Detailed information for compound 460302

Basic information

Technical information
  • TDR Targets ID: 460302
  • Name: N-[(2S)-1-amino-3-phenylpropan-2-yl]-2-[(2-me thylcyclopropyl)methylamino]-6-[methyl(methyl sulfonyl)amino]pyridine-4-carboxamide
  • MW: 445.578 | Formula: C22H31N5O3S
  • H donors: 3 H acceptors: 4 LogP: 2.19 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC[C@@H](NC(=O)c1cc(NCC2CC2C)nc(c1)N(S(=O)(=O)C)C)Cc1ccccc1
  • InChi: 1S/C22H31N5O3S/c1-15-9-18(15)14-24-20-11-17(12-21(26-20)27(2)31(3,29)30)22(28)25-19(13-23)10-16-7-5-4-6-8-16/h4-8,11-12,15,18-19H,9-10,13-14,23H2,1-3H3,(H,24,26)(H,25,28)/t15?,18?,19-/m0/s1
  • InChiKey: YVDYUARNOWTGPV-PPSBMQLTSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(1S)-1-(aminomethyl)-2-phenyl-ethyl]-2-[(2-methylcyclopropyl)methylamino]-6-[methyl(methylsulfonyl)amino]pyridine-4-carboxamide
  • N-[(1S)-1-(aminomethyl)-2-phenylethyl]-2-[(2-methylcyclopropyl)methylamino]-6-[methyl(methylsulfonyl)amino]-4-pyridinecarboxamide
  • N-[(2S)-1-azanyl-3-phenyl-propan-2-yl]-2-[(2-methylcyclopropyl)methylamino]-6-[methyl(methylsulfonyl)amino]pyridine-4-carboxamide
  • N-[(1S)-1-(aminomethyl)-2-phenyl-ethyl]-2-[mesyl(methyl)amino]-6-[(2-methylcyclopropyl)methylamino]isonicotinamide
  • N-[(2S)-1-amino-3-phenylpropan-2-yl]-2-[(2-methylcyclopropyl)methylamino]-6-(methyl-methylsulfonylamino)pyridine-4-carboxamide
  • N-[(1S)-1-(aminomethyl)-2-phenyl-ethyl]-2-[(2-methylcyclopropyl)methylamino]-6-(methyl-methylsulfonyl-amino)pyridine-4-carboxamide
  • N-[(1S)-1-(aminomethyl)-2-phenylethyl]-2-[(2-methylcyclopropyl)methylamino]-6-(methyl-methylsulfonylamino)-4-pyridinecarboxamide
  • N-[(1S)-1-(aminomethyl)-2-phenyl-ethyl]-2-(mesyl-methyl-amino)-6-[(2-methylcyclopropyl)methylamino]isonicotinamide
  • N-[(2S)-1-amino-3-phenyl-propan-2-yl]-2-[(2-methylcyclopropyl)methylamino]-6-(methyl-methylsulfonyl-amino)pyridine-4-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens beta-site APP-cleaving enzyme 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni memapsin-2 (A01 family) Get druggable targets OG5_135830 All targets in OG5_135830
Schistosoma japonicum ko:K07747 beta-site APP-cleaving enzyme 2 (memapsin 1) [EC3.4.23.45], putative Get druggable targets OG5_135830 All targets in OG5_135830
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum plasmepsin VII beta-site APP-cleaving enzyme 1 401 aa 352 aa 21.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0223 0.0705
Schistosoma mansoni growth hormone secretagogue receptor 0.0058 0.0153 0.0153
Trypanosoma brucei Calpain-like protein 1.2 0.0053 0.012 0.038
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0058 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0053 0.012 0.012
Brugia malayi putative neuropeptide receptor NPR1 0.0058 0.0153 0.0153
Brugia malayi hypothetical protein 0.0234 0.1319 0.1319
Onchocerca volvulus 0.0058 0.0153 0.0787
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.005 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Entamoeba histolytica cysteine proteinase, putative 0.0058 0.0149 0.0934
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0223 0.0705
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0053 0.012 0.038
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0099 0.0314
Brugia malayi cathepsin F-like cysteine proteinase 0.005 0.0099 0.0099
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0236 0.0236
Loa Loa (eye worm) calpain 5 0.0124 0.0591 0.0591
Schistosoma mansoni immunophilin 0.0276 0.1599 0.1599
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0177 0.0946 0.2992
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0017 0.0017
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0475 0.0475
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0153 0.0153
Trichomonas vaginalis caltractin, putative 0.0048 0.0081 0.0257
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0153 0.0153
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0201 0.0201
Echinococcus granulosus cysteine protease 0.0058 0.0149 0.0149
Entamoeba histolytica cysteine protease, putative 0.0058 0.0149 0.0934
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0177 0.0946 0.0946
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0053 0.012 0.012
Echinococcus granulosus calpain 5 0.0177 0.0946 0.0946
Toxoplasma gondii EF hand domain-containing protein 0.0048 0.0081 0.0257
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0497 0.0497
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0053 0.012 0.038
Echinococcus granulosus geminin 0.0521 0.323 0.323
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0276 0.1599 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Leishmania major calpain family cysteine protease-like protein 0.0053 0.012 0.038
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0053 0.012 0.038
Entamoeba histolytica cysteine protease, putative 0.0069 0.0223 0.1394
Entamoeba histolytica calpain large subunit domain III containing protein 0.0124 0.0591 0.3696
Brugia malayi hypothetical protein 0.0058 0.0153 0.0153
Echinococcus granulosus programmed cell death protein 0.0079 0.0289 0.0289
Entamoeba histolytica hypothetical protein 0.011 0.0498 0.3114
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0149 0.0149
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0223 0.0705
Onchocerca volvulus 0.0069 0.0223 0.1191
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0056 0.0056
Schistosoma mansoni chromobox protein 0.0073 0.0248 0.0248
Brugia malayi Neuronal calcium sensor family protein 1 0.0048 0.0081 0.0081
Leishmania major hypothetical protein, unknown function 0.0053 0.012 0.038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0223 0.0705
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0005 0.0005
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0201 0.0201
Onchocerca volvulus 0.0069 0.0223 0.1191
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0082 0.0082
Echinococcus multilocularis programmed cell death protein 6 0.0048 0.0081 0.0081
Echinococcus granulosus neuropeptides capa receptor 0.0058 0.0153 0.0153
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0449 0.1421
Plasmodium falciparum serine repeat antigen 7 0.005 0.0099 0.0517
Echinococcus granulosus cathepsin l1 0.0061 0.0173 0.0173
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0223 0.0223
Plasmodium vivax serine-repeat antigen (SERA) 0.005 0.0099 0.0517
Loa Loa (eye worm) G-protein coupled receptor 0.0058 0.0153 0.0153
Brugia malayi beta-lactamase 0.011 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0156 0.0804 0.0804
Echinococcus granulosus neuropeptide Y receptor 0.0058 0.0153 0.0153
Echinococcus granulosus chromobox protein 1 0.0073 0.0248 0.0248
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0099 0.0314
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0058 0.0153 0.0153
Schistosoma mansoni calpain (C02 family) 0.0177 0.0946 0.0946
Entamoeba histolytica cysteine protease, putative 0.005 0.0099 0.0621
Loa Loa (eye worm) melatonin receptor type 1A 0.0058 0.0153 0.0153
Trypanosoma cruzi cysteine protease, putative 0.0058 0.0149 0.0149
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0058 0.0149 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0223 0.0705
Echinococcus granulosus neuropeptide FF receptor 2 0.0058 0.0153 0.0153
Schistosoma mansoni fk506 binding protein 0.0038 0.0017 0.0017
Echinococcus granulosus g protein coupled receptor 0.0058 0.0153 0.0153
Trypanosoma cruzi kinesin, putative 0.0124 0.0591 0.0591
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0058 0.0153 0.0153
Echinococcus multilocularis neuropeptide s receptor 0.0537 0.334 0.334
Brugia malayi Tachykinin-like peptides receptor 99D 0.0058 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0223 0.0705
Loa Loa (eye worm) hypothetical protein 0.0044 0.0056 0.0056
Onchocerca volvulus 0.0058 0.0153 0.0787
Schistosoma mansoni hypothetical protein 0.0049 0.0094 0.0094
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0276 0.1599 0.1599
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.038
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0005 0.0005
Onchocerca volvulus 0.0048 0.0081 0.0369
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0005 0.0005
Trichomonas vaginalis fk506-binding protein, putative 0.0038 0.0017 0.0055
