TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 391.46 | Formula: C19H22FN3O3S
H donors: 1 H acceptors: 2 LogP: 4.65 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC1CCCN(C1C)C(=O)c1nc(sc1C)Nc1cc2OCOc2cc1F
InChi: 1S/C19H22FN3O3S/c1-10-5-4-6-23(11(10)2)18(24)17-12(3)27-19(22-17)21-14-8-16-15(7-13(14)20)25-9-26-16/h7-8,10-11H,4-6,9H2,1-3H3,(H,21,22)
InChiKey: SEMFMCZEFJOTEB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	transient receptor potential cation channel, subfamily C, member 6	Starlite/ChEMBL	References
Homo sapiens	transient receptor potential cation channel, subfamily C, member 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131097	All targets in OG5_131097
Schistosoma japonicum	Short transient receptor potential channel 3, putative	Get druggable targets OG5_131097	All targets in OG5_131097
Echinococcus multilocularis	short transient receptor potential channel 6	Get druggable targets OG5_131097	All targets in OG5_131097
Schistosoma japonicum	Transient receptor potential-gamma protein, putative	Get druggable targets OG5_131097	All targets in OG5_131097
Schistosoma mansoni	transient receptor potential channel	Get druggable targets OG5_131097	All targets in OG5_131097
Echinococcus granulosus	short transient receptor potential channel 6	Get druggable targets OG5_131097	All targets in OG5_131097
Schistosoma japonicum	Short transient receptor potential channel 7, putative	Get druggable targets OG5_131097	All targets in OG5_131097

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	short transient receptor potential channel 6	transient receptor potential cation channel, subfamily C, member 6	931 aa	772 aa	32.5 %
Echinococcus granulosus	short transient receptor potential channel 6	transient receptor potential cation channel, subfamily C, member 3	921 aa	785 aa	31.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0155	0.1443	0.256
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0057	0.0169	0.0169
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0057	0.0169	0.0595
Brugia malayi	fibroinase precursor	0.0057	0.0169	0.018
Schistosoma mansoni	calpain (C02 family)	0.0288	0.3186	0.3189
Schistosoma mansoni	transient receptor potential channel	0.0383	0.4434	0.4438
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0221	0.2312	0.8145
Giardia lamblia	Cathepsin L precursor	0.0057	0.0169	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0155	0.1443	0.1534
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0169	0.0595
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0221	0.2312	0.8145
Loa Loa (eye worm)	hypothetical protein	0.0763	0.9408	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0286	0.0304
Trichomonas vaginalis	calmodulin, putative	0.0045	0.0009	0.0033
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0288	0.3186	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.0625
Giardia lamblia	Cathepsin L-like protease	0.0057	0.0169	0.0564
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0057	0.0169	0.0169
Toxoplasma gondii	proteasome subunit beta type, putative	0.023	0.2428	0.8552
Toxoplasma gondii	calcium-dependent protein kinase	0.0045	0.0009	0.0033
Onchocerca volvulus		0.0057	0.0169	0.03
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.1726
Toxoplasma gondii	aspartyl protease ASP1	0.0048	0.0041	0.0143
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0221	0.2312	0.7259
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.1726
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0057	0.0169	0.018
Echinococcus granulosus	proteasome prosome macropain	0.023	0.2428	0.2428
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0221	0.2312	0.9524
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0057	0.0169	0.0169
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.055	0.1937
Schistosoma mansoni	transient receptor potential channel 4	0.0116	0.094	0.0941
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0286	0.0304
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0221	0.2312	0.8145
Brugia malayi	Cathepsin L-like precursor	0.0221	0.2312	0.2458
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0286	0.0304
Plasmodium falciparum	proteasome subunit beta type-5	0.023	0.2428	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0057	0.0169	0.053
Schistosoma mansoni	caspase-7 (C14 family)	0.0059	0.0186	0.0186
Plasmodium falciparum	serine repeat antigen 1	0.0057	0.0169	0.0696
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0048	0.0041	0.0143
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0057	0.0169	0.0169
Brugia malayi	Cathepsin L-like precursor	0.0221	0.2312	0.2458
Giardia lamblia	Cathepsin B precursor	0.0057	0.0169	0.0564
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0155	0.1443	0.1534
Echinococcus multilocularis	cathepsin b	0.0717	0.8802	0.8802
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0288	0.3186	0.3619
Onchocerca volvulus		0.0066	0.0286	0.0507
