Detailed information for compound 1312040

Basic information

Technical information
  • TDR Targets ID: 1312040
  • Name: MLS000877971
  • MW: 324.443 | Formula: C18H20N4S
  • H donors: 1 H acceptors: 3 LogP: 4.36 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCc2c(C1)sc1c2c(NCc2cccnc2)nc(n1)C
  • InChi: 1S/C18H20N4S/c1-11-5-6-14-15(8-11)23-18-16(14)17(21-12(2)22-18)20-10-13-4-3-7-19-9-13/h3-4,7,9,11H,5-6,8,10H2,1-2H3,(H,20,21,22)
  • InChiKey: HSTAJKAXKSYTCE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • SMR000376882
  • T5292201

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Cysteine protease 0.0034 0.0296 0.0485
Onchocerca volvulus 0.0035 0.0315 0.0751
Loa Loa (eye worm) calmodulin-like protein 0.0026 0.021 0.021
Echinococcus multilocularis calpain 7 (C02 family) 0.0219 0.2497 0.2497
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0043 0.0043
Giardia lamblia Encystation-specific protease 0.0034 0.0296 0.0485
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.073 0.1686
Leishmania major pyruvate kinase 0.004 0.0376 0.0538
Echinococcus granulosus calpain A 0.0607 0.7099 0.7099
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0074
Entamoeba histolytica cysteine protease, putative 0.0034 0.0296 0.0574
Trypanosoma brucei cysteine peptidase C (CPC) 0.0286 0.3297 1
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0123 0.1352 0.1352
Schistosoma mansoni integrin alpha-ps 0.0035 0.0313 0.0313
Loa Loa (eye worm) calpain 0.0219 0.2497 0.2497
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.073 0.1686
Plasmodium falciparum plasmepsin III 0.0035 0.0315 0.1129
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0472 0.0401
Onchocerca volvulus 0.007 0.073 0.1744
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0043 0.0043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.073 0.1686
Schistosoma mansoni pyruvate kinase 0.004 0.0376 0.0376
Giardia lamblia Cathepsin L precursor 0.0034 0.0296 0.0485
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0043 0.0043
Loa Loa (eye worm) integrin alpha pat-2 0.0231 0.2639 0.2639
Echinococcus multilocularis integrin alpha 3 0.0115 0.1261 0.1261
Schistosoma mansoni hypothetical protein 0.0413 0.4804 0.4804
Schistosoma mansoni coup transcription factor 0.0012 0.0043 0.0043
Echinococcus granulosus pyruvate kinase 0.004 0.0376 0.0376
Echinococcus multilocularis Smad4 0.001 0.0014 0.0014
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0296 0.0707
Entamoeba histolytica cysteine proteinase, putative 0.0055 0.0554 0.2288
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0679 0.152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.073 0.1686
Echinococcus multilocularis calpain family protein 1, d 0.0427 0.497 0.497
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0034 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0043
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0085 0.0085
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0085 0.0085
Trypanosoma brucei Calpain-like protein 1.2 0.0066 0.0679 0.152
Echinococcus granulosus EF hand domain containing family member A2 0.0026 0.021 0.021
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0043 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0043 0.0043
Brugia malayi aspartic protease BmAsp-1, identical 0.0035 0.0315 0.0315
Schistosoma mansoni hypothetical protein 0.0016 0.0085 0.0085
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0034 0.0296 0.0296
Echinococcus granulosus pyruvate kinase 0.0021 0.0143 0.0143
Plasmodium vivax centrin-1, putative 0.0026 0.021 0.0561
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0219 0.2497 0.7407
Giardia lamblia Cathepsin B precursor 0.0034 0.0296 0.0485
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0315 0.0315
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0035 0.0315 0.0543
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0219 0.2497 0.2441
Entamoeba histolytica cysteine proteinase, putative 0.007 0.073 0.3457
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0296 0.0296
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0554 0.1116
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.152
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0376 0.0304
Loa Loa (eye worm) hypothetical protein 0.0055 0.0554 0.0554
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.061
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0231 0.2636 0.2636
Brugia malayi calpain 5 0.0153 0.1715 0.1715
Brugia malayi calpain family protein 1 0.0581 0.6787 0.6787
Echinococcus multilocularis calpain A 0.0607 0.7099 0.7099
Giardia lamblia Cathepsin B precursor 0.0034 0.0296 0.0485
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0768 0.1981
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0003 0.0003
Echinococcus granulosus pyruvate kinase 0.0021 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0214 0.2443 0.2443
Onchocerca volvulus Cathepsin L homolog 0.007 0.073 0.1744
Schistosoma mansoni hypothetical protein 0.0016 0.0085 0.0085
Schistosoma mansoni hypothetical protein 0.0032 0.028 0.028
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0026 0.021 0.021
Entamoeba histolytica cysteine protease, putative 0.0048 0.0472 0.1742
Entamoeba histolytica cysteine proteinase, putative 0.0048 0.0472 0.1742
Brugia malayi cathepsin Z-like cysteine proteinase 0.0034 0.0296 0.0296
Entamoeba histolytica cysteine proteinase 1, putative 0.0048 0.0472 0.1742
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.073 0.1686
Toxoplasma gondii centrin, putative 0.0026 0.021 0.0211
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0219 0.2497 0.2441
Trypanosoma brucei Calpain-like protein 1.1 0.0066 0.0679 0.152
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.152
Entamoeba histolytica cysteine proteinase, putative 0.007 0.073 0.3457
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.073 0.1686
Loa Loa (eye worm) hypothetical protein 0.0035 0.0315 0.0315
Entamoeba histolytica cysteine proteinase, putative 0.0048 0.0472 0.1742
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0296 0.0296
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0325 0.0373
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0376 0.0376
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0043 0.0043
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0325 0.0325
