Detailed information for compound 207649

Basic information

Technical information
  • TDR Targets ID: 207649
  • Name: (2-propan-2-yl-1,3-thiazol-4-yl)methyl N-[(2S )-1-[[(2S,3R)-4-[(2S)-2-(tert-butylcarbamoyl) -4-(pyridin-4-ylmethyl)piperazin-1-yl]-3-hydr oxy-1-phenylbutan-2-yl]amino]-3-methyl-1-oxob utan-2-yl]carbamate
  • MW: 721.952 | Formula: C38H55N7O5S
  • H donors: 4 H acceptors: 6 LogP: 4.42 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@H](C(=O)N[C@H]([C@@H](CN1CCN(C[C@H]1C(=O)NC(C)(C)C)Cc1ccncc1)O)Cc1ccccc1)C(C)C)OCc1csc(n1)C(C)C
  • InChi: 1S/C38H55N7O5S/c1-25(2)33(42-37(49)50-23-29-24-51-36(40-29)26(3)4)35(48)41-30(19-27-11-9-8-10-12-27)32(46)22-45-18-17-44(20-28-13-15-39-16-14-28)21-31(45)34(47)43-38(5,6)7/h8-16,24-26,30-33,46H,17-23H2,1-7H3,(H,41,48)(H,42,49)(H,43,47)/t30-,31-,32+,33-/m0/s1
  • InChiKey: VZZNYJBSHYEULF-SSNHPIBPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2-isopropylthiazol-4-yl)methyl N-[(1S)-1-[[(1S,2R)-1-benzyl-3-[(2S)-2-(tert-butylcarbamoyl)-4-(4-pyridylmethyl)piperazin-1-yl]-2-hydroxy-propyl]carbamoyl]-2-methyl-propyl]carbamate
  • N-[(1S)-1-[[[(1S,2R)-1-benzyl-3-[(2S)-2-[(tert-butylamino)-oxomethyl]-4-(4-pyridylmethyl)-1-piperazinyl]-2-hydroxypropyl]amino]-oxomethyl]-2-methylpropyl]carbamic acid (2-isopropyl-4-thiazolyl)methyl ester
  • (2-propan-2-yl-1,3-thiazol-4-yl)methyl N-[(2S)-1-[[(2S,3R)-4-[(2S)-2-(tert-butylcarbamoyl)-4-(pyridin-4-ylmethyl)piperazin-1-yl]-3-hydroxy-1-phenyl-butan-2-yl]amino]-3-methyl-1-oxo-butan-2-yl]carbamate
  • N-[(1S)-1-[[(1S,2R)-1-benzyl-3-[(2S)-2-(tert-butylcarbamoyl)-4-(4-pyridylmethyl)piperazino]-2-hydroxy-propyl]carbamoyl]-2-methyl-propyl]carbamic acid (2-isopropylthiazol-4-yl)methyl ester
  • (2-isopropylthiazol-4-yl)methyl N-[(1S)-1-[[(1S,2R)-3-[(2S)-2-(tert-butylcarbamoyl)-4-(4-pyridylmethyl)piperazin-1-yl]-2-hydroxy-1-(phenylmethyl)propyl]carbamoyl]-2-methyl-propyl]carbamate
  • N-[(1S)-1-[[[(1S,2R)-3-[(2S)-2-[(tert-butylamino)-oxomethyl]-4-(4-pyridylmethyl)-1-piperazinyl]-2-hydroxy-1-(phenylmethyl)propyl]amino]-oxomethyl]-2-methylpropyl]carbamic acid (2-isopropyl-4-thiazolyl)methyl ester
  • N-[(1S)-1-[[(1S,2R)-1-(benzyl)-3-[(2S)-2-(tert-butylcarbamoyl)-4-(4-pyridylmethyl)piperazin-1-yl]-2-hydroxy-propyl]carbamoyl]-2-methyl-propyl]carbamic acid (2-isopropylthiazol-4-yl)methyl ester
  • (2S)-N-((1S,2R)-3-{2-[N-(tert-Butyl)carbamoyl]-4-(4-pyridylmethyl)piperazinyl}-2-hydroxy-1-benzylpropyl)-3-methyl-2-({[2-(methylethyl)(1,3-thiazol-4-yl)]methoxy}carbonylamino)butanamide
  • AIDS-071429
  • AIDS071429

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Fructose-bisphosphate aldolase 0.0165 0.1816 0.523
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0024 0.0158 0.0266
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.1816 0.5251
Onchocerca volvulus 0.0161 0.1764 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.046 0.046
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0021 0.0117 0.0145
Plasmodium falciparum serine repeat antigen 7 0.005 0.046 0.2307
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0036 0.0293 0.1321
Giardia lamblia Cathepsin L precursor 0.005 0.046 0.117
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.046 0.0413
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.005 0.046 0.2307
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.0069 0.0069
Brugia malayi MH2 domain containing protein 0.008 0.0811 0.0811
Entamoeba histolytica cysteine proteinase, putative 0.0095 0.0988 0.5262
Schistosoma mansoni hypothetical protein 0.0105 0.1108 0.1108
Giardia lamblia Hypothetical protein 0.005 0.046 0.117
Schistosoma mansoni ap endonuclease 0.0017 0.0069 0.0069
Mycobacterium tuberculosis Probable lipase LipE 0.0048 0.0435 0.1073
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0048 0.0435 0.1073
Echinococcus granulosus lysine specific demethylase 6a 0.0021 0.0117 0.0117
Trypanosoma cruzi kinesin, putative 0.0057 0.054 0.0493
Loa Loa (eye worm) hypothetical protein 0.0048 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0035 0.0282 0.0282
Schistosoma mansoni protein phosphatase 2C 0.0021 0.0117 0.0117
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0035 0.0288 0.0288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0828 0.0783
Brugia malayi Pre-SET motif family protein 0.0118 0.126 0.126
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0031 0.0233 0.0233
Onchocerca volvulus 0.0161 0.1764 1
Brugia malayi cathepsin L precursor 0.005 0.046 0.046
Loa Loa (eye worm) beta-lactamase 0.0048 0.0435 0.0435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Brugia malayi Cathepsin L-like cysteine proteinase 0.0116 0.1235 0.1235
Plasmodium vivax serine-repeat antigen (SERA) 0.005 0.046 0.2307
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.046 0.046
Brugia malayi hypothetical protein 0.0134 0.1445 0.1445
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0104 0.1097 0.6068
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0073 0.0073
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0109
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Leishmania major cathepsin L-like protease 0.0161 0.1764 0.5101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Loa Loa (eye worm) TK/ROR protein kinase 0.0035 0.0282 0.0282
Brugia malayi cathepsin F-like cysteine proteinase 0.0045 0.0398 0.0398
Mycobacterium leprae Probable lipase LipE 0.0048 0.0435 0.1768
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0104 0.1097 0.5
Plasmodium falciparum serine repeat antigen 8 0.005 0.046 0.2307
Brugia malayi Cathepsin L-like precursor 0.0116 0.1235 0.1235
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0859 1 1
Brugia malayi calpain D 0.0024 0.0158 0.0158
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.046 0.1209
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0035 0.0282 0.1256
Brugia malayi cathepsin Z-like cysteine proteinase 0.005 0.046 0.046
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.005 0.046 0.117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Onchocerca volvulus 0.0062 0.0606 0.3434
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.046 0.1209
Trypanosoma cruzi cysteine peptidase, putative 0.0045 0.0398 0.0351
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0215 0.241 0.241
Trypanosoma cruzi cysteine peptidase, putative 0.0161 0.1764 0.1723
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.046 0.046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0024 0.0152 0.0477
