Detailed information for compound 866927

Basic information

Technical information
  • TDR Targets ID: 866927
  • Name: N-[2-(butyl-ethylamino)ethyl]-2-[8-methyl-7-( pyrrolidine-1-carbonyl)-4,5-dihydrofuro[2,3-g ]indazol-2-yl]acetamide
  • MW: 455.593 | Formula: C25H37N5O3
  • H donors: 1 H acceptors: 3 LogP: 3.04 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(CCNC(=O)Cn1cc2c(n1)c1c(CC2)oc(c1C)C(=O)N1CCCC1)CC
  • InChi: 1S/C25H37N5O3/c1-4-6-12-28(5-2)15-11-26-21(31)17-30-16-19-9-10-20-22(23(19)27-30)18(3)24(33-20)25(32)29-13-7-8-14-29/h16H,4-15,17H2,1-3H3,(H,26,31)
  • InChiKey: JBCHTYJRWIJAQD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(butyl-ethyl-amino)ethyl]-2-[8-methyl-7-(pyrrolidine-1-carbonyl)-4,5-dihydrofuro[2,3-g]indazol-2-yl]acetamide
  • N-[2-(butyl-ethylamino)ethyl]-2-[8-methyl-7-(oxo-1-pyrrolidinylmethyl)-4,5-dihydrofuro[2,3-g]indazol-2-yl]acetamide
  • N-[2-(butyl-ethyl-amino)ethyl]-2-(8-methyl-7-pyrrolidin-1-ylcarbonyl-4,5-dihydrofuro[2,3-g]indazol-2-yl)ethanamide
  • E512-0794
  • NCGC00122177-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Mus musculus transient receptor potential cation channel, subfamily C, member 4 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Short transient receptor potential channel 5, putative Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Short transient receptor potential channel 5, putative Get druggable targets OG5_128782 All targets in OG5_128782
Brugia malayi Transient-receptor-potential like protein Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma japonicum ko:K05328 transient receptor potential cation channel, subfamily C,, putative Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus granulosus TRP transient receptor potential channel Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus transient receptor potential ion channel A Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni transient receptor potential channel 4 Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis transient receptor potential gamma protein Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis transient receptor potential ion channel A Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus granulosus transient receptor potential gamma protein Get druggable targets OG5_128782 All targets in OG5_128782
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni transient receptor potential channel Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis TRP (transient receptor potential) channel Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma japonicum ko:K05328 transient receptor potential cation channel, subfamily C,, putative Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma japonicum Transient receptor potential-gamma protein, putative Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis short transient receptor potential channel 6 transient receptor potential cation channel, subfamily C, member 4 890 aa 799 aa 31.2 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0773 0.3648 0.3648
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0194 0.0803 0.2146
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Onchocerca volvulus 0.0194 0.0803 0.2136
Brugia malayi fibroinase precursor 0.0194 0.0803 0.0803
Entamoeba histolytica hypothetical protein 0.0037 0.0034 0.0086
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0037 0.0034 0.0086
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0291 0.1278 0.1278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0552 0.2559 0.6811
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0026 0.0026
Brugia malayi Cathepsin L-like precursor 0.0796 0.3757 0.3757
Plasmodium falciparum metacaspase 1 0.0112 0.0401 0.1068
Loa Loa (eye worm) hypothetical protein 0.0244 0.1048 0.1048
Loa Loa (eye worm) hypothetical protein 0.0463 0.2125 0.2125
Brugia malayi cathepsin L-like cysteine proteinase 0.0194 0.0803 0.0803
Toxoplasma gondii cathepsin B 0.0773 0.3648 0.971
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0438 0.2001 0.2
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0026 0.0026
Entamoeba histolytica cysteine protease, putative 0.0796 0.3757 1
Plasmodium falciparum serine repeat antigen 1 0.0194 0.0803 0.2138
Onchocerca volvulus 0.0051 0.0101 0.0266
Echinococcus multilocularis cysteine protease 0.0796 0.3757 0.3756
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0073 0.0209 1
Loa Loa (eye worm) calpain 5 0.0072 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0226 0.0225
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0026 0.0058
Echinococcus granulosus caspase 2 0.0152 0.0598 0.0597
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Schistosoma mansoni cathepsin F (C01 family) 0.0796 0.3757 0.3756
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Toxoplasma gondii cathepsin CPC1 0.0194 0.0803 0.2138
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0796 0.3757 1
Plasmodium vivax unspecified product 0.0194 0.0803 0.2138
Brugia malayi hypothetical protein 0.004 0.0048 0.0048
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0312 0.031
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0773 0.3648 0.9709
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0806 0.3808 0.3807
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Trypanosoma brucei metacaspase 0.0112 0.0401 0.0902
Loa Loa (eye worm) blistered cuticle protein 3 0.0106 0.0369 0.0369
