Detailed information for compound 866885

Basic information

Technical information
  • TDR Targets ID: 866885
  • Name: N-(2-diethylaminoethyl)-2-[8-methyl-7-(pyrrol idine-1-carbonyl)-4,5-dihydrofuro[2,3-g]indaz ol-2-yl]acetamide
  • MW: 427.54 | Formula: C23H33N5O3
  • H donors: 1 H acceptors: 3 LogP: 2.15 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCNC(=O)Cn1cc2c(n1)c1c(CC2)oc(c1C)C(=O)N1CCCC1)CC
  • InChi: 1S/C23H33N5O3/c1-4-26(5-2)13-10-24-19(29)15-28-14-17-8-9-18-20(21(17)25-28)16(3)22(31-18)23(30)27-11-6-7-12-27/h14H,4-13,15H2,1-3H3,(H,24,29)
  • InChiKey: HJCBMJCNAGDOKS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-diethylaminoethyl)-2-[8-methyl-7-(oxo-1-pyrrolidinylmethyl)-4,5-dihydrofuro[2,3-g]indazol-2-yl]acetamide
  • N-(2-diethylaminoethyl)-2-(8-methyl-7-pyrrolidin-1-ylcarbonyl-4,5-dihydrofuro[2,3-g]indazol-2-yl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0354 0.0796
Brugia malayi cathepsin L-like precursor 0.0552 0.2559 0.2559
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0194 0.0803 0.0803
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Brugia malayi cathepsin Z-like cysteine proteinase 0.0194 0.0803 0.0803
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Plasmodium vivax unspecified product 0.0438 0.2001 0.5326
Loa Loa (eye worm) hypothetical protein 0.0272 0.1186 0.1186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Echinococcus multilocularis pyruvate kinase 0.0036 0.0026 0.0024
Giardia lamblia Cathepsin L precursor 0.0194 0.0803 0.2146
Trypanosoma brucei calpain, putative 0.0031 0.0002 0.0004
Toxoplasma gondii cathepsin CPL 0.0796 0.3757 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0073 0.0209 0.055
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0226 0.0225
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.0048 0.0046
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.0048
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0112 0.0401 0.1068
Loa Loa (eye worm) hypothetical protein 0.004 0.0045 0.0045
Trypanosoma cruzi cysteine proteinase, putative 0.0438 0.2001 0.2001
Loa Loa (eye worm) ctsf protein 0.0796 0.3757 0.3757
Onchocerca volvulus Peroxidasin homolog 0.0106 0.0369 0.0979
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0796 0.3757 0.3756
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0803 0.2134
Loa Loa (eye worm) hypothetical protein 0.0036 0.0026 0.0026
Giardia lamblia Cathepsin B precursor 0.0773 0.3648 1
Plasmodium vivax vivapain-3 0.0438 0.2001 0.5326
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0194 0.0803 0.2134
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0194 0.0803 0.0803
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.0803 0.2134
Giardia lamblia Cathepsin B precursor 0.0194 0.0803 0.2146
Entamoeba histolytica cysteine proteinase, putative 0.0438 0.2001 0.5323
Plasmodium falciparum serine repeat antigen 7 0.0194 0.0803 0.2138
Loa Loa (eye worm) hypothetical protein 0.0169 0.0682 0.0682
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0002 0.0005
Onchocerca volvulus 0.0796 0.3757 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0226 0.0225
Plasmodium falciparum calpain 0.0031 0.0002 0.0005
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0194 0.0803 0.2138
Schistosoma mansoni transient receptor potential channel 4 0.0117 0.0426 0.0425
Loa Loa (eye worm) hypothetical protein 0.0194 0.0803 0.0803
Echinococcus granulosus calpain 5 0.0103 0.0354 0.0352
Entamoeba histolytica protein kinase, putative 0.0072 0.0203 0.0535
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0401 0.1063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0194 0.0803 0.2138
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0194 0.0803 0.2134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0194 0.0803 0.2134
Giardia lamblia Cathepsin B precursor 0.0194 0.0803 0.2146
Onchocerca volvulus Cathepsin L homolog 0.0194 0.0803 0.2136
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2067 1 1
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0369 0.0369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Schistosoma mansoni cathepsin s 0.0244 0.1048 0.1047
Leishmania major hypothetical protein, unknown function 0.0031 0.0002 0.0004
Plasmodium falciparum serine repeat antigen 3 0.0194 0.0803 0.2138
Loa Loa (eye worm) cysteine protease 0.0796 0.3757 0.3757
Loa Loa (eye worm) calpain family protein 1 0.02 0.0833 0.0833
Leishmania major cathepsin L-like protease 0.0937 0.4449 1
Leishmania major cysteine peptidase A (CPA) 0.0796 0.3757 0.8443
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0803 0.0802
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0034 0.0033
Echinococcus granulosus calpain A 0.0291 0.1281 0.1279
Onchocerca volvulus Dual oxidase homolog 0.0106 0.0369 0.0979
Trypanosoma cruzi cysteine peptidase, putative 0.0937 0.4449 0.4449
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0002 0.0001
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0026 0.0066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Leishmania major pyruvate kinase 0.0036 0.0026 0.0058
Onchocerca volvulus 0.0106 0.0369 0.0979
