Detailed information for compound 425836

Basic information

Technical information
  • TDR Targets ID: 425836
  • Name: rubriflorin B
  • MW: 554.585 | Formula: C30H34O10
  • H donors: 0 H acceptors: 5 LogP: 0.48 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)C[C@H]1OC(C2=C1C[C@]13CC[C@]4([C@H]5[C@](O1)(C(=O)C3=CC2=O)O[C@@H]1[C@H](C)C(=O)O[C@@H]1[C@H]5[C@@H](C4=O)C)C)(C)C
  • InChi: 1S/C30H34O10/c1-12-19-22-21(13(2)26(35)37-22)39-30-23(19)28(5,24(12)33)7-8-29(40-30)11-14-17(10-18(32)36-6)38-27(3,4)20(14)16(31)9-15(29)25(30)34/h9,12-13,17,19,21-23H,7-8,10-11H2,1-6H3/t12-,13-,17+,19+,21+,22+,23-,28-,29-,30-/m0/s1
  • InChiKey: SJNBDGQEQVFVTG-ZGWHAFSYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nAChR subunit 0.0046 0.0021 0.0023
Echinococcus multilocularis sterol regulatory element binding protein 0.0109 0.0071 0.008
Echinococcus multilocularis protein vertebrate collagen 0.0043 0.0018 0.002
Trypanosoma cruzi metacaspase, putative 0.0052 0.0026 0.0098
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0256 0.0188 0.8055
Plasmodium vivax aspartyl protease, putative 0.0392 0.0297 0.1163
Toxoplasma gondii beta tubulin 0.0023 0.0002 0.0006
Echinococcus multilocularis integrin alpha ps 0.0091 0.0057 0.0063
Leishmania major beta tubulin 0.0023 0.0002 0.0006
Echinococcus multilocularis caspase 0.0052 0.0026 0.0029
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0146 0.01 0.0451
Onchocerca volvulus 0.0155 0.0107 0.4599
Echinococcus granulosus tubulin subunit beta 0.0023 0.0002 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0256 0.0188 0.0211
Schistosoma mansoni memapsin-2 (A01 family) 0.5283 0.4203 0.4203
Echinococcus multilocularis WAP, kazal, immunoglobulin, kunitz and NTR 0.0043 0.0018 0.002
Trichomonas vaginalis tubulin epsilon chain, putative 0.0023 0.0002 0.0007
Loa Loa (eye worm) RGC/RGC protein kinase 0.0026 0.0005 0.0019
Echinococcus granulosus high voltage activated calcium channel beta 0.0021 0.0001 0.0001
Trypanosoma cruzi beta tubulin, putative 0.0023 0.0002 0.0006
Brugia malayi CHE-14 protein 0.0109 0.0071 0.0279
Loa Loa (eye worm) hypothetical protein 0.0155 0.0107 0.0421
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.006
Onchocerca volvulus 0.0085 0.0052 0.2229
Trypanosoma cruzi meiotic recombination protein DMC1, putative 0.0026 0.0005 0.0016
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0063 0.0034 0.0039
Brugia malayi hypothetical protein 0.0039 0.0015 0.006
Brugia malayi aspartic protease BmAsp-1, identical 0.0313 0.0234 0.0916
Brugia malayi protein ZC84.6 0.0043 0.0018 0.0071
Schistosoma mansoni biogenic amine receptor 0.0256 0.0188 0.0188
Echinococcus multilocularis allatostatin A receptor 0.0256 0.0188 0.0211
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0017 0.0067
Loa Loa (eye worm) TK/ROR protein kinase 0.0149 0.0103 0.0404
Schistosoma mansoni adenoreceptor 0.0256 0.0188 0.0188
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0313 0.0234 0.0234
Entamoeba histolytica tubulin family protein 0.0023 0.0002 0.038
Brugia malayi Guanylate kinase family protein 0.0025 0.0004 0.0016
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0085 0.0052 0.0058
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0313 0.0234 0.0234
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0017 0.0019
Loa Loa (eye worm) kunitz/Bovine pancreatic trypsin inhibitor domain-containing protein 0.0043 0.0018 0.0071
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0256 0.0188 0.0188
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0179 0.0127 0.0497
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0085 0.0052 0.0058
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0256 0.0188 0.0738
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0256 0.0188 0.0188
Loa Loa (eye worm) neuropeptide F receptor 0.0256 0.0188 0.0738
Loa Loa (eye worm) hypothetical protein 0.0052 0.0026 0.01
Echinococcus granulosus myosin light chain kinase smooth muscle 0.0237 0.0173 0.0194
Trichomonas vaginalis cyclin B, putative 0.0042 0.0017 0.0075
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.0025 0.0004 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0256 0.0188 0.0188
Trichomonas vaginalis cyclins, putative 0.0028 0.0007 0.0027
Echinococcus granulosus g protein coupled receptor 0.0256 0.0188 0.0211
Echinococcus multilocularis rhodopsin orphan GPCR 0.0256 0.0188 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0026 0.0113
Giardia lamblia G2/mitotic-specific cyclin B 0.0042 0.0017 0.2003
Echinococcus multilocularis high voltage activated calcium channel beta 0.0021 0.0001 0.0001
Echinococcus granulosus glycine receptor subunit beta 0.0085 0.0052 0.0058
Echinococcus granulosus g protein coupled receptor 0.0256 0.0188 0.0211
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0046 0.0021 0.0081
Entamoeba histolytica hypothetical protein 0.0071 0.004 1
Brugia malayi Glutamate receptor 1 precursor 0.0034 0.0011 0.0044
Echinococcus multilocularis serotonin receptor 0.0256 0.0188 0.0211
Schistosoma mansoni nAChR subunit 0.0085 0.0052 0.0052
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0085 0.0052 0.0058
Brugia malayi RE15519p 0.0256 0.0188 0.0738
Loa Loa (eye worm) latrophilin receptor protein 2 0.0289 0.0214 0.0841
Echinococcus granulosus tm gpcr rhodopsin 0.0256 0.0188 0.0211
Echinococcus multilocularis protoporphyrinogen oxidase 0.0041 0.0017 0.0019
Schistosoma mansoni nAChR subunit 0.0085 0.0052 0.0052
Toxoplasma gondii aspartyl protease ASP1 0.0386 0.0292 0.1143
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0256 0.0188 0.0211
Brugia malayi Guanylate kinase family protein 0.0084 0.0051 0.0201
Trypanosoma cruzi metacaspase 5, putative 0.0052 0.0026 0.0098
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0021 0.0001 0.0002
Schistosoma mansoni neuropeptide receptor 0.085 0.0662 0.0662
Echinococcus granulosus collagen alpha 1XXVIII chain 0.0043 0.0018 0.002
Onchocerca volvulus 0.0256 0.0188 0.8055
Schistosoma mansoni nAChR subunit 0.0085 0.0052 0.0052
Toxoplasma gondii histone lysine-specific demethylase 0.0041 0.0017 0.0064
Loa Loa (eye worm) hypothetical protein 0.0044 0.0019 0.0073
Onchocerca volvulus 0.0256 0.0188 0.8055
Plasmodium falciparum metacaspase-like protein 0.0052 0.0026 0.0098
Loa Loa (eye worm) proteasome subunit beta type 1 0.0057 0.003 0.0116
Echinococcus multilocularis axis inhibition protein axin 0.0035 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0085 0.0052 0.0204
Echinococcus granulosus orexin receptor type 2 0.0256 0.0188 0.0211
Onchocerca volvulus 0.0039 0.0015 0.0655
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0057 0.003 0.7332
Loa Loa (eye worm) integrin alpha pat-2 0.0091 0.0057 0.0222
Schistosoma mansoni tubulin subunit beta 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Schistosoma mansoni regulator of G protein signaling 0.004 0.0015 0.0015
Schistosoma mansoni serine-type protease inhibitor 0.0043 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0013
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0085 0.0052 0.0052
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.2786 0.2209 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.0107 0.0421
Plasmodium vivax aspartyl protease, putative 0.0392 0.0297 0.1163
Brugia malayi Stress-activated protein kinase jnk-1 0.0224 0.0163 0.0639
Leishmania major beta tubulin 0.0023 0.0002 0.0006
Echinococcus multilocularis neuropeptides capa receptor 0.0459 0.0351 0.0393
Schistosoma mansoni neuropeptide receptor 0.0256 0.0188 0.0188
Plasmodium vivax tubulin beta chain, putative 0.0023 0.0002 0.0006
Echinococcus multilocularis neuropeptides capa receptor 0.0256 0.0188 0.0211
Brugia malayi hypothetical protein 0.0313 0.0234 0.0916
Loa Loa (eye worm) hypothetical protein 0.0031 0.0008 0.0033
Brugia malayi DNA repair protein RAD51 homolog 1 0.0026 0.0005 0.0019
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0039 0.0015 0.0017
Schistosoma mansoni regulator of G protein signaling 0.0035 0.0012 0.0012
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0256 0.0188 0.0188
Loa Loa (eye worm) GABA receptor subunit 0.0046 0.0021 0.0081
Loa Loa (eye worm) hypothetical protein 0.0041 0.0017 0.0066
Brugia malayi Dopamine receptor protein 1 0.0256 0.0188 0.0738
Brugia malayi amine oxidase, flavin-containing family protein 0.012 0.0079 0.0311
Echinococcus multilocularis neuropeptide Y receptor 0.0256 0.0188 0.0211
Loa Loa (eye worm) hypothetical protein 0.0046 0.0021 0.0081
Loa Loa (eye worm) beta-tubulin 0.0023 0.0002 0.0008
Trypanosoma cruzi metacaspase, putative 0.0052 0.0026 0.0098
Schistosoma mansoni hypothetical protein 0.0044 0.0019 0.0019
Echinococcus multilocularis WAP, kazal, immunoglobulin, kunitz and NTR 0.0043 0.0018 0.002
Echinococcus multilocularis cyclin B 0.0042 0.0017 0.0019
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0386 0.0292 0.0327
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0293 0.0218 0.0856
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0034 0.0011 0.0012
Echinococcus granulosus axis inhibition protein axin 0.0035 0.0012 0.0013
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0266 0.0196 0.0196
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit beta 0.0049 0.0023 0.0105
Brugia malayi Kunitz/Bovine pancreatic trypsin inhibitor domain containing protein 0.0043 0.0018 0.0071
Plasmodium falciparum tubulin beta chain 0.0023 0.0002 0.0006
Onchocerca volvulus 0.0043 0.0018 0.077
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0052 0.0026 0.0098
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0052 0.0026 0.01
Echinococcus granulosus Niemann Pick C1 protein 0.0109 0.0071 0.008
