Detailed information for compound 1182205

Basic information

Technical information
  • TDR Targets ID: 1182205
  • Name: N-[2-[[2-(cyclopentylamino)-2-oxo-1-pyridin-4 -ylethyl]-(3-fluorophenyl)amino]-2-oxoethyl]f uran-2-carboxamide
  • MW: 464.489 | Formula: C25H25FN4O4
  • H donors: 2 H acceptors: 4 LogP: 3.02 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(N(c1cccc(c1)F)C(=O)CNC(=O)c1ccco1)c1ccncc1)NC1CCCC1
  • InChi: 1S/C25H25FN4O4/c26-18-5-3-8-20(15-18)30(22(31)16-28-24(32)21-9-4-14-34-21)23(17-10-12-27-13-11-17)25(33)29-19-6-1-2-7-19/h3-5,8-15,19,23H,1-2,6-7,16H2,(H,28,32)(H,29,33)
  • InChiKey: CVBROBPQSYSSFS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[[2-(cyclopentylamino)-2-oxo-1-(4-pyridyl)ethyl]-(3-fluorophenyl)amino]-2-oxo-ethyl]furan-2-carboxamide
  • N-[2-[[2-(cyclopentylamino)-2-oxo-1-(4-pyridyl)ethyl]-(3-fluorophenyl)amino]-2-oxoethyl]-2-furancarboxamide
  • N-[2-[[2-(cyclopentylamino)-2-keto-1-(4-pyridyl)ethyl]-(3-fluorophenyl)amino]-2-keto-ethyl]-2-furamide
  • N-[2-[[2-(cyclopentylamino)-2-oxo-1-pyridin-4-yl-ethyl]-(3-fluorophenyl)amino]-2-oxo-ethyl]furan-2-carboxamide
  • ASN 05584523

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei Calpain-like protein 1.1 0.006 0.0119 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0145 0.0499
Leishmania major cysteine peptidase A (CPA) 0.0064 0.0145 0.0308
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.0661 0.0652
Entamoeba histolytica cysteine protease, putative 0.0053 0.0074 0.0564
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0201 0.1022 0.116
Schistosoma mansoni hypothetical protein 0.0048 0.0041 0.0047
Brugia malayi Cathepsin L-like precursor 0.0064 0.0145 0.0155
Trypanosoma brucei calpain-like protein, putative 0.0201 0.1022 0.3615
Giardia lamblia Hypothetical protein 0.0046 0.0026 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0026 0.006
Leishmania major cathepsin L-like protease 0.0064 0.0145 0.0308
Trypanosoma cruzi cysteine protease, putative 0.0053 0.0074 0.0072
Schistosoma mansoni calpain-7 (C02 family) 0.0201 0.1022 0.1172
Entamoeba histolytica cysteine proteinase 1, putative 0.0053 0.0074 0.0564
Schistosoma mansoni hypothetical protein 0.006 0.0119 0.0136
Entamoeba histolytica hypothetical protein 0.0115 0.0473 0.4156
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.0392 0.0449
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0026 0.003
Trypanosoma brucei Calpain-like protein 1.2 0.006 0.0119 0.0209
Echinococcus granulosus cathepsin b 0.1397 0.8718 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.0712 0.0806
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0046 0.0026 0.0019
Brugia malayi RNA binding protein 0.0065 0.015 0.016
Loa Loa (eye worm) hypothetical protein 0.0047 0.0034 0.0028
Loa Loa (eye worm) hypothetical protein 0.0109 0.0429 0.0481
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0026 0.003
Echinococcus granulosus neuropeptide receptor A26 0.0493 0.2904 0.3324
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0216 0.1122 1
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0057 0.0174
Trypanosoma cruzi major cysteine proteinase, putative 0.0046 0.0026 0.0017
Entamoeba histolytica cysteine protease, putative 0.0053 0.0074 0.0564
Schistosoma mansoni tar DNA-binding protein 0.0065 0.015 0.0172
Plasmodium vivax vivapain-3 0.0053 0.0074 0.0564
Plasmodium vivax serine-repeat antigen (SERA) 0.0046 0.0026 0.013
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0201 0.1022 0.116
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0063 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0034 0.0089
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0464 0.2714 0.3114
Trypanosoma cruzi calpain cysteine peptidase, putative 0.006 0.0119 0.0123
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0046 0.0026 0.013
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0046 0.0026 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0145 0.0499
Entamoeba histolytica cysteine proteinase, putative 0.0064 0.0145 0.1199
Loa Loa (eye worm) hypothetical protein 0.0053 0.0073 0.0072
Echinococcus granulosus calcyphosin protein 0.0044 0.0012 0.0002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0115 0.0473 0.0532
Trypanosoma brucei cysteine peptidase C (CPC) 0.0464 0.2714 1
Onchocerca volvulus Cathepsin L homolog 0.0064 0.0145 0.0719
Entamoeba histolytica hypothetical protein 0.0115 0.0473 0.4156
Echinococcus multilocularis cathepsin b 0.1397 0.8718 0.8717
Brugia malayi cathepsin L-like cysteine proteinase 0.0046 0.0026 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0145 0.0499
Echinococcus multilocularis fk506 binding protein 0.0216 0.1122 0.1113
Onchocerca volvulus 0.0064 0.0145 0.0719
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0272 0.0968
Echinococcus multilocularis programmed cell death protein 6 0.0044 0.0012 0.0002
Echinococcus granulosus tar DNA binding protein 0.0065 0.015 0.016
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0694 0.4192 1
Echinococcus multilocularis hypothetical protein 0.0201 0.1022 0.1013
Onchocerca volvulus Cathepsin L homolog 0.0046 0.0026 0.0078
Entamoeba histolytica cysteine protease, putative 0.0053 0.0074 0.0564
Trichomonas vaginalis centrin, putative 0.0044 0.0012 0.0007
