Detailed information for compound 323906

Basic information

Technical information
  • TDR Targets ID: 323906
  • Name: 2-(4-chlorophenoxy)-N-[4-methyl-2-(4-methylpi perazin-1-yl)quinolin-6-yl]acetamide
  • MW: 424.923 | Formula: C23H25ClN4O2
  • H donors: 1 H acceptors: 2 LogP: 4.32 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)c1cc(C)c2c(n1)ccc(c2)NC(=O)COc1ccc(cc1)Cl
  • InChi: 1S/C23H25ClN4O2/c1-16-13-22(28-11-9-27(2)10-12-28)26-21-8-5-18(14-20(16)21)25-23(29)15-30-19-6-3-17(24)4-7-19/h3-8,13-14H,9-12,15H2,1-2H3,(H,25,29)
  • InChiKey: OKIVGPUCUWMOIH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-chlorophenoxy)-N-[4-methyl-2-(4-methylpiperazin-1-yl)-6-quinolyl]acetamide
  • 2-(4-chlorophenoxy)-N-[4-methyl-2-(4-methyl-1-piperazinyl)-6-quinolyl]acetamide
  • 2-(4-chlorophenoxy)-N-[4-methyl-2-(4-methylpiperazin-1-yl)quinolin-6-yl]ethanamide
  • 2-(4-chlorophenoxy)-N-[4-methyl-2-(4-methylpiperazino)-6-quinolyl]acetamide
  • EU-0088874

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Starlite/ChEMBL References
Homo sapiens melanin-concentrating hormone receptor 1 Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_144688 All targets in OG5_144688
Echinococcus granulosus hypothetical protein Get druggable targets OG5_144688 All targets in OG5_144688
Brugia malayi Serotonin receptor Get druggable targets OG5_135430 All targets in OG5_135430
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Schistosoma mansoni opsin-like receptor 0.0229 0.1357 0.1509
Schistosoma mansoni amine GPCR 0.0229 0.1357 0.1509
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0036 0.0083
Brugia malayi AKH receptor 0.0229 0.1357 0.1512
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0229 0.1357 0.1512
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0019
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0005 0.0004
Brugia malayi putative neuropeptide receptor 0.0229 0.1357 0.1512
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0221 0.0241
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.0067
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0036 0.0035
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0062 0.0068
Brugia malayi Protein kinase domain containing protein 0.0015 0.0028 0.0032
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0219 0.1458
Brugia malayi intermediate filament protein 0.0027 0.0108 0.012
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0221 0.0241
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0221 0.0245
Schistosoma mansoni neuropeptide receptor 0.0229 0.1357 0.1509
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0018 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0128 0.0137
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0018 0.0014
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0229 0.1357 0.1509
Echinococcus multilocularis rhodopsin orphan GPCR 0.0229 0.1357 0.1512
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Onchocerca volvulus 0.0229 0.1357 0.9557
Echinococcus granulosus sex peptide receptor 0.0229 0.1357 0.1356
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0065 0.0157
Echinococcus multilocularis RUN 0.002 0.0062 0.0068
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0036 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.0067
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.0892 0.099
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.006 0.0144
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0221 0.0241
Schistosoma mansoni opsin-like receptor 0.0229 0.1357 0.1509
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0229 0.1357 0.1356
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0229 0.1357 0.1512
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Brugia malayi PAS domain containing protein 0.0049 0.0244 0.0272
Schistosoma mansoni biogenic amine (5HT) receptor 0.0229 0.1357 0.1509
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0221 0.022
Echinococcus granulosus neuropeptides capa receptor 0.0229 0.1357 0.1356
Echinococcus granulosus neuropeptide Y receptor 0.0229 0.1357 0.1356
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0097 0.0102
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0097 0.0102
Brugia malayi G-protein coupled receptor 0.0229 0.1357 0.1512
Echinococcus granulosus neuropeptide s receptor 0.0229 0.1357 0.1356
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0018 0.0026
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0191 0.0208
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0018 0.0014
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0462 0.2804 0.3126
Loa Loa (eye worm) hypothetical protein 0.0031 0.0128 0.0142
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0229 0.1357 0.1509
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0229 0.1357 0.1509
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Loa Loa (eye worm) hypothetical protein 0.0649 0.3963 0.4417
Echinococcus granulosus rhodopsin orphan GPCR 0.0229 0.1357 0.1356
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0062 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0018 0.0026
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0036 0.004
Onchocerca volvulus 0.0229 0.1357 0.9557