Mycobacterium ulcerans proteasome PrcB 0.0073 0.0209 1
Entamoeba histolytica cysteine proteinase, putative 0.0438 0.2001 0.5323
Brugia malayi Cathepsin L-like precursor 0.0796 0.3757 0.3757
Leishmania major metacaspase, putative 0.0112 0.0401 0.0902
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0112 0.0401 0.04
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0194 0.0803 0.2138
Brugia malayi MH2 domain containing protein 0.024 0.1028 0.1028
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Brugia malayi calpain 7 0.0103 0.0354 0.0354
Brugia malayi cathepsin Z-like cysteine proteinase 0.0194 0.0803 0.0803
Plasmodium falciparum cysteine proteinase falcipain 1 0.0438 0.2001 0.5326
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0161 0.0362
Onchocerca volvulus 0.0796 0.3757 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0161 0.7387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0803 0.2134
Echinococcus multilocularis peroxidasin 0.0106 0.0369 0.0367
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0194 0.0803 0.0802
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0254 0.1098 0.1096
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0803 0.0802
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Brugia malayi Blistered cuticle protein 3 0.0106 0.0369 0.0369
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0438 0.2001 0.2001
Trypanosoma cruzi metacaspase 5, putative 0.0112 0.0401 0.0401
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0099 0.0098
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0796
Echinococcus multilocularis neuropeptide s receptor 0.0486 0.2237 0.2236
Loa Loa (eye worm) hypothetical protein 0.0552 0.2559 0.2559
Leishmania major kinesin, putative 0.0072 0.0203 0.0456
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Schistosoma mansoni dopamine-beta-monooxygenase 0.0246 0.1058 0.1058
Loa Loa (eye worm) hypothetical protein 0.0552 0.2559 0.2559
Schistosoma mansoni hypothetical protein 0.0031 0.0002 0.0001
Brugia malayi calpain family protein 1 0.0272 0.1186 0.1186
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0312 0.0312
Schistosoma mansoni pyruvate kinase 0.0036 0.0026 0.0025
Schistosoma mansoni caspase-7 (C14 family) 0.0152 0.0598 0.0597
Onchocerca volvulus 0.0031 0.0002 0.0002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2067 1 1
Echinococcus granulosus cysteine protease 0.0438 0.2001 0.1999
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.0803 0.0803
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0312 0.031
Loa Loa (eye worm) hypothetical protein 0.0796 0.3757 0.3757
Onchocerca volvulus 0.0796 0.3757 1
Plasmodium vivax metacaspase 1, putative 0.0112 0.0401 0.1068
Schistosoma mansoni cathepsin C 0.0194 0.0803 0.0802
Plasmodium falciparum serine repeat antigen 5 0.0194 0.0803 0.2138
Echinococcus multilocularis transient receptor potential gamma protein 0.0117 0.0426 0.0424
Echinococcus multilocularis microtubule associated protein 2 0.0739 0.348 0.3479
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0161 0.7387
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.0231 0.0229
Brugia malayi Pre-SET motif family protein 0.0215 0.0905 0.0905
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0026 0.0069
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0194 0.0803 0.2138
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0401 0.1063
Loa Loa (eye worm) fibroinase 0.0796 0.3757 0.3757
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0401 0.1063
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0194 0.0803 0.2138
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0002 0.0002
Leishmania major hypothetical protein, conserved 0.0031 0.0002 0.0004
Loa Loa (eye worm) calpain family protein 1 0.0272 0.1186 0.1186
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.0231 0.0229
Plasmodium vivax unspecified product 0.0244 0.1048 0.2789
Echinococcus granulosus neuropeptide s receptor 0.0486 0.2237 0.2236
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Echinococcus granulosus survival motor neuron protein 1 0.025 0.1077 0.1076
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0112 0.0401 0.1068
Loa Loa (eye worm) hypothetical protein 0.025 0.1077 0.1077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Plasmodium falciparum serine repeat antigen 4 0.0194 0.0803 0.2138
Schistosoma mansoni cathepsin F (C01 family) 0.0796 0.3757 0.3756
Echinococcus granulosus cathepsin l1 0.0796 0.3757 0.3756
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0803 0.0802
Plasmodium falciparum pyruvate kinase 0.0036 0.0026 0.0069
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0002
Trypanosoma brucei Calpain-like protein 1.2 0.0031 0.0002 0.0004
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.1077 0.1076
Echinococcus granulosus cathepsin L cysteine protease 0.0438 0.2001 0.1999
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0034 0.0033
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0226 0.0224
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0463 0.2125 0.2123
Schistosoma mansoni transient receptor potential channel 0.0078 0.0231 0.023
