Detailed information for compound 1024253

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 365.43 | Formula: C23H19N5
  • H donors: 2 H acceptors: 2 LogP: 4.63 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc2c(cccc2c2c1nn(c2)c1ccccc1)NCc1ccccc1
  • InChi: 1S/C23H19N5/c24-23-22-19(15-28(27-22)17-10-5-2-6-11-17)18-12-7-13-20(21(18)26-23)25-14-16-8-3-1-4-9-16/h1-13,15,25H,14H2,(H2,24,26)
  • InChiKey: STNHPPUKBIEADN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein adenosine A1 receptor 326 aa 305 aa 21.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0495 0.1744
Entamoeba histolytica cysteine proteinase 1, putative 0.0054 0.014 0.105
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0061 0.0186 0.0615
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1403 0.8691 1
Trypanosoma cruzi cysteine proteinase, putative 0.0054 0.014 0.0141
Trichomonas vaginalis caltractin, putative 0.0044 0.008 0.0227
Echinococcus granulosus cathepsin l1 0.0064 0.0209 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Brugia malayi calpain 5 0.0141 0.0697 0.0795
Brugia malayi EF hand family protein 0.0034 0.0018 0.0014
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Brugia malayi calpain 5 0.0061 0.0186 0.0208
Toxoplasma gondii preprocathepsin c precursor, putative 0.0046 0.0094 0.0276
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Onchocerca volvulus 0.0148 0.074 0.3866
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0068 0.0229 0.0257
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0132 0.0126
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0132 0.0131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0094 0.0276
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0218 0.1183 0.1355
Plasmodium falciparum serine repeat antigen 8 0.0046 0.0094 0.0648
Leishmania major cathepsin L-like protease 0.0064 0.0209 0.0699
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0202 0.1081 0.1226
Entamoeba histolytica cysteine protease, putative 0.0064 0.0209 0.1641
Echinococcus granulosus cathepsin L 0.0054 0.014 0.0155
Echinococcus multilocularis Myosin regulatory light chain 0.0044 0.008 0.0074
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0046 0.0094 0.0108
Trypanosoma cruzi cysteine protease, putative 0.0054 0.014 0.0141
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0202 0.1081 0.3888
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Plasmodium vivax serine-repeat antigen (SERA) 0.0046 0.0094 0.0648
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.014 0.0447
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0217 0.025
Trypanosoma brucei centrin-3 0.0078 0.0297 0.1019
Trichomonas vaginalis caltractin, putative 0.0044 0.008 0.0227
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0046 0.0094 0.0648
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0034 0.0018 0.0014
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.0044 0.008 0.0419
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0132 0.0145
Brugia malayi cathepsin L-like precursor 0.0057 0.0162 0.018
Echinococcus granulosus calcyphosin protein 0.0044 0.008 0.0086
Onchocerca volvulus 0.0109 0.0495 0.2586
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0209 0.022
Entamoeba histolytica hypothetical protein 0.0073 0.0264 0.2108
Echinococcus multilocularis calpain 5 0.0202 0.1081 0.1076
Trypanosoma cruzi centrin, putative 0.0078 0.0297 0.0321
Onchocerca volvulus 0.0044 0.008 0.0419
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0188 0.0993 0.1136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0094 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0218 0.1183 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0194
Plasmodium falciparum serine repeat antigen 6 0.0046 0.0094 0.0648
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0035 0.0021 0.0026
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0209 0.0699
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0202 0.1081 0.3888
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0046 0.0094 0.0108
Schistosoma mansoni calmodulin 0.0034 0.0018 0.0014
Brugia malayi cathepsin L-like cysteine proteinase 0.0046 0.0094 0.0101
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0218 0.1183 0.1343
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0046 0.0094 0.0648
Loa Loa (eye worm) ctsf protein 0.0064 0.0209 0.0241
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0046 0.0094 0.0648
Giardia lamblia Hypothetical protein 0.0046 0.0094 0.0276
Trichomonas vaginalis esterase, putative 0.0109 0.0495 0.1744
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0202 0.1081 0.3888
Echinococcus multilocularis fk506 binding protein 0.0218 0.1183 0.1178
Trypanosoma brucei kinesin, putative 0.0141 0.0697 0.2481
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0186 0.0194
Trypanosoma brucei hypothetical protein 0.0061 0.0186 0.0615
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0068 0.0229 0.0257
Plasmodium falciparum serine repeat antigen 3 0.0046 0.0094 0.0648
Loa Loa (eye worm) hypothetical protein 0.0046 0.0094 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Trypanosoma brucei calpain-like protein, putative 0.0202 0.1081 0.3888
Loa Loa (eye worm) hypothetical protein 0.0394 0.2299 0.2645
Brugia malayi Cathepsin L-like precursor 0.0064 0.0209 0.0234
Echinococcus multilocularis calpain 0.0202 0.1081 0.1076
Loa Loa (eye worm) hypothetical protein 0.0213 0.1154 0.1328
Echinococcus granulosus EF HAND 1 calcium binding site 0.0034 0.0018 0.0014
Echinococcus granulosus Myosin regulatory light chain 0.0044 0.008 0.0086
Schistosoma mansoni rab 0.0034 0.0018 0.0014
Giardia lamblia Cathepsin B precursor 0.0046 0.0094 0.0276
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0079 0.0084
Loa Loa (eye worm) hypothetical protein 0.0032 0.0006 0.0007
Plasmodium falciparum centrin-4 0.0044 0.008 0.0534