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.005 0.046 0.1209
Brugia malayi cahepsin L-like non-peptiedase homolog 0.005 0.046 0.046
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0158 0.031
Brugia malayi jmjC domain containing protein 0.0021 0.0117 0.0117
Entamoeba histolytica cysteine proteinase, putative 0.0095 0.0988 0.5262
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0386 0.099
Trichomonas vaginalis maltase-glucoamylase, putative 0.0024 0.0152 0.0292
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0158 0.0109
Giardia lamblia Cathepsin L-like protease 0.005 0.046 0.117
Loa Loa (eye worm) hypothetical protein 0.01 0.1051 0.1051
Giardia lamblia Cathepsin B precursor 0.03 0.341 1
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Leishmania major cathepsin L-like protease 0.0161 0.1764 0.5101
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0104 0.1097 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0386 0.0339
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Brugia malayi latrophilin 2 splice variant baaae 0.0063 0.0616 0.0616
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.03 0.341 0.341
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.005 0.046 0.2307
Onchocerca volvulus 0.01 0.1046 0.5929
Trichomonas vaginalis calpain, putative 0.0024 0.0158 0.031
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.1046 0.1046
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.046 0.1209
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0069 0.0044
Loa Loa (eye worm) fibroinase 0.0161 0.1764 0.1764
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Loa Loa (eye worm) hypothetical protein 0.0116 0.1235 0.1235
Echinococcus multilocularis cathepsin L 0.0095 0.0988 0.0988
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0068 0.0674 0.4744
Loa Loa (eye worm) hypothetical protein 0.0048 0.0435 0.0435
Leishmania major cathepsin L-like protease 0.0161 0.1764 0.5101
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0048 0.0435 0.1073
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.03 0.341 0.3378
Plasmodium falciparum ataxin-2 like protein, putative 0.0019 0.0089 0.0122
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0104 0.1097 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0073 0.0073
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0318 0.2896
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0165 0.1816 1
Toxoplasma gondii hypothetical protein 0.0024 0.0158 0.0266
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0117 0.0117
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0149 0.0149
Echinococcus granulosus calpain A 0.0081 0.0828 0.0828
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0029 0.0215 0.0215
Echinococcus granulosus ubiquitin specific protease 41 0.0044 0.0386 0.0386
Schistosoma mansoni hypothetical protein 0.0029 0.0215 0.0215
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0116 0.1235 0.1192
Brugia malayi Papain family cysteine protease containing protein 0.005 0.046 0.046
Schistosoma mansoni hypothetical protein 0.0029 0.0215 0.0215
Plasmodium vivax JmjC domain containing protein 0.0021 0.0117 0.0285
Loa Loa (eye worm) jmjC domain-containing protein 0.008 0.0808 0.0808
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Echinococcus multilocularis calpain family protein 1, d 0.0159 0.174 0.174
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0161 0.1764 0.1764
Brugia malayi beta-lactamase family protein 0.0048 0.0435 0.0435
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1764 0.5094
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.005 0.046 0.046
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0108 0.1142 0.1142
Loa Loa (eye worm) hypothetical protein 0.0161 0.1764 0.1764
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.0828 0.0783
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0828 0.0783
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Loa Loa (eye worm) transcription factor SMAD2 0.008 0.0811 0.0811
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0386 0.0386
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0158 0.031
Brugia malayi Cathepsin L-like precursor 0.0161 0.1764 0.1764
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0024 0.0152 0.0249
Echinococcus multilocularis survival motor neuron protein 1 0.0134 0.1445 0.1445
Entamoeba histolytica cysteine protease, putative 0.005 0.046 0.2237
Trichomonas vaginalis conserved hypothetical protein 0.005 0.046 0.1209
Trypanosoma brucei hypothetical protein, conserved 0.0048 0.0435 0.1148
Plasmodium falciparum cysteine proteinase falcipain 1 0.0095 0.0988 0.5426
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.046 0.1209
Echinococcus multilocularis cpg binding protein 0.0017 0.0075 0.0075
Echinococcus multilocularis jumonji domain containing 1A 0.0021 0.0117 0.0117
Giardia lamblia Cysteine protease 0.005 0.046 0.117
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.0988 0.0988
Echinococcus multilocularis lysine specific demethylase 5A 0.0079 0.0797 0.0797
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0797 0.0797
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0161 0.1764 0.1764
Schistosoma mansoni hypothetical protein 0.0035 0.0282 0.0282
Toxoplasma gondii cathepsin CPC2 0.005 0.046 0.117
Trypanosoma brucei Calpain-like protein 1.1 0.0024 0.0158 0.0323
Trypanosoma cruzi cysteine proteinase, putative 0.0095 0.0988 0.0944
Echinococcus multilocularis cysteine protease 0.0161 0.1764 0.1764
Schistosoma mansoni Mername-AA248 (C02 family) 0.0081 0.0828 0.0828
Onchocerca volvulus 0.0089 0.0915 0.519
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.005 0.046 0.2307
Echinococcus granulosus cathepsin b 0.0859 1 1
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0049 0.0049
Treponema pallidum fructose-bisphosphate aldolase 0.0165 0.1816 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0017 0.0069 0.002
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0068 0.0674 0.1775
Loa Loa (eye worm) CXXC zinc finger family protein 0.0017 0.0064 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.046 0.1209
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.03 0.341 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.1816 0.5251
Schistosoma mansoni calpain-2 (C02 family) 0.0024 0.0158 0.0158
Brugia malayi Cytochrome P450 family protein 0.0015 0.0049 0.0049
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0158 0.0109
Onchocerca volvulus 0.0027 0.0191 0.1082