Entamoeba histolytica cysteine protease, putative 0.0194 0.0803 0.2134
Schistosoma mansoni cathepsin S (C01 family) 0.0194 0.0803 0.0802
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0354 0.0796
Echinococcus granulosus microtubule associated protein 2 0.0739 0.348 0.3479
Plasmodium falciparum metacaspase-like protein 0.0112 0.0401 0.1068
Echinococcus granulosus TRP transient receptor potential channel 0.0044 0.0065 0.0063
Schistosoma mansoni peroxidasin 0.0106 0.0369 0.0368
Loa Loa (eye worm) hypothetical protein 0.0112 0.0401 0.0401
Schistosoma mansoni calpain C (C02 family) 0.0103 0.0354 0.0353
Echinococcus granulosus proteasome prosome macropain 0.0073 0.0209 0.0207
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0194 0.0803 0.2138
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0073 0.0209 0.0209
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0796
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0773 0.3648 0.8198
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Loa Loa (eye worm) hypothetical protein 0.02 0.0833 0.0833
Schistosoma mansoni microtubule-associated protein tau 0.0739 0.348 0.3479
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0803 0.2134
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0035 0.0035
Schistosoma mansoni caspase-3 (C14 family) 0.0254 0.1098 0.1097
Echinococcus multilocularis caspase 2 0.0152 0.0598 0.0597
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0194 0.0803 0.0802
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.0803 0.0803
Echinococcus granulosus cathepsin L 0.0194 0.0803 0.0802
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Echinococcus granulosus cathepsin l cysteine peptidase 0.0796 0.3757 0.3756
Giardia lamblia Hypothetical protein 0.0194 0.0803 0.2146
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0044 0.0065 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Loa Loa (eye worm) hypothetical protein 0.017 0.0685 0.0685
Trypanosoma brucei metacaspase 5, putative 0.0112 0.0401 0.0902
Entamoeba histolytica cysteine proteinase 1, putative 0.0438 0.2001 0.5323
Brugia malayi cathepsin L precursor 0.0194 0.0803 0.0803
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0073 0.0209 0.055
Echinococcus granulosus calpain A 0.0103 0.0354 0.0352
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Brugia malayi Peroxidasin 0.0106 0.0369 0.0369
Echinococcus granulosus caspase 8 0.0112 0.0401 0.0399
Schistosoma mansoni cathepsin B (C01 family) 0.0194 0.0803 0.0802
Onchocerca volvulus Peroxidase homolog 0.0106 0.0369 0.0979
Loa Loa (eye worm) hypothetical protein 0.0194 0.0803 0.0803
Brugia malayi Cathepsin L-like precursor 0.0796 0.3757 0.3757
Trypanosoma cruzi cysteine peptidase, putative 0.0438 0.2001 0.2001
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0401 0.1063
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0079 0.0236 0.0235
Entamoeba histolytica calpain large subunit domain III containing protein 0.0072 0.0203 0.0535
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0125 0.0464 0.0464
Echinococcus multilocularis caspase 3 0.0142 0.0547 0.0545
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0026 0.0026
Entamoeba histolytica cysteine proteinase, putative 0.0552 0.2559 0.6811
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0194 0.0803 0.2138
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0773 0.3648 0.3647
Trypanosoma cruzi cysteine proteinase, putative 0.0438 0.2001 0.2001
Onchocerca volvulus Cathepsin L homolog 0.0796 0.3757 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Brugia malayi Proteasome A-type and B-type family protein 0.0073 0.0209 0.0209
Echinococcus multilocularis cysteine protease 0.0796 0.3757 0.3756
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0796
Loa Loa (eye worm) matrixin family protein 0.0048 0.0086 0.0086
Echinococcus granulosus calpain 0.0103 0.0354 0.0352
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Entamoeba histolytica cysteine proteinase, putative 0.0438 0.2001 0.5323
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0161 0.7387
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0291 0.1278 0.1277
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0312 0.0311
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0796 0.3757 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Trypanosoma cruzi cysteine peptidase, putative 0.0244 0.1048 0.1048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2067 1 1
Brugia malayi Hemopexin family protein 0.0031 0.0001 0.0001
Toxoplasma gondii cathepsin CPC2 0.0194 0.0803 0.2138
Leishmania major cathepsin L-like protease 0.0796 0.3757 0.8443
Onchocerca volvulus 0.0244 0.1051 0.2795
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0026 0.0026
Onchocerca volvulus Matrilysin homolog 0.0048 0.0086 0.0226
Brugia malayi Matrixin family protein 0.0052 0.0107 0.0107
Giardia lamblia Cathepsin L precursor 0.0194 0.0803 0.2146
Brugia malayi Cathepsin L-like precursor 0.0552 0.2559 0.2559
Loa Loa (eye worm) hypothetical protein 0.0074 0.0212 0.0212
Brugia malayi RNA binding protein 0.0076 0.0226 0.0226
Entamoeba histolytica cysteine proteinase, putative 0.0796 0.3757 1