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0046 0.0026 0.013
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0063 0.0053
Schistosoma mansoni cathepsin S (C01 family) 0.0046 0.0026 0.003
Loa Loa (eye worm) hypothetical protein 0.0109 0.0429 0.0481
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0216 0.1122 0.1277
Plasmodium vivax vivapain-1 0.0053 0.0074 0.0564
Trichomonas vaginalis caltractin, putative 0.0044 0.0012 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0046 0.0026 0.006
Trypanosoma cruzi kinesin, putative 0.014 0.0634 0.0714
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0026 0.006
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0429 0.1549
Leishmania major peptidylprolyl isomerase-like protein 0.0216 0.1122 0.3992
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0464 0.2714 0.3104
Schistosoma mansoni calpain-2 (C02 family) 0.006 0.0119 0.0136
Onchocerca volvulus 0.0064 0.0145 0.0719
Schistosoma mansoni myosin regulatory light chain 0.0044 0.0012 0.0014
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0532 0.3153 0.3617
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.006 0.0119 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0034 0.0089
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0074 0.0564
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0026 0.006
Echinococcus granulosus calpain A 0.0201 0.1022 0.1162
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0063 0.0197
Echinococcus multilocularis neuropeptide s receptor 0.0493 0.2904 0.2897
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.006 0.0119 0.0123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0145 0.0499
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0123
Loa Loa (eye worm) hypothetical protein 0.0057 0.0097 0.01
Trypanosoma brucei caltractin, putative 0.0078 0.023 0.063
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0063 0.0059
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1397 0.8718 1
Trypanosoma brucei calpain, putative 0.006 0.0119 0.0209
Echinococcus multilocularis chromobox protein 1 0.0084 0.0272 0.0262
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1397 0.8718 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0046 0.0026 0.0019
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0029 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0064 0.0145 0.0499
Plasmodium falciparum serine repeat antigen 6 0.0046 0.0026 0.013
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0026 0.003
Toxoplasma gondii cathepsin B 0.0464 0.2714 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.006 0.0119 0.0123
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0216 0.1122 0.1277
Trichomonas vaginalis calpain, putative 0.006 0.0119 0.0402
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0029 0.0022
Brugia malayi cathepsin B-like cysteine proteinase 0.1397 0.8718 1
Onchocerca volvulus 0.0109 0.0429 0.2255
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0145 0.0499
Echinococcus multilocularis cathepsin L 0.0046 0.0026 0.0016
Loa Loa (eye worm) hypothetical protein 0.0057 0.0097 0.01
Brugia malayi Cathepsin L-like precursor 0.0057 0.0097 0.01
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0074 0.0564
Echinococcus granulosus cathepsin l1 0.0064 0.0145 0.0155
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0064 0.0145 0.0135
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1397 0.8718 1
Entamoeba histolytica hypothetical protein 0.0046 0.0026 0.013
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0216 0.1122 0.4107
Giardia lamblia Cathepsin L precursor 0.0046 0.0026 0.0053
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0064 0.0145 0.1199
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0209
Onchocerca volvulus 0.0057 0.0097 0.0459
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0046 0.0026 0.0053
Loa Loa (eye worm) hypothetical protein 0.0044 0.0012 0.0002
Brugia malayi Probable myosin regulatory light chain 0.0044 0.0012 0.0002
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0063 0.019
Toxoplasma gondii ABC1 family protein 0.0109 0.0429 0.1543
Echinococcus multilocularis cathepsin L cysteine protease 0.0064 0.0145 0.0135
Entamoeba histolytica protein kinase, putative 0.0141 0.0637 0.5628
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.006 0.0119 0.0395
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0064 0.0145 0.0155
Giardia lamblia Cathepsin L precursor 0.0046 0.0026 0.0053
Echinococcus granulosus cathepsin l cysteine peptidase 0.0064 0.0145 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0046 0.0026 0.006
Schistosoma mansoni tar DNA-binding protein 0.0065 0.015 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0026 0.006
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0064 0.0145 0.0155
Trypanosoma brucei centrin-3 0.0078 0.023 0.063
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0074 0.0564
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.006 0.0119 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0026 0.006
Trichomonas vaginalis hypothetical protein 0.006 0.0119 0.0402
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.006 0.0119 0.0402
Echinococcus granulosus Myosin regulatory light chain 0.0044 0.0012 0.0002
Trypanosoma cruzi centrin-3 0.0078 0.023 0.0251
