TDR Targets

Basic information

Technical information

TDR Targets ID: 1903369
Name: 6-ethyl-5-methyl-4-oxo-3H-thieno[5,4-d]pyrimi dine-2-carboxylic acid
MW: 238.263 | Formula: C10H10N2O3S
H donors: 2 H acceptors: 5 LogP: 2.59 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CCc1sc2c(c1C)c(O)nc(n2)C(=O)O
InChi: 1S/C10H10N2O3S/c1-3-5-4(2)6-8(13)11-7(10(14)15)12-9(6)16-5/h3H2,1-2H3,(H,14,15)(H,11,12,13)
InChiKey: ZGGVSPXZQQGABP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-ethyl-4-keto-5-methyl-3H-thieno[5,4-d]pyrimidine-2-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0033	0.0271	0.0187
Trypanosoma brucei	Calpain-like protein 2	0.0043	0.0531	0.1675
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0144	0.3168	0.3168
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0271	0.0915
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0895
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0271	0.0915
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0531	0.1789
Echinococcus granulosus	calpain 5	0.0144	0.3168	0.3168
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0144	0.3168	0.3168
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0136	0.2965	1
Trypanosoma brucei	glucosamine 6-phosphate n-acetyltransferase	0.0043	0.0531	0.1675
Plasmodium vivax	vivapain-2	0.0033	0.0271	0.0856
Echinococcus multilocularis	cathepsin L cysteine protease	0.0033	0.0271	0.0271
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0531
Schistosoma mansoni	hypothetical protein	0.0043	0.0531	0.0531
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0271	0.0915
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0033	0.0271	0.5113
Onchocerca volvulus		0.0238	0.5623	1
Echinococcus multilocularis	cathepsin b	0.0405	1	1
Trypanosoma cruzi	kinesin, putative	0.0101	0.2034	0.2034
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0271	0.0271
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0405	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0271	0.0915
Plasmodium falciparum	calpain	0.0043	0.0531	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0271	0.0856
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0033	0.0271	0.0271
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0144	0.3168	0.3168
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0271	0.0856
Trypanosoma cruzi	cysteine peptidase, putative	0.0033	0.0271	0.0271
Loa Loa (eye worm)	calpain 5	0.0101	0.2034	0.1965
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0043	0.0531	0.1789
Entamoeba histolytica	protein kinase, putative	0.0101	0.2034	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0033	0.0271	0.0271
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0531
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0271	0.1333
Loa Loa (eye worm)	hypothetical protein	0.0281	0.6757	0.6729
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0043	0.0531	0.0531
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0531
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0271	0.0856
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0895
Schistosoma mansoni	calpain C (C02 family)	0.0144	0.3168	0.3168
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0531	0.0448
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0399	0.9847	0.9847
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0399	0.9847	0.9847
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0271	0.0915
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0271	0.0187
Trypanosoma brucei	kinesin, putative	0.0101	0.2034	0.6421
Plasmodium vivax	calpain, putative	0.0144	0.3168	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0895
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0271	0.0271
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0271	0.1333
Echinococcus multilocularis	calpain A	0.0399	0.9847	0.9847
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0033	0.0271	0.0271
Trypanosoma cruzi	cysteine peptidase, putative	0.0033	0.0271	0.0271
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0271	0.1333
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0271	0.0915
Schistosoma mansoni	cathepsin F (C01 family)	0.0033	0.0271	0.0271
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0271	0.0915
Onchocerca volvulus	Cathepsin L homolog	0.0033	0.0271	0.0334
Echinococcus multilocularis	cathepsin L cysteine protease	0.0033	0.0271	0.0271
Echinococcus multilocularis	calpain	0.0144	0.3168	0.3168
Loa Loa (eye worm)	hypothetical protein	0.0238	0.5623	0.5585
Leishmania major	calpain family cysteine protease-like protein	0.0043	0.0531	0.0895
Brugia malayi	calpain family protein 1	0.0382	0.9394	0.9394
Loa Loa (eye worm)	calpain family protein 1	0.0382	0.9394	0.9389
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0271	0.0915
Echinococcus multilocularis	cysteine protease	0.0033	0.0271	0.0271
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0043	0.0531	0.1789
Trypanosoma brucei	hypothetical protein	0.0043	0.0531	0.1675
Loa Loa (eye worm)	hypothetical protein	0.0338	0.8261	0.8246
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0271	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0382	0.9394	0.9389
Echinococcus granulosus	calpain	0.0144	0.3168	0.3168
Trichomonas vaginalis	calpain, putative	0.0043	0.0531	0.1789
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0271	0.0915
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0144	0.3168	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0043	0.0531	0.0531