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0502 0.3104 0.3104
Giardia lamblia Cathepsin B precursor 0.005 0.0099 0.0298
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0449 0.0449
Schistosoma mansoni biogenic amine receptor 0.0058 0.0153 0.0153
Echinococcus granulosus serotonin receptor 0.0058 0.0153 0.0153
Plasmodium falciparum centrin-4 0.0048 0.0081 0.0403
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.005 0.0099 0.0298
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0497 0.1571
Brugia malayi hypothetical protein 0.0058 0.0153 0.0153
Schistosoma mansoni amine GPCR 0.0058 0.0153 0.0153
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.005 0.0099 0.0517
Giardia lamblia Cysteine protease 0.005 0.0099 0.0298
Plasmodium falciparum serine repeat antigen 4 0.005 0.0099 0.0517
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.038
Echinococcus granulosus biogenic amine 5HT receptor 0.0058 0.0153 0.0153
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0082 0.0082
Brugia malayi Papain family cysteine protease containing protein 0.0058 0.0149 0.0149
Trichomonas vaginalis calpain, putative 0.0053 0.012 0.038
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0069 0.0223 0.0223
Echinococcus multilocularis chromobox protein 1 0.0073 0.0248 0.0248
Schistosoma mansoni hypothetical protein 0.0042 0.0046 0.0046
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0005 0.0005
Echinococcus granulosus calpain 0.0177 0.0946 0.0946
Leishmania major cathepsin L-like protease 0.0069 0.0223 0.0705
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0223 0.0223
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0102 0.0443 0.0443
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0099 0.0099
Brugia malayi cathepsin L-like cysteine proteinase 0.005 0.0099 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0149 0.0473
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0058 0.0153 0.0153
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0053 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0248 0.0783
Entamoeba histolytica cysteine proteinase, putative 0.0058 0.0149 0.0934
Toxoplasma gondii calcium binding protein precursor, putative 0.0048 0.0081 0.0257
Trypanosoma brucei cysteine peptidase C (CPC) 0.051 0.3161 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Brugia malayi Cathepsin L-like precursor 0.0069 0.0223 0.0223
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0058 0.0153 0.0153
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0443 0.0443
Loa Loa (eye worm) hypothetical protein 0.0036 0.0005 0.0005
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0276 0.1599 0.1599
Echinococcus granulosus GPCR family 2 0.0049 0.0094 0.0094
Trypanosoma brucei calpain, putative 0.0053 0.012 0.038
Entamoeba histolytica protein kinase, putative 0.0125 0.0597 0.3735
Brugia malayi Cathepsin L-like precursor 0.0069 0.0223 0.0223
Loa Loa (eye worm) calpain family protein 1 0.0346 0.207 0.207
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.0153 0.0153
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0177 0.0946 0.0946
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.038
Echinococcus granulosus cathepsin b 0.1538 1 1
Trypanosoma brucei calpain-like protein, putative 0.0177 0.0946 0.2992
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0058 0.0153 0.0153
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.005 0.0099 0.0099
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0201 0.0201
Brugia malayi putative neuropeptide receptor 0.0058 0.0153 0.0153
Giardia lamblia Cathepsin L precursor 0.005 0.0099 0.0298
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0223 0.0223
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0053 0.012 0.038
Echinococcus multilocularis 0.0038 0.0017 0.0017
Toxoplasma gondii cathepsin B 0.051 0.3161 1
Brugia malayi Serotonin receptor 0.0058 0.0153 0.0153
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.005 0.0099 0.0099
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Brugia malayi neuropeptide F receptor 0.0058 0.0153 0.0153
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1538 1 1
Plasmodium vivax serine-repeat antigen (SERA) 0.005 0.0099 0.0517
Schistosoma mansoni chromobox protein 0.0073 0.0248 0.0248
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0276 0.1599 0.1599
Entamoeba histolytica cysteine protease, putative 0.005 0.0099 0.0621
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0103 0.0449 0.1421
Trichomonas vaginalis calpain, putative 0.0053 0.012 0.038
Echinococcus granulosus cathepsin l cysteine peptidase 0.0069 0.0223 0.0223
Brugia malayi hypothetical protein 0.0297 0.1742 0.1742
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.0099 0.0314
Leishmania major calpain protease-like protein 0.0053 0.012 0.038
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.005 0.0099 0.0517
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0201 0.0201
Giardia lamblia Cysteine protease 0.005 0.0099 0.0298
Brugia malayi follicle stimulating hormone receptor 0.0058 0.0153 0.0153
Entamoeba histolytica cysteine protease, putative 0.0058 0.0149 0.0934
Schistosoma mansoni immunophilin 0.0238 0.1347 0.1347
Echinococcus multilocularis mitogen activated protein kinase 3 0.0103 0.0449 0.0449
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0223 0.0705
Leishmania major cathepsin L-like protease 0.0069 0.0223 0.0705
Loa Loa (eye worm) fibroinase 0.0069 0.0223 0.0223
Onchocerca volvulus 0.0069 0.0223 0.1191
Echinococcus multilocularis g protein coupled receptor 0.0058 0.0153 0.0153
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0082 0.0082
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.005 0.0099 0.0099
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0058 0.0153 0.0153
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0058 0.0153 0.0153
Schistosoma mansoni calpain-7 (C02 family) 0.018 0.0965 0.0965
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0276 0.1599 0.1599
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Brugia malayi Cathepsin L-like precursor 0.0069 0.0223 0.0223
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0177 0.0946 0.0946
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0497 0.0497
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0048 0.0081 0.0369
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.0173 0.108
Echinococcus granulosus calcyphosin protein 0.0048 0.0081 0.0081
Brugia malayi hypothetical protein 0.011 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0223 0.0705
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.038
Loa Loa (eye worm) TYRA-2 protein 0.0058 0.0153 0.0153
Onchocerca volvulus 0.0297 0.1742 1
Giardia lamblia Cathepsin B precursor 0.005 0.0099 0.0298
Echinococcus granulosus dro:myosuppressin receptor 0.0058 0.0153 0.0153
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0824 0.0824
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0153 0.0153
Echinococcus multilocularis mitogen activated protein kinase 0.0103 0.0449 0.0449
Trichomonas vaginalis fk506-binding protein, putative 0.0276 0.1599 0.5058
Loa Loa (eye worm) hypothetical protein 0.005 0.0099 0.0099
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0497 0.0497
Entamoeba histolytica calpain family cysteine protease, putative 0.0053 0.012 0.0751
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0173 0.0546
Entamoeba histolytica cysteine proteinase, putative 0.0069 0.0223 0.1394
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0177 0.0946 0.2992
Entamoeba histolytica hypothetical protein 0.005 0.0099 0.0621
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0276 0.1599 0.1599
Toxoplasma gondii hypothetical protein 0.0053 0.012 0.038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0223 0.0705
Echinococcus multilocularis fmrfamide receptor 0.0058 0.0153 0.0153
Giardia lamblia Dipeptidyl-peptidase I precursor 0.005 0.0099 0.0298
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0497 0.1084
Onchocerca volvulus 0.0058 0.0153 0.0787
Loa Loa (eye worm) hypothetical protein 0.0054 0.0122 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0223 0.0705
Schistosoma mansoni myosin regulatory light chain 0.0048 0.0081 0.0081
Schistosoma mansoni patched 1 0.0044 0.0056 0.0056
