Detailed information for compound 1124421

Basic information

Technical information
  • TDR Targets ID: 1124421
  • Name: 4-amino-5-bromo-1-(oxan-2-yl)pyrimidin-2-one
  • MW: 274.114 | Formula: C9H12BrN3O2
  • H donors: 1 H acceptors: 1 LogP: 0.65 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc(=O)n(cc1Br)C1CCCCO1
  • InChi: 1S/C9H12BrN3O2/c10-6-5-13(9(14)12-8(6)11)7-3-1-2-4-15-7/h5,7H,1-4H2,(H2,11,12,14)
  • InChiKey: VPNCDRSZEJJPSI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-amino-5-bromo-1-tetrahydropyran-2-yl-pyrimidin-2-one
  • 4-amino-5-bromo-1-(2-tetrahydropyranyl)-2-pyrimidinone
  • 5580-94-9
  • 5-25-14-00444 (Beilstein Handbook Reference)
  • 5-Bromo-1-(tetrahydropyran-2-yl)cytosine
  • BRN 1577609
  • CYTOSINE, 5-BROMO-1-(TETRAHYDROPYRAN-2-YL)-
  • Cytosine, 5-bromo-1-(tetrahydro-2H-pyran-2-yl)- (8CI)
  • NSC 97839
  • NCIOpen2_006695
  • Cytosine, 5-bromo-1-(tetrahydro-2H-pyran-2-yl)-
  • NSC97839

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.1794
Loa Loa (eye worm) calpain 0.0184 0.2983 0.2983
Trypanosoma brucei cysteine peptidase C (CPC) 0.0192 0.3129 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0028 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1045 0.334
Plasmodium vivax vivapain-1 0.005 0.0455 0.1525
Echinococcus granulosus calpain 5 0.0184 0.2983 0.2983
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0081 0.1045 0.1045
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0053 0.0053
Brugia malayi calpain 7 0.0184 0.2983 0.2983
Loa Loa (eye worm) hypothetical protein 0.0081 0.1045 0.1045
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0028 0.0053 0.0168
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.1794
Giardia lamblia Encystation-specific protease 0.0028 0.0053 0.0168
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0558 1 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.005 0.0455 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.0081 0.1045 0.1045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0053 0.0168
Echinococcus multilocularis calpain 5 0.0184 0.2983 0.2983
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1045 0.334
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.1794
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0514 0.9176 0.9176
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0055 0.0561 0.1794
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0055 0.0561 0.0561
Onchocerca volvulus 0.0081 0.1045 0.1996
Loa Loa (eye worm) hypothetical protein 0.006 0.0643 0.0643
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0184 0.2983 0.9533
Onchocerca volvulus 0.006 0.0643 0.1227
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0081 0.1045 0.334
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1045 0.334
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.1794
Trypanosoma brucei cysteine peptidase, putative 0.0055 0.0561 0.1794
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1045 0.334
Trypanosoma brucei calpain-like protein, putative 0.0184 0.2983 0.9533
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0558 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1045 0.334
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0055 0.0561 0.1794
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0514 0.9176 0.9176
Plasmodium falciparum cysteine proteinase falcipain 3 0.0081 0.1045 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0092 0.0395
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.0561
Toxoplasma gondii cathepsin B 0.0192 0.3129 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0081 0.1045 0.334
Onchocerca volvulus 0.0081 0.1045 0.1996
Giardia lamblia Cathepsin L precursor 0.0028 0.0053 0.0168
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0028 0.0053 0.0168
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0028 0.0053 0.0176
Schistosoma mansoni calpain-2 (C02 family) 0.0055 0.0561 0.0561
Trypanosoma cruzi conserved protein 0.0055 0.0561 0.0561
Loa Loa (eye worm) fibroinase 0.0081 0.1045 0.1045
Leishmania major kinesin, putative 0.0129 0.1942 0.6207
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0489 0.87 0.87
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1045 0.334
Brugia malayi fibroinase precursor 0.0028 0.0053 0.0053
Giardia lamblia Cathepsin L-like protease 0.0028 0.0053 0.0168
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0028 0.0053 0.0168
Onchocerca volvulus Cathepsin L homolog 0.0081 0.1045 0.1996
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0192 0.3129 0.3129
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0028 0.0053 0.0053
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.005 0.0455 0.0455
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0081 0.1045 0.334
