TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 529.627 | Formula: C31H35N3O5
H donors: 3 H acceptors: 4 LogP: 5.22 Rotable bonds: 17
Rule of 5 violations (Lipinski): 2
SMILES: CC(CC(C(=O)NC(C(=O)C(=O)NCc1ccccc1)Cc1ccccc1)NC(=O)OCc1ccccc1)C
InChi: 1S/C31H35N3O5/c1-22(2)18-27(34-31(38)39-21-25-16-10-5-11-17-25)29(36)33-26(19-23-12-6-3-7-13-23)28(35)30(37)32-20-24-14-8-4-9-15-24/h3-17,22,26-27H,18-21H2,1-2H3,(H,32,37)(H,33,36)(H,34,38)
InChiKey: OMRMJPJSXPRGHA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bos taurus	Cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	calpain 2, (m/II) large subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Calpain-1 catalytic subunit, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Onchocerca volvulus		Get druggable targets OG5_127139	All targets in OG5_127139
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	family C2 unassigned peptidase C02 family	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K08585 calpain, invertebrate, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Calpain-A, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	calpain family protein 1, d	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Cathepsin B	335 aa	275 aa	24.7 %
Brugia malayi	Cathepsin L-like precursor	Cathepsin B	335 aa	312 aa	25.0 %
Plasmodium berghei	dipeptidyl aminopeptidase 1, putative	Cathepsin B	335 aa	313 aa	25.6 %
Toxoplasma gondii	preprocathepsin c precursor, putative	Cathepsin B	335 aa	272 aa	24.3 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	289 aa	22.8 %
Plasmodium knowlesi	knowpain-2	Cathepsin B	335 aa	308 aa	23.1 %
Onchocerca volvulus	Cathepsin L homolog	Cathepsin B	335 aa	316 aa	25.6 %
Dictyostelium discoideum	cathepsin L-like proteinase	Cathepsin B	335 aa	322 aa	26.4 %
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Cathepsin B	335 aa	288 aa	26.4 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	271 aa	25.1 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	297 aa	23.6 %
Schistosoma japonicum	ko:K01275 cathepsin C [EC3.4.14.1], putative	Cathepsin B	335 aa	351 aa	28.5 %
Onchocerca volvulus	Cathepsin B-like cysteine proteinase 6 homolog	Cathepsin B	335 aa	315 aa	49.2 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium yoelii	cathepsin c precursor	Cathepsin B	335 aa	313 aa	25.2 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	272 aa	24.6 %
Neospora caninum	hypothetical protein	Cathepsin B	335 aa	303 aa	28.4 %
Plasmodium berghei	dipeptidyl aminopeptidase 2	Cathepsin B	335 aa	311 aa	22.5 %
Trypanosoma cruzi	cysteine proteinase, putative	Cathepsin B	335 aa	276 aa	25.7 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	297 aa	23.6 %
Toxoplasma gondii	cathepsin CPC1	Cathepsin B	335 aa	296 aa	28.7 %
Onchocerca volvulus		Cathepsin B	335 aa	326 aa	34.7 %
Trypanosoma cruzi	cysteine proteinase, putative	Cathepsin B	335 aa	276 aa	26.1 %
Plasmodium falciparum	dipeptidyl aminopeptidase 2	Cathepsin B	335 aa	312 aa	23.7 %
Cryptosporidium hominis	preprocathepsin c precursor	Cathepsin B	335 aa	280 aa	25.7 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	270 aa	25.2 %
Dictyostelium discoideum	cysteine proteinase 3	Cathepsin B	335 aa	275 aa	28.7 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	272 aa	25.0 %
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	Cathepsin B	335 aa	286 aa	26.6 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	271 aa	25.1 %
Schistosoma japonicum	Cathepsin C precursor, putative	Cathepsin B	335 aa	289 aa	28.4 %
Babesia bovis	cathepsin C precursor, putative	Cathepsin B	335 aa	305 aa	25.9 %
Dictyostelium discoideum	cysteine proteinase 5 precursor	Cathepsin B	335 aa	271 aa	24.4 %
Giardia lamblia	Cathepsin L precursor	Cathepsin B	335 aa	280 aa	25.0 %
Plasmodium knowlesi	knowpain-4	Cathepsin B	335 aa	304 aa	25.3 %
Echinococcus granulosus	calpain A	calpain 2, (m/II) large subunit	622 aa	663 aa	31.2 %
Plasmodium knowlesi	knowpain-3	Cathepsin B	335 aa	301 aa	22.6 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	271 aa	24.4 %
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Cathepsin B	335 aa	287 aa	25.1 %
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	Cathepsin B	335 aa	275 aa	32.7 %
Plasmodium knowlesi	dipeptidyl aminopeptidase 2, putative	Cathepsin B	335 aa	297 aa	24.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Cathepsin L-like cysteine proteinase	0.001	0.0117	0.0117
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0332	1	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0574	0.0574
Trypanosoma brucei	cytoskeleton-associated protein CAP5.5, putative	0.0007	0.004	0.0105
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.001	0.0117	0.0884
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.001	0.0117	0.0368
Brugia malayi	calpain 5	0.0017	0.0344	0.0344
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0109	0.3173	0.3173
Schistosoma mansoni	carbonic anhydrase-related	0.0071	0.1997	0.1997
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.001	0.0117	0.0117
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0009	0.0079	0.0079