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0149 0.1661 0.1661
Entamoeba histolytica cysteine protease, putative 0.007 0.073 0.3457
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0066 0.0679 0.152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.073 0.1686
Trypanosoma cruzi I/6 autoantigen, putative 0.0026 0.021 0.0137
Loa Loa (eye worm) pyruvate kinase 0.004 0.0376 0.0376
Plasmodium falciparum serine repeat antigen 8 0.0034 0.0296 0.1008
Echinococcus multilocularis centrin 2 0.0026 0.021 0.021
Echinococcus granulosus neurocalcin 0.0026 0.021 0.021
Schistosoma mansoni cpg binding protein 0.0031 0.0262 0.0262
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0043 0.0043
Brugia malayi MH2 domain containing protein 0.001 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0026 0.021 0.021
Loa Loa (eye worm) fibroinase 0.007 0.073 0.073
Echinococcus granulosus cathepsin L cysteine proteinase 0.007 0.073 0.073
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0034 0.0296 0.0485
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0035 0.0315 0.0315
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1609 0.1609
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0048 0.0472 0.0472
Loa Loa (eye worm) cysteine protease 0.007 0.073 0.073
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0043 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0472 0.085
Echinococcus granulosus cathepsin L 0.0034 0.0296 0.0296
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0048 0.0472 0.0401
Loa Loa (eye worm) hypothetical protein 0.0113 0.1243 0.1243
Entamoeba histolytica cysteine protease, putative 0.0048 0.0472 0.1742
Echinococcus multilocularis integrin alpha ps 0.0067 0.0695 0.0695
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.152
Brugia malayi EF hand family protein 0.0026 0.021 0.021
Brugia malayi nuclear receptor NHR-88 0.0012 0.0043 0.0043
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0315 0.0315
Echinococcus granulosus cathepsin b 0.0851 1 1
Brugia malayi hypothetical protein 0.0035 0.0315 0.0315
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0409 0.0843
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.073 0.1686
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0034 0.0296 0.1008
Echinococcus multilocularis EF hand domain containing family member A2 0.0026 0.021 0.021
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0325 0.0373
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.152
Trypanosoma cruzi kinesin, putative 0.0153 0.1715 0.1654
Leishmania major hypothetical protein, conserved 0.0066 0.0679 0.152
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0014 0.0014
Giardia lamblia Cathepsin B precursor 0.0034 0.0296 0.0485
Schistosoma mansoni calpain-7 (C02 family) 0.0219 0.2497 0.2497
Brugia malayi cathepsin L precursor 0.0034 0.0296 0.0296
Toxoplasma gondii centrin 0.0026 0.021 0.0211
Loa Loa (eye worm) hypothetical protein 0.0032 0.028 0.028
Echinococcus granulosus cathepsin L 0.0048 0.0472 0.0472
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0074 0.0074
Echinococcus multilocularis calbindin 32 0.0026 0.021 0.021
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0043 0.0102
Echinococcus multilocularis calpain 0.0219 0.2497 0.2497
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0043
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0066 0.0679 0.061
Plasmodium vivax plasmepsin IV, putative 0.0149 0.1661 0.6549
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0286 0.3297 1
Plasmodium falciparum plasmepsin I 0.0149 0.1661 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0296 0.028
Plasmodium vivax serine-repeat antigen (SERA) 0.0034 0.0296 0.0918
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.152
Echinococcus granulosus dnaJ subfamily B 0.0413 0.4804 0.4804
Loa Loa (eye worm) calpain 5 0.0153 0.1715 0.1715
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0376 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.007 0.073 0.1686
Toxoplasma gondii aspartyl protease 0.0035 0.0315 0.0543
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0219 0.2497 0.2441
Schistosoma mansoni pyruvate kinase 0.0021 0.0143 0.0143
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0149 0.1661 0.481
Loa Loa (eye worm) calpain D 0.0066 0.0679 0.0679
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0026 0.021 0.021
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0043 0.0043
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0043 0.0043
Plasmodium falciparum plasmepsin IV 0.0149 0.1661 1
Brugia malayi aspartic protease BmAsp-2, identical 0.0035 0.0315 0.0315
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.152
Entamoeba histolytica cysteine protease, putative 0.0034 0.0296 0.0574
Schistosoma mansoni neuronal calcium sensor 0.0026 0.021 0.021
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0219 0.2497 0.2441
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0491 0.0491
Schistosoma mansoni integrin alpha-ps 0.0067 0.0695 0.0695
Entamoeba histolytica hypothetical protein 0.0034 0.0296 0.0574
Echinococcus multilocularis programmed cell death protein 0.0026 0.021 0.021
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.1636 0.1636
Echinococcus multilocularis cathepsin L cysteine protease 0.007 0.073 0.073
Brugia malayi sulfakinin receptor protein 0.0214 0.2443 0.2443
Trypanosoma cruzi cysteine proteinase, putative 0.0048 0.0472 0.0401
Brugia malayi Cathepsin L-like precursor 0.007 0.073 0.073
Entamoeba histolytica cysteine protease, putative 0.0048 0.0472 0.1742
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0768 1
Echinococcus granulosus calpain A 0.0219 0.2497 0.2497
Echinococcus granulosus integrin alpha ps 0.0032 0.028 0.028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.073 0.1686
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0149 0.1661 0.1661
Plasmodium vivax unspecified product 0.0034 0.0296 0.0918
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0593 0.1426
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0034 0.0296 0.0296
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0085 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0296 0.028
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0219 0.2497 0.2441
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0296 0.0296