Schistosoma mansoni biogenic amine receptor 0.0229 0.1357 0.1509
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0229 0.1357 0.1509
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0033 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.0067
Echinococcus multilocularis G-protein coupled receptor, putative 0.0229 0.1357 0.1512
Trypanosoma brucei unspecified product 0.0014 0.0026 0.0023
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0065 0.0067
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0036 0.004
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0065 0.0067
Echinococcus granulosus rhodopsin orphan GPCR 0.0229 0.1357 0.1356
Echinococcus multilocularis somatostatin receptor 0.0229 0.1357 0.1512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0148 0.0958
Echinococcus multilocularis neuropeptide s receptor 0.0229 0.1357 0.1512
Echinococcus granulosus microtubule associated protein 2 0.0758 0.4638 0.4638
Brugia malayi follicle stimulating hormone receptor 0.0462 0.2804 0.3126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0148 0.0958
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0128 0.0137
Brugia malayi hypothetical protein 0.0229 0.1357 0.1512
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0229 0.1357 0.1509
Echinococcus multilocularis serotonin receptor 0.1455 0.8966 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0352 0.0905
Loa Loa (eye worm) hypothetical protein 0.1456 0.8971 1
Brugia malayi Serotonin receptor 0.1157 0.7119 0.7936
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0221 0.0246
Brugia malayi Cytochrome P450 family protein 0.002 0.006 0.0067
Brugia malayi Cytochrome P450 family protein 0.002 0.006 0.0067
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0221 0.2322
Echinococcus multilocularis neuropeptides capa receptor 0.0229 0.1357 0.1512
Brugia malayi Doublecortin family protein 0.002 0.0062 0.0069
Leishmania major clathrin coat assembly protein AP17, putative 0.0129 0.0736 0.0815
Loa Loa (eye worm) neuropeptide F receptor 0.0229 0.1357 0.1512
Brugia malayi hypothetical protein 0.0229 0.1357 0.1512
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0155 0.1004
Onchocerca volvulus 0.0027 0.0108 0.0643
Brugia malayi sulfakinin receptor protein 0.0229 0.1357 0.1512
Echinococcus granulosus lamin dm0 0.0027 0.0108 0.0107
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0033 0.0031
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0195 0.1941
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0036 0.004
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0352 0.0905
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0065 0.0067
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0009 0.0008
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0033 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.0067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0229 0.1357 0.1509
Schistosoma mansoni growth hormone secretagogue receptor 0.0229 0.1357 0.1509
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0229 0.1357 0.1512
Echinococcus multilocularis rhodopsin orphan GPCR 0.0229 0.1357 0.1512
Onchocerca volvulus 0.0229 0.1357 0.9557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0033 0.0135
Trypanosoma brucei cytochrome P450, putative 0.002 0.006 0.0062
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0128 0.0142
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0028 0.0026
Echinococcus multilocularis tumor protein p63 0.0343 0.2065 0.2302
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0229 0.1357 0.1512
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0026 0.0023
Brugia malayi neuropeptide F receptor 0.0229 0.1357 0.1512
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Onchocerca volvulus 0.002 0.0062 0.0318
Echinococcus granulosus dna polymerase kappa 0.002 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0155 0.1004
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0065 0.0072
Trichomonas vaginalis set domain proteins, putative 0.0239 0.1418 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.0067
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.006 0.0066
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0036 0.0035
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0005 0.0004
Schistosoma mansoni myosin xvIII 0.0229 0.1357 0.1509
Echinococcus multilocularis rhodopsin orphan GPCR 0.0229 0.1357 0.1512
Brugia malayi hypothetical protein 0.0017 0.004 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0221 0.1474
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0028 0.0032
Brugia malayi hypothetical protein 0.0229 0.1357 0.1512
Echinococcus granulosus tm gpcr rhodopsin 0.0229 0.1357 0.1356
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0249 0.0273
Brugia malayi G-protein coupled receptor 0.0229 0.1357 0.1512
Echinococcus granulosus biogenic amine 5HT receptor 0.1455 0.8966 0.8966
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0229 0.1357 0.1509
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0065 0.0067
Onchocerca volvulus 0.0229 0.1357 0.9557
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0229 0.1357 0.1509
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0229 0.1357 0.1512
