Detailed information for compound 328036

Basic information

Technical information
  • TDR Targets ID: 328036
  • Name: [1-[(3-phenyl-1,2,4-thiadiazol-5-yl)oxymethyl ]cyclobutyl]methyl N-[(3S)-1,2-dioxo-1-[[(1R) -1-phenylethyl]amino]heptan-3-yl]carbamate
  • MW: 564.696 | Formula: C30H36N4O5S
  • H donors: 2 H acceptors: 5 LogP: 6.53 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCC[C@@H](C(=O)C(=O)N[C@@H](c1ccccc1)C)NC(=O)OCC1(CCC1)COc1snc(n1)c1ccccc1
  • InChi: 1S/C30H36N4O5S/c1-3-4-16-24(25(35)27(36)31-21(2)22-12-7-5-8-13-22)32-28(37)38-19-30(17-11-18-30)20-39-29-33-26(34-40-29)23-14-9-6-10-15-23/h5-10,12-15,21,24H,3-4,11,16-20H2,1-2H3,(H,31,36)(H,32,37)/t21-,24+/m1/s1
  • InChiKey: YEJBZKQTALZTBW-QPPBQGQZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [1-[(3-phenyl-1,2,4-thiadiazol-5-yl)oxymethyl]cyclobutyl]methyl N-[(1S)-1-[2-oxo-2-[[(1R)-1-phenylethyl]amino]acetyl]pentyl]carbamate
  • N-[(1S)-1-[1,2-dioxo-2-[[(1R)-1-phenylethyl]amino]ethyl]pentyl]carbamic acid [1-[(3-phenyl-1,2,4-thiadiazol-5-yl)oxymethyl]cyclobutyl]methyl ester
  • N-[(1S)-1-[2-keto-2-[[(1R)-1-phenylethyl]amino]acetyl]pentyl]carbamic acid [1-[(3-phenyl-1,2,4-thiadiazol-5-yl)oxymethyl]cyclobutyl]methyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin K Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis gamma secretase subunit aph 1 0.0238 0.0498 0.039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0308 0.0737 0.2319
Echinococcus granulosus cathepsin l1 0.0308 0.0737 0.0633
Plasmodium vivax vivapain-3 0.0202 0.0374 0.1039
Trypanosoma brucei calpain-like protein, putative 0.0861 0.2637 0.8292
Toxoplasma gondii calcium-dependent protein kinase 0.0127 0.0116 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0308 0.0737 0.204
Echinococcus multilocularis calbindin 32 0.0127 0.0116 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0202 0.0374 0.1176
Loa Loa (eye worm) fibroinase 0.0308 0.0737 0.0633
Trypanosoma brucei calpain-like protein, putative 0.0861 0.2637 0.8292
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0308 0.0737 0.204
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.136
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0129 0.0126 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0308 0.0737 0.204
Onchocerca volvulus 0.0308 0.0737 0.1376
Entamoeba histolytica cysteine protease, putative 0.0202 0.0374 0.1563
Plasmodium falciparum serine repeat antigen 4 0.0129 0.0126 0.0232
Echinococcus granulosus cathepsin l cysteine peptidase 0.0308 0.0737 0.0633
Trypanosoma brucei calpain-like protein, putative 0.0861 0.2637 0.8292
Echinococcus multilocularis EF hand domain containing family member A2 0.0127 0.0116 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0308 0.0737 0.2319
Brugia malayi Papain family cysteine protease containing protein 0.0129 0.0126 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0308 0.0737 0.204
Giardia lamblia Cathepsin B precursor 0.102 0.318 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0861 0.2637 0.2637
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0308 0.0737 0.204
Schistosoma mansoni hypothetical protein 0.0247 0.0529 0.0422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0308 0.0737 0.204
Entamoeba histolytica cysteine protease, putative 0.0202 0.0374 0.1563
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0247 0.0529 0.0529
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0129 0.0126 0.0047
Echinococcus multilocularis hypothetical protein 0.0861 0.2637 0.2554
Brugia malayi Cathepsin L-like precursor 0.0235 0.049 0.0382
Onchocerca volvulus 0.0127 0.0116 0.0011
Schistosoma mansoni cathepsin F (C01 family) 0.0308 0.0737 0.0633
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0129 0.0126 0.0232
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.0529
Trichomonas vaginalis calcineurin B subunit, putative 0.0127 0.0116 0.0016
Trichomonas vaginalis calmodulin, putative 0.0133 0.0138 0.0085
Trypanosoma cruzi kinesin, putative 0.0615 0.179 0.179
Leishmania major cathepsin L-like protease 0.0308 0.0737 0.204
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0861 0.2637 0.8292
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0125 0.0112 0.0112