Echinococcus multilocularis sex peptide receptor 0.0256 0.0188 0.0211
Echinococcus granulosus peptide allatostatin:somatostatin 0.0256 0.0188 0.0211
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0031 0.0008 0.0009
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.3211 0.2548 0.2855
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0146 0.01 0.0391
Schistosoma mansoni neuropeptide F-like receptor 0.0256 0.0188 0.0188
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.2786 0.2209 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0023 0.0002 0.0002
Schistosoma mansoni glutamate receptor kainate 0.0034 0.0011 0.0011
Loa Loa (eye worm) LGC-31 protein 0.0085 0.0052 0.0204
Echinococcus granulosus 7tm_1 domain containing protein 0.0256 0.0188 0.0211
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.3211 0.2548 0.2548
Echinococcus multilocularis Tubulin beta 2C chain 0.0023 0.0002 0.0002
Schistosoma mansoni regulator of G protein signaling 0.0035 0.0012 0.0012
Trypanosoma cruzi CYC2-like cyclin, putative 0.0042 0.0017 0.0065
Schistosoma mansoni nAChR subunit 0.0085 0.0052 0.0052
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0256 0.0188 0.0738
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0179 0.0127 0.0142
Echinococcus granulosus neuropeptides capa receptor 0.0459 0.0351 0.0393
Echinococcus multilocularis caspase 2 0.0174 0.0123 0.0137
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0057 0.003 0.0114
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0313 0.0234 0.0914
Schistosoma mansoni regulator of G protein signaling 0.0035 0.0012 0.0012
Brugia malayi ZU5 domain containing protein 0.0021 0.0001 0.0002
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0125 0.0083 0.0375
Onchocerca volvulus 0.0043 0.0018 0.077
Trichomonas vaginalis cyclins, putative 0.0042 0.0017 0.0075
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0071
Schistosoma mansoni neuropeptide receptor 0.0256 0.0188 0.0188
Brugia malayi hypothetical protein 0.0256 0.0188 0.0738
Entamoeba histolytica tubulin family protein 0.0023 0.0002 0.038
Loa Loa (eye worm) SPON-1 protein 0.0043 0.0018 0.0071
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0039 0.0015 0.006
Echinococcus granulosus protein vertebrate collagen 0.0043 0.0018 0.002
Brugia malayi neuropeptide F receptor 0.0256 0.0188 0.0738
Plasmodium vivax aspartyl proteinase, putative 0.0313 0.0234 0.0914
Echinococcus multilocularis MAGUK p55 subfamily 0.0025 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0624 0.0482 0.1892
Echinococcus granulosus beta tubulin 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Schistosoma mansoni acetylcholine receptor subunit beta 0.0039 0.0015 0.0015
Echinococcus multilocularis axis inhibition protein axin 0.0035 0.0012 0.0013
Brugia malayi Tachykinin-like peptides receptor 99D 0.0256 0.0188 0.0738
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0071
Echinococcus granulosus biogenic amine 5HT receptor 0.0256 0.0188 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0012 0.0052
Echinococcus granulosus fmrfamide receptor 0.0256 0.0188 0.0211
Loa Loa (eye worm) G-protein coupled receptor 0.0256 0.0188 0.0738
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0293 0.0218 0.0856
Echinococcus multilocularis g protein coupled receptor 0.0256 0.0188 0.0211
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0025 0.0004 0.0004
Brugia malayi Kunitz/Bovine pancreatic trypsin inhibitor domain containing protein 0.0043 0.0018 0.0071
Entamoeba histolytica hypothetical protein 0.0046 0.0021 0.5046
Schistosoma mansoni MAGUK homolog 0.0027 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Schistosoma mansoni opsin-like receptor 0.0256 0.0188 0.0188
Schistosoma mansoni nAChR subunit 0.0039 0.0015 0.0015
Schistosoma mansoni amine oxidase 0.0041 0.0017 0.0017
Toxoplasma gondii beta-1 tubulin, putative 0.0023 0.0002 0.0006
Entamoeba histolytica hypothetical protein 0.0035 0.0012 0.2883
Echinococcus granulosus neuropeptide receptor A26 0.0256 0.0188 0.0211
Loa Loa (eye worm) melatonin receptor type 1A 0.0256 0.0188 0.0738
Brugia malayi hypothetical protein 0.0256 0.0188 0.0738
Brugia malayi latrophilin 2 splice variant baaae 0.0624 0.0482 0.1892
Onchocerca volvulus 0.0035 0.0012 0.0504
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0085 0.0052 0.0204
Echinococcus granulosus rhodopsin orphan GPCR 0.0256 0.0188 0.0211
Schistosoma mansoni serine-type protease inhibitor 0.0043 0.0018 0.0018
Brugia malayi Pepsin A precursor 0.0313 0.0234 0.0916
Brugia malayi Kringle domain containing protein 0.0145 0.01 0.0391
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0162 0.0113 0.0445
Echinococcus multilocularis neuropeptide receptor 0.0256 0.0188 0.0211
Echinococcus multilocularis Regulator of G protein signaling 20 0.0035 0.0012 0.0013
Schistosoma mansoni neurotransmitter gated ion channel 0.0046 0.0021 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.01 0.0389
Leishmania major beta tubulin 0.0023 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.3211 0.2548 1
Echinococcus granulosus expressed protein 0.0043 0.0018 0.002
Plasmodium falciparum sortilin 0.0136 0.0093 0.0361
Trichomonas vaginalis meiosis-specific recA homolog Dmc1 0.0026 0.0005 0.0019
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Echinococcus multilocularis rhodopsin orphan GPCR 0.0256 0.0188 0.0211
Loa Loa (eye worm) ACC-1 protein 0.0085 0.0052 0.0204
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0146 0.01 0.0391
Brugia malayi excitatory GABA receptor EXP-1A 0.0085 0.0052 0.0204
Loa Loa (eye worm) hypothetical protein 0.0042 0.0017 0.0067
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0256 0.0188 0.0738
Plasmodium falciparum plasmepsin III 0.0313 0.0234 0.0914
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0146 0.01 0.01
Schistosoma mansoni biogenic amine receptor 0.0256 0.0188 0.0188
Onchocerca volvulus 0.0313 0.0234 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0386 0.0292 0.1145
Brugia malayi sulfakinin receptor protein 0.0256 0.0188 0.0738
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0071
Plasmodium vivax aspartyl protease, putative 0.0313 0.0234 0.0914
Schistosoma mansoni amine GPCR 0.0256 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0109 0.0071 0.0279
Plasmodium falciparum plasmepsin II 0.0386 0.0292 0.1143
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.228 0.1805 0.1805
Loa Loa (eye worm) hypothetical protein 0.0085 0.0052 0.0204
Echinococcus granulosus kelch ECH associated protein 1 like 0.0282 0.0209 0.0234
Echinococcus multilocularis apoptotic protease activating factor 1 0.0122 0.0081 0.0091
Onchocerca volvulus 0.0145 0.01 0.4271
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0109 0.0071 0.0279
Plasmodium falciparum plasmepsin VI 0.0386 0.0292 0.1143
Schistosoma mansoni cyclin B 0.0042 0.0017 0.0017
Echinococcus multilocularis dna repair protein rad51 1 0.0026 0.0005 0.0005
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0266 0.0196 0.0769
Brugia malayi Dopamine receptor 0.0256 0.0188 0.0738
Loa Loa (eye worm) hypothetical protein 0.0122 0.0081 0.0318
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0085 0.0052 0.0204
Loa Loa (eye worm) aspartyl protease 6 0.0313 0.0234 0.0916
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0047
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.1002 0.0784 0.3547
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0266 0.0196 0.0767
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0293 0.0218 0.0244
Brugia malayi larval opioid receptor 0.0256 0.0188 0.0738
Entamoeba histolytica cyclin, putative 0.0042 0.0017 0.4173
Loa Loa (eye worm) RGC/RGC protein kinase 0.0026 0.0005 0.0019
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0031 0.0008 0.0008
Echinococcus multilocularis serotonin receptor 0.0256 0.0188 0.0211
Loa Loa (eye worm) hypothetical protein 0.0266 0.0196 0.0769
Loa Loa (eye worm) RGS-3 protein 0.0035 0.0012 0.0047
Onchocerca volvulus 0.0162 0.0113 0.4858
Schistosoma mansoni amine GPCR 0.0256 0.0188 0.0188
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0039 0.0015 0.0017
Echinococcus granulosus Kunitz protease inhibitor 0.0043 0.0018 0.002
Echinococcus granulosus neuropeptide receptor 0.085 0.0662 0.0742
Brugia malayi Protein kinase domain containing protein 0.0033 0.001 0.0039
Schistosoma mansoni DNA repair protein RAD51 0.0026 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Brugia malayi Kunitz/Bovine pancreatic trypsin inhibitor domain containing protein 0.0043 0.0018 0.0071
Schistosoma mansoni biogenic amine (5HT) receptor 0.0256 0.0188 0.0188
Echinococcus granulosus neuropeptide FF receptor 2 0.0256 0.0188 0.0211
Schistosoma mansoni alpha-1 adrenergic receptor 0.0256 0.0188 0.0188
Trypanosoma brucei RNA helicase, putative 0.0113 0.0074 0.0287
Echinococcus multilocularis protein patched 0.0109 0.0071 0.008
Brugia malayi Serotonin receptor 0.0256 0.0188 0.0738
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0256 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.006
Toxoplasma gondii kringle domain-containing protein 0.0145 0.01 0.0389
Leishmania major beta tubulin 0.0023 0.0002 0.0006
Echinococcus granulosus Tubulin beta 2C chain 0.0023 0.0002 0.0002
Echinococcus multilocularis expressed protein 0.0043 0.0018 0.002
Onchocerca volvulus 0.0043 0.0018 0.077
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0146 0.01 0.0391
Trypanosoma brucei metacaspase 5, putative 0.0052 0.0026 0.0098
Schistosoma mansoni glutamate receptor kainate 0.0034 0.0011 0.0011