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Loa Loa (eye worm) calpain 0.0202 0.1081 0.1244
Echinococcus granulosus EF hand domain containing family member A2 0.0034 0.0018 0.0014
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Loa Loa (eye worm) FKBP5 protein 0.0218 0.1183 0.1361
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0495 0.1744
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0061 0.0186 0.0194
Brugia malayi calpain 7 0.0202 0.1081 0.1238
Echinococcus granulosus neuropeptide s receptor 0.0493 0.2925 0.3361
Loa Loa (eye worm) beta-lactamase 0.0109 0.0495 0.057
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0064 0.0209 0.0203
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0064 0.0209 0.1641
Loa Loa (eye worm) hypothetical protein 0.0046 0.0094 0.0108
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0061 0.0186 0.0194
Echinococcus granulosus neuropeptide receptor A26 0.0493 0.2925 0.3361
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.0725 0.0828
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0218 0.1183 0.1343
Echinococcus granulosus neuronal calcium sensor 0.0034 0.0018 0.0014
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0046 0.0094 0.0648
Schistosoma mansoni mitochondrial solute carrier 0.0034 0.0018 0.0014
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Loa Loa (eye worm) hypothetical protein 0.0064 0.0209 0.0241
Giardia lamblia Programmed cell death protein-like protein 0.0044 0.008 0.0227
Schistosoma mansoni hypothetical protein 0.0034 0.0018 0.0014
Echinococcus multilocularis centrin 2 0.0034 0.0018 0.0012
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0046 0.0094 0.0276
Schistosoma mansoni hypothetical protein 0.0526 0.3136 0.3603
Brugia malayi latrophilin 2 splice variant baaae 0.0146 0.0726 0.0829
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.057 0.3411 0.392
Trichomonas vaginalis calpain, putative 0.0061 0.0186 0.0615
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0034 0.0018 0.0012
Giardia lamblia Cathepsin L precursor 0.0046 0.0094 0.0276
Giardia lamblia Cathepsin B precursor 0.0466 0.2753 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0098 0.0106
Loa Loa (eye worm) hypothetical protein 0.0109 0.0495 0.057
Plasmodium vivax calpain, putative 0.0202 0.1081 0.9127
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0092
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0132 0.0416
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0098 0.0113
Trypanosoma cruzi major cysteine proteinase, putative 0.0046 0.0094 0.0087
Trichomonas vaginalis hypothetical protein 0.0061 0.0186 0.0615
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.0458 0.052
Entamoeba histolytica hypothetical protein 0.0073 0.0264 0.2108
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Schistosoma mansoni chromobox protein 0.0071 0.0253 0.0285
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0218 0.1183 0.426
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0132 0.0416
Trypanosoma brucei calpain, putative 0.0061 0.0186 0.0615
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0194
Loa Loa (eye worm) hypothetical protein 0.004 0.0055 0.0063
Giardia lamblia Cathepsin B precursor 0.0046 0.0094 0.0276
Schistosoma mansoni reticulocalbin 0.0034 0.0018 0.0014
Entamoeba histolytica hypothetical protein 0.0073 0.0264 0.2108
Schistosoma mansoni calpain (C02 family) 0.0202 0.1081 0.1238
Echinococcus multilocularis EF hand domain containing family member A2 0.0034 0.0018 0.0012
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0132 0.0416
Trypanosoma cruzi kinesin, putative 0.0141 0.0697 0.0782
Echinococcus multilocularis calpain A 0.057 0.3411 0.3407
Echinococcus granulosus calpain A 0.057 0.3411 0.392
Trypanosoma cruzi conserved protein 0.0061 0.0186 0.0194
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0132 0.0416
Loa Loa (eye worm) hypothetical protein 0.0109 0.0495 0.057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Trichomonas vaginalis calcium binding protein, putative 0.0078 0.0297 0.1019
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0218 0.1183 0.1361
Brugia malayi Cathepsin L-like precursor 0.0064 0.0209 0.0234
Trichomonas vaginalis kakapo, putative 0.0044 0.008 0.0227
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0495 0.0563
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0094 0.0276
Echinococcus granulosus programmed cell death protein 0.0078 0.0297 0.0335
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0218 0.1183 0.1355
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0132 0.0416
Plasmodium falciparum serine repeat antigen 1 0.0046 0.0094 0.0648
Schistosoma mansoni calpain-7 (C02 family) 0.0202 0.1081 0.1238
Toxoplasma gondii calcium-dependent protein kinase 0.0035 0.0021 0.0011
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0202 0.1081 0.1226
Trichomonas vaginalis immunophilin, putative 0.0218 0.1183 0.426
Entamoeba histolytica cysteine proteinase, putative 0.0064 0.0209 0.1641
Plasmodium falciparum cysteine proteinase falcipain 3 0.0064 0.0209 0.1641
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0194
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0046 0.0094 0.0648
Brugia malayi Cathepsin L-like precursor 0.0064 0.0209 0.0234
Plasmodium vivax vivapain-2 0.0064 0.0209 0.1641
Entamoeba histolytica hypothetical protein 0.0073 0.0264 0.2108
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0217 0.0244
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0218 0.1183 0.426
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0064 0.0209 0.0241
Brugia malayi Calmodulin-like protein 0.0034 0.0018 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.008 0.0072
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1403 0.8691 1
Leishmania major hypothetical protein, conserved 0.0109 0.0495 0.1744
