0.0288
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0106 0.0781 0.0743
Loa Loa (eye worm) hypothetical protein 0.0229 0.2258 0.3333
Onchocerca volvulus 0.0092 0.0614 0.1695
Echinococcus granulosus biogenic amine 5HT receptor 0.0426 0.4621 0.4676
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.1192 0.1768
Brugia malayi hypoxia-induced factor 1 0.0146 0.1257 0.187
Echinococcus multilocularis histone deacetylase 8 0.01 0.0702 0.0662
Trypanosoma cruzi cdc2-related kinase 3 0.0097 0.0667 0.0708
Echinococcus multilocularis histone deacetylase 3 0.0232 0.2292 0.2279
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0106 0.0781 0.1254
Onchocerca volvulus 0.0061 0.0237 0.0559
Onchocerca volvulus 0.0092 0.0614 0.1695
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0062 0.0243 0.039
Brugia malayi Cell division protein kinase 2 0.0121 0.0958 0.1406
Echinococcus granulosus casein kinase I delta 0.0087 0.0549 0.0556
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Echinococcus multilocularis neuropeptide receptor 0.0061 0.0237 0.0189
Echinococcus multilocularis cyclin B 0.011 0.0827 0.0789
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0062 0.0243 0.5
Schistosoma mansoni hypothetical protein 0.0107 0.0789 0.1143
Echinococcus granulosus neuropeptide s receptor 0.0061 0.0237 0.024
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0061 0.0237 0.024
Schistosoma mansoni neuropeptide F-like receptor 0.0061 0.0237 0.0288
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0076 0.0419 0.0425
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0061 0.0237 0.0189
Trichomonas vaginalis histone deacetylase, putative 0.0232 0.2292 0.3678
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0061 0.0237 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0237 0.0189
Brugia malayi Serotonin receptor 0.0507 0.5595 0.8594
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0189 0.0191
Plasmodium falciparum histone deacetylase 2 0.0209 0.2014 0.4889
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Trichomonas vaginalis cyclin A, putative 0.011 0.0827 0.1327
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Echinococcus granulosus tm gpcr rhodopsin 0.0061 0.0237 0.024
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0556
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0061 0.0237 0.0288
Brugia malayi G protein-coupled receptor F59B2.13 0.0061 0.0237 0.0288
Mycobacterium ulcerans monoamine oxidase 0.0062 0.0243 0.0033
Echinococcus granulosus serine:threonine protein kinase haspin 0.0582 0.6501 0.658
Loa Loa (eye worm) neuropeptide F receptor 0.0061 0.0237 0.0281
Echinococcus multilocularis histone deacetylase 6 0.0209 0.2014 0.1997
Echinococcus multilocularis cyclin b3 0.0062 0.0248 0.0201
Loa Loa (eye worm) hypothetical protein 0.0326 0.3423 0.5093
Brugia malayi Tachykinin-like peptides receptor 99D 0.0061 0.0237 0.0288
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0564 0.0795
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0456 0.4984 0.7917
Brugia malayi Histone deacetylase family protein 0.0209 0.2014 0.3043
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0232 0.2292 0.3678
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0076 0.0419 0.0556
Toxoplasma gondii histone deacetylase HDAC2 0.0232 0.2292 0.3678
Loa Loa (eye worm) hypothetical protein 0.0092 0.0614 0.0851
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Echinococcus multilocularis fmrfamide receptor 0.0061 0.0237 0.0189
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0092 0.0614 0.0986
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0076 0.0419 0.0375
Schistosoma mansoni serine/threonine protein kinase 0.0363 0.3866 0.5914
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0348 0.3681 0.5628
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0189 0.0208
Brugia malayi casein kinase I 0.0087 0.0549 0.0772
Brugia malayi RE15519p 0.0061 0.0237 0.0288
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.056 0.6231 1
Loa Loa (eye worm) histone deacetylase 3 0.0232 0.2292 0.3385
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0237 0.0189
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Onchocerca volvulus 0.0239 0.2374 0.6989