Trypanosoma brucei Calpain-like protein 2 0.0031 0.0002 0.0004
Giardia lamblia Cathepsin L precursor 0.0194 0.0803 0.2146
Onchocerca volvulus 0.0106 0.0369 0.0979
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0803 0.2134
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Onchocerca volvulus Peroxidase homolog 0.0106 0.0369 0.0979
Trypanosoma brucei cysteine peptidase, putative 0.0031 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0194 0.0803 0.2134
Trypanosoma cruzi cysteine peptidase, putative 0.0796 0.3757 0.3757
Schistosoma mansoni peroxidasin 0.0106 0.0369 0.0368
Toxoplasma gondii hypothetical protein 0.0031 0.0002 0.0005
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0194 0.0803 0.2138
Leishmania major cathepsin L-like protease 0.0796 0.3757 0.8443
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0312 0.031
Loa Loa (eye worm) hypothetical protein 0.0044 0.0065 0.0065
Plasmodium falciparum serine repeat antigen 8 0.0194 0.0803 0.2138
Echinococcus granulosus single minded 2 0.0037 0.0035 0.0033
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2067 1 1
Onchocerca volvulus 0.0796 0.3757 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0354
Plasmodium vivax serine-repeat antigen (SERA) 0.0194 0.0803 0.2138
Loa Loa (eye worm) matrixin family protein 0.0052 0.0107 0.0107
Plasmodium vivax vivapain-2 0.0796 0.3757 1
Echinococcus granulosus transient receptor potential gamma protein 0.0117 0.0426 0.0424
Giardia lamblia Cysteine protease 0.0194 0.0803 0.2146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0354 0.0796
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Entamoeba histolytica cysteine protease, putative 0.0194 0.0803 0.2134
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0161 0.0159
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0194 0.0803 0.2134
Echinococcus multilocularis pyruvate kinase 0.0036 0.0026 0.0024
Leishmania major cathepsin L-like protease 0.0937 0.4449 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.0803 0.0803
Echinococcus granulosus tar DNA binding protein 0.0076 0.0226 0.0224
Plasmodium vivax vivapain-2 0.0796 0.3757 1
Leishmania major cathepsin L-like protease 0.0937 0.4449 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0194 0.0803 0.2134
Entamoeba histolytica cysteine proteinase, putative 0.0438 0.2001 0.5323
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0101 0.0101
Schistosoma mansoni single-minded 0.0051 0.0099 0.0098
Trypanosoma cruzi conserved protein 0.0031 0.0002 0.0002
Trypanosoma cruzi cruzipain precursor, putative 0.0244 0.1048 0.1048
Schistosoma mansoni calpain-2 (C02 family) 0.0031 0.0002 0.0001
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0194 0.0803 0.2138
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Giardia lamblia Cathepsin L precursor 0.0194 0.0803 0.2146
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0035 0.047
Trypanosoma cruzi kinesin, putative 0.0072 0.0203 0.0203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0803 0.2134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Entamoeba histolytica hypothetical protein 0.0194 0.0803 0.2134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0803 0.2134
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0803 0.2134
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0194 0.0803 0.2134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Brugia malayi TAR-binding protein 0.0076 0.0226 0.0226
Echinococcus multilocularis geminin 0.0181 0.0742 0.074
Entamoeba histolytica hypothetical protein 0.0037 0.0034 0.0086
Brugia malayi hypothetical protein 0.0106 0.0369 0.0369
Onchocerca volvulus Cathepsin F homolog 0.0796 0.3757 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0194 0.0803 0.2146
Entamoeba histolytica cysteine proteinase 2 0.0438 0.2001 0.5323
Giardia lamblia Cathepsin B precursor 0.0194 0.0803 0.2146
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0035 0.0033
Schistosoma mansoni pyruvate kinase 0.0036 0.0026 0.0025
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0244 0.1048 0.1048
Trypanosoma cruzi kinesin, putative 0.0072 0.0203 0.0203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0552 0.2559 0.6811
Echinococcus multilocularis hypothetical protein 0.0103 0.0354 0.0352
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0031 0.0002 0.0005
Loa Loa (eye worm) RNA binding protein 0.0076 0.0226 0.0226
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0401 0.1068
Trypanosoma brucei calpain, putative 0.0031 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0438 0.2001 0.5323
Echinococcus granulosus peroxidasin 0.0106 0.0369 0.0367
Loa Loa (eye worm) hypothetical protein 0.0194 0.0803 0.0803
Trypanosoma brucei Calpain-like protein 1.1 0.0031 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0117 0.0426 0.0426
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0051 0.0101 0.01
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0226 0.0225
Echinococcus multilocularis calpain family protein 1, d 0.02 0.0833 0.0832
Brugia malayi hypothetical protein 0.0037 0.0034 0.0034
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0073 0.0209 0.0209