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0325 0.0253
Plasmodium vivax vivapain-2 0.007 0.073 0.2709
Leishmania major calpain family cysteine protease-like protein 0.0066 0.0679 0.152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.073 0.1686
Onchocerca volvulus 0.0034 0.0296 0.0707
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.073 0.1686
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0014 0.0014
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0005 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0219 0.2497 0.7407
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0034 0.0296 0.0574
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0768 0.0768
Echinococcus granulosus cathepsin l cysteine peptidase 0.007 0.073 0.073
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.152
Echinococcus granulosus calmodulin 0.0026 0.021 0.021
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0034 0.0296 0.0918
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0043 0.0043
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0043 0.0043
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0043 0.0043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.073 0.1686
Brugia malayi Inositol-1 0.0036 0.0325 0.0325
Entamoeba histolytica cysteine proteinase, putative 0.0048 0.0472 0.1742
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0034 0.0296 0.0918
Trypanosoma cruzi cysteine protease, putative 0.0048 0.0472 0.0401
Echinococcus granulosus cysteine protease 0.0048 0.0472 0.0472
Trypanosoma cruzi centrin-3 0.0026 0.021 0.0137
Echinococcus granulosus neuronal calcium sensor 0.0026 0.021 0.021
Echinococcus multilocularis cysteine protease 0.007 0.073 0.073
Echinococcus multilocularis cysteine protease 0.007 0.073 0.073
Schistosoma mansoni dopamine-beta-monooxygenase 0.0123 0.1352 0.1352
Trypanosoma cruzi cysteine proteinase, putative 0.0048 0.0472 0.0401
Schistosoma mansoni hypothetical protein 0.0066 0.0679 0.0679
Plasmodium falciparum serine repeat antigen 9 0.0034 0.0296 0.1008
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.061
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0231 0.0231
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0043 0.0043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.073 0.1686
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0325 0.0373
Leishmania major hypothetical protein, unknown function 0.0066 0.0679 0.152
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.073 0.0661
Schistosoma mansoni centrin 0.0026 0.021 0.021
Echinococcus multilocularis cathepsin b 0.0851 1 1
Trypanosoma brucei antigen, putative 0.0219 0.2497 0.7407
Loa Loa (eye worm) hypothetical protein 0.0034 0.0296 0.0296
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0043 0.0043
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0242 0.0242
Brugia malayi cathepsin L-like precursor 0.0055 0.0554 0.0554
Toxoplasma gondii hypothetical protein 0.0066 0.0679 0.1699
Schistosoma mansoni neuronal calcium sensor 0.0026 0.021 0.021
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0376 0.0538
Brugia malayi cathepsin L-like cysteine proteinase 0.0034 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0026 0.021 0.021
Echinococcus multilocularis neurocalcin 0.0026 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0035 0.0313 0.0313
Schistosoma mansoni hypothetical protein 0.0026 0.021 0.021
Schistosoma mansoni hypothetical protein 0.0034 0.0303 0.0303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0472 0.085
Echinococcus granulosus geminin 0.0341 0.3945 0.3945
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0231 0.2636 0.2636
Entamoeba histolytica cysteine protease, putative 0.0048 0.0472 0.1742
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0296 0.028
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0812 0.9538 0.9538
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.073 0.1686
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0066 0.0679 0.1699
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0296 0.028
Echinococcus granulosus pyruvate kinase 0.0021 0.0143 0.0143
Plasmodium falciparum pyruvate kinase 0.004 0.0376 0.1533
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.005 0.0491 0.0491
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.4804 0.4804
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0066 0.0679 0.061
Entamoeba histolytica cysteine protease, putative 0.0048 0.0472 0.1742
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0851 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.073 0.1686
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0315 0.0315
Loa Loa (eye worm) pyruvate kinase 0.004 0.0376 0.0376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.073 0.1686
Entamoeba histolytica cysteine protease, putative 0.0048 0.0472 0.1742
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0851 1 1
Plasmodium falciparum serine repeat antigen 6 0.0034 0.0296 0.1008
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0034 0.0296 0.1008
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.152
Giardia lamblia Cathepsin L-like protease 0.0034 0.0296 0.0485
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0043
Plasmodium vivax pyruvate kinase 2, putative 0.0021 0.0143 0.0286
Echinococcus granulosus Smad4 0.001 0.0014 0.0014
Echinococcus multilocularis integrin alpha ps 0.0067 0.0695 0.0695
Loa Loa (eye worm) hypothetical protein 0.0581 0.6787 0.6787
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0043 0.0043
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0026 0.021 0.0137
Plasmodium vivax vivapain-3 0.0048 0.0472 0.1644
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0034 0.0296 0.0485
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0315 0.0315
Schistosoma mansoni mitochondrial solute carrier 0.0026 0.021 0.021
Entamoeba histolytica cysteine protease, putative 0.0034 0.0296 0.0574
Leishmania major kinesin, putative 0.0153 0.1715 0.4876
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0315 0.0315
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0034 0.0296 0.0918
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.073 0.1686
Schistosoma mansoni calpain C (C02 family) 0.0219 0.2497 0.2497
Loa Loa (eye worm) hypothetical protein 0.004 0.0376 0.0376
Loa Loa (eye worm) programmed cell death protein 6 0.0026 0.021 0.021
