Detailed information for compound 185160

Basic information

Technical information
  • TDR Targets ID: 185160
  • Name: 7-bromo-3-(trifluoromethyl)-1,2,3,4-tetrahydr oisoquinoline
  • MW: 280.084 | Formula: C10H9BrF3N
  • H donors: 1 H acceptors: 0 LogP: 3.2 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc2c(c1)CNC(C2)C(F)(F)F
  • InChi: 1S/C10H9BrF3N/c11-8-2-1-6-4-9(10(12,13)14)15-5-7(6)3-8/h1-3,9,15H,4-5H2
  • InChiKey: PEEKNBLYJJEHJI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Phenylethanolamine N-methyltransferase Starlite/ChEMBL References
Homo sapiens adrenoceptor alpha 2A Starlite/ChEMBL References
Rattus norvegicus Adrenergic receptor alpha-2 Starlite/ChEMBL References
Homo sapiens phenylethanolamine N-methyltransferase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Putative Werner syndrome ATP-dependent helicase homolog 1 Phenylethanolamine N-methyltransferase   283 aa 254 aa 27.2 %
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein Phenylethanolamine N-methyltransferase   283 aa 245 aa 26.5 %
Brugia malayi NNMT/PNMT/TEMT family protein phenylethanolamine N-methyltransferase 282 aa 257 aa 26.5 %
Brugia malayi NNMT/PNMT/TEMT family protein Phenylethanolamine N-methyltransferase   283 aa 254 aa 26.0 %
Schistosoma mansoni amine GPCR Adrenergic receptor alpha-2   450 aa 439 aa 29.2 %
Onchocerca volvulus Adrenergic receptor alpha-2   450 aa 420 aa 19.8 %
Echinococcus multilocularis alpha 1A adrenergic receptor Adrenergic receptor alpha-2   450 aa 478 aa 20.7 %
Echinococcus multilocularis fmrfamide receptor Adrenergic receptor alpha-2   450 aa 366 aa 19.9 %
Echinococcus granulosus alpha 1A adrenergic receptor Adrenergic receptor alpha-2   450 aa 476 aa 21.0 %
Loa Loa (eye worm) TYRA-2 protein Adrenergic receptor alpha-2   450 aa 488 aa 23.8 %
Echinococcus multilocularis serotonin receptor Adrenergic receptor alpha-2   450 aa 426 aa 31.9 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Adrenergic receptor alpha-2   450 aa 378 aa 20.9 %
Echinococcus granulosus biogenic amine 5HT receptor Adrenergic receptor alpha-2   450 aa 423 aa 31.7 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Adrenergic receptor alpha-2   450 aa 473 aa 24.1 %
Onchocerca volvulus Adrenergic receptor alpha-2   450 aa 467 aa 25.1 %
Schistosoma mansoni biogenic amine (5HT) receptor Adrenergic receptor alpha-2   450 aa 433 aa 27.9 %
Echinococcus multilocularis neuropeptides capa receptor Adrenergic receptor alpha-2   450 aa 486 aa 20.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0165 0.0781 0.0781
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0158 0.0746 0.0799
Loa Loa (eye worm) TK/FER protein kinase 0.0151 0.0707 0.0707
Loa Loa (eye worm) TK/DDR protein kinase 0.0151 0.0707 0.0707
Brugia malayi angiogenesis inhibito 0.0026 0.003 0.0037
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Brugia malayi Integrin beta pat-3 precursor 0.0307 0.155 0.1951
Brugia malayi hypothetical protein 0.0092 0.0385 0.0484
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0151 0.0707 0.089
Entamoeba histolytica serine/threonine kinase, putative 0.0151 0.0707 0.9998
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0038
Echinococcus multilocularis tyrosine protein kinase Srms 0.0151 0.0707 0.089
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.1486 0.7945 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0151 0.0707 0.089
Toxoplasma gondii subtilisin SUB11 0.005 0.0157 0.0197
Leishmania major protein kinase, putative 0.0151 0.0707 0.089
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.1401 0.7482 1
Entamoeba histolytica hypothetical protein 0.0151 0.0707 0.9998
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0144 0.0669 0.0842
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0263 0.3714
Brugia malayi Peripheral plasma membrane protein CASK 0.0032 0.0059 0.0075
Echinococcus granulosus tyrosine protein kinase csk 0.0151 0.0707 0.089
Brugia malayi NNMT/PNMT/TEMT family protein 0.0667 0.3501 0.4407
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Echinococcus multilocularis insulin receptor 0.0151 0.0707 0.089
Echinococcus multilocularis heat shock protein 70 0.0151 0.0707 0.089
Plasmodium falciparum subtilisin-like protease 3 0.005 0.0157 0.0197
Echinococcus multilocularis leucine aminopeptidase protein 0.0115 0.0511 0.0643
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0292 0.1471 0.1852
Plasmodium falciparum plasmepsin IV 0.0165 0.0781 0.0983
Entamoeba histolytica protein kinase, putative 0.0151 0.0707 0.9998
Entamoeba histolytica tyrosine kinase, putative 0.0151 0.0707 0.9998
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0007 0.0009
Schistosoma mansoni ephrin receptor 0.0151 0.0707 0.0757
Schistosoma mansoni protein tyrosine kinase 0.0151 0.0707 0.0757
Toxoplasma gondii aminopeptidase n, putative 0.0343 0.1748 0.22
Brugia malayi aspartic protease BmAsp-2, identical 0.0092 0.0385 0.0484
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0151 0.0707 0.0707
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0121 0.0152
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0115 0.0511 0.0674
Loa Loa (eye worm) hypothetical protein 0.0151 0.0707 0.0707
Trypanosoma cruzi aminopeptidase, putative 0.0144 0.0669 0.0842
Echinococcus multilocularis tyrosine protein kinase pr2 0.0151 0.0707 0.089
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit beta 0.0292 0.1471 0.1378
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0029 0.0046 0.0058
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0292 0.1471 0.1959
Mycobacterium ulcerans aminopeptidase N PepN 0.0056 0.0193 0.0099
Echinococcus multilocularis tyrosine protein kinase csk 0.0151 0.0707 0.089
Schistosoma mansoni protein kinase 0.0151 0.0707 0.0757
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0151 0.0707 0.089
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0121 0.0161
Echinococcus multilocularis Furin 1 0.005 0.0157 0.0197
Echinococcus granulosus dna polymerase kappa 0.0043 0.0121 0.0152
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0092 0.0385 0.0412
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.005 0.0157 0.0197
Loa Loa (eye worm) guanylate kinase 0.0025 0.002 0.002
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Schistosoma mansoni hypothetical protein 0.0066 0.0245 0.0263
Echinococcus granulosus retinal guanylyl cyclase 2 0.0151 0.0707 0.089
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.005 0.0157 0.0197
Schistosoma mansoni cell polarity protein 0.0026 0.0031 0.0033
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0144 0.0669 0.0716
Loa Loa (eye worm) hypothetical protein 0.0045 0.0131 0.0131
Loa Loa (eye worm) endoprotease bli-4 0.005 0.0157 0.0157
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0029 0.0046 0.0061
Loa Loa (eye worm) subtilase 0.005 0.0157 0.0157
Entamoeba histolytica tyrosine kinase, putative 0.0151 0.0707 0.9998
Toxoplasma gondii flavodoxin domain-containing protein 0.0038 0.0093 0.0117
Loa Loa (eye worm) aminopeptidase N 0.0144 0.0669 0.0669
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0151 0.0707 0.0945
Giardia lamblia Hypothetical protein 0.0068 0.0254 0.3599
Echinococcus granulosus retinal guanylyl cyclase 2 0.0151 0.0707 0.089
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0151 0.0707 0.089
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0131 0.014
Echinococcus granulosus tyrosine protein kinase Fyn 0.0158 0.0746 0.0939
Brugia malayi hypothetical protein 0.0464 0.2405 0.3027
Plasmodium falciparum plasmepsin VI 0.0165 0.0781 0.0983
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0092 0.0385 0.0385
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0056 0.0193 0.0243
Onchocerca volvulus 0.0151 0.0707 0.2818
Loa Loa (eye worm) hypothetical protein 0.0096 0.0409 0.0409
Loa Loa (eye worm) guanylate kinase 0.006 0.0211 0.0211
Schistosoma mansoni integrin alpha-ps 0.0543 0.2828 0.303
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0292 0.1471 0.1804
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0157 0.0209
Schistosoma mansoni furin-1 (S08 family) 0.005 0.0157 0.0168
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0158 0.0746 0.0939
Loa Loa (eye worm) TK/FER protein kinase 0.0151 0.0707 0.0707
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0121 0.0152
Trypanosoma cruzi Aminopeptidase M1, putative 0.0144 0.0669 0.0842
Schistosoma mansoni tyrosine kinase 0.0158 0.0746 0.0799
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0151 0.0707 0.0707
Brugia malayi flavodoxin family protein 0.0029 0.0046 0.0058
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0151 0.0707 0.0707
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Loa Loa (eye worm) RGC/RGC protein kinase 0.0151 0.0707 0.0707
Echinococcus granulosus tyrosine protein kinase pr2 0.0151 0.0707 0.089
Plasmodium falciparum tyrosine kinase-like protein 0.0151 0.0707 0.089