Echinococcus granulosus alpha 1A adrenergic receptor 0.0229 0.1357 0.1356
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0018 0.0026
Echinococcus multilocularis dna polymerase eta 0.002 0.0065 0.0072
Giardia lamblia GTOR 0.0046 0.0221 0.2322
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0229 0.1357 0.1512
Echinococcus multilocularis 0.0011 0.0005 0.0005
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0033 0.0031
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0036 0.0035
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0328 0.0361
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0097 0.1256
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0018 0.0019
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0229 0.1357 0.9557
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0062 0.0367
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0229 0.1357 0.1512
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.0067
Brugia malayi Death domain containing protein 0.0015 0.0028 0.0032
Onchocerca volvulus 0.0239 0.1419 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0033 0.0036
Echinococcus multilocularis cpg binding protein 0.0031 0.0129 0.0143
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0065 0.0067
Loa Loa (eye worm) hypoxia-induced factor 1 0.0153 0.0886 0.0986
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0148 0.0958
Brugia malayi Dopamine receptor 0.0229 0.1357 0.1512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0033 0.0135
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0352 0.0351
Schistosoma mansoni biogenic amine (5HT) receptor 0.1455 0.8966 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.0067
Schistosoma mansoni neuropeptide receptor 0.0229 0.1357 0.1509
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0062 0.0367
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0229 0.1357 0.1512
Echinococcus multilocularis sex peptide receptor 0.0229 0.1357 0.1512
Echinococcus multilocularis neuropeptide receptor 0.0229 0.1357 0.1512
Echinococcus granulosus g protein coupled receptor 0.0229 0.1357 0.1356
Brugia malayi clathrin adaptor complex small chain 0.0129 0.0736 0.082
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0229 0.1357 0.1512
Schistosoma mansoni DNA polymerase eta 0.002 0.0065 0.0067
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0005 0.0005
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0028 0.0031
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1456 0.8971 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0105 0.0651
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0062 0.0061
Schistosoma mansoni alpha-1 adrenergic receptor 0.0229 0.1357 0.1509
Onchocerca volvulus 0.0037 0.0165 0.1049
Echinococcus granulosus biogenic amine 5HT receptor 0.0229 0.1357 0.1356
Echinococcus multilocularis allatostatin A receptor 0.0229 0.1357 0.1512
Onchocerca volvulus 0.0229 0.1357 0.9557
Brugia malayi RE15519p 0.0229 0.1357 0.1512
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Onchocerca volvulus 0.0029 0.0119 0.0722
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.017 0.0189
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0033 0.0032
Echinococcus multilocularis dna polymerase kappa 0.002 0.0065 0.0072
Schistosoma mansoni polycystin 1-related 0.002 0.0062 0.0064
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Echinococcus multilocularis neuropeptide Y receptor 0.0229 0.1357 0.1512
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Brugia malayi GnHR receptor homolog 0.0229 0.1357 0.1512
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0221 0.2322
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0018 0.0026
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0036 0.004
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0165 0.0417
Loa Loa (eye worm) acetyltransferase 0.0154 0.0892 0.0994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0163 0.1062
Schistosoma mansoni lipoxygenase 0.0084 0.0457 0.0505
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1456 0.8971 1
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0036 0.0433
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0018 0.0014
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0033 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0128 0.0137
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0352 0.0905
Echinococcus multilocularis serotonin receptor 0.1455 0.8966 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0108 0.0119
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0229 0.1357 0.1512
Echinococcus multilocularis orexin receptor type 2 0.0229 0.1357 0.1512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0091 0.0547
Onchocerca volvulus Neuropeptide F receptor homolog 0.0229 0.1357 0.9557
Echinococcus granulosus g protein coupled receptor 0.0229 0.1357 0.1356
Echinococcus multilocularis neuropeptides capa receptor 0.0229 0.1357 0.1512
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.006 0.0066
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0036 0.0035
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0028 0.0031
Loa Loa (eye worm) melatonin receptor type 1A 0.0229 0.1357 0.1512
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0065 0.0157