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Echinococcus multilocularis neuropeptides capa receptor 0.0061 0.0237 0.0189
Loa Loa (eye worm) hypothetical protein 0.0326 0.3423 0.5093
Onchocerca volvulus 0.0076 0.0419 0.1108
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0549 0.0772
Schistosoma mansoni nAChR subunit 0.0076 0.0419 0.0571
Echinococcus granulosus cyclin B 0.011 0.0827 0.0837
Onchocerca volvulus 0.011 0.0827 0.2334
Trichomonas vaginalis cyclins, putative 0.0071 0.0356 0.0572
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0667 0.107
Echinococcus multilocularis acetylcholinesterase 0.0547 0.6077 0.6131
Plasmodium falciparum cyclin 0.0062 0.0248 0.0015
Loa Loa (eye worm) cyclin domain-containing protein 0.015 0.1304 0.1892
Echinococcus multilocularis cyclin dependent kinase 0.0097 0.0667 0.0626
Mycobacterium ulcerans dehydrogenase 0.0062 0.0243 0.0033
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Loa Loa (eye worm) hypothetical protein 0.0092 0.0614 0.0851
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Echinococcus granulosus G protein coupled receptor 139 0.0061 0.0237 0.024
Toxoplasma gondii casein kinase I 0.0087 0.0549 0.0882
Echinococcus granulosus acetylcholinesterase 0.0547 0.6077 0.6151
Brugia malayi G-protein coupled receptor 0.0061 0.0237 0.0288
Loa Loa (eye worm) hypothetical protein 0.0062 0.0243 0.029
Plasmodium vivax hypothetical protein, conserved 0.0239 0.2374 0.6141
Entamoeba histolytica casein kinase 1, putative 0.0087 0.0549 0.0806
Onchocerca volvulus Putative nachr subunit 0.0076 0.0419 0.1108
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0061 0.0237 0.0288
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0237 0.0288
Loa Loa (eye worm) LGC-31 protein 0.0076 0.0419 0.0556
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0556
Brugia malayi Serotonin receptor 0.0061 0.0237 0.0288
Loa Loa (eye worm) cyclin domain-containing protein 0.017 0.1544 0.2255
Schistosoma mansoni adenoreceptor 0.0061 0.0237 0.0288
Plasmodium falciparum MO15-related protein kinase 0.0121 0.0958 0.1973
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0062 0.0243 0.0628
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0363 0.3866 0.605
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0097 0.0667 0.093
Echinococcus granulosus tm gpcr rhodopsin 0.0863 0.9881 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0061 0.0237 0.0559
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0121 0.0958 0.1194
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0217 0.0006
Schistosoma mansoni cyclin B3 0.017 0.1544 0.2314
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.2258 0.2285
Echinococcus granulosus protein kinase shaggy 0.0106 0.0781 0.0791
Entamoeba histolytica hypothetical protein 0.0061 0.0242 0.0308
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Echinococcus multilocularis protein kinase shaggy 0.0106 0.0781 0.0743
Trypanosoma brucei cdc2-related kinase 1 0.0097 0.0667 0.0207
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0061 0.0237 0.0288
Echinococcus multilocularis serotonin transporter 0.0234 0.232 0.2308
Loa Loa (eye worm) hypothetical protein 0.0547 0.6077 0.9104
Echinococcus granulosus allatostatin A receptor 0.0061 0.0237 0.024
Schistosoma mansoni neuropeptide f receptor 76f 0.0061 0.0237 0.0288
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0106 0.0781 0.0791
Echinococcus multilocularis cyclin dependent kinase 5 0.0097 0.0667 0.0626
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0076 0.0419 0.0556
Echinococcus granulosus dro:myosuppressin receptor 0.0061 0.0237 0.024
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0058 0.0195 0.0218
Loa Loa (eye worm) hypothetical protein 0.0547 0.6077 0.9104
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0556
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0076 0.0419 0.0571
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0061 0.0237 0.0189
Plasmodium falciparum histone deacetylase, putative 0.0209 0.2014 0.4889
Loa Loa (eye worm) hypothetical protein 0.0462 0.5059 0.7566
Schistosoma mansoni hypothetical protein 0.0239 0.2374 0.3601
Schistosoma mansoni histamine h1 receptor 0.0061 0.0237 0.0288
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0237 0.0189