Loa Loa (eye worm) hypothetical protein 0.0034 0.0018 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0217 0.0244
Trypanosoma brucei cysteine peptidase C (CPC) 0.0466 0.2753 1
Mycobacterium leprae conserved hypothetical protein 0.0109 0.0495 0.5
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.0044 0.008 0.0227
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0034 0.0018 0.0012
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.014 0.0141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0209 0.0699
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Giardia lamblia Cathepsin B precursor 0.0046 0.0094 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0094 0.0276
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0074 0.0386
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0074 0.0204
Brugia malayi calcium-binding protein 0.0034 0.0018 0.0014
Giardia lamblia Cathepsin B precursor 0.0466 0.2753 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0186 0.0194
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0495 0.055
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0218 0.1183 1
Leishmania major kinesin, putative 0.0141 0.0697 0.2481
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0046 0.0094 0.0648
Brugia malayi CHE-14 protein 0.0044 0.0079 0.0084
Schistosoma mansoni patched 1 0.0044 0.0079 0.0084
Entamoeba histolytica cysteine proteinase, putative 0.0057 0.0162 0.1238
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0218 0.1183 0.426
Loa Loa (eye worm) hypothetical protein 0.0109 0.0495 0.057
Giardia lamblia Encystation-specific protease 0.0046 0.0094 0.0276
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Brugia malayi cathepsin F-like cysteine proteinase 0.0046 0.0094 0.0101
Trichomonas vaginalis centrin, putative 0.0044 0.008 0.0227
Trichomonas vaginalis calcium binding protein, putative 0.0044 0.008 0.0227
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.014 0.0447
Schistosoma mansoni ef hand domain family member A2 0.0034 0.0018 0.0014
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0202 0.1081 0.1226
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0098 0.0106
Schistosoma mansoni hypothetical protein 0.0068 0.0229 0.0257
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0699 0.4232 1
Brugia malayi Probable myosin regulatory light chain 0.0044 0.008 0.0086
Schistosoma mansoni myosin light chain 0.0044 0.008 0.0086
Echinococcus multilocularis programmed cell death protein 0.0078 0.0297 0.0291
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0495 0.0563
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0186 0.0615
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.014 0.0155
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0035 0.0021 0.0011
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0202 0.1081 0.1226
Echinococcus granulosus cathepsin l1 0.0057 0.0162 0.018
Leishmania major protein kinase, putative 0.0035 0.0021 0.0011
Onchocerca volvulus 0.0064 0.0209 0.1093
Echinococcus multilocularis programmed cell death protein 6 0.0044 0.008 0.0074
Schistosoma mansoni reticulocalbin 0.0034 0.0018 0.0014
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.0094 0.0101
Echinococcus multilocularis calbindin 32 0.0034 0.0018 0.0012
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0202 0.1081 0.1226
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0132 0.0145
Schistosoma mansoni calpain-7 (C02 family) 0.0202 0.1081 0.1238
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0006 0.0007
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.0725 0.072
Echinococcus granulosus cysteine protease 0.0054 0.014 0.0155
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0209 0.022
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0035 0.0021 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0061 0.0186 0.0194
Leishmania major hypothetical protein, conserved 0.0061 0.0186 0.0615
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0466 0.2753 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0098 0.0092
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Onchocerca volvulus 0.0032 0.0006 0.0031
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0202 0.1081 0.1226
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0046 0.0094 0.0648
Loa Loa (eye worm) hypothetical protein 0.0057 0.0162 0.0187
Echinococcus multilocularis GPCR, family 2 0.0068 0.0229 0.0224
Plasmodium vivax vivapain-1 0.0054 0.014 0.105
Onchocerca volvulus 0.0046 0.0094 0.0489
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0132 0.0416
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0218 0.1183 0.1355
Echinococcus multilocularis neuropeptide s receptor 0.0493 0.2925 0.2921
Plasmodium falciparum serine repeat antigen 2 0.0046 0.0094 0.0648
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.0495 0.0563
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0098 0.0092
Schistosoma mansoni hypothetical protein 0.0068 0.0229 0.0257
Echinococcus granulosus centrin 2 0.0034 0.0018 0.0014
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0046 0.0094 0.0108
Schistosoma mansoni immunophilin 0.0188 0.0993 0.1136
Echinococcus granulosus cathepsin b 0.1403 0.8691 1
Trypanosoma brucei calpain, putative 0.0061 0.0186 0.0615
Schistosoma mansoni cathepsin C 0.0046 0.0094 0.0101
Brugia malayi Latrophilin receptor protein 2 0.0068 0.0229 0.0257
Plasmodium falciparum serine repeat antigen 9 0.0046 0.0094 0.0648
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0209 0.022
Entamoeba histolytica hypothetical protein 0.0046 0.0094 0.0648
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0061 0.0186 0.0615
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Loa Loa (eye worm) hypothetical protein 0.0146 0.0726 0.0835
Loa Loa (eye worm) latrophilin receptor protein 2 0.0068 0.0229 0.0264
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0448 0.0442