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0803 0.0802
Echinococcus multilocularis cathepsin L cysteine protease 0.0796 0.3757 0.3756
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0026 0.0026
Trichomonas vaginalis set domain proteins, putative 0.0244 0.1051 0.2793
Brugia malayi cathepsin F-like cysteine proteinase 0.0244 0.1048 0.1048
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0354 0.0354
Loa Loa (eye worm) hypoxia-induced factor 1 0.0157 0.062 0.062
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0693 0.3252 0.3252
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0073 0.0209 0.0469
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0073 0.0209 0.0209
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0194 0.0803 0.2138
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0369 0.0369
Brugia malayi calpain D 0.0031 0.0002 0.0002
Plasmodium vivax serine-repeat antigen (SERA) 0.0194 0.0803 0.2138
Trypanosoma brucei hypothetical protein 0.0031 0.0002 0.0004
Brugia malayi Pre-SET motif family protein 0.0031 0.0002 0.0002
Brugia malayi Cathepsin L-like precursor 0.0796 0.3757 0.3757
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0073 0.0209 1
Echinococcus multilocularis cysteine protease 0.0796 0.3757 0.3756
Loa Loa (eye worm) calpain 5 0.0072 0.0203 0.0203
Plasmodium falciparum serine repeat antigen 1 0.0194 0.0803 0.2138
Onchocerca volvulus 0.0051 0.0101 0.0266
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0226 0.0225
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Brugia malayi cathepsin L-like cysteine proteinase 0.0194 0.0803 0.0803
Loa Loa (eye worm) hypothetical protein 0.0463 0.2125 0.2125
Plasmodium falciparum metacaspase 1 0.0112 0.0401 0.1068
Loa Loa (eye worm) hypothetical protein 0.0244 0.1048 0.1048
Toxoplasma gondii cathepsin B 0.0773 0.3648 0.971
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0438 0.2001 0.2
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0026 0.0026
Entamoeba histolytica cysteine protease, putative 0.0796 0.3757 1
Entamoeba histolytica hypothetical protein 0.0037 0.0034 0.0086
Brugia malayi Cathepsin L-like precursor 0.0796 0.3757 0.3757
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0291 0.1278 0.1278
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0026 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0552 0.2559 0.6811
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0194 0.0803 0.2146
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0773 0.3648 0.3648
Onchocerca volvulus 0.0194 0.0803 0.2136
Brugia malayi fibroinase precursor 0.0194 0.0803 0.0803
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Entamoeba histolytica hypothetical protein 0.0037 0.0034 0.0086
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0026 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.0803 0.2134
Giardia lamblia Cathepsin B precursor 0.0773 0.3648 1
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Trypanosoma brucei metacaspase 0.0112 0.0401 0.0902
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0806 0.3808 0.3807
Loa Loa (eye worm) blistered cuticle protein 3 0.0106 0.0369 0.0369
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0796 0.3757 0.3757
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Toxoplasma gondii cathepsin CPC1 0.0194 0.0803 0.2138
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0312 0.031
Brugia malayi hypothetical protein 0.004 0.0048 0.0048
Plasmodium vivax unspecified product 0.0194 0.0803 0.2138
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0773 0.3648 0.9709
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0796 0.3757 1
Echinococcus granulosus caspase 2 0.0152 0.0598 0.0597
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0026 0.0058
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Schistosoma mansoni cathepsin F (C01 family) 0.0796 0.3757 0.3756
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Onchocerca volvulus Matrix metalloproteinase homolog 0.0048 0.0086 0.0226
Giardia lamblia Cathepsin L-like protease 0.0194 0.0803 0.2146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0803 0.0802
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.0231 0.0229
Brugia malayi Cathepsin L-like precursor 0.0796 0.3757 0.3757
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0312 0.0311
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0369 0.0369
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0002 0.0001
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0194 0.0803 0.0803
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0194 0.0803 0.0803
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0438 0.2001 0.4497
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0354 0.0354
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0112 0.0401 0.0401
Echinococcus granulosus cathepsin b 0.2067 1 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0354
Brugia malayi calpain 5 0.0072 0.0203 0.0203
Onchocerca volvulus Cell death protein 3 homolog 0.0152 0.0598 0.1591
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0112 0.0401 0.1068
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0194 0.0803 0.2138