Echinococcus multilocularis protein patched 0.0044 0.0056 0.0056
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0058 0.0153 0.0153
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.005 0.0099 0.0517
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0824 0.0824
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0498 0.0498
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0005 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0223 0.0705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0223 0.0705
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0201 0.0201
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0058 0.0153 0.0153
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0041 0.0036 0.0036
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0449 0.1421
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Trichomonas vaginalis centrin, putative 0.0048 0.0081 0.0257
Loa Loa (eye worm) hypothetical protein 0.011 0.0497 0.0497
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0038 0.0017 0.0017
Giardia lamblia Cathepsin L-like protease 0.005 0.0099 0.0298
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.005 0.0099 0.0517
Brugia malayi Myosin regulatory light chain 1 0.0048 0.0081 0.0081
Loa Loa (eye worm) neuropeptide F receptor 0.0058 0.0153 0.0153
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0058 0.0153 0.0153
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1538 1 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0497 0.1084
Leishmania major hypothetical protein, conserved 0.011 0.0497 0.1571
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0099 0.0314
Trypanosoma brucei calpain-like protein, putative 0.0177 0.0946 0.2992
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Entamoeba histolytica cysteine proteinase, putative 0.0058 0.0149 0.0934
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.0099 0.0314
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0005 0.0005
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0276 0.1599 0.5058
Brugia malayi calpain 5 0.0053 0.012 0.012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0082 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.005 0.0099 0.0314
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0497 0.1571
Loa Loa (eye worm) FKBP5 protein 0.0276 0.1599 0.1599
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.012
Entamoeba histolytica cysteine protease, putative 0.0058 0.0149 0.0934
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0081 0.0257
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0223 0.0705
Schistosoma mansoni hypothetical protein 0.0053 0.012 0.012
Brugia malayi hypothetical protein 0.0058 0.0153 0.0153
Giardia lamblia Dipeptidyl-peptidase I precursor 0.005 0.0099 0.0298
Schistosoma mansoni cathepsin F (C01 family) 0.0061 0.0173 0.0173
Trichomonas vaginalis centrin, putative 0.0048 0.0081 0.0257
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Onchocerca volvulus 0.0048 0.0081 0.0369
Giardia lamblia Cathepsin B precursor 0.005 0.0099 0.0298
Loa Loa (eye worm) hypothetical protein 0.0038 0.0017 0.0017
Brugia malayi Serotonin receptor 0.0058 0.0153 0.0153
Giardia lamblia Cathepsin B precursor 0.005 0.0099 0.0298
Schistosoma mansoni alpha-glucosidase 0.0137 0.0676 0.0676
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0056 0.0178
Leishmania major peptidylprolyl isomerase-like protein 0.0276 0.1599 0.5058
Echinococcus granulosus calpain A 0.0502 0.3104 0.3104
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Trypanosoma brucei Calpain-like protein 2 0.0053 0.012 0.038
Onchocerca volvulus 0.0058 0.0153 0.0787
Onchocerca volvulus 0.0048 0.0082 0.0375
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0038 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Mycobacterium leprae Probable lipase LipE 0.011 0.0497 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0058 0.0153 0.0153
Schistosoma mansoni hypothetical protein 0.0042 0.0046 0.0046
Brugia malayi Melatonin receptor type 1A 0.0058 0.0153 0.0153
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0053 0.012 0.012
Onchocerca volvulus 0.0058 0.0153 0.0787
Trichomonas vaginalis centrin, putative 0.0048 0.0081 0.0257
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0177 0.0946 0.0946
Schistosoma mansoni hypothetical protein 0.0058 0.0153 0.0153
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.0099 0.0099
Trypanosoma brucei protein kinase, putative 0.0103 0.0449 0.1421
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0703 0.444 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0058 0.0153 0.0153
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.0734 0.0734
Brugia malayi hypothetical protein 0.0058 0.0153 0.0153
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0053 0.012 0.012
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.038
Trypanosoma brucei kinesin, putative 0.0124 0.0591 0.1869
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Onchocerca volvulus 0.0058 0.0153 0.0787
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0056 0.0056
Entamoeba histolytica grainin 2 0.0048 0.0081 0.0508
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0502 0.3104 0.3104
Echinococcus multilocularis cathepsin L cysteine protease 0.0069 0.0223 0.0223
Giardia lamblia Dipeptidyl-peptidase I precursor 0.005 0.0099 0.0298
Brugia malayi sulfakinin receptor protein 0.0058 0.0153 0.0153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0149 0.0473
Giardia lamblia Cysteine protease 0.005 0.0099 0.0298
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0238 0.1347 0.1347
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.0099 0.0314
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0276 0.1599 0.5058
Giardia lamblia Cathepsin B precursor 0.051 0.3161 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0099 0.0314
Brugia malayi AKH receptor 0.0058 0.0153 0.0153
Echinococcus multilocularis cathepsin b 0.1538 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0058 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0107 0.0475 0.0475
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.038
Mycobacterium tuberculosis Conserved protein 0.011 0.0497 0.1084
Trypanosoma brucei calpain-like protein, putative 0.0177 0.0946 0.2992
Echinococcus granulosus tm gpcr rhodopsin 0.0058 0.0153 0.0153
Schistosoma mansoni alpha-glucosidase 0.0137 0.0676 0.0676
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.005 0.0099 0.0517
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0497 0.1571
Giardia lamblia Calmodulin 0.0048 0.0081 0.024
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0036 0.0105
Toxoplasma gondii cathepsin CPC2 0.005 0.0099 0.0314
Onchocerca volvulus Neuropeptide F receptor homolog 0.0058 0.0153 0.0787
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0053 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Entamoeba histolytica cysteine proteinase, putative 0.0069 0.0223 0.1394
Onchocerca volvulus 0.0058 0.0153 0.0787
Entamoeba histolytica cysteine protease, putative 0.0058 0.0149 0.0934
Entamoeba histolytica papain family cysteine protease domain containing protein 0.005 0.0099 0.0621
Brugia malayi Fli-1 protein 0.0215 0.1194 0.1194
Schistosoma mansoni neuropeptide receptor 0.0058 0.0153 0.0153
Leishmania major cathepsin L-like protease 0.0069 0.0223 0.0705
Loa Loa (eye worm) hypothetical protein 0.011 0.0497 0.0497
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0038 0.0017 0.0017
Entamoeba histolytica cysteine protease, putative 0.0058 0.0149 0.0934
Trichomonas vaginalis esterase, putative 0.011 0.0497 0.1571
Brugia malayi Ets-domain containing protein 0.0071 0.0236 0.0236
Onchocerca volvulus 0.011 0.0497 0.2779
Giardia lamblia Cathepsin B precursor 0.005 0.0099 0.0298
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Echinococcus granulosus tar DNA binding protein 0.0066 0.0201 0.0201
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.005 0.0099 0.0314
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0099 0.0314
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0005 0.0005
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.012
Trypanosoma cruzi centrin-3 0.0079 0.0289 0.0289
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0099 0.0099
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0497 0.1084