Echinococcus granulosus Kunitz protease inhibitor 0.0043 0.0018 0.002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0071
Echinococcus granulosus collagen alpha 3VI chain 0.0043 0.0018 0.002
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0085 0.0052 0.0204
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0145 0.01 0.0389
Echinococcus multilocularis Tubulin beta 2C chain 0.0023 0.0002 0.0002
Trichomonas vaginalis cyclin A, putative 0.0042 0.0017 0.0075
Echinococcus multilocularis glycine receptor subunit beta 0.0085 0.0052 0.0058
Schistosoma mansoni integrin alpha-ps 0.0047 0.0022 0.0022
Brugia malayi hypothetical protein 0.0313 0.0234 0.0916
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0293 0.0218 0.0244
Echinococcus multilocularis integrin beta 2 0.025 0.0184 0.0206
Onchocerca volvulus 0.0256 0.0188 0.8055
Leishmania major beta tubulin 0.0023 0.0002 0.0006
Echinococcus granulosus biogenic amine 5HT receptor 0.0256 0.0188 0.0211
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.3211 0.2548 1
Echinococcus multilocularis g-protein coupled receptor 0.0256 0.0188 0.0211
Brugia malayi hypothetical protein 0.0051 0.0025 0.0097
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0071
Brugia malayi Uncoordinated protein 44 0.0031 0.0008 0.0033
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Echinococcus multilocularis G protein coupled receptor 139 0.085 0.0662 0.0742
Plasmodium vivax proteasome subunit beta type-1, putative 0.0057 0.003 0.0114
Brugia malayi SWIRM domain containing protein 0.0162 0.0113 0.0445
Onchocerca volvulus 0.0046 0.0021 0.0882
Onchocerca volvulus 0.0039 0.0015 0.0655
Echinococcus multilocularis glycine receptor subunit beta 0.0085 0.0052 0.0058
Echinococcus granulosus Tubulin beta 2C chain 0.0023 0.0002 0.0002
Echinococcus multilocularis glutamate receptor 2 0.0026 0.0005 0.0005
Onchocerca volvulus Cell death protein 3 homolog 0.0174 0.0123 0.5252
Echinococcus granulosus Tubulin beta 2C chain 0.0023 0.0002 0.0002
Onchocerca volvulus 0.0085 0.0052 0.2229
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.3211 0.2548 1
Brugia malayi Guanylate kinase family protein 0.0021 0.0001 0.0002
Entamoeba histolytica hypothetical protein 0.0071 0.004 1
Mycobacterium ulcerans oxidoreductase 0.0041 0.0017 0.0076
Brugia malayi G protein-coupled receptor F59B2.13 0.0256 0.0188 0.0738
Schistosoma mansoni hypothetical protein 0.0289 0.0214 0.0214
Echinococcus multilocularis GPCR, family 2 0.0289 0.0214 0.024
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0085 0.0052 0.0204
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0085 0.0052 0.0204
Schistosoma mansoni MAGUK homolog 0.0025 0.0004 0.0004
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0179 0.0127 0.0142
Loa Loa (eye worm) hypothetical protein 0.0386 0.0292 0.1145
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0041 0.0017 0.0074
Echinococcus granulosus MAGUK p55 subfamily 0.0025 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0012 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0026 0.0113
Brugia malayi Regulator of G protein signaling domain containing protein 0.0035 0.0012 0.0047
Brugia malayi Receptor family ligand binding region containing protein 0.0026 0.0005 0.0019
Brugia malayi PXA domain containing protein 0.0035 0.0012 0.0047
Brugia malayi Glutamate receptor 2 precursor 0.0034 0.0011 0.0044
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0155 0.0107 0.0107
Echinococcus multilocularis regulator of G protein signaling 0.0035 0.0012 0.0013
Echinococcus granulosus beta tubulin 0.0023 0.0002 0.0002
Echinococcus granulosus axis inhibition protein axin 0.0035 0.0012 0.0013
Echinococcus multilocularis regulator of G protein signaling 3 0.0035 0.0012 0.0013
Leishmania major beta tubulin 0.0023 0.0002 0.0006
Brugia malayi Kunitz/Bovine pancreatic trypsin inhibitor domain containing protein 0.0043 0.0018 0.0071
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0041 0.0017 0.0064
Echinococcus multilocularis beta tubulin 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0115 0.0076 0.0298
Echinococcus multilocularis amyloid beta A4 protein 0.0043 0.0018 0.002
Toxoplasma gondii aspartyl protease 0.0313 0.0234 0.0914
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0027 0.0006 0.0006
Brugia malayi A-kinase anchor protein 10, precursor 0.0035 0.0012 0.0047
Trypanosoma brucei mitotic cyclin 6 0.0042 0.0017 0.0065
Plasmodium falciparum plasmepsin VII 0.0313 0.0234 0.0914
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0256 0.0188 0.0738
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0057 0.003 0.0114
Brugia malayi beta-tubulin, identical 0.0023 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Schistosoma mansoni hypothetical protein 0.0256 0.0188 0.0188
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0085 0.0052 0.0058
Loa Loa (eye worm) hypothetical protein 0.0046 0.0021 0.0081
Plasmodium vivax plasmepsin IV, putative 0.0386 0.0292 0.1143
Loa Loa (eye worm) PXA domain-containing protein 0.0035 0.0012 0.0047
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0047 0.0021 0.0024
Echinococcus granulosus glycine receptor subunit alpha 1 0.0085 0.0052 0.0058
Entamoeba histolytica hypothetical protein 0.0071 0.004 1
Echinococcus granulosus caspase 8 0.0052 0.0026 0.0029
Onchocerca volvulus 0.0122 0.0081 0.3466
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0027 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0085 0.0052 0.0204
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0224 0.0163 0.0639
Echinococcus granulosus glycine receptor subunit beta 0.0085 0.0052 0.0058
Loa Loa (eye worm) G-protein coupled receptor 0.0256 0.0188 0.0738
Brugia malayi hypothetical protein 0.0256 0.0188 0.0738
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0071
Loa Loa (eye worm) hypothetical protein 0.0044 0.0019 0.0073
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.0025 0.0004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0085 0.0052 0.0204
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0256 0.0188 0.0188
Plasmodium vivax plasmepsin V, putative 0.0313 0.0234 0.0914
Giardia lamblia Beta tubulin 0.0023 0.0002 0.0182
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0039 0.0015 0.0017
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0039 0.0015 0.006
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Schistosoma mansoni nAChR subunit 0.0085 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0047
Echinococcus multilocularis kelch ECH associated protein 1 0.0282 0.0209 0.0234
Echinococcus granulosus caspase 0.0052 0.0026 0.0029
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0289 0.0214 0.024
Loa Loa (eye worm) hypothetical protein 0.0085 0.0052 0.0204
Loa Loa (eye worm) hypothetical protein 0.0293 0.0218 0.0856
Leishmania major beta tubulin 0.0023 0.0002 0.0006
Brugia malayi Kunitz/Bovine pancreatic trypsin inhibitor domain containing protein 0.0043 0.0018 0.0071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.006
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0042 0.0017 0.0065
Plasmodium falciparum metacaspase 1 0.0052 0.0026 0.0098
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0046 0.0021 0.0081
Schistosoma mansoni maguk P55 subfamily member 26 0.0021 0.0001 0.0001
Echinococcus multilocularis Kunitz:Bovine pancreatic trypsin inhibitor 0.0043 0.0018 0.002
Schistosoma mansoni hypothetical protein 0.0624 0.0482 0.0482
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0026 0.0113
Echinococcus multilocularis tissue type plasminogen activator 0.0145 0.01 0.0112
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0071
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Echinococcus granulosus glutamate receptor 2 0.0039 0.0015 0.0017
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0256 0.0188 0.0738
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0012 0.0052
Schistosoma mansoni high voltage-activated calcium channel beta subunit 1 0.0021 0.0001 0.0001
Echinococcus multilocularis Kelch repeat type 1 0.0282 0.0209 0.0235
Mycobacterium leprae conserved hypothetical protein 0.0425 0.0323 0.1463
Brugia malayi Kunitz/Bovine pancreatic trypsin inhibitor domain containing protein 0.0043 0.0018 0.0071
Schistosoma mansoni glutamate receptor AMPA 0.0034 0.0011 0.0011
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0085 0.0052 0.0058
Brugia malayi Melatonin receptor type 1A 0.0256 0.0188 0.0738
Brugia malayi Dopamine receptor protein 2 0.0256 0.0188 0.0738
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.006
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.006
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0256 0.0188 0.0211
Onchocerca volvulus 0.0256 0.0188 0.8055
Entamoeba histolytica DNA repair protein RAD51, putative 0.0026 0.0005 0.1058
Echinococcus granulosus high voltage activated calcium channel beta 0.0021 0.0001 0.0001
Schistosoma mansoni amine GPCR 0.0256 0.0188 0.0188
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0049 0.0023 0.0089
Echinococcus multilocularis orexin receptor type 2 0.0256 0.0188 0.0211
Echinococcus granulosus Regulator of G protein signaling 20 0.0035 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0051 0.0025 0.0097
Trichomonas vaginalis cyclin B, putative 0.0042 0.0017 0.0075
Brugia malayi protein C37C3.6a 0.0043 0.0018 0.0071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.006
Schistosoma mansoni hypothetical protein 0.0122 0.0081 0.0081
Echinococcus granulosus integrin beta 2 0.025 0.0184 0.0206
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0146 0.01 0.0391
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0025 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0043 0.0018 0.0018