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0796 0.3757 0.3757
Giardia lamblia Cathepsin B precursor 0.0773 0.3648 1
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0026 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.0803 0.2134
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0796
Schistosoma mansoni calpain (C02 family) 0.0103 0.0354 0.0353
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0112 0.0401 0.1068
Brugia malayi calpain 5 0.0072 0.0203 0.0203
Onchocerca volvulus Cell death protein 3 homolog 0.0152 0.0598 0.1591
Loa Loa (eye worm) hypothetical protein 0.0241 0.1034 0.1034
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0194 0.0803 0.2138
Brugia malayi Cathepsin L-like cysteine proteinase 0.0552 0.2559 0.2559
Echinococcus granulosus neuropeptide receptor A26 0.0486 0.2237 0.2236
Loa Loa (eye worm) hypothetical protein 0.0152 0.0598 0.0598
Loa Loa (eye worm) hypothetical protein 0.0194 0.0803 0.0803
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0194 0.0803 0.0803
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0112 0.0401 0.0401
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0354 0.0354
Echinococcus granulosus cathepsin b 0.2067 1 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0354
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0438 0.2001 0.4497
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0312 0.0311
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0369 0.0369
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0002 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0803 0.0802
Onchocerca volvulus Matrix metalloproteinase homolog 0.0048 0.0086 0.0226
Giardia lamblia Cathepsin L-like protease 0.0194 0.0803 0.2146
Brugia malayi Cathepsin L-like precursor 0.0796 0.3757 0.3757
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.0231 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0401 0.1063
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0161 0.0159
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0369 0.0369
Giardia lamblia Cathepsin B precursor 0.0773 0.3648 1
Onchocerca volvulus Peroxidasin homolog 0.0106 0.0369 0.0979
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0272 0.1186 0.1185
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0803 0.2134
Echinococcus multilocularis cathepsin L 0.0438 0.2001 0.1999
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Trypanosoma brucei Calpain-like protein CALP1.3 0.0031 0.0002 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0002 0.0001
Echinococcus multilocularis calpain 7 (C02 family) 0.0103 0.0354 0.0352
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0026 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.0803 0.2134
Trypanosoma cruzi major cysteine proteinase, putative 0.0335 0.1496 0.1496
Leishmania major calpain protease-like protein 0.0031 0.0002 0.0004
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0463 0.2125 0.2124
Schistosoma mansoni calpain-7 (C02 family) 0.0103 0.0354 0.0353
Trypanosoma cruzi cruzipain precursor, putative 0.0937 0.4449 0.4449
Trypanosoma cruzi cysteine peptidase, putative 0.0937 0.4449 0.4449
Echinococcus multilocularis caspase 0.0254 0.1098 0.1096
Onchocerca volvulus 0.0796 0.3757 1
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0002 0.0004
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0026 0.0066
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0121 0.0445 0.0445
Brugia malayi Cell death protein 3 precursor 0.0152 0.0598 0.0598
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0226 0.0226
Echinococcus granulosus geminin 0.0181 0.0742 0.074
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0438 0.2001 0.4497
Giardia lamblia Cathepsin L-like protease 0.0194 0.0803 0.2146
Leishmania major cathepsin L-like protease 0.0796 0.3757 0.8443
Echinococcus multilocularis calpain A 0.0291 0.1281 0.1279
Loa Loa (eye worm) hypothetical protein 0.0194 0.0803 0.0803
Brugia malayi hypoxia-induced factor 1 0.0157 0.062 0.062
Brugia malayi Papain family cysteine protease containing protein 0.0438 0.2001 0.2001
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0103 0.0354 0.0796
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0037 0.0034 0.0033
Onchocerca volvulus 0.0796 0.3757 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0354
Loa Loa (eye worm) animal heme peroxidase 0.0106 0.0369 0.0369
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0291 0.1278 0.1278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Plasmodium falciparum serine repeat antigen 2 0.0194 0.0803 0.2138
Giardia lamblia Cathepsin L precursor 0.0194 0.0803 0.2146
Plasmodium vivax proteasome subunit beta type-5, putative 0.0073 0.0209 0.0555
Trypanosoma cruzi metacaspase, putative 0.0112 0.0401 0.0401
Entamoeba histolytica cysteine protease, putative 0.0194 0.0803 0.2134
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0796 0.3757 1
Giardia lamblia Hypothetical protein 0.0194 0.0803 0.2146
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0796 0.3757 0.3756
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0194 0.0803 0.2138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Brugia malayi Cathepsin L-like precursor 0.0552 0.2559 0.2559
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Trypanosoma brucei metacaspase MCA3 0.0112 0.0401 0.0902
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0312 0.031