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0074 0.0204
Trypanosoma cruzi cysteine proteinase, putative 0.0054 0.014 0.0141
Loa Loa (eye worm) EF hand family protein 0.0034 0.0018 0.0021
Toxoplasma gondii calmodulin, putative 0.0044 0.008 0.0227
Entamoeba histolytica calmodulin, putative 0.0044 0.008 0.0534
Entamoeba histolytica cysteine protease, putative 0.0046 0.0094 0.0648
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0055 0.0286
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0061 0.0186 0.0615
Leishmania major calpain protease-like protein 0.0061 0.0186 0.0615
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Giardia lamblia Cysteine protease 0.0046 0.0094 0.0276
Schistosoma mansoni calmodulin related calcium binding protein 0.0034 0.0018 0.0014
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0218 0.1183 0.1343
Brugia malayi cathepsin Z-like cysteine proteinase 0.0046 0.0094 0.0101
Echinococcus multilocularis cathepsin b 0.1403 0.8691 0.8691
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0079 0.0222
Brugia malayi RNA binding protein 0.0066 0.0217 0.0244
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0054 0.014 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0064 0.0209 0.0699
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0055 0.0134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Mycobacterium leprae Probable lipase LipE 0.0109 0.0495 0.5
Echinococcus granulosus expressed conserved protein 0.0096 0.0409 0.0464
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0046 0.0094 0.0648
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0218 0.1183 0.1355
Entamoeba histolytica grainin 2 0.0078 0.0297 0.2393
Echinococcus multilocularis programmed cell death protein 0.0078 0.0297 0.0291
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0046 0.0094 0.0101
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0209 0.0699
Echinococcus granulosus chromobox protein 1 0.0071 0.0253 0.0285
Brugia malayi Myosin regulatory light chain 1 0.0044 0.008 0.0086
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0194
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0186 0.0615
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0046 0.0094 0.0276
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Echinococcus multilocularis chromobox protein 1 0.0071 0.0253 0.0247
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.014 0.0155
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0209 0.0699
Schistosoma mansoni hypothetical protein 0.0034 0.0018 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0094 0.0276
Echinococcus granulosus calcium uptake protein 1 0.0034 0.0018 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.014 0.0447
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0202 0.1081 0.1226
Plasmodium falciparum serine repeat antigen 4 0.0046 0.0094 0.0648
Brugia malayi EF hand family protein 0.0034 0.0018 0.0014
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0054 0.014 0.0141
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0098 0.0106
Brugia malayi calpain D 0.0061 0.0186 0.0208
Loa Loa (eye worm) calpain family protein 1 0.0536 0.3194 0.3675
Loa Loa (eye worm) hypothetical protein 0.0044 0.0079 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0186 0.0194
Trypanosoma brucei Calpain-like protein 2 0.0061 0.0186 0.0615
Onchocerca volvulus 0.0034 0.0018 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0046 0.0094 0.0276
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0064 0.0209 0.0241
Onchocerca volvulus 0.0109 0.0495 0.2586
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0046 0.0094 0.0276
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Echinococcus granulosus cathepsin b 0.1403 0.8691 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0218 0.1183 0.1178
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0194
Giardia lamblia Cathepsin B precursor 0.0466 0.2753 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0046 0.0094 0.0648
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0094 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Entamoeba histolytica cysteine protease, putative 0.0046 0.0094 0.0648
Brugia malayi cathepsin B-like cysteine proteinase 0.1403 0.8691 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0094 0.0276
Brugia malayi hypothetical protein 0.0073 0.0264 0.0297
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0253 0.086
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0132 0.0126
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1403 0.8691 1
Trypanosoma brucei cysteine peptidase, putative 0.0061 0.0186 0.0615
Trichomonas vaginalis calpain, putative 0.0061 0.0186 0.0615
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Echinococcus multilocularis neuropeptide receptor A26 0.0493 0.2925 0.2921
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Loa Loa (eye worm) hypothetical protein 0.0061 0.0186 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Trypanosoma brucei protein kinase, putative 0.0052 0.0132 0.0416
Echinococcus multilocularis cysteine protease 0.0064 0.0209 0.0203
Echinococcus granulosus EF hand domain containing family member A2 0.0034 0.0018 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Echinococcus granulosus cathepsin l cysteine peptidase 0.0064 0.0209 0.0234
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0209 0.022
Loa Loa (eye worm) hypothetical protein 0.0057 0.0162 0.0187
Plasmodium vivax serine-repeat antigen (SERA) 0.0046 0.0094 0.0648
Echinococcus granulosus calpain 0.0202 0.1081 0.1238
Brugia malayi Papain family cysteine protease containing protein 0.0064 0.0209 0.0234
Brugia malayi Cathepsin L-like precursor 0.0064 0.0209 0.0234
Leishmania major cathepsin L-like protease 0.0064 0.0209 0.0699
Brugia malayi TAR-binding protein 0.0066 0.0217 0.0244
Brugia malayi Calcitonin receptor-like protein seb-1 0.0213 0.1154 0.1322