Brugia malayi Eukaryotic aspartyl protease family protein 0.0313 0.0234 0.0916
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN) 0.0049 0.0023 0.0103
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0047 0.0022 0.0085
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0015 0.006
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.3211 0.2548 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0256 0.0188 0.0211
Onchocerca volvulus 0.0046 0.0021 0.0882
Echinococcus granulosus collagen alpha 3VI chain 0.0043 0.0018 0.002
Brugia malayi map kinase activated protein kinase protein 2 0.0179 0.0127 0.0497
Trichomonas vaginalis cyclin B, putative 0.0042 0.0017 0.0075
Echinococcus multilocularis receptor type guanylyl cyclase 0.0026 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0046 0.0021 0.0081
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0289 0.0214 0.024
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0233 0.017 0.0668
Brugia malayi Kelch motif family protein 0.0051 0.0025 0.0097
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0039 0.0015 0.0017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0047
Echinococcus granulosus hypothetical protein 0.0043 0.0018 0.002
Echinococcus granulosus guanylate kinase 0.0021 0.0001 0.0001
Schistosoma mansoni neurotransmitter gated ion channel 0.0039 0.0015 0.0015
Onchocerca volvulus 0.0256 0.0188 0.8055
Schistosoma mansoni glutamate receptor kainate 0.0034 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0002
Brugia malayi Latrophilin receptor protein 2 0.0289 0.0214 0.0841
Echinococcus multilocularis neuropeptide receptor A26 0.0256 0.0188 0.0211
Schistosoma mansoni amine GPCR 0.0256 0.0188 0.0188
Schistosoma mansoni hypothetical protein 0.0145 0.01 0.01
Trypanosoma cruzi DNA repair protein RAD51, putative 0.0026 0.0005 0.0016
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0057 0.003 0.0114
Trypanosoma cruzi metacaspase 5, putative 0.0052 0.0026 0.0098
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0085 0.0052 0.0052
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0233 0.017 0.0191
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0146 0.01 0.0391
Echinococcus multilocularis Papilin 0.0043 0.0018 0.002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0289 0.0214 0.0841
Schistosoma mansoni caspase-3 (C14 family) 0.0052 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0046 0.0021 0.0081
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0026 0.0113
Echinococcus multilocularis nAChR subunit 0.0085 0.0052 0.0058
Loa Loa (eye worm) hypothetical protein 0.0913 0.0713 0.2796
Trypanosoma brucei beta tubulin 0.0023 0.0002 0.0006
Trypanosoma cruzi metacaspase, putative 0.0052 0.0026 0.0098
Schistosoma mansoni hypothetical protein 0.0031 0.0008 0.0008
Echinococcus multilocularis sortilin 0.0136 0.0093 0.0104
Echinococcus multilocularis beta tubulin 0.0023 0.0002 0.0002
Echinococcus multilocularis glutamate receptor 2 0.0039 0.0015 0.0017
Echinococcus multilocularis expressed protein 0.0043 0.0018 0.002
Onchocerca volvulus 0.0256 0.0188 0.8055
Brugia malayi hypothetical protein 0.0021 0.0001 0.0002
Onchocerca volvulus 0.0313 0.0234 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0071
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.2786 0.2209 1
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit beta 0.0146 0.01 0.0451
Echinococcus multilocularis expressed protein 0.0035 0.0012 0.0013
Schistosoma mansoni nAChR subunit 0.0085 0.0052 0.0052
Loa Loa (eye worm) tubulin beta-2A chain 0.0023 0.0002 0.0008
Echinococcus multilocularis collagen alpha 3(VI) chain 0.0043 0.0018 0.002
Loa Loa (eye worm) hypothetical protein 0.0046 0.0021 0.0081
Brugia malayi Serotonin receptor 0.0256 0.0188 0.0738
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0039 0.0015 0.0017
Echinococcus multilocularis regulator of G protein signaling 3 0.0035 0.0012 0.0013
Echinococcus granulosus kelch ECH associated protein 1 like 0.0282 0.0209 0.0234
Mycobacterium ulcerans transcriptional regulator NrdR 0.0425 0.0323 0.1465
Echinococcus granulosus expressed protein 0.0035 0.0012 0.0013
Mycobacterium ulcerans guanylate kinase 0.0021 0.0001 0.0002
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0085 0.0052 0.0052
Echinococcus multilocularis neuropeptide Y receptor 0.0256 0.0188 0.0211
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0233 0.017 0.0668
Echinococcus granulosus integrin alpha ps 0.0044 0.0019 0.0021
Echinococcus multilocularis disks large 3 0.0077 0.0045 0.005
Plasmodium falciparum plasmepsin X 0.0392 0.0297 0.1163
Onchocerca volvulus Papilin homolog 0.0043 0.0018 0.077
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0039 0.0015 0.0017
Brugia malayi hypothetical protein 0.0039 0.0015 0.006
Trichomonas vaginalis cyclins, putative 0.0042 0.0017 0.0075
Loa Loa (eye worm) hypothetical protein 0.0125 0.0084 0.0329
Brugia malayi aspartic protease BmAsp-2, identical 0.0313 0.0234 0.0916
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Echinococcus granulosus c-Jun N-terminal kinases 0.0224 0.0163 0.0183
Schistosoma mansoni nAChR subunit 0.0039 0.0015 0.0015
Brugia malayi abnormal cell lineage protein 2 0.0021 0.0001 0.0002
Echinococcus multilocularis neuropeptide s receptor 0.0256 0.0188 0.0211
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0256 0.0188 0.0211
Brugia malayi Kunitz/Bovine pancreatic trypsin inhibitor domain containing protein 0.0043 0.0018 0.0071
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.3211 0.2548 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0256 0.0188 0.0211
Echinococcus multilocularis integrin alpha ps 0.0091 0.0057 0.0063
Trichomonas vaginalis tubulin alpha chain, putative 0.0023 0.0002 0.0007
Schistosoma mansoni serine-type protease inhibitor 1.1981 0.9552 0.9552
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0155 0.0107 0.0107
Leishmania major RAD51/dmc1 protein 0.0026 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.0025 0.0004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0047 0.0022 0.0085
Schistosoma mansoni f-spondin 0.0043 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0289 0.0214 0.0841
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0052 0.0026 0.0098
Entamoeba histolytica hypothetical protein 0.0035 0.0012 0.2883
Echinococcus granulosus netrin receptor unc 5 0.0031 0.0008 0.0009
Echinococcus granulosus lysine specific histone demethylase 1A 0.0151 0.0104 0.0117
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0256 0.0188 0.0211
Echinococcus granulosus regulator of G protein signaling 7 0.0035 0.0012 0.0013
Schistosoma mansoni cathepsin D (A01 family) 0.0664 0.0514 0.0514
Schistosoma mansoni hypothetical protein 0.004 0.0016 0.0016
Echinococcus granulosus g-protein coupled receptor 0.0256 0.0188 0.0211
Echinococcus multilocularis regulator of G protein signaling 7 0.0035 0.0012 0.0013
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.004 0.004
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0041 0.0017 0.0076
Echinococcus granulosus MAGUK p55 subfamily 0.0025 0.0004 0.0004
Onchocerca volvulus 0.0155 0.0107 0.4599
Schistosoma mansoni axis inhibition protein axin 0.0035 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Echinococcus granulosus dro:myosuppressin receptor 0.0256 0.0188 0.0211
Leishmania major hypothetical protein, conserved 0.0145 0.01 0.0389
Leishmania major beta tubulin 0.0023 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0071
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0386 0.0292 0.1143
Loa Loa (eye worm) hypothetical protein 0.0313 0.0234 0.0916
Loa Loa (eye worm) hypothetical protein 0.0085 0.0052 0.0204
Echinococcus granulosus disks large 3 0.0077 0.0045 0.005
Echinococcus multilocularis MAGUK p55 subfamily 0.0025 0.0004 0.0004
Onchocerca volvulus 0.0256 0.0188 0.8055
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0017 0.0064
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0256 0.0188 0.0211
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0035 0.0012 0.0013
Trypanosoma brucei beta tubulin 0.0023 0.0002 0.0006
Brugia malayi hypothetical protein 0.0256 0.0188 0.0738
Schistosoma mansoni regulator of G protein signaling 0.0035 0.0012 0.0012
Onchocerca volvulus 0.0256 0.0188 0.8055
Loa Loa (eye worm) tubulin beta chain 0.0023 0.0002 0.0008
Schistosoma mansoni serine/threonine protein kinase 0.012 0.008 0.008
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0026 0.0113
Echinococcus multilocularis tubulin subunit beta 0.0023 0.0002 0.0002
Mycobacterium ulcerans monoamine oxidase 0.0041 0.0017 0.0076
Echinococcus granulosus egf domain protein 0.0043 0.0018 0.002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0047
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0085 0.0052 0.0058
Onchocerca volvulus 0.0256 0.0188 0.8055
Loa Loa (eye worm) guanylate kinase 0.0025 0.0004 0.0016
Echinococcus multilocularis kelch ECH associated protein 1 0.0282 0.0209 0.0234
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Brugia malayi follicle stimulating hormone receptor 0.0256 0.0188 0.0738
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 1.1195 0.8924 1
Onchocerca volvulus 0.0043 0.0018 0.077
Echinococcus multilocularis Papilin 0.0043 0.0018 0.002
Loa Loa (eye worm) kunitz/Bovine pancreatic trypsin inhibitor domain-containing protein 0.0043 0.0018 0.0071
Onchocerca volvulus 0.0085 0.0052 0.2229
Schistosoma mansoni serine-type protease inhibitor 0.0043 0.0018 0.0018
Echinococcus granulosus dna repair protein rad51 1 0.0026 0.0005 0.0005