Loa Loa (eye worm) cysteine protease 0.0308 0.0737 0.0633
Entamoeba histolytica grainin 2 0.0133 0.0138 0.0155
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.1663
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0308 0.0737 0.204
Echinococcus multilocularis cathepsin L cysteine protease 0.0308 0.0737 0.0633
Echinococcus granulosus calpain A 0.0861 0.2637 0.2554
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2312 0.7613 0.7586
Leishmania major cathepsin L-like protease 0.0308 0.0737 0.204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.0126 0.0047
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.0529
Plasmodium falciparum serine repeat antigen 1 0.0129 0.0126 0.0232
Echinococcus multilocularis calpain family protein 1, d 0.1697 0.5505 0.5454
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0861 0.2637 0.2637
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0129 0.0126 0.0015
Plasmodium falciparum serine repeat antigen 8 0.0129 0.0126 0.0232
Brugia malayi Cathepsin L-like precursor 0.0308 0.0737 0.0633
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.136
Entamoeba histolytica hypothetical protein 0.0129 0.0126 0.0087
Loa Loa (eye worm) calpain family protein 1 0.1697 0.5505 0.5454
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0129 0.0126 0.0232
Giardia lamblia Cathepsin L-like protease 0.0129 0.0126 0.0032
Trichomonas vaginalis calpain, putative 0.0247 0.0529 0.136
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.136
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0247 0.0529 0.0529
Entamoeba histolytica cysteine proteinase, putative 0.0202 0.0374 0.1563
Brugia malayi gamma-secretase subunit aph-1 0.0238 0.0498 0.039
Echinococcus multilocularis cathepsin b 0.3008 1 1
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0125 0.0112 0.0112
Giardia lamblia Cysteine protease 0.0129 0.0126 0.0032
Giardia lamblia Cathepsin B precursor 0.0129 0.0126 0.0032
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0861 0.2637 0.8292
Echinococcus multilocularis calpain 5 0.0861 0.2637 0.2554
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.0529
Trypanosoma cruzi cysteine peptidase, putative 0.0308 0.0737 0.0737
Entamoeba histolytica cysteine protease, putative 0.0202 0.0374 0.1563
Trichomonas vaginalis calpain, putative 0.0247 0.0529 0.136
Trypanosoma cruzi centrin-3 0.0133 0.0138 0.0138
Schistosoma mansoni cathepsin C 0.0129 0.0126 0.0015
Onchocerca volvulus 0.0308 0.0737 0.1376
Plasmodium falciparum serine repeat antigen 6 0.0129 0.0126 0.0232
Echinococcus granulosus calumenin 0.0127 0.0116 0.0005
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3008 1 1
Entamoeba histolytica grainin, putative 0.0127 0.0116 0.0029
Leishmania major hypothetical protein, unknown function 0.0247 0.0529 0.136
Trypanosoma brucei centrin, putative 0.0125 0.0112 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.0126 0.0047
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0247 0.0529 0.0529
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.0529
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0129 0.0126 0.0058
Entamoeba histolytica cysteine protease, putative 0.0202 0.0374 0.1563
Entamoeba histolytica cysteine protease, putative 0.0308 0.0737 0.3728
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.136
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0202 0.0374 0.0265
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0129 0.0126 0.0232
Giardia lamblia Cathepsin B precursor 0.0129 0.0126 0.0032
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0129 0.0126 0.0058
Toxoplasma gondii hypothetical protein 0.0247 0.0529 0.136
Leishmania major cathepsin L-like protease 0.0308 0.0737 0.204
Loa Loa (eye worm) hypothetical protein 0.0129 0.0126 0.0015
Trypanosoma cruzi prolyl endopeptidase 0.0126 0.0116 0.0116
Trypanosoma cruzi I/6 autoantigen, putative 0.0125 0.0112 0.0112
Brugia malayi Cathepsin L-like precursor 0.0308 0.0737 0.0633
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0861 0.2637 0.823
Entamoeba histolytica cysteine proteinase 2 0.0202 0.0374 0.1563
Plasmodium falciparum cysteine proteinase falcipain 1 0.0202 0.0374 0.4192
Echinococcus granulosus cathepsin L 0.0202 0.0374 0.0265