Trypanosoma cruzi cytochrome P450, putative 0.002 0.006 0.0062
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0018 0.0017
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0028 0.0031
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0229 0.1357 0.1512
Echinococcus granulosus rhodopsin orphan GPCR 0.0229 0.1357 0.1356
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0029 0.0032
Loa Loa (eye worm) hypothetical protein 0.1455 0.8966 0.9995
Loa Loa (eye worm) G-protein coupled receptor 0.0229 0.1357 0.1512
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0065 0.0067
Brugia malayi G protein-coupled receptor 0.0229 0.1357 0.1512
Echinococcus granulosus single minded 2 0.004 0.0186 0.0185
Echinococcus multilocularis conserved hypothetical protein 0.1393 0.8581 0.9571
Brugia malayi hypothetical protein 0.0229 0.1357 0.1512
Echinococcus granulosus 7TM GPCR rhodopsin 0.0229 0.1357 0.1356
Schistosoma mansoni single-minded 0.0049 0.0244 0.0267
Trichomonas vaginalis clathrin coat assembly protein ap19, putative 0.0129 0.0736 0.5141
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0229 0.1357 0.1512
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0018 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0229 0.1357 0.1356
Loa Loa (eye worm) CYP4Cod1 0.002 0.006 0.0066
Onchocerca volvulus 0.0229 0.1357 0.9557
Loa Loa (eye worm) hypothetical protein 0.0744 0.4555 0.5077
Schistosoma mansoni netrin receptor unc5 0.0015 0.0028 0.0026
Echinococcus granulosus fmrfamide receptor 0.0229 0.1357 0.1356
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0033 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0229 0.1357 0.1512
Echinococcus granulosus cpg binding protein 0.0031 0.0129 0.0128
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0229 0.1357 0.1509
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0322 0.1935 0.2156
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0229 0.1357 0.1512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0148 0.0958
Schistosoma mansoni histamine h1 receptor 0.0229 0.1357 0.1509
Brugia malayi Dopamine receptor protein 1 0.0649 0.3963 0.4417
Brugia malayi isocitrate dehydrogenase 0.0016 0.0036 0.0041
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0036 0.0433
Onchocerca volvulus 0.0027 0.0108 0.0643
Echinococcus multilocularis dro:myosuppressin receptor 0.0229 0.1357 0.1512
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0013 0.0018 0.0026
Schistosoma mansoni neuropeptide F-like receptor 0.0229 0.1357 0.1509
Loa Loa (eye worm) clathrin adaptor complex small chain 0.0129 0.0736 0.0819
Schistosoma mansoni hypothetical protein 0.0229 0.1357 0.1509
Brugia malayi G protein-coupled receptor F59B2.13 0.0229 0.1357 0.1512
Loa Loa (eye worm) hypothetical protein 0.1455 0.8966 0.9995
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0033 0.0135
Giardia lamblia Sigma adaptin 0.0129 0.0736 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0229 0.1357 0.1356
Schistosoma mansoni microtubule-associated protein tau 0.0758 0.4638 0.5171
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0018 0.0019
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0005 0.0005
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0163 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0148 0.0958
Onchocerca volvulus 0.002 0.0062 0.0318
Brugia malayi hypothetical protein 0.002 0.0062 0.0069
Echinococcus multilocularis g protein coupled receptor 0.0229 0.1357 0.1512
Echinococcus multilocularis G protein coupled receptor 139 0.0229 0.1357 0.1512
Schistosoma mansoni hypothetical protein 0.0011 0.0009 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0148 0.0958
Leishmania major cytochrome p450-like protein 0.002 0.006 0.0062
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0068
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0628 0.3837 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0229 0.1357 0.1356
Loa Loa (eye worm) hypothetical protein 0.0032 0.0139 0.0155
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0229 0.1357 0.1356
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0229 0.1357 0.1512
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0065 0.0364
Echinococcus granulosus serotonin receptor 0.0229 0.1357 0.1356
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0221 0.1474
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0229 0.1357 0.1509
Echinococcus granulosus tumor protein p63 0.0343 0.2065 0.2064
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0018 0.0014
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.017 0.019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0229 0.1357 0.1509
Echinococcus granulosus dro:myosuppressin receptor 0.0229 0.1357 0.1356
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0229 0.1357 0.1512
Schistosoma mansoni amine GPCR 0.0229 0.1357 0.1509
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0072 0.0075
Echinococcus multilocularis rhodopsin orphan GPCR 0.0229 0.1357 0.1512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0107 0.0663
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0128 0.1685
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0026 0.0023