Onchocerca volvulus Netrin receptor homolog 0.0034 0.0011 0.0455
Echinococcus granulosus neuropeptide Y receptor 0.0256 0.0188 0.0211
Onchocerca volvulus 0.0043 0.0018 0.077
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0085 0.0052 0.0204
Brugia malayi Tubulin beta-1 chain 0.0023 0.0002 0.0008
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0146 0.01 0.0112
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0085 0.0052 0.0204
Schistosoma mansoni histamine h1 receptor 0.0256 0.0188 0.0188
Trichomonas vaginalis cyclins, putative 0.0042 0.0017 0.0075
Echinococcus multilocularis 0.0025 0.0004 0.0004
Echinococcus multilocularis proteinase inhibitor I2, Kunitz metazoa 0.0043 0.0018 0.002
Echinococcus granulosus Tubulin beta 2C chain 0.0023 0.0002 0.0002
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0085 0.0052 0.0204
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit beta 0.0146 0.01 0.0391
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0266 0.0196 0.0219
Echinococcus granulosus tubulin beta 4A class IVa 0.0023 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0289 0.0214 0.0214
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.012 0.008 0.0312
Loa Loa (eye worm) glutamate receptor 1 0.0034 0.0011 0.0044
Brugia malayi AKH receptor 0.0256 0.0188 0.0738
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.006
Schistosoma mansoni hypothetical protein 0.0256 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Schistosoma mansoni integrin alpha-ps 0.0091 0.0057 0.0057
Echinococcus granulosus hypothetical protein 0.0256 0.0188 0.0211
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0044 0.0019 0.0073
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0151 0.0104 0.0104
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0085 0.0052 0.0058
Schistosoma mansoni maguk P55 subfamily member 35 0.0025 0.0004 0.0004
Brugia malayi Cation transporter family protein 0.0155 0.0107 0.0421
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0256 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0085 0.0052 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0026 0.0113
Trypanosoma cruzi cyclin, putative 0.0042 0.0017 0.0065
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0085 0.0052 0.0204
Brugia malayi Cell death protein 3 precursor 0.0174 0.0123 0.0481
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0041 0.0017 0.0017
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0085 0.0052 0.0204
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0256 0.0188 0.0188
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0224 0.0163 0.0183
Echinococcus granulosus disks large 1 0.0021 0.0001 0.0001
Schistosoma mansoni protein kinase 0.0026 0.0005 0.0005
Brugia malayi EB module family protein 0.0043 0.0018 0.0071
Echinococcus granulosus atrial natriuretic peptide receptor 0.0023 0.0002 0.0002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0913 0.0713 0.2796
Echinococcus multilocularis 0.0041 0.0017 0.0019
Onchocerca volvulus Papilin homolog 0.0043 0.0018 0.077
Trypanosoma cruzi metacaspase, putative 0.0052 0.0026 0.0098
Loa Loa (eye worm) kunitz/Bovine pancreatic trypsin inhibitor domain-containing protein 0.0043 0.0018 0.0071
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0256 0.0188 0.0211
Brugia malayi hypothetical protein 0.0071 0.004 0.0158
Loa Loa (eye worm) rad51 0.0026 0.0005 0.0019
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0146 0.01 0.0391
Echinococcus granulosus Papilin 0.0043 0.0018 0.002
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0039 0.0015 0.0017
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0026 0.0113
Brugia malayi Calcium binding EGF domain containing protein 0.0043 0.0018 0.0071
Schistosoma mansoni serine/threonine protein kinase 0.012 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0282 0.0209 0.0209
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0085 0.0052 0.0058
Loa Loa (eye worm) BEN-1 protein 0.0023 0.0002 0.0008
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0057 0.003 0.0033
Echinococcus granulosus amyloid protein 2 like 0.0043 0.0018 0.002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0071
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0071
Loa Loa (eye worm) TYRA-2 protein 0.0256 0.0188 0.0738
Echinococcus granulosus Tubulin beta 2C chain 0.0023 0.0002 0.0002
Echinococcus granulosus 7TM GPCR rhodopsin 0.0256 0.0188 0.0211
Echinococcus granulosus rhodopsin orphan GPCR 0.0256 0.0188 0.0211
Schistosoma mansoni ATP-dependent RNA Helicase 0.0025 0.0004 0.0004
Onchocerca volvulus 0.0043 0.0018 0.077
Echinococcus multilocularis neuropeptide FF receptor 2 0.0256 0.0188 0.0211
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0256 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0042 0.0017 0.0067
Trypanosoma cruzi DNA repair protein RAD51, putative 0.0026 0.0005 0.0016
Brugia malayi PXA domain containing protein 0.0035 0.0012 0.0047
Brugia malayi hypothetical protein 0.0122 0.0081 0.0318
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0026 0.0113
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0386 0.0292 0.1319
Echinococcus multilocularis disks large 1 0.0021 0.0001 0.0001
Schistosoma mansoni integrin beta subunit 0.0199 0.0143 0.0143
Echinococcus granulosus apoptotic protease activating factor 1 0.0122 0.0081 0.0091
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0256 0.0188 0.0211
Plasmodium vivax ribonucleotide reductase small subunit, putative 0.0049 0.0023 0.0089
Leishmania major beta tubulin 0.0023 0.0002 0.0006
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0017 0.0064
Trypanosoma brucei Metacaspase-4 0.0052 0.0026 0.0098
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0015 0.006
Onchocerca volvulus 0.0039 0.0015 0.0655
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0041 0.0017 0.0076
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0041 0.0017 0.0064
Brugia malayi ORL1-like opioid receptor 0.0256 0.0188 0.0738
Schistosoma mansoni hypothetical protein 0.0289 0.0214 0.0214
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0023 0.0002 0.0002
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0017 0.0064
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Echinococcus granulosus rhodopsin orphan GPCR 0.0256 0.0188 0.0211
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0855 0.0666 0.2613
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0026 0.0113
Brugia malayi hypothetical protein 0.0039 0.0015 0.006
Schistosoma mansoni caspase-7 (C14 family) 0.0052 0.0026 0.0026
Plasmodium falciparum plasmepsin IV 0.0386 0.0292 0.1143
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Echinococcus multilocularis collagen alpha 1(XXVIII) chain 0.0043 0.0018 0.002
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0041 0.0017 0.0064
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0017 0.0064
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0256 0.0188 0.0211
Brugia malayi proteasome subunit beta type 1 0.0057 0.003 0.0116
Loa Loa (eye worm) bone morphogenic protein 6 0.0063 0.0034 0.0135
Echinococcus multilocularis MAGUK p55 subfamily 0.0025 0.0004 0.0004
Brugia malayi G-protein coupled receptor 0.0256 0.0188 0.0738
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0125 0.0083 0.0375
Schistosoma mansoni integrin alpha-4 0.0389 0.0295 0.0295
Echinococcus granulosus G protein coupled receptor kinase 1 0.0085 0.0051 0.0058
Leishmania major beta tubulin 0.0023 0.0002 0.0006
Echinococcus multilocularis fmrfamide receptor 0.0256 0.0188 0.0211
Brugia malayi Death domain containing protein 0.0031 0.0008 0.0033
Echinococcus multilocularis Kunitz protease inhibitor 0.0043 0.0018 0.002
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0256 0.0188 0.0211
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0256 0.0188 0.0738
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0057 0.003 0.0033
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0052 0.0204
Echinococcus multilocularis fmrfamide receptor 0.0256 0.0188 0.0211
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0256 0.0188 0.0188
Schistosoma mansoni hypothetical protein 0.0256 0.0188 0.0188
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0313 0.0234 0.0916
Schistosoma mansoni axis inhibition protein axin 0.0035 0.0012 0.0012
Echinococcus granulosus tachykinin peptides receptor 99D 0.0256 0.0188 0.0211
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0026 0.0113
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0039 0.0015 0.0017
Brugia malayi hypothetical protein 0.0256 0.0188 0.0738
Echinococcus granulosus alpha 1A adrenergic receptor 0.0256 0.0188 0.0211
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0052 0.0204
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0047
Echinococcus granulosus kunitz type serine protease inhibitor 6 0.0043 0.0018 0.002
Onchocerca volvulus 0.0256 0.0188 0.8055
Schistosoma mansoni integrin alpha 0.0091 0.0057 0.0057
Echinococcus granulosus sex peptide receptor 0.0256 0.0188 0.0211
Loa Loa (eye worm) hypothetical protein 0.0085 0.0052 0.0204
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0039 0.0015 0.006
Echinococcus multilocularis Niemann Pick C1 protein 0.0109 0.0071 0.008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0256 0.0188 0.0211
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0071
Onchocerca volvulus Tfpi2 protein homolog 0.0043 0.0018 0.077
Brugia malayi hypothetical protein 0.0035 0.0012 0.0047
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0072 0.0042 0.0163
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0085 0.0051 0.0058