Echinococcus multilocularis Myosin regulatory light chain 0.0048 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0049 0.0094 0.0094
Loa Loa (eye worm) G-protein coupled receptor 0.0058 0.0153 0.0153
Echinococcus multilocularis calcyphosin protein 0.0048 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.011 0.0498 0.0498
Onchocerca volvulus 0.0058 0.0153 0.0787
Echinococcus granulosus mitogen activated protein kinase 0.0103 0.0449 0.0449
Echinococcus multilocularis calpain 7 (C02 family) 0.0177 0.0946 0.0946
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0094 0.0094
Schistosoma mansoni cathepsin F (C01 family) 0.0069 0.0223 0.0223
Onchocerca volvulus 0.0058 0.0153 0.0787
Brugia malayi hypothetical protein 0.0058 0.0153 0.0153
Echinococcus multilocularis fmrfamide receptor 0.0058 0.0153 0.0153
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0038 0.0017 0.0017
Echinococcus granulosus hypothetical protein 0.0058 0.0153 0.0153
Echinococcus multilocularis G-protein coupled receptor, putative 0.0058 0.0153 0.0153
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0058 0.0153 0.0153
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0038 0.0017 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0497 0.0497
Leishmania major hypothetical protein, conserved 0.0053 0.012 0.038
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0276 0.1599 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0082 0.0082
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0069 0.0223 0.0223
Echinococcus multilocularis calpain A 0.0502 0.3104 0.3104
Echinococcus multilocularis cysteine protease 0.0069 0.0223 0.0223
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0794 0.5044 0.5044
Echinococcus granulosus 7TM GPCR rhodopsin 0.0058 0.0153 0.0153
Echinococcus multilocularis cathepsin L cysteine protease 0.0069 0.0223 0.0223
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0497 0.3031
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0038 0.0017 0.0017
Echinococcus granulosus g-protein coupled receptor 0.0058 0.0153 0.0153
Echinococcus granulosus G protein coupled receptor 139 0.0058 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.051 0.3161 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.005 0.0099 0.0314
Echinococcus multilocularis cathepsin b 0.1538 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0058 0.0153 0.0153
Entamoeba histolytica cysteine protease, putative 0.005 0.0099 0.0621
Schistosoma mansoni myosin light chain 0.0048 0.0081 0.0081
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0099 0.0099
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0058 0.0153 0.0153
Schistosoma mansoni neuropeptide f receptor 76f 0.0058 0.0153 0.0153
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.005 0.0099 0.0517
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0201 0.0201
Schistosoma mansoni amine GPCR 0.0058 0.0153 0.0153
Trichomonas vaginalis fk506 binding protein, putative 0.0038 0.0017 0.0055
Entamoeba histolytica cysteine proteinase 1, putative 0.0058 0.0149 0.0934
Brugia malayi G-protein coupled receptor 0.0058 0.0153 0.0153
Brugia malayi G protein-coupled receptor 0.0058 0.0153 0.0153
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0017 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.038
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.005 0.0099 0.0099
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0153 0.0153
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0103 0.0449 0.0449
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0497 0.1571
Brugia malayi cathepsin Z-like cysteine proteinase 0.005 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.011 0.0497 0.0497
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 0.0153 0.0153
Echinococcus multilocularis orexin receptor type 2 0.0058 0.0153 0.0153
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0498 0.0498
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1538 1 1
Schistosoma mansoni myosin xvIII 0.0058 0.0153 0.0153
Trypanosoma brucei antigen, putative 0.0177 0.0946 0.2992
Loa Loa (eye worm) hypothetical protein 0.0069 0.0223 0.0223
Brugia malayi Probable myosin regulatory light chain 0.0048 0.0081 0.0081
Entamoeba histolytica cysteine protease, putative 0.0058 0.0149 0.0934
Onchocerca volvulus 0.0069 0.0223 0.1191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0099 0.0314
Giardia lamblia Programmed cell death protein-like protein 0.0048 0.0081 0.024
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0824 0.0824
Echinococcus granulosus cathepsin L 0.005 0.0099 0.0099
Trichomonas vaginalis calmodulin, putative 0.0079 0.0289 0.0915
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0058 0.0153 0.0153
Echinococcus multilocularis neuropeptide Y receptor 0.0058 0.0153 0.0153
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0038 0.0017 0.0017
Brugia malayi Dopamine receptor 0.0058 0.0153 0.0153
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0038 0.0017 0.0055
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.005 0.0099 0.0517
Echinococcus granulosus 7tm_1 domain containing protein 0.0058 0.0153 0.0153
Onchocerca volvulus Cathepsin F homolog 0.0069 0.0223 0.1191
Loa Loa (eye worm) neuropeptide F receptor 0.0058 0.0153 0.0153
Echinococcus multilocularis fk506 binding protein 0.0276 0.1599 0.1599
Echinococcus multilocularis cathepsin L 0.0058 0.0149 0.0149
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 0.0153 0.0153
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0082 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.012 0.038
Onchocerca volvulus 0.0061 0.0173 0.09
Giardia lamblia Cathepsin B precursor 0.051 0.3161 1
Schistosoma mansoni calpain-7 (C02 family) 0.018 0.0965 0.0965
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.038
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0276 0.1599 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0005 0.0005
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.1319 0.1319
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0038 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.0048 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Entamoeba histolytica cysteine protease, putative 0.0058 0.0149 0.0934
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.038
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0276 0.1599 1
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0038 0.0017 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0223 0.0705
Echinococcus granulosus biogenic amine 5HT receptor 0.0058 0.0153 0.0153
Brugia malayi Dopamine receptor protein 1 0.0058 0.0153 0.0153
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0005 0.0005
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.0804 0.0804
Brugia malayi Cathepsin L-like precursor 0.0061 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Plasmodium vivax hypothetical protein, conserved 0.011 0.0497 0.3031
Brugia malayi RasGEF domain containing protein 0.0048 0.0081 0.0081
Schistosoma mansoni calmodulin-related 0.0048 0.0081 0.0081
Brugia malayi calpain family protein 1 0.0471 0.2895 0.2895
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0058 0.0149 0.0149
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0053 0.012 0.012
Echinococcus multilocularis hypothetical protein 0.0177 0.0946 0.0946
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0099 0.0099
Mycobacterium leprae conserved hypothetical protein 0.011 0.0497 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0058 0.0149 0.0149
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.1319 0.1319
Schistosoma mansoni survival motor neuron protein 0.0048 0.0082 0.0082
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0058 0.0153 0.0153
Trypanosoma cruzi cysteine proteinase, putative 0.0058 0.0149 0.0149
Plasmodium falciparum serine repeat antigen 2 0.005 0.0099 0.0517
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0153 0.0153
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0497 0.0497
Brugia malayi chromobox protein homolog 3 0.0041 0.0036 0.0036
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0173 0.0173
Entamoeba histolytica papain family cysteine protease domain containing protein 0.005 0.0099 0.0621
Brugia malayi hypothetical protein 0.0058 0.0153 0.0153
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0056 0.0056