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0194 0.0803 0.2138
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.0803 0.2134
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0073 0.0209 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0194 0.0803 0.2138
Loa Loa (eye worm) hypothetical protein 0.0031 0.0002 0.0002
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0354 0.0354
Schistosoma mansoni survival motor neuron protein 0.0051 0.0101 0.01
Schistosoma mansoni Mername-AA248 (C02 family) 0.0103 0.0354 0.0353
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0354 0.0354
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0002
Onchocerca volvulus 0.0796 0.3757 1
Plasmodium vivax calpain, putative 0.0103 0.0354 0.0943
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0438 0.2001 0.2
Loa Loa (eye worm) hypothetical protein 0.0552 0.2559 0.2559
Schistosoma mansoni hypothetical protein 0.004 0.0048 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0796 0.3757 0.3756
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0354 0.0796
Echinococcus multilocularis calpain 5 0.0103 0.0354 0.0352
Brugia malayi hypothetical protein 0.025 0.1077 0.1077
Trypanosoma cruzi metacaspase 5, putative 0.0112 0.0401 0.0401
Echinococcus granulosus caspase 0.0254 0.1098 0.1096
Brugia malayi Papain family cysteine protease containing protein 0.0438 0.2001 0.2001
Echinococcus multilocularis proteasome (prosome, macropain) 0.0073 0.0209 0.0207
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Echinococcus multilocularis caspase 8 0.0112 0.0401 0.0399
Trypanosoma cruzi metacaspase, putative 0.0112 0.0401 0.0401
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0796 0.3757 1
Loa Loa (eye worm) animal heme peroxidase 0.0106 0.0369 0.0369
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0438 0.2001 0.5323
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Giardia lamblia Cathepsin L precursor 0.0194 0.0803 0.2146
Loa Loa (eye worm) animal heme peroxidase 0.0106 0.0369 0.0369
Schistosoma mansoni cathepsin F (C01 family) 0.0552 0.2559 0.2559
Plasmodium falciparum serine repeat antigen 9 0.0194 0.0803 0.2138
Schistosoma mansoni calpain-7 (C02 family) 0.0103 0.0354 0.0353
Echinococcus granulosus cathepsin L cysteine proteinase 0.0796 0.3757 0.3756
Entamoeba histolytica cysteine protease, putative 0.0194 0.0803 0.2134
Loa Loa (eye worm) cathepsin B 0.0773 0.3648 0.3648
Trypanosoma brucei kinesin, putative 0.0072 0.0203 0.0456
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.0803 0.0803
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0002
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0026 0.0066
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0369 0.0369
Brugia malayi PAS domain containing protein 0.0051 0.0099 0.0099
Brugia malayi Papain family cysteine protease containing protein 0.0796 0.3757 0.3757
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0103 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Plasmodium falciparum serine repeat antigen 6 0.0194 0.0803 0.2138
Entamoeba histolytica cysteine proteinase, putative 0.0796 0.3757 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0161 0.016
Echinococcus granulosus transient receptor potential ion channel A 0.0113 0.0407 0.0405
Echinococcus multilocularis cathepsin b 0.2067 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0226 0.0225
Onchocerca volvulus 0.0552 0.2559 0.6812
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0031 0.0002 0.0002
Brugia malayi Cathepsin L-like precursor 0.0244 0.1048 0.1048
Echinococcus multilocularis calpain 0.0103 0.0354 0.0352
Trypanosoma cruzi cysteine peptidase, putative 0.0937 0.4449 0.4449
Brugia malayi Transient-receptor-potential like protein 0.0044 0.0065 0.0065
Schistosoma mansoni transient receptor potential channel 0.0078 0.0231 0.023
Trypanosoma brucei antigen, putative 0.0103 0.0354 0.0796
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0244 0.1048 0.1048
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2067 1 1
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0463 0.2125 0.2123
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0002 0.0002
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0026 0.0058
Onchocerca volvulus Cathepsin L homolog 0.0796 0.3757 1
Giardia lamblia Cysteine protease 0.0194 0.0803 0.2146
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.0905 0.0905
Schistosoma mansoni caspase-7 (C14 family) 0.0254 0.1098 0.1097
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0002 0.0002
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.0231 0.0229
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0026 0.0026
Giardia lamblia Cathepsin B precursor 0.0194 0.0803 0.2146
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0194 0.0803 0.0802
Onchocerca volvulus 0.0106 0.0369 0.0979
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.1028 0.1028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.0048 0.0046
Trypanosoma cruzi metacaspase, putative 0.0112 0.0401 0.0401
Leishmania major cathepsin L-like protease 0.0796 0.3757 0.8443
Chlamydia trachomatis pyruvate kinase 0.0036 0.0026 0.5
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0026 0.0026
Echinococcus multilocularis neuropeptide receptor A26 0.0486 0.2237 0.2236
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0034 0.0033