Echinococcus granulosus cysteine protease 0.0202 0.0374 0.0265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0308 0.0737 0.204
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0247 0.0529 0.0529
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.136
Leishmania major kinesin, putative 0.0615 0.179 0.5471
Giardia lamblia Cathepsin L precursor 0.0129 0.0126 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0308 0.0737 0.2319
Onchocerca volvulus Cathepsin L homolog 0.0129 0.0126 0.0032
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0129 0.0126 0.0058
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.136
Entamoeba histolytica cysteine protease, putative 0.0129 0.0126 0.0087
Onchocerca volvulus Cathepsin L homolog 0.0308 0.0737 0.1376
Schistosoma mansoni Mername-AA248 (C02 family) 0.0861 0.2637 0.2554
Entamoeba histolytica cysteine proteinase, putative 0.0308 0.0737 0.3728
Brugia malayi prolyl oligopeptidase family protein 0.0126 0.0116 0.0005
Giardia lamblia Cathepsin B precursor 0.0129 0.0126 0.0032
Leishmania major hypothetical protein, conserved 0.0127 0.0116 0.0016
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0308 0.0737 0.0633
Entamoeba histolytica calpain family cysteine protease, putative 0.0247 0.0529 0.2485
Loa Loa (eye worm) hypothetical protein 0.0129 0.0126 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0308 0.0737 0.2319
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0126 0.0116 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0308 0.0737 0.204
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0861 0.2637 0.2637
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0247 0.0529 0.136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0308 0.0737 0.204
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0129 0.0126 0.0047
Echinococcus multilocularis calumenin 0.0127 0.0116 0.0005
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0125 0.0112 0.0112
Onchocerca volvulus 0.0235 0.049 0.0831
Schistosoma mansoni calpain-7 (C02 family) 0.0861 0.2637 0.2554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0308 0.0737 0.204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.0126 0.0047
Trichomonas vaginalis calmodulin, putative 0.0127 0.0116 0.0016
Trypanosoma brucei centrin-3 0.0133 0.0138 0.0433
Trypanosoma cruzi major cysteine proteinase, putative 0.0129 0.0126 0.0126
Echinococcus multilocularis cathepsin L 0.0202 0.0374 0.0265
Onchocerca volvulus 0.0308 0.0737 0.1376
Loa Loa (eye worm) hypothetical protein 0.0129 0.0126 0.0015
Entamoeba histolytica cysteine protease, putative 0.0202 0.0374 0.1563
Entamoeba histolytica cysteine protease, putative 0.0202 0.0374 0.1563
Loa Loa (eye worm) calpain 5 0.0615 0.179 0.1698
Schistosoma mansoni cathepsin B (C01 family) 0.0129 0.0126 0.0015
Plasmodium vivax serine-repeat antigen (SERA) 0.0129 0.0126 0.0058
Plasmodium falciparum serine repeat antigen 2 0.0129 0.0126 0.0232
Brugia malayi cathepsin Z-like cysteine proteinase 0.0129 0.0126 0.0015
Entamoeba histolytica cysteine protease, putative 0.0129 0.0126 0.0087
Trypanosoma brucei Calpain-like protein 1.1 0.0247 0.0529 0.1663
Brugia malayi Cathepsin L-like precursor 0.0308 0.0737 0.0633
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0247 0.0529 0.0529
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0308 0.0737 0.2319
Brugia malayi Papain family cysteine protease containing protein 0.0202 0.0374 0.0265
Trypanosoma brucei I/6 autoantigen 0.0125 0.0112 0.0351
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.136
Loa Loa (eye worm) hypothetical protein 0.2312 0.7613 0.7586
Loa Loa (eye worm) calpain family protein 1 0.2312 0.7613 0.7586
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0129 0.0126 0.0058
Trypanosoma brucei calmodulin, putative 0.0125 0.0112 0.0351
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0308 0.0737 0.2319
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0861 0.2637 0.2637
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.136
Echinococcus granulosus gamma secretase subunit aph 1 0.0238 0.0498 0.039
Entamoeba histolytica cysteine proteinase 1, putative 0.0202 0.0374 0.1563