Leishmania major cathepsin L-like protease 0.0069 0.0223 0.0705
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0038 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.0297 0.1742 0.1742
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0038 0.0017 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0149 0.0473
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0017 0.0055
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.005 0.0099 0.0517
Schistosoma mansoni biogenic amine receptor 0.0058 0.0153 0.0153
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0048 0.0082 0.0082
Echinococcus multilocularis Calcium binding protein 0.0048 0.0081 0.0081
Echinococcus granulosus somatostatin receptor 0.0058 0.0153 0.0153
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.038
Plasmodium falciparum serine repeat antigen 1 0.005 0.0099 0.0517
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0276 0.1599 0.1599
Loa Loa (eye worm) hypothetical protein 0.011 0.0497 0.0497
Echinococcus granulosus FK506 binding protein 2 0.0038 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0223 0.0705
Loa Loa (eye worm) hypothetical protein 0.0293 0.1715 0.1715
Echinococcus granulosus neuropeptide Y receptor 0.0058 0.0153 0.0153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0223 0.0705
Echinococcus granulosus Myosin regulatory light chain 0.0048 0.0081 0.0081
Trichomonas vaginalis caltractin, putative 0.0048 0.0081 0.0257
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.038
Onchocerca volvulus 0.0058 0.0153 0.0787
Schistosoma mansoni memapsin-2 (A01 family) 0.0521 0.3231 0.3231
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.0804 0.0804
Schistosoma mansoni ets-related 0.0215 0.1194 0.1194
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0497 0.3031
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.038
Loa Loa (eye worm) beta-lactamase 0.011 0.0497 0.0497
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0153 0.0153
Onchocerca volvulus Cathepsin L homolog 0.0069 0.0223 0.1191
Echinococcus granulosus tachykinin peptides receptor 99D 0.0058 0.0153 0.0153
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0276 0.1599 0.1599
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0497 0.0497
Onchocerca volvulus 0.0058 0.0153 0.0787
Echinococcus multilocularis G protein coupled receptor 139 0.0058 0.0153 0.0153
Echinococcus multilocularis calpain family protein 1, d 0.0346 0.207 0.207
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0443 0.0443
Echinococcus multilocularis neuropeptide receptor 0.0058 0.0153 0.0153
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1538 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0069 0.0223 0.0223
Brugia malayi MAP kinase sur-1 0.0103 0.0449 0.0449
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0094 0.0094
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.038
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Trypanosoma brucei Calpain-like protein CALP1.3 0.0053 0.012 0.038
Echinococcus granulosus allatostatin A receptor 0.0058 0.0153 0.0153
Loa Loa (eye worm) calpain 0.0177 0.0946 0.0946
Loa Loa (eye worm) hypothetical protein 0.0417 0.2541 0.2541
Echinococcus granulosus peptide allatostatin:somatostatin 0.0058 0.0153 0.0153
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0058 0.0153 0.0153
Brugia malayi calpain 5 0.0124 0.0591 0.0591
Entamoeba histolytica cysteine protease, putative 0.0058 0.0149 0.0934
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0038 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.011 0.0497 0.0497
Echinococcus granulosus neuropeptides capa receptor 0.0058 0.0153 0.0153
Entamoeba histolytica cysteine protease, putative 0.005 0.0099 0.0621
Echinococcus granulosus neuropeptide receptor A26 0.0537 0.334 0.334
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0099 0.0099
Trypanosoma cruzi conserved protein 0.0053 0.012 0.012
Brugia malayi TAR-binding protein 0.0066 0.0201 0.0201
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0069 0.0223 0.0705
Plasmodium vivax serine-repeat antigen (SERA), putative 0.005 0.0099 0.0517
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0056 0.0178
Trypanosoma brucei calpain-like protein, putative 0.0177 0.0946 0.2992
Echinococcus granulosus tm gpcr rhodopsin 0.0058 0.0153 0.0153
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0058 0.0153 0.0153
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.0153 0.0153
Echinococcus granulosus neuropeptide receptor 0.0058 0.0153 0.0153
Schistosoma mansoni opsin-like receptor 0.0058 0.0153 0.0153
Echinococcus multilocularis sex peptide receptor 0.0058 0.0153 0.0153
Plasmodium falciparum serine repeat antigen 3 0.005 0.0099 0.0517
Plasmodium falciparum cysteine proteinase falcipain 1 0.0058 0.0149 0.0834
Brugia malayi hypothetical protein 0.0058 0.0153 0.0153
Trypanosoma cruzi centrin, putative 0.0079 0.0289 0.0289
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0276 0.1599 0.5049
Schistosoma mansoni hypothetical protein 0.0058 0.0153 0.0153
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0038 0.0017 0.5
Toxoplasma gondii calmodulin CAM2 0.0048 0.0081 0.0257
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Giardia lamblia Hypothetical protein 0.005 0.0099 0.0298
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0223 0.0705
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0497 0.0497
Onchocerca volvulus 0.0293 0.1715 0.9841
Trichomonas vaginalis calpain, putative 0.0053 0.012 0.038
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0497 0.1084
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0053 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Giardia lamblia Hypothetical protein 0.005 0.0099 0.0298
Loa Loa (eye worm) hypothetical protein 0.005 0.0099 0.0099
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0058 0.0153 0.0787
Plasmodium vivax unspecified product 0.005 0.0099 0.0517
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0038 0.0017 0.0055
Plasmodium falciparum serine repeat antigen 5 0.005 0.0099 0.0517
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0177 0.0946 0.0946
Echinococcus multilocularis g-protein coupled receptor 0.0058 0.0153 0.0153
Entamoeba histolytica hypothetical protein 0.011 0.0498 0.3114
Schistosoma mansoni amine GPCR 0.0058 0.0153 0.0153
Schistosoma mansoni calpain C (C02 family) 0.0177 0.0946 0.0946
Giardia lamblia Cathepsin L precursor 0.005 0.0099 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0153 0.0153
Trypanosoma brucei caltractin, putative 0.0079 0.0289 0.0915
Loa Loa (eye worm) hypothetical protein 0.005 0.0099 0.0099
Brugia malayi Dopamine receptor protein 2 0.0058 0.0153 0.0153
Brugia malayi Papain family cysteine protease containing protein 0.0058 0.0149 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0082 0.0082
Schistosoma mansoni myosin regulatory light chain 0.0048 0.0081 0.0081
Echinococcus granulosus calpain A 0.0177 0.0946 0.0946
Onchocerca volvulus 0.0069 0.0223 0.1191
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0223 0.0705
Giardia lamblia Encystation-specific protease 0.005 0.0099 0.0298
Giardia lamblia Cathepsin L precursor 0.005 0.0099 0.0298
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0056 0.0224
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0058 0.0153 0.0153
Trypanosoma brucei cysteine peptidase, putative 0.0053 0.012 0.038
Echinococcus granulosus orexin receptor type 2 0.0058 0.0153 0.0153
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0449 0.1421
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0053 0.012 0.038
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.005 0.0099 0.0517
Echinococcus granulosus cathepsin L cysteine protease 0.0058 0.0149 0.0149
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0058 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0223 0.0705
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Schistosoma mansoni cathepsin C 0.005 0.0099 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.0099 0.0314
Schistosoma mansoni hypothetical protein 0.0058 0.0153 0.0153
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0103 0.0449 0.0449
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.005 0.0099 0.0517
Echinococcus multilocularis somatostatin receptor 0.0058 0.0153 0.0153