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0796 0.3757 0.3757
Trypanosoma brucei Metacaspase-4 0.0112 0.0401 0.0902
Echinococcus granulosus cathepsin L 0.0438 0.2001 0.1999
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Loa Loa (eye worm) calpain D 0.0031 0.0002 0.0002
Plasmodium vivax SET domain protein, putative 0.0031 0.0002 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0244 0.1048 0.1048
Trypanosoma brucei cysteine peptidase C (CPC) 0.0773 0.3648 0.8198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0312 0.0311
Leishmania major calpain family cysteine protease-like protein 0.0031 0.0002 0.0004
Onchocerca volvulus Chorion peroxidase homolog 0.0106 0.0369 0.0979
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0004
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0073 0.0209 0.0504
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0354
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0194 0.0803 0.2134
Echinococcus granulosus calpain 7 C02 family 0.0103 0.0354 0.0352
Echinococcus multilocularis transient receptor potential ion channel A 0.0113 0.0407 0.0405
Echinococcus granulosus pyruvate kinase 0.0036 0.0026 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Onchocerca volvulus 0.0037 0.0035 0.0089
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0354 0.0354
Plasmodium falciparum cysteine proteinase falcipain 3 0.0796 0.3757 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0194 0.0803 0.0803
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0161 0.016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Schistosoma mansoni hypothetical protein 0.0181 0.0742 0.0741
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0079 0.0236 0.0235
Trypanosoma cruzi cysteine protease, putative 0.0438 0.2001 0.2001
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0194 0.0803 0.2146
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0226 0.0226
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Trypanosoma brucei metacaspase MCA2 0.0112 0.0401 0.0902
Brugia malayi cathepsin F-like cysteine proteinase 0.0194 0.0803 0.0803
Leishmania major cathepsin L-like protease 0.0796 0.3757 0.8443
Onchocerca volvulus 0.0169 0.0682 0.1813
Entamoeba histolytica cysteine protease, putative 0.0194 0.0803 0.2134
Loa Loa (eye worm) calpain 0.0103 0.0354 0.0354
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0246 0.1058 0.1058
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Echinococcus granulosus cathepsin b 0.2067 1 1
Echinococcus multilocularis cathepsin b 0.2067 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0226 0.0226
Brugia malayi hypothetical protein 0.017 0.0685 0.0685
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0254 0.1098 0.1096
Giardia lamblia Cathepsin B precursor 0.0194 0.0803 0.2146
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0073 0.0209 0.0208
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0312 0.0312
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0002
Plasmodium vivax vivapain-1 0.0438 0.2001 0.5326
Echinococcus granulosus cathepsin l1 0.0552 0.2559 0.2558
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.1028 0.1028
Giardia lamblia Encystation-specific protease 0.0194 0.0803 0.2146
Trypanosoma cruzi metacaspase, putative 0.0112 0.0401 0.0401
Giardia lamblia Cysteine protease 0.0194 0.0803 0.2146
Toxoplasma gondii proteasome subunit beta type, putative 0.0073 0.0209 0.0555
Echinococcus granulosus pyruvate kinase 0.0036 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0244 0.1048 0.1048
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0194 0.0803 0.2146
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0194 0.0803 0.2134
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Plasmodium falciparum proteasome subunit beta type-5 0.0073 0.0209 0.0555
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Loa Loa (eye worm) hypothetical protein 0.2067 1 1
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0026 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0401 0.1063
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0031 0.0002 0.0004
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0194 0.0803 0.0802
Trypanosoma cruzi major cysteine proteinase, putative 0.0194 0.0803 0.0803
Loa Loa (eye worm) hypothetical protein 0.0031 0.0002 0.0002
Leishmania major proteasome beta 5 subunit, putative 0.0073 0.0209 0.0469
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Loa Loa (eye worm) animal heme peroxidase 0.0106 0.0369 0.0369
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0002 0.0001
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0161 0.0428
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0291 0.1278 0.1277
Loa Loa (eye worm) hypothetical protein 0.0246 0.1058 0.1058
Giardia lamblia Cysteine protease 0.0194 0.0803 0.2146
Brugia malayi calpain family protein 1 0.0272 0.1186 0.1186
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0161 0.7387
Brugia malayi Cathepsin L-like precursor 0.0796 0.3757 0.3757
Entamoeba histolytica cysteine protease, putative 0.0194 0.0803 0.2134
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0438 0.2001 0.2
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0463 0.2125 0.2125
Brugia malayi calpain 5 0.0031 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0037 0.0034 0.0086
Echinococcus multilocularis cathepsin L 0.0194 0.0803 0.0802