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0263 0.0331
Schistosoma mansoni MAGUK homolog 0.0025 0.002 0.0022
Toxoplasma gondii aspartyl protease ASP3 0.0092 0.0385 0.0484
Loa Loa (eye worm) hypothetical protein 0.0151 0.0707 0.0707
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN) 0.0099 0.0424 0.0365
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.1486 0.7945 1
Echinococcus granulosus furin 0.005 0.0157 0.0197
Entamoeba histolytica tyrosin kinase, putative 0.0151 0.0707 0.9998
Brugia malayi hypothetical protein 0.0092 0.0385 0.0484
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0076 0.0302 0.038
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Plasmodium falciparum subtilisin-like protease 2 0.005 0.0157 0.0197
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0041 0.0041
Brugia malayi Tyrosine-protein kinase abl-1 0.0158 0.0746 0.0939
Echinococcus multilocularis kelch ECH associated protein 1 0.0093 0.0392 0.0494
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0142 0.0655 0.0824
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.005 0.0157 0.02
Plasmodium vivax aspartyl protease, putative 0.0092 0.0385 0.0429
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Entamoeba histolytica tyrosine kinase, putative 0.0151 0.0707 0.9998
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Brugia malayi ADAMTS-like protease 0.0026 0.003 0.0037
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0292 0.1471 0.1852
Loa Loa (eye worm) hypothetical protein 0.0088 0.0363 0.0363
Toxoplasma gondii leucyl aminopeptidase LAP 0.0115 0.0511 0.0643
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Entamoeba histolytica tyrosine kinase, putative 0.0151 0.0707 0.9998
Entamoeba histolytica tyrosine kinase, putative 0.0151 0.0707 0.9998
Schistosoma mansoni lamin 0.0028 0.0041 0.0044
Entamoeba histolytica cysteine surface protein, putative 0.0151 0.0707 0.9998
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0115 0.0511 0.0483
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.005 0.0157 0.0493
Loa Loa (eye worm) aspartyl protease 6 0.0092 0.0385 0.0385
Schistosoma mansoni hypothetical protein 0.0035 0.0076 0.0081
Echinococcus multilocularis natriuretic peptide receptor 1 0.0151 0.0707 0.089
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Onchocerca volvulus 0.0151 0.0707 0.2818
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0053 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Onchocerca volvulus 0.0151 0.0707 0.2818
Loa Loa (eye worm) TK/FER protein kinase 0.0151 0.0707 0.0707
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0059 0.0206 0.022
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0165 0.0781 0.0983
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0144 0.0669 0.0842
Plasmodium falciparum plasmepsin VIII, putative 0.0092 0.0385 0.0484
Echinococcus multilocularis tyrosine protein kinase csk 0.0151 0.0707 0.089
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0144 0.0669 0.0842
Toxoplasma gondii subtilisin SUB1 0.0711 0.3742 0.471
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.0025 0.002 0.0026
Giardia lamblia Translation initiation factor eIF-4A, putative 0.005 0.0157 0.2225
Entamoeba histolytica hypothetical protein 0.0151 0.0707 0.9998
Schistosoma mansoni NADPH flavin oxidoreductase 0.0038 0.0096 0.0103
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0165 0.0781 0.0837
Entamoeba histolytica hypothetical protein 0.0151 0.0707 0.9998
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Entamoeba histolytica type A flavoprotein, putative 0.0029 0.0046 0.0647
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0151 0.0707 0.089
Entamoeba histolytica protein kinase, putative 0.0151 0.0707 0.9998
Onchocerca volvulus 0.0144 0.0669 0.2657
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0121 0.0152
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0076 0.0302 0.038
Schistosoma mansoni maguk P55 subfamily member 26 0.0025 0.002 0.0022
Plasmodium vivax ribonucleotide reductase small subunit, putative 0.0099 0.0424 0.0479
Chlamydia trachomatis transcriptional repressor NrdR 0.0085 0.0351 0.0266
Onchocerca volvulus 0.0151 0.0707 0.2818
Schistosoma mansoni tyrosine kinase 0.0158 0.0746 0.0799
Loa Loa (eye worm) FAD binding domain-containing protein 0.0047 0.0143 0.0143
Schistosoma mansoni hypothetical protein 0.0031 0.0053 0.0057
Giardia lamblia Kinase 0.0151 0.0707 1
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Echinococcus granulosus retinal guanylyl cyclase 2 0.0151 0.0707 0.089
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0292 0.1471 0.1852
Entamoeba histolytica tyrosine kinase, putative 0.0151 0.0707 0.9998
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.005 0.0157 0.2224
Entamoeba histolytica ankyrin repeat protein 0.0151 0.0707 0.9998
Schistosoma mansoni protein kinase 0.0151 0.0707 0.0757
Plasmodium vivax aspartyl protease, putative 0.0092 0.0385 0.0429
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.1486 0.7945 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0151 0.0707 0.9998
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Schistosoma mansoni memapsin-2 (A01 family) 0.1743 0.9335 1
Entamoeba histolytica tyrosine kinase, putative 0.0151 0.0707 0.9998
Entamoeba histolytica type A flavoprotein, putative 0.0029 0.0046 0.0647
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0121 0.0152
Echinococcus granulosus tyrosine protein kinase Src64B 0.0158 0.0746 0.0939
Loa Loa (eye worm) hypothetical protein 0.0464 0.2405 0.2405
Brugia malayi Kelch motif family protein 0.0047 0.014 0.0176
Loa Loa (eye worm) hypothetical protein 0.0151 0.0707 0.0707
Entamoeba histolytica protein kinase, putative 0.0151 0.0707 0.9998
Entamoeba histolytica tyrosin kinase, putative 0.0151 0.0707 0.9998
Onchocerca volvulus 0.0464 0.2405 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0151 0.0707 0.089
Toxoplasma gondii aspartyl protease 0.0092 0.0385 0.0484
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0056 0.0193 0.0207
Echinococcus granulosus neuroendocrine convertase 2 0.005 0.0157 0.0197
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.005 0.0157 0.02
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0056 0.0193 0.0243
Entamoeba histolytica serine/threonine kinase, putative 0.0151 0.0707 0.9998
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0241 0.1194 0.1279
Plasmodium vivax flavodoxin domain containing protein 0.0068 0.0254 0.0264
Schistosoma mansoni integrin alpha 0.121 0.6448 0.6907
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Loa Loa (eye worm) TK/Met protein kinase 0.0151 0.0707 0.0707
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0121 0.0161
Trypanosoma brucei aminopeptidase, putative 0.0056 0.0193 0.0243
Plasmodium falciparum plasmepsin IX 0.0092 0.0385 0.0484
Toxoplasma gondii subtilisin SUB2 0.005 0.0157 0.0197
Trypanosoma cruzi p450 reductase, putative 0.0076 0.0302 0.038
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0121 0.0152
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0151 0.0707 0.9998
Brugia malayi FAD binding domain containing protein 0.0047 0.0143 0.018
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.0025 0.002 0.002
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.005 0.0157 0.0197
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0151 0.0707 0.9998
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.0707 0.0945
Entamoeba histolytica aminopeptidase, putative 0.0144 0.0669 0.9459
Echinococcus granulosus adam 0.0069 0.0259 0.0326
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0025 0.002 0.0026
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0343 0.1748 0.22
Echinococcus granulosus integrin alpha ps 0.026 0.1297 0.1633
Loa Loa (eye worm) TK protein kinase 0.0151 0.0707 0.0707
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0151 0.0707 0.089
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0025 0.002 0.0026
Entamoeba histolytica hypothetical protein 0.0151 0.0707 0.9998
Brugia malayi eukaryotic initiation factor 4A 0.005 0.0157 0.0198
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0047 0.0143 0.0153
Loa Loa (eye worm) hypothetical protein 0.0667 0.3501 0.3501
Schistosoma mansoni site-1 peptidase (S08 family) 0.005 0.0157 0.0168
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Echinococcus multilocularis receptor type guanylyl cyclase 0.0151 0.0707 0.089
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0121 0.0152
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.005 0.0157 0.0198
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.003
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.005 0.0157 0.0049
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0151 0.0707 0.089
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0158 0.0746 0.0939
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Loa Loa (eye worm) TK/FER protein kinase 0.0151 0.0707 0.0707