Echinococcus multilocularis g protein coupled receptor 0.0058 0.0153 0.0153
Loa Loa (eye worm) calpain D 0.0053 0.012 0.012
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0201 0.0201
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0058 0.0153 0.0153
Echinococcus multilocularis programmed cell death protein 0.0079 0.0289 0.0289
Echinococcus multilocularis serotonin receptor 0.0058 0.0153 0.0153
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0053 0.012 0.038
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Onchocerca volvulus 0.0058 0.0153 0.0787
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0248 0.0248
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0498 0.0498
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0238 0.1347 0.1347
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0103 0.0449 0.1421
Entamoeba histolytica cysteine proteinase 2 0.0058 0.0149 0.0934
Loa Loa (eye worm) hypothetical protein 0.005 0.0099 0.0099
Leishmania major cathepsin L-like protease 0.0069 0.0223 0.0705
Leishmania major fk506-binding protein 1-like protein 0.0276 0.1599 0.5058
Toxoplasma gondii calmodulin, putative 0.0048 0.0081 0.0257
Echinococcus multilocularis neuropeptide Y receptor 0.0058 0.0153 0.0153
Leishmania major cathepsin L-like protease 0.0069 0.0223 0.0705
Echinococcus multilocularis neuropeptide receptor 0.0058 0.0153 0.0153
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0276 0.1599 0.1599
Echinococcus multilocularis neuropeptide FF receptor 2 0.0058 0.0153 0.0153
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0103 0.0449 0.0449
Trypanosoma brucei Calpain-like protein 1.1 0.0053 0.012 0.038
Plasmodium vivax vivapain-2 0.0069 0.0223 0.1299
Entamoeba histolytica cysteine protease, putative 0.0058 0.0149 0.0934
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.051 0.3161 0.3161
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0038 0.0017 0.0055
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0094 0.0094
Loa Loa (eye worm) cysteine protease 0.0069 0.0223 0.0223
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Entamoeba histolytica cysteine protease, putative 0.005 0.0099 0.0621
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Brugia malayi Cathepsin L-like precursor 0.0069 0.0223 0.0223
Schistosoma mansoni biogenic amine receptor 0.0058 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0223 0.0705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0149 0.0473
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0236 0.0236
Brugia malayi calpain family protein 1 0.0471 0.2895 0.2895
Giardia lamblia Cathepsin L precursor 0.005 0.0099 0.0298
Loa Loa (eye worm) hypothetical protein 0.0471 0.2895 0.2895
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.051 0.3161 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0223 0.0705
Loa Loa (eye worm) hypothetical protein 0.0048 0.0081 0.0081
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0497 0.1571
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Echinococcus multilocularis dro:myosuppressin receptor 0.0058 0.0153 0.0153
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0069 0.0223 0.1299
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0153 0.0153
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0081 0.0081
Brugia malayi cahepsin L-like non-peptiedase homolog 0.005 0.0099 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0099 0.0314
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0449 0.1421
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0223 0.0705
Schistosoma mansoni hypothetical protein 0.0058 0.0153 0.0153
Echinococcus multilocularis expressed conserved protein 0.0096 0.0402 0.0402
Plasmodium vivax vivapain-2 0.0069 0.0223 0.1299
Brugia malayi Papain family cysteine protease containing protein 0.0069 0.0223 0.0223
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0443 0.0443
Brugia malayi Cathepsin L-like precursor 0.0069 0.0223 0.0223
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0094 0.0094
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0497 0.1084
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0276 0.1599 0.1599
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0153 0.0153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0153 0.0153
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0017 0.0017
Onchocerca volvulus Cathepsin L homolog 0.005 0.0099 0.0474
Trypanosoma cruzi kinesin, putative 0.0124 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0005 0.0005
Brugia malayi cathepsin L precursor 0.005 0.0099 0.0099
Toxoplasma gondii preprocathepsin c precursor, putative 0.005 0.0099 0.0314
Schistosoma mansoni cathepsin S (C01 family) 0.005 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.005 0.0099 0.0099
Echinococcus multilocularis neuropeptides capa receptor 0.0058 0.0153 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0099 0.0314
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0153 0.0153
Loa Loa (eye worm) myosin Light Chain family member 0.0048 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Schistosoma mansoni opsin-like receptor 0.0058 0.0153 0.0153
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0038 0.0017 0.5
Echinococcus granulosus cathepsin L cysteine proteinase 0.0069 0.0223 0.0223
Brugia malayi beta-lactamase family protein 0.011 0.0497 0.0497
Brugia malayi CHE-14 protein 0.0044 0.0056 0.0056
Plasmodium falciparum serine repeat antigen 8 0.005 0.0099 0.0517
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0053 0.012 0.012
Schistosoma mansoni hypothetical protein 0.0521 0.323 0.323
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.005 0.0099 0.0517
Mycobacterium tuberculosis Conserved protein 0.011 0.0497 0.1084
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.051 0.3161 0.3161
Schistosoma mansoni hypothetical protein 0.0049 0.0094 0.0094
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0094 0.0094
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0058 0.0153 0.0153
Onchocerca volvulus 0.0058 0.0153 0.0787
Plasmodium vivax serine-repeat antigen (SERA), putative 0.005 0.0099 0.0517
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0005 0.0017
Loa Loa (eye worm) hypothetical protein 0.011 0.0497 0.0497
Schistosoma mansoni hypothetical protein 0.0107 0.0475 0.0475
Echinococcus multilocularis neuropeptide receptor A26 0.0537 0.334 0.334
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0276 0.1599 0.1599
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0502 0.3104 0.3104
Plasmodium vivax unspecified product 0.0058 0.0149 0.0834
Schistosoma mansoni Mername-AA248 (C02 family) 0.0177 0.0946 0.0946
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0056 0.0177
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0038 0.0017 0.0017
Entamoeba histolytica cysteine proteinase, putative 0.0058 0.0149 0.0934
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.012
Echinococcus multilocularis serotonin receptor 0.0058 0.0153 0.0153
Brugia malayi G protein-coupled receptor F59B2.13 0.0058 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0223 0.0705
Onchocerca volvulus 0.0058 0.0153 0.0787
Loa Loa (eye worm) hypothetical protein 0.0234 0.1319 0.1319
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0058 0.0153 0.0153
Schistosoma mansoni neuropeptide receptor 0.0058 0.0153 0.0153
Echinococcus granulosus sex peptide receptor 0.0058 0.0153 0.0153
Brugia malayi RNA binding protein 0.0066 0.0201 0.0201
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0069 0.0223 0.0223
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0497 0.0497
Trypanosoma brucei calpain, putative 0.0053 0.012 0.038
Mycobacterium ulcerans lipase LipD 0.011 0.0497 0.3031
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0069 0.0223 0.0705
Brugia malayi larval opioid receptor 0.0058 0.0153 0.0153
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0824 0.0824
Brugia malayi hypothetical protein 0.0058 0.0153 0.0153
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0058 0.0153 0.0153
Schistosoma mansoni hypothetical protein 0.0049 0.0094 0.0094
Entamoeba histolytica calmodulin, putative 0.0048 0.0081 0.0508
Onchocerca volvulus 0.011 0.0497 0.2779
Echinococcus multilocularis calpain 5 0.0177 0.0946 0.0946