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Echinococcus multilocularis Tubulin beta 2C chain 0.0023 0.0002 0.0002
Trypanosoma cruzi cyclin 6, putative 0.0042 0.0017 0.0065
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Trichomonas vaginalis tubulin beta chain, putative 0.0023 0.0002 0.0007
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0085 0.0052 0.0058
Loa Loa (eye worm) hypothetical protein 0.0108 0.007 0.0275
Brugia malayi hypothetical protein 0.0256 0.0188 0.0738
Loa Loa (eye worm) acetylcholine receptor protein 0.0039 0.0015 0.006
Echinococcus multilocularis g protein coupled receptor 0.0256 0.0188 0.0211
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0085 0.0052 0.0058
Echinococcus multilocularis trypsin inhibitor 0.0043 0.0018 0.002
Schistosoma mansoni hypothetical protein 0.0043 0.0018 0.0018
Schistosoma mansoni glutamate receptor NMDA 0.0034 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0033 0.001 0.001
Brugia malayi Peripheral plasma membrane protein CASK 0.0033 0.001 0.004
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0146 0.01 0.0451
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0146 0.01 0.0391
Echinococcus multilocularis Tubulin beta 2C chain 0.0023 0.0002 0.0002
Plasmodium vivax sortilin, putative 0.0136 0.0093 0.0361
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0046 0.0021 0.0081
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0256 0.0188 0.0211
Brugia malayi Kunitz/Bovine pancreatic trypsin inhibitor domain containing protein 0.0043 0.0018 0.0071
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.2786 0.2209 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0256 0.0188 0.0188
Echinococcus granulosus glycine receptor subunit alpha 1 0.0085 0.0052 0.0058
Echinococcus granulosus integrin alpha 3 0.0044 0.0019 0.0021
Echinococcus granulosus nAChR subunit 0.0085 0.0052 0.0058
Schistosoma mansoni tubulin subunit beta 0.0023 0.0002 0.0002
Echinococcus multilocularis integrin alpha 3 0.0044 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.006
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0046 0.0021 0.0021
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0047 0.0021 0.0024
Echinococcus granulosus regulator of G protein signaling 3 0.0035 0.0012 0.0013
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0313 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0145 0.01 0.0391
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Echinococcus multilocularis somatostatin receptor 0.0256 0.0188 0.0211
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0256 0.0188 0.0188
Schistosoma mansoni sortilin 0.0096 0.0061 0.0061
Toxoplasma gondii meiotic recombination protein DMC1 family protein 0.0026 0.0005 0.0016
Onchocerca volvulus 0.0155 0.0107 0.4599
Loa Loa (eye worm) BEN-1 protein 0.0023 0.0002 0.0008
Brugia malayi GnHR receptor homolog 0.0256 0.0188 0.0738
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0047 0.0021 0.0024
Schistosoma mansoni glutamate receptor NMDA 0.0039 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0026 0.0113
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0085 0.0052 0.0204
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0039 0.0015 0.0017
Echinococcus multilocularis glutamate receptor 2 0.0034 0.0011 0.0012
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0256 0.0188 0.0211
Echinococcus granulosus serine:threonine protein kinase 0.0237 0.0173 0.0194
Leishmania major beta tubulin 0.0023 0.0002 0.0006
Schistosoma mansoni hypothetical protein 0.0289 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0071
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0035 0.0012 0.0012
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0293 0.0218 0.0244
Echinococcus multilocularis collagen alpha 3(VI) chain 0.0043 0.0018 0.002
Echinococcus multilocularis Papilin 0.0043 0.0018 0.002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0256 0.0188 0.0211
Echinococcus multilocularis guanylate kinase 0.0021 0.0001 0.0001
Brugia malayi Kunitz/Bovine pancreatic trypsin inhibitor domain containing protein 0.0043 0.0018 0.0071
Loa Loa (eye worm) kunitz/Bovine pancreatic trypsin inhibitor domain-containing protein 0.0043 0.0018 0.0071
Onchocerca volvulus 0.0043 0.0018 0.077
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Brugia malayi putative neuropeptide receptor NPR1 0.0256 0.0188 0.0738
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.3211 0.2548 1
Schistosoma mansoni netrin receptor unc5 0.0031 0.0008 0.0008
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0146 0.01 0.0391
Trypanosoma cruzi cyclin, putative 0.0042 0.0017 0.0065
Loa Loa (eye worm) hypothetical protein 0.0046 0.0021 0.0081
Echinococcus granulosus death domain containing protein 0.0031 0.0008 0.0009
Chlamydia trachomatis transcriptional repressor NrdR 0.0425 0.0323 0.1268
Echinococcus multilocularis Ankyrin 0.0031 0.0008 0.0009
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0043 0.0018 0.0071
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0046 0.0021 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0256 0.0188 0.0188
Echinococcus granulosus glutamate receptor 2 0.0026 0.0005 0.0005
Schistosoma mansoni tubulin subunit beta 0.0023 0.0002 0.0002
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0039 0.0015 0.0017
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0057 0.003 0.0132
Trichomonas vaginalis tubulin gamma chain, putative 0.0023 0.0002 0.0007
Onchocerca volvulus 0.0043 0.0018 0.077
Schistosoma mansoni cell polarity protein 0.0077 0.0045 0.0045
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0256 0.0188 0.0188
Leishmania major UDP-galactopyranose mutase 0.0041 0.0017 0.0064
Brugia malayi hypothetical protein 0.0039 0.0015 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0026 0.0113
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.006
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0052 0.0026 0.0029
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0256 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0046 0.0021 0.0081
Trypanosoma brucei metacaspase MCA2 0.0052 0.0026 0.0098
Onchocerca volvulus Neuropeptide F receptor homolog 0.0256 0.0188 0.8055
Leishmania major beta tubulin 0.0023 0.0002 0.0006
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0017 0.0074
Trypanosoma brucei metacaspase 0.0052 0.0026 0.0098
Echinococcus multilocularis high voltage activated calcium channel beta 0.0021 0.0001 0.0001
Schistosoma mansoni neuropeptide F-like receptor 0.0256 0.0188 0.0188
Onchocerca volvulus 0.0256 0.0188 0.8055
Brugia malayi ribonucleotide reductase 2 0.0146 0.01 0.0393
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0026 0.0005 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.0071 0.032
Echinococcus granulosus regulator of G protein signaling 3 0.0035 0.0012 0.0013
Echinococcus multilocularis beta adrenergic receptor kinase 0.012 0.008 0.0089
Trypanosoma cruzi meiotic recombination protein DMC1, putative 0.0026 0.0005 0.0016
Schistosoma mansoni glutamate receptor AMPA 0.0034 0.0011 0.0011
Brugia malayi Transforming growth factor beta like domain containing protein 0.0063 0.0034 0.0135
Schistosoma mansoni caspase-7 (C14 family) 0.0174 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Loa Loa (eye worm) tubulin beta-4 chain 0.0023 0.0002 0.0008
Trichomonas vaginalis cyclins, putative 0.0042 0.0017 0.0075
Echinococcus granulosus cyclin B 0.0042 0.0017 0.0019
Giardia lamblia Beta tubulin 0.0023 0.0002 0.0182
Schistosoma mansoni serine-type protease inhibitor 0.0043 0.0018 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0256 0.0188 0.0211
Echinococcus granulosus integrin alpha ps 0.0091 0.0057 0.0063
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0313 0.0234 0.0234
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0269 0.0198 0.0778
Schistosoma mansoni amine GPCR 0.0256 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Echinococcus granulosus kelch ECH associated protein 1 0.0282 0.0209 0.0234
Schistosoma mansoni opsin-like receptor 0.0256 0.0188 0.0188
Echinococcus granulosus tissue type plasminogen activator 0.0145 0.01 0.0112
Schistosoma mansoni ankyrin 23/unc44 0.0031 0.0008 0.0008
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0085 0.0052 0.0058
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Brugia malayi Regulator of G protein signaling domain containing protein 0.0035 0.0012 0.0047
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0256 0.0188 0.0738
Onchocerca volvulus 0.0256 0.0188 0.8055
Mycobacterium ulcerans dehydrogenase 0.0041 0.0017 0.0076
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0052 0.0026 0.0098
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0035 0.0012 0.0052
Loa Loa (eye worm) guanylate kinase 0.0021 0.0001 0.0002
Onchocerca volvulus 0.0043 0.0018 0.077
Echinococcus granulosus WAP kazal immunoglobulin kunitz and NTR 0.0043 0.0018 0.002
Echinococcus granulosus caspase 2 0.0174 0.0123 0.0137
Echinococcus granulosus Ankyrin 0.0031 0.0008 0.0009
Echinococcus granulosus neuropeptides capa receptor 0.0256 0.0188 0.0211
Schistosoma mansoni tumor necrosis factor receptor related 0.0047 0.0021 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0012 0.0052
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0052 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0085 0.0052 0.0204
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0233 0.017 0.0668
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.3211 0.2548 0.2855
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0293 0.0218 0.0244
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0085 0.0052 0.0204