Trichomonas vaginalis cyclin H, putative 0.0061 0.0242 0.0388
Loa Loa (eye worm) ACC-1 protein 0.0076 0.0419 0.0556
Treponema pallidum sodium- and chloride- dependent transporter 0.0234 0.232 0.5
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0092 0.0614 0.0873
Brugia malayi histone deacetylase 11 0.01 0.0702 0.1009
Echinococcus multilocularis nAChR subunit 0.0076 0.0419 0.0375
Onchocerca volvulus 0.0239 0.2374 0.6989
Trichomonas vaginalis histone deacetylase, putative 0.0232 0.2292 0.3678
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0097 0.0667 0.0758
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0121 0.0958 0.137
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0232 0.2292 0.3678
Onchocerca volvulus 0.0061 0.0237 0.0559
Trypanosoma brucei histone deacetylase, putative 0.0209 0.2014 0.2578
Echinococcus granulosus neuropeptides capa receptor 0.0061 0.0237 0.024
Schistosoma mansoni biogenic amine receptor 0.0061 0.0237 0.0288
Loa Loa (eye worm) hypothetical protein 0.0092 0.0614 0.0851
Trichomonas vaginalis CMGC family protein kinase 0.0121 0.0958 0.1537
Schistosoma mansoni nAChR subunit 0.0076 0.0419 0.0571
Echinococcus multilocularis neuropeptide Y receptor 0.0061 0.0237 0.0189
Leishmania major protein kinase, putative 0.0363 0.3866 0.6071
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0958 0.1537
Schistosoma mansoni nAChR subunit 0.0076 0.0419 0.0571
Trypanosoma cruzi histone deacetylase 1, putative 0.0232 0.2292 0.3421
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.0121 0.0958 0.0922
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0217 0.0168
Echinococcus granulosus neuropeptide FF receptor 2 0.0061 0.0237 0.024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0237 0.0288
Brugia malayi Carboxylesterase family protein 0.0092 0.0614 0.0873
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0092 0.0614 0.0873
Echinococcus multilocularis dual specificity protein kinase clk2 0.0363 0.3866 0.3881
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0211 0.0213
Echinococcus granulosus histone deacetylase 8 0.01 0.0702 0.0711
Echinococcus granulosus cyclins 0.0062 0.0248 0.0251
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0076 0.0419 0.0571
Giardia lamblia Kinase, CMGC CDK 0.0097 0.0667 0.07
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Schistosoma mansoni neuropeptide receptor 0.0061 0.0237 0.0288
Brugia malayi Endochitinase 0.0169 0.153 0.2292
Echinococcus multilocularis cyclins 0.0062 0.0248 0.0201
Echinococcus granulosus nAChR subunit 0.0046 0.0051 0.0052
Echinococcus multilocularis casein kinase I alpha 0.0087 0.0549 0.0507
Schistosoma mansoni nAChR subunit 0.0076 0.0419 0.0571
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0189 0.0213
Onchocerca volvulus Histone deacetylase 10 homolog 0.01 0.0702 0.1959
Giardia lamblia Kinase, CAMK CAMKL 0.0121 0.0958 0.1186
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Brugia malayi Cyclin, N-terminal domain containing protein 0.011 0.0827 0.1202
Loa Loa (eye worm) hypothetical protein 0.0264 0.2675 0.3964
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0564 0.0795
Echinococcus multilocularis dual specificity 0.056 0.6231 0.6287
Schistosoma mansoni serine/threonine protein kinase 0.0456 0.4984 0.7648
Brugia malayi hypothetical protein 0.0119 0.093 0.1363
Echinococcus multilocularis histone deacetylase 1 0.0232 0.2292 0.2279
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0076 0.0419 0.0571
Loa Loa (eye worm) haspin protein kinase 0.0596 0.667 1
Schistosoma mansoni nAChR subunit 0.0076 0.0419 0.0571
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0061 0.0237 0.0288
Trichomonas vaginalis cyclins, putative 0.011 0.0827 0.1327
Brugia malayi hypothetical protein 0.0061 0.0237 0.0288
Brugia malayi Carboxylesterase family protein 0.0092 0.0614 0.0873
Echinococcus granulosus tachykinin peptides receptor 99D 0.0061 0.0237 0.024
Echinococcus granulosus cyclin dependent kinase 7 0.0088 0.0564 0.0571
Loa Loa (eye worm) histone deacetylase 0.0209 0.2014 0.2966
Trichomonas vaginalis cyclin D, putative 0.0062 0.0248 0.0399
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0062 0.0243 0.0628
Echinococcus multilocularis histone deacetylase 0.0209 0.2014 0.1997