Loa Loa (eye worm) hypothetical protein 0.0046 0.0094 0.0108
Trichomonas vaginalis centrin, putative 0.0044 0.008 0.0227
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0495 0.1744
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0186 0.0194
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Toxoplasma gondii centrin family protein 0.0044 0.008 0.0227
Loa Loa (eye worm) hypothetical protein 0.0536 0.3194 0.3675
Toxoplasma gondii cathepsin B 0.0466 0.2753 1
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0061 0.0186 0.0194
Onchocerca volvulus 0.0044 0.008 0.0419
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0094 0.0276
Trypanosoma cruzi centrin-3 0.0078 0.0297 0.0321
Schistosoma mansoni hypothetical protein 0.0526 0.3136 0.3603
Plasmodium falciparum cysteine proteinase falcipain 1 0.0054 0.014 0.105
Brugia malayi Neuronal calcium sensor family protein 1 0.0044 0.008 0.0086
Schistosoma mansoni hypothetical protein 0.0068 0.0229 0.0257
Echinococcus granulosus programmed cell death protein 6 0.0044 0.008 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Loa Loa (eye worm) hypothetical protein 0.1403 0.8691 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0054 0.014 0.0155
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0218 0.1183 0.1355
Onchocerca volvulus 0.0334 0.1915 1
Loa Loa (eye worm) RNA binding protein 0.0066 0.0217 0.025
Leishmania major cathepsin L-like protease 0.0064 0.0209 0.0699
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0218 0.1183 1
Entamoeba histolytica cysteine protease, putative 0.0046 0.0094 0.0648
Schistosoma mansoni centrin-related 0.0034 0.0018 0.0014
Giardia lamblia Cathepsin L precursor 0.0046 0.0094 0.0276
Loa Loa (eye worm) cysteine protease 0.0064 0.0209 0.0241
Toxoplasma gondii EF hand domain-containing protein 0.0044 0.008 0.0227
Entamoeba histolytica cysteine protease, putative 0.0046 0.0094 0.0648
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0046 0.0094 0.0276
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0217 0.0244
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Plasmodium vivax vivapain-2 0.0064 0.0209 0.1641
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0218 0.1183 0.426
Onchocerca volvulus 0.0109 0.0495 0.2586
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0098 0.0106
Entamoeba histolytica protein kinase, putative 0.0142 0.07 0.585
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0264 0.0297
Loa Loa (eye worm) hypothetical protein 0.0032 0.0002 0.0003
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0034 0.0018 0.0014
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0536 0.3194 0.3671
Brugia malayi beta-lactamase 0.0109 0.0495 0.0563
Leishmania major cysteine peptidase A (CPA) 0.0064 0.0209 0.0699
Giardia lamblia Cathepsin B precursor 0.0046 0.0094 0.0276
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.014 0.0447
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0202 0.1081 0.1226
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.014 0.105
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0218 0.1183 0.426
Loa Loa (eye worm) hypothetical protein 0.0102 0.0448 0.0515
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0202 0.1081 0.3888
Giardia lamblia Cathepsin B precursor 0.0046 0.0094 0.0276
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0495 0.1744
Giardia lamblia Cysteine protease 0.0046 0.0094 0.0276
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0061 0.0186 0.0615
Echinococcus multilocularis neuronal calcium sensor 0.0034 0.0018 0.0012
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0046 0.0094 0.0101
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0098 0.0106
Schistosoma mansoni immunophilin 0.0218 0.1183 0.1355
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0466 0.2753 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0186 0.0194
Trichomonas vaginalis calpain, putative 0.0061 0.0186 0.0615
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0202 0.1081 0.3888
Onchocerca volvulus Cathepsin F homolog 0.0064 0.0209 0.1093
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Schistosoma mansoni hypothetical protein 0.0042 0.0069 0.0072
Giardia lamblia Cathepsin L precursor 0.0046 0.0094 0.0276
Leishmania major hypothetical protein, unknown function 0.0061 0.0186 0.0615
Brugia malayi Cathepsin L-like precursor 0.0057 0.0162 0.018
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0202 0.1081 0.1226
Trypanosoma brucei Calpain-like protein CALP1.3 0.0061 0.0186 0.0615
Onchocerca volvulus Cathepsin L homolog 0.0046 0.0094 0.0489
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0079 0.0084
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0034 0.0018 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0217 0.0244
Schistosoma mansoni hypothetical protein 0.0073 0.0264 0.0297
Echinococcus granulosus cathepsin L cysteine protease 0.0054 0.014 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0094 0.0276
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.0495 0.0563
Echinococcus multilocularis calcyphosin protein 0.0044 0.008 0.0074
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0044 0.008 0.0419
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1403 0.8691 1
Trypanosoma brucei calpain-like protein, putative 0.0202 0.1081 0.3888
Toxoplasma gondii hypothetical protein 0.0061 0.0186 0.0615
Echinococcus multilocularis chromobox protein 1 0.0071 0.0253 0.0247
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0064 0.0209 0.0203
Echinococcus granulosus geminin 0.0526 0.3136 0.3603
Echinococcus multilocularis protein patched 0.0044 0.0079 0.0073
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0035 0.0021 0.0003
Schistosoma mansoni hypothetical protein 0.0042 0.0069 0.0072
Brugia malayi Heterochromatin protein 1 0.0071 0.0253 0.0285