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.001	0.0117	0.0117
Giardia lamblia	Cysteine protease	0.001	0.0117	0.0368
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.0105
Leishmania major	cathepsin L-like protease	0.001	0.0117	0.0303
Brugia malayi	sulfakinin receptor protein	0.0035	0.0884	0.0884
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.001	0.0117	0.0117
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.001	0.0117	0.0117
Toxoplasma gondii	cathepsin CPC1	0.001	0.0117	0.0306
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0071	0.1997	0.1997
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.001	0.0117	0.0487
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Chlamydia trachomatis	DNA gyrase subunit B	0.001	0.0115	0.2417
Brugia malayi	calpain 7	0.0025	0.0574	0.0574
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Trypanosoma brucei	DNA topoisomerase IB, large subunit	0.0032	0.0783	0.2036
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.001	0.0117	0.0884
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.001	0.0117	0.0117
Trypanosoma brucei	calpain-like protein, putative	0.0025	0.0574	0.1491
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Leishmania major	DNA topoisomerase 1A	0.001	0.0133	0.0345
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.001	0.0117	0.0117
Trypanosoma brucei	antigen, putative	0.0025	0.0574	0.1491
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.001	0.0117	0.0117
Echinococcus granulosus	phenylalanyl tRNA synthetase alpha chain B	0.0018	0.0352	0.0352
Echinococcus granulosus	thioredoxin domain containing protein 17	0.0013	0.0225	0.0225
Trypanosoma brucei	carbonic anhydrase-like protein	0.0131	0.3848	1
Echinococcus multilocularis	cysteine protease	0.001	0.0117	0.0117
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0009	0.0079	0.0206
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0574	0.1491
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.001	0.0117	0.0117
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.004
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.001	0.0117	0.0884
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0017	0.0319	0.0319
Loa Loa (eye worm)	calpain family protein 1	0.0066	0.1833	0.1833
Leishmania major	cathepsin L-like protease	0.001	0.0117	0.0303
Toxoplasma gondii	phenylalanyl-tRNA synthetase alpha chain A, putative	0.0018	0.0352	0.1053
Schistosoma mansoni	DNA topoisomerase II	0.0017	0.0319	0.0319
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0069	0.1924	0.1924
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.001	0.0117	0.0303
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0071	0.1997	0.1997
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.0105
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.001	0.0117	0.0368
Giardia lamblia	DNA topoisomerase III	0.001	0.0133	0.0418
Plasmodium falciparum	cysteine proteinase falcipain 3	0.001	0.0117	0.0487
Trypanosoma cruzi	phenylalanyl-tRNA synthetase alpha chain, putative	0.0018	0.0352	0.0352
Echinococcus granulosus	carbonic anhydrase	0.0071	0.1997	0.1997
Onchocerca volvulus		0.001	0.0117	0.109
Giardia lamblia	Phenylalanyl-tRNA synthetase alpha chain	0.0018	0.0352	0.111
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0332	1	1
Echinococcus granulosus	DNA topoisomerase 1	0.0042	0.111	0.111
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.001	0.0117	0.0244
Onchocerca volvulus	Cathepsin F homolog	0.001	0.0117	0.109
Trypanosoma cruzi	DNA topoisomerase III, putative	0.0012	0.0179	0.0179
Toxoplasma gondii	cathepsin B	0.0109	0.3173	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.001	0.0117	0.0117
Onchocerca volvulus		0.001	0.0117	0.109
Trypanosoma cruzi	cruzipain precursor, putative	0.001	0.0117	0.0117
Giardia lamblia	Cathepsin B precursor	0.001	0.0117	0.0368
Echinococcus multilocularis	cathepsin b	0.0332	1	1
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.001	0.0117	0.0884
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.001	0.0117	0.0303
Loa Loa (eye worm)	DNA topoisomerase III	0.0012	0.0179	0.0179
Trypanosoma cruzi	cysteine peptidase, putative	0.001	0.0117	0.0117
Echinococcus multilocularis	cathepsin b	0.0332	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.0105
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0117	0.0244
Trichomonas vaginalis	rotamase, putative	0.0009	0.0079	0.0124
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.0105
Echinococcus granulosus	carbonic anhydrase	0.0071	0.1997	0.1997
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0117	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1997	0.1997
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0131	0.3848	0.3848
Brugia malayi	Cathepsin L-like precursor	0.001	0.0117	0.0117
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0009	0.0079	0.2247
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0017	0.0319	0.0948
Trypanosoma brucei	hypothetical protein	0.0007	0.004	0.0105
Loa Loa (eye worm)	hypothetical protein	0.001	0.0117	0.0117
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.001	0.0117	0.0487