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0061 0.0237 0.024
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0076 0.0419 0.0425
Schistosoma mansoni neuropeptide receptor 0.0061 0.0237 0.0288
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Entamoeba histolytica protein kinase domain containing protein 0.0456 0.4984 0.7982
Brugia malayi Dopamine receptor 0.0061 0.0237 0.0288
Echinococcus multilocularis serotonin receptor 0.0326 0.3423 0.343
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.0121 0.0958 0.0719
Echinococcus granulosus dual specificity 0.056 0.6231 0.6307
Entamoeba histolytica protein kinase domain containing protein 0.0106 0.0781 0.1181
Trypanosoma cruzi histone deacetylase, putative 0.0209 0.2014 0.2958
Trypanosoma brucei histone deacetylase 3 0.0209 0.2014 0.2578
Trypanosoma cruzi histone deacetylase, putative 0.0209 0.2014 0.2958
Loa Loa (eye worm) hypothetical protein 0.0234 0.232 0.3427
Trichomonas vaginalis CMGC family protein kinase 0.056 0.6231 1
Brugia malayi hypothetical protein 0.0061 0.0237 0.0288
Plasmodium vivax histone deacetylase, putative 0.0209 0.2014 0.521
Trichomonas vaginalis CK1 family protein kinase 0.0087 0.0549 0.0882
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0127 0.0114
Brugia malayi jmjC domain containing protein 0.0057 0.0189 0.0213
Echinococcus multilocularis sex peptide receptor 0.0061 0.0237 0.0189
Trichomonas vaginalis cyclins, putative 0.0062 0.0248 0.0399
Echinococcus multilocularis allatostatin A receptor 0.0061 0.0237 0.0189
Echinococcus multilocularis 0.0062 0.0243 0.0195
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Echinococcus multilocularis fmrfamide receptor 0.0061 0.0237 0.0189
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0061 0.0237 0.0281
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0217 0.0006
Onchocerca volvulus 0.0076 0.0419 0.1108
Onchocerca volvulus 0.0087 0.0549 0.1499
Echinococcus granulosus fmrfamide receptor 0.0061 0.0237 0.024
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0087 0.0549 0.0753
Echinococcus multilocularis acetylcholinesterase 0.0547 0.6077 0.6131
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0061 0.0237 0.024
Echinococcus multilocularis cyclins 0.0062 0.0248 0.0201
Echinococcus multilocularis G-protein coupled receptor, putative 0.0061 0.0237 0.0189
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0556
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0061 0.0237 0.024
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.056 0.6231 1
Echinococcus multilocularis orexin receptor type 2 0.0061 0.0237 0.0189
Echinococcus multilocularis somatostatin receptor 0.0061 0.0237 0.0189
Trypanosoma brucei histone deacetylase 4 0.0209 0.2014 0.2578
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0237 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0061 0.0237 0.024
Echinococcus granulosus g protein coupled receptor 0.0061 0.0237 0.024
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0189 0.014
Plasmodium vivax serine/threonine kinase-1, putative 0.0363 0.3866 1
Loa Loa (eye worm) hypothetical protein 0.0232 0.2292 0.3385
Loa Loa (eye worm) cuticular endochitinase 0.015 0.1311 0.1904
Brugia malayi Carboxylesterase family protein 0.0092 0.0614 0.0873
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.0121 0.0958 0.137
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0234 0.232 0.3517
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0088 0.0566 0.0573
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0195 0.0223
Schistosoma mansoni histone deacetylase 0.0232 0.2292 0.3474
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0322 0.3374 0.502
Giardia lamblia Kinase, CAMK CAMKL 0.0121 0.0958 0.1186
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0076 0.0419 0.0571
Giardia lamblia Histone deacetylase 0.0232 0.2292 0.3415
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0456 0.4984 0.7928
Schistosoma mansoni opsin-like receptor 0.0061 0.0237 0.0288
Loa Loa (eye worm) hypothetical protein 0.0349 0.3697 0.5507
Loa Loa (eye worm) hypothetical protein 0.0092 0.0614 0.0851
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0667 0.0955
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0061 0.0237 0.0288