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0119 0.0132
Brugia malayi putative neuropeptide receptor NPR1 0.0229 0.1357 0.1512
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0062 0.0068
Echinococcus granulosus nuclear factor of activated T cells 5 0.0075 0.0401 0.0401
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0352 0.0391
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0221 0.0245
Brugia malayi hypothetical protein 0.0229 0.1357 0.1512
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0229 0.1357 0.1509
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0219 0.2605
Schistosoma mansoni lamin 0.0027 0.0108 0.0115
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0148 0.1964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0179 0.1179
Leishmania major DNA polymerase eta, putative 0.002 0.0065 0.0067
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Onchocerca volvulus 0.0229 0.1357 0.9557
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0021
Brugia malayi Cytochrome P450 family protein 0.0011 0.0005 0.0005
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0036 0.0041
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0352 0.0387
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.002 0.0019
Brugia malayi hypothetical protein 0.0229 0.1357 0.1512
Echinococcus granulosus tachykinin peptides receptor 99D 0.0229 0.1357 0.1356
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0065 0.0072
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.002 0.0021
Brugia malayi hypothetical protein 0.0229 0.1357 0.1512
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0219 0.0218
Brugia malayi larval opioid receptor 0.0229 0.1357 0.1512
Schistosoma mansoni hypothetical protein 0.002 0.0062 0.0064
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0165 0.0183
Loa Loa (eye worm) hypothetical protein 0.005 0.0249 0.0277
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0075 0.0401 0.0447
Brugia malayi Serotonin receptor 0.0229 0.1357 0.1512
Brugia malayi hypothetical protein 0.0166 0.0965 0.1076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0031
Echinococcus granulosus rhodopsin orphan GPCR 0.0229 0.1357 0.1356
Schistosoma mansoni intermediate filament proteins 0.0027 0.0108 0.0115
Echinococcus granulosus neuropeptide FF receptor 2 0.0229 0.1357 0.1356
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0055 0.0057
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0018 0.0017
Brugia malayi neuropeptide F receptor 0.0229 0.1357 0.1512
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0072
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0005 0.0004
Leishmania major C-8 sterol isomerase-like protein 0.1456 0.8971 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0036 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0163 0.1062
Schistosoma mansoni opsin-like receptor 0.0229 0.1357 0.1509
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0065 0.0067
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0036 0.004
Brugia malayi Cytochrome P450 family protein 0.0011 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0033 0.0135
Loa Loa (eye worm) G-protein coupled receptor 0.0229 0.1357 0.1512
Echinococcus multilocularis g protein coupled receptor 0.0229 0.1357 0.1512
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0013 0.0018 0.0026
Brugia malayi Pre-SET motif family protein 0.0031 0.0128 0.0143
Schistosoma mansoni lamin 0.0027 0.0108 0.0115
Echinococcus multilocularis clathrin coat assembly protein ap17 0.0129 0.0736 0.082
Trypanosoma cruzi clathrin coat assembly protein AP17, putative 0.0129 0.0736 0.0815
Echinococcus granulosus peptide allatostatin:somatostatin 0.0229 0.1357 0.1356
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0009 0.0009
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0244 0.0267
Onchocerca volvulus 0.0229 0.1357 0.9557
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0065 0.0157
Echinococcus multilocularis neuropeptide receptor 0.0229 0.1357 0.1512
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0229 0.1357 0.1509
Schistosoma mansoni lipoxygenase 0.012 0.068 0.0754
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Echinococcus multilocularis lamin 0.0027 0.0108 0.0119
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0065 0.0067
Leishmania major DNA polymerase kappa, putative 0.002 0.0065 0.0067
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0229 0.1357 0.1356
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0229 0.1357 0.1509
Mycobacterium leprae Possible regulatory protein 0.0013 0.0018 1
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Onchocerca volvulus 0.005 0.0249 0.1654
Schistosoma mansoni neuropeptide f receptor 76f 0.0229 0.1357 0.1509
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0163 0.0177
Brugia malayi cytochrome P450 0.0011 0.0005 0.0005
Schistosoma mansoni amine GPCR 0.0229 0.1357 0.1509
Schistosoma mansoni clathrin coat assembly protein AP17 0.0129 0.0736 0.0816
Schistosoma mansoni hypothetical protein 0.0415 0.2512 0.2798
Loa Loa (eye worm) cytochrome P450 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0166 0.0965 0.1075
Schistosoma mansoni hypothetical protein 0.0229 0.1357 0.1509