Loa Loa (eye worm) hypothetical protein 0.0241 0.1034 0.1034
Brugia malayi Cathepsin L-like cysteine proteinase 0.0552 0.2559 0.2559
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0796
Schistosoma mansoni calpain (C02 family) 0.0103 0.0354 0.0353
Loa Loa (eye worm) hypothetical protein 0.0152 0.0598 0.0598
Echinococcus granulosus neuropeptide receptor A26 0.0486 0.2237 0.2236
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0002 0.0001
Trypanosoma brucei Calpain-like protein CALP1.3 0.0031 0.0002 0.0004
Echinococcus multilocularis calpain 7 (C02 family) 0.0103 0.0354 0.0352
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Trypanosoma cruzi major cysteine proteinase, putative 0.0335 0.1496 0.1496
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.0803 0.2134
Leishmania major calpain protease-like protein 0.0031 0.0002 0.0004
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0026 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0803 0.2134
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0272 0.1186 0.1185
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Echinococcus multilocularis cathepsin L 0.0438 0.2001 0.1999
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0401 0.1063
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0369 0.0369
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0161 0.0159
Giardia lamblia Cathepsin B precursor 0.0773 0.3648 1
Onchocerca volvulus Peroxidasin homolog 0.0106 0.0369 0.0979
Loa Loa (eye worm) hypothetical protein 0.0194 0.0803 0.0803
Echinococcus multilocularis calpain A 0.0291 0.1281 0.1279
Brugia malayi hypoxia-induced factor 1 0.0157 0.062 0.062
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0103 0.0354 0.0796
Brugia malayi Papain family cysteine protease containing protein 0.0438 0.2001 0.2001
Echinococcus granulosus geminin 0.0181 0.0742 0.074
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0226 0.0226
Giardia lamblia Cathepsin L-like protease 0.0194 0.0803 0.2146
Leishmania major cathepsin L-like protease 0.0796 0.3757 0.8443
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0438 0.2001 0.4497
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0121 0.0445 0.0445
Brugia malayi Cell death protein 3 precursor 0.0152 0.0598 0.0598
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0002 0.0004
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0026 0.0066
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0463 0.2125 0.2124
Schistosoma mansoni calpain-7 (C02 family) 0.0103 0.0354 0.0353
Trypanosoma cruzi cruzipain precursor, putative 0.0937 0.4449 0.4449
Trypanosoma cruzi cysteine peptidase, putative 0.0937 0.4449 0.4449
Echinococcus multilocularis caspase 0.0254 0.1098 0.1096
Onchocerca volvulus 0.0796 0.3757 1
Giardia lamblia Hypothetical protein 0.0194 0.0803 0.2146
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0796 0.3757 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0796 0.3757 0.3756
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0194 0.0803 0.2138
Plasmodium vivax proteasome subunit beta type-5, putative 0.0073 0.0209 0.0555
Giardia lamblia Cathepsin L precursor 0.0194 0.0803 0.2146
Plasmodium falciparum serine repeat antigen 2 0.0194 0.0803 0.2138
Trypanosoma cruzi metacaspase, putative 0.0112 0.0401 0.0401
Entamoeba histolytica cysteine protease, putative 0.0194 0.0803 0.2134
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0291 0.1278 0.1278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Loa Loa (eye worm) animal heme peroxidase 0.0106 0.0369 0.0369
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0002
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0354
Schistosoma mansoni hypothetical protein 0.0037 0.0034 0.0033
Onchocerca volvulus 0.0796 0.3757 1
Schistosoma mansoni survival motor neuron protein 0.0051 0.0101 0.01
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0354 0.0354
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0073 0.0209 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0194 0.0803 0.2138
Loa Loa (eye worm) hypothetical protein 0.0031 0.0002 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0312 0.031
Trypanosoma brucei metacaspase MCA3 0.0112 0.0401 0.0902
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.0803 0.2134
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0194 0.0803 0.2138
Brugia malayi Cathepsin L-like precursor 0.0552 0.2559 0.2559
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Echinococcus granulosus caspase 0.0254 0.1098 0.1096
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Echinococcus multilocularis proteasome (prosome, macropain) 0.0073 0.0209 0.0207
Brugia malayi Papain family cysteine protease containing protein 0.0438 0.2001 0.2001
Echinococcus multilocularis cathepsin L cysteine protease 0.0796 0.3757 0.3756
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0354 0.0796
Trypanosoma cruzi metacaspase 5, putative 0.0112 0.0401 0.0401
Echinococcus multilocularis calpain 5 0.0103 0.0354 0.0352
Brugia malayi hypothetical protein 0.025 0.1077 0.1077
Loa Loa (eye worm) hypothetical protein 0.0552 0.2559 0.2559