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.001	0.0117	0.0487
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Loa Loa (eye worm)	carbonic anhydrase 3	0.0131	0.3848	0.3848
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0117	0.0117
Echinococcus granulosus	expressed protein	0.0009	0.0086	0.0086
Schistosoma mansoni	cathepsin B (C01 family)	0.001	0.0117	0.0117
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0574	0.0574
Entamoeba histolytica	cysteine proteinase, putative	0.001	0.0117	0.3312
Giardia lamblia	Cysteine protease	0.001	0.0117	0.0368
Trypanosoma cruzi	DNA topoisomerase type IB small subunit, putative	0.0011	0.0137	0.0137
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0117	0.0117
Brugia malayi	cathepsin L precursor	0.001	0.0117	0.0117
Trypanosoma cruzi	major cysteine proteinase, putative	0.001	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0225	0.0225
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.0105
Echinococcus multilocularis	cysteine protease	0.001	0.0117	0.0117
Giardia lamblia	Cathepsin B precursor	0.001	0.0117	0.0368
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0013	0.0224	0.0224
Brugia malayi	DNA topoisomerase I	0.0042	0.111	0.111
Leishmania major	calpain family cysteine protease-like protein	0.0007	0.004	0.0105
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0013	0.0212	0.055
Trichomonas vaginalis	phenylalanyl-tRNA synthetase alpha chain, putative	0.0018	0.0352	0.0996
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0117	0.0244
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0332	1	1
Plasmodium vivax	topoisomerase I, putative	0.0042	0.111	1
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0007	0.004	0.004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.001	0.0117	0.0244
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.001	0.0117	0.0303
Plasmodium falciparum	calpain	0.0007	0.004	0.0101
Echinococcus granulosus	cathepsin L cysteine proteinase	0.001	0.0117	0.0117
Giardia lamblia	DNA topoisomerase II	0.0016	0.03	0.0944
Onchocerca volvulus	Cathepsin L homolog	0.001	0.0117	0.109
Schistosoma mansoni	prokaryotic DNA topoisomerase	0.0021	0.0461	0.0461
Loa Loa (eye worm)	cysteine protease	0.001	0.0117	0.0117
Brugia malayi	cathepsin L-like cysteine proteinase	0.001	0.0117	0.0117
Brugia malayi	calpain D	0.0007	0.004	0.004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Giardia lamblia	Cathepsin L-like protease	0.001	0.0117	0.0368
Giardia lamblia	Cathepsin B precursor	0.0109	0.3173	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0574	0.0574
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.001	0.0117	0.0303
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0017	0.0319	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1833	0.1833
Echinococcus granulosus	cathepsin L	0.001	0.0117	0.0117
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0025	0.0574	0.1491
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.001	0.0117	0.0244
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.001	0.0117	0.0117
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0039	0.0996	0.0996
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0025	0.0574	0.0574
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0071	0.1997	0.1997
Echinococcus granulosus	calpain A	0.0025	0.0574	0.0574
Toxoplasma gondii	peptidylprolyl isomerase	0.0009	0.0079	0.0187
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.001	0.0117	0.0117
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0117	0.0117
Plasmodium vivax	phenylalanine--tRNA ligase alpha subunit, putative	0.0018	0.0352	0.3047
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1299	0.1299
Echinococcus multilocularis	calpain 7 (C02 family)	0.0025	0.0574	0.0574
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0017	0.0319	0.0319
Giardia lamblia	Cathepsin L-like protease	0.001	0.0117	0.0368
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.0105
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0007	0.004	0.004
Schistosoma mansoni	DNA topoisomerase type I	0.0042	0.111	0.111
Toxoplasma gondii	hypothetical protein	0.0007	0.004	0.0063
Trypanosoma brucei	Calpain-like protein 1.1	0.0007	0.004	0.0105
Entamoeba histolytica	cysteine proteinase, putative	0.001	0.0117	0.3312
Trypanosoma brucei	calpain-like protein, putative	0.0025	0.0574	0.1491
Echinococcus granulosus	cathepsin l1	0.001	0.0117	0.0117
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0066	0.1833	0.1833
Entamoeba histolytica	cysteine proteinase, putative	0.001	0.0117	0.3312
Loa Loa (eye worm)	hypothetical protein	0.001	0.0117	0.0117
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0574	0.1491
Leishmania major	mitochondrial DNA topoisomerase II	0.0013	0.0224	0.0582
Leishmania major	DNA topoisomerase IB, large subunit	0.0032	0.0783	0.2036
Leishmania major	DNA topoisomerase ii	0.0013	0.0212	0.055
Loa Loa (eye worm)	hypothetical protein	0.001	0.011	0.011
Entamoeba histolytica	protein kinase, putative	0.0017	0.0344	0.9775
Leishmania major	cathepsin L-like protease	0.001	0.0117	0.0303
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.001	0.0117	0.0884