Entamoeba histolytica	cysteine proteinase, putative	0.0221	0.2312	0.9524
Schistosoma mansoni	calpain-7 (C02 family)	0.0288	0.3186	0.3189
Onchocerca volvulus		0.0221	0.2312	0.4101
Brugia malayi	Cell death protein 3 precursor	0.0059	0.0186	0.0197
Trypanosoma brucei	calpain-like protein, putative	0.0288	0.3186	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0221	0.2312	0.2312
Trypanosoma cruzi	cysteine protease, putative	0.0124	0.1038	0.1179
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0288	0.3186	0.3619
Plasmodium vivax	vivapain-2	0.0221	0.2312	0.7259
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0057	0.0169	0.018
Entamoeba histolytica	cysteine protease, putative	0.0124	0.1038	0.4275
Echinococcus multilocularis	cathepsin L	0.0124	0.1038	0.1038
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0169	0.0595
Trypanosoma brucei	kinesin, putative	0.0201	0.2053	0.6443
Plasmodium vivax	unspecified product	0.0124	0.1038	0.3258
Echinococcus multilocularis	transient receptor potential gamma protein	0.0116	0.094	0.094
Giardia lamblia	Cathepsin B precursor	0.0261	0.2839	1
Brugia malayi	calpain family protein 1	0.0763	0.9408	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0221	0.2312	0.8145
Giardia lamblia	Cathepsin L precursor	0.0057	0.0169	0.0564
Echinococcus multilocularis	short transient receptor potential channel 6	0.0116	0.094	0.094
Plasmodium falciparum	plasmepsin I	0.0048	0.0041	0.0167
Giardia lamblia	Cathepsin L precursor	0.0057	0.0169	0.0564
Brugia malayi	calpain family protein 1	0.0763	0.9408	1
Onchocerca volvulus		0.0066	0.0286	0.0507
Entamoeba histolytica	protein kinase, putative	0.0201	0.2053	0.8455
Loa Loa (eye worm)	calpain family protein 1	0.0763	0.9408	1
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein	0.0064	0.0256	0.0272
Brugia malayi	cathepsin L-like precursor	0.0155	0.1443	0.1534
Plasmodium falciparum	serine repeat antigen 4	0.0057	0.0169	0.0696
Schistosoma mansoni	cathepsin s	0.0066	0.0286	0.0286
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0124	0.1038	0.3656
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0086	0.055	0.0625
Echinococcus multilocularis	short transient receptor potential channel 6	0.0383	0.4434	0.4434
Echinococcus granulosus	peroxidasin	0.0066	0.0286	0.0286
Loa Loa (eye worm)	animal heme peroxidase	0.0066	0.0286	0.0304
Giardia lamblia	Cathepsin B precursor	0.0057	0.0169	0.0564
Echinococcus granulosus	transient receptor potential ion channel A	0.011	0.0863	0.0863
Entamoeba histolytica	cysteine protease, putative	0.0221	0.2312	0.9524
Echinococcus granulosus	cathepsin b	0.0717	0.8802	0.8802
Trypanosoma cruzi	conserved protein	0.0086	0.055	0.0625
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0169	0.0595
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0288	0.3186	0.3189
Brugia malayi	calpain 5	0.0086	0.055	0.0584
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0288	0.3186	1
Echinococcus multilocularis	calbindin 32	0.0045	0.0009	0.0009
Brugia malayi	Papain family cysteine protease containing protein	0.0057	0.0169	0.018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0221	0.2312	0.8145
Schistosoma mansoni	cathepsin C	0.0057	0.0169	0.0169
Brugia malayi	Peroxidasin	0.0066	0.0286	0.0304
Giardia lamblia	Encystation-specific protease	0.0057	0.0169	0.0564
Brugia malayi	cathepsin B-like cysteine proteinase	0.0717	0.8802	0.9356
Entamoeba histolytica	cysteine protease, putative	0.0124	0.1038	0.4275
Schistosoma mansoni	peroxidasin	0.0066	0.0286	0.0286
Onchocerca volvulus	Peroxidasin homolog	0.0066	0.0286	0.0507
Trypanosoma brucei	calpain, putative	0.0086	0.055	0.1726
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0057	0.0169	0.053
Schistosoma mansoni	cathepsin F (C01 family)	0.0155	0.1443	0.1445
Entamoeba histolytica	cysteine protease, putative	0.0124	0.1038	0.4275
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.1726
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0221	0.2312	0.8145
Onchocerca volvulus		0.0221	0.2312	0.4101
Echinococcus multilocularis	calcium uptake protein 1	0.0045	0.0009	0.0009
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0261	0.2839	0.8912
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0221	0.2312	0.8145
Schistosoma mansoni	calcium binding atopy-related autoantigen	0.0045	0.0009	0.0009
Trypanosoma cruzi	cruzipain precursor, putative	0.0221	0.2312	0.2627
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0155	0.1443	0.164
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.0945	0.1004
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0057	0.0169	0.0169
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0048	0.0041	0.0041
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0062	0.0231	0.0246
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.0625
Trypanosoma brucei	Calpain-like protein CALP1.3	0.0086	0.055	0.1726
Schistosoma mansoni	peptidyl-glycine monooxygenase	0.0238	0.253	0.2532