Onchocerca volvulus 0.0026 0.021 0.0501
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0768 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0034 0.0296 0.0918
Onchocerca volvulus Cathepsin F homolog 0.007 0.073 0.1744
Echinococcus granulosus calpain 0.0219 0.2497 0.2497
Schistosoma mansoni hypothetical protein 0.0341 0.3945 0.3945
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0376 0.0538
Schistosoma mansoni hypothetical protein 0.0026 0.021 0.021
Schistosoma mansoni ef hand domain family member A2 0.0026 0.021 0.021
Toxoplasma gondii calmodulin CAM1 0.0026 0.021 0.0211
Loa Loa (eye worm) EF hand family protein 0.0026 0.021 0.021
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0607 0.7099 0.7099
Echinococcus multilocularis cathepsin L cysteine protease 0.007 0.073 0.073
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0149 0.1661 0.4699
Loa Loa (eye worm) hypothetical protein 0.0034 0.0296 0.0296
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0325 0.0373
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0074
Brugia malayi calcium-binding protein 0.0026 0.021 0.021
Echinococcus multilocularis neuronal calcium sensor 0.0026 0.021 0.021
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0034 0.0296 0.028
Plasmodium falciparum plasmepsin V 0.0035 0.0315 0.1129
Brugia malayi Smad1 0.001 0.0014 0.0014
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0768 0.0768
Echinococcus multilocularis cathepsin b 0.0851 1 1
Onchocerca volvulus 0.0026 0.021 0.0501
Schistosoma mansoni calmodulin related calcium binding protein 0.0026 0.021 0.021
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.061
Schistosoma mansoni calpain (C02 family) 0.0219 0.2497 0.2497
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.073 0.0661
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.073 0.1686
Echinococcus granulosus EF hand domain containing family member A2 0.0026 0.021 0.021
Onchocerca volvulus 0.0029 0.0242 0.0579
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0034 0.0296 0.028
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0066 0.0679 0.061
Plasmodium falciparum calpain 0.0066 0.0679 0.3532
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0325 0.0373
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0043 0.0043
Echinococcus multilocularis calcium uptake protein 1 0.0026 0.021 0.021
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0768 0.0768
Loa Loa (eye worm) hypothetical protein 0.0362 0.4188 0.4188
Leishmania major cathepsin L-like protease 0.007 0.073 0.1686
Echinococcus multilocularis pyruvate kinase 0.0021 0.0143 0.0143
Plasmodium falciparum serine repeat antigen 3 0.0034 0.0296 0.1008
Chlamydia trachomatis pyruvate kinase 0.004 0.0376 0.5
Trypanosoma brucei calpain-like protein, putative 0.0219 0.2497 0.7407
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0035 0.0315 0.0315
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0034 0.0296 0.0485
Echinococcus multilocularis geminin 0.0341 0.3945 0.3945
Entamoeba histolytica cysteine protease, putative 0.0048 0.0472 0.1742
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0043 0.0043
Schistosoma mansoni cathepsin S (C01 family) 0.0034 0.0296 0.0296
Plasmodium falciparum cysteine proteinase falcipain 1 0.0048 0.0472 0.2168
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0851 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1609 0.1609
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0034 0.0296 0.028
Giardia lamblia Cysteine protease 0.0034 0.0296 0.0485
Loa Loa (eye worm) hypothetical protein 0.007 0.073 0.073
Schistosoma mansoni neuronal calcium sensor 0.0026 0.021 0.021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.073 0.1686
Giardia lamblia Hypothetical protein 0.0034 0.0296 0.0485
Loa Loa (eye worm) calpain family protein 1 0.0427 0.497 0.497
Echinococcus multilocularis hypothetical protein 0.0219 0.2497 0.2497
Brugia malayi cathepsin Z-like cysteine proteinase 0.0034 0.0296 0.0296
Loa Loa (eye worm) aspartyl protease 6 0.0035 0.0315 0.0315
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0325 0.0325
Echinococcus multilocularis cathepsin l cysteine peptidase 0.007 0.073 0.073
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0043 0.0102
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0376 0.0304
Trypanosoma cruzi I/6 autoantigen, putative 0.0026 0.021 0.0137
Trypanosoma cruzi kinesin, putative 0.0153 0.1715 0.1654
Schistosoma mansoni memapsin-2 (A01 family) 0.0035 0.0315 0.0315
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0472 0.0472
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0768 0.0768
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.073 0.1686
Schistosoma mansoni pyruvate kinase 0.004 0.0376 0.0376
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0066 0.0679 0.061
Giardia lamblia Hypothetical protein 0.0026 0.021 0.0211
Trypanosoma brucei Calpain-like protein 2 0.0066 0.0679 0.152
Schistosoma mansoni peptidylglycine monooxygenase 0.0123 0.1352 0.1352
Schistosoma mansoni inositol monophosphatase 0.0036 0.0325 0.0325
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0043 0.0043
Brugia malayi hypothetical protein 0.0214 0.2443 0.2443
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0296 0.028
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0066 0.0679 0.061
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0149 0.1661 0.1661
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0043 0.0043
Trypanosoma cruzi major cysteine proteinase, putative 0.0034 0.0296 0.0224
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0014 0.0014
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0085 0.0085
Brugia malayi EF hand family protein 0.0026 0.021 0.021
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0026 0.021 0.0561
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.061
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0043 0.0043
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0491 0.0491
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0219 0.2497 0.2441
Echinococcus granulosus calumenin 0.0026 0.021 0.021
Onchocerca volvulus 0.007 0.073 0.1744
Schistosoma mansoni reticulocalbin 0.0026 0.021 0.021
Plasmodium falciparum centrin-1 0.0026 0.021 0.0439
Schistosoma mansoni cathepsin D (A01 family) 0.0438 0.5095 0.5095