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Schistosoma mansoni hypothetical protein 0.004 0.0048 0.0047
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Plasmodium vivax calpain, putative 0.0103 0.0354 0.0943
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0438 0.2001 0.2
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0354 0.0354
Schistosoma mansoni Mername-AA248 (C02 family) 0.0103 0.0354 0.0353
Onchocerca volvulus 0.0796 0.3757 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0002
Loa Loa (eye worm) cathepsin B 0.0773 0.3648 0.3648
Entamoeba histolytica cysteine protease, putative 0.0194 0.0803 0.2134
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0002
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.0803 0.0803
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0026 0.0066
Trypanosoma brucei kinesin, putative 0.0072 0.0203 0.0456
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Giardia lamblia Cathepsin L precursor 0.0194 0.0803 0.2146
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Schistosoma mansoni calpain-7 (C02 family) 0.0103 0.0354 0.0353
Echinococcus granulosus cathepsin L cysteine proteinase 0.0796 0.3757 0.3756
Loa Loa (eye worm) animal heme peroxidase 0.0106 0.0369 0.0369
Schistosoma mansoni cathepsin F (C01 family) 0.0552 0.2559 0.2559
Plasmodium falciparum serine repeat antigen 9 0.0194 0.0803 0.2138
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0438 0.2001 0.5323
Echinococcus multilocularis caspase 8 0.0112 0.0401 0.0399
Trypanosoma cruzi metacaspase, putative 0.0112 0.0401 0.0401
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0796 0.3757 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Loa Loa (eye worm) animal heme peroxidase 0.0106 0.0369 0.0369
Trypanosoma brucei antigen, putative 0.0103 0.0354 0.0796
Schistosoma mansoni transient receptor potential channel 0.0078 0.0231 0.023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Trypanosoma cruzi cysteine peptidase, putative 0.0937 0.4449 0.4449
Brugia malayi Transient-receptor-potential like protein 0.0044 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0244 0.1048 0.1048
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Echinococcus multilocularis cathepsin b 0.2067 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0161 0.016
Echinococcus granulosus transient receptor potential ion channel A 0.0113 0.0407 0.0405
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0031 0.0002 0.0002
Echinococcus multilocularis calpain 0.0103 0.0354 0.0352
Brugia malayi Cathepsin L-like precursor 0.0244 0.1048 0.1048
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0226 0.0225
Onchocerca volvulus 0.0552 0.2559 0.6812
Plasmodium falciparum serine repeat antigen 6 0.0194 0.0803 0.2138
Entamoeba histolytica cysteine proteinase, putative 0.0796 0.3757 1
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0103 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0369 0.0369
Brugia malayi PAS domain containing protein 0.0051 0.0099 0.0099
Brugia malayi Papain family cysteine protease containing protein 0.0796 0.3757 0.3757
Onchocerca volvulus 0.0106 0.0369 0.0979
Giardia lamblia Cathepsin B precursor 0.0194 0.0803 0.2146
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0194 0.0803 0.0802
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.1028 0.1028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0026 0.0026
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.0231 0.0229
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0002 0.0002
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.0905 0.0905
Onchocerca volvulus Cathepsin L homolog 0.0796 0.3757 1
Giardia lamblia Cysteine protease 0.0194 0.0803 0.2146
Schistosoma mansoni caspase-7 (C14 family) 0.0254 0.1098 0.1097
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0026 0.0058
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0002 0.0002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2067 1 1
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0463 0.2125 0.2123
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0004
Leishmania major calpain family cysteine protease-like protein 0.0031 0.0002 0.0004
Onchocerca volvulus Chorion peroxidase homolog 0.0106 0.0369 0.0979
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0354
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0073 0.0209 0.0504
Plasmodium vivax SET domain protein, putative 0.0031 0.0002 0.0005
Loa Loa (eye worm) calpain D 0.0031 0.0002 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0312 0.0311
Trypanosoma brucei cysteine peptidase C (CPC) 0.0773 0.3648 0.8198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0244 0.1048 0.1048
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0796 0.3757 0.3757
Trypanosoma brucei Metacaspase-4 0.0112 0.0401 0.0902
Echinococcus granulosus cathepsin L 0.0438 0.2001 0.1999
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Echinococcus multilocularis neuropeptide receptor A26 0.0486 0.2237 0.2236
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0034 0.0033
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.0048 0.0046