Schistosoma mansoni peptidylglycine monooxygenase 0.0246 0.1058 0.1058
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Schistosoma mansoni hypothetical protein 0.0181 0.0742 0.0741
Schistosoma mansoni transient receptor potential channel 0.0117 0.0426 0.0425
Echinococcus granulosus caspase 3 0.0142 0.0547 0.0545
Onchocerca volvulus 0.004 0.0048 0.0124
Leishmania major pyruvate kinase 0.0036 0.0026 0.0058
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.0048 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0226 0.0225
Trypanosoma brucei calpain, putative 0.0031 0.0002 0.0004
Echinococcus multilocularis pyruvate kinase 0.0036 0.0026 0.0024
Giardia lamblia Cathepsin L precursor 0.0194 0.0803 0.2146
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0073 0.0209 0.055
Toxoplasma gondii cathepsin CPL 0.0796 0.3757 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Loa Loa (eye worm) hypothetical protein 0.0272 0.1186 0.1186
Brugia malayi cathepsin L-like precursor 0.0552 0.2559 0.2559
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0354 0.0796
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Plasmodium vivax unspecified product 0.0438 0.2001 0.5326
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0194 0.0803 0.0803
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Brugia malayi cathepsin Z-like cysteine proteinase 0.0194 0.0803 0.0803
Giardia lamblia Cathepsin B precursor 0.0773 0.3648 1
Plasmodium vivax vivapain-3 0.0438 0.2001 0.5326
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0796 0.3757 0.3756
Loa Loa (eye worm) ctsf protein 0.0796 0.3757 0.3757
Onchocerca volvulus Peroxidasin homolog 0.0106 0.0369 0.0979
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0803 0.2134
Loa Loa (eye worm) hypothetical protein 0.0036 0.0026 0.0026
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0112 0.0401 0.1068
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.004 0.0045 0.0045
Trypanosoma cruzi cysteine proteinase, putative 0.0438 0.2001 0.2001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0401 0.1063
Entamoeba histolytica protein kinase, putative 0.0072 0.0203 0.0535
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0194 0.0803 0.2134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0194 0.0803 0.2134
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0194 0.0803 0.2138
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0194 0.0803 0.2138
Echinococcus granulosus calpain 5 0.0103 0.0354 0.0352
Loa Loa (eye worm) hypothetical protein 0.0194 0.0803 0.0803
Schistosoma mansoni transient receptor potential channel 4 0.0117 0.0426 0.0425
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0002 0.0005
Entamoeba histolytica cysteine proteinase, putative 0.0438 0.2001 0.5323
Plasmodium falciparum serine repeat antigen 7 0.0194 0.0803 0.2138
Loa Loa (eye worm) hypothetical protein 0.0169 0.0682 0.0682
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0226 0.0225
Plasmodium falciparum calpain 0.0031 0.0002 0.0005
Onchocerca volvulus 0.0796 0.3757 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0194 0.0803 0.0803
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0194 0.0803 0.2134
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.0803 0.2134
Giardia lamblia Cathepsin B precursor 0.0194 0.0803 0.2146
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0002 0.0001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0034 0.0033
Trypanosoma cruzi cysteine peptidase, putative 0.0937 0.4449 0.4449
Onchocerca volvulus Dual oxidase homolog 0.0106 0.0369 0.0979
Echinococcus granulosus calpain A 0.0291 0.1281 0.1279
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0026 0.0066
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0803 0.0802
Leishmania major cathepsin L-like protease 0.0937 0.4449 1
Leishmania major cysteine peptidase A (CPA) 0.0796 0.3757 0.8443
Plasmodium falciparum serine repeat antigen 3 0.0194 0.0803 0.2138
Loa Loa (eye worm) calpain family protein 1 0.02 0.0833 0.0833
Loa Loa (eye worm) cysteine protease 0.0796 0.3757 0.3757
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Onchocerca volvulus Cathepsin L homolog 0.0194 0.0803 0.2136
Giardia lamblia Cathepsin B precursor 0.0194 0.0803 0.2146
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2067 1 1
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0369 0.0369
Leishmania major hypothetical protein, unknown function 0.0031 0.0002 0.0004
Schistosoma mansoni cathepsin s 0.0244 0.1048 0.1047
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0194 0.0803 0.2138
Brugia malayi MH2 domain containing protein 0.024 0.1028 0.1028
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0112 0.0401 0.04
Onchocerca volvulus 0.0106 0.0369 0.0979
Mycobacterium ulcerans proteasome PrcB 0.0073 0.0209 1
Entamoeba histolytica cysteine proteinase, putative 0.0438 0.2001 0.5323
Brugia malayi Cathepsin L-like precursor 0.0796 0.3757 0.3757
Leishmania major metacaspase, putative 0.0112 0.0401 0.0902
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Leishmania major pyruvate kinase 0.0036 0.0026 0.0058
Leishmania major kinesin, putative 0.0072 0.0203 0.0456
Schistosoma mansoni hypothetical protein 0.0031 0.0002 0.0001
Schistosoma mansoni dopamine-beta-monooxygenase 0.0246 0.1058 0.1058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Loa Loa (eye worm) hypothetical protein 0.0552 0.2559 0.2559