Echinococcus multilocularis dnaJ subfamily B 0.0235 0.2643 0.2643
Schistosoma mansoni peptidase Clp (S14 family) 0.0104 0.1097 0.1097
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.005 0.046 0.2307
Trypanosoma cruzi kinesin, putative 0.0057 0.054 0.0493
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0859 1 1
Schistosoma mansoni phosphatidylserine receptor 0.0021 0.0117 0.0117
Mycobacterium tuberculosis Probable lipase LipD 0.0048 0.0435 0.1073
Echinococcus granulosus cathepsin L cysteine proteinase 0.0161 0.1764 0.1764
Echinococcus granulosus lysine specific demethylase 5A 0.008 0.0808 0.0808
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0024 0.015 0.0848
Brugia malayi Latrophilin receptor protein 2 0.0029 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0045 0.0398 0.0398
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.1816 0.5251
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.005 0.046 0.1209
Schistosoma mansoni jumonji/arid domain-containing protein 0.008 0.0808 0.0808
Toxoplasma gondii cathepsin CPC1 0.005 0.046 0.117
Brugia malayi calpain family protein 1 0.0215 0.241 0.241
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0828 0.2317
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0048 0.0435 0.0435
Giardia lamblia Cysteine protease 0.005 0.046 0.117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Brugia malayi Cytochrome P450 family protein 0.0032 0.0248 0.0248
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0095 0.0988 0.2794
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0044 0.0386 0.0386
Loa Loa (eye worm) MH2 domain-containing protein 0.008 0.0811 0.0811
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Giardia lamblia Cathepsin B precursor 0.03 0.341 1
Brugia malayi Protein kinase domain containing protein 0.0035 0.0282 0.0282
Entamoeba histolytica cysteine proteinase, putative 0.0161 0.1764 0.9697
Brugia malayi jmjC domain containing protein 0.008 0.0808 0.0808
Echinococcus granulosus dnaJ subfamily B 0.0235 0.2643 0.2643
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Loa Loa (eye worm) hypothetical protein 0.0021 0.0117 0.0117
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Brugia malayi Glycosyl hydrolases family 31 protein 0.0024 0.0152 0.0152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0031 0.0233 0.0233
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0024 0.0152 0.0292
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0248 0.0248
Onchocerca volvulus 0.0035 0.0282 0.1597
Echinococcus granulosus calpain 0.0081 0.0828 0.0828
Schistosoma mansoni hypothetical protein 0.0027 0.0191 0.0191
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0079 0.0797 0.0797
Trypanosoma brucei Calpain-like protein CALP1.3 0.0024 0.0158 0.0323
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0109
Loa Loa (eye worm) ctsf protein 0.0161 0.1764 0.1764
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0828 0.0783
Trypanosoma brucei calpain-like protein, putative 0.0081 0.0828 0.2317
Echinococcus multilocularis hypothetical protein 0.0081 0.0828 0.0828
Plasmodium vivax vivapain-2 0.0161 0.1764 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0049 0.0049
Trichomonas vaginalis chromobox protein, putative 0.0024 0.015 0.0285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0988 0.2784
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0828 0.0783
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0152 0.0292
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.046 0.1209
Schistosoma mansoni hypothetical protein 0.0029 0.0215 0.0215
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0017 0.0069 0.0626
Plasmodium falciparum serine repeat antigen 5 0.005 0.046 0.2307
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0386 0.0386
Echinococcus granulosus jumonji domain containing 1A 0.0021 0.0117 0.0117
Schistosoma mansoni cpg binding protein 0.0017 0.0064 0.0064
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0036 0.0293 0.1281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Entamoeba histolytica cysteine proteinase, putative 0.0095 0.0988 0.5262
Echinococcus multilocularis neutral alpha glucosidase AB 0.0024 0.0152 0.0152
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Brugia malayi Glycosyl hydrolases family 31 protein 0.0108 0.1142 0.1142
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0081 0.0821 0.2204
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0161 0.1764 0.5094
Trypanosoma brucei Calpain-like protein 2 0.0024 0.0158 0.0323
Loa Loa (eye worm) calpain 0.0081 0.0828 0.0828
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.005 0.046 0.2307
Brugia malayi Papain family cysteine protease containing protein 0.005 0.046 0.046
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0158 0.031
Brugia malayi CXXC zinc finger family protein 0.0017 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0105 0.1108 0.1108
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0109
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0386 0.0386
Mycobacterium ulcerans lipase LipD 0.0048 0.0435 0.3963
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0069 0.0044
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0024 0.0158 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0158 0.031
Loa Loa (eye worm) hypothetical protein 0.0093 0.0961 0.0961
Giardia lamblia Cathepsin L precursor 0.005 0.046 0.117
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0152 0.0292
Trypanosoma cruzi PAB1-binding protein , putative 0.0019 0.0089 0.0041
Plasmodium vivax SET domain protein, putative 0.0017 0.0073 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0233 0.0233
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0386 0.0339
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Loa Loa (eye worm) hypothetical protein 0.0021 0.0117 0.0117
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0095 0.0988 0.0988
Plasmodium vivax vivapain-1 0.0095 0.0988 0.5426
Mycobacterium tuberculosis Conserved protein 0.0048 0.0435 0.1073
Schistosoma mansoni alpha glucosidase 0.0024 0.0152 0.0152
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0225 0.2525 0.2525
Trypanosoma brucei kinesin, putative 0.0057 0.054 0.146
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0158 0.031
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0038 0.0318 0.073
Loa Loa (eye worm) hypothetical protein 0.005 0.046 0.046