Chlamydia trachomatis pyruvate kinase 0.0036 0.0026 0.5
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0026 0.0026
Trypanosoma cruzi metacaspase, putative 0.0112 0.0401 0.0401
Leishmania major cathepsin L-like protease 0.0796 0.3757 0.8443
Onchocerca volvulus 0.0037 0.0035 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0354 0.0354
Plasmodium falciparum cysteine proteinase falcipain 3 0.0796 0.3757 1
Echinococcus granulosus calpain 7 C02 family 0.0103 0.0354 0.0352
Echinococcus multilocularis transient receptor potential ion channel A 0.0113 0.0407 0.0405
Echinococcus granulosus pyruvate kinase 0.0036 0.0026 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0194 0.0803 0.2134
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Echinococcus multilocularis cathepsin b 0.2067 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0226 0.0226
Brugia malayi hypothetical protein 0.017 0.0685 0.0685
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0254 0.1098 0.1096
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0312 0.0312
Giardia lamblia Cathepsin B precursor 0.0194 0.0803 0.2146
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0073 0.0209 0.0208
Onchocerca volvulus 0.0169 0.0682 0.1813
Entamoeba histolytica cysteine protease, putative 0.0194 0.0803 0.2134
Leishmania major cathepsin L-like protease 0.0796 0.3757 0.8443
Brugia malayi cathepsin F-like cysteine proteinase 0.0194 0.0803 0.0803
Loa Loa (eye worm) calpain 0.0103 0.0354 0.0354
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Echinococcus granulosus cathepsin b 0.2067 1 1
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0246 0.1058 0.1058
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0226 0.0226
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0194 0.0803 0.2146
Trypanosoma cruzi cysteine protease, putative 0.0438 0.2001 0.2001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Trypanosoma brucei metacaspase MCA2 0.0112 0.0401 0.0902
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0194 0.0803 0.0803
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0161 0.016
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0079 0.0236 0.0235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Schistosoma mansoni hypothetical protein 0.0181 0.0742 0.0741
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0031 0.0002 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0401 0.1063
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0194 0.0803 0.0802
Trypanosoma cruzi major cysteine proteinase, putative 0.0194 0.0803 0.0803
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0026 0.0064
Loa Loa (eye worm) animal heme peroxidase 0.0106 0.0369 0.0369
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0002 0.0002
Leishmania major proteasome beta 5 subunit, putative 0.0073 0.0209 0.0469
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0194 0.0803 0.2134
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0194 0.0803 0.2146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Plasmodium falciparum proteasome subunit beta type-5 0.0073 0.0209 0.0555
Loa Loa (eye worm) hypothetical protein 0.2067 1 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Giardia lamblia Cysteine protease 0.0194 0.0803 0.2146
Toxoplasma gondii proteasome subunit beta type, putative 0.0073 0.0209 0.0555
Giardia lamblia Encystation-specific protease 0.0194 0.0803 0.2146
Trypanosoma cruzi metacaspase, putative 0.0112 0.0401 0.0401
Loa Loa (eye worm) hypothetical protein 0.0244 0.1048 0.1048
Echinococcus granulosus pyruvate kinase 0.0036 0.0026 0.0024
Plasmodium vivax vivapain-1 0.0438 0.2001 0.5326
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0002
Echinococcus granulosus cathepsin l1 0.0552 0.2559 0.2558
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.1028 0.1028
Echinococcus granulosus caspase 3 0.0142 0.0547 0.0545
Schistosoma mansoni transient receptor potential channel 0.0117 0.0426 0.0425
Onchocerca volvulus 0.004 0.0048 0.0124
Schistosoma mansoni hypothetical protein 0.0181 0.0742 0.0741
Leishmania major pyruvate kinase 0.0036 0.0026 0.0058
Echinococcus multilocularis cathepsin L 0.0194 0.0803 0.0802
Entamoeba histolytica hypothetical protein 0.0037 0.0034 0.0086
Schistosoma mansoni peptidylglycine monooxygenase 0.0246 0.1058 0.1058
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Brugia malayi calpain 5 0.0031 0.0002 0.0002
Entamoeba histolytica cysteine protease, putative 0.0194 0.0803 0.2134
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0438 0.2001 0.2
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0463 0.2125 0.2125
Brugia malayi calpain family protein 1 0.0272 0.1186 0.1186
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0291 0.1278 0.1277
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0161 0.0428
Loa Loa (eye worm) hypothetical protein 0.0246 0.1058 0.1058
Giardia lamblia Cysteine protease 0.0194 0.0803 0.2146
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0161 0.7387
Brugia malayi Cathepsin L-like precursor 0.0796 0.3757 0.3757

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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