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0788 0.0788
Brugia malayi cathepsin L precursor 0.0028 0.0053 0.0053
Leishmania major hypothetical protein, unknown function 0.0055 0.0561 0.1794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0053 0.0168
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.1794
Echinococcus multilocularis calpain 7 (C02 family) 0.0184 0.2983 0.2983
Entamoeba histolytica calpain family cysteine protease, putative 0.0055 0.0561 0.289
Brugia malayi calpain D 0.0055 0.0561 0.0561
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1045 0.334
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0028 0.0053 0.0176
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0184 0.2983 0.2983
Echinococcus granulosus calpain A 0.0184 0.2983 0.2983
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0192 0.3129 1
Schistosoma mansoni cathepsin F (C01 family) 0.006 0.0643 0.0643
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0092 0.0092
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0053 0.0168
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0028 0.0053 0.0168
Onchocerca volvulus 0.0081 0.1045 0.1996
Trichomonas vaginalis calpain, putative 0.0055 0.0561 0.1794
Giardia lamblia Cathepsin L precursor 0.0028 0.0053 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1045 0.334
Echinococcus granulosus cathepsin b 0.0558 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0455 0.1454
Echinococcus granulosus cathepsin L 0.0028 0.0053 0.0053
Schistosoma mansoni cathepsin S (C01 family) 0.0028 0.0053 0.0053
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0788 0.0788
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0055 0.0561 0.0561
Echinococcus granulosus cathepsin L cysteine proteinase 0.0081 0.1045 0.1045
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0788 0.0788
Onchocerca volvulus 0.0081 0.1045 0.1996
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0028 0.0053 0.0053
Echinococcus granulosus cathepsin l cysteine peptidase 0.0081 0.1045 0.1045
Entamoeba histolytica cysteine protease, putative 0.005 0.0455 0.2343
Entamoeba histolytica cysteine protease, putative 0.0028 0.0053 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0028 0.0053 0.0168
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0081 0.1045 0.334
Plasmodium vivax unspecified product 0.005 0.0455 0.1525
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0055 0.0561 0.0561
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.1794
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0081 0.1045 0.1045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1045 0.334
Trypanosoma cruzi cysteine proteinase, putative 0.005 0.0455 0.0455
Leishmania major cathepsin L-like protease 0.0081 0.1045 0.334
Brugia malayi cathepsin Z-like cysteine proteinase 0.0028 0.0053 0.0053
Giardia lamblia Cysteine protease 0.0028 0.0053 0.0168
Brugia malayi Cathepsin L-like precursor 0.0081 0.1045 0.1045
Leishmania major cathepsin L-like protease 0.0081 0.1045 0.334
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0053 0.0168
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0455 0.2343
Entamoeba histolytica cysteine protease, putative 0.005 0.0455 0.2343
Leishmania major cathepsin L-like protease 0.0081 0.1045 0.334
Trypanosoma brucei Calpain-like protein 2 0.0055 0.0561 0.1794
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0053 0.0053
Plasmodium vivax unspecified product 0.0028 0.0053 0.0176
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0514 0.9176 0.9176
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0028 0.0053 0.0176
Brugia malayi Cathepsin L-like precursor 0.0081 0.1045 0.1045
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0028 0.0053 0.0176
Trypanosoma cruzi cysteine proteinase, putative 0.005 0.0455 0.0455
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0092 0.0294
Loa Loa (eye worm) RNA binding protein 0.0067 0.0788 0.0788
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1045 0.334
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0081 0.1045 1
Trypanosoma cruzi kinesin, putative 0.0129 0.1942 0.1942
Trypanosoma brucei kinesin, putative 0.0129 0.1942 0.6207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0643 0.2054
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0055 0.0561 0.1794
Loa Loa (eye worm) hypothetical protein 0.003 0.0092 0.0092
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.0561
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0788 0.0788
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0055 0.0561 0.0561
Giardia lamblia Cysteine protease 0.0028 0.0053 0.0168
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0028 0.0053 0.0271
Giardia lamblia Cathepsin B precursor 0.0028 0.0053 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0561 0.1794