Trypanosoma brucei calpain-like protein, putative 0.0861 0.2637 0.8292
Schistosoma mansoni calpain-7 (C02 family) 0.0861 0.2637 0.2554
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0308 0.0737 0.2319
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0308 0.0737 0.0633
Plasmodium falciparum serine repeat antigen 7 0.0129 0.0126 0.0232
Loa Loa (eye worm) hypothetical protein 0.0129 0.0126 0.0015
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0129 0.0126 0.0032
Brugia malayi Cathepsin L-like precursor 0.0308 0.0737 0.0633
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.2437 0.8042 0.802
Schistosoma mansoni calpain (C02 family) 0.0861 0.2637 0.2554
Brugia malayi cathepsin L-like cysteine proteinase 0.0129 0.0126 0.0015
Loa Loa (eye worm) ctsf protein 0.0308 0.0737 0.0633
Onchocerca volvulus 0.0308 0.0737 0.1376
Trypanosoma brucei mitochondrial calcium uptake 1 0.0125 0.0112 0.0351
Plasmodium falciparum serine repeat antigen 5 0.0129 0.0126 0.0232
Trypanosoma brucei calpain, putative 0.0247 0.0529 0.1663
Trichomonas vaginalis calcium binding protein, putative 0.0133 0.0138 0.0085
Loa Loa (eye worm) hypothetical protein 0.1697 0.5505 0.5454
Entamoeba histolytica cysteine proteinase, putative 0.0308 0.0737 0.3728
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0247 0.0529 0.1663
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0126 0.0116 0.0005
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0861 0.2637 0.2637
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.0126 0.0047
Trypanosoma brucei centrin, putative 0.0125 0.0112 0.0351
Brugia malayi cathepsin L precursor 0.0129 0.0126 0.0015
Echinococcus multilocularis cathepsin L cysteine protease 0.0308 0.0737 0.0633
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0247 0.0529 0.136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0129 0.0126 0.0047
Trypanosoma brucei Calpain-like protein 1.2 0.0247 0.0529 0.1663
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2437 0.8042 0.802
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0308 0.0737 0.0633
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0129 0.0126 0.0058
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0247 0.0529 0.136
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0247 0.0529 0.136
Schistosoma mansoni reticulocalbin 0.0127 0.0116 0.0005
Brugia malayi calpain 5 0.0615 0.179 0.1698
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.136
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0126 0.0116 0.0005
Leishmania major cathepsin L-like protease 0.0308 0.0737 0.204
Trypanosoma cruzi cysteine proteinase, putative 0.0202 0.0374 0.0374
Echinococcus multilocularis cathepsin L 0.0129 0.0126 0.0015
Trypanosoma brucei Component of motile flagella 41 0.0125 0.0112 0.0351
Giardia lamblia Cathepsin B precursor 0.102 0.318 1
Echinococcus multilocularis calpain 0.0861 0.2637 0.2554
Giardia lamblia Cysteine protease 0.0129 0.0126 0.0032
Brugia malayi cathepsin F-like cysteine proteinase 0.0129 0.0126 0.0015
Plasmodium vivax vivapain-2 0.0308 0.0737 0.2478
Schistosoma mansoni cathepsin S (C01 family) 0.0129 0.0126 0.0015
Loa Loa (eye worm) hypothetical protein 0.0129 0.0126 0.0015
Echinococcus multilocularis programmed cell death protein 0.0133 0.0138 0.0026
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0129 0.0126 0.0015
Giardia lamblia Cathepsin B precursor 0.0129 0.0126 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0308 0.0737 0.204
Giardia lamblia Cathepsin L precursor 0.0129 0.0126 0.0032
Giardia lamblia Cathepsin B precursor 0.102 0.318 1
Brugia malayi Cathepsin L-like precursor 0.0308 0.0737 0.0633
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.0529
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0861 0.2637 0.2637
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0247 0.0529 0.136
Echinococcus granulosus calbindin 32 0.0127 0.0116 0.0005
Echinococcus multilocularis calcium uptake protein 1 0.0127 0.0116 0.0005
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0238 0.0498 0.039
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0129 0.0126 0.0047
Onchocerca volvulus Cathepsin L homolog 0.0308 0.0737 0.1376
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0129 0.0126 0.0058