Toxoplasma gondii cathepsin B 0.03 0.341 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0038 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0159 0.174 0.174
Brugia malayi calpain 5 0.0057 0.054 0.054
Giardia lamblia Cathepsin L precursor 0.005 0.046 0.117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Echinococcus granulosus chromobox protein 1 0.0039 0.0334 0.0334
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1764 0.5094
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0128 0.0128
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0152 0.0292
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0158 0.0109
Giardia lamblia Cathepsin L precursor 0.005 0.046 0.117
Mycobacterium leprae conserved hypothetical protein 0.0048 0.0435 0.1768
Trypanosoma cruzi cysteine protease, putative 0.0095 0.0988 0.0944
Echinococcus multilocularis ubiquitin specific protease 41 0.0044 0.0386 0.0386
Schistosoma mansoni calpain-7 (C02 family) 0.0085 0.087 0.087
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0044 0.0386 0.0386
Leishmania major cathepsin L-like protease 0.0161 0.1764 0.5101
Loa Loa (eye worm) hypothetical protein 0.0116 0.1235 0.1235
Trypanosoma brucei calpain, putative 0.0024 0.0158 0.0323
Schistosoma mansoni chromobox protein 0.0039 0.0334 0.0334
Leishmania major kinesin, putative 0.0057 0.054 0.146
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.046 0.046
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.046 0.046
Mycobacterium tuberculosis Probable esterase LipL 0.0048 0.0435 0.1073
Schistosoma mansoni cathepsin C 0.005 0.046 0.046
Loa Loa (eye worm) latrophilin receptor protein 2 0.0029 0.0215 0.0215
Onchocerca volvulus 0.0161 0.1764 1
Leishmania major hypothetical protein, conserved 0.0048 0.0435 0.1148
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0152 0.0292
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Schistosoma mansoni ap endonuclease 0.0017 0.0069 0.0069
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Echinococcus multilocularis lysosomal alpha glucosidase 0.0108 0.1142 0.1142
Loa Loa (eye worm) hypothetical protein 0.0017 0.0073 0.0073
Trichomonas vaginalis chromobox protein, putative 0.0039 0.0334 0.0834
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.046 0.1209
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0081 0.0828 0.0783
Schistosoma mansoni cathepsin F (C01 family) 0.0161 0.1764 0.1764
Onchocerca volvulus 0.0017 0.0064 0.0365
Loa Loa (eye worm) hypothetical protein 0.0134 0.1445 0.1445
Echinococcus granulosus JmjC domain containing protein 4 0.0021 0.0117 0.0117
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.1816 0.5251
Schistosoma mansoni calpain-7 (C02 family) 0.0085 0.087 0.087
Loa Loa (eye worm) hypothetical protein 0.01 0.1046 0.1046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.046 0.1209
Entamoeba histolytica hypothetical protein 0.005 0.046 0.2237
Entamoeba histolytica calpain large subunit domain III containing protein 0.0057 0.054 0.2696
Loa Loa (eye worm) hypothetical protein 0.0029 0.0215 0.0215
Entamoeba histolytica papain family cysteine protease domain containing protein 0.005 0.046 0.2237
Trypanosoma brucei Calpain-like protein 1.2 0.0024 0.0158 0.0323
Giardia lamblia Dipeptidyl-peptidase I precursor 0.005 0.046 0.117
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0029 0.0215 0.0215
Plasmodium vivax calpain, putative 0.0081 0.0828 0.448
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0089
Brugia malayi Papain family cysteine protease containing protein 0.005 0.046 0.046
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.005 0.046 0.2307
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0074
Onchocerca volvulus 0.0134 0.1452 0.8232
Giardia lamblia Cathepsin L precursor 0.005 0.046 0.117
Loa Loa (eye worm) heterochromatin protein 1 0.0039 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0048 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0063 0.0616 0.0616
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0024 0.0158 0.0323
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.005 0.046 0.046
Echinococcus granulosus geminin 0.0105 0.1108 0.1108
Brugia malayi beta-lactamase 0.0048 0.0435 0.0435
Brugia malayi Cathepsin L-like precursor 0.0161 0.1764 0.1764
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Onchocerca volvulus Cathepsin F homolog 0.0161 0.1764 1
Trypanosoma brucei PAB1-binding protein , putative 0.0019 0.0089 0.012
Loa Loa (eye worm) hypothetical protein 0.005 0.046 0.046
Onchocerca volvulus Cathepsin L homolog 0.0161 0.1764 1
Echinococcus granulosus tissue type plasminogen activator 0.0035 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0045 0.0398 0.0398
Leishmania major calpain family cysteine protease-like protein 0.0024 0.0158 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.046 0.1209
Giardia lamblia Cysteine protease 0.005 0.046 0.117
Trichomonas vaginalis D-aminoacylase, putative 0.0048 0.0435 0.1135
Brugia malayi Pre-SET motif family protein 0.0017 0.0073 0.0073
Echinococcus multilocularis beta LACTamase domain containing family member 0.0048 0.0435 0.0435
Brugia malayi jmjC domain containing protein 0.0021 0.0117 0.0117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0233 0.0233
Trypanosoma cruzi cruzipain precursor, putative 0.0161 0.1764 0.1723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0017 0.0073 0.0012
Loa Loa (eye worm) cathepsin B 0.03 0.341 0.341
Echinococcus granulosus chromobox protein 1 0.0039 0.0334 0.0334
Brugia malayi Cathepsin L-like precursor 0.0116 0.1235 0.1235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Trypanosoma cruzi cruzipain precursor, putative 0.0045 0.0398 0.0351
Echinococcus multilocularis cathepsin L cysteine protease 0.0161 0.1764 0.1764
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0104 0.1097 1
Echinococcus granulosus survival motor neuron protein 1 0.0134 0.1445 0.1445
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0282 0.0234
Onchocerca volvulus 0.0134 0.1452 0.8232
Brugia malayi jmjC domain containing protein 0.0021 0.0117 0.0117
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0024 0.0158 0.0323
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0306 0.348 1
Echinococcus granulosus cysteine protease 0.0095 0.0988 0.0988
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0109
Trypanosoma cruzi conserved protein 0.0024 0.0158 0.0109
Entamoeba histolytica cysteine proteinase, putative 0.0095 0.0988 0.5262
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Echinococcus granulosus peptidase Clp S14 family 0.0068 0.0674 0.0674