Entamoeba histolytica	cysteine protease, putative	0.0057	0.0169	0.0696
Echinococcus multilocularis	calpain A	0.0808	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0124	0.1038	0.4275
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0057	0.0169	0.053
Brugia malayi	MH2 domain containing protein	0.0117	0.0945	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0155	0.1443	0.1534
Loa Loa (eye worm)	hypothetical protein	0.011	0.0863	0.0918
Plasmodium vivax	plasmepsin IV, putative	0.0048	0.0041	0.0127
Loa Loa (eye worm)	animal heme peroxidase	0.0066	0.0286	0.0304
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.0945	0.1004
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0221	0.2312	0.9524
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0124	0.1038	0.3258
Loa Loa (eye worm)	ctsf protein	0.0221	0.2312	0.2458
Trypanosoma brucei	Calpain-like protein 1.1	0.0086	0.055	0.1726
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0221	0.2312	0.7259
Entamoeba histolytica	cysteine protease, putative	0.0057	0.0169	0.0696
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0288	0.3186	0.3619
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0221	0.2312	0.8145
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0286	0.0304
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.023	0.2428	0.8552
Echinococcus granulosus	short transient receptor potential channel 6	0.0383	0.4434	0.4434
Entamoeba histolytica	cysteine protease, putative	0.0124	0.1038	0.4275
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0169	0.0595
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0221	0.2312	0.8145
Echinococcus granulosus	calpain 7 C02 family	0.0288	0.3186	0.3186
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0221	0.2312	0.8145
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0086	0.055	0.1937
Echinococcus multilocularis	proteasome (prosome, macropain)	0.023	0.2428	0.2428
Brugia malayi	Animal haem peroxidase family protein	0.0066	0.0286	0.0304
Giardia lamblia	Hypothetical protein	0.0057	0.0169	0.0564
Entamoeba histolytica	cysteine protease, putative	0.0057	0.0169	0.0696
Giardia lamblia	Cysteine protease	0.0057	0.0169	0.0564
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0261	0.2839	0.8912
Trypanosoma brucei	calmodulin, putative	0.0045	0.0009	0.0029
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0045	0.0009	0.0011
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.1726
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0221	0.2312	0.7259
Trypanosoma cruzi	cysteine peptidase, putative	0.0221	0.2312	0.2627
Loa Loa (eye worm)	cathepsin B	0.0261	0.2839	0.3018
Onchocerca volvulus		0.0221	0.2312	0.4101
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0086	0.055	0.0625
Schistosoma mansoni	cathepsin D (A01 family)	0.014	0.1256	0.1257
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0286	0.0304
Mycobacterium ulcerans	proteasome PrcB	0.023	0.2428	0.5
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0221	0.2312	0.2458
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0221	0.2312	0.7259
Entamoeba histolytica	cysteine proteinase, putative	0.0124	0.1038	0.4275
Schistosoma mansoni	calpain-2 (C02 family)	0.0086	0.055	0.055
Trypanosoma brucei	calpain-like protein, putative	0.0288	0.3186	1
Brugia malayi	Papain family cysteine protease containing protein	0.0124	0.1038	0.1103
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0057	0.0169	0.0169
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0221	0.2312	0.8145
Entamoeba histolytica	cysteine protease, putative	0.0124	0.1038	0.4275
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0221	0.2312	0.8145
Plasmodium falciparum	serine repeat antigen 7	0.0057	0.0169	0.0696
Onchocerca volvulus	Cathepsin L homolog	0.0057	0.0169	0.03
Leishmania major	cathepsin L-like protease	0.0221	0.2312	0.7259
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.1726
Trypanosoma cruzi	cysteine peptidase, putative	0.0221	0.2312	0.2627
Echinococcus multilocularis	cathepsin L cysteine protease	0.0221	0.2312	0.2312
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0057	0.0169	0.0169
Onchocerca volvulus	Peroxidase homolog	0.0066	0.0286	0.0507
Echinococcus multilocularis	cathepsin L	0.0057	0.0169	0.0169
Plasmodium vivax	hypothetical protein, conserved	0.0045	0.0009	0.0029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0169	0.0595
Giardia lamblia	Cathepsin B precursor	0.0261	0.2839	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.055	0.0584
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.023	0.2428	0.8547
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0124	0.1038	0.1179
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0169	0.0595
Plasmodium falciparum	serine repeat antigen 8	0.0057	0.0169	0.0696
Trypanosoma cruzi	cysteine peptidase, putative	0.0221	0.2312	0.2627
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0057	0.0169	0.053