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0029 0.0034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0145 0.0499
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.0382 0.0372
Schistosoma mansoni chromobox protein 0.0084 0.0272 0.0312
Leishmania major fk506-binding protein 1-like protein 0.0216 0.1122 0.3992
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0029 0.0034
Schistosoma mansoni hypothetical protein 0.0104 0.0401 0.046
Schistosoma mansoni transcription factor LCR-F1 0.0115 0.0473 0.0543
Brugia malayi Cathepsin L-like precursor 0.0064 0.0145 0.0155
Schistosoma mansoni tar DNA-binding protein 0.0065 0.015 0.0172
Toxoplasma gondii hypothetical protein 0.006 0.0119 0.0395
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0123
Entamoeba histolytica hypothetical protein 0.0115 0.0473 0.4156
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0216 0.1122 0.3992
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0026 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0429 0.0479
Schistosoma mansoni calpain C (C02 family) 0.0201 0.1022 0.1172
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0046 0.0026 0.013
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0209
Giardia lamblia Cathepsin L precursor 0.0046 0.0026 0.0053
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0216 0.1122 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0046 0.0026 0.013
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0046 0.0026 0.0053
Entamoeba histolytica cysteine protease, putative 0.0053 0.0074 0.0564
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0201 0.1022 0.3615
Entamoeba histolytica cysteine protease, putative 0.0053 0.0074 0.0564
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0145 0.0499
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0026 0.006
Echinococcus multilocularis cysteine protease 0.0064 0.0145 0.0135
Loa Loa (eye worm) FKBP5 protein 0.0216 0.1122 0.1277
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.006 0.0119 0.0402
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0026 0.006
Loa Loa (eye worm) hypothetical protein 0.0153 0.0712 0.0806
Schistosoma mansoni calmodulin-related 0.0044 0.0012 0.0014
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.0382 0.0427
Echinococcus granulosus calpain 7 C02 family 0.0201 0.1022 0.1162
Echinococcus granulosus neuropeptide s receptor 0.0493 0.2904 0.3324
Loa Loa (eye worm) calpain 0.0201 0.1022 0.1162
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0209
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0429 0.0492
Entamoeba histolytica cysteine protease, putative 0.0053 0.0074 0.0564
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0216 0.1122 0.3992
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0201 0.1022 0.3615
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.0044 0.0012 0.0007
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0145 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0046 0.0026 0.006
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0209
Brugia malayi Neuronal calcium sensor family protein 1 0.0044 0.0012 0.0002
Trypanosoma brucei calpain-like protein, putative 0.0201 0.1022 0.3615
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0201 0.1022 0.3615
Plasmodium falciparum cysteine proteinase falcipain 3 0.0064 0.0145 0.1199
Loa Loa (eye worm) calpain family protein 1 0.0392 0.225 0.2572
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0201 0.1022 0.116
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0064 0.0145 0.0499
Brugia malayi cathepsin F-like cysteine proteinase 0.0046 0.0026 0.0019
Plasmodium falciparum serine repeat antigen 7 0.0046 0.0026 0.013
Brugia malayi RasGEF domain containing protein 0.0044 0.0012 0.0002
Plasmodium vivax unspecified product 0.0053 0.0074 0.0564
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0145 0.0499
Plasmodium vivax calpain, putative 0.0201 0.1022 0.9098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0145 0.0308
Plasmodium vivax serine-repeat antigen (SERA) 0.0046 0.0026 0.013
Schistosoma mansoni immunophilin 0.0216 0.1122 0.1287
Onchocerca volvulus 0.0046 0.0026 0.0078
Echinococcus granulosus GPCR family 2 0.0048 0.0041 0.0036
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0057 0.0174
Onchocerca volvulus 0.0147 0.0676 0.3588
Schistosoma mansoni tar DNA-binding protein 0.0065 0.015 0.0172
Trichomonas vaginalis calpain, putative 0.006 0.0119 0.0402
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0119 0.0402
Giardia lamblia Cathepsin B precursor 0.0046 0.0026 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0209
Trypanosoma cruzi kinesin, putative 0.014 0.0634 0.0714
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0209
Onchocerca volvulus Cathepsin F homolog 0.0064 0.0145 0.0719
Loa Loa (eye worm) cysteine protease 0.0064 0.0145 0.0155
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1397 0.8718 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0063 0.0059
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0209
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0063 0.0059
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0429 0.1549
Echinococcus granulosus chromobox protein 1 0.0084 0.0272 0.0301
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0145 0.0153