Onchocerca volvulus 0.1451 0.4658 1
Echinococcus granulosus cathepsin b 0.3008 1 1
Giardia lamblia Cysteine protease 0.0129 0.0126 0.0032
Giardia lamblia Cathepsin L precursor 0.0129 0.0126 0.0032
Brugia malayi Papain family cysteine protease containing protein 0.0129 0.0126 0.0015
Echinococcus multilocularis cysteine protease 0.0308 0.0737 0.0633
Loa Loa (eye worm) cathepsin B 0.102 0.318 0.3103
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0129 0.0126 0.0047
Trypanosoma cruzi centrin, putative 0.0133 0.0138 0.0138
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0125 0.0112 0.0112
Trypanosoma cruzi calmodulin, putative 0.0125 0.0112 0.0112
Entamoeba histolytica hypothetical protein, conserved 0.0127 0.0116 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0308 0.0737 0.204
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.136
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0129 0.0126 0.0015
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0247 0.0529 0.0529
Plasmodium vivax hypothetical protein, conserved 0.0127 0.0116 0.0019
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0129 0.0126 0.0032
Echinococcus multilocularis calpain 7 (C02 family) 0.0861 0.2637 0.2554
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0247 0.0529 0.1663
Trichomonas vaginalis calpain, putative 0.0247 0.0529 0.136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.049 0.1232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0308 0.0737 0.2319
Toxoplasma gondii preprocathepsin c precursor, putative 0.0129 0.0126 0.0047
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0861 0.2637 0.2637
Echinococcus multilocularis prolyl endopeptidase 0.0126 0.0116 0.0005
Loa Loa (eye worm) calpain 0.0861 0.2637 0.2554
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.102 0.318 1
Trichomonas vaginalis conserved hypothetical protein 0.0247 0.0529 0.136
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0129 0.0126 0.0047
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0129 0.0126 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.0126 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0308 0.0737 0.2319
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0129 0.0126 0.0015
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0125 0.0112 0.0351
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.1663
Toxoplasma gondii cathepsin CPL 0.0308 0.0737 0.204
Trypanosoma cruzi cysteine protease, putative 0.0202 0.0374 0.0374
Echinococcus multilocularis cathepsin b 0.3008 1 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0129 0.0126 0.0015
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0129 0.0126 0.0058
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.136
Onchocerca volvulus Prolyl endopeptidase homolog 0.0126 0.0116 0.001
Leishmania major hypothetical protein, conserved 0.0247 0.0529 0.136
Loa Loa (eye worm) calpain D 0.0247 0.0529 0.0422
Plasmodium vivax vivapain-2 0.0308 0.0737 0.2478
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0308 0.0737 0.2319
Plasmodium falciparum serine repeat antigen 9 0.0129 0.0126 0.0232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0308 0.0737 0.204
Entamoeba histolytica cysteine protease, putative 0.0129 0.0126 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0202 0.0374 0.1176
Plasmodium falciparum serine repeat antigen 3 0.0129 0.0126 0.0232
Giardia lamblia Cathepsin L precursor 0.0129 0.0126 0.0032
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0308 0.0737 0.204
Trypanosoma cruzi centrin, putative 0.0133 0.0138 0.0138
Brugia malayi cathepsin L-like precursor 0.0235 0.049 0.0382
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0247 0.0529 0.0529
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0127 0.0116 0.0005
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0308 0.0737 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0308 0.0737 0.204
Entamoeba histolytica cysteine protease, putative 0.0202 0.0374 0.1563
Leishmania major cathepsin L-like protease 0.0308 0.0737 0.204
Brugia malayi fibroinase precursor 0.0129 0.0126 0.0015
Trypanosoma brucei protein I/6 0.0125 0.0112 0.0351
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0125 0.0112 0.0112