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.1239 0.138
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0033 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.009 0.0546
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0229 0.1357 0.1512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0163 0.1062
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0065 0.0157
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0122 0.0767
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0352 0.0387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0091 0.0547
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0229 0.1357 0.1509
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0148 0.0958
Brugia malayi CXXC zinc finger family protein 0.0029 0.0119 0.0132
Trypanosoma brucei unspecified product 0.002 0.0065 0.0067
Schistosoma mansoni hypothetical protein 0.0229 0.1357 0.1509
Trypanosoma brucei C-8 sterol isomerase, putative 0.1456 0.8971 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0221 0.0241
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0229 0.1357 0.1356
Echinococcus granulosus arachidonate 5 lipoxygenase 0.012 0.068 0.068
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0163 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0107 0.0663
Brugia malayi hypothetical protein 0.0229 0.1357 0.1512
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0229 0.1357 0.1512
Echinococcus granulosus death domain containing protein 0.0015 0.0028 0.0028
Echinococcus granulosus somatostatin receptor 0.0229 0.1357 0.1356
Echinococcus multilocularis fmrfamide receptor 0.0229 0.1357 0.1512
Onchocerca volvulus 0.0229 0.1357 0.9557
Leishmania major protein kinase, putative 0.0018 0.0048 0.0048
Echinococcus multilocularis dnaJ subfamily B 0.0415 0.2512 0.2801
Trichomonas vaginalis clathrin coat assembly protein ap17, putative 0.0129 0.0736 0.5141
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.012 0.068 0.0758
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.0067
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0219 0.2925
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0221 0.0241
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Plasmodium falciparum AP-2 complex subunit sigma, putative 0.0129 0.0736 1
Trypanosoma brucei unspecified product 0.0014 0.0026 0.0023
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0128 0.0127
Brugia malayi Dopamine receptor protein 2 0.0229 0.1357 0.1512
Echinococcus multilocularis Ankyrin 0.0015 0.0029 0.0032
Echinococcus granulosus lamin 0.0027 0.0108 0.0107
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Brugia malayi ORL1-like opioid receptor 0.0229 0.1357 0.1512
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0191 0.0208
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.0067
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0229 0.1357 0.1512
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0229 0.1357 0.1512
Schistosoma mansoni neuropeptide F-like receptor 0.0229 0.1357 0.1509
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Loa Loa (eye worm) hypothetical protein 0.0027 0.0105 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0091 0.0547
Toxoplasma gondii AP-2 complex subunit sigma-1, putative 0.0129 0.0736 1
Echinococcus multilocularis musashi 0.0027 0.0108 0.0119
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0229 0.1357 0.1512
Onchocerca volvulus 0.0229 0.1357 0.9557
Schistosoma mansoni biogenic amine receptor 0.0229 0.1357 0.1509
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0005 0.0005
Echinococcus granulosus neuropeptides capa receptor 0.0229 0.1357 0.1356
Echinococcus granulosus Ankyrin 0.0015 0.0029 0.0028
Trypanosoma cruzi cytochrome P450, putative 0.002 0.006 0.0062
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0311 0.4184
Brugia malayi Uncoordinated protein 44 0.0015 0.0028 0.0032
Leishmania major hypothetical protein, conserved 0.0026 0.0097 0.0102
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0018 0.0014
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0229 0.1357 0.1509
Echinococcus multilocularis g-protein coupled receptor 0.0229 0.1357 0.1512
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0108 0.0119
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0062 0.0068
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0062 0.0061
Echinococcus granulosus 7tm_1 domain containing protein 0.0229 0.1357 0.1356
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0128 0.0811
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.0892 0.0995
Echinococcus granulosus neuropeptide receptor 0.0229 0.1357 0.1356
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0036 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0128 0.0137
Echinococcus granulosus tm gpcr rhodopsin 0.0229 0.1357 0.1356
Onchocerca volvulus 0.0229 0.1357 0.9557
Echinococcus granulosus neuropeptide receptor A26 0.0229 0.1357 0.1356
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0195 0.2271
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Onchocerca volvulus 0.0229 0.1357 0.9557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0163 0.1062
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0068
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0018