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0286	0.0304
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0807	0.9991	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0057	0.0169	0.0192
Entamoeba histolytica	cysteine protease, putative	0.0124	0.1038	0.4275
Entamoeba histolytica	cysteine protease, putative	0.0124	0.1038	0.4275
Brugia malayi	cathepsin F-like cysteine proteinase	0.0066	0.0286	0.0304
Leishmania major	cathepsin L-like protease	0.0221	0.2312	0.7259
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0066	0.0286	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0286	0.0304
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0048	0.0041	0.0143
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.0625
Trypanosoma cruzi	cysteine proteinase, putative	0.0124	0.1038	0.1179
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0221	0.2312	0.8145
Plasmodium falciparum	serine repeat antigen 6	0.0057	0.0169	0.0696
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0057	0.0169	0.0696
Echinococcus multilocularis	calpain 5	0.0288	0.3186	0.3186
Schistosoma mansoni	transient receptor potential channel	0.0116	0.094	0.0941
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.023	0.2428	0.2581
Plasmodium falciparum	calpain	0.0086	0.055	0.2265
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.1726
Loa Loa (eye worm)	animal heme peroxidase	0.0066	0.0286	0.0304
Plasmodium falciparum	plasmepsin IV	0.0048	0.0041	0.0167
Entamoeba histolytica	calpain family cysteine protease, putative	0.0086	0.055	0.2265
Leishmania major	hypothetical protein, conserved	0.0086	0.055	0.1726
Trypanosoma cruzi	cysteine peptidase, putative	0.0221	0.2312	0.2627
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0288	0.3186	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0057	0.0169	0.0696
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0057	0.0169	0.053
Plasmodium vivax	proteasome subunit beta type-5, putative	0.023	0.2428	0.7621
Echinococcus multilocularis	peroxidasin	0.0066	0.0286	0.0286
Brugia malayi	Papain family cysteine protease containing protein	0.0221	0.2312	0.2458
Toxoplasma gondii	cathepsin CPC1	0.0057	0.0169	0.0595
Entamoeba histolytica	cysteine proteinase 2	0.0124	0.1038	0.4275
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0221	0.2312	0.8145
Plasmodium vivax	calpain, putative	0.0288	0.3186	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.1726
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0221	0.2312	0.8145
Toxoplasma gondii	hypothetical protein	0.0086	0.055	0.1937
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0169	0.0595
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0286	0.0325
Brugia malayi	Animal haem peroxidase family protein	0.0066	0.0286	0.0304
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0201	0.2053	0.8455
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.023	0.2428	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0221	0.2312	0.7259
Brugia malayi	Papain family cysteine protease containing protein	0.0057	0.0169	0.018
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0717	0.8802	0.881
Echinococcus multilocularis	cathepsin b	0.0717	0.8802	0.8802
Plasmodium vivax	unspecified product	0.0066	0.0286	0.0897
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0048	0.0041	0.0041
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0221	0.2312	0.8145
Leishmania major	kinesin, putative	0.0201	0.2053	0.6443
Schistosoma mansoni	peroxidasin	0.0066	0.0286	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0155	0.1443	0.1534
Trypanosoma cruzi	major cysteine proteinase, putative	0.0057	0.0169	0.0192
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0261	0.2839	0.3225
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0057	0.0169	0.0696
Onchocerca volvulus		0.0221	0.2312	0.4101
Trypanosoma brucei	antigen, putative	0.0288	0.3186	1
Loa Loa (eye worm)	animal heme peroxidase	0.0066	0.0286	0.0304
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0717	0.8802	0.881
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0057	0.0169	0.0564
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0221	0.2312	0.2312
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.023	0.2428	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.0057	0.0169	0.018
Giardia lamblia	Cysteine protease	0.0057	0.0169	0.0564
Onchocerca volvulus		0.0045	0.0009	0.0017
Plasmodium falciparum	serine repeat antigen 2	0.0057	0.0169	0.0696
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0124	0.1038	0.1039
Giardia lamblia	Cathepsin B precursor	0.0057	0.0169	0.0564
Onchocerca volvulus		0.0475	0.5639	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.1726
Leishmania major	cathepsin L-like protease	0.0221	0.2312	0.7259
Brugia malayi	calpain D	0.0086	0.055	0.0584
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0057	0.0169	0.0595
Onchocerca volvulus	Chorion peroxidase homolog	0.0066	0.0286	0.0507