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0144	0.3168	0.3168
Onchocerca volvulus	Cathepsin F homolog	0.0033	0.0271	0.0334
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0144	0.3168	0.3168
Schistosoma mansoni	calpain-7 (C02 family)	0.0144	0.3168	0.3168
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0033	0.0271	0.5113
Echinococcus granulosus	cathepsin b	0.0405	1	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0043	0.0531	0.0531
Brugia malayi	calpain 5	0.0043	0.0531	0.0531
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0043	0.0531	0.1675
Trypanosoma brucei	calpain-like protein, putative	0.0144	0.3168	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0144	0.3168	0.3168
Trypanosoma cruzi	cruzipain precursor, putative	0.0033	0.0271	0.0271
Leishmania major	calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0895
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0144	0.3168	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0271	0.0915
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0399	0.9847	0.9847
Echinococcus multilocularis	calpain 5	0.0144	0.3168	0.3168
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0531
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0271	0.0271
Onchocerca volvulus		0.0033	0.0271	0.0334
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0531
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0144	0.3168	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0271	0.0856
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0033	0.0271	0.0187
Trypanosoma brucei	calpain-like protein, putative	0.0144	0.3168	1
Trypanosoma brucei	Calpain-like protein 1.2	0.0043	0.0531	0.1675
Trypanosoma brucei	Calpain-like protein CALP1.3	0.0043	0.0531	0.1675
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0271	0.0856
Echinococcus granulosus	calpain 7 C02 family	0.0144	0.3168	0.3168
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0101	0.2034	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0033	0.0271	0.0271
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0405	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0405	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0033	0.0271	0.0271
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0271	0.0915
Schistosoma mansoni	calpain-2 (C02 family)	0.0043	0.0531	0.0531
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0144	0.3168	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0271	0.0915
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.0271	0.0271
Leishmania major	cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0895
Echinococcus granulosus	calpain A	0.0399	0.9847	0.9847
Trypanosoma brucei	calpain, putative	0.0043	0.0531	0.1675
Echinococcus multilocularis	cathepsin b	0.0405	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.1675
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0271	0.0915
Brugia malayi	calpain D	0.0043	0.0531	0.0531
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0033	0.0271	0.0915
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0086	0.0291
Trypanosoma brucei	Calpain-like protein 1.1	0.0043	0.0531	0.1675
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0086	0.0086
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0531
Toxoplasma gondii	cathepsin B	0.0136	0.2965	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0033	0.0271	0.0271
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0271	0.0856
Onchocerca volvulus		0.0033	0.0271	0.0334
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0136	0.2965	0.9299
Loa Loa (eye worm)	calpain D	0.0043	0.0531	0.0448
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0026	0.0086	0.0086
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0405	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0271	0.0856
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0895
Brugia malayi	calpain 5	0.0101	0.2034	0.2034
Brugia malayi	calpain family protein 1	0.0382	0.9394	0.9394
Toxoplasma gondii	calpain family cysteine protease domain-containing protein	0.0043	0.0531	0.0963
Trypanosoma cruzi	kinesin, putative	0.0101	0.2034	0.2034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0271	0.0915
Echinococcus granulosus	cathepsin l1	0.0026	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0043	0.0531	0.1789
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0271	0.0915
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.1675
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0895
Brugia malayi	calpain 7	0.0144	0.3168	0.3168
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0531
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0136	0.2965	0.9359
Onchocerca volvulus		0.0033	0.0271	0.0334
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0271	0.0856
Echinococcus multilocularis	calpain family protein 1, d	0.0281	0.6757	0.6757
Trypanosoma brucei	cytoskeleton-associated protein CAP5.5, putative	0.0043	0.0531	0.1675
Loa Loa (eye worm)	cathepsin B	0.0136	0.2965	0.2904
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0144	0.3168	0.3168
Loa Loa (eye worm)	calpain family protein 1	0.0281	0.6757	0.6729
Loa Loa (eye worm)	cysteine protease	0.0033	0.0271	0.0187
Echinococcus multilocularis	hypothetical protein	0.0144	0.3168	0.3168
Schistosoma mansoni	calpain (C02 family)	0.0144	0.3168	0.3168
Leishmania major	calpain protease-like protein	0.0043	0.0531	0.0895