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0053 0.0168
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0055 0.0561 0.1794
Trypanosoma brucei calpain, putative 0.0055 0.0561 0.1794
Leishmania major calpain family cysteine protease-like protein 0.0055 0.0561 0.1794
Giardia lamblia Cathepsin B precursor 0.0192 0.3129 1
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0092 0.0294
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0053 0.0168
Trypanosoma brucei calpain, putative 0.0055 0.0561 0.1794
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0788 0.0788
Trypanosoma brucei Calpain-like protein 1.2 0.0055 0.0561 0.1794
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0028 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0055 0.0561 0.0561
Trypanosoma brucei Calpain-like protein CALP1.3 0.0055 0.0561 0.1794
Entamoeba histolytica cysteine protease, putative 0.0028 0.0053 0.0271
Echinococcus multilocularis cathepsin L cysteine protease 0.0081 0.1045 0.1045
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0055 0.0561 0.0561
Trypanosoma cruzi cysteine peptidase, putative 0.0081 0.1045 0.1045
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0028 0.0053 0.0168
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0028 0.0053 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0053 0.0168
Loa Loa (eye worm) hypothetical protein 0.0028 0.0053 0.0053
Echinococcus granulosus cathepsin L 0.005 0.0455 0.0455
Trypanosoma cruzi kinesin, putative 0.0129 0.1942 0.1942
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0558 1 1
Trichomonas vaginalis calpain, putative 0.0055 0.0561 0.1794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1045 0.334
Trypanosoma brucei hypothetical protein 0.0055 0.0561 0.1794
Trypanosoma cruzi cysteine peptidase, putative 0.0081 0.1045 0.1045
Brugia malayi Cathepsin L-like precursor 0.0081 0.1045 0.1045
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.1794
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0055 0.0561 0.0561
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0055 0.0561 0.0561
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0053 0.0053
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0028 0.0053 0.0053
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0055 0.0561 0.0561
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0455 0.0455
Trypanosoma cruzi cysteine peptidase, putative 0.0081 0.1045 0.1045
Echinococcus multilocularis hypothetical protein 0.0184 0.2983 0.2983
Echinococcus granulosus cysteine protease 0.005 0.0455 0.0455
Trypanosoma cruzi cysteine protease, putative 0.005 0.0455 0.0455
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.1794
Echinococcus multilocularis calpain A 0.0514 0.918 0.918
Schistosoma mansoni calpain (C02 family) 0.0184 0.2983 0.2983
Giardia lamblia Hypothetical protein 0.0028 0.0053 0.0168
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0184 0.2983 0.2983
Echinococcus multilocularis cathepsin L 0.0028 0.0053 0.0053
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.005 0.0455 0.0455
Loa Loa (eye worm) cathepsin B 0.0192 0.3129 0.3129
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.1794
Echinococcus multilocularis cathepsin b 0.0558 1 1
Giardia lamblia Cysteine protease 0.0028 0.0053 0.0168
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0643 0.0643
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.0561
Echinococcus granulosus cathepsin b 0.0558 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0028 0.0053 0.0053
Loa Loa (eye worm) calpain D 0.0055 0.0561 0.0561
Entamoeba histolytica cysteine protease, putative 0.005 0.0455 0.2343
Giardia lamblia Hypothetical protein 0.0028 0.0053 0.0168
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.0561
Trypanosoma brucei Calpain-like protein 1.1 0.0055 0.0561 0.1794
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0192 0.3129 0.3129
Loa Loa (eye worm) hypothetical protein 0.0028 0.0053 0.0053
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.1794
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0455 0.2343
Loa Loa (eye worm) hypothetical protein 0.0433 0.7659 0.7659
Onchocerca volvulus Cathepsin F homolog 0.0081 0.1045 0.1996
Entamoeba histolytica cysteine protease, putative 0.005 0.0455 0.2343
Trypanosoma brucei calpain-like protein, putative 0.0184 0.2983 0.9533
Loa Loa (eye worm) hypothetical protein 0.0304 0.5237 0.5237
Echinococcus multilocularis cathepsin b 0.0558 1 1
Plasmodium vivax vivapain-2 0.0081 0.1045 0.3504
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0081 0.1045 0.334
Entamoeba histolytica cysteine protease, putative 0.005 0.0455 0.2343
Loa Loa (eye worm) hypothetical protein 0.0028 0.0053 0.0053