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0094 0.0094
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 0.0153 0.0153
Schistosoma mansoni adenoreceptor 0.0058 0.0153 0.0153
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0223 0.0705
Leishmania major cathepsin L-like protease 0.0069 0.0223 0.0705
Entamoeba histolytica cysteine protease, putative 0.0058 0.0149 0.0934
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0017 0.0055
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0058 0.0153 0.0153
Trypanosoma cruzi cysteine proteinase, putative 0.0058 0.0149 0.0149
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0099 0.0314
Entamoeba histolytica hypothetical protein 0.011 0.0498 0.3114
Loa Loa (eye worm) myosin regulatory light chain 1 0.0048 0.0081 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0449 0.0449
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0223 0.0223
Loa Loa (eye worm) calpain family protein 1 0.0471 0.2895 0.2895
Entamoeba histolytica cysteine protease, putative 0.005 0.0099 0.0621
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0061 0.0173 0.0173
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.012
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0038 0.0017 0.0055
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0471 0.2895 0.2895
Brugia malayi beta-lactamase family protein 0.011 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0061 0.0173 0.0173
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0017 0.0055
Schistosoma mansoni hypothetical protein 0.0042 0.0046 0.0046
Schistosoma mansoni immunophilin 0.0276 0.1599 0.1599
Brugia malayi neuropeptide F receptor 0.0058 0.0153 0.0153
Schistosoma mansoni neuropeptide F-like receptor 0.0058 0.0153 0.0153
Echinococcus granulosus programmed cell death protein 6 0.0048 0.0081 0.0081
Giardia lamblia Cathepsin L-like protease 0.005 0.0099 0.0298
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0058 0.0153 0.0153
Trichomonas vaginalis calmodulin, putative 0.0048 0.0081 0.0257
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0058 0.0153 0.0153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0153 0.0153
Giardia lamblia Kinase, CMGC MAPK 0.0103 0.0449 0.1406
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0276 0.1599 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0069 0.0223 0.1299
Mycobacterium ulcerans hypothetical protein 0.011 0.0497 0.3031
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0038 0.0017 0.0038
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0053 0.012 0.038
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.1538 1 1
Trichomonas vaginalis fk506-binding protein, putative 0.0038 0.0017 0.0055
Echinococcus granulosus chromobox protein 1 0.0073 0.0248 0.0248
Entamoeba histolytica grainin 2 0.0079 0.0289 0.181
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0502 0.3104 0.3104
Echinococcus granulosus mitogen activated protein kinase 3 0.0103 0.0449 0.0449
Echinococcus multilocularis g protein coupled receptor 0.0058 0.0153 0.0153
Echinococcus granulosus fmrfamide receptor 0.0058 0.0153 0.0153
Toxoplasma gondii centrin family protein 0.0048 0.0081 0.0257
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0094 0.0094
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0038 0.0017 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0153 0.0153
Schistosoma mansoni calpain-2 (C02 family) 0.0053 0.012 0.012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0153 0.0153
Brugia malayi cathepsin Z-like cysteine proteinase 0.005 0.0099 0.0099
Giardia lamblia Cysteine protease 0.005 0.0099 0.0298
Schistosoma mansoni neuropeptide receptor 0.0058 0.0153 0.0153
Echinococcus granulosus neuropeptide receptor 0.0058 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0103 0.0449 0.1421
Loa Loa (eye worm) hypothetical protein 0.0048 0.0081 0.0081
Entamoeba histolytica cysteine protease, putative 0.0058 0.0149 0.0934
Loa Loa (eye worm) RNA binding protein 0.0066 0.0201 0.0201
Trichomonas vaginalis calcium binding protein, putative 0.0048 0.0081 0.0257
Echinococcus multilocularis protein dispatched 1 0.005 0.0097 0.0097
Brugia malayi RE15519p 0.0058 0.0153 0.0153
Echinococcus multilocularis cathepsin L 0.005 0.0099 0.0099
Plasmodium vivax vivapain-3 0.0058 0.0149 0.0834
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0177 0.0946 0.2992
Schistosoma mansoni hypothetical protein 0.0042 0.0046 0.0046
Brugia malayi Cathepsin L-like cysteine proteinase 0.0061 0.0173 0.0173
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0177 0.0946 0.0946
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0223 0.0705
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.038
Plasmodium falciparum cysteine proteinase falcipain 3 0.0069 0.0223 0.1299
Onchocerca volvulus 0.0058 0.0153 0.0787
Loa Loa (eye worm) hypothetical protein 0.006 0.0167 0.0167
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0017 0.0109
Toxoplasma gondii cathepsin CPL 0.0069 0.0223 0.0705
Echinococcus multilocularis calpain 0.0177 0.0946 0.0946
Brugia malayi hypothetical protein 0.0058 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0053 0.012 0.038
Onchocerca volvulus 0.0058 0.0153 0.0787
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.0734 0.0734
Entamoeba histolytica hypothetical protein 0.011 0.0498 0.3114
Echinococcus multilocularis GPCR, family 2 0.0049 0.0094 0.0094
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0276 0.1599 0.5058
Entamoeba histolytica cysteine protease, putative 0.0058 0.0149 0.0934
Schistosoma mansoni cathepsin B (C01 family) 0.005 0.0099 0.0099
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0201 0.0201
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0069 0.0223 0.0223
Onchocerca volvulus 0.005 0.0099 0.0474
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0038 0.0017 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Brugia malayi hypothetical protein 0.0058 0.0153 0.0153
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0099 0.0099
Echinococcus granulosus alpha 1A adrenergic receptor 0.0058 0.0153 0.0153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0223 0.0705
Brugia malayi Cathepsin L-like precursor 0.0061 0.0173 0.0173
Schistosoma mansoni gabp alpha 0.0071 0.0236 0.0236
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0005 0.0017
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0103 0.0449 0.1421
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.0048 0.0081 0.0369
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0053 0.012 0.038
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.005 0.0099 0.0314
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.0223 0.0705
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Schistosoma mansoni amine GPCR 0.0058 0.0153 0.0153
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0005 0.0017
Trypanosoma brucei hypothetical protein 0.0053 0.012 0.038
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0443 0.2771
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.0099 0.0099
Plasmodium vivax vivapain-1 0.0058 0.0149 0.0834
Brugia malayi Ets-domain containing protein 0.0071 0.0236 0.0236
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1538 1 1
Brugia malayi calpain D 0.0053 0.012 0.012
Echinococcus granulosus cathepsin L 0.0058 0.0149 0.0149
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0276 0.1599 0.5058
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0153 0.0153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0223 0.0705
Brugia malayi G-protein coupled receptor 0.0058 0.0153 0.0153
Brugia malayi ORL1-like opioid receptor 0.0058 0.0153 0.0153
Entamoeba histolytica cysteine protease, putative 0.0058 0.0149 0.0934
Echinococcus granulosus cathepsin b 0.1538 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0058 0.0153 0.0153
Plasmodium vivax myosin A tail domain interacting protein MTIP, putative 0.0048 0.0081 0.0403
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0223 0.0705
Echinococcus multilocularis chromobox protein 1 0.0073 0.0248 0.0248
Onchocerca volvulus 0.0069 0.0223 0.1191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0223 0.0705
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0058 0.0153 0.0153
Onchocerca volvulus 0.011 0.0497 0.2779
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0082 0.0082