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0271	0.0915
Echinococcus granulosus	calpain A	0.0144	0.3168	0.3168
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0895
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0271	0.0856
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0144	0.3168	0.3168
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0895
Schistosoma mansoni	calpain-7 (C02 family)	0.0144	0.3168	0.3168
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0271	0.0915
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0271	0.0271
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0399	0.9847	0.9847
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0033	0.0271	0.5113
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0405	1	1
Loa Loa (eye worm)	hypothetical protein	0.0405	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0136	0.2965	0.2965
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0043	0.0531	0.1789
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0033	0.0271	0.0915
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0271	0.0915
Echinococcus multilocularis	cysteine protease	0.0033	0.0271	0.0271
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0271	0.0915
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.1675
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0895
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0026	0.0086	0.0086
Trypanosoma brucei	antigen, putative	0.0144	0.3168	1
Trypanosoma brucei	calpain, putative	0.0043	0.0531	0.1675
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0043	0.0531	0.0531
Loa Loa (eye worm)	calpain	0.0144	0.3168	0.3109
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0033	0.0271	0.0271
Trichomonas vaginalis	hypothetical protein	0.0043	0.0531	0.1789
Loa Loa (eye worm)	fibroinase	0.0033	0.0271	0.0187
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0271	0.0856
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0043	0.0531	0.0531
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0895
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0271	0.0915
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0895
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0531
Plasmodium vivax	vivapain-2	0.0033	0.0271	0.0856
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0271	0.0856
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0895
Onchocerca volvulus		0.0033	0.0271	0.0334
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0043	0.0531	0.1789
Giardia lamblia	Cathepsin B precursor	0.0136	0.2965	0.5
Leishmania major	hypothetical protein, conserved	0.0043	0.0531	0.0895
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0382	0.9394	0.9394
Giardia lamblia	Cathepsin B precursor	0.0136	0.2965	0.5
Onchocerca volvulus		0.0033	0.0271	0.0334
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0895
Trypanosoma brucei	cysteine peptidase, putative	0.0043	0.0531	0.1675
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0043	0.0531	0.0531
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0271	0.0915
Leishmania major	kinesin, putative	0.0101	0.2034	0.6086
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0086	0.0424
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0271	0.0915
Brugia malayi	cathepsin L-like precursor	0.0026	0.0086	0.0086
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0895
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0136	0.2965	0.2965
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0086	0.0291
Onchocerca volvulus		0.0033	0.0271	0.0334
Toxoplasma gondii	hypothetical protein	0.0043	0.0531	0.0963
Entamoeba histolytica	calpain family cysteine protease, putative	0.0043	0.0531	0.2608
Loa Loa (eye worm)	ctsf protein	0.0033	0.0271	0.0187
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0043	0.0531	0.1789
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0144	0.3168	1
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0043	0.0531	0.0531
Trichomonas vaginalis	calpain, putative	0.0043	0.0531	0.1789
Giardia lamblia	Cathepsin B precursor	0.0136	0.2965	0.5
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0043	0.0531	0.0531
Trypanosoma cruzi	conserved protein	0.0043	0.0531	0.0531
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0144	0.3168	0.3168
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0043	0.0531	0.0531
Echinococcus granulosus	cathepsin b	0.0405	1	1
Trichomonas vaginalis	calpain, putative	0.0043	0.0531	0.1789
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0144	0.3168	0.3168
Onchocerca volvulus	Cathepsin L homolog	0.0033	0.0271	0.0334
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0271	0.0271
Trypanosoma brucei	calpain-like protein, putative	0.0144	0.3168	1
Leishmania major	hypothetical protein, unknown function	0.0043	0.0531	0.0895
Trypanosoma brucei	calpain-like protein, putative	0.0144	0.3168	1
Echinococcus granulosus	cathepsin l1	0.0033	0.0271	0.0271
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0144	0.3168	0.3168
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0531	0.0895
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0271	0.0271
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0043	0.0531	0.0531
Onchocerca volvulus		0.0033	0.0271	0.0334
Echinococcus multilocularis	calpain 7 (C02 family)	0.0144	0.3168	0.3168

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3306030

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1903369