Entamoeba histolytica calpain family cysteine protease, putative 0.0066 0.0679 0.3117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.073 0.1686
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0409 0.0645
Schistosoma mansoni smad1 5 8 and 0.001 0.0014 0.0014
Schistosoma mansoni integrin alpha 0.015 0.1676 0.1676
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0296 0.0296
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.073 0.1686
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0043 0.0043
Onchocerca volvulus 0.007 0.073 0.1744
Loa Loa (eye worm) hypothetical protein 0.0083 0.0879 0.0879
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0607 0.7099 0.7099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.073 0.1686
Trypanosoma cruzi calmodulin, putative 0.0026 0.021 0.0137
Brugia malayi Cathepsin L-like precursor 0.0055 0.0554 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0043 0.0043
Plasmodium vivax hypothetical protein, conserved 0.0026 0.021 0.0561
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0026 0.021 0.021
Brugia malayi Cathepsin L-like precursor 0.0015 0.0074 0.0074
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.073 0.0661
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0296 0.0296
Echinococcus granulosus calpain 7 C02 family 0.0219 0.2497 0.2497
Echinococcus multilocularis pyruvate kinase 0.004 0.0376 0.0376
Echinococcus multilocularis pyruvate kinase 0.004 0.0376 0.0376
Onchocerca volvulus 0.0055 0.0554 0.1324
Schistosoma mansoni centrin-related 0.0026 0.021 0.021
Echinococcus multilocularis integrin alpha ps 0.0032 0.028 0.028
Plasmodium falciparum plasmepsin VI 0.0149 0.1661 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0055 0.0554 0.0484
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0472 0.085
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.061
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0376 0.196
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0219 0.2497 0.2441
Schistosoma mansoni hypothetical protein 0.0341 0.3945 0.3945
Loa Loa (eye worm) hypothetical protein 0.0034 0.0296 0.0296
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0034 0.0296 0.1008
Trypanosoma cruzi centrin, putative 0.0026 0.021 0.0137
Loa Loa (eye worm) hypothetical protein 0.0851 1 1
Entamoeba histolytica cysteine protease, putative 0.0048 0.0472 0.1742
Onchocerca volvulus 0.0026 0.021 0.0501
Schistosoma mansoni cathepsin F (C01 family) 0.007 0.073 0.073
Plasmodium vivax unspecified product 0.0048 0.0472 0.1644
Brugia malayi ecdysteroid receptor 0.0012 0.0043 0.0043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0296 0.028
Toxoplasma gondii aspartyl protease ASP3 0.0035 0.0315 0.0543
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.073 0.1686
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0034 0.0296 0.0296
Echinococcus multilocularis calumenin 0.0026 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0123 0.1352 0.1352
Toxoplasma gondii cathepsin CPL 0.007 0.073 0.1861
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0231 0.2636 0.2636
Onchocerca volvulus 0.007 0.073 0.1744
Brugia malayi Cathepsin L-like cysteine proteinase 0.0055 0.0554 0.0554
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0043 0.0043
Onchocerca volvulus 0.007 0.073 0.1744
Loa Loa (eye worm) hypothetical protein 0.0118 0.1294 0.1294
Plasmodium falciparum plasmepsin IX 0.0035 0.0315 0.1129
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0296 0.0296
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0113 0.1243 0.1243
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0376 0.0738
Plasmodium falciparum cysteine proteinase falcipain 3 0.007 0.073 0.3869
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0367 0.0708
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0219 0.2497 0.7407
Schistosoma mansoni cathepsin C 0.0034 0.0296 0.0296
Brugia malayi calpain D 0.0066 0.0679 0.0679
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0015 0.0074 0.0074
Toxoplasma gondii preprocathepsin c precursor, putative 0.0034 0.0296 0.0485
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.073 0.1686
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0043 0.0102
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.006 0.0614 0.0614
Plasmodium vivax aspartyl protease, putative 0.0035 0.0315 0.0994
Giardia lamblia Cathepsin L precursor 0.0034 0.0296 0.0485
Plasmodium vivax plasmepsin V, putative 0.0035 0.0315 0.0994
Brugia malayi Cathepsin L-like precursor 0.0055 0.0554 0.0554
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0043 0.0043
Leishmania major cathepsin L-like protease 0.007 0.073 0.1686
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.073 0.1686
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0367 0.1472
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0376 0.0898
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0043 0.0043
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0409 0.0409
Echinococcus granulosus smad 0.001 0.0014 0.0014
Trypanosoma cruzi major cysteine proteinase, putative 0.0034 0.0296 0.0224
Loa Loa (eye worm) inositol-1 0.0036 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0074
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0409 0.0645
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0286 0.3297 0.3248
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0768 1
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0231 0.0142
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0286 0.3297 0.3297
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0014 0.0014
Trypanosoma cruzi centrin, putative 0.0026 0.021 0.0137
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0014 0.0014
Schistosoma mansoni cathepsin D (A01 family) 0.0438 0.5095 0.5095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.073 0.1686
Schistosoma mansoni inositol monophosphatase 0.0036 0.0325 0.0325
Giardia lamblia Cathepsin L precursor 0.0034 0.0296 0.0485
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0026 0.021 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0043 0.0043
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0048 0.0472 0.0472
Toxoplasma gondii cathepsin B 0.0286 0.3297 1
Loa Loa (eye worm) hypothetical protein 0.0515 0.6006 0.6006
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0043 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0043 0.0043