Giardia lamblia Encystation-specific protease 0.0129 0.0126 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0308 0.0737 0.204
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0308 0.0737 0.204
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0129 0.0126 0.0087
Echinococcus multilocularis programmed cell death protein 0.0133 0.0138 0.0026
Entamoeba histolytica cysteine protease, putative 0.0202 0.0374 0.1563
Entamoeba histolytica cysteine protease, putative 0.0202 0.0374 0.1563
Trypanosoma cruzi cysteine peptidase, putative 0.0308 0.0737 0.0737
Brugia malayi Papain family cysteine protease containing protein 0.0129 0.0126 0.0015
Toxoplasma gondii cathepsin CPC1 0.0129 0.0126 0.0047
Trypanosoma brucei calmodulin, putative 0.0127 0.0116 0.0366
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0861 0.2637 0.823
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0247 0.0529 0.0529
Trypanosoma cruzi major cysteine proteinase, putative 0.0129 0.0126 0.0126
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.102 0.318 0.318
Onchocerca volvulus 0.0308 0.0737 0.1376
Entamoeba histolytica cysteine protease, putative 0.0202 0.0374 0.1563
Trypanosoma brucei antigen, putative 0.0861 0.2637 0.8292
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0308 0.0737 0.204
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0129 0.0126 0.0032
Echinococcus granulosus calpain 5 0.0861 0.2637 0.2554
Onchocerca volvulus Cathepsin F homolog 0.0308 0.0737 0.1376
Giardia lamblia Cathepsin L precursor 0.0129 0.0126 0.0032
Echinococcus granulosus EF hand domain containing family member A2 0.0127 0.0116 0.0005
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.136
Entamoeba histolytica cysteine protease, putative 0.0129 0.0126 0.0087
Loa Loa (eye worm) hypothetical protein 0.3008 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0202 0.0374 0.0265
Brugia malayi cathepsin Z-like cysteine proteinase 0.0129 0.0126 0.0015
Brugia malayi Cathepsin L-like precursor 0.0308 0.0737 0.0633
Schistosoma mansoni calpain C (C02 family) 0.0861 0.2637 0.2554
Trypanosoma brucei hypothetical protein, conserved 0.0125 0.0112 0.0351
Trypanosoma cruzi cysteine peptidase, putative 0.0308 0.0737 0.0737
Brugia malayi Cathepsin L-like precursor 0.0235 0.049 0.0382
Toxoplasma gondii calmodulin CAM1 0.0127 0.0116 0.0016
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0247 0.0529 0.136
Echinococcus multilocularis calpain A 0.2439 0.8047 0.8025
Entamoeba histolytica cysteine protease, putative 0.0202 0.0374 0.1563
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0308 0.0737 0.204
Trichomonas vaginalis hypothetical protein 0.0247 0.0529 0.136
Echinococcus granulosus calpain 7 C02 family 0.0861 0.2637 0.2554
Trypanosoma cruzi caltractin, putative 0.0125 0.0112 0.0112
Leishmania major calpain protease-like protein 0.0247 0.0529 0.136
Loa Loa (eye worm) hypothetical protein 0.0308 0.0737 0.0633
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.0529
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0308 0.0737 0.0633
Echinococcus granulosus calpain 0.0861 0.2637 0.2554
Leishmania major cathepsin L-like protease 0.0308 0.0737 0.204
Entamoeba histolytica cysteine protease, putative 0.0202 0.0374 0.1563
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.3008 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0308 0.0737 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.1663
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.2437 0.8042 0.802
Echinococcus granulosus cathepsin L cysteine proteinase 0.0308 0.0737 0.0633
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.0529
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0129 0.0126 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0308 0.0737 0.204
Toxoplasma gondii cathepsin B 0.102 0.318 1
Echinococcus multilocularis cysteine protease 0.0308 0.0737 0.0633
Giardia lamblia Cysteine protease 0.0129 0.0126 0.0032
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0129 0.0126 0.0015
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0129 0.0126 0.0015
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.136
Echinococcus granulosus cathepsin l1 0.0235 0.049 0.0382