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0429 0.0492
Plasmodium falciparum cysteine proteinase falcipain 1 0.0053 0.0074 0.0564
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0041 0.0031
Echinococcus granulosus Calcium binding protein 0.0044 0.0012 0.0002
Giardia lamblia Cysteine protease 0.0046 0.0026 0.0053
Loa Loa (eye worm) myosin regulatory light chain 1 0.0044 0.0012 0.0002
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.0382 0.3333
Loa Loa (eye worm) fibroinase 0.0064 0.0145 0.0155
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0046 0.0026 0.003
Echinococcus granulosus cathepsin L cysteine protease 0.0053 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0057 0.0097 0.01
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0074 0.0564
Schistosoma mansoni calpain-7 (C02 family) 0.0201 0.1022 0.1172
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0019
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0123
Loa Loa (eye worm) hypothetical protein 0.0109 0.0429 0.0481
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0216 0.1122 0.4111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0145 0.0308
Loa Loa (eye worm) hypothetical protein 0.0101 0.0382 0.0427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0145 0.0499
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0429 0.0479
Schistosoma mansoni hypothetical protein 0.0048 0.0041 0.0047
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0209
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0566 0.3371 0.3867
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0566 0.3371 0.3867
Entamoeba histolytica hypothetical protein 0.0115 0.0473 0.4156
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0041 0.0036
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0201 0.1022 0.116
Echinococcus multilocularis chromobox protein 1 0.0084 0.0272 0.0262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0026 0.006
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0209
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0123
Trichomonas vaginalis calpain, putative 0.006 0.0119 0.0402
Brugia malayi Cathepsin L-like precursor 0.0064 0.0145 0.0155
Giardia lamblia Cathepsin B precursor 0.0046 0.0026 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0145 0.0308
Trypanosoma brucei Calpain-like protein CALP1.3 0.006 0.0119 0.0209
Plasmodium falciparum calpain 0.006 0.0119 0.0963
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0145 0.0499
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0216 0.1122 0.1277
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0201 0.1022 0.3615
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0201 0.1022 0.116
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.0026 0.0019
Loa Loa (eye worm) hypothetical protein 0.0048 0.0041 0.0036
Entamoeba histolytica cysteine protease, putative 0.0053 0.0074 0.0564
Schistosoma mansoni immunophilin 0.0216 0.1122 0.1287
Echinococcus granulosus expressed conserved protein 0.0095 0.0342 0.0381
Schistosoma mansoni hypothetical protein 0.0522 0.3087 0.3541
Toxoplasma gondii cathepsin CPC2 0.0046 0.0026 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0145 0.0499
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0063 0.0061
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0046 0.0026 0.003
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0216 0.1122 0.1277
Loa Loa (eye worm) calpain 5 0.014 0.0634 0.0716
Echinococcus multilocularis neuropeptide receptor A26 0.0493 0.2904 0.2897
Brugia malayi Cathepsin L-like cysteine proteinase 0.0057 0.0097 0.01
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0019
Loa Loa (eye worm) calpain D 0.006 0.0119 0.0125
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.0429 0.0419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0145 0.0308
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0041 0.0036
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0216 0.1122 0.1277
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0063 0.0053
Echinococcus granulosus programmed cell death protein 0.0078 0.023 0.0253
Trypanosoma brucei Calpain-like protein 2 0.006 0.0119 0.0209
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0272 0.0301
Loa Loa (eye worm) hypothetical protein 0.0109 0.0429 0.0481
Giardia lamblia Cathepsin B precursor 0.0046 0.0026 0.0053
Brugia malayi Cathepsin L-like precursor 0.0057 0.0097 0.01
Plasmodium falciparum serine repeat antigen 4 0.0046 0.0026 0.013
Echinococcus multilocularis protein dispatched 1 0.005 0.005 0.004
Echinococcus granulosus programmed cell death protein 6 0.0044 0.0012 0.0002
Trypanosoma brucei antigen, putative 0.0201 0.1022 0.3615
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.0429 0.0481
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0029 0.0019
Schistosoma mansoni cathepsin F (C01 family) 0.0057 0.0097 0.0111
Giardia lamblia Cathepsin B precursor 0.0464 0.2714 1
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0566 0.3371 0.3365
Giardia lamblia Cathepsin L precursor 0.0046 0.0026 0.0053
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.0661 0.0748
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0046 0.0026 0.003
Brugia malayi cathepsin L-like precursor 0.0057 0.0097 0.01