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0165 0.0781 0.1044
Entamoeba histolytica hypothetical protein 0.0035 0.0076 0.1071
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Brugia malayi SH2 domain containing protein 0.0151 0.0707 0.089
Echinococcus granulosus tyrosine protein kinase Blk 0.0151 0.0707 0.089
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Brugia malayi Pepsin A precursor 0.0092 0.0385 0.0484
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Loa Loa (eye worm) TK protein kinase 0.0151 0.0707 0.0707
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.005 0.0157 0.02
Echinococcus granulosus MAGUK p55 subfamily 0.0025 0.002 0.0026
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0056 0.0193 0.0243
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0151 0.0707 0.0945
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0076 0.0302 0.038
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0151 0.0707 0.089
Brugia malayi intermediate filament protein 0.0028 0.0041 0.0051
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0076 0.0095
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0088 0.0363 0.0457
Echinococcus granulosus leukotriene A 4 hydrolase 0.0056 0.0193 0.0243
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Loa Loa (eye worm) hypothetical protein 0.0151 0.0707 0.0707
Loa Loa (eye worm) TK protein kinase 0.0151 0.0707 0.0707
Schistosoma mansoni maguk P55 subfamily member 35 0.0025 0.002 0.0022
Entamoeba histolytica protein kinase, putative 0.0151 0.0707 0.9998
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0158 0.0746 0.0939
Leishmania major protein kinase, putative 0.0151 0.0707 0.089
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0151 0.0707 0.089
Brugia malayi TATA binding protein associated factor 0.0056 0.0193 0.0243
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.1486 0.7945 1
Echinococcus multilocularis Protein lozenge 0.0058 0.0203 0.0256
Loa Loa (eye worm) TK/ALK protein kinase 0.0151 0.0707 0.0707
Toxoplasma gondii subtilisin SUB9 0.005 0.0157 0.0197
Echinococcus multilocularis disks large 3 0.0072 0.0276 0.0348
Loa Loa (eye worm) hypothetical protein 0.0282 0.1419 0.1419
Brugia malayi bone morphogenetic protein type 1 receptor 0.0151 0.0707 0.089
Entamoeba histolytica protein kinase, putative 0.0151 0.0707 0.9998
Echinococcus multilocularis protein tyrosine kinase 0.0151 0.0707 0.089
Plasmodium falciparum protein kinase, putative 0.0151 0.0707 0.089
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0151 0.0707 0.089
Entamoeba histolytica type A flavoprotein, putative 0.0029 0.0046 0.0647
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0151 0.0707 0.089
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.005 0.0157 0.0168
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0292 0.1471 0.1852
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0092 0.0385 0.0412
Brugia malayi integrin-linked kinase 0.0151 0.0707 0.089
Entamoeba histolytica tyrosine kinase, putative 0.0151 0.0707 0.9998
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.0707 0.0945
Schistosoma mansoni hypothetical protein 0.0055 0.0187 0.02
Treponema pallidum ribonucleotide-diphosphate reductase subunit beta 0.0292 0.1471 0.1804
Plasmodium vivax tyrosine kinase-like protein, putative 0.0151 0.0707 0.0837
Echinococcus multilocularis lamin dm0 0.0028 0.0041 0.0051
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.1486 0.7945 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0056 0.0193 0.0243
Echinococcus granulosus lamin dm0 0.0028 0.0041 0.0051
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Entamoeba histolytica hypothetical protein 0.0151 0.0707 0.9998
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0157 0.0209
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Brugia malayi aspartic protease BmAsp-1, identical 0.0092 0.0385 0.0484
Brugia malayi hypothetical protein 0.0059 0.0206 0.0259
Trichomonas vaginalis protein kinase atn1, putative 0.0151 0.0707 0.0945
Onchocerca volvulus 0.0151 0.0707 0.2818
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Loa Loa (eye worm) hypothetical protein 0.0394 0.2021 0.2021
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0144 0.0669 0.0842
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Giardia lamblia Kinase, NEK 0.0151 0.0707 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0151 0.0707 0.9998
Echinococcus multilocularis transfer RNA-Thr 0.0151 0.0707 0.089
Onchocerca volvulus 0.0151 0.0707 0.2818
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0151 0.0707 0.089
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0693 0.3642 0.4584
Brugia malayi flavodoxin family protein 0.0076 0.0302 0.038
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Loa Loa (eye worm) TK/FER protein kinase 0.0151 0.0707 0.0707
Toxoplasma gondii subtilisin SUB5 0.005 0.0157 0.0197
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0411 0.0517
Echinococcus multilocularis raf serine:threonine protein kinase 0.0151 0.0707 0.089
Entamoeba histolytica protein kinase, putative 0.0151 0.0707 0.9998
Toxoplasma gondii flavodoxin domain-containing protein 0.0038 0.0093 0.0117
Loa Loa (eye worm) TK/INSR protein kinase 0.0151 0.0707 0.0707
Echinococcus multilocularis protein kinase 0.0151 0.0707 0.089
Schistosoma mansoni serine/threonine protein kinase 0.0158 0.0746 0.0799
Trypanosoma brucei protein kinase, putative 0.0151 0.0707 0.089
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Plasmodium vivax subtilisin-like serine protease, putative 0.005 0.0157 0.014
Loa Loa (eye worm) hypothetical protein 0.0151 0.0707 0.0707
Toxoplasma gondii aminopeptidase N protein 0.0343 0.1748 0.22
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0055 0.0187 0.0236
Brugia malayi hypothetical protein 0.0144 0.0669 0.0842
Loa Loa (eye worm) TK/FER protein kinase 0.0151 0.0707 0.0707
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0151 0.0707 0.0757
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0151 0.0707 0.089
Entamoeba histolytica tyrosine kinase, putative 0.0151 0.0707 0.9998
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0144 0.0669 0.0842
Entamoeba histolytica protein kinase, putative 0.0151 0.0707 1
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.005 0.0157 0.02
Brugia malayi Guanylate kinase family protein 0.0025 0.002 0.0026
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0029 0.0046 0.0058
Brugia malayi Receptor family ligand binding region containing protein 0.0151 0.0707 0.089
Schistosoma mansoni protein kinase 0.0151 0.0707 0.0757
Entamoeba histolytica serine/threonine kinase, putative 0.0151 0.0707 0.9998
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0292 0.1471 0.1852
Echinococcus multilocularis GPCR, family 2 0.0031 0.0053 0.0067
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0029 0.0046 0.0061
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Echinococcus multilocularis membrane bound transcription factor site 1 0.005 0.0157 0.0197
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Plasmodium falciparum plasmepsin VII 0.0092 0.0385 0.0484
Brugia malayi Peptidase family M1 containing protein 0.0387 0.1987 0.2501
Entamoeba histolytica tyrosine kinase, putative 0.0151 0.0707 0.9998
Echinococcus multilocularis integrin alpha ps 0.0543 0.2828 0.356
Brugia malayi Furin-like cysteine rich region family protein 0.0151 0.0707 0.089
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0151 0.0707 0.9998
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Echinococcus multilocularis tyrosine protein kinase HCK 0.0151 0.0707 0.089
Trichomonas vaginalis CAMK family protein kinase 0.0151 0.0707 0.0945
Echinococcus granulosus activated cdc42 kinase 1 0.0151 0.0707 0.089
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.005 0.0157 0.0168
Mycobacterium ulcerans transcriptional regulator NrdR 0.0085 0.0351 0.0312
Echinococcus granulosus MAGUK p55 subfamily 0.0025 0.002 0.0026
Brugia malayi Integrin alpha pat-2 precursor 0.121 0.6448 0.8115
Loa Loa (eye worm) hypothetical protein 0.0151 0.0707 0.0707
Entamoeba histolytica hypothetical protein 0.0151 0.0707 0.9998
Plasmodium vivax aspartyl proteinase, putative 0.0092 0.0385 0.0429
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0151 0.0707 0.2818
Echinococcus multilocularis tyrosine protein kinase shark 0.0151 0.0707 0.089
Echinococcus granulosus transcription factor Dp 1 0.004 0.0105 0.0132
Loa Loa (eye worm) hypothetical protein 0.0151 0.0707 0.0707
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.1401 0.7482 1
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Brugia malayi Guanylyl cyclase protein 23 0.0151 0.0707 0.089
Loa Loa (eye worm) hypothetical protein 0.095 0.5038 0.5038
Brugia malayi hypothetical protein 0.0035 0.0076 0.0095
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0151 0.0707 0.0707