Echinococcus multilocularis cysteine protease 0.0161 0.1764 0.1764
Plasmodium falciparum serine repeat antigen 6 0.005 0.046 0.2307
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0859 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0069 0.002
Schistosoma mansoni calpain (C02 family) 0.0081 0.0828 0.0828
Loa Loa (eye worm) hypothetical protein 0.0048 0.0435 0.0435
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.0049 0.0447
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0386 0.099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.1816 0.5251
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0128 0.0128
Loa Loa (eye worm) cysteine protease 0.0161 0.1764 0.1764
Schistosoma mansoni chromobox protein 0.0039 0.0334 0.0334
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0117 0.0117
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0031 0.0233 0.0233
Echinococcus multilocularis lysine specific demethylase 6a 0.0021 0.0117 0.0117
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0828 0.2317
Toxoplasma gondii histone lysine methyltransferase SET1 0.0032 0.0246 0.053
Brugia malayi chromobox protein homolog 3 0.0022 0.013 0.013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0095 0.0988 0.2794
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.1816 0.5251
Trichomonas vaginalis penicillin-binding protein, putative 0.0048 0.0435 0.1135
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0109
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0081 0.0821 0.748
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0109
Echinococcus multilocularis cathepsin L 0.005 0.046 0.046
Giardia lamblia Dipeptidyl-peptidase I precursor 0.005 0.046 0.117
Loa Loa (eye worm) calpain family protein 1 0.0159 0.174 0.174
Onchocerca volvulus 0.0048 0.0435 0.2465
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0104 0.1097 0.1097
Brugia malayi Calcitonin receptor-like protein seb-1 0.0093 0.0961 0.0961
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0116 0.1235 0.3519
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0161 0.1764 0.5094
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.0828 0.0783
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0044 0.0386 0.1817
Giardia lamblia Hypothetical protein 0.005 0.046 0.117
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Giardia lamblia Cathepsin B precursor 0.005 0.046 0.117
Giardia lamblia Cathepsin L precursor 0.005 0.046 0.117
Schistosoma mansoni jumonji domain containing protein 0.0021 0.0117 0.0117
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.0117 0.0068
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0104 0.1097 0.5
Brugia malayi Papain family cysteine protease containing protein 0.0161 0.1764 0.1764
Loa Loa (eye worm) hypothetical protein 0.0048 0.0435 0.0435
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0161 0.1764 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.03 0.341 1
Giardia lamblia Cathepsin B precursor 0.03 0.341 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0165 0.1816 1
Leishmania major cathepsin L-like protease 0.0161 0.1764 0.5101
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0081 0.0828 0.2317
Giardia lamblia Cathepsin L-like protease 0.005 0.046 0.117
Brugia malayi calpain 7 0.0081 0.0828 0.0828
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.005 0.046 0.046
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0038 0.0318 0.0318
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.0828 0.0783
Entamoeba histolytica protein kinase, putative 0.0057 0.054 0.2696
Echinococcus granulosus beta LACTamase domain containing family member 0.0048 0.0435 0.0435
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0104 0.1097 0.3078
Plasmodium vivax vivapain-2 0.0161 0.1764 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0158 0.0158
Trypanosoma cruzi cysteine peptidase, putative 0.0161 0.1764 0.1723
Mycobacterium tuberculosis Probable hydrolase 0.0048 0.0435 0.1073
Leishmania major hypothetical protein, conserved 0.0024 0.0158 0.0323
Plasmodium falciparum JmjC domain-containing protein, putative 0.0021 0.0117 0.0285
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0048 0.0435 0.1073
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.0069 0.0069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0031 0.0233 0.0233
Brugia malayi jmjC domain containing protein 0.0021 0.0117 0.0117
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0021 0.0117 0.0145
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0073 0.0073
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0093 0.0961 0.0961
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0158 0.031
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0017 0.0073 0.0073
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0117 0.0117
Schistosoma mansoni hypothetical protein 0.0235 0.2643 0.2643
Echinococcus multilocularis chromobox protein 1 0.0039 0.0334 0.0334
Giardia lamblia Cathepsin B precursor 0.005 0.046 0.117
Echinococcus multilocularis calpain 0.0081 0.0828 0.0828
Loa Loa (eye worm) hypothetical protein 0.0134 0.1452 0.1452
Loa Loa (eye worm) hypothetical protein 0.005 0.046 0.046
Schistosoma mansoni cathepsin s 0.0045 0.0398 0.0398
Echinococcus multilocularis calpain A 0.0225 0.2525 0.2525
Echinococcus granulosus cpg binding protein 0.0017 0.0075 0.0075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.1816 0.5251
Leishmania major cysteine peptidase A (CPA) 0.0161 0.1764 0.5101
Echinococcus multilocularis lysosomal alpha glucosidase 0.0108 0.1142 0.1142
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0318 0.2896
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0017 0.0069 0.0059
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.046 0.0413
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0073 0.0073
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.01 0.1051 0.1051
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.1046 0.1046
Brugia malayi beta-lactamase family protein 0.0048 0.0435 0.0435
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.046 0.1209
Brugia malayi Cathepsin L-like precursor 0.0161 0.1764 0.1764
Trichomonas vaginalis D-aminoacylase, putative 0.0048 0.0435 0.1135
Brugia malayi cathepsin L-like precursor 0.0116 0.1235 0.1235
Trichomonas vaginalis penicillin-binding protein, putative 0.0048 0.0435 0.1135
Schistosoma mansoni cathepsin F (C01 family) 0.0161 0.1764 0.1764