Schistosoma mansoni hypothetical protein 0.0061 0.0237 0.0288
Brugia malayi neuropeptide F receptor 0.0061 0.0237 0.0288
Brugia malayi hypothetical protein 0.0061 0.0237 0.0288
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0556
Trypanosoma cruzi histone deacetylase 1, putative 0.0232 0.2292 0.3421
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0106 0.0781 0.1103
Onchocerca volvulus 0.0076 0.0419 0.1108
Onchocerca volvulus Putative endochitinase 0.015 0.1311 0.3793
Leishmania major serine/threonine kinase-like protein, putative 0.0121 0.0958 0.1241
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0958 0.1406
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0363 0.3866 0.5837
Schistosoma mansoni histone deacetylase 1 2 3 0.01 0.0702 0.1009
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0076 0.0419 0.0375
Schistosoma mansoni neuroligin 3 (S09 family) 0.0092 0.0614 0.0873
Onchocerca volvulus Putative endochitinase 0.015 0.1311 0.3793
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Loa Loa (eye worm) hypothetical protein 0.0109 0.0816 0.1155
Schistosoma mansoni biogenic amine receptor 0.0061 0.0237 0.0288
Onchocerca volvulus 0.0061 0.0237 0.0559
Trichomonas vaginalis CMGC family protein kinase 0.0121 0.0958 0.1537
Echinococcus granulosus alpha 1A adrenergic receptor 0.0061 0.0237 0.024
Trichomonas vaginalis CK1 family protein kinase 0.0087 0.0549 0.0882
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0062 0.0243 0.0195
Echinococcus granulosus neuropeptides capa receptor 0.0061 0.0237 0.024
Leishmania major protein kinase, putative 0.0363 0.3866 0.6071
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0062 0.0243 0.0033
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Schistosoma mansoni histone deacetylase 0.0232 0.2292 0.3474
Schistosoma mansoni lipoxygenase 0.0114 0.0877 0.1281
Leishmania major cyclin 0.011 0.0827 0.1023
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0061 0.0237 0.0288
Brugia malayi hypothetical protein 0.0158 0.1404 0.2098
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0556
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0061 0.0237 0.0288
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0061 0.0237 0.0189
Onchocerca volvulus 0.0073 0.038 0.0991
Loa Loa (eye worm) hypothetical protein 0.0076 0.0419 0.0556
Echinococcus granulosus dual specificity 0.056 0.6231 0.6307
Echinococcus granulosus cyclin dependent kinase 5 0.0097 0.0667 0.0675
Echinococcus granulosus histone deacetylase 6 0.0215 0.2086 0.2111
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0211 0.0162
Brugia malayi putative neuropeptide receptor 0.0061 0.0237 0.0288
Loa Loa (eye worm) hypothetical protein 0.0119 0.093 0.1328
Schistosoma mansoni serine/threonine protein kinase 0.056 0.6231 0.9582
Loa Loa (eye worm) carboxylesterase 0.0547 0.6077 0.9104
Brugia malayi endochitinase 0.0169 0.153 0.2292
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Brugia malayi ORL1-like opioid receptor 0.0061 0.0237 0.0288
Loa Loa (eye worm) acetylcholinesterase 1 0.0547 0.6077 0.9104
Echinococcus granulosus mitogen activated protein kinase 15 0.0121 0.0958 0.0969
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Onchocerca volvulus 0.0061 0.0237 0.0559
Echinococcus granulosus lysine specific histone demethylase 1A 0.0062 0.0243 0.0246
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.017 0.1544 0.1519
Loa Loa (eye worm) hypothetical protein 0.0061 0.0237 0.0281
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0456 0.4984 0.7805
Echinococcus multilocularis rhodopsin orphan GPCR 0.0061 0.0237 0.0189
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0958 0.1537
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0958 0.1537
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0863 0.9881 1
Giardia lamblia Kinase, CMGC CDK 0.0097 0.0667 0.07

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1001 nM Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat hippocampal membrane ChEMBL. 18603331
Ki (binding) = 14936 nM Displacement of [3H]ketanserin from 5HT2A receptor in rat cortical membrane ChEMBL. 18603331

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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