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.1486 0.7945 0.7945
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.005 0.0157 0.0197
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0056 0.0193 0.0243
Onchocerca volvulus 0.0151 0.0707 0.2818
Onchocerca volvulus 0.0151 0.0707 0.2818
Entamoeba histolytica tyrosine kinase, putative 0.0151 0.0707 0.9998
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.0707 0.0757
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0053 0.0067
Onchocerca volvulus 0.0151 0.0707 0.2818
Brugia malayi Eukaryotic aspartyl protease family protein 0.0092 0.0385 0.0484
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0056 0.0193 0.0243
Leishmania major eukaryotic initiation factor 4a, putative 0.005 0.0157 0.0198
Loa Loa (eye worm) integrin beta-2 0.0307 0.155 0.155
Echinococcus multilocularis integrin beta 2 0.0227 0.1119 0.1409
Loa Loa (eye worm) hypothetical protein 0.0047 0.014 0.014
Entamoeba histolytica hypothetical protein 0.0035 0.0076 0.1071
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0158 0.0746 0.0939
Chlamydia trachomatis cytosol aminopeptidase 0.0115 0.0511 0.0471
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0092 0.0385 0.0412
Echinococcus granulosus MAGUK p55 subfamily 0.0025 0.002 0.0026
Toxoplasma gondii subtilisin SUB12 0.005 0.0157 0.0197
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Entamoeba histolytica hypothetical protein 0.0151 0.0707 0.9998
Plasmodium falciparum plasmepsin III 0.0092 0.0385 0.0484
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0045 0.0131 0.0164
Schistosoma mansoni protein kinase 0.0151 0.0707 0.0757
Echinococcus granulosus tyrosine kinase 0.0151 0.0707 0.089
Plasmodium falciparum plasmepsin II 0.0165 0.0781 0.0983
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0151 0.0707 0.9998
Brugia malayi Reprolysin 0.0026 0.003 0.0037
Loa Loa (eye worm) hypothetical protein 0.0092 0.0385 0.0385
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0263 0.0331
Toxoplasma gondii STE kinase 0.0151 0.0707 0.089
Leishmania major cytochrome P450 reductase, putative 0.0068 0.0254 0.032
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0151 0.0707 0.089
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0292 0.1471 0.1852
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0151 0.0707 0.089
Brugia malayi FAD binding domain containing protein 0.0076 0.0302 0.038
Schistosoma mansoni site-1 peptidase (S08 family) 0.005 0.0157 0.0168
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0025 0.002 0.0022
Echinococcus granulosus integrin alpha ps 0.0543 0.2828 0.356
Echinococcus granulosus tyrosine protein kinase HCK 0.0151 0.0707 0.089
Echinococcus granulosus eukaryotic initiation factor 4A III 0.005 0.0157 0.0198
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0121 0.0152
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Echinococcus granulosus disks large 3 0.0072 0.0276 0.0348
Brugia malayi ribonucleotide reductase 2 0.0292 0.1471 0.1852
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.005 0.0157 0.0049
Plasmodium falciparum eukaryotic initiation factor 4A 0.005 0.0157 0.0198
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0056 0.0193 0.0259
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Echinococcus granulosus activated cdc42 kinase 1 0.0151 0.0707 0.089
Schistosoma mansoni hypothetical protein 0.0055 0.0187 0.02
Loa Loa (eye worm) TK/ACK protein kinase 0.0151 0.0707 0.0707
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0151 0.0707 0.089
Entamoeba histolytica receptor protein kinase, putative 0.0151 0.0707 0.9998
Echinococcus multilocularis integrin alpha ps 0.0543 0.2828 0.356
Entamoeba histolytica tyrosin kinase, putative 0.0151 0.0707 0.9998
Echinococcus multilocularis epidermal growth factor receptor 0.0151 0.0707 0.089
Echinococcus granulosus tyrosine protein kinase Srms 0.0151 0.0707 0.089
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0151 0.0707 0.9998
Loa Loa (eye worm) TK protein kinase 0.0151 0.0707 0.0707
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Loa Loa (eye worm) TK/FER protein kinase 0.0151 0.0707 0.0707
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.005 0.0157 0.0198
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0151 0.0707 0.9998
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0121 0.0152
Echinococcus multilocularis 0.0025 0.002 0.0026
Echinococcus granulosus kelch ECH associated protein 1 like 0.0093 0.0392 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.0707 0.0945
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.1401 0.7482 1
Echinococcus granulosus activin receptor type 0.0151 0.0707 0.089
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0076 0.0302 0.0246
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Schistosoma mansoni lamin 0.0028 0.0041 0.0044
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0667 0.3501 0.3501
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0105 0.0132
Loa Loa (eye worm) hypothetical protein 0.0151 0.0707 0.0707
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Brugia malayi Guanylate kinase family protein 0.0079 0.0315 0.0397
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0292 0.1471 0.1852
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Echinococcus multilocularis kelch ECH associated protein 1 0.0093 0.0392 0.0494
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0029 0.0046 0.0058
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0151 0.0707 0.089
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0151 0.0707 0.089
Echinococcus granulosus Furin 1 0.005 0.0157 0.0197
Toxoplasma gondii subtilisin SUB8 0.005 0.0157 0.0197
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0047 0.014 0.014
Schistosoma mansoni protein kinase 0.0151 0.0707 0.0757
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0151 0.0707 0.089
Brugia malayi protein-tyrosine kinase 0.0151 0.0707 0.089
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0165 0.0781 0.0983
Loa Loa (eye worm) apoptosis regulator protein 0.0055 0.0187 0.0187
Brugia malayi hypothetical protein 0.0151 0.0707 0.089
Echinococcus granulosus lamin 0.0028 0.0041 0.0051
Schistosoma mansoni hypothetical protein 0.0031 0.0053 0.0057
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0151 0.0707 0.9998
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0158 0.0746 0.0939
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0121 0.0152
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0151 0.0707 0.9998
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0151 0.0707 0.089
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Loa Loa (eye worm) TK/FER protein kinase 0.0151 0.0707 0.0707
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0151 0.0707 0.0945
Echinococcus multilocularis integrin alpha ps 0.026 0.1297 0.1633
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0121 0.0152
Echinococcus multilocularis integrin alpha 3 0.0928 0.4916 0.6188
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0158 0.0746 0.0939
Loa Loa (eye worm) TK/EPH protein kinase 0.0151 0.0707 0.0707
Echinococcus granulosus integrin alpha 3 0.0928 0.4916 0.6188
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0158 0.0746 0.0939
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0151 0.0707 0.0945
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Schistosoma mansoni cathepsin D (A01 family) 0.0352 0.1793 0.192
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0055 0.0187 0.0236
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0041 0.0041
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0158 0.0746 0.0939
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0292 0.1471 0.1852
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Echinococcus granulosus tyrosine protein kinase csk 0.0151 0.0707 0.089
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Echinococcus granulosus integrin beta 2 0.0227 0.1119 0.1409
Trypanosoma cruzi protein kinase, putative 0.0151 0.0707 0.089
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0328 0.1664 0.2094
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0068 0.0257 0.0323
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0292 0.1471 0.1576
Brugia malayi Immunoglobulin I-set domain containing protein 0.0151 0.0707 0.089
Echinococcus granulosus tyrosine protein kinase csk 0.0151 0.0707 0.089
Schistosoma mansoni cathepsin D (A01 family) 0.0352 0.1793 0.192
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0068 0.0254 0.034
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0056 0.0193 0.0207
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Onchocerca volvulus 0.0151 0.0707 0.2818
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0076 0.0081
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0076 0.0302 0.0302
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Loa Loa (eye worm) hypothetical protein 0.0151 0.0707 0.0707