Entamoeba histolytica cysteine protease, putative 0.005 0.046 0.2237
Echinococcus multilocularis microtubule associated protein 2 0.039 0.4466 0.4466
Loa Loa (eye worm) hypothetical protein 0.0191 0.2122 0.2122
Loa Loa (eye worm) hypothetical protein 0.0021 0.0117 0.0117
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0029 0.0215 0.0215
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0158 0.0109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1764 0.5094
Trichomonas vaginalis D-aminoacylase, putative 0.0048 0.0435 0.1135
Onchocerca volvulus 0.0048 0.0435 0.2465
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.046 0.046
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0044 0.0386 0.0386
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0233 0.0233
Loa Loa (eye worm) calpain 5 0.0057 0.054 0.054
Echinococcus multilocularis chromobox protein 1 0.0039 0.0334 0.0334
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0161 0.1764 0.1764
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0021 0.0117 0.0117
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0036 0.029 0.029
Onchocerca volvulus 0.0116 0.1235 0.7003
Loa Loa (eye worm) calpain D 0.0024 0.0158 0.0158
Trypanosoma cruzi cysteine peptidase, putative 0.0161 0.1764 0.1723
Echinococcus multilocularis cathepsin L cysteine protease 0.0161 0.1764 0.1764
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0095 0.0988 0.0988
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.046 0.1209
Loa Loa (eye worm) hypothetical protein 0.005 0.046 0.046
Onchocerca volvulus 0.0161 0.1764 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0104 0.1097 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Brugia malayi Cathepsin L-like precursor 0.0161 0.1764 0.1764
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0027 0.0191 0.0191
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.0988 0.0988
Entamoeba histolytica cysteine proteinase, putative 0.0161 0.1764 0.9697
Trichomonas vaginalis conserved hypothetical protein 0.005 0.046 0.1209
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0029 0.0215 0.0215
Trichomonas vaginalis sucrase-isomaltase, putative 0.0024 0.0152 0.0292
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0161 0.1764 1
Trypanosoma brucei calpain-like protein, putative 0.0081 0.0828 0.2317
Plasmodium vivax unspecified product 0.005 0.046 0.2307
Brugia malayi Cytochrome P450 family protein 0.0015 0.0049 0.0049
Onchocerca volvulus 0.0017 0.0074 0.0417
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.0828 0.0783
Plasmodium falciparum calpain 0.0024 0.0158 0.0525
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1764 0.5094
Mycobacterium ulcerans esterase/lipase LipP 0.0048 0.0435 0.3963
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.0117 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0225 0.2525 0.2525
Trichomonas vaginalis set domain proteins, putative 0.0134 0.1452 0.4165
Onchocerca volvulus 0.005 0.046 0.2607
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0165 0.1816 0.5251
Echinococcus multilocularis GPCR, family 2 0.0029 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0045 0.0398 0.0398
Schistosoma mansoni alpha-glucosidase 0.0093 0.0965 0.0965
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0068 0.0674 0.1775
Echinococcus granulosus cathepsin l cysteine peptidase 0.0161 0.1764 0.1764
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0024 0.0158 0.0109
Echinococcus multilocularis JmjC domain containing protein 4 0.0021 0.0117 0.0117
Leishmania major hypothetical protein, conserved 0.0019 0.0089 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Giardia lamblia Cathepsin B precursor 0.005 0.046 0.117
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Trichomonas vaginalis alpha-glucosidase, putative 0.0024 0.0152 0.0292
Brugia malayi Cathepsin L-like precursor 0.0161 0.1764 0.1764
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0386 0.099
Trypanosoma cruzi cysteine peptidase, putative 0.0161 0.1764 0.1723
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0093 0.0961 0.0961
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0031 0.0233 0.0233
Schistosoma mansoni jumonji/arid domain-containing protein 0.008 0.0808 0.0808
Schistosoma mansoni cathepsin S (C01 family) 0.005 0.046 0.046
Brugia malayi calpain 5 0.0024 0.0158 0.0158
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0045 0.0398 0.0398
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0048 0.0435 0.3963
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.005 0.046 0.2307
Echinococcus multilocularis cathepsin b 0.0859 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0048 0.0435 0.0435
Entamoeba histolytica cysteine proteinase, putative 0.0116 0.1235 0.6673
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0095 0.0988 0.0988
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0073 0.0073
Trypanosoma brucei hypothetical protein 0.0024 0.0158 0.0323
Echinococcus granulosus cathepsin L cysteine protease 0.0095 0.0988 0.0988
Leishmania major cathepsin L-like protease 0.0161 0.1764 0.5101
Giardia lamblia Cathepsin B precursor 0.005 0.046 0.117
Onchocerca volvulus 0.0048 0.0435 0.2465
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0435 0.216
Entamoeba histolytica cysteine protease, putative 0.005 0.046 0.2237
Brugia malayi hypothetical protein 0.0019 0.0089 0.0089
Toxoplasma gondii hypothetical protein 0.0036 0.0293 0.067
Giardia lamblia Cysteine protease 0.005 0.046 0.117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Trypanosoma cruzi cysteine proteinase, putative 0.0095 0.0988 0.0944
Entamoeba histolytica cysteine protease, putative 0.005 0.046 0.2237
Brugia malayi hypothetical protein 0.0012 0.0011 0.0011
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0104 0.1097 0.3078
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0158 0.0109
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.005 0.046 0.2307
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0024 0.0152 0.0477
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0152 0.0103
Mycobacterium tuberculosis Conserved protein 0.0048 0.0435 0.1073
Schistosoma mansoni cathepsin F (C01 family) 0.0116 0.1235 0.1235
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0024 0.0158 0.031
Loa Loa (eye worm) hypothetical protein 0.0104 0.1097 0.1097
Brugia malayi jmjC domain containing protein 0.0079 0.0797 0.0797
Schistosoma mansoni cathepsin B (C01 family) 0.005 0.046 0.046
Echinococcus granulosus cathepsin l1 0.0161 0.1764 0.1764