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0186 0.093 0.0921
Entamoeba histolytica cysteine protease, putative 0.0046 0.0026 0.013
Leishmania major hypothetical protein, conserved 0.006 0.0119 0.0209
Echinococcus granulosus cysteine protease 0.0053 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0048 0.0041 0.0047
Echinococcus granulosus cathepsin l1 0.0057 0.0097 0.01
Brugia malayi hypothetical protein 0.0115 0.0473 0.0532
Entamoeba histolytica cysteine protease, putative 0.0046 0.0026 0.013
Onchocerca volvulus 0.0109 0.0429 0.2255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0026 0.006
Onchocerca volvulus Cathepsin L homolog 0.0064 0.0145 0.0719
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0063 0.0197
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0145 0.0499
Trypanosoma cruzi major cysteine proteinase, putative 0.0046 0.0026 0.0017
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0186 0.093 0.1057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0145 0.0308
Trypanosoma brucei hypothetical protein 0.006 0.0119 0.0209
Entamoeba histolytica cysteine protease, putative 0.0046 0.0026 0.013
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0429 0.1549
Entamoeba histolytica cysteine protease, putative 0.0064 0.0145 0.1199
Schistosoma mansoni Mername-AA248 (C02 family) 0.0201 0.1022 0.1172
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0041 0.0036
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0209
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0046 0.0026 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0145 0.0499
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.006 0.0119 0.0123
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0123
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0209
Trypanosoma cruzi conserved protein 0.006 0.0119 0.0123
Echinococcus multilocularis programmed cell death protein 0.0078 0.023 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0026 0.006
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0216 0.1122 1
Mycobacterium leprae conserved hypothetical protein 0.0109 0.0429 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0145 0.0499
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0216 0.1122 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0145 0.0499
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0063 0.0073
Loa Loa (eye worm) hypothetical protein 0.0064 0.0145 0.0155
Leishmania major hypothetical protein, conserved 0.0109 0.0429 0.1379
Entamoeba histolytica cysteine proteinase, putative 0.0057 0.0097 0.0766
Plasmodium vivax vivapain-2 0.0064 0.0145 0.1199
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0046 0.0026 0.013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0041 0.0036
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.006 0.0119 0.0209
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0429 0.3758
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0053 0.0074 0.0072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0074 0.0042
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0046 0.0026 0.013
Loa Loa (eye worm) calpain family protein 1 0.0532 0.3153 0.3609
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0201 0.1022 0.116
Echinococcus multilocularis calpain 7 (C02 family) 0.0201 0.1022 0.1013
Trichomonas vaginalis esterase, putative 0.0109 0.0429 0.1549
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0041 0.0031
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0046 0.0026 0.013
Brugia malayi MAP kinase sur-1 0.0052 0.0063 0.0061
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.006 0.0119 0.0402
Giardia lamblia Cathepsin L-like protease 0.0046 0.0026 0.0053
Loa Loa (eye worm) hypothetical protein 0.006 0.0119 0.0125
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0019
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0046 0.0026 0.013
Echinococcus multilocularis calpain 5 0.0201 0.1022 0.1013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.0712 0.0806
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0209
Echinococcus granulosus calpain A 0.0566 0.3371 0.386
Trichomonas vaginalis calcium binding protein, putative 0.0078 0.023 0.0814
Trichomonas vaginalis centrin, putative 0.0044 0.0012 0.0007
Mycobacterium leprae Probable lipase LipE 0.0109 0.0429 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0026 0.003
Loa Loa (eye worm) hypothetical protein 0.0109 0.0429 0.0481
Echinococcus granulosus calpain 0.0201 0.1022 0.1162
Echinococcus multilocularis expressed conserved protein 0.0095 0.0342 0.0333
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0216 0.1122 0.4107
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0046 0.0026 0.013
Entamoeba histolytica cysteine protease, putative 0.0046 0.0026 0.013
Brugia malayi hypothetical protein 0.0147 0.0676 0.0765
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0145 0.0499
Schistosoma mansoni cathepsin B (C01 family) 0.0046 0.0026 0.003
Echinococcus granulosus cathepsin L 0.0046 0.0026 0.0019
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0063 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0145 0.0499
Plasmodium falciparum serine repeat antigen 3 0.0046 0.0026 0.013
Echinococcus multilocularis calpain family protein 1, d 0.0392 0.225 0.2242