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0076 0.0302 0.038
Plasmodium vivax tyrosine kinase-like protein, putative 0.0151 0.0707 0.0837
Echinococcus granulosus protein kinase 0.0151 0.0707 0.089
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0151 0.0707 0.089
Trichomonas vaginalis AGC family protein kinase 0.0151 0.0707 0.0945
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Brugia malayi Raf kinase 0.0151 0.0707 0.089
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.005 0.0157 0.021
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0076 0.0302 0.0324
Brugia malayi polk-prov protein 0.0033 0.0064 0.0081
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0693 0.3642 0.4584
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0029 0.0046 0.0061
Echinococcus granulosus natriuretic peptide receptor 1 0.0151 0.0707 0.089
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0092 0.0385 0.0412
Toxoplasma gondii protein kinase domain-containing protein 0.0151 0.0707 0.089
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Loa Loa (eye worm) serine/threonine protein kinase 0.0151 0.0707 0.0707
Onchocerca volvulus 0.0151 0.0707 0.2818
Schistosoma mansoni serine/threonine RGC 0.0151 0.0707 0.0757
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Entamoeba histolytica serine/threonine kinase, putative 0.0151 0.0707 0.9998
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0151 0.0707 0.9998
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0151 0.0707 0.089
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0504 0.2618 0.3493
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Schistosoma mansoni hypothetical protein 0.0055 0.0187 0.02
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0263 0.0331
Echinococcus granulosus tyrosine protein kinase Fyn 0.0158 0.0746 0.0939
Loa Loa (eye worm) TK/RYK protein kinase 0.0151 0.0707 0.0707
Echinococcus multilocularis integrin linked protein kinase 0.0151 0.0707 0.089
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0151 0.0707 0.9998
Echinococcus multilocularis c src tyrosine kinase 0.0158 0.0746 0.0939
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit beta 0.0292 0.1471 0.1702
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1325 0.7072 0.7575
Entamoeba histolytica protein kinase, putative 0.0151 0.0707 0.9998
Echinococcus multilocularis eukaryotic initiation factor 4A 0.005 0.0157 0.0198
Loa Loa (eye worm) hypothetical protein 0.0132 0.0604 0.0604
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0151 0.0707 0.0757
Brugia malayi SRC-1 0.0158 0.0746 0.0939
Onchocerca volvulus Tyrosine kinase homolog 0.0151 0.0707 0.2818
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0151 0.0707 0.0757
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Schistosoma mansoni protein kinase 0.0151 0.0707 0.0757
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Entamoeba histolytica ankyrin repeat protein 0.0151 0.0707 0.9998
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0394 0.2021 0.2544
Plasmodium vivax plasmepsin IV, putative 0.0165 0.0781 0.0931
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0144 0.0669 0.0894
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0151 0.0707 0.089
Loa Loa (eye worm) reprolysin 0.0045 0.0131 0.0131
Loa Loa (eye worm) peptidase family M1 containing protein 0.03 0.1512 0.1512
Loa Loa (eye worm) hypothetical protein 0.005 0.0157 0.0157
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0151 0.0707 0.089
Entamoeba histolytica tyrosin kinase, putative 0.0151 0.0707 0.9998
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0092 0.0385 0.0412
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0088 0.0363 0.0457
Trichomonas vaginalis sulfite reductase, putative 0.0076 0.0302 0.0403
Leishmania major hypothetical protein, conserved 0.0029 0.0046 0.0058
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.005 0.0157 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0121 0.0152
Schistosoma mansoni integrin alpha-ps 0.0282 0.1419 0.152
Loa Loa (eye worm) runx1 0.0058 0.0203 0.0203
Brugia malayi proprotein convertase 2 0.005 0.0157 0.0197
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0029 0.0046 0.0058
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0151 0.0707 0.9998
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.1401 0.7482 1
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.005 0.0157 0.0197
Echinococcus multilocularis lamin 0.0028 0.0041 0.0051
Toxoplasma gondii aminopeptidase N, putative 0.0343 0.1748 0.22
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0092 0.0385 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0157 0.0209
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.005 0.0157 0.0198
Entamoeba histolytica protein kinase, putative 0.0151 0.0707 0.9998
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0076 0.0095
Echinococcus granulosus ephrin type A receptor 4 A 0.0151 0.0707 0.089
Echinococcus granulosus membrane bound transcription factor site 1 0.005 0.0157 0.0197
Loa Loa (eye worm) TK/FER protein kinase 0.0151 0.0707 0.0707
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0025 0.002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0053
Giardia lamblia DINP protein human, muc B family 0.0022 0.0007 0.0101
Onchocerca volvulus 0.0056 0.0193 0.0646
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.1486 0.7945 1
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0292 0.1471 0.1852
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Loa Loa (eye worm) hypothetical protein 0.0331 0.1681 0.1681
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0158 0.0746 0.0939
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Plasmodium vivax aspartyl proteinase, putative 0.0165 0.0781 0.0931
Entamoeba histolytica hypothetical protein 0.0035 0.0076 0.1071
Entamoeba histolytica tyrosine kinase, putative 0.0151 0.0707 0.9998
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0144 0.0669 0.0842
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0151 0.0707 0.9998
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.005 0.0157 0.0197
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0151 0.0707 0.089
Schistosoma mansoni cell polarity protein 0.0072 0.0276 0.0296
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.005 0.0157 0.0168
Plasmodium vivax aspartyl protease, putative 0.0092 0.0385 0.0429
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0151 0.0707 0.089
Echinococcus granulosus epidermal growth factor receptor 0.0151 0.0707 0.089
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0245 0.0309
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0158 0.0746 0.0939
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0411 0.0411
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Echinococcus granulosus fibroblast growth factor receptor 4 0.0151 0.0707 0.089
Loa Loa (eye worm) hypothetical protein 0.0066 0.0245 0.0245
Loa Loa (eye worm) TK/FAK protein kinase 0.0151 0.0707 0.0707
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0151 0.0707 0.089
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0292 0.1471 0.1852
Loa Loa (eye worm) TK protein kinase 0.0151 0.0707 0.0707
Echinococcus multilocularis kinase suppressor of Ras 1 0.0151 0.0707 0.089
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0121 0.0152
Loa Loa (eye worm) RGC/RGC protein kinase 0.0151 0.0707 0.0707
Echinococcus granulosus tyrosine kinase 0.0151 0.0707 0.089
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0076 0.0302 0.038
Brugia malayi hypothetical protein 0.0056 0.0193 0.0243
Loa Loa (eye worm) TK/FER protein kinase 0.0151 0.0707 0.0707
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0144 0.0669 0.0842
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0151 0.0707 0.089
Plasmodium falciparum nitric oxide synthase, putative 0.0076 0.0302 0.038
Echinococcus granulosus kinase suppressor of Ras 1 0.0151 0.0707 0.089
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0056 0.0193 0.0243
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.005 0.0157 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.0707 0.0945
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.1486 0.7945 1
Leishmania major eukaryotic initiation factor 4a, putative 0.005 0.0157 0.0198
Entamoeba histolytica protein kinase, putative 0.0151 0.0707 0.9998
Entamoeba histolytica protein kinase, putative 0.0151 0.0707 0.9998
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Loa Loa (eye worm) TK/FER protein kinase 0.0151 0.0707 0.0707
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0151 0.0707 0.9998
Entamoeba histolytica protein kinase, putative 0.0151 0.0707 0.9998
Echinococcus granulosus leucine aminopeptidase protein 0.0115 0.0511 0.0643
Leishmania major subtilisin-like serine peptidase 0.005 0.0157 0.0197
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.005 0.0157 0.0197