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0218 0.1183 1
Echinococcus multilocularis EF hand domain containing family member A2 0.0034 0.0018 0.0012
Leishmania major calpain family cysteine protease-like protein 0.0061 0.0186 0.0615
Trichomonas vaginalis calmodulin, putative 0.0044 0.008 0.0227
Onchocerca volvulus Cathepsin L homolog 0.0064 0.0209 0.1093
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0079 0.0091
Loa Loa (eye worm) calpain 5 0.0141 0.0697 0.0801
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.057 0.3411 0.3407
Schistosoma mansoni chromobox protein 0.0071 0.0253 0.0285
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0253 0.086
Trypanosoma brucei caltractin, putative 0.0078 0.0297 0.1019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0094 0.0276
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0186 0.0615
Echinococcus multilocularis calmodulin 0.0034 0.0018 0.0012
Plasmodium falciparum calpain 0.0061 0.0186 0.1443
Loa Loa (eye worm) hypothetical protein 0.0057 0.0162 0.0187
Echinococcus multilocularis expressed conserved protein 0.0096 0.0409 0.0403
Leishmania major cathepsin L-like protease 0.0064 0.0209 0.0699
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0068 0.0229 0.0224
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0466 0.2753 0.3153
Giardia lamblia Cathepsin L precursor 0.0046 0.0094 0.0276
Loa Loa (eye worm) cathepsin B 0.0466 0.2753 0.3167
Loa Loa (eye worm) hypothetical protein 0.0109 0.0495 0.057
Loa Loa (eye worm) calmodulin-like protein 0.0034 0.0018 0.0021
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0194
Plasmodium vivax vivapain-3 0.0054 0.014 0.105
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0046 0.0094 0.0648
Brugia malayi Cathepsin L-like precursor 0.0057 0.0162 0.018
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.0495 0.057
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0046 0.0094 0.0648
Trypanosoma cruzi kinesin, putative 0.0141 0.0697 0.0782
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0162 0.0527
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0132 0.0145
Schistosoma mansoni hypothetical protein 0.0146 0.0726 0.0829
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0264 0.0258
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0194
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0495 0.4094
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0253 0.0291
Brugia malayi hypothetical protein 0.0148 0.074 0.0845
Schistosoma mansoni immunophilin 0.0218 0.1183 0.1355
Plasmodium vivax myosin A tail domain interacting protein MTIP, putative 0.0044 0.008 0.0534
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0046 0.0094 0.0648
Schistosoma mansoni neuronal calcium sensor 0.0034 0.0018 0.0014
Toxoplasma gondii cathepsin CPL 0.0064 0.0209 0.0699
Entamoeba histolytica cysteine proteinase 2 0.0054 0.014 0.105
Echinococcus multilocularis protein dispatched 1 0.005 0.0118 0.0112
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.014 0.105
Onchocerca volvulus 0.0064 0.0209 0.1093
Brugia malayi programmed cell death protein 6 0.0034 0.0018 0.0014
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0495 0.1744
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0046 0.0094 0.0101
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0094 0.0101
Leishmania major peptidylprolyl isomerase-like protein 0.0218 0.1183 0.426
Schistosoma mansoni calmodulin 0.0034 0.0018 0.0014
Brugia malayi Cathepsin L-like precursor 0.0064 0.0209 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0094 0.0276
Trichomonas vaginalis fk506-binding protein, putative 0.0218 0.1183 0.426
Trypanosoma cruzi centrin, putative 0.0078 0.0297 0.0321
Echinococcus multilocularis calpain 7 (C02 family) 0.0202 0.1081 0.1076
Brugia malayi beta-lactamase family protein 0.0109 0.0495 0.0563
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0495 0.1744
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0094 0.0101
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0092
Loa Loa (eye worm) hypothetical protein 0.0034 0.0018 0.0021
Echinococcus granulosus chromobox protein 1 0.0071 0.0253 0.0285
Schistosoma mansoni myosin regulatory light chain 0.0044 0.008 0.0086
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.057 0.3411 0.392
Echinococcus granulosus calbindin 32 0.0034 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0188 0.0993 0.1142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Echinococcus granulosus calpain 7 C02 family 0.0202 0.1081 0.1238
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0094 0.0101
Loa Loa (eye worm) hypothetical protein 0.0046 0.0094 0.0108
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0046 0.0094 0.0276
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0194
Loa Loa (eye worm) calpain D 0.0061 0.0186 0.0214
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0132 0.0416
Schistosoma mansoni neuronal calcium sensor 0.0034 0.0018 0.0014
Giardia lamblia Cathepsin L precursor 0.0046 0.0094 0.0276
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0132 0.0152
Loa Loa (eye worm) hypothetical protein 0.0109 0.0495 0.057
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0213 0.1154 0.1322
Toxoplasma gondii cathepsin CPC1 0.0046 0.0094 0.0276
Brugia malayi calpain family protein 1 0.0536 0.3194 0.3671
Schistosoma mansoni calpain C (C02 family) 0.0202 0.1081 0.1238
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Echinococcus granulosus tar DNA binding protein 0.0066 0.0217 0.0244
Echinococcus granulosus calmodulin 0.0034 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0334 0.1915 0.2203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Entamoeba histolytica grainin 2 0.0044 0.008 0.0534
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0079 0.0073
Schistosoma mansoni cathepsin F (C01 family) 0.0057 0.0162 0.018