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0013	0.0197	0.1839
Entamoeba histolytica	cysteine proteinase, putative	0.001	0.0117	0.3312
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.001	0.0117	0.0117
Leishmania major	calpain protease-like protein	0.0007	0.004	0.0105
Plasmodium falciparum	cysteine proteinase falcipain 1	0.001	0.0117	0.0487
Schistosoma mansoni	calpain-7 (C02 family)	0.0025	0.0574	0.0574
Schistosoma mansoni	cathepsin F (C01 family)	0.001	0.0117	0.0117
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0009	0.0079	0.0079
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.001	0.0117	0.3312
Giardia lamblia	Cathepsin L precursor	0.001	0.0117	0.0368
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0574	0.0574
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Toxoplasma gondii	DNA topoisomerase I, putative	0.0042	0.111	0.3455
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.0105
Plasmodium vivax	DNA topoisomerase 3, putative	0.001	0.0133	0.103
Toxoplasma gondii	cathepsin CPL	0.001	0.0117	0.0306
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0574	0.1491
Entamoeba histolytica	cysteine proteinase, putative	0.001	0.0117	0.3312
Trypanosoma cruzi	cysteine peptidase, putative	0.001	0.0117	0.0117
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0007	0.004	0.004
Brugia malayi	Cathepsin L-like precursor	0.001	0.0117	0.0117
Chlamydia trachomatis	DNA topoisomerase I	0.002	0.0414	1
Trypanosoma cruzi	DNA topoisomerase IA, putative	0.001	0.0133	0.0133
Onchocerca volvulus		0.001	0.0117	0.109
Giardia lamblia	Cathepsin B precursor	0.001	0.0117	0.0368
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0332	1	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.001	0.0117	0.0117
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Entamoeba histolytica	DNA topoisomerase II, putative	0.0017	0.0319	0.9062
Giardia lamblia	Cathepsin L precursor	0.001	0.0117	0.0368
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0007	0.004	0.0105
Loa Loa (eye worm)	hypothetical protein	0.001	0.0117	0.0117
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.001	0.0117	0.0303
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.001	0.0117	0.0303
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.001	0.0117	0.0117
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0071	0.1997	0.1997
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0574	0.0574
Brugia malayi	hypothetical protein	0.0035	0.0884	0.0884
Toxoplasma gondii	DNA topoisomerase family protein	0.001	0.0133	0.0356
Schistosoma mansoni	cathepsin F (C01 family)	0.001	0.0117	0.0117
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0069	0.1924	0.1924
Echinococcus multilocularis	thioredoxin domain containing protein 17	0.0013	0.0225	0.0225
Trypanosoma brucei	Calpain-like protein 2	0.0007	0.004	0.0105
Brugia malayi	Cathepsin L-like precursor	0.001	0.0117	0.0117
Plasmodium vivax	DNA topoisomerase II, putative	0.0017	0.0319	0.2743
Echinococcus granulosus	calpain A	0.0069	0.1924	0.1924
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0013	0.0212	0.0212
Trichomonas vaginalis	prokaryotic DNA topoisomerase, putative	0.001	0.0133	0.0295
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.001	0.0117	0.0117
Plasmodium falciparum	phenylalanine--tRNA ligase alpha subunit	0.0018	0.0352	0.1679
Trypanosoma cruzi	cysteine protease, putative	0.001	0.0117	0.0117
Leishmania major	carbonic anhydrase-like protein	0.0131	0.3848	1
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0131	0.3848	0.3848
Entamoeba histolytica	hypothetical protein	0.001	0.0117	0.3312
Schistosoma mansoni	phenylalanyl-tRNA synthetase subunit alpha	0.0018	0.0352	0.0352
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0574	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0225	0.0225
Trypanosoma cruzi	DNA topoisomerase IA, putative	0.001	0.0133	0.0133
Brugia malayi	Cathepsin L-like precursor	0.001	0.0117	0.0117
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.001	0.0117	0.0884
Echinococcus multilocularis	DNA topoisomerase 1	0.0042	0.111	0.111
Trypanosoma brucei	DNA topoisomerase type IB small subunit	0.0011	0.0137	0.0357
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.001	0.0117	0.0884
Brugia malayi	cathepsin Z-like cysteine proteinase	0.001	0.0117	0.0117
Echinococcus multilocularis	rho GTPase activating protein 20	0.0012	0.0179	0.0179
Loa Loa (eye worm)	calpain 5	0.0017	0.0344	0.0344
Plasmodium falciparum	serine repeat antigen 1	0.001	0.0117	0.0487
Brugia malayi	calpain 5	0.0007	0.004	0.004
Schistosoma mansoni	rotamase	0.0009	0.0086	0.0086
Toxoplasma gondii	cathepsin CPC2	0.001	0.0117	0.0306
Schistosoma mansoni	DNA topoisomerase type I	0.0032	0.0783	0.0783
Leishmania major	kinesin, putative	0.0017	0.0344	0.0895
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0009	0.0086	0.0086
Plasmodium falciparum	serine repeat antigen 3	0.001	0.0117	0.0487
Echinococcus multilocularis	carbonic anhydrase II	0.0131	0.3848	0.3848
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0071	0.1997	0.1997
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0025	0.0574	0.0574