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0803 0.0802
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0254 0.1098 0.1096
Trypanosoma cruzi metacaspase 5, putative 0.0112 0.0401 0.0401
Echinococcus multilocularis neuropeptide s receptor 0.0486 0.2237 0.2236
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0099 0.0098
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0796
Loa Loa (eye worm) hypothetical protein 0.0552 0.2559 0.2559
Brugia malayi Blistered cuticle protein 3 0.0106 0.0369 0.0369
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0438 0.2001 0.2001
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0161 0.0362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0803 0.2134
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0161 0.7387
Onchocerca volvulus 0.0796 0.3757 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0438 0.2001 0.5326
Echinococcus multilocularis peroxidasin 0.0106 0.0369 0.0367
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0194 0.0803 0.0802
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Brugia malayi calpain 7 0.0103 0.0354 0.0354
Brugia malayi cathepsin Z-like cysteine proteinase 0.0194 0.0803 0.0803
Brugia malayi Pre-SET motif family protein 0.0215 0.0905 0.0905
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.0231 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0401 0.1063
Loa Loa (eye worm) fibroinase 0.0796 0.3757 0.3757
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0026 0.0069
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0401 0.1063
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0194 0.0803 0.2138
Plasmodium vivax metacaspase 1, putative 0.0112 0.0401 0.1068
Schistosoma mansoni cathepsin C 0.0194 0.0803 0.0802
Echinococcus multilocularis transient receptor potential gamma protein 0.0117 0.0426 0.0424
Echinococcus multilocularis microtubule associated protein 2 0.0739 0.348 0.3479
Plasmodium falciparum serine repeat antigen 5 0.0194 0.0803 0.2138
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0312 0.031
Onchocerca volvulus 0.0796 0.3757 1
Loa Loa (eye worm) hypothetical protein 0.0796 0.3757 0.3757
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0161 0.7387
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2067 1 1
Onchocerca volvulus 0.0031 0.0002 0.0002
Schistosoma mansoni pyruvate kinase 0.0036 0.0026 0.0025
Schistosoma mansoni caspase-7 (C14 family) 0.0152 0.0598 0.0597
Echinococcus granulosus cysteine protease 0.0438 0.2001 0.1999
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.0803 0.0803
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0312 0.0312
Brugia malayi calpain family protein 1 0.0272 0.1186 0.1186
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0803 0.0802
Echinococcus granulosus cathepsin l1 0.0796 0.3757 0.3756
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0002
Trypanosoma brucei Calpain-like protein 1.2 0.0031 0.0002 0.0004
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.1077 0.1076
Plasmodium falciparum pyruvate kinase 0.0036 0.0026 0.0069
Plasmodium falciparum serine repeat antigen 4 0.0194 0.0803 0.2138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0112 0.0401 0.1068
Loa Loa (eye worm) hypothetical protein 0.025 0.1077 0.1077
Schistosoma mansoni cathepsin F (C01 family) 0.0796 0.3757 0.3756
Loa Loa (eye worm) calpain family protein 1 0.0272 0.1186 0.1186
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.0231 0.0229
Echinococcus granulosus survival motor neuron protein 1 0.025 0.1077 0.1076
Echinococcus granulosus neuropeptide s receptor 0.0486 0.2237 0.2236
Plasmodium vivax unspecified product 0.0244 0.1048 0.2789
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0002 0.0002
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0194 0.0803 0.2138
Leishmania major hypothetical protein, conserved 0.0031 0.0002 0.0004
Schistosoma mansoni microtubule-associated protein tau 0.0739 0.348 0.3479
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0803 0.2134
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0073 0.0209 0.0209
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0796
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.02 0.0833 0.0833
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0773 0.3648 0.8198
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Echinococcus granulosus TRP transient receptor potential channel 0.0044 0.0065 0.0063
Plasmodium falciparum metacaspase-like protein 0.0112 0.0401 0.1068
Echinococcus granulosus microtubule associated protein 2 0.0739 0.348 0.3479
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0194 0.0803 0.2138
Echinococcus granulosus proteasome prosome macropain 0.0073 0.0209 0.0207
Schistosoma mansoni calpain C (C02 family) 0.0103 0.0354 0.0353
Loa Loa (eye worm) hypothetical protein 0.0112 0.0401 0.0401
Schistosoma mansoni peroxidasin 0.0106 0.0369 0.0368
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0226 0.0224
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0463 0.2125 0.2123
Echinococcus granulosus cathepsin L cysteine protease 0.0438 0.2001 0.1999
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0034 0.0033
Schistosoma mansoni cathepsin S (C01 family) 0.0194 0.0803 0.0802
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0354 0.0796
Schistosoma mansoni transient receptor potential channel 0.0078 0.0231 0.023