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0068 0.0229 0.0257
Giardia lamblia Hypothetical protein 0.0046 0.0094 0.0276
Echinococcus multilocularis cathepsin L 0.0054 0.014 0.0135
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1403 0.8691 1
Leishmania major cathepsin L-like protease 0.0064 0.0209 0.0699
Brugia malayi chromobox protein homolog 3 0.004 0.0055 0.0056
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0202 0.1081 0.1226
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0046 0.0094 0.0276
Loa Loa (eye worm) calpain family protein 1 0.0394 0.2299 0.2645
Onchocerca volvulus 0.0034 0.0018 0.0095
Schistosoma mansoni cathepsin F (C01 family) 0.0064 0.0209 0.0234
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.014 0.105
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0046 0.0094 0.0648
Echinococcus granulosus calumenin 0.0034 0.0018 0.0014
Echinococcus multilocularis neurocalcin 0.0034 0.0018 0.0012
Leishmania major cathepsin L-like protease 0.0064 0.0209 0.0699
Toxoplasma gondii cathepsin CPC2 0.0046 0.0094 0.0276
Loa Loa (eye worm) hypothetical protein 0.0148 0.074 0.0852
Echinococcus granulosus cathepsin L 0.0046 0.0094 0.0101
Brugia malayi MAP kinase sur-1 0.0052 0.0132 0.0145
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0448 0.369
Trypanosoma brucei antigen, putative 0.0202 0.1081 0.3888
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0217 0.0244
Loa Loa (eye worm) myosin Light Chain family member 0.0044 0.008 0.0092
Brugia malayi cathepsin Z-like cysteine proteinase 0.0046 0.0094 0.0101
Trypanosoma brucei Calpain-like protein 1.1 0.0061 0.0186 0.0615
Onchocerca volvulus 0.0064 0.0209 0.1093
Trypanosoma brucei calpain-like protein, putative 0.0202 0.1081 0.3888
Loa Loa (eye worm) hypothetical protein 0.0046 0.0094 0.0108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0209 0.0699
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Entamoeba histolytica cysteine proteinase, putative 0.0064 0.0209 0.1641
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0495 0.055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0094 0.0276
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.0094 0.0101
Entamoeba histolytica calpain large subunit domain III containing protein 0.0141 0.0697 0.5824
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Loa Loa (eye worm) hypothetical protein 0.0054 0.0141 0.0163
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0132 0.0131
Onchocerca volvulus Cathepsin L homolog 0.0064 0.0209 0.1093
Brugia malayi cathepsin L precursor 0.0046 0.0094 0.0101
Echinococcus granulosus calpain 5 0.0202 0.1081 0.1238
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0186 0.0615
Giardia lamblia Cysteine protease 0.0046 0.0094 0.0276
Brugia malayi Cathepsin L-like cysteine proteinase 0.0057 0.0162 0.018
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0162 0.0166
Toxoplasma gondii ABC1 family protein 0.0109 0.0495 0.1744
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0186 0.0615
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0132 0.0131
Echinococcus multilocularis cysteine protease 0.0064 0.0209 0.0203
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.0094 0.0101
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0092
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0186 0.0194
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0448 0.0509
Echinococcus granulosus cathepsin L cysteine proteinase 0.0064 0.0209 0.0234
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0209 0.0699
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0218 0.1183 0.426
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0209 0.0699
Onchocerca volvulus 0.0032 0.0006 0.0031
Loa Loa (eye worm) hypothetical protein 0.0109 0.0495 0.057
Schistosoma mansoni neuronal calcium sensor 0.0034 0.0018 0.0014
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0218 0.1183 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0046 0.0094 0.0648
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0264 0.0297
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0064 0.0209 0.1641
Entamoeba histolytica calpain family cysteine protease, putative 0.0061 0.0186 0.1443
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0186 0.0615
Onchocerca volvulus 0.0064 0.0209 0.1093
Giardia lamblia Cathepsin L-like protease 0.0046 0.0094 0.0276
Echinococcus granulosus neurocalcin 0.0034 0.0018 0.0014
Schistosoma mansoni hypothetical protein 0.0042 0.0069 0.0072
Schistosoma mansoni calpain-2 (C02 family) 0.0061 0.0186 0.0208
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0162 0.0527
Loa Loa (eye worm) myosin regulatory light chain 1 0.0044 0.008 0.0092
Trichomonas vaginalis calmodulin, putative 0.0078 0.0297 0.1019
Plasmodium vivax unspecified product 0.0054 0.014 0.105
Entamoeba histolytica cysteine protease, putative 0.0054 0.014 0.105
Brugia malayi RasGEF domain containing protein 0.0044 0.008 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0046 0.0094 0.0276
Echinococcus granulosus Calcium binding protein 0.0044 0.008 0.0086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0209 0.0699
Toxoplasma gondii calcium binding protein precursor, putative 0.0044 0.008 0.0227
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0186 0.0615
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0006 0.0007
Plasmodium falciparum serine repeat antigen 7 0.0046 0.0094 0.0648
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0054 0.014 0.0155
Schistosoma mansoni centrin 0.0034 0.0018 0.0014
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0046 0.0094 0.0101
Loa Loa (eye worm) hypothetical protein 0.0068 0.0229 0.0264
Plasmodium vivax unspecified product 0.0046 0.0094 0.0648
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0188 0.0993 0.0988
Schistosoma mansoni Mername-AA248 (C02 family) 0.0202 0.1081 0.1238
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0448 0.0509