Echinococcus granulosus	calpain	0.0288	0.3186	0.3186
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0221	0.2312	0.9524
Loa Loa (eye worm)	calpain	0.0288	0.3186	0.3386
Brugia malayi	Papain family cysteine protease containing protein	0.0124	0.1038	0.1103
Leishmania major	cathepsin L-like protease	0.0221	0.2312	0.7259
Trypanosoma brucei	calpain-like protein, putative	0.0288	0.3186	1
Trypanosoma cruzi	kinesin, putative	0.0201	0.2053	0.2332
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.0625
Brugia malayi	Cathepsin L-like precursor	0.0066	0.0286	0.0304
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.1726
Onchocerca volvulus		0.0066	0.0286	0.0507
Trypanosoma brucei	glucosamine 6-phosphate n-acetyltransferase	0.0086	0.055	0.1726
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0286	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0169	0.018
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0057	0.0169	0.018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0221	0.2312	0.8145
Trypanosoma cruzi	cruzipain precursor, putative	0.0066	0.0286	0.0325
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.1726
Brugia malayi	cathepsin L-like cysteine proteinase	0.0057	0.0169	0.018
Entamoeba histolytica	cysteine protease, putative	0.0057	0.0169	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0286	0.0304
Brugia malayi	Cathepsin L-like precursor	0.0221	0.2312	0.2458
Entamoeba histolytica	cysteine protease, putative	0.0124	0.1038	0.4275
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0057	0.0169	0.053
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0261	0.2839	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0124	0.1038	0.4275
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0169	0.0595
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0124	0.1038	0.3656
Plasmodium falciparum	serine repeat antigen 9	0.0057	0.0169	0.0696
Echinococcus granulosus	cathepsin L cysteine protease	0.0124	0.1038	0.1038
Loa Loa (eye worm)	cysteine protease	0.0221	0.2312	0.2458
Giardia lamblia	Hypothetical protein	0.0057	0.0169	0.0564
Onchocerca volvulus	Cathepsin L homolog	0.0221	0.2312	0.4101
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0057	0.0169	0.018
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0286	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0169	0.018
Giardia lamblia	Cathepsin B precursor	0.0057	0.0169	0.0564
Leishmania major	hypothetical protein, unknown function	0.0086	0.055	0.1726
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0221	0.2312	0.7259
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0286	0.0304
Toxoplasma gondii	cathepsin CPC2	0.0057	0.0169	0.0595
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0221	0.2312	0.7259
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0221	0.2312	0.8145
Entamoeba histolytica	cysteine protease, putative	0.0124	0.1038	0.4275
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0057	0.0169	0.0564
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0086	0.055	0.1937
Loa Loa (eye worm)	blistered cuticle protein 3	0.0066	0.0286	0.0304
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0221	0.2312	0.7259
Schistosoma mansoni	dopamine-beta-monooxygenase	0.0126	0.107	0.1071
Plasmodium vivax	serine-repeat antigen (SERA)	0.0057	0.0169	0.053
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0807	0.9991	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.1726
Brugia malayi	Proteasome A-type and B-type family protein	0.023	0.2428	0.2581
Entamoeba histolytica	cysteine protease, putative	0.0057	0.0169	0.0696
Echinococcus granulosus	calpain 5	0.0288	0.3186	0.3186
Schistosoma mansoni	cathepsin S (C01 family)	0.0057	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0116	0.094	0.0999
Echinococcus multilocularis	transient receptor potential ion channel A	0.011	0.0863	0.0863
Brugia malayi	EF hand family protein	0.0045	0.0009	0.001
Brugia malayi	Cathepsin L-like precursor	0.0221	0.2312	0.2458
Giardia lamblia	Cathepsin L precursor	0.0057	0.0169	0.0564
Echinococcus granulosus	cathepsin L	0.0057	0.0169	0.0169
Echinococcus granulosus	calpain A	0.0288	0.3186	0.3186
Entamoeba histolytica	cysteine proteinase, putative	0.0124	0.1038	0.4275
Trypanosoma brucei	Calpain-like protein 1.2	0.0086	0.055	0.1726
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0057	0.0169	0.0595
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.0625
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0221	0.2312	0.2312
Onchocerca volvulus	Cathepsin L homolog	0.0221	0.2312	0.4101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0169	0.0595
Entamoeba histolytica	grainin, putative	0.0045	0.0009	0.0038
Brugia malayi	Animal haem peroxidase family protein	0.0066	0.0286	0.0304
Brugia malayi	Blistered cuticle protein 3	0.0066	0.0286	0.0304
Plasmodium falciparum	serine repeat antigen 5	0.0057	0.0169	0.0696
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0057	0.0169	0.0595