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0184 0.2983 0.2983
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0455 0.2343
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0028 0.0053 0.0168
Entamoeba histolytica cysteine proteinase 1, putative 0.005 0.0455 0.2343
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0028 0.0053 0.0053
Brugia malayi calpain family protein 1 0.0489 0.87 0.87
Trypanosoma brucei calpain-like protein, putative 0.0184 0.2983 0.9533
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0028 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1045 0.334
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0055 0.0561 0.1794
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0055 0.0561 0.0561
Echinococcus multilocularis calpain family protein 1, d 0.036 0.6278 0.6278
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0184 0.2983 0.2983
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0028 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0053 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1045 0.334
Loa Loa (eye worm) calpain family protein 1 0.036 0.6278 0.6278
Echinococcus granulosus tar DNA binding protein 0.0067 0.0788 0.0788
Toxoplasma gondii cathepsin CPC1 0.0028 0.0053 0.0168
Plasmodium vivax serine-repeat antigen (SERA) 0.0028 0.0053 0.0176
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.0561
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0788 0.0788
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.0561
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0055 0.0561 0.0561
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0055 0.0561 0.1794
Loa Loa (eye worm) hypothetical protein 0.0558 1 1
Giardia lamblia Cathepsin L-like protease 0.0028 0.0053 0.0168
Schistosoma mansoni calpain-7 (C02 family) 0.0184 0.2983 0.2983
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0028 0.0053 0.0176
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0184 0.2983 0.2983
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.1794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1045 0.334
Entamoeba histolytica cysteine protease, putative 0.005 0.0455 0.2343
Echinococcus granulosus cathepsin L cysteine protease 0.005 0.0455 0.0455
Brugia malayi Cathepsin L-like cysteine proteinase 0.006 0.0643 0.0643
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0028 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1045 0.334
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0028 0.0053 0.0271
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.1794
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0558 1 1
Leishmania major hypothetical protein, conserved 0.003 0.0092 0.0294
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.1794
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.1794
Giardia lamblia Cathepsin L precursor 0.0028 0.0053 0.0168
Entamoeba histolytica cysteine proteinase 2 0.005 0.0455 0.2343
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.1794
Leishmania major cathepsin L-like protease 0.0081 0.1045 0.334
Entamoeba histolytica cysteine protease, putative 0.005 0.0455 0.2343
Giardia lamblia Cathepsin L precursor 0.0028 0.0053 0.0168
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0028 0.0053 0.0053
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0028 0.0053 0.0176
Onchocerca volvulus 0.0081 0.1045 0.1996
Trypanosoma cruzi major cysteine proteinase, putative 0.0028 0.0053 0.0053
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.0561
Brugia malayi Cathepsin L-like precursor 0.0081 0.1045 0.1045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0455 0.1454
Schistosoma mansoni Mername-AA248 (C02 family) 0.0184 0.2983 0.2983
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0455 0.1454
Entamoeba histolytica cysteine protease, putative 0.005 0.0455 0.2343
Entamoeba histolytica cysteine protease, putative 0.005 0.0455 0.2343
Toxoplasma gondii hypothetical protein 0.0055 0.0561 0.1794
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0081 0.1045 0.334
Plasmodium falciparum calpain 0.0055 0.0561 0.5125
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0028 0.0053 0.0176
Loa Loa (eye worm) calpain 5 0.0129 0.1942 0.1942
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1045 0.334
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0028 0.0053 0.0168
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0028 0.0053 0.0053
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.1794
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1045 0.334
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0081 0.1045 0.334
Entamoeba histolytica cysteine protease, putative 0.005 0.0455 0.2343
Trypanosoma brucei antigen, putative 0.0184 0.2983 0.9533