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0151 0.0707 0.089
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Echinococcus granulosus insulin receptor 0.0151 0.0707 0.089
Echinococcus granulosus raf serine:threonine protein kinase 0.0151 0.0707 0.089
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0056 0.0193 0.0243
Schistosoma mansoni hypothetical protein 0.026 0.1297 0.1389
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.1486 0.7945 1
Trypanosoma brucei Aminopeptidase M1, putative 0.0144 0.0669 0.0842
Loa Loa (eye worm) hypothetical protein 0.0056 0.0193 0.0193
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0045 0.0131 0.0164
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0076 0.0302 0.038
Echinococcus granulosus integrin linked protein kinase 0.0151 0.0707 0.089
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0158 0.0746 0.0939
Echinococcus granulosus protein tyrosine kinase 0.0151 0.0707 0.089
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.043 0.2217 0.2791
Plasmodium falciparum plasmepsin X 0.0092 0.0385 0.0484
Leishmania major p450 reductase, putative 0.0076 0.0302 0.038
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0151 0.0707 0.089
Brugia malayi ephrin receptor 1 precursor 0.0151 0.0707 0.089
Echinococcus multilocularis activin receptor type 0.0151 0.0707 0.089
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Loa Loa (eye worm) hypothetical protein 0.0667 0.3501 0.3501
Onchocerca volvulus 0.005 0.0157 0.049
Plasmodium falciparum subtilisin-like protease 1 0.0711 0.3742 0.471
Loa Loa (eye worm) TK protein kinase 0.0151 0.0707 0.0707
Echinococcus granulosus epidermal growth factor receptor 0.0151 0.0707 0.089
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0292 0.1471 0.1959
Schistosoma mansoni ATP-dependent RNA Helicase 0.0025 0.002 0.0022
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Brugia malayi endoprotease bli-4 precursor 0.005 0.0157 0.0197
Mycobacterium leprae conserved hypothetical protein 0.0085 0.0351 0.0265
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Entamoeba histolytica tyrosine kinase, putative 0.0151 0.0707 0.9998
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0068 0.0257 0.0323
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.0707 0.0757
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.005 0.0157 0.021
Loa Loa (eye worm) hypothetical protein 0.0151 0.0707 0.0707
Echinococcus granulosus kelch ECH associated protein 1 like 0.0093 0.0392 0.0494
Brugia malayi neuroendocrine convertase 1 precursor 0.005 0.0157 0.0197
Echinococcus multilocularis tyrosine kinase 0.0151 0.0707 0.089
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0076 0.0302 0.038
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0151 0.0707 0.0707
Loa Loa (eye worm) hypothetical protein 0.0151 0.0707 0.0707
Schistosoma mansoni diflavin oxidoreductase 0.0038 0.0093 0.0099
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0053 0.0067
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit beta 0.0099 0.0424 0.0412
Schistosoma mansoni tyrosine kinase 0.0158 0.0746 0.0799
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.1486 0.7945 0.8511
Schistosoma mansoni lozenge 0.0058 0.0203 0.0218
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.0025 0.002 0.0026
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Loa Loa (eye worm) hypothetical protein 0.0668 0.3507 0.3507
Loa Loa (eye worm) protein kinase domain-containing protein 0.0151 0.0707 0.0707
Loa Loa (eye worm) hypothetical protein 0.0151 0.0707 0.0707
Schistosoma mansoni protein kinase 0.0151 0.0707 0.0757
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0157 0.0209
Entamoeba histolytica protein kinase, putative 0.0151 0.0707 0.9998
Plasmodium falciparum M17 leucyl aminopeptidase 0.0068 0.0257 0.0323
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0121 0.0152
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Trichomonas vaginalis protein tyrosine kinase, putative 0.0151 0.0707 0.0945
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0144 0.0669 0.0842
Trichomonas vaginalis TK family protein kinase 0.0151 0.0707 0.0945
Loa Loa (eye worm) SRC-1 0.0158 0.0746 0.0746
Echinococcus multilocularis tyrosine protein kinase Abl 0.0158 0.0746 0.0939
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0151 0.0707 0.089
Loa Loa (eye worm) hypothetical protein 0.0145 0.0673 0.0673
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0158 0.0746 0.0939
Loa Loa (eye worm) TK/ABL protein kinase 0.0151 0.0707 0.0707
Toxoplasma gondii subtilisin SUB10 0.005 0.0157 0.0197
Brugia malayi Immunoglobulin I-set domain containing protein 0.0151 0.0707 0.089
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0151 0.0707 0.0707
Entamoeba histolytica hypothetical protein 0.0151 0.0707 0.9998
Schistosoma mansoni integrin beta subunit 0.0181 0.0867 0.0928
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Echinococcus multilocularis methionine synthase reductase 0.0047 0.0143 0.018
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0029 0.0046 0.0058
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0292 0.1471 0.1852
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0144 0.0669 0.0716
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0151 0.0707 0.089
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.0707 0.0945
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0263 0.0331
Loa Loa (eye worm) hypothetical protein 0.0915 0.485 0.485
Echinococcus granulosus receptor type guanylyl cyclase 0.0151 0.0707 0.089
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Toxoplasma gondii protein kinase 0.0151 0.0707 0.089
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.005 0.0157 0.0197
Loa Loa (eye worm) TK/FER protein kinase 0.0151 0.0707 0.0707
Leishmania major DNA polymerase kappa, putative 0.0022 0.0007 0.0009
Trypanosoma cruzi protein kinase, putative 0.0151 0.0707 0.089
Leishmania major hypothetical protein, conserved 0.0151 0.0707 0.089
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.0707 0.0945
Loa Loa (eye worm) proprotein convertase 2 0.005 0.0157 0.0157
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0092 0.0385 0.0385
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0088 0.0363 0.0389
Echinococcus granulosus tyrosine protein kinase Lyn 0.0158 0.0746 0.0939
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0121 0.0152
Schistosoma mansoni protein kinase 0.0151 0.0707 0.0757
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.005 0.0157 0.0049
Echinococcus multilocularis tyrosine kinase 0.0151 0.0707 0.089
Plasmodium vivax RNA helicase-1, putative 0.005 0.0157 0.0141
Onchocerca volvulus 0.0387 0.1987 0.8231
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0076 0.0302 0.038
Loa Loa (eye worm) TK/EGFR protein kinase 0.0151 0.0707 0.0707
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.002
Brugia malayi hypothetical protein 0.0151 0.0707 0.089
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Loa Loa (eye worm) TK protein kinase 0.0151 0.0707 0.0707
Brugia malayi C-terminal src kinase protein 1 0.0151 0.0707 0.089
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0151 0.0707 0.089
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0064 0.0081
Loa Loa (eye worm) FAD binding domain-containing protein 0.0076 0.0302 0.0302
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0041 0.0051
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Schistosoma mansoni aminopeptidase A (M01 family) 0.0056 0.0193 0.0207
Onchocerca volvulus 0.0151 0.0707 0.2818
Giardia lamblia Nitric oxide synthase, inducible 0.0068 0.0254 0.3599
Entamoeba histolytica tyrosine kinase, putative 0.0151 0.0707 0.9998
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0151 0.0707 0.089
Loa Loa (eye worm) hypothetical protein 0.0151 0.0707 0.0707
Brugia malayi hypothetical protein 0.0151 0.0707 0.089
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0151 0.0707 0.9998
Loa Loa (eye worm) flavodoxin family protein 0.0029 0.0046 0.0046
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0915 0.485 0.6104
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0092 0.0385 0.0412
Plasmodium vivax subtilisin-like protease 2, putative 0.005 0.0157 0.014
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0144 0.0669 0.0842
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0055 0.0187 0.02
Loa Loa (eye worm) TK/FER protein kinase 0.0151 0.0707 0.0707
Entamoeba histolytica protein kinase, putative 0.0151 0.0707 0.9998
Brugia malayi Subtilase family protein 0.005 0.0157 0.0197
Giardia lamblia Protein 21.1 0.0151 0.0707 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0151 0.0707 0.089
Echinococcus multilocularis musashi 0.0028 0.0041 0.0051
Entamoeba histolytica serine/threonine kinase, putative 0.0151 0.0707 0.9998