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.038
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.038
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0177 0.0946 0.2992
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0153 0.0153
Echinococcus multilocularis geminin 0.0521 0.323 0.323
Echinococcus granulosus expressed conserved protein 0.0096 0.0402 0.0402
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0058 0.0149 0.0149
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0038 0.0017 0.0017
Brugia malayi GnHR receptor homolog 0.0058 0.0153 0.0153
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0177 0.0946 0.0946
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0099 0.0099
Schistosoma mansoni amine GPCR 0.0058 0.0153 0.0153
Echinococcus multilocularis allatostatin A receptor 0.0058 0.0153 0.0153
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0058 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.005 0.0099 0.0099
Brugia malayi Cathepsin L-like precursor 0.0069 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0049 0.0094 0.0094
Toxoplasma gondii ABC1 family protein 0.011 0.0497 0.1571
Trypanosoma cruzi centrin, putative 0.0079 0.0289 0.0289
Plasmodium falciparum serine repeat antigen 9 0.005 0.0099 0.0517
Onchocerca volvulus 0.0092 0.0377 0.2087
Schistosoma mansoni alpha-1 adrenergic receptor 0.0058 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0173 0.0546
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.0454 0.0454
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0053 0.012 0.012
Brugia malayi cathepsin L-like precursor 0.0061 0.0173 0.0173
Schistosoma mansoni biogenic amine (5HT) receptor 0.0058 0.0153 0.0153
Schistosoma mansoni neuropeptide receptor 0.0058 0.0153 0.0153
Onchocerca volvulus Cathepsin L homolog 0.0069 0.0223 0.1191
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0038 0.0017 0.0055
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0223 0.0223
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0058 0.0153 0.0153
Loa Loa (eye worm) fli-1 protein 0.0215 0.1194 0.1194
Echinococcus granulosus g protein coupled receptor 0.0058 0.0153 0.0153
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0276 0.1599 0.5049
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0056 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0017 0.0055
Toxoplasma gondii cathepsin CPC1 0.005 0.0099 0.0314
Echinococcus granulosus cathepsin l1 0.0069 0.0223 0.0223
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0177 0.0946 0.0946
Plasmodium vivax calpain, putative 0.0177 0.0946 0.5871
Trichomonas vaginalis calcium binding protein, putative 0.0079 0.0289 0.0915
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0346 0.207 0.207
Echinococcus multilocularis neuropeptides capa receptor 0.0058 0.0153 0.0153
Giardia lamblia Cathepsin L precursor 0.005 0.0099 0.0298
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0053 0.012 0.012
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.012
Leishmania major cysteine peptidase A (CPA) 0.0069 0.0223 0.0705
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0177 0.0946 0.0946
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0005 0.0017
Brugia malayi fibroinase precursor 0.005 0.0099 0.0099
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0497 0.1084
Schistosoma mansoni opsin-like receptor 0.0058 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Echinococcus granulosus calpain 7 C02 family 0.0177 0.0946 0.0946
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0058 0.0153 0.0153
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0497 0.1571
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0153 0.0153
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0248 0.0783
Brugia malayi calpain 7 0.0177 0.0946 0.0946
Plasmodium falciparum calpain 0.0053 0.012 0.0649
Trypanosoma brucei centrin-3 0.0079 0.0289 0.0915
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0036 0.0113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0223 0.0705
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0276 0.1599 0.1599
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0036 0.0113
Giardia lamblia Hypothetical protein 0.0038 0.0017 0.0038
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0058 0.0153 0.0153
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0082 0.0082
Loa Loa (eye worm) ctsf protein 0.0069 0.0223 0.0223
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0449 0.0449
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0276 0.1599 1
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0177 0.0946 0.0946
Trichomonas vaginalis kakapo, putative 0.0048 0.0081 0.0257
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Echinococcus granulosus neuropeptide s receptor 0.0537 0.334 0.334
Schistosoma mansoni histamine h1 receptor 0.0058 0.0153 0.0153
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0058 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0053 0.012 0.038
Mycobacterium ulcerans beta-lactamase 0.011 0.0497 0.3031
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0005 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0153 0.0153
Trichomonas vaginalis immunophilin, putative 0.0276 0.1599 0.5058
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0497 0.1084
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0153 0.0153
Echinococcus granulosus g protein coupled receptor 0.0058 0.0153 0.0153
Mycobacterium tuberculosis Conserved protein 0.011 0.0497 0.1084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0223 0.0705
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0824 0.0824
Trichomonas vaginalis hypothetical protein 0.0053 0.012 0.038
Loa Loa (eye worm) cathepsin B 0.051 0.3161 0.3161
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0038 0.0017 0.0038
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.038
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.0048 0.0081 0.0257
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.038
Giardia lamblia Cathepsin B precursor 0.051 0.3161 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0058 0.0153 0.0153
Plasmodium falciparum serine repeat antigen 6 0.005 0.0099 0.0517
Echinococcus multilocularis programmed cell death protein 0.0079 0.0289 0.0289
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.012 0.038
Schistosoma mansoni neuropeptide F-like receptor 0.0058 0.0153 0.0153
Onchocerca volvulus 0.0058 0.0153 0.0787
Schistosoma mansoni biogenic amine (5HT) receptor 0.0058 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0238 0.1347 0.1347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0099 0.0314
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0177 0.0946 0.2992
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0236 0.0236
Echinococcus granulosus Calcium binding protein 0.0048 0.0081 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.0223 0.0705
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0017 0.0055
Leishmania major cathepsin L-like protease 0.0069 0.0223 0.0705
Loa Loa (eye worm) hypothetical protein 0.0061 0.0173 0.0173
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0201 0.0201
Onchocerca volvulus 0.0069 0.0223 0.1191
Schistosoma mansoni hypothetical protein 0.0038 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.0153
Giardia lamblia Cathepsin L precursor 0.005 0.0099 0.0298
Schistosoma mansoni hypothetical protein 0.0521 0.323 0.323
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0153 0.0153
Brugia malayi Heterochromatin protein 1 0.0073 0.0248 0.0248
Leishmania major kinesin, putative 0.0124 0.0591 0.1869
Echinococcus multilocularis cysteine protease 0.0069 0.0223 0.0223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0223 0.0705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0099 0.0314

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 34 nM Inhibition of human BACE1 by ECL based assay ChEMBL. 17257835
IC50 (binding) = 34 nM Inhibition of human BACE1 by ECL based assay ChEMBL. 17257835
IC50 (binding) = 279 nM Inhibition of human BACE1 assessed as sAPPNF accumulation ChEMBL. 17257835
IC50 (binding) = 279 nM Inhibition of human BACE1 assessed as sAPPNF accumulation ChEMBL. 17257835

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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