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0065 0.0067
Echinococcus multilocularis neuropeptide Y receptor 0.0229 0.1357 0.1512
Trichomonas vaginalis adenylate cyclase, putative 0.0013 0.0018 0.0026
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0195 0.1941
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0097 0.0861
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0028 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0091 0.0547
Echinococcus granulosus dna polymerase eta 0.002 0.0065 0.0064
Onchocerca volvulus 0.0229 0.1357 0.9557
Echinococcus multilocularis g protein coupled receptor 0.0229 0.1357 0.1512
Schistosoma mansoni neuropeptide receptor 0.0229 0.1357 0.1509
Echinococcus multilocularis neuropeptide receptor A26 0.0229 0.1357 0.1512
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0029 0.0027
Schistosoma mansoni biogenic amine receptor 0.0229 0.1357 0.1509
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.0067
Brugia malayi hypothetical protein 0.0026 0.0097 0.0108
Schistosoma mansoni hypothetical protein 0.0229 0.1357 0.1509
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.017 0.0169
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0229 0.1357 0.1509
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0097 0.0861
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.0892 0.0994
Loa Loa (eye worm) neuropeptide F receptor 0.0229 0.1357 0.1512
Echinococcus multilocularis rhodopsin orphan GPCR 0.0229 0.1357 0.1512
Echinococcus multilocularis lamin dm0 0.0027 0.0108 0.0119
Echinococcus granulosus RUN 0.002 0.0062 0.0061
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0005 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0221 0.1474
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0229 0.1357 0.1512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0163 0.1062
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0097 0.0861
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0229 0.1357 0.1509
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0117 0.0116
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0028 0.0028
Brugia malayi hypothetical protein 0.0123 0.0704 0.0785
Echinococcus multilocularis neuropeptide FF receptor 2 0.0229 0.1357 0.1512
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0065 0.0364
Plasmodium vivax AP-2 complex subunit sigma, putative 0.0129 0.0736 1
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0352 0.4744
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0229 0.1357 0.1509
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.017 0.0189
Echinococcus granulosus dnaJ subfamily B 0.0415 0.2512 0.2512
Brugia malayi Tachykinin-like peptides receptor 99D 0.0229 0.1357 0.1512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.009 0.0546
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0221 0.0241
Onchocerca volvulus 0.0229 0.1357 0.9557
Entamoeba histolytica clathrin adaptor complex small chain, putative 0.0129 0.0736 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0065 0.0067
Echinococcus granulosus neuropeptide receptor 0.0229 0.1357 0.1356
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0229 0.1357 0.1356
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0033 0.0037
Brugia malayi hypothetical protein 0.0229 0.1357 0.1512
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0065 0.0067
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0065 0.0072
Trichomonas vaginalis clathrin coat assembly protein ap19, putative 0.0129 0.0736 0.5141
Schistosoma mansoni cpg binding protein 0.0031 0.0129 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0026 0.0023
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0065 0.0064
Schistosoma mansoni hypothetical protein 0.0015 0.0028 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0018 0.0026
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0165 0.0183
Echinococcus multilocularis microtubule associated protein 2 0.0758 0.4638 0.5173
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0229 0.1357 0.1512
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Brugia malayi hypothetical protein 0.0229 0.1357 0.1512
Echinococcus granulosus g-protein coupled receptor 0.0229 0.1357 0.1356
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0018 0.0026
Echinococcus granulosus orexin receptor type 2 0.0229 0.1357 0.1356
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0018
Brugia malayi hypoxia-induced factor 1 0.0153 0.0886 0.0987
Loa Loa (eye worm) TYRA-2 protein 0.0229 0.1357 0.1512
Schistosoma mansoni amine GPCR 0.0229 0.1357 0.1509
Schistosoma mansoni cpg binding protein 0.0029 0.0119 0.0127
Echinococcus multilocularis fmrfamide receptor 0.0229 0.1357 0.1512
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0065 0.0072
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0065 0.0067
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Onchocerca volvulus 0.0229 0.1357 0.9557
Echinococcus multilocularis rhodopsin orphan GPCR 0.0229 0.1357 0.1512
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0219 0.2925
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0219 0.1458
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0018 0.0026