Leishmania major	cathepsin L-like protease	0.0221	0.2312	0.7259
Echinococcus multilocularis	peptidyl glycine alpha amidating monooxygenase	0.0238	0.253	0.253
Giardia lamblia	Cathepsin B precursor	0.0057	0.0169	0.0564
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0717	0.8802	1
Leishmania major	proteasome beta 5 subunit, putative	0.023	0.2428	0.7621
Echinococcus multilocularis	calpain 7 (C02 family)	0.0288	0.3186	0.3186
Giardia lamblia	Cysteine protease	0.0057	0.0169	0.0564
Schistosoma mansoni	cathepsin F (C01 family)	0.0221	0.2312	0.2314
Plasmodium vivax	vivapain-2	0.0221	0.2312	0.7259
Echinococcus granulosus	cathepsin l1	0.0221	0.2312	0.2312
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0221	0.2312	0.8145
Toxoplasma gondii	calmodulin CAM1	0.0045	0.0009	0.0033
Echinococcus granulosus	cathepsin l1	0.0155	0.1443	0.1443
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0717	0.8802	0.881
Echinococcus multilocularis	calumenin	0.0045	0.0009	0.0009
Entamoeba histolytica	hypothetical protein, conserved	0.0045	0.0009	0.0038
Schistosoma mansoni	peptidylglycine monooxygenase	0.0126	0.107	0.1071
Echinococcus granulosus	calcium uptake protein 1	0.0045	0.0009	0.0009
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.1726
Plasmodium vivax	vivapain-3	0.0124	0.1038	0.3258
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0086	0.055	0.1937
Brugia malayi	calpain 7	0.0288	0.3186	0.3386
Trypanosoma brucei	hypothetical protein	0.0086	0.055	0.1726
Trichomonas vaginalis	calpain, putative	0.0086	0.055	0.1937
Entamoeba histolytica	cysteine protease, putative	0.0124	0.1038	0.4275
Trypanosoma brucei	calpain-like protein, putative	0.0288	0.3186	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.1726
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0763	0.9408	0.9416
Onchocerca volvulus		0.0221	0.2312	0.4101
Brugia malayi	cathepsin F-like cysteine proteinase	0.0057	0.0169	0.018
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.1726
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0057	0.0169	0.0564
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0086	0.055	0.0625
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0288	0.3186	0.3619
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0086	0.055	0.1937
Echinococcus multilocularis	caspase 2	0.0059	0.0186	0.0186
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.1726
Echinococcus multilocularis	EF hand domain containing family member A2	0.0045	0.0009	0.0009
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0288	0.3186	0.3619
Echinococcus granulosus	short transient receptor potential channel 6	0.0116	0.094	0.094
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.023	0.2428	0.7621
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0057	0.0169	0.018
Brugia malayi	Animal haem peroxidase family protein	0.0066	0.0286	0.0304
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0169	0.0595
Entamoeba histolytica	cysteine protease, putative	0.0124	0.1038	0.4275
Leishmania major	hypothetical protein, conserved	0.0045	0.0009	0.0029
Trichomonas vaginalis	calpain, putative	0.0086	0.055	0.1937
Loa Loa (eye worm)	hypothetical protein	0.0676	0.8275	0.8796
Leishmania major	cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.1726
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0221	0.2312	0.2312
Echinococcus multilocularis	calpain	0.0288	0.3186	0.3186
Loa Loa (eye worm)	hypothetical protein	0.0475	0.5639	0.5994
Entamoeba histolytica	hypothetical protein	0.0057	0.0169	0.0696
Echinococcus granulosus	cathepsin L	0.0124	0.1038	0.1038
Loa Loa (eye worm)	hypothetical protein	0.0126	0.107	0.1138
Plasmodium falciparum	serine repeat antigen 3	0.0057	0.0169	0.0696
Schistosoma mansoni	cathepsin D (A01 family)	0.014	0.1256	0.1257
Plasmodium vivax	aspartyl proteinase, putative	0.0048	0.0041	0.0127
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0086	0.055	0.0625
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0288	0.3186	0.3619
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0717	0.8802	0.881
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0057	0.0169	0.0595
Onchocerca volvulus	Peroxidasin homolog	0.0066	0.0286	0.0507
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0221	0.2312	0.8145
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0048	0.0041	0.0043
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0048	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0221	0.2312	0.2458
Trypanosoma brucei	calpain, putative	0.0086	0.055	0.1726
Loa Loa (eye worm)	hypothetical protein	0.0238	0.253	0.2689
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0086	0.055	0.0625
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.0625
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0057	0.0169	0.0595
Giardia lamblia	Cathepsin L precursor	0.0057	0.0169	0.0564
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0155	0.1443	0.5084
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0041	0.0043