Plasmodium vivax serine-repeat antigen (SERA) 0.005 0.046 0.2307
Plasmodium falciparum serine repeat antigen 2 0.005 0.046 0.2307
Brugia malayi Kringle domain containing protein 0.0035 0.0282 0.0282
Trichomonas vaginalis esterase, putative 0.0048 0.0435 0.1135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0022 0.013 0.0736
Onchocerca volvulus 0.0024 0.0149 0.0843
Plasmodium falciparum serine repeat antigen 9 0.005 0.046 0.2307
Plasmodium vivax unspecified product 0.0095 0.0988 0.5426
Giardia lamblia Encystation-specific protease 0.005 0.046 0.117
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0435 0.0388
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0152 0.0103
Trypanosoma brucei cysteine peptidase C (CPC) 0.03 0.341 1
Leishmania major hypothetical protein, conserved 0.0021 0.0117 0.0202
Schistosoma mansoni cpg binding protein 0.0017 0.0075 0.0075
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0828 0.2317
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0038 0.0318 0.0318
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0045 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.0044 0.0386 0.0386
Echinococcus granulosus cathepsin b 0.0859 1 1
Entamoeba histolytica cysteine protease, putative 0.005 0.046 0.2237
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0104 0.1097 0.1097
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.1019 0.2875
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.005 0.046 0.2307
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0859 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0048 0.0435 0.0435
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0225 0.2525 0.2525
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.005 0.046 0.1209
Loa Loa (eye worm) hypothetical protein 0.005 0.046 0.046
Echinococcus granulosus calpain 7 C02 family 0.0081 0.0828 0.0828
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0021 0.0117 0.0202
Plasmodium vivax serine-repeat antigen (SERA), putative 0.005 0.046 0.2307
Plasmodium vivax serine-repeat antigen (SERA), putative 0.005 0.046 0.2307
Echinococcus granulosus cathepsin l1 0.0116 0.1235 0.1235
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0081 0.0828 0.2317
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0044 0.0386 0.1003
Echinococcus granulosus microtubule associated protein 2 0.039 0.4466 0.4466
Plasmodium vivax unspecified product 0.0045 0.0398 0.1944
Echinococcus granulosus cathepsin L 0.005 0.046 0.046
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.005 0.046 0.1209
Loa Loa (eye worm) calpain family protein 1 0.0215 0.241 0.241
Plasmodium falciparum cysteine repeat modular protein 1 0.0035 0.0282 0.1256
Toxoplasma gondii cathepsin CPL 0.0161 0.1764 0.5072
Trichomonas vaginalis calpain, putative 0.0024 0.0158 0.031
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0038 0.0318 0.0318
Mycobacterium ulcerans beta-lactamase 0.0048 0.0435 0.3963
Echinococcus granulosus neutral alpha glucosidase AB 0.0024 0.0152 0.0152
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0024 0.0158 0.0109
Leishmania major hypothetical protein, unknown function 0.0024 0.0158 0.0323
Brugia malayi cathepsin F-like cysteine proteinase 0.005 0.046 0.046
Trypanosoma brucei cysteine peptidase, putative 0.0024 0.0158 0.0323
Echinococcus multilocularis peptidase Clp (S14 family) 0.0068 0.0674 0.0674
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.005 0.046 0.2307
Trichomonas vaginalis calpain, putative 0.0024 0.0158 0.031
Trypanosoma cruzi PAB1-binding protein , putative 0.0019 0.0089 0.0041
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1764 0.5094
Trichomonas vaginalis chromobox protein, putative 0.0039 0.0334 0.0834
Loa Loa (eye worm) hypothetical protein 0.0859 1 1
Echinococcus multilocularis calpain 7 (C02 family) 0.0081 0.0828 0.0828
Onchocerca volvulus Cathepsin L homolog 0.005 0.046 0.2607
Echinococcus granulosus cathepsin L 0.0095 0.0988 0.0988
Schistosoma mansoni cpg binding protein 0.0017 0.0075 0.0075
Leishmania major calpain protease-like protein 0.0024 0.0158 0.0323
Entamoeba histolytica cysteine proteinase 2 0.0095 0.0988 0.5262
Echinococcus granulosus calpain 5 0.0081 0.0828 0.0828
Entamoeba histolytica cysteine protease, putative 0.005 0.046 0.2237
Echinococcus multilocularis calpain 5 0.0081 0.0828 0.0828
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0038 0.0318 0.0799
Plasmodium falciparum cysteine proteinase falcipain 3 0.0161 0.1764 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0095 0.0988 0.5262
Entamoeba histolytica calpain family cysteine protease, putative 0.0024 0.0158 0.0509
Echinococcus granulosus lysosomal alpha glucosidase 0.0108 0.1142 0.1142
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.005 0.046 0.046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.046 0.1209
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.046 0.1209
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0029 0.0215 0.0215
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0016 0.0061 0.0061
Plasmodium falciparum serine repeat antigen 1 0.005 0.046 0.2307
Brugia malayi Trypsin family protein 0.01 0.1046 0.1046
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0049 0.0049
Schistosoma mansoni survival motor neuron protein 0.0027 0.0191 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0988 0.2784
Toxoplasma gondii LsmAD domain-containing protein 0.0019 0.0089 0.0062
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0081 0.0821 0.6564
Echinococcus multilocularis geminin 0.0105 0.1108 0.1108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1764 0.5094
Schistosoma mansoni hypothetical protein 0.0024 0.0158 0.0158
Leishmania major hypothetical protein, conserved 0.0035 0.0282 0.0692
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Toxoplasma gondii kringle domain-containing protein 0.0035 0.0282 0.0637
Trypanosoma brucei calpain-like protein, putative 0.0081 0.0828 0.2317
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0104 0.1097 0.5884
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Brugia malayi Probable ClpP-like protease 0.0104 0.1097 0.1097
Echinococcus granulosus phd:f box containing protein 0.0021 0.0117 0.0117
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0036 0.0293 0.1321
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0024 0.0152 0.0292
Schistosoma mansoni hypothetical protein 0.0063 0.0616 0.0616
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0081 0.0828 0.0783