Entamoeba histolytica cysteine protease, putative 0.0194 0.0803 0.2134
Onchocerca volvulus Peroxidase homolog 0.0106 0.0369 0.0979
Brugia malayi Cathepsin L-like precursor 0.0796 0.3757 0.3757
Loa Loa (eye worm) hypothetical protein 0.0194 0.0803 0.0803
Schistosoma mansoni cathepsin B (C01 family) 0.0194 0.0803 0.0802
Trypanosoma cruzi cysteine peptidase, putative 0.0438 0.2001 0.2001
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0401 0.1063
Entamoeba histolytica cysteine proteinase 1, putative 0.0438 0.2001 0.5323
Trypanosoma brucei metacaspase 5, putative 0.0112 0.0401 0.0902
Brugia malayi cathepsin L precursor 0.0194 0.0803 0.0803
Echinococcus granulosus calpain A 0.0103 0.0354 0.0352
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0073 0.0209 0.055
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Brugia malayi Peroxidasin 0.0106 0.0369 0.0369
Echinococcus granulosus caspase 8 0.0112 0.0401 0.0399
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Giardia lamblia Hypothetical protein 0.0194 0.0803 0.2146
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0044 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.017 0.0685 0.0685
Schistosoma mansoni caspase-3 (C14 family) 0.0254 0.1098 0.1097
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0194 0.0803 0.0802
Echinococcus multilocularis caspase 2 0.0152 0.0598 0.0597
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.0803 0.0803
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0035 0.0035
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Echinococcus granulosus cathepsin l cysteine peptidase 0.0796 0.3757 0.3756
Echinococcus granulosus cathepsin L 0.0194 0.0803 0.0802
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Trypanosoma cruzi cysteine peptidase, putative 0.0244 0.1048 0.1048
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0161 0.7387
Entamoeba histolytica cysteine proteinase, putative 0.0438 0.2001 0.5323
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0796 0.3757 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0291 0.1278 0.1277
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0312 0.0311
Onchocerca volvulus Cathepsin L homolog 0.0796 0.3757 1
Brugia malayi Proteasome A-type and B-type family protein 0.0073 0.0209 0.0209
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Echinococcus multilocularis cysteine protease 0.0796 0.3757 0.3756
Trypanosoma cruzi cysteine proteinase, putative 0.0438 0.2001 0.2001
Echinococcus granulosus calpain 0.0103 0.0354 0.0352
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0796
Loa Loa (eye worm) matrixin family protein 0.0048 0.0086 0.0086
Entamoeba histolytica calpain large subunit domain III containing protein 0.0072 0.0203 0.0535
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0079 0.0236 0.0235
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0125 0.0464 0.0464
Echinococcus multilocularis caspase 3 0.0142 0.0547 0.0545
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0026 0.0026
Entamoeba histolytica cysteine proteinase, putative 0.0552 0.2559 0.6811
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0194 0.0803 0.2138
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0773 0.3648 0.3647
Schistosoma mansoni peroxidasin 0.0106 0.0369 0.0368
Toxoplasma gondii hypothetical protein 0.0031 0.0002 0.0005
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0803 0.2134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0194 0.0803 0.2134
Trypanosoma brucei cysteine peptidase, putative 0.0031 0.0002 0.0004
Trypanosoma cruzi cysteine peptidase, putative 0.0796 0.3757 0.3757
Onchocerca volvulus Peroxidase homolog 0.0106 0.0369 0.0979
Brugia malayi Cathepsin L-like precursor 0.0552 0.2559 0.2559
Loa Loa (eye worm) hypothetical protein 0.0074 0.0212 0.0212
Onchocerca volvulus Matrilysin homolog 0.0048 0.0086 0.0226
Brugia malayi Matrixin family protein 0.0052 0.0107 0.0107
Giardia lamblia Cathepsin L precursor 0.0194 0.0803 0.2146
Onchocerca volvulus 0.0106 0.0369 0.0979
Giardia lamblia Cathepsin L precursor 0.0194 0.0803 0.2146
Entamoeba histolytica cysteine proteinase, putative 0.0796 0.3757 1
Brugia malayi RNA binding protein 0.0076 0.0226 0.0226
Trypanosoma brucei Calpain-like protein 2 0.0031 0.0002 0.0004
Toxoplasma gondii cathepsin CPC2 0.0194 0.0803 0.2138
Brugia malayi Hemopexin family protein 0.0031 0.0001 0.0001
Leishmania major cathepsin L-like protease 0.0796 0.3757 0.8443
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2067 1 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0026 0.0026
Onchocerca volvulus 0.0244 0.1051 0.2795
Leishmania major cathepsin L-like protease 0.0937 0.4449 1
Plasmodium vivax vivapain-2 0.0796 0.3757 1
Entamoeba histolytica cysteine proteinase, putative 0.0438 0.2001 0.5323
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0194 0.0803 0.2134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0194 0.0803 0.2134
Echinococcus multilocularis pyruvate kinase 0.0036 0.0026 0.0024
Leishmania major cathepsin L-like protease 0.0937 0.4449 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0161 0.0159
Echinococcus granulosus tar DNA binding protein 0.0076 0.0226 0.0224
Loa Loa (eye worm) hypothetical protein 0.0194 0.0803 0.0803
Plasmodium vivax vivapain-2 0.0796 0.3757 1
Giardia lamblia Cysteine protease 0.0194 0.0803 0.2146
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0354 0.0796