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0201 0.1022 0.116
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0145 0.0153
Loa Loa (eye worm) hypothetical protein 0.1397 0.8718 1
Entamoeba histolytica cysteine protease, putative 0.0053 0.0074 0.0564
Giardia lamblia Cathepsin B precursor 0.0046 0.0026 0.0053
Schistosoma mansoni tar DNA-binding protein 0.0065 0.015 0.0172
Trypanosoma cruzi cysteine proteinase, putative 0.0053 0.0074 0.0072
Echinococcus multilocularis calcyphosin protein 0.0044 0.0012 0.0002
Echinococcus multilocularis Myosin regulatory light chain 0.0044 0.0012 0.0002
Brugia malayi Cathepsin L-like precursor 0.0064 0.0145 0.0155
Loa Loa (eye worm) hypothetical protein 0.0331 0.1862 0.2127
Onchocerca volvulus 0.0064 0.0145 0.0719
Entamoeba histolytica cysteine protease, putative 0.0053 0.0074 0.0564
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0145 0.0499
Echinococcus multilocularis calpain 0.0201 0.1022 0.1013
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.006 0.0119 0.0123
Echinococcus multilocularis GPCR, family 2 0.0048 0.0041 0.0031
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0464 0.2714 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0029 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0145 0.0308
Echinococcus granulosus cathepsin L 0.0053 0.0074 0.0074
Brugia malayi fibroinase precursor 0.0046 0.0026 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0145 0.0308
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0029 0.0022
Plasmodium falciparum serine repeat antigen 5 0.0046 0.0026 0.013
Loa Loa (eye worm) hypothetical protein 0.0392 0.225 0.2572
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.006 0.0119 0.0123
Schistosoma mansoni cathepsin F (C01 family) 0.0064 0.0145 0.0166
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0057 0.0245
Schistosoma mansoni calpain (C02 family) 0.0201 0.1022 0.1172
Echinococcus granulosus cathepsin b 0.1397 0.8718 1
Echinococcus granulosus geminin 0.0522 0.3087 0.3534
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0216 0.1122 0.1275
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0115 0.0473 0.0464
Plasmodium vivax vivapain-2 0.0064 0.0145 0.1199
Brugia malayi calpain family protein 1 0.0532 0.3153 0.3609
Leishmania major cathepsin L-like protease 0.0064 0.0145 0.0308
Giardia lamblia Cathepsin L-like protease 0.0046 0.0026 0.0053
Schistosoma mansoni cathepsin C 0.0046 0.0026 0.003
Schistosoma mansoni cathepsin F (C01 family) 0.0064 0.0145 0.0166
Plasmodium falciparum serine repeat antigen 9 0.0046 0.0026 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0026 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0145 0.0499
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0145 0.0153
Giardia lamblia Hypothetical protein 0.0046 0.0026 0.0053
Loa Loa (eye worm) RNA binding protein 0.0065 0.015 0.016
Trichomonas vaginalis kakapo, putative 0.0044 0.0012 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0029 0.0034
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0046 0.0026 0.013
Brugia malayi Cathepsin L-like precursor 0.0064 0.0145 0.0155
Trichomonas vaginalis fk506-binding protein, putative 0.0216 0.1122 0.4111
Onchocerca volvulus 0.0064 0.0145 0.0719
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0145 0.0308
Brugia malayi Papain family cysteine protease containing protein 0.0064 0.0145 0.0155
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0216 0.1122 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0145 0.0308
Trichomonas vaginalis caltractin, putative 0.0044 0.0012 0.0007
Giardia lamblia Cysteine protease 0.0046 0.0026 0.0053
Plasmodium falciparum serine repeat antigen 8 0.0046 0.0026 0.013
Echinococcus granulosus cathepsin L cysteine proteinase 0.0064 0.0145 0.0155
Entamoeba histolytica cysteine proteinase, putative 0.0064 0.0145 0.1199
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0201 0.1022 0.116
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0429 0.1549
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.0712 0.0806
Giardia lamblia Cysteine protease 0.0046 0.0026 0.0053
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.015 0.016
Toxoplasma gondii cathepsin CPC1 0.0046 0.0026 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0074 0.0238
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.006 0.0119 0.0123
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0046 0.0026 0.0019
Schistosoma mansoni myosin light chain 0.0044 0.0012 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0145 0.0499
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0123
Plasmodium falciparum serine repeat antigen 1 0.0046 0.0026 0.013
Schistosoma mansoni myosin regulatory light chain 0.0044 0.0012 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0063 0.0197
Entamoeba histolytica cysteine proteinase 2 0.0053 0.0074 0.0564
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0401 0.0449
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0053 0.0074 0.0085
Loa Loa (eye worm) hypothetical protein 0.0472 0.2765 0.3164
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0046 0.0026 0.0053
Entamoeba histolytica calpain family cysteine protease, putative 0.006 0.0119 0.0963
Schistosoma mansoni patched 1 0.0043 0.001 0.0012