Toxoplasma gondii prolyl endopeptidase 0.0126 0.0116 0.0015
Trypanosoma cruzi calmodulin, putative 0.0125 0.0112 0.0112
Onchocerca volvulus 0.0308 0.0737 0.1376
Trypanosoma cruzi kinesin, putative 0.0615 0.179 0.179
Brugia malayi calpain family protein 1 0.2312 0.7613 0.7586
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0308 0.0737 0.204
Entamoeba histolytica cysteine protease, putative 0.0129 0.0126 0.0087
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0129 0.0126 0.0032
Entamoeba histolytica cysteine proteinase, putative 0.0202 0.0374 0.1563
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0202 0.0374 0.0855
Leishmania major cathepsin L-like protease 0.0308 0.0737 0.204
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0861 0.2637 0.823
Trypanosoma cruzi cysteine proteinase, putative 0.0202 0.0374 0.0374
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0202 0.0374 0.0374
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0247 0.0529 0.0529
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0129 0.0126 0.0047
Echinococcus granulosus calpain A 0.2439 0.8047 0.8025
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0861 0.2637 0.2637
Brugia malayi calpain 7 0.0861 0.2637 0.2554
Brugia malayi Papain family cysteine protease containing protein 0.0202 0.0374 0.0265
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.102 0.318 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0129 0.0126 0.0047
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0113 0.0071 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0202 0.0374 0.0374
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3008 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.0126 0.0047
Trypanosoma brucei hypothetical protein 0.0247 0.0529 0.1663
Loa Loa (eye worm) hypothetical protein 0.0247 0.0529 0.0422
Echinococcus granulosus cathepsin b 0.3008 1 1
Giardia lamblia Hypothetical protein 0.0129 0.0126 0.0032
Trypanosoma brucei prolyl endopeptidase 0.0126 0.0116 0.0365
Trypanosoma brucei Calpain-like protein 2 0.0247 0.0529 0.1663
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0202 0.0374 0.0855
Plasmodium vivax serine-repeat antigen (SERA) 0.0129 0.0126 0.0058
Loa Loa (eye worm) hypothetical protein 0.0235 0.049 0.0382
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0235 0.049 0.049
Onchocerca volvulus 0.0129 0.0126 0.0032
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.102 0.318 0.3103
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.0529
Plasmodium vivax vivapain-1 0.0202 0.0374 0.1039
Loa Loa (eye worm) hypothetical protein 0.2065 0.6766 0.673
Entamoeba histolytica cysteine proteinase, putative 0.0202 0.0374 0.1563
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0308 0.0737 0.2319
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0861 0.2637 0.2637
Loa Loa (eye worm) hypothetical protein 0.1451 0.4658 0.4598
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.3008 1 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.0116 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0308 0.0737 0.204
Echinococcus granulosus calcium uptake protein 1 0.0127 0.0116 0.0005
Trypanosoma cruzi cysteine peptidase, putative 0.0308 0.0737 0.0737
Echinococcus granulosus programmed cell death protein 0.0133 0.0138 0.0026
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0125 0.0112 0.0351
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0861 0.2637 0.2637
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0129 0.0126 0.0047
Plasmodium vivax unspecified product 0.0202 0.0374 0.1039
Giardia lamblia Hypothetical protein 0.0129 0.0126 0.0032
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0127 0.0116 0.0116
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0202 0.0374 0.0265
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0129 0.0126 0.0015
Trypanosoma cruzi I/6 autoantigen, putative 0.0125 0.0112 0.0112
Brugia malayi calpain family protein 1 0.2312 0.7613 0.7586
Plasmodium vivax calpain, putative 0.0861 0.2637 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.136
Trypanosoma cruzi calmodulin, putative 0.0125 0.0112 0.0112
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0129 0.0126 0.0015