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0109	0.3173	0.8247
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0007	0.004	0.004
Onchocerca volvulus		0.001	0.0117	0.109
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.001	0.0117	0.0884
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.0105
Schistosoma mansoni	carbonic anhydrase-related	0.0071	0.1997	0.1997
Wolbachia endosymbiont of Brugia malayi	topoisomerase IA, TopA	0.002	0.0414	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0109	0.3173	0.3173
Plasmodium falciparum	serine repeat antigen 6	0.001	0.0117	0.0487
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0009	0.0079	0.0206
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0117	0.0244
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.001	0.0117	0.0244
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0017	0.0319	0.089
Brugia malayi	Cathepsin L-like precursor	0.001	0.0117	0.0117
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0117	0.0244
Trypanosoma cruzi	cysteine peptidase, putative	0.001	0.0117	0.0117
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.001	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.001	0.0117	0.0117
Mycobacterium ulcerans	DNA topoisomerase I	0.001	0.0133	0.3382
Brugia malayi	DNA topoisomerase III	0.0012	0.0179	0.0179
Schistosoma mansoni	hypothetical protein	0.0071	0.1997	0.1997
Leishmania major	phenylalanyl-tRNA synthetase alpha chain, putative	0.0018	0.0352	0.0915
Onchocerca volvulus	Cathepsin L homolog	0.001	0.0117	0.109
Giardia lamblia	Hypothetical protein	0.001	0.0117	0.0368
Plasmodium falciparum	topoisomerase I	0.0042	0.111	0.5511
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Giardia lamblia	Cathepsin L precursor	0.001	0.0117	0.0368
Plasmodium falciparum	serine repeat antigen 4	0.001	0.0117	0.0487
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0013	0.0212	0.0212
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0117	0.0244
Plasmodium vivax	serine-repeat antigen (SERA)	0.001	0.0117	0.0884
Trypanosoma brucei	phenylalanyl-tRNA synthetase alpha chain, putative	0.0018	0.0352	0.0915
Plasmodium falciparum	serine repeat antigen 9	0.001	0.0117	0.0487
Leishmania major	cathepsin L-like protease	0.001	0.0117	0.0303
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.001	0.0117	0.0303
Plasmodium falciparum	serine repeat antigen 5	0.001	0.0117	0.0487
Echinococcus granulosus	calpain	0.0025	0.0574	0.0574
Echinococcus multilocularis	cathepsin L cysteine protease	0.001	0.0117	0.0117
Schistosoma mansoni	hypothetical protein	0.0007	0.004	0.004
Plasmodium vivax	vivapain-3	0.001	0.0117	0.0884
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.001	0.0117	0.0303
Plasmodium falciparum	serine repeat antigen 7	0.001	0.0117	0.0487
Brugia malayi	phenylalanyl (f) trna synthetase protein 1	0.0018	0.0352	0.0352
Trypanosoma brucei	cysteine peptidase, putative	0.0007	0.004	0.0105
Loa Loa (eye worm)	TOPoisomerase family member	0.0017	0.0319	0.0319
Toxoplasma gondii	preprocathepsin c precursor, putative	0.001	0.0117	0.0306
Onchocerca volvulus	Cathepsin L homolog	0.001	0.0117	0.109
Onchocerca volvulus		0.001	0.0117	0.109
Leishmania major	calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.0105
Echinococcus granulosus	calpain 7 C02 family	0.0025	0.0574	0.0574
Brugia malayi	cathepsin L-like precursor	0.001	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.001	0.0117	0.0117
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.004
Echinococcus multilocularis	calpain	0.0025	0.0574	0.0574
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Trypanosoma brucei	DNA topoisomerase ii	0.0013	0.0224	0.0582
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Leishmania major	hypothetical protein, conserved	0.0007	0.004	0.0105
Echinococcus multilocularis	hypothetical protein	0.0025	0.0574	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0007	0.004	0.004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0117	0.0244
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.001	0.0117	0.0244
Echinococcus granulosus	cathepsin L cysteine protease	0.001	0.0117	0.0117
Schistosoma mansoni	carbonic anhydrase	0.0071	0.1997	0.1997
Trypanosoma brucei	glucosamine 6-phosphate n-acetyltransferase	0.0007	0.004	0.0105
Schistosoma mansoni	DNA topoisomerase type I	0.0032	0.0783	0.0783
Loa Loa (eye worm)	ctsf protein	0.001	0.0117	0.0117
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0332	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.001	0.0117	0.0117
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.001	0.0117	0.0368
Trypanosoma brucei	DNA topoisomerase IA, putative	0.001	0.0133	0.0345
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Toxoplasma gondii	hypothetical protein	0.0071	0.1997	0.6269
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.001	0.0117	0.0117
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0007	0.004	0.004
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0574	0.0574
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0131	0.3848	0.3848
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0039	0.0996	0.2589