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0066 0.0679 0.061
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.073 0.0661
Brugia malayi steroid hormone receptor 0.0012 0.0043 0.0043
Giardia lamblia Cathepsin B precursor 0.0286 0.3297 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0219 0.2497 0.2441
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0851 1 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0367 0.1041
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0043 0.0043
Trypanosoma brucei hypothetical protein 0.0066 0.0679 0.152
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0066 0.0679 0.061
Schistosoma mansoni neuronal calcium sensor 0.0026 0.021 0.021
Leishmania major cysteine peptidase A (CPA) 0.007 0.073 0.1686
Echinococcus multilocularis smad 0.001 0.0014 0.0014
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0219 0.2497 0.7407
Loa Loa (eye worm) pyruvate kinase 0.004 0.0376 0.0376
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0296 0.0296
Trichomonas vaginalis calpain, putative 0.0066 0.0679 0.152
Loa Loa (eye worm) papain family cysteine protease containing protein 0.007 0.073 0.073
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0066 0.0679 0.152
Echinococcus multilocularis pyruvate kinase 0.0021 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0043
Echinococcus granulosus cathepsin l1 0.0055 0.0554 0.0554
Echinococcus granulosus integrin alpha ps 0.0067 0.0695 0.0695
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0034 0.0296 0.028
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0048 0.0472 0.0472
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0005 0.0005
Echinococcus multilocularis calmodulin 0.0026 0.021 0.021
Echinococcus granulosus cathepsin L cysteine protease 0.0048 0.0472 0.0472
Entamoeba histolytica cysteine protease, putative 0.0048 0.0472 0.1742
Brugia malayi Papain family cysteine protease containing protein 0.007 0.073 0.073
Brugia malayi programmed cell death protein 6 0.0026 0.021 0.021
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0303 0.0303
Echinococcus granulosus calpain 5 0.0219 0.2497 0.2497
Leishmania major cathepsin L-like protease 0.007 0.073 0.1686
Brugia malayi calpain 5 0.0066 0.0679 0.0679
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.061
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0066 0.0679 0.152
Toxoplasma gondii aspartyl protease ASP1 0.0149 0.1661 0.481
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.073 0.1686
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0219 0.2497 0.2441
Plasmodium vivax aspartyl protease, putative 0.0035 0.0315 0.0994
Brugia malayi hypothetical protein 0.0035 0.0315 0.0315
Trypanosoma brucei kinesin, putative 0.0153 0.1715 0.4876
Echinococcus multilocularis cpg binding protein 0.0031 0.0262 0.0262
Trypanosoma brucei cysteine peptidase, putative 0.0066 0.0679 0.152
Plasmodium falciparum cysteine proteinase falcipain 2a 0.007 0.073 0.3869
Brugia malayi MH2 domain containing protein 0.001 0.0014 0.0014
Brugia malayi cathepsin F-like cysteine proteinase 0.0015 0.0074 0.0074
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0043 0.0043
Loa Loa (eye worm) Smad1 0.001 0.0014 0.0014
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0409 0.1384
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0034 0.0296 0.0485
Brugia malayi Cathepsin L-like precursor 0.007 0.073 0.073
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0034 0.0296 0.0918
Entamoeba histolytica cysteine protease, putative 0.0034 0.0296 0.0574
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0296 0.0296
Trypanosoma cruzi calmodulin, putative 0.0026 0.021 0.0137
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0066 0.0679 0.061
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0085 0.0085
Brugia malayi CXXC zinc finger family protein 0.0029 0.0242 0.0242
Toxoplasma gondii cathepsin CPC1 0.0034 0.0296 0.0485
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0231 0.2636 0.2636
Loa Loa (eye worm) calpain family protein 1 0.0581 0.6787 0.6787
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0043 0.0043
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0043 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.073 0.1686
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0043 0.0043
Echinococcus granulosus integrin alpha 3 0.0115 0.1261 0.1261
Giardia lamblia Cathepsin B precursor 0.0034 0.0296 0.0485
Plasmodium falciparum cysteine proteinase falcipain 2b 0.007 0.073 0.3869
Trypanosoma brucei calpain-like protein, putative 0.0219 0.2497 0.7407
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0315 0.0315
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.152
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.007 0.073 0.073
Loa Loa (eye worm) hypothetical protein 0.0055 0.0554 0.0554
Trypanosoma cruzi caltractin, putative 0.0026 0.021 0.0137
Schistosoma mansoni calmodulin 0.0026 0.021 0.021
Trypanosoma brucei calpain-like protein, putative 0.0219 0.2497 0.7407
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0026 0.021 0.021
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0062 0.0636 0.0636
Onchocerca volvulus 0.007 0.073 0.1744
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0034 0.0296 0.028
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0034 0.0296 0.028
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.1636 0.1636
Entamoeba histolytica cysteine protease, putative 0.0048 0.0472 0.1742
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0325 0.5
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0607 0.7099 0.7099
Onchocerca volvulus 0.0362 0.4188 1
Schistosoma mansoni cathepsin F (C01 family) 0.0055 0.0554 0.0554
Echinococcus granulosus cpg binding protein 0.0031 0.0262 0.0262
Echinococcus multilocularis EF hand domain containing family member A2 0.0026 0.021 0.021
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0034 0.0296 0.0296
Leishmania major cathepsin L-like protease 0.007 0.073 0.1686
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0315 0.0315
Brugia malayi Cathepsin L-like precursor 0.007 0.073 0.073
Schistosoma mansoni smad 0.001 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0085 0.0085
Onchocerca volvulus 0.0012 0.0043 0.0102
Giardia lamblia Hypothetical protein 0.0034 0.0296 0.0485