Echinococcus granulosus cathepsin l1 0.0081 0.1045 0.1045
Entamoeba histolytica cysteine proteinase, putative 0.0081 0.1045 0.5382
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.005 0.0455 0.0455
Schistosoma mansoni calpain C (C02 family) 0.0184 0.2983 0.2983
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0788 0.0788
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1045 0.334
Giardia lamblia Cathepsin B precursor 0.0028 0.0053 0.0168
Brugia malayi Papain family cysteine protease containing protein 0.0081 0.1045 0.1045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1045 0.334
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0455 0.1454
Entamoeba histolytica cysteine protease, putative 0.0028 0.0053 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1045 0.334
Echinococcus granulosus calpain 7 C02 family 0.0184 0.2983 0.2983
Onchocerca volvulus 0.0081 0.1045 0.1996
Entamoeba histolytica cysteine protease, putative 0.0028 0.0053 0.0271
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0081 0.1045 0.334
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0192 0.3129 1
Plasmodium vivax calpain, putative 0.0184 0.2983 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1045 0.334
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0788 0.0788
Brugia malayi Cathepsin L-like precursor 0.0081 0.1045 0.1045
Schistosoma mansoni hypothetical protein 0.0055 0.0561 0.0561
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0028 0.0053 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0184 0.2983 0.9533
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.1794
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.1794
Entamoeba histolytica cysteine proteinase, putative 0.0081 0.1045 0.5382
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.0561
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0053 0.0168
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.005 0.0455 0.0455
Brugia malayi calpain 5 0.0129 0.1942 0.1942
Loa Loa (eye worm) cysteine protease 0.0081 0.1045 0.1045
Echinococcus multilocularis calpain 0.0184 0.2983 0.2983
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0092 0.0395
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0081 0.1045 0.1045
Brugia malayi cathepsin L-like precursor 0.006 0.0643 0.0643
Trypanosoma cruzi cruzipain precursor, putative 0.0081 0.1045 0.1045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1045 0.334
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0184 0.2983 0.9533
Loa Loa (eye worm) hypothetical protein 0.0489 0.87 0.87
Echinococcus multilocularis cathepsin L cysteine protease 0.0081 0.1045 0.1045
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0028 0.0053 0.0168
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0055 0.0561 0.1794
Entamoeba histolytica cysteine protease, putative 0.0028 0.0053 0.0271
Leishmania major cathepsin L-like protease 0.0081 0.1045 0.334
Brugia malayi cathepsin Z-like cysteine proteinase 0.0028 0.0053 0.0053
Plasmodium vivax vivapain-2 0.0081 0.1045 0.3504
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0184 0.2983 0.2983
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0514 0.9176 0.9176
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0081 0.1045 0.1045
Entamoeba histolytica cysteine protease, putative 0.0028 0.0053 0.0271
Trichomonas vaginalis hypothetical protein 0.0055 0.0561 0.1794
Loa Loa (eye worm) hypothetical protein 0.036 0.6278 0.6278
Entamoeba histolytica cysteine protease, putative 0.005 0.0455 0.2343
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0081 0.1045 0.334
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.006 0.0643 0.2054
Schistosoma mansoni calpain-7 (C02 family) 0.0184 0.2983 0.2983
Loa Loa (eye worm) hypothetical protein 0.0028 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0028 0.0053 0.0168
Leishmania major cathepsin L-like protease 0.0081 0.1045 0.334
Loa Loa (eye worm) hypothetical protein 0.006 0.0643 0.0643
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0092 0.0308
Echinococcus granulosus calpain A 0.0514 0.918 0.918
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0055 0.0561 0.1794
Echinococcus multilocularis cysteine protease 0.0081 0.1045 0.1045
Schistosoma mansoni cathepsin B (C01 family) 0.0028 0.0053 0.0053
Trichomonas vaginalis calpain, putative 0.0055 0.0561 0.1794
Entamoeba histolytica cysteine proteinase, putative 0.006 0.0643 0.331
Echinococcus granulosus cathepsin l1 0.006 0.0643 0.0643
Entamoeba histolytica protein kinase, putative 0.0129 0.1942 1
Onchocerca volvulus Cathepsin L homolog 0.0081 0.1045 0.1996
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0455 0.2343
Onchocerca volvulus 0.0028 0.0053 0.01
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0184 0.2983 0.9533