Brugia malayi cathepsin L precursor 0.0046 0.0026 0.0019
Loa Loa (eye worm) TAR-binding protein 0.0065 0.015 0.016
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0063 0.0061
Echinococcus multilocularis tar DNA binding protein 0.0065 0.015 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0026 0.006
Loa Loa (eye worm) ctsf protein 0.0064 0.0145 0.0155
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0019
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0046 0.0026 0.013
Trichomonas vaginalis calcium binding protein, putative 0.0044 0.0012 0.0007
Leishmania major calpain protease-like protein 0.006 0.0119 0.0209
Brugia malayi calpain 7 0.0201 0.1022 0.1162
Leishmania major calpain family cysteine protease-like protein 0.006 0.0119 0.0209
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0429 0.1549
Giardia lamblia Cathepsin B precursor 0.0046 0.0026 0.0053
Entamoeba histolytica cysteine protease, putative 0.0046 0.0026 0.013
Schistosoma mansoni immunophilin 0.0186 0.093 0.1067
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.006 0.0119 0.0123
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0074 0.0072
Echinococcus multilocularis calpain A 0.0566 0.3371 0.3365
Loa Loa (eye worm) hypothetical protein 0.0532 0.3153 0.3609
Brugia malayi Heterochromatin protein 1 0.0084 0.0272 0.0301
Brugia malayi calpain 5 0.014 0.0634 0.0716
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0034 0.012
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.0429 0.0481
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0216 0.1122 0.1287
Leishmania major cathepsin L-like protease 0.0064 0.0145 0.0308
Echinococcus multilocularis cathepsin L 0.0053 0.0074 0.0064
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0064 0.0145 0.0135
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0026 0.006
Brugia malayi cathepsin Z-like cysteine proteinase 0.0046 0.0026 0.0019
Brugia malayi Myosin regulatory light chain 1 0.0044 0.0012 0.0002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0145 0.0499
Giardia lamblia Cysteine protease 0.0046 0.0026 0.0053
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.0026 0.0019
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0216 0.1122 0.1275
Trypanosoma brucei calpain, putative 0.006 0.0119 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0046 0.0026 0.006
Loa Loa (eye worm) beta-lactamase 0.0109 0.0429 0.0481
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.0026 0.0019
Echinococcus granulosus calpain 5 0.0201 0.1022 0.1162
Brugia malayi beta-lactamase family protein 0.0109 0.0429 0.0481
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0216 0.1122 1
Entamoeba histolytica cysteine protease, putative 0.0053 0.0074 0.0564
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0201 0.1022 0.116
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0063 0.0197
Giardia lamblia Encystation-specific protease 0.0046 0.0026 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0145 0.0308
Brugia malayi beta-lactamase 0.0109 0.0429 0.0481
Echinococcus multilocularis Calcium binding protein 0.0044 0.0012 0.0002
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.006 0.0119 0.0402
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.006 0.0119 0.0402
Loa Loa (eye worm) hypothetical protein 0.0109 0.0429 0.0481
Plasmodium falciparum serine repeat antigen 2 0.0046 0.0026 0.013
Trypanosoma brucei calpain-like protein, putative 0.0201 0.1022 0.3615
Echinococcus multilocularis cathepsin L cysteine protease 0.0064 0.0145 0.0135
Leishmania major cathepsin L-like protease 0.0064 0.0145 0.0308
Leishmania major cathepsin L-like protease 0.0064 0.0145 0.0308
Toxoplasma gondii cathepsin CPL 0.0064 0.0145 0.0493
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0201 0.1022 0.116
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0053 0.0074 0.0085
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0046 0.0026 0.003
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0145 0.0153
Onchocerca volvulus 0.0064 0.0145 0.0719
Leishmania major cathepsin L-like protease 0.0064 0.0145 0.0308
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0209
Onchocerca volvulus 0.0064 0.0145 0.0719
Schistosoma mansoni hypothetical protein 0.0048 0.0041 0.0047
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.006 0.0119 0.0402
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0064 0.0145 0.1199
Onchocerca volvulus 0.0064 0.0145 0.0719
Onchocerca volvulus 0.0331 0.1862 1
Trichomonas vaginalis immunophilin, putative 0.0216 0.1122 0.4111
Echinococcus multilocularis cathepsin b 0.1397 0.8718 0.8717
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0053 0.0074 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0145 0.0499
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0145 0.0499
Brugia malayi TAR-binding protein 0.0065 0.015 0.016
Loa Loa (eye worm) hypothetical protein 0.0044 0.0012 0.0002
Entamoeba histolytica cysteine protease, putative 0.0053 0.0074 0.0564
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.0382 0.0427
Schistosoma mansoni hypothetical protein 0.0522 0.3087 0.3541
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0026 0.006
Brugia malayi cathepsin Z-like cysteine proteinase 0.0046 0.0026 0.0019