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Entamoeba histolytica serine/threonine kinase, putative 0.0151 0.0707 0.9998
Loa Loa (eye worm) RGC/RGC protein kinase 0.0151 0.0707 0.0707
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0328 0.1664 0.2094
Entamoeba histolytica hypothetical protein, conserved 0.0151 0.0707 0.9998
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Schistosoma mansoni protein kinase 0.0151 0.0707 0.0757
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0115 0.0511 0.0589
Echinococcus multilocularis MAGUK p55 subfamily 0.0025 0.002 0.0026
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.005 0.0157 0.0197
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.005 0.0157 0.0168
Onchocerca volvulus 0.0151 0.0707 0.2818
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0068 0.0257 0.0323
Echinococcus granulosus tyrosine protein kinase ABL1 0.0151 0.0707 0.089
Schistosoma mansoni protein kinase 0.0151 0.0707 0.0757
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Brugia malayi ADAM-TS Spacer 1 family protein 0.0026 0.003 0.0037
Loa Loa (eye worm) TATA binding protein associated factor 0.0056 0.0193 0.0193
Entamoeba histolytica hypothetical protein 0.0151 0.0707 0.9998
Trypanosoma brucei subtilisin peptidase 0.005 0.0157 0.0197
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0144 0.0669 0.0894
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Entamoeba histolytica type A flavoprotein, putative 0.0029 0.0046 0.0647
Echinococcus granulosus tyrosine protein kinase Fyn 0.0158 0.0746 0.0939
Echinococcus multilocularis tyrosine protein kinase csk 0.0151 0.0707 0.089
Echinococcus multilocularis tyrosine protein kinase Blk 0.0151 0.0707 0.089
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0076 0.0302 0.038
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0263 0.0331
Echinococcus granulosus intermediate filament protein 0.0028 0.0041 0.0051
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0076 0.0302 0.038
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0092 0.0385 0.0412
Mycobacterium ulcerans aminopeptidase N PepN 0.0144 0.0669 0.0745
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Onchocerca volvulus 0.0032 0.0059 0.0079
Trypanosoma cruzi aminopeptidase, putative 0.0056 0.0193 0.0243
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0151 0.0707 0.0757
Plasmodium falciparum protein kinase, putative 0.0151 0.0707 0.089
Loa Loa (eye worm) TK/FER protein kinase 0.0151 0.0707 0.0707
Echinococcus multilocularis tyrosine protein kinase 0.0151 0.0707 0.089
Entamoeba histolytica hypothetical protein 0.0151 0.0707 0.9998
Brugia malayi SH2 domain containing protein 0.0151 0.0707 0.089
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0151 0.0707 0.089
Loa Loa (eye worm) hypothetical protein 0.026 0.1297 0.1297
Echinococcus multilocularis neuroendocrine convertase 2 0.005 0.0157 0.0197
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0151 0.0707 0.0757
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0144 0.0669 0.0842
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0151 0.0707 0.089
Schistosoma mansoni MAGUK homolog 0.0025 0.002 0.0022
Plasmodium falciparum tyrosine kinase-like protein 0.0151 0.0707 0.089
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Echinococcus granulosus aminopeptidase N 0.0387 0.1987 0.2501
Loa Loa (eye worm) TK/FER protein kinase 0.0151 0.0707 0.0707
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Echinococcus multilocularis MAGUK p55 subfamily 0.0025 0.002 0.0026
Brugia malayi Peptidase family M1 containing protein 0.0144 0.0669 0.0842
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0144 0.0669 0.0842
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.005 0.0157 0.0168
Echinococcus multilocularis aminopeptidase N 0.0387 0.1987 0.2501
Echinococcus granulosus tyrosine protein kinase shark 0.0151 0.0707 0.089
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0066 0.0248 0.0248
Brugia malayi celfurPC protein 0.005 0.0157 0.0197
Toxoplasma gondii subtilisin SUB6 0.005 0.0157 0.0197
Entamoeba histolytica protein kinase, putative 0.0151 0.0707 1
Echinococcus multilocularis FL cytokine receptor 0.0151 0.0707 0.089
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Toxoplasma gondii subtilisin SUB4 0.005 0.0157 0.0197
Trypanosoma cruzi subtilisin peptidase 0.005 0.0157 0.0197
Plasmodium falciparum protein kinase, putative 0.0151 0.0707 0.089
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0165 0.0781 0.0781
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.005 0.0157 0.0198
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0151 0.0707 0.089
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.0707 0.0757
Plasmodium vivax subtilisin-like protease 1 0.0711 0.3742 0.468
Loa Loa (eye worm) TK protein kinase 0.0151 0.0707 0.0707
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Trypanosoma brucei Pseudokinase, putative 0.0151 0.0707 0.089
Entamoeba histolytica tyrosine kinase, putative 0.0151 0.0707 0.9998
Echinococcus multilocularis tyrosine protein kinase csk 0.0151 0.0707 0.089
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0056 0.0193 0.0243
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.0085 0.0351 0.046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Echinococcus multilocularis activated cdc42 kinase 1 0.0151 0.0707 0.089
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0151 0.0707 0.089
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0151 0.0707 0.089
Schistosoma mansoni apoptosis regulator bax 0.0055 0.0187 0.02
Echinococcus granulosus tyrosine kinase 0.0151 0.0707 0.089
Loa Loa (eye worm) TK/ROR protein kinase 0.0151 0.0707 0.0707
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0068 0.0257 0.0323
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0056 0.0193 0.0193
Trypanosoma brucei Flagellum attachment zone protein 20 0.0151 0.0707 0.089
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0157 0.0209
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0151 0.0707 0.0707
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0121 0.0152
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0076 0.0302 0.038
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0151 0.0707 0.0757
Entamoeba histolytica protein kinase, putative 0.0151 0.0707 0.9998
Plasmodium vivax protein kinase, putative 0.0151 0.0707 0.0837
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0029 0.0046 0.0061
Giardia lamblia Kinase, NEK 0.0151 0.0707 1
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0099 0.0424 0.0534
Treponema pallidum ATP-dependent RNA helicase 0.005 0.0157 0.0141
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0144 0.0669 0.0842
Loa Loa (eye worm) TK/CSK protein kinase 0.0151 0.0707 0.0707
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0099 0.0424 0.0534
Echinococcus granulosus kelch ECH associated protein 1 0.0093 0.0392 0.0494
Brugia malayi hypothetical protein 0.0047 0.014 0.0176
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0292 0.1471 0.1852
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Schistosoma mansoni protein kinase 0.0151 0.0707 0.0757
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Loa Loa (eye worm) TK/FER protein kinase 0.0151 0.0707 0.0707
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0151 0.0707 0.0707
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0092 0.0385 0.0484
Plasmodium vivax plasmepsin V, putative 0.0092 0.0385 0.0429
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.0064
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0083 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0064 0.0081
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Entamoeba histolytica hypothetical protein 0.0151 0.0707 0.9998
Schistosoma mansoni hypothetical protein 0.0093 0.0394 0.0422
Onchocerca volvulus 0.0092 0.0385 0.1455
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.1401 0.7482 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0193 0.0193
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0151 0.0707 0.089
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.005 0.0157 0.0198
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Echinococcus granulosus eukaryotic initiation factor 4A 0.005 0.0157 0.0198
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0144 0.0669 0.0842
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0144 0.0669 0.0842
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Schistosoma mansoni hypothetical protein 0.0031 0.0053 0.0057
Loa Loa (eye worm) hypothetical protein 0.0464 0.2405 0.2405
Plasmodium falciparum plasmepsin V 0.0092 0.0385 0.0484
Echinococcus granulosus GPCR family 2 0.0031 0.0053 0.0067
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0055 0.0187 0.0236
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0029 0.0046 0.0058
Echinococcus multilocularis adam 0.0069 0.0259 0.0326
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0093 0.039 0.0418