Brugia malayi	Probable DNA topoisomerase II	0.0017	0.0319	0.0319
Schistosoma mansoni	cathepsin F (C01 family)	0.001	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0008	0.0008
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.001	0.0117	0.0884
Brugia malayi	fibroinase precursor	0.001	0.0117	0.0117
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0117	0.0117
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.004
Toxoplasma gondii	SWI2/SNF2-containing protein	0.0009	0.0092	0.0229
Schistosoma mansoni	calpain (C02 family)	0.0025	0.0574	0.0574
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0117	0.0244
Echinococcus multilocularis	calpain 5	0.0025	0.0574	0.0574
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0131	0.3848	0.3848
Giardia lamblia	Cysteine protease	0.001	0.0117	0.0368
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.0105
Mycobacterium tuberculosis	Probable phenylalanyl-tRNA synthetase, alpha chain PheS	0.0018	0.0352	1
Echinococcus multilocularis	phenylalanyl tRNA synthetase alpha chain B	0.0018	0.0352	0.0352
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0574	0.0574
Schistosoma mansoni	xylosyltransferase	0.0013	0.0225	0.0225
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0009	0.0086	0.0086
Brugia malayi	calpain family protein 1	0.0066	0.1833	0.1833
Giardia lamblia	Hypothetical protein	0.001	0.0117	0.0368
Giardia lamblia	Encystation-specific protease	0.001	0.0117	0.0368
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.004
Echinococcus multilocularis	cathepsin L	0.001	0.0117	0.0117
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.0105
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.0105
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0069	0.1924	0.1924
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.001	0.0117	0.0303
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0069	0.1924	0.1924
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.001	0.0117	0.0244
Loa Loa (eye worm)	hypothetical protein	0.001	0.0117	0.0117
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0574	0.0574
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0117	0.0117
Plasmodium vivax	vivapain-1	0.001	0.0117	0.0884
Echinococcus multilocularis	carbonic anhydrase	0.0071	0.1997	0.1997
Trypanosoma cruzi	conserved protein	0.0007	0.004	0.004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.001	0.0117	0.0487
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0117	0.0244
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Echinococcus multilocularis	expressed protein	0.0009	0.0086	0.0086
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0071	0.1997	0.1997
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.001	0.0117	0.0117
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0574	0.1491
Plasmodium vivax	unspecified product	0.001	0.0117	0.0884
Echinococcus granulosus	cathepsin b	0.0332	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0109	0.3173	1
Brugia malayi	calpain family protein 1	0.0066	0.1833	0.1833
Treponema pallidum	phenylalanyl-tRNA synthetase subunit alpha	0.0018	0.0352	0.843
Loa Loa (eye worm)	hypothetical protein	0.001	0.0117	0.0117
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0131	0.3848	0.3848
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.001	0.0117	0.0117
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.0105
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Trypanosoma brucei	Calpain-like protein CALP1.3	0.0007	0.004	0.0105
Giardia lamblia	Cathepsin B precursor	0.0109	0.3173	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0007	0.004	0.004
Plasmodium vivax	vivapain-2	0.001	0.0117	0.0884
Giardia lamblia	Cathepsin L precursor	0.001	0.0117	0.0368
Echinococcus multilocularis	cathepsin L cysteine protease	0.001	0.0117	0.0117
Onchocerca volvulus		0.001	0.0117	0.109
Trypanosoma brucei	calpain, putative	0.0007	0.004	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0008	0.0008
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0117	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0041	0.107	0.107
Mycobacterium leprae	Probable phenylalanyl-tRNA synthetase, alpha chain PheS	0.0018	0.0352	1
Giardia lamblia	Cysteine protease	0.001	0.0117	0.0368
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0007	0.004	0.004
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0007	0.004	0.004
Trypanosoma cruzi	cysteine peptidase, putative	0.001	0.0117	0.0117
Echinococcus granulosus	calpain 5	0.0025	0.0574	0.0574
Echinococcus granulosus	cysteine protease	0.001	0.0117	0.0117
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0131	0.3848	0.3848
Giardia lamblia	Cathepsin L precursor	0.001	0.0117	0.0368
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0015	0.0281	0.0828
Onchocerca volvulus		0.001	0.0117	0.109
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0884	0.0884
Schistosoma mansoni	calpain-7 (C02 family)	0.0025	0.0574	0.0574
Trypanosoma brucei	calpain, putative	0.0007	0.004	0.0105
Giardia lamblia	Cathepsin B precursor	0.001	0.0117	0.0368
Schistosoma mansoni	calpain-2 (C02 family)	0.0007	0.004	0.004