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Brugia malayi Melatonin receptor type 1A 0.0229 0.1357 0.1512
Echinococcus granulosus G protein coupled receptor 139 0.0229 0.1357 0.1356
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Brugia malayi hypothetical protein 0.002 0.0062 0.0069
Echinococcus granulosus neuropeptide Y receptor 0.0229 0.1357 0.1356
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0029 0.0031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0352 0.0905
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0032
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0097 0.0102
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0628 0.3837 1
Brugia malayi Pre-SET motif family protein 0.021 0.1239 0.1381
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0018 0.0019
Onchocerca volvulus 0.0031 0.0128 0.0788
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0018 0.0014
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0229 0.1357 0.1509
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0229 0.1357 0.1509
Schistosoma mansoni loxhd1 0.002 0.0062 0.0064
Echinococcus granulosus allatostatin A receptor 0.0229 0.1357 0.1356
Schistosoma mansoni adenoreceptor 0.0229 0.1357 0.1509
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0107 0.0663
Schistosoma mansoni cpg binding protein 0.0031 0.0129 0.0139
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0108 0.012
Echinococcus granulosus histone acetyltransferase KAT2B 0.0149 0.0866 0.0865
Schistosoma mansoni rab6-interacting 0.002 0.0062 0.0064
Echinococcus granulosus g protein coupled receptor 0.0229 0.1357 0.1356
Echinococcus granulosus tm gpcr rhodopsin 0.0229 0.1357 0.1356
Echinococcus granulosus intermediate filament protein 0.0027 0.0108 0.0107
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0108 0.0119
Plasmodium vivax SET domain protein, putative 0.0031 0.0128 0.1309
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0036 0.0035
Loa Loa (eye worm) doublecortin family protein 0.002 0.0062 0.0068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0229 0.1357 0.1509
Onchocerca volvulus 0.0229 0.1357 0.9557
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0352 0.0387
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Loa Loa (eye worm) hypothetical protein 0.0026 0.0097 0.0107
Echinococcus granulosus clathrin coat assembly protein ap17 0.0129 0.0736 0.0735
Schistosoma mansoni amine GPCR 0.1218 0.7496 0.8359
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0229 0.1357 0.1512
Leishmania major protein kinase, putative 0.0013 0.0018 0.0014
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0033 0.0031
Onchocerca volvulus 0.0229 0.1357 0.9557
Schistosoma mansoni neuropeptide receptor 0.0229 0.1357 0.1509
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.009 0.0546
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0105 0.0651
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0128 0.0142
Schistosoma mansoni rab6-interacting 0.002 0.0062 0.0064
Loa Loa (eye worm) hypothetical protein 0.0229 0.1357 0.1512
Echinococcus granulosus rhodopsin orphan GPCR 0.0229 0.1357 0.1356
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0221 0.0241
Echinococcus multilocularis rhodopsin orphan GPCR 0.0229 0.1357 0.1512

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 55 nM Inhibitory activity against Melanin-concentrating hormone receptor 1 ChEMBL. 15225734
IC50 (binding) = 58 nM Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cells ChEMBL. 16134937
IC50 (binding) = 58 nM Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cells ChEMBL. 16134937
IC50 (binding) = 71 nM Tested for MCH-1 induced [Ca2+] release from CHO cells transfected with human MCH-1R ChEMBL. 15225734
IC50 (binding) = 71 nM Tested for MCH-1 induced [Ca2+] release from CHO cells transfected with human MCH-1R ChEMBL. 15225734
IC50 (binding) = 349 nM Inhibitory activity against human 5-HT2B receptor ChEMBL. 15225734
IC50 (binding) = 349 nM Inhibitory activity against human 5-HT2B receptor ChEMBL. 15225734
IC50 (binding) = 970 nM Inhibitory activity against human 5-HT2C receptor ChEMBL. 15225734
IC50 (binding) = 970 nM Inhibitory activity against human 5-HT2C receptor ChEMBL. 15225734
IC50 (binding) = 2180 nM Inhibitory activity against human 5-HT2A receptor ChEMBL. 15225734
IC50 (binding) = 2180 nM Inhibitory activity against human 5-HT2A receptor ChEMBL. 15225734
IC50 (binding) = 0.05 uM Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cells ChEMBL. 15267235
IC50 (binding) = 0.05 uM Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cells ChEMBL. 15267235
Inhibition (binding) = 35 % Inhibitory activity against human D2 receptor at 10 uM ChEMBL. 15225734
Inhibition (binding) = 35 % Inhibitory activity against human D2 receptor at 10 uM ChEMBL. 15225734
Inhibition (binding) = 84 % Inhibitory activity against human adrenergic alpha1A receptor at 10 uM ChEMBL. 15225734
Inhibition (binding) = 84 % Inhibitory activity against human adrenergic alpha1A receptor at 10 uM ChEMBL. 15225734
Ratio (binding) = 6 Selectivity ratio for MCH-1R versus 5-HT2B receptor ChEMBL. 15225734

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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