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0043 0.0043
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0043 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0034 0.0296 0.028
Loa Loa (eye worm) ctsf protein 0.007 0.073 0.073
Entamoeba histolytica cysteine protease, putative 0.0034 0.0296 0.0574
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0043 0.0043
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0043 0.0043
Entamoeba histolytica cysteine protease, putative 0.0048 0.0472 0.1742
Trypanosoma cruzi conserved protein 0.0066 0.0679 0.061
Toxoplasma gondii EFHC1, putative 0.0026 0.021 0.0211
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0026 0.021 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0296 0.028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0043
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0026 0.021 0.0137
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0315 0.0315
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.0315 0.0994
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.073 0.1686
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0043
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0376 0.0898
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0026 0.021 0.021
Echinococcus multilocularis pyruvate kinase 0.0032 0.0275 0.0275
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0034 0.0296 0.0918
Loa Loa (eye worm) hypothetical protein 0.0066 0.0679 0.0679
Echinococcus granulosus centrin 2 0.0026 0.021 0.021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.073 0.1686
Brugia malayi calpain 7 0.0219 0.2497 0.2497
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.152
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.1636 0.1636
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0296 0.0296
Leishmania major cathepsin L-like protease 0.007 0.073 0.1686
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0296 0.028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0016 0.0085 0.0085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0043 0.0043
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0325 0.0577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0472 0.085
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0034 0.0296 0.0918
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.152
Echinococcus granulosus calbindin 32 0.0026 0.021 0.021
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0043 0.0043
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0219 0.2497 0.2441
Leishmania major cathepsin L-like protease 0.007 0.073 0.1686
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0014 0.0014
Toxoplasma gondii EF hand domain-containing protein 0.0026 0.021 0.0211
Trichomonas vaginalis hypothetical protein 0.0066 0.0679 0.152
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0066 0.0679 0.152
Echinococcus multilocularis calpain 5 0.0219 0.2497 0.2497
Leishmania major calpain protease-like protein 0.0066 0.0679 0.152
Trypanosoma cruzi calmodulin, putative 0.0026 0.021 0.0137
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0034 0.0296 0.0918
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.152
Echinococcus granulosus EF HAND 1 calcium binding site 0.0026 0.021 0.021
Trypanosoma brucei Calpain-like protein CALP1.3 0.0066 0.0679 0.152
Giardia lamblia Cysteine protease 0.0034 0.0296 0.0485
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0026 0.021 0.0137
Brugia malayi Cathepsin L-like precursor 0.007 0.073 0.073
Brugia malayi Calmodulin-like protein 0.0026 0.021 0.021
Plasmodium falciparum serine repeat antigen 4 0.0034 0.0296 0.1008
Plasmodium falciparum serine repeat antigen 2 0.0034 0.0296 0.1008
Schistosoma mansoni cathepsin s 0.0015 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0427 0.497 0.497
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0219 0.2497 0.7407
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0043 0.0043
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0768 0.1808
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.152
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0581 0.6787 0.6787
Schistosoma mansoni cpg binding protein 0.0031 0.0262 0.0262
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0066 0.0679 0.152
Plasmodium falciparum serine repeat antigen 1 0.0034 0.0296 0.1008
Leishmania major cathepsin L-like protease 0.007 0.073 0.1686
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0296 0.028
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.152
Loa Loa (eye worm) hypothetical protein 0.0034 0.0296 0.0296
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0472 0.0472
Entamoeba histolytica protein kinase, putative 0.0153 0.1715 1
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0012 0.0043 0.0043
Loa Loa (eye worm) cathepsin B 0.0286 0.3297 0.3297
Plasmodium falciparum serine repeat antigen 5 0.0034 0.0296 0.1008
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0066 0.0679 0.152
Mycobacterium ulcerans pyruvate kinase 0.004 0.0376 0.1147
Plasmodium vivax serine-repeat antigen (SERA) 0.0034 0.0296 0.0918
Trichomonas vaginalis calpain, putative 0.0066 0.0679 0.152
Giardia lamblia Cathepsin L-like protease 0.0034 0.0296 0.0485
Giardia lamblia Cathepsin L precursor 0.0034 0.0296 0.0485
Entamoeba histolytica cysteine proteinase, putative 0.0048 0.0472 0.1742
Giardia lamblia Cathepsin B precursor 0.0286 0.3297 1
Schistosoma mansoni smad1 5 8 and 0.001 0.0014 0.0014
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0066 0.0679 0.152
Schistosoma mansoni hypothetical protein 0.0016 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0149 0.1661 0.1661
Plasmodium falciparum plasmepsin VIII, putative 0.0035 0.0315 0.1129
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0851 1 1
Giardia lamblia Pyruvate kinase 0.004 0.0376 0.0738
Echinococcus multilocularis calmodulin 0.0026 0.021 0.021
Echinococcus multilocularis programmed cell death protein 0.0026 0.021 0.021
Trypanosoma brucei calpain, putative 0.0066 0.0679 0.152
Schistosoma mansoni reticulocalbin 0.0026 0.021 0.021
Echinococcus multilocularis cathepsin l cysteine peptidase 0.007 0.073 0.073
Giardia lamblia Cathepsin B precursor 0.0286 0.3297 1
Brugia malayi Pepsin A precursor 0.0035 0.0315 0.0315
Brugia malayi cathepsin F-like cysteine proteinase 0.0034 0.0296 0.0296