Plasmodium vivax ataxin-2 like protein, putative 0.0019 0.0089 0.0122
Onchocerca volvulus 0.0161 0.1764 1
Plasmodium falciparum serine repeat antigen 4 0.005 0.046 0.2307
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.0069 0.0069
Entamoeba histolytica cysteine protease, putative 0.0161 0.1764 0.9697
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0079 0.0797 0.0797
Mycobacterium tuberculosis Conserved protein 0.0048 0.0435 0.1073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.005 0.046 0.046
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Trypanosoma brucei calpain-like protein, putative 0.0081 0.0828 0.2317
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0104 0.1097 0.6068
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0161 0.1764 0.1764
Giardia lamblia Cathepsin B precursor 0.005 0.046 0.117
Loa Loa (eye worm) hypothetical protein 0.005 0.046 0.046
Onchocerca volvulus Cathepsin L homolog 0.0161 0.1764 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Brugia malayi fibroinase precursor 0.005 0.046 0.046
Plasmodium falciparum serine repeat antigen 3 0.005 0.046 0.2307
Trypanosoma cruzi cysteine peptidase, putative 0.0095 0.0988 0.0944
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0225 0.2525 0.2525
Echinococcus granulosus GPCR family 2 0.0029 0.0215 0.0215
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0044 0.0386 0.095
Loa Loa (eye worm) hypothetical protein 0.0048 0.0435 0.0435
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1764 0.5094
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0386 0.1003
Onchocerca volvulus 0.0161 0.1764 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0118 0.126 0.126
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0048 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0022 0.013 0.013
Plasmodium vivax vivapain-3 0.0095 0.0988 0.5426
Entamoeba histolytica papain family cysteine protease domain containing protein 0.005 0.046 0.2237
Echinococcus multilocularis tissue type plasminogen activator 0.0035 0.0282 0.0282
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0859 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0435 0.0388
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0017 0.0069 0.0059
Mycobacterium ulcerans hypothetical protein 0.0048 0.0435 0.3963
Giardia lamblia Dipeptidyl-peptidase I precursor 0.005 0.046 0.117
Brugia malayi calpain family protein 1 0.0215 0.241 0.241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0161 0.1764 0.5094
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.005 0.046 0.2307
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0031 0.0233 0.0233
Onchocerca volvulus 0.0161 0.1764 1
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0024 0.0158 0.0109
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0095 0.0988 0.0944
Echinococcus multilocularis phd:f box containing protein 0.0021 0.0117 0.0117
Echinococcus granulosus calpain A 0.0225 0.2525 0.2525
Schistosoma mansoni alpha-glucosidase 0.0093 0.0965 0.0965
Trypanosoma brucei antigen, putative 0.0081 0.0828 0.2317
Plasmodium falciparum ataxin-2 like protein, putative 0.0019 0.0089 0.0122
Toxoplasma gondii preprocathepsin c precursor, putative 0.005 0.046 0.117
Trypanosoma brucei glucosidase, putative 0.0024 0.0152 0.0306
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0386 0.0386
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0109
Loa Loa (eye worm) hypothetical protein 0.01 0.1046 0.1046
Brugia malayi Cathepsin L-like precursor 0.0161 0.1764 0.1764
Schistosoma mansoni calpain C (C02 family) 0.0081 0.0828 0.0828
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Echinococcus multilocularis cathepsin b 0.0859 1 1
Leishmania major cathepsin L-like protease 0.0161 0.1764 0.5101
Leishmania major alpha glucosidase II subunit, putative 0.0024 0.0152 0.0306
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.013 0.0226
Brugia malayi Heterochromatin protein 1 0.0039 0.0334 0.0334
Toxoplasma gondii ABC1 family protein 0.0048 0.0435 0.1095
Trichomonas vaginalis chromobox protein, putative 0.0024 0.015 0.0285
Schistosoma mansoni phd/f-box containing protein 0.0021 0.0117 0.0117
Brugia malayi cathepsin L-like cysteine proteinase 0.005 0.046 0.046
Trypanosoma brucei calpain, putative 0.0024 0.0158 0.0323
Entamoeba histolytica cysteine protease, putative 0.0095 0.0988 0.5262
Schistosoma mansoni microtubule-associated protein tau 0.039 0.4466 0.4466
Brugia malayi Cathepsin L-like precursor 0.0045 0.0398 0.0398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0161 0.1764 0.5101
Trichomonas vaginalis hypothetical protein 0.0024 0.0158 0.031
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0024 0.0158 0.0109
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0024 0.0158 0.0323
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.013 0.0226
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1764 0.5094
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0024 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0215 0.241 0.241
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.046 0.046
Loa Loa (eye worm) hypothetical protein 0.0116 0.1235 0.1235
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0161 0.1764 0.5094
Brugia malayi cathepsin Z-like cysteine proteinase 0.005 0.046 0.046
Leishmania major cathepsin L-like protease 0.0161 0.1764 0.5101
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0024 0.0158 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0116 0.1235 0.3519
Schistosoma mansoni hypothetical protein 0.0029 0.0215 0.0215

Activities

Activity type Activity value Assay description Source Reference
CCIC50 (functional) = 56 uM Cytotoxicity against MT-4 cells was determined by using cytopathic effect assay ChEMBL. 9934466
CCIC50 (functional) = 56 uM Cytotoxicity against MT-4 cells was determined by using cytopathic effect assay ChEMBL. 9934466
EC50 (functional) = 0.017 uM Anti-HIV activity was determined in MT-4 cells in the presence of 0% human serum using cytopathic effect assay ChEMBL. 9934466
EC50 (functional) = 0.076 uM Anti-HIV activity was determined in MT-4 cells in the presence of 50% human serum using cytopathic effect assay ChEMBL. 9934466
Inhibition (binding) = 73 % Inhibition of HIV protease at 0.5 nM ChEMBL. 9934466
Inhibition (binding) = 73 % Inhibition of HIV protease at 0.5 nM ChEMBL. 9934466

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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