Loa Loa (eye worm) hypothetical protein 0.0235 0.049 0.0382
Trypanosoma cruzi cruzipain precursor, putative 0.0308 0.0737 0.0737
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2437 0.8042 0.802
Echinococcus granulosus cathepsin L 0.0129 0.0126 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0308 0.0737 0.204
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0129 0.0126 0.0058
Entamoeba histolytica cysteine protease, putative 0.0202 0.0374 0.1563
Leishmania major cathepsin L-like protease 0.0308 0.0737 0.204
Leishmania major cysteine peptidase A (CPA) 0.0308 0.0737 0.204
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0247 0.0529 0.136
Trypanosoma brucei caltractin, putative 0.0133 0.0138 0.0433
Entamoeba histolytica calpain large subunit domain III containing protein 0.0615 0.179 1
Trypanosoma brucei kinesin, putative 0.0615 0.179 0.563
Schistosoma mansoni calpain-2 (C02 family) 0.0247 0.0529 0.0422
Trypanosoma brucei cysteine peptidase, putative 0.0247 0.0529 0.1663
Trypanosoma brucei calpain, putative 0.0247 0.0529 0.1663
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0129 0.0126 0.0047
Schistosoma mansoni cathepsin F (C01 family) 0.0235 0.049 0.0382
Brugia malayi calpain D 0.0247 0.0529 0.0422
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0129 0.0126 0.0015
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0129 0.0126 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.0126 0.0047
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0129 0.0126 0.0087
Trypanosoma brucei Calpain-like protein CALP1.3 0.0247 0.0529 0.1663
Echinococcus granulosus prolyl endopeptidase 0.0126 0.0116 0.0005
Trypanosoma cruzi conserved protein 0.0247 0.0529 0.0529
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0247 0.0529 0.0529
Leishmania major calpain family cysteine protease-like protein 0.0247 0.0529 0.136
Trypanosoma brucei cysteine peptidase C (CPC) 0.102 0.318 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0129 0.0126 0.0015
Giardia lamblia Cathepsin B precursor 0.0129 0.0126 0.0032
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.136
Brugia malayi calpain 5 0.0247 0.0529 0.0422
Plasmodium vivax unspecified product 0.0129 0.0126 0.0058
Entamoeba histolytica cysteine proteinase, putative 0.0202 0.0374 0.1563
Loa Loa (eye worm) programmed cell death protein 6 0.0127 0.0116 0.0005
Toxoplasma gondii cathepsin CPC2 0.0129 0.0126 0.0047
Loa Loa (eye worm) hypothetical protein 0.0235 0.049 0.0382
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0129 0.0126 0.0015
Brugia malayi Papain family cysteine protease containing protein 0.0308 0.0737 0.0633
Schistosoma mansoni gamma-secretase subunit aph-1 0.0238 0.0498 0.039
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0247 0.0529 0.136
Plasmodium falciparum cysteine proteinase falcipain 3 0.0308 0.0737 1
Brugia malayi EF hand family protein 0.0127 0.0116 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.0126 0.0047
Giardia lamblia Cathepsin L-like protease 0.0129 0.0126 0.0032
Giardia lamblia Cathepsin L precursor 0.0129 0.0126 0.0032
Echinococcus granulosus cathepsin L cysteine protease 0.0202 0.0374 0.0265
Loa Loa (eye worm) hypothetical protein 0.0129 0.0126 0.0015
Entamoeba histolytica protein kinase, putative 0.0615 0.179 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3008 1 1
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0247 0.0529 0.1663
Schistosoma mansoni cathepsin F (C01 family) 0.0308 0.0737 0.0633
Plasmodium falciparum calpain 0.0247 0.0529 0.6666
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0308 0.0737 0.204
Onchocerca volvulus 0.0308 0.0737 0.1376
Entamoeba histolytica cysteine proteinase, putative 0.0235 0.049 0.2252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0235 0.049 0.1232
Entamoeba histolytica cysteine protease, putative 0.0129 0.0126 0.0087
Brugia malayi Cathepsin L-like cysteine proteinase 0.0235 0.049 0.0382

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 50 nM Inhibitory potency against human Cathepsin K ChEMBL. 15456249
IC50 (binding) = 50 nM Inhibitory potency against human Cathepsin K ChEMBL. 15456249

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.