Echinococcus granulosus transient receptor potential gamma protein 0.0117 0.0426 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Loa Loa (eye worm) matrixin family protein 0.0052 0.0107 0.0107
Entamoeba histolytica cysteine protease, putative 0.0194 0.0803 0.2134
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Plasmodium falciparum serine repeat antigen 8 0.0194 0.0803 0.2138
Echinococcus granulosus single minded 2 0.0037 0.0035 0.0033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0312 0.031
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0194 0.0803 0.2138
Leishmania major cathepsin L-like protease 0.0796 0.3757 0.8443
Loa Loa (eye worm) hypothetical protein 0.0044 0.0065 0.0065
Plasmodium vivax serine-repeat antigen (SERA) 0.0194 0.0803 0.2138
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2067 1 1
Onchocerca volvulus 0.0796 0.3757 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0354
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0803 0.2134
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0194 0.0803 0.2134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Entamoeba histolytica hypothetical protein 0.0194 0.0803 0.2134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0803 0.2134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0803 0.2134
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Giardia lamblia Cathepsin L precursor 0.0194 0.0803 0.2146
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0035 0.047
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0194 0.0803 0.2138
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Trypanosoma cruzi kinesin, putative 0.0072 0.0203 0.0203
Trypanosoma cruzi cruzipain precursor, putative 0.0244 0.1048 0.1048
Schistosoma mansoni calpain-2 (C02 family) 0.0031 0.0002 0.0001
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0101 0.0101
Trypanosoma cruzi conserved protein 0.0031 0.0002 0.0002
Schistosoma mansoni single-minded 0.0051 0.0099 0.0098
Trypanosoma brucei Calpain-like protein 1.1 0.0031 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0117 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0194 0.0803 0.0803
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0031 0.0002 0.0005
Loa Loa (eye worm) RNA binding protein 0.0076 0.0226 0.0226
Echinococcus multilocularis hypothetical protein 0.0103 0.0354 0.0352
Echinococcus granulosus peroxidasin 0.0106 0.0369 0.0367
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0401 0.1068
Trypanosoma brucei calpain, putative 0.0031 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0438 0.2001 0.5323
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0035 0.0033
Schistosoma mansoni pyruvate kinase 0.0036 0.0026 0.0025
Entamoeba histolytica cysteine proteinase 2 0.0438 0.2001 0.5323
Onchocerca volvulus Cathepsin F homolog 0.0796 0.3757 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0194 0.0803 0.2146
Giardia lamblia Cathepsin B precursor 0.0194 0.0803 0.2146
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Trypanosoma cruzi kinesin, putative 0.0072 0.0203 0.0203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0552 0.2559 0.6811
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0244 0.1048 0.1048
Brugia malayi TAR-binding protein 0.0076 0.0226 0.0226
Echinococcus multilocularis geminin 0.0181 0.0742 0.074
Entamoeba histolytica hypothetical protein 0.0037 0.0034 0.0086
Brugia malayi hypothetical protein 0.0106 0.0369 0.0369
Brugia malayi calpain D 0.0031 0.0002 0.0002
Trypanosoma brucei hypothetical protein 0.0031 0.0002 0.0004
Plasmodium vivax serine-repeat antigen (SERA) 0.0194 0.0803 0.2138
Brugia malayi Cathepsin L-like precursor 0.0796 0.3757 0.3757
Brugia malayi Pre-SET motif family protein 0.0031 0.0002 0.0002
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0073 0.0209 0.0209
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0194 0.0803 0.2138
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0693 0.3252 0.3252
Loa Loa (eye worm) hypoxia-induced factor 1 0.0157 0.062 0.062
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0073 0.0209 0.0469
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0369 0.0369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0796 0.3757 0.3756
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0026 0.0026
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0803 0.0802
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0073 0.0209 0.0209
Trichomonas vaginalis set domain proteins, putative 0.0244 0.1051 0.2793
Brugia malayi cathepsin F-like cysteine proteinase 0.0244 0.1048 0.1048
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0354 0.0354
Brugia malayi hypothetical protein 0.0037 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0051 0.0101 0.01
Echinococcus multilocularis calpain family protein 1, d 0.02 0.0833 0.0832
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0226 0.0225

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 0.2667 uM PUBCHEM_BIOASSAY: Confirmation dose response assay for compounds that activate transient receptor potential cation channel C4 (TRPC4). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2237, AID2259] ChEMBL. No reference
Potency (functional) 0.5012 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.7865 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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