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0221	0.2312	0.8145
Plasmodium vivax	vivapain-1	0.0124	0.1038	0.3258
Brugia malayi	Cathepsin L-like precursor	0.0221	0.2312	0.2458
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.023	0.2428	0.2758
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0124	0.1038	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0186	0.0197
Onchocerca volvulus		0.0221	0.2312	0.4101
Plasmodium vivax	serine-repeat antigen (SERA)	0.0057	0.0169	0.053
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0057	0.0169	0.0696
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0057	0.0169	0.0564
Onchocerca volvulus	Dual oxidase homolog	0.0066	0.0286	0.0507
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0124	0.1038	0.4275
Entamoeba histolytica	cysteine proteinase, putative	0.0221	0.2312	0.9524
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0286	0.0304
Echinococcus multilocularis	cysteine protease	0.0221	0.2312	0.2312
Trichomonas vaginalis	hypothetical protein	0.0086	0.055	0.1937
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.023	0.2428	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0057	0.0169	0.0169
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0057	0.0169	0.0169
Toxoplasma gondii	cathepsin B	0.0261	0.2839	1
Brugia malayi	Cathepsin L-like precursor	0.0221	0.2312	0.2458
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0221	0.2312	0.7259
Entamoeba histolytica	cysteine proteinase, putative	0.0124	0.1038	0.4275
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.1726
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0057	0.0169	0.053
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0261	0.2839	0.2842
Leishmania major	cathepsin L-like protease	0.0221	0.2312	0.7259
Giardia lamblia	Cysteine protease	0.0057	0.0169	0.0564
Toxoplasma gondii	cathepsin CPL	0.0221	0.2312	0.8145
Brugia malayi	calpain 5	0.0201	0.2053	0.2182
Loa Loa (eye worm)	hypothetical protein	0.0717	0.8802	0.9356
Schistosoma mansoni	calpain C (C02 family)	0.0288	0.3186	0.3189
Plasmodium falciparum	plasmepsin VI	0.0048	0.0041	0.0167
Echinococcus granulosus	transient receptor potential gamma protein	0.0116	0.094	0.094
Entamoeba histolytica	cysteine protease, putative	0.0057	0.0169	0.0696
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0126	0.107	0.1138
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0124	0.1038	0.3258
Schistosoma mansoni	transient receptor potential channel	0.0116	0.094	0.0941
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0169	0.018
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0807	0.9991	0.9991
Echinococcus multilocularis	hypothetical protein	0.0288	0.3186	0.3186
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0288	0.3186	0.3619
Trypanosoma cruzi	cysteine peptidase, putative	0.0124	0.1038	0.1179
Trypanosoma brucei	cysteine peptidase, putative	0.0086	0.055	0.1726
Loa Loa (eye worm)	calpain family protein 1	0.0562	0.6772	0.7198
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0288	0.3186	1
Toxoplasma gondii	calpain family cysteine protease domain-containing protein	0.0086	0.055	0.1937
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0057	0.0169	0.053
Loa Loa (eye worm)	hypothetical protein	0.0562	0.6772	0.7198
Loa Loa (eye worm)	fibroinase	0.0221	0.2312	0.2458
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0086	0.055	0.1937
Trypanosoma brucei	cytoskeleton-associated protein CAP5.5, putative	0.0086	0.055	0.1726
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0086	0.055	0.1937
Entamoeba histolytica	cysteine protease, putative	0.0124	0.1038	0.4275
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0238	0.253	0.2689
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0057	0.0169	0.0696
Leishmania major	cysteine peptidase A (CPA)	0.0221	0.2312	0.7259
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0086	0.055	0.0625
Onchocerca volvulus	Peroxidase homolog	0.0066	0.0286	0.0507
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0066	0.0286	0.0304
Trypanosoma cruzi	cysteine proteinase, putative	0.0124	0.1038	0.1179
Brugia malayi	cathepsin L precursor	0.0057	0.0169	0.018
Schistosoma mansoni	hypothetical protein	0.0086	0.055	0.055
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0086	0.055	0.1726
Entamoeba histolytica	cysteine protease, putative	0.0124	0.1038	0.4275
Leishmania major	calpain protease-like protein	0.0086	0.055	0.1726
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0169	0.018
Echinococcus granulosus	EF hand domain containing family member A2	0.0045	0.0009	0.0009
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.023	0.2428	0.243
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.0625
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0057	0.0169	0.0595
Giardia lamblia	Cathepsin L-like protease	0.0057	0.0169	0.0564
Leishmania major	calpain family cysteine protease-like protein	0.0086	0.055	0.1726