Schistosoma mansoni cathepsin F (C01 family) 0.0064 0.0209 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0055 0.0134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0209 0.0699
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0094 0.0276
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0046 0.0094 0.0648
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.057 0.3411 0.392
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.014 0.105
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0186 0.0615
Trypanosoma brucei calpain-like protein, putative 0.0202 0.1081 0.3888
Brugia malayi fibroinase precursor 0.0046 0.0094 0.0101
Entamoeba histolytica cysteine protease, putative 0.0046 0.0094 0.0648
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Brugia malayi beta-lactamase family protein 0.0109 0.0495 0.0563
Onchocerca volvulus 0.0034 0.0018 0.0095
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0213 0.1154 0.1328
Schistosoma mansoni hypothetical protein 0.0042 0.0069 0.0072
Loa Loa (eye worm) fibroinase 0.0064 0.0209 0.0241
Toxoplasma gondii calmodulin CAM2 0.0044 0.008 0.0227
Trypanosoma cruzi major cysteine proteinase, putative 0.0046 0.0094 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0217 0.0244
Echinococcus multilocularis cathepsin L 0.0046 0.0094 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0094 0.0276
Echinococcus multilocularis calmodulin 0.0034 0.0018 0.0012
Schistosoma mansoni neuronal calcium sensor 0.0034 0.0018 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0132 0.0416
Echinococcus granulosus GPCR family 2 0.0068 0.0229 0.0257
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0068 0.0229 0.0224
Schistosoma mansoni myosin regulatory light chain 0.0044 0.008 0.0086
Entamoeba histolytica cysteine protease, putative 0.0046 0.0094 0.0648
Loa Loa (eye worm) hypothetical protein 0.0475 0.281 0.3233
Onchocerca volvulus 0.0064 0.0209 0.1093
Giardia lamblia Cysteine protease 0.0046 0.0094 0.0276
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0217 0.0212
Loa Loa (eye worm) hypothetical protein 0.0046 0.0094 0.0108
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0094 0.0101
Giardia lamblia Cathepsin L precursor 0.0046 0.0094 0.0276
Onchocerca volvulus 0.0064 0.0209 0.1093
Brugia malayi calpain family protein 1 0.0536 0.3194 0.3671
Onchocerca volvulus 0.0064 0.0209 0.1093
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.0495 0.0489
Leishmania major fk506-binding protein 1-like protein 0.0218 0.1183 0.426
Echinococcus multilocularis geminin 0.0526 0.3136 0.3131
Echinococcus multilocularis cathepsin b 0.1403 0.8691 0.8691
Echinococcus multilocularis hypothetical protein 0.0202 0.1081 0.1076
Echinococcus multilocularis calumenin 0.0034 0.0018 0.0012
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0132 0.0416
Echinococcus multilocularis cathepsin L cysteine protease 0.0064 0.0209 0.0203
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0098 0.0106
Echinococcus multilocularis calpain family protein 1, d 0.0394 0.2299 0.2295
Giardia lamblia Cathepsin L-like protease 0.0046 0.0094 0.0276
Schistosoma mansoni hypothetical protein 0.0061 0.0186 0.0208
Leishmania major cathepsin L-like protease 0.0064 0.0209 0.0699
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0046 0.0094 0.0276
Onchocerca volvulus 0.0057 0.0162 0.0848
Leishmania major cathepsin L-like protease 0.0064 0.0209 0.0699
Schistosoma mansoni cathepsin B (C01 family) 0.0046 0.0094 0.0101
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0466 0.2753 0.3162
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0064 0.0209 0.0699
Trypanosoma brucei Calpain-like protein 1.2 0.0061 0.0186 0.0615
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0132 0.0131
Echinococcus granulosus calpain A 0.0202 0.1081 0.1238
Schistosoma mansoni calmodulin-related 0.0044 0.008 0.0086
Echinococcus multilocularis cathepsin L cysteine protease 0.0064 0.0209 0.0203
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0218 0.1183 0.1343
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0209 0.0699
Giardia lamblia Calmodulin 0.0044 0.008 0.0227
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0217 0.025
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0218 0.1183 0.5
Trichomonas vaginalis centrin, putative 0.0044 0.008 0.0227
Brugia malayi Cathepsin L-like precursor 0.0064 0.0209 0.0234
Loa Loa (eye worm) programmed cell death protein 6 0.0034 0.0018 0.0021
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0046 0.0094 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.008 0.0227
Schistosoma mansoni cathepsin S (C01 family) 0.0046 0.0094 0.0101
Echinococcus multilocularis Calcium binding protein 0.0044 0.008 0.0074
Schistosoma mansoni hypothetical protein 0.0068 0.0229 0.0257
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0046 0.0094 0.0101
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0209 0.022
Echinococcus multilocularis calcium uptake protein 1 0.0034 0.0018 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0209 0.0699
Plasmodium falciparum serine repeat antigen 5 0.0046 0.0094 0.0648

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 1 % Displacement of [3H]ZM241385 from human recombinant adenosine A2A receptor expressed in CHO cell membranes at 1 uM by scintillation counting ChEMBL. 21616671
Inhibition (binding) = 1 % Displacement of [125I]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells at 1 uM by scintillation counting ChEMBL. 21616671
Inhibition (functional) = 3 % Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP levels at 1 uM ChEMBL. 21616671
Ki (binding) = 455 nM Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in CHO cell membranes by scintillation counting ChEMBL. 21616671

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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