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Brugia malayi	Cathepsin L-like precursor	0.001	0.0117	0.0117
Onchocerca volvulus		0.001	0.0117	0.109
Brugia malayi	cathepsin Z-like cysteine proteinase	0.001	0.0117	0.0117
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.0105
Plasmodium vivax	serine-repeat antigen (SERA)	0.001	0.0117	0.0884
Entamoeba histolytica	DNA topoisomerase III, putative	0.001	0.0133	0.3763
Echinococcus multilocularis	xylosyltransferase	0.0013	0.0225	0.0225
Leishmania major	cathepsin L-like protease	0.001	0.0117	0.0303
Brugia malayi	Cathepsin L-like precursor	0.001	0.0117	0.0117
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0017	0.0319	0.0319
Schistosoma mansoni	calpain C (C02 family)	0.0025	0.0574	0.0574
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0013	0.0212	0.055
Loa Loa (eye worm)	calpain family protein 1	0.0048	0.1299	0.1299
Echinococcus granulosus	cathepsin l cysteine peptidase	0.001	0.0117	0.0117
Loa Loa (eye worm)	calpain	0.0025	0.0574	0.0574
Echinococcus granulosus	cathepsin l1	0.001	0.0117	0.0117
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.001	0.0117	0.0244
Mycobacterium ulcerans	phenylalanyl-tRNA synthetase subunit alpha	0.0018	0.0352	1
Echinococcus granulosus	carbonic anhydrase II	0.0131	0.3848	0.3848
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0013	0.0197	0.1839
Treponema pallidum	DNA topoisomerase I (topA)	0.002	0.0414	1
Entamoeba histolytica	cysteine proteinase, putative	0.001	0.0117	0.3312
Plasmodium falciparum	DNA topoisomerase 2	0.0017	0.0319	0.1512
Loa Loa (eye worm)	DNA topoisomerase I	0.0042	0.111	0.111
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Schistosoma mansoni	cathepsin S (C01 family)	0.001	0.0117	0.0117
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.001	0.0117	0.3312
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.0105
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.001	0.0117	0.0244
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0007	0.004	0.004
Plasmodium falciparum	carbonic anhydrase	0.0071	0.1997	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.001	0.0117	0.0244
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Echinococcus multilocularis	carbonic anhydrase	0.0071	0.1997	0.1997
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1603	0.1603
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0332	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.001	0.0117	0.0303
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Onchocerca volvulus		0.001	0.0117	0.109
Giardia lamblia	Cathepsin B precursor	0.001	0.0117	0.0368
Echinococcus granulosus	xylosyltransferase	0.0013	0.0225	0.0225
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0109	0.3173	0.8247
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.001	0.0117	0.0117
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0117	0.0244
Schistosoma mansoni	carbonic anhydrase-related	0.0071	0.1997	0.1997
Giardia lamblia	Cathepsin B precursor	0.0109	0.3173	1
Trypanosoma cruzi	cysteine peptidase, putative	0.001	0.0117	0.0117
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0352	0.0352
Trypanosoma brucei	Calpain-like protein 1.2	0.0007	0.004	0.0105
Echinococcus multilocularis	sodium channel protein	0.0039	0.0996	0.0996
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0117	0.0244
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.001	0.0117	0.0244
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Echinococcus granulosus	sodium channel protein	0.0039	0.0996	0.0996
Leishmania major	cysteine peptidase A (CPA)	0.001	0.0117	0.0303
Leishmania major	hypothetical protein, unknown function	0.0007	0.004	0.0105
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.001	0.0117	0.0117
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Plasmodium falciparum	serine repeat antigen 8	0.001	0.0117	0.0487
Loa Loa (eye worm)	hypothetical protein	0.001	0.0117	0.0117
Entamoeba histolytica	cysteine proteinase, putative	0.001	0.0117	0.3312
Plasmodium vivax	vivapain-2	0.001	0.0117	0.0884
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0117	0.0117
Onchocerca volvulus		0.0041	0.107	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.0105
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0117	0.0244
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.0105
Trypanosoma brucei	kinesin, putative	0.0017	0.0344	0.0895
Schistosoma mansoni	cathepsin C	0.001	0.0117	0.0117
Echinococcus multilocularis	cathepsin L	0.001	0.0117	0.0117
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.001	0.0117	0.0884
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.001	0.0117	0.0117
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Loa Loa (eye worm)	calpain D	0.0007	0.004	0.004
Plasmodium vivax	calpain, putative	0.0025	0.0574	0.5078
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.001	0.0117	0.0368
Echinococcus granulosus	carbonic anhydrase	0.0071	0.1997	0.1997
Trypanosoma cruzi	kinesin, putative	0.0017	0.0344	0.0344
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.001	0.0117	0.0244
Trypanosoma cruzi	DNA topoisomerase III, putative	0.0012	0.0179	0.0179