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.006 0.0119 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0464 0.2714 1
Brugia malayi calpain family protein 1 0.0532 0.3153 0.3609
Giardia lamblia Cathepsin L precursor 0.0046 0.0026 0.0053
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0074 0.0074
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.006 0.0119 0.0209
Giardia lamblia Cathepsin B precursor 0.0464 0.2714 1
Schistosoma mansoni hypothetical protein 0.0115 0.0473 0.0543
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0046 0.0026 0.013
Loa Loa (eye worm) cathepsin B 0.0464 0.2714 0.3106
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.015 0.016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0145 0.0308
Loa Loa (eye worm) hypothetical protein 0.0104 0.0401 0.0449
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0074 0.0074
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0097 0.0098
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0209
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0216 0.1122 0.1113
Toxoplasma gondii preprocathepsin c precursor, putative 0.0046 0.0026 0.0053
Brugia malayi Cathepsin L-like precursor 0.0064 0.0145 0.0155
Plasmodium vivax unspecified product 0.0046 0.0026 0.013
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0429 0.1379
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0209
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0063 0.0061
Brugia malayi chromobox protein homolog 3 0.0047 0.0034 0.0028
Entamoeba histolytica cysteine protease, putative 0.0053 0.0074 0.0564
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0209
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0046 0.0026 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0012 0.0007
Trichomonas vaginalis calmodulin, putative 0.0078 0.023 0.0814
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0216 0.1122 0.1275
Loa Loa (eye worm) hypothetical protein 0.0147 0.0676 0.0765
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.0429 0.0481
Leishmania major hypothetical protein, unknown function 0.006 0.0119 0.0209
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0272 0.0968
Leishmania major kinesin, putative 0.014 0.0634 0.2151
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0041 0.0036
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0046 0.0026 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0074 0.0238
Trypanosoma brucei kinesin, putative 0.014 0.0634 0.2151
Onchocerca volvulus 0.0109 0.0429 0.2255
Trypanosoma cruzi cysteine proteinase, putative 0.0053 0.0074 0.0072
Trichomonas vaginalis calmodulin, putative 0.0044 0.0012 0.0007
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1397 0.8718 1
Brugia malayi calpain 5 0.006 0.0119 0.0125
Loa Loa (eye worm) myosin Light Chain family member 0.0044 0.0012 0.0002
Brugia malayi beta-lactamase family protein 0.0109 0.0429 0.0481
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0123
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0029 0.0019
Entamoeba histolytica cysteine protease, putative 0.0053 0.0074 0.0564
Schistosoma mansoni chromobox protein 0.0084 0.0272 0.0312
Echinococcus multilocularis cysteine protease 0.0064 0.0145 0.0135
Entamoeba histolytica cysteine protease, putative 0.0046 0.0026 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0097 0.0321
Trypanosoma brucei calpain-like protein, putative 0.0201 0.1022 0.3615
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0074 0.0042
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0209
Giardia lamblia Cathepsin L precursor 0.0046 0.0026 0.0053
Leishmania major cathepsin L-like protease 0.0064 0.0145 0.0308
Brugia malayi calpain D 0.006 0.0119 0.0125
Loa Loa (eye worm) hypothetical protein 0.0186 0.093 0.1057
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0097 0.0321
Giardia lamblia Cathepsin B precursor 0.0464 0.2714 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0216 0.1122 0.4111
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0019
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0026 0.003
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0046 0.0026 0.0019
Echinococcus granulosus chromobox protein 1 0.0084 0.0272 0.0301
Entamoeba histolytica grainin 2 0.0078 0.023 0.1968
Trypanosoma cruzi centrin, putative 0.0078 0.023 0.0251
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0566 0.3371 0.386
Entamoeba histolytica calpain large subunit domain III containing protein 0.014 0.0634 0.5601
Trichomonas vaginalis centrin, putative 0.0044 0.0012 0.0007
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0209
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.006 0.0119 0.0123
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0216 0.1122 0.1275
Trypanosoma cruzi centrin, putative 0.0078 0.023 0.0251
Loa Loa (eye worm) hypothetical protein 0.0044 0.0012 0.0002
Echinococcus multilocularis geminin 0.0522 0.3087 0.308
Leishmania major cathepsin L-like protease 0.0064 0.0145 0.0308
Echinococcus multilocularis programmed cell death protein 0.0078 0.023 0.022
Trypanosoma brucei cysteine peptidase, putative 0.006 0.0119 0.0209
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0201 0.1022 0.3615

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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