Echinococcus granulosus GPCR family 2 0.0289 0.0214 0.024
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0008 0.0033
Echinococcus granulosus collagen alpha 3(VI) chain 0.0043 0.0018 0.002
Leishmania major beta tubulin 0.0023 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0313 0.0234 0.0916
Echinococcus granulosus rhodopsin orphan GPCR 0.0256 0.0188 0.0211
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0039 0.0015 0.006
Schistosoma mansoni hypothetical protein 0.0113 0.0074 0.0074
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0256 0.0188 0.0188
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0386 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0071
Loa Loa (eye worm) hypothetical protein 0.0085 0.0052 0.0204
Onchocerca volvulus 0.0256 0.0188 0.8055
Brugia malayi hypothetical protein 0.0256 0.0188 0.0738
Entamoeba histolytica hypothetical protein 0.0071 0.004 1
Schistosoma mansoni serine-type protease inhibitor 1.1981 0.9552 0.9552
Schistosoma mansoni opsin-like receptor 0.0256 0.0188 0.0188
Echinococcus granulosus neuropeptide receptor 0.0256 0.0188 0.0211
Schistosoma mansoni patched 1 0.0109 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.006
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.2786 0.2209 1
Schistosoma mansoni z-protein (S1r protein) 0.0035 0.0012 0.0012
Onchocerca volvulus 0.0256 0.0188 0.8055
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0051 0.0025 0.0097
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0289 0.0214 0.024
Echinococcus granulosus somatostatin receptor 0.0256 0.0188 0.0211
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0002
Trypanosoma brucei metacaspase MCA3 0.0052 0.0026 0.0098
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0269 0.0198 0.0778
Echinococcus granulosus glycine receptor subunit alpha 1 0.0085 0.0052 0.0058
Loa Loa (eye worm) guanylate kinase 0.0063 0.0034 0.0135
Loa Loa (eye worm) hypothetical protein 0.0174 0.0123 0.0481
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0266 0.0196 0.0767
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0313 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0085 0.0052 0.0204
Echinococcus granulosus tubulin beta 1 chain 0.0023 0.0002 0.0002
Leishmania major metacaspase, putative 0.0052 0.0026 0.0098
Echinococcus granulosus rhodopsin orphan GPCR 0.0256 0.0188 0.0211
Echinococcus multilocularis G-protein coupled receptor, putative 0.0256 0.0188 0.0211
Schistosoma mansoni acetylcholine receptor-related 0.0039 0.0015 0.0015
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0233 0.017 0.0191
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.0425 0.0323 0.1463
Echinococcus multilocularis guanylate kinase 0.0021 0.0001 0.0001
Schistosoma mansoni mannosidase endo-alpha 0.0021 0.0001 0.0001
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0017 0.0067
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.006
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0071
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0031 0.0008 0.0009
Onchocerca volvulus 0.0256 0.0188 0.8055
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.3211 0.2548 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0015 0.006
Schistosoma mansoni maguk P55 subfamily member 26 0.0025 0.0004 0.0004
Plasmodium vivax aspartyl proteinase, putative 0.0386 0.0292 0.1143
Brugia malayi Kunitz/Bovine pancreatic trypsin inhibitor domain containing protein 0.0043 0.0018 0.0071
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0039 0.0015 0.0017
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0035 0.0012 0.0012
Onchocerca volvulus 0.0256 0.0188 0.8055
Schistosoma mansoni cell polarity protein 0.0029 0.0007 0.0007
Echinococcus granulosus MAGUK p55 subfamily 0.0025 0.0004 0.0004
Echinococcus granulosus SPONdin extracellular matrix glycoprotein 0.0043 0.0018 0.002
Brugia malayi regulator of G-protein signaling rgs-7 0.0035 0.0012 0.0047
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0035 0.0012 0.0047
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0313 0.0234 0.0234
Echinococcus multilocularis egf domain protein 0.0043 0.0018 0.002
Schistosoma mansoni amine oxidase 0.0041 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0256 0.0188 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0012 0.0052
Brugia malayi Integrin beta pat-3 precursor 0.0338 0.0254 0.0995
Brugia malayi hypothetical protein 0.0035 0.0012 0.0047
Schistosoma mansoni guanylate kinase 0.0021 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0224 0.0163 0.0163
Brugia malayi G protein-coupled receptor 0.0256 0.0188 0.0738
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0043 0.0018 0.0071
Schistosoma mansoni serine-type protease inhibitor 0.0043 0.0018 0.0018
Echinococcus granulosus tm gpcr rhodopsin 0.0256 0.0188 0.0211
Schistosoma mansoni neuropeptide receptor 0.0256 0.0188 0.0188
Echinococcus multilocularis dro:myosuppressin receptor 0.0256 0.0188 0.0211
Echinococcus granulosus rhodopsin orphan GPCR 0.0256 0.0188 0.0211
Toxoplasma gondii aspartyl protease ASP3 0.0392 0.0297 0.1163
Onchocerca volvulus Putative nachr subunit 0.0293 0.0218 0.9338
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.006
Echinococcus multilocularis tubulin beta 1 chain 0.0023 0.0002 0.0002
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0026 0.0113
Trypanosoma brucei proteasome beta 6 subunit 0.0057 0.003 0.0114
Loa Loa (eye worm) neuropeptide F receptor 0.0256 0.0188 0.0738
Echinococcus multilocularis Kunitz protease inhibitor 0.0043 0.0018 0.002
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0266 0.0196 0.0219
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0046 0.0021 0.0081
Echinococcus granulosus Protein patched homolog 1 0.0109 0.0071 0.008
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0151 0.0104 0.0117
Loa Loa (eye worm) glutamate receptor 2 0.0034 0.0011 0.0044
Echinococcus multilocularis g protein coupled receptor 0.0256 0.0188 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0026 0.0113
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0256 0.0188 0.0211
Plasmodium falciparum protoporphyrinogen oxidase 0.0041 0.0017 0.0064
Giardia lamblia Proteasome subunit beta type 1 0.0057 0.003 0.3519
Loa Loa (eye worm) kunitz/Bovine pancreatic trypsin inhibitor domain-containing protein 0.0043 0.0018 0.0071
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0039 0.0015 0.006
Echinococcus multilocularis integrin alpha ps 0.0044 0.0019 0.0021
Echinococcus granulosus g protein coupled receptor 0.0256 0.0188 0.0211
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0313 0.0234 0.0234
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0386 0.0292 0.0327
Brugia malayi G-protein coupled receptor 0.0256 0.0188 0.0738
Brugia malayi Integrin alpha pat-2 precursor 0.0091 0.0057 0.0222
Echinococcus granulosus sortilin 0.0136 0.0093 0.0104
Echinococcus granulosus rhodopsin orphan GPCR 0.0256 0.0188 0.0211
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0293 0.0218 0.0244
Echinococcus granulosus glutamate NMDA receptor subunit 0.0034 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Brugia malayi hypothetical protein 0.0039 0.0015 0.006
Trypanosoma brucei beta tubulin 0.0023 0.0002 0.0006
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0008 0.0033
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0052 0.0204
Leishmania major beta tubulin 0.0023 0.0002 0.0006
Schistosoma mansoni tubulin subunit beta 0.0023 0.0002 0.0002
Leishmania major cyclin 0.0042 0.0017 0.0065
Echinococcus granulosus tm gpcr rhodopsin 1.1195 0.8924 1
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Onchocerca volvulus Papilin homolog 0.0043 0.0018 0.077
Schistosoma mansoni neurotransmitter gated ion channel 0.0039 0.0015 0.0015
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.3211 0.2548 1
Echinococcus multilocularis protein dispatched 1 0.0109 0.0071 0.008
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.0017 0.0064
Echinococcus multilocularis serine:threonine protein kinase 0.0237 0.0173 0.0194
Onchocerca volvulus Papilin homolog 0.0043 0.0018 0.077
Loa Loa (eye worm) hypothetical protein 0.0151 0.0104 0.0409
Loa Loa (eye worm) hypothetical protein 0.0085 0.0052 0.0204
Toxoplasma gondii beta-tubulin, putative 0.0023 0.0002 0.0006
Echinococcus multilocularis caspase 8 0.0052 0.0026 0.0029
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0057 0.003 0.0114
Echinococcus granulosus Kunitz protease inhibitor 0.0043 0.0018 0.002
Trichomonas vaginalis tubulin, putative 0.0023 0.0002 0.0007
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0085 0.0052 0.0052
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0063 0.0034 0.0039
Loa Loa (eye worm) hypothetical protein 0.0035 0.0012 0.0047
Loa Loa (eye worm) ACC-1 protein 0.0085 0.0052 0.0204
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Echinococcus granulosus Papilin 0.0043 0.0018 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0256 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Echinococcus multilocularis collagen alpha 1(XXVIII) chain 0.0043 0.0018 0.002
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0085 0.0052 0.0204
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.004 0.0045
Loa Loa (eye worm) integrin beta-2 0.0338 0.0254 0.0995
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0012 0.0052
Toxoplasma gondii sortilin, putative 0.0136 0.0093 0.0361
Echinococcus granulosus trypsin inhibitor 0.0043 0.0018 0.002
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0266 0.0196 0.0767
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Plasmodium falciparum plasmepsin IX 0.0392 0.0297 0.1163