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0057	0.0169	0.0169
Leishmania major	cathepsin L-like protease	0.0221	0.2312	0.7259
Loa Loa (eye worm)	programmed cell death protein 6	0.0045	0.0009	0.001
Echinococcus granulosus	peptidyl glycine alpha amidating monooxygenase	0.0238	0.253	0.253
Trichomonas vaginalis	calcineurin B subunit, putative	0.0045	0.0009	0.0033
Trichomonas vaginalis	calpain, putative	0.0086	0.055	0.1937
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0169	0.018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0221	0.2312	0.8145
Echinococcus granulosus	calbindin 32	0.0045	0.0009	0.0009
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0221	0.2312	0.8145
Onchocerca volvulus	Cell death protein 3 homolog	0.0059	0.0186	0.0329
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0057	0.0169	0.053
Echinococcus multilocularis	cathepsin L cysteine protease	0.0221	0.2312	0.2312
Loa Loa (eye worm)	calpain 5	0.0201	0.2053	0.2182
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0086	0.055	0.0625
Schistosoma mansoni	cathepsin F (C01 family)	0.0221	0.2312	0.2314
Schistosoma mansoni	calpain-7 (C02 family)	0.0288	0.3186	0.3189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0221	0.2312	0.8145
Entamoeba histolytica	cysteine proteinase, putative	0.0155	0.1443	0.5945
Echinococcus granulosus	calumenin	0.0045	0.0009	0.0009
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0288	0.3186	0.3619
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0288	0.3186	0.3619
Echinococcus multilocularis	cysteine protease	0.0221	0.2312	0.2312
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0286	0.0304
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0057	0.0169	0.053
Plasmodium falciparum	plasmepsin II	0.0048	0.0041	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0286	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0286	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0169	0.018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0221	0.2312	0.8145
Leishmania major	calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.1726
Echinococcus granulosus	cysteine protease	0.0124	0.1038	0.1038
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.0625
Brugia malayi	Cathepsin L-like precursor	0.0155	0.1443	0.1534
Echinococcus granulosus	cathepsin b	0.0717	0.8802	0.8802
Onchocerca volvulus	Cathepsin F homolog	0.0221	0.2312	0.4101
Trypanosoma cruzi	kinesin, putative	0.0201	0.2053	0.2332
Leishmania major	cathepsin L-like protease	0.0221	0.2312	0.7259
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0169	0.0595
Onchocerca volvulus		0.0221	0.2312	0.4101
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0286	0.0304
Brugia malayi	Cathepsin L-like precursor	0.0155	0.1443	0.1534
Trypanosoma brucei	Calpain-like protein 2	0.0086	0.055	0.1726
Echinococcus multilocularis	calpain family protein 1, d	0.0562	0.6772	0.6772
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0155	0.1443	0.5084
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0288	0.3186	1
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0086	0.055	0.0625
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0221	0.2312	0.7259
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0057	0.0169	0.0595
Plasmodium vivax	unspecified product	0.0057	0.0169	0.053
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0221	0.2312	0.2458
Loa Loa (eye worm)	calpain D	0.0086	0.055	0.0584
Brugia malayi	Animal haem peroxidase family protein	0.0066	0.0286	0.0304
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0807	0.9991	0.9991
Schistosoma mansoni	reticulocalbin	0.0045	0.0009	0.0009
Giardia lamblia	Cathepsin L precursor	0.0057	0.0169	0.0564
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0288	0.3186	0.3619
Giardia lamblia	Cathepsin B precursor	0.0261	0.2839	1
Echinococcus granulosus	caspase 2	0.0059	0.0186	0.0186
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0221	0.2312	0.7259
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0086	0.055	0.0625
Brugia malayi	hypothetical protein	0.0066	0.0286	0.0304
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0086	0.055	0.1726
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0086	0.055	0.0625
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0057	0.0169	0.018
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0286	0.0304
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.023	0.2428	0.2758
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0057	0.0169	0.0595
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0124	0.1038	0.1039

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 25 nM	Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay	ChEMBL.	23886683
IC50 (binding)	= 160 nM	Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay	ChEMBL.	23886683

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2418808

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1768945