Giardia lamblia Cathepsin B precursor 0.0192 0.3129 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0028 0.0053 0.0168
Entamoeba histolytica cysteine protease, putative 0.005 0.0455 0.2343
Entamoeba histolytica cysteine protease, putative 0.0081 0.1045 0.5382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0053 0.0168
Giardia lamblia Cathepsin B precursor 0.0028 0.0053 0.0168
Trypanosoma cruzi major cysteine proteinase, putative 0.0028 0.0053 0.0053
Onchocerca volvulus Cathepsin L homolog 0.0028 0.0053 0.01
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0028 0.0053 0.0176
Toxoplasma gondii cathepsin CPC2 0.0028 0.0053 0.0168
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0081 0.1045 0.334
Giardia lamblia Cathepsin B precursor 0.0192 0.3129 1
Leishmania major cathepsin L-like protease 0.0081 0.1045 0.334
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0184 0.2983 0.2983
Leishmania major hypothetical protein, conserved 0.0055 0.0561 0.1794
Brugia malayi Cathepsin L-like precursor 0.006 0.0643 0.0643
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0561 0.1794
Trypanosoma cruzi cysteine peptidase, putative 0.0081 0.1045 0.1045
Toxoplasma gondii preprocathepsin c precursor, putative 0.0028 0.0053 0.0168
Giardia lamblia Cathepsin L precursor 0.0028 0.0053 0.0168
Onchocerca volvulus 0.0304 0.5237 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0558 1 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0028 0.0053 0.0176
Loa Loa (eye worm) ctsf protein 0.0081 0.1045 0.1045
Brugia malayi RNA binding protein 0.0067 0.0788 0.0788
Trypanosoma brucei calpain-like protein, putative 0.0184 0.2983 0.9533
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0053 0.0168
Echinococcus multilocularis cysteine protease 0.0081 0.1045 0.1045
Leishmania major cysteine peptidase A (CPA) 0.0081 0.1045 0.334
Brugia malayi Cathepsin L-like precursor 0.006 0.0643 0.0643
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1045 0.334
Loa Loa (eye worm) hypothetical protein 0.0028 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0055 0.0561 0.1794
Onchocerca volvulus 0.0081 0.1045 0.1996
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0184 0.2983 0.2983
Brugia malayi Cathepsin L-like precursor 0.0081 0.1045 0.1045
Loa Loa (eye worm) hypothetical protein 0.0028 0.0053 0.0053
Toxoplasma gondii cathepsin CPL 0.0081 0.1045 0.334
Brugia malayi calpain 5 0.0055 0.0561 0.0561
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0184 0.2983 0.9533
Plasmodium vivax serine-repeat antigen (SERA) 0.0028 0.0053 0.0176
Brugia malayi hypothetical protein 0.003 0.0092 0.0092
Echinococcus multilocularis cathepsin L 0.005 0.0455 0.0455
Entamoeba histolytica hypothetical protein 0.0028 0.0053 0.0271
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0092 0.0092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1045 0.334
Plasmodium vivax vivapain-3 0.005 0.0455 0.1525
Entamoeba histolytica calpain large subunit domain III containing protein 0.0129 0.1942 1
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0455 0.0455
Giardia lamblia Cathepsin B precursor 0.0028 0.0053 0.0168
Giardia lamblia Cathepsin B precursor 0.0028 0.0053 0.0168
Schistosoma mansoni cathepsin C 0.0028 0.0053 0.0053
Brugia malayi cathepsin L-like cysteine proteinase 0.0028 0.0053 0.0053
Giardia lamblia Cathepsin L precursor 0.0028 0.0053 0.0168
Loa Loa (eye worm) hypothetical protein 0.006 0.0643 0.0643
Schistosoma mansoni cathepsin F (C01 family) 0.0081 0.1045 0.1045
Brugia malayi TAR-binding protein 0.0067 0.0788 0.0788
Leishmania major cathepsin L-like protease 0.0081 0.1045 0.334
Entamoeba histolytica cysteine protease, putative 0.005 0.0455 0.2343
Loa Loa (eye worm) calpain family protein 1 0.0489 0.87 0.87
Leishmania major calpain protease-like protein 0.0055 0.0561 0.1794
Brugia malayi calpain family protein 1 0.0489 0.87 0.87
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0028 0.0053 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1045 0.334
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0184 0.2983 0.2983
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0788 0.0788
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0055 0.0561 0.1794
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.0455 0.0455
Echinococcus granulosus calpain 0.0184 0.2983 0.2983
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0184 0.2983 0.2983
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0081 0.1045 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0028 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0081 0.1045 0.334
Giardia lamblia Cysteine protease 0.0028 0.0053 0.0168

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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