Loa Loa (eye worm) hypothetical protein 0.0046 0.0021 0.0081
Echinococcus granulosus WAP, kazal, immunoglobulin, kunitz and NTR 0.0043 0.0018 0.002
Brugia malayi putative neuropeptide receptor 0.0256 0.0188 0.0738
Schistosoma mansoni biogenic amine (5HT) receptor 0.0256 0.0188 0.0188
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0256 0.0188 0.0738
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Echinococcus multilocularis SPONdin (extracellular matrix glycoprotein) 0.0043 0.0018 0.002
Onchocerca volvulus 0.0043 0.0018 0.077
Plasmodium vivax hypothetical protein, conserved 0.0052 0.0026 0.0098
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.3211 0.2548 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0313 0.0234 0.0234
Mycobacterium tuberculosis Possible oxidoreductase 0.0041 0.0017 0.0074
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0256 0.0188 0.0211
Echinococcus multilocularis rhodopsin orphan GPCR 0.0256 0.0188 0.0211
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.006
Schistosoma mansoni myosin xvIII 0.0256 0.0188 0.0188
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0052 0.0204
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0256 0.0188 0.0211
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0049 0.0023 0.0089
Onchocerca volvulus 0.0042 0.0017 0.0733
Echinococcus granulosus beta-adrenergic receptor kinase 0.012 0.008 0.0089
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.004 0.0045
Echinococcus granulosus Papilin 0.0043 0.0018 0.002
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0085 0.0052 0.0204
Loa Loa (eye worm) hypothetical protein 0.0085 0.0052 0.0204
Schistosoma mansoni ATP-binding cassette transporter 0.0034 0.0011 0.0011
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0039 0.0015 0.0017
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0047 0.0021 0.0024
Loa Loa (eye worm) hypothetical protein 0.0031 0.0008 0.0033
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0289 0.0214 0.024
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.3211 0.2548 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0256 0.0188 0.0188
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0146 0.01 0.0391
Echinococcus multilocularis rhodopsin orphan GPCR 0.0256 0.0188 0.0211
Trichomonas vaginalis tubulin epsilon chain, putative 0.0023 0.0002 0.0007
Echinococcus granulosus neuropeptide s receptor 0.0256 0.0188 0.0211
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0039 0.0015 0.0017
Loa Loa (eye worm) hypothetical protein 0.0085 0.0052 0.0204
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0041 0.0017 0.0064
Echinococcus granulosus nAChR subunit 0.0046 0.0021 0.0023
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.0025 0.0004 0.0004
Echinococcus granulosus sterol regulatory element binding protein 0.0109 0.0071 0.008
Brugia malayi hypothetical protein 0.0041 0.0017 0.0066
Schistosoma mansoni serine-type protease inhibitor 0.0043 0.0018 0.0018
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0146 0.01 0.0391
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0256 0.0188 0.0211
Loa Loa (eye worm) kunitz/Bovine pancreatic trypsin inhibitor domain-containing protein 0.0043 0.0018 0.0071
Schistosoma mansoni growth hormone secretagogue receptor 0.0256 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0151 0.0104 0.0409
Brugia malayi hypothetical protein 0.0256 0.0188 0.0738
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0021 0.0001 0.0002
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0146 0.01 0.0391
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0057 0.003 0.003
Schistosoma mansoni cathepsin D (A01 family) 0.0664 0.0514 0.0514
Echinococcus granulosus regulator of G protein signaling 7 0.0035 0.0012 0.0013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0913 0.0713 0.2796
Brugia malayi Cation transporter family protein 0.0085 0.0052 0.0204
Brugia malayi neuropeptide F receptor 0.0256 0.0188 0.0738
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Plasmodium falciparum plasmepsin V 0.0313 0.0234 0.0914
Brugia malayi Calcitonin receptor-like protein seb-1 0.0913 0.0713 0.2796
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0071
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.0127 0.0127
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0256 0.0188 0.0211
Schistosoma mansoni tubulin subunit beta 0.0023 0.0002 0.0002
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0256 0.0188 0.0188
Trichomonas vaginalis cyclin B, putative 0.0042 0.0017 0.0075
Loa Loa (eye worm) hypothetical protein 0.0085 0.0052 0.0204
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0266 0.0196 0.0887
Loa Loa (eye worm) hypothetical protein 0.0085 0.0052 0.0204
Chlamydia trachomatis protoporphyrinogen oxidase 0.0041 0.0017 0.0064
Brugia malayi hypothetical protein 0.0256 0.0188 0.0738
Schistosoma mansoni nAChR subunit 0.0085 0.0052 0.0052
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0256 0.0188 0.0211
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0293 0.0218 0.0244
Plasmodium falciparum plasmepsin VIII, putative 0.0313 0.0234 0.0914
Echinococcus granulosus G protein coupled receptor 139 0.0256 0.0188 0.0211
Echinococcus multilocularis netrin receptor unc 5 0.0031 0.0008 0.0009
Entamoeba histolytica hypothetical protein 0.0035 0.0012 0.2883
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0026 0.0113
Loa Loa (eye worm) hypothetical protein 0.0256 0.0188 0.0738
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0125 0.0083 1
Onchocerca volvulus 0.0256 0.0188 0.8055
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0071
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0035 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.006
Echinococcus multilocularis myosin light chain kinase, smooth muscle 0.0237 0.0173 0.0194
Brugia malayi guanylate kinase 0.0021 0.0001 0.0002
Plasmodium falciparum cysteine repeat modular protein 1 0.0145 0.01 0.0389
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0052 0.0026 0.0029
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0125 0.0083 0.0375
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0266 0.0196 0.0767
Schistosoma mansoni tubulin subunit beta 0.0023 0.0002 0.0002
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0256 0.0188 0.0738
Plasmodium vivax metacaspase 1, putative 0.0052 0.0026 0.0098
Schistosoma mansoni hypothetical protein 0.0071 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0256 0.0188 0.0188
Leishmania major beta tubulin 0.0023 0.0002 0.0006
Echinococcus multilocularis expressed protein 0.0043 0.0018 0.002
Leishmania major beta tubulin 0.0023 0.0002 0.0006
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0146 0.01 0.0112
Echinococcus granulosus allatostatin A receptor 0.0256 0.0188 0.0211
Echinococcus multilocularis neuropeptide receptor 0.085 0.0662 0.0742
Giardia lamblia Beta tubulin 0.0023 0.0002 0.0182
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0085 0.0052 0.0058
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0052 0.0204
Echinococcus granulosus serotonin receptor 0.0256 0.0188 0.0211
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0256 0.0188 0.0188
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0256 0.0188 0.0188
Schistosoma mansoni hypothetical protein 0.0033 0.001 0.001
Echinococcus granulosus Kunitz:Bovine pancreatic trypsin inhibitor 0.0043 0.0018 0.002
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0146 0.01 0.0393
Echinococcus granulosus receptor type guanylyl cyclase 0.0026 0.0005 0.0005
Brugia malayi Cation transporter family protein 0.0085 0.0052 0.0204
Trypanosoma brucei beta tubulin 0.0023 0.0002 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0256 0.0188 0.0188
Schistosoma mansoni biogenic amine receptor 0.0256 0.0188 0.0188
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0052 0.0204
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0035 0.0012 0.0012
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0057 0.003 0.0114
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0041 0.0017 0.0076
Plasmodium falciparum plasmepsin I 0.0386 0.0292 0.1143
Echinococcus granulosus collagen alpha 1XXVIII chain 0.0043 0.0018 0.002
Loa Loa (eye worm) tubulin beta-1 chain 0.0023 0.0002 0.0008
Leishmania major beta tubulin 0.0023 0.0002 0.0006
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0256 0.0188 0.0738
Brugia malayi hypothetical protein 0.0256 0.0188 0.0738
Brugia malayi Protein kinase domain containing protein 0.0146 0.0101 0.0395
Echinococcus granulosus guanylate kinase 0.0021 0.0001 0.0001
Brugia malayi Kunitz/Bovine pancreatic trypsin inhibitor domain containing protein 0.0043 0.0018 0.0071
Brugia malayi regulator of G-protein signaling egl-10 0.0035 0.0012 0.0047
Schistosoma mansoni serine-type protease inhibitor 0.0043 0.0018 0.0018
Leishmania major beta tubulin 0.0023 0.0002 0.0006
Echinococcus multilocularis regulator of G protein signaling 7 0.0035 0.0012 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0269 0.0198 0.0198
Echinococcus granulosus neuropeptide Y receptor 0.0256 0.0188 0.0211

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 100.3 ug ml-1 Cytotoxicity against C8166 cells after 72 hrs by MTT method ChEMBL. 17489633
CC50 (ADMET) = 100.3 ug ml-1 Cytotoxicity against C8166 cells after 72 hrs by MTT method ChEMBL. 17489633
EC50 (functional) = 16.2 ug ml-1 Antiviral activity against HIV1 3B in C8166 cells ChEMBL. 17489633

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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