Schistosoma mansoni intermediate filament proteins 0.0028 0.0041 0.0044
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.005 0.0157 0.021
Echinococcus multilocularis protein KINase family member (kin 25) 0.0151 0.0707 0.089
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Onchocerca volvulus 0.0092 0.0385 0.1455
Loa Loa (eye worm) hypothetical protein 0.0056 0.0193 0.0193
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0263 0.0331
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0151 0.0707 0.089
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.1486 0.7945 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Entamoeba histolytica tyrosine kinase, putative 0.0151 0.0707 0.9998
Entamoeba histolytica hypothetical protein 0.0035 0.0076 0.1071
Entamoeba histolytica receptor protein kinase, putative 0.0151 0.0707 0.9998
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0263 0.0281
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0165 0.0781 0.0983
Echinococcus multilocularis 0.005 0.0157 0.0197
Toxoplasma gondii aspartyl protease ASP1 0.0165 0.0781 0.0983
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0056 0.0193 0.0243
Brugia malayi Peptidase family M1 containing protein 0.0056 0.0193 0.0243
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Schistosoma mansoni ephrin receptor 0.0151 0.0707 0.0757
Echinococcus granulosus tyrosine protein kinase Src42A 0.0158 0.0746 0.0939
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0151 0.0707 0.089
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Echinococcus granulosus tyrosine protein kinase 0.0151 0.0707 0.089
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.005 0.0157 0.0201
Loa Loa (eye worm) hypothetical protein 0.0055 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0088 0.0363 0.0363
Entamoeba histolytica protein kinase, putative 0.0151 0.0707 0.9998
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0292 0.1471 0.1471
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.0707 0.0945
Echinococcus granulosus c src tyrosine kinase 0.0158 0.0746 0.0939
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Loa Loa (eye worm) hypothetical protein 0.0028 0.0041 0.0041
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Echinococcus granulosus methionine synthase reductase 0.0047 0.0143 0.018
Trichomonas vaginalis TKL family protein kinase 0.0151 0.0707 0.0945
Entamoeba histolytica type A flavoprotein, putative 0.0029 0.0046 0.0647
Echinococcus multilocularis protein kinase 0.0151 0.0707 0.089
Trypanosoma brucei unspecified product 0.0036 0.0083 0.0105
Brugia malayi Tyrosine-protein kinase PR2 0.0151 0.0707 0.089
Echinococcus multilocularis Kelch repeat type 1 0.0093 0.0394 0.0496
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0151 0.0707 0.2818
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.005 0.0157 0.0168
Echinococcus multilocularis MAGUK p55 subfamily 0.0025 0.002 0.0026
Onchocerca volvulus 0.0151 0.0707 0.2818
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0151 0.0707 0.089
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Schistosoma mansoni tyrosine protein kinase 0.0151 0.0707 0.0757
Loa Loa (eye worm) hypothetical protein 0.0243 0.1206 0.1206
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0157 0.0209
Trichomonas vaginalis STE family protein kinase 0.0151 0.0707 0.0945
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0343 0.1748 0.2155
Brugia malayi Protein kinase domain containing protein 0.0151 0.0707 0.089
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0263 0.0331
Loa Loa (eye worm) TK protein kinase 0.0151 0.0707 0.0707
Entamoeba histolytica protein kinase, putative 0.0151 0.0707 0.9998
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0158 0.0746 0.0939
Echinococcus multilocularis epidermal growth factor receptor 0.0151 0.0707 0.089
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.1486 0.7945 1
Plasmodium falciparum plasmepsin I 0.0165 0.0781 0.0983
Loa Loa (eye worm) TK protein kinase 0.0151 0.0707 0.0707
Schistosoma mansoni tyrosine kinase 0.0158 0.0746 0.0799
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0053 0.0067
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0076 0.0302 0.038
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0056 0.0193 0.0187
Schistosoma mansoni cytochrome P450 reductase 0.0076 0.0302 0.0323
Entamoeba histolytica tyrosine kinase, putative 0.0151 0.0707 0.9998
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0053 0.0053
Mycobacterium ulcerans leucyl aminopeptidase 0.0115 0.0511 0.053
Schistosoma mansoni tyrosine kinase 0.0151 0.0707 0.0757
Trypanosoma brucei Aminopeptidase M1, putative 0.0144 0.0669 0.0842
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0131 0.014
Loa Loa (eye worm) TK/FER protein kinase 0.0151 0.0707 0.0707
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.1486 0.7945 1
Entamoeba histolytica protein kinase, putative 0.0151 0.0707 0.9998
Schistosoma mansoni hypothetical protein 0.0031 0.0053 0.0057
Loa Loa (eye worm) RGC/RGC protein kinase 0.0151 0.0707 0.0707
Schistosoma mansoni hypothetical protein 0.0151 0.0707 0.0757
Loa Loa (eye worm) hypothetical protein 0.005 0.0157 0.0157
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0151 0.0707 0.9998
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0707 0.9998
Toxoplasma gondii subtilisin SUB7 0.005 0.0157 0.0197
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0151 0.0707 0.089
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0121 0.0152
Onchocerca volvulus 0.0151 0.0707 0.2818

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.52 Inhibitory activity against bovine adrenal phenylethanolamine N-methyltransferase (PNMT) ChEMBL. 10091706
Ki (binding) = 4.72 Binding affinity against alpha 2 adrenergic receptor in rat cortex using [3H]-clonidine as radioliagnd ChEMBL. 15686930
Ki (binding) > 1000 Inhibition of [3H]-clonidine binding to the rat alpha2-adrenoceptor ChEMBL. 10091706
Ki (binding) = 0.52 uM Affinity for bovine Phenylethanolamine N-Methyltransferase (PNMT) ChEMBL. 10479290
Ki (binding) = 0.52 uM Inhibition of PNMT (Phenylethanolamine N-Methyltransferase) in vitro ChEMBL. 10464018
Ki (binding) = 0.52 uM Affinity for bovine Phenylethanolamine N-Methyltransferase (PNMT) ChEMBL. 10479290
Ki (binding) = 0.52 uM Inhibition of PNMT (Phenylethanolamine N-Methyltransferase) in vitro ChEMBL. 10464018
Ki (binding) = 3.2 uM Inhibitory activity against human PNMT ChEMBL. 16169723
Ki (binding) = 3.2 uM Inhibition of human PNMT by radiochemical assay ChEMBL. 18024134
Ki (binding) = 3.2 uM Inhibitory activity against human PNMT ChEMBL. 16169723
Ki (binding) = 3.2 uM Inhibition of human PNMT by radiochemical assay ChEMBL. 18024134
Ki (binding) = 4.35 uM Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]-RX-821002 as radioligand ChEMBL. 15686930
Ki (binding) = 4.35 uM Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]-RX-821002 as radioligand ChEMBL. 15686930
Ki (binding) > 1000 uM Compound was tested in vitro for its affinity towards rat Alpha-2 adrenergic receptor ChEMBL. 10479290
Ki (binding) > 1000 uM The compound was tested in vitro for binding affinity against Alpha-2 adrenergic receptor using [3H]clonidine, A precipitate was noted at 1000 microM ChEMBL. 10464018
Ki (binding) > 1000 uM Displacement of [3H]clonidine from Adrenergic alpha2 receptor ChEMBL. 16169723
Ki (binding) > 1000 uM Compound was tested in vitro for its affinity towards rat Alpha-2 adrenergic receptor ChEMBL. 10479290
Ki (binding) > 1000 uM The compound was tested in vitro for binding affinity against Alpha-2 adrenergic receptor using [3H]clonidine, A precipitate was noted at 1000 microM ChEMBL. 10464018
Ki (binding) > 1000 uM Displacement of [3H]clonidine from Adrenergic alpha2 receptor ChEMBL. 16169723
Log Ki (binding) = 0.52 Inhibitory activity against bovine adrenal phenylethanolamine N-methyltransferase (PNMT) ChEMBL. 10091706
Log Ki (binding) = 4.72 Binding affinity against alpha 2 adrenergic receptor in rat cortex using [3H]-clonidine as radioliagnd ChEMBL. 15686930
Log Ki (binding) > 1000 Inhibition of [3H]-clonidine binding to the rat alpha2-adrenoceptor ChEMBL. 10091706
Ratio (binding) = 1900 Ratio for binding affinity towards alpha2 adenoceptor to PNMT ChEMBL. 10479290
Ratio (binding) = 1900 Ratio for binding affinity towards alpha2 adenoceptor to PNMT ChEMBL. 10479290
Ratio Ki (binding) > 310 Selectivity of Adrenergic alpha2 receptor over human PNMT ChEMBL. 16169723
Selectivity (binding) > 1900 Relative affinity for alpha2-adenoceptor and phenylethanolamine N-methyltransferase (PNMT) ChEMBL. 10091706
Selectivity (binding) > 1900 Selectivity determined by Ki of alpha 2 receptor / Ki of PNMT ChEMBL. 10464018

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

6 literature references were collected for this gene.

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