Leishmania major	DNA topoisomerase III, putative	0.0021	0.0461	0.1198
Chlamydia trachomatis	phenylalanine--tRNA ligase subunit alpha	0.0018	0.0352	0.843
Plasmodium vivax	unspecified product	0.001	0.0117	0.0884
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.0105
Leishmania major	cathepsin L-like protease	0.001	0.0117	0.0303
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.001	0.0117	0.0303
Trypanosoma cruzi	kinesin, putative	0.0017	0.0344	0.0344
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0007	0.004	0.004
Entamoeba histolytica	cysteine proteinase 2	0.001	0.0117	0.3312
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.001	0.0117	0.0303
Wolbachia endosymbiont of Brugia malayi	phenylalanyl-tRNA synthetase subunit alpha	0.0018	0.0352	0.843
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1997	0.1997
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1997	0.1997
Entamoeba histolytica	cysteine proteinase 1, putative	0.001	0.0117	0.3312
Loa Loa (eye worm)	hypothetical protein	0.001	0.011	0.011
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0013	0.0197	0.1839
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.001	0.0117	0.0303
Plasmodium falciparum	serine repeat antigen 2	0.001	0.0117	0.0487
Brugia malayi	cathepsin F-like cysteine proteinase	0.001	0.0117	0.0117
Entamoeba histolytica	calpain family cysteine protease, putative	0.0007	0.004	0.1142
Schistosoma mansoni	xylosyltransferase	0.0013	0.0225	0.0225
Trypanosoma brucei	DNA topoisomerase III, putative	0.0012	0.0179	0.0466
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0131	0.3848	0.3848
Giardia lamblia	Cathepsin L precursor	0.001	0.0117	0.0368
Entamoeba histolytica	phenylalanyl-tRNA synthetase alpha subunit, putative	0.0018	0.0352	1
Loa Loa (eye worm)	fibroinase	0.001	0.0117	0.0117
Trichomonas vaginalis	prokaryotic DNA topoisomerase, putative	0.001	0.0133	0.0295
Echinococcus multilocularis	calpain A	0.0069	0.1924	0.1924
Echinococcus granulosus	DNA topoisomerase 3 alpha	0.0012	0.0179	0.0179
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.001	0.0117	0.0487
Loa Loa (eye worm)	cathepsin B	0.0109	0.3173	0.3173
Leishmania major	DNA topoisomerase type IB small subunit	0.0011	0.0137	0.0357
Trypanosoma cruzi	cysteine proteinase, putative	0.001	0.0117	0.0117
Trypanosoma brucei	calpain-like protein, putative	0.0025	0.0574	0.1491
Echinococcus granulosus	cathepsin b	0.0332	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.001	0.0117	0.0117
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0017	0.0344	0.9775
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Trichomonas vaginalis	rotamase, putative	0.0009	0.0086	0.0145
Echinococcus granulosus	cathepsin L	0.001	0.0117	0.0117
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0013	0.0224	0.0224
Entamoeba histolytica	cysteine protease, putative	0.001	0.0117	0.3312
Toxoplasma gondii	calpain family cysteine protease domain-containing protein	0.0007	0.004	0.0063
Trypanosoma cruzi	DNA topoisomerase IB, large subunit, putative	0.0032	0.0783	0.0783
Plasmodium falciparum	DNA topoisomerase 3, putative	0.001	0.0133	0.0568
Leishmania major	cathepsin L-like protease	0.001	0.0117	0.0303
Loa Loa (eye worm)	hypothetical protein	0.001	0.0117	0.0117
Trypanosoma brucei	calpain-like protein, putative	0.0025	0.0574	0.1491
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.001	0.0117	0.0244
Loa Loa (eye worm)	hypothetical protein	0.001	0.0117	0.0117
Brugia malayi	Cathepsin L-like precursor	0.001	0.0117	0.0117
Leishmania major	cathepsin L-like protease	0.001	0.0117	0.0303
Echinococcus multilocularis	carbonic anhydrase	0.0071	0.1997	0.1997
Echinococcus multilocularis	calpain family protein 1, d	0.0048	0.1299	0.1299
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0086	0.0145
Leishmania major	cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative	0.0007	0.004	0.0105

Activities

Activity type	Activity value	Assay description	Source	Reference
IC (functional)	> 300 uM	Platelet membrane permeability.	ChEMBL.	8831774
IC50 (functional)	> 300 uM	Inhibitory potency against rat platelet membrane permeability at pH 7.35	ChEMBL.	8230139
Ki (binding)	= 0.046 nM	Compound was evaluated for the inhibition of Cysteine protease Calpain 2	ChEMBL.	8831774
Ki (binding)	= 4.6 nM	Compound was evaluated for the inhibition of Cathepsin B	ChEMBL.	8831774
Ki (binding)	= 0.046 uM	Inhibitory activity of alpha-keto esters towards calpain 2 at pH 8.0	ChEMBL.	8230139
Ki (binding)	= 0.046 uM	Inhibitory activity of alpha-keto esters towards calpain 2 at pH 8.0	ChEMBL.	8230139
Ki (binding)	= 0.046 uM	Compound was evaluated for the inhibition of Cysteine protease Calpain 2	ChEMBL.	8831774
Ki (binding)	= 4.6 uM	Inhibition of alpha-keto esters towards cathepsin B at pH 5.2	ChEMBL.	8230139
Ki (binding)	= 4.6 uM	Inhibition of alpha-keto esters towards cathepsin B at pH 5.2	ChEMBL.	8230139
Ki (binding)	= 4.6 uM	Compound was evaluated for the inhibition of Cathepsin B	ChEMBL.	8831774

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL419590

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 203409