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.1588 0.1588
Schistosoma mansoni cathepsin B (C01 family) 0.0034 0.0296 0.0296
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0066 0.0679 0.061
Echinococcus multilocularis pyruvate kinase 0.0021 0.0143 0.0143
Giardia lamblia Cysteine protease 0.0034 0.0296 0.0485
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0085 0.0085
Trypanosoma brucei calpain, putative 0.0066 0.0679 0.152
Plasmodium vivax aspartyl protease, putative 0.0035 0.0315 0.0994
Schistosoma mansoni rab 0.0026 0.021 0.021
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0034 0.0296 0.028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0043 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0286 0.3297 1
Schistosoma mansoni Mername-AA248 (C02 family) 0.0219 0.2497 0.2497
Echinococcus granulosus calcium uptake protein 1 0.0026 0.021 0.021
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0066 0.0679 0.152
Echinococcus granulosus cathepsin b 0.0851 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0043 0.0043
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0325 0.0253
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0043 0.0043
Schistosoma mansoni cpg binding protein 0.0029 0.0242 0.0242
Leishmania major cathepsin L-like protease 0.007 0.073 0.1686
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0607 0.7099 0.7099
Plasmodium vivax vivapain-2 0.007 0.073 0.2709
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0026 0.021 0.0137
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0085 0.0085
Toxoplasma gondii calcium-dependent protein kinase 0.0026 0.021 0.0211
Schistosoma mansoni smad1 5 8 and 0.001 0.0014 0.0014
Onchocerca volvulus Cathepsin L homolog 0.007 0.073 0.1744
Plasmodium falciparum serine repeat antigen 7 0.0034 0.0296 0.1008
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.007 0.073 0.1686
Brugia malayi Integrin alpha pat-2 precursor 0.015 0.1676 0.1676
Giardia lamblia Cathepsin L precursor 0.0034 0.0296 0.0485
Schistosoma mansoni calpain-7 (C02 family) 0.0219 0.2497 0.2497
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.073 0.1686
Brugia malayi MH1 domain containing protein 0.001 0.0014 0.0014
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0034 0.0296 0.0296
Brugia malayi calpain family protein 1 0.0581 0.6787 0.6787
Entamoeba histolytica calpain large subunit domain III containing protein 0.0153 0.1715 1
Plasmodium vivax calpain, putative 0.0219 0.2497 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0043 0.0043
Brugia malayi Cathepsin L-like precursor 0.007 0.073 0.073
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0043 0.0043
Giardia lamblia Cathepsin B precursor 0.0034 0.0296 0.0485
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0034 0.0296 0.0918
Onchocerca volvulus 0.0035 0.0315 0.0751
Echinococcus multilocularis GPCR, family 2 0.0016 0.0085 0.0085
Entamoeba histolytica cysteine protease, putative 0.0048 0.0472 0.1742
Echinococcus multilocularis cathepsin L 0.0048 0.0472 0.0472
Loa Loa (eye worm) hypothetical protein 0.0028 0.0231 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0296 0.028
Echinococcus multilocularis cathepsin L 0.0034 0.0296 0.0296
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0149 0.1661 0.1661
Brugia malayi MH2 domain containing protein 0.0144 0.1609 0.1609
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0055 0.0554 0.0554
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0066 0.0679 0.061
Trypanosoma brucei calpain-like protein, putative 0.0219 0.2497 0.7407
Plasmodium falciparum plasmepsin VII 0.0035 0.0315 0.1129
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.152
Leishmania major pyruvate kinase 0.004 0.0376 0.0538
Brugia malayi Cathepsin L-like precursor 0.007 0.073 0.073
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0296 0.0296
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.152
Schistosoma mansoni calmodulin 0.0026 0.021 0.021
Toxoplasma gondii cathepsin CPC2 0.0034 0.0296 0.0485
Schistosoma mansoni cathepsin F (C01 family) 0.007 0.073 0.073
Brugia malayi nuclear hormone receptor 0.0012 0.0043 0.0043
Trypanosoma brucei pyruvate kinase 1 0.004 0.0376 0.0538
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0376 0.0898
Plasmodium vivax pyruvate kinase, putative 0.004 0.0376 0.1247
Plasmodium vivax vivapain-1 0.0048 0.0472 0.1644
Echinococcus granulosus programmed cell death protein 0.0026 0.021 0.021
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.061
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0034 0.0296 0.0918
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0043 0.0043
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0005 0.0005
Brugia malayi MH1 domain containing protein 0.001 0.0014 0.0014
Entamoeba histolytica cysteine proteinase 2 0.0048 0.0472 0.1742
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0491 0.0491
Entamoeba histolytica cysteine protease, putative 0.0048 0.0472 0.1742
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0554 0.1116
Echinococcus granulosus cathepsin l1 0.007 0.073 0.073
Entamoeba histolytica cysteine protease, putative 0.0034 0.0296 0.0574
Loa Loa (eye worm) hypothetical protein 0.0231 0.2636 0.2636
Echinococcus granulosus GPCR family 2 0.0016 0.0085 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.007 0.073 0.1686
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0043 0.0043
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0066 0.0685 0.154
Loa Loa (eye worm) acetyltransferase 0.0147 0.1636 0.1636
Trichomonas vaginalis calpain, putative 0.0066 0.0679 0.152
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0409 0.0843
Loa Loa (eye worm) hypothetical protein 0.0034 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0043
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.073 0.0661
Plasmodium vivax aspartyl proteinase, putative 0.0149 0.1661 0.6549
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.073 0.1686
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0043 0.0043
Toxoplasma gondii troponin c, isotype gamma, putative 0.0026 0.021 0.0211
Plasmodium falciparum plasmepsin X 0.0035 0.0315 0.1129
Schistosoma mansoni Smad4 0.001 0.0014 0.0014
Echinococcus granulosus pyruvate kinase 0.004 0.0376 0.0376
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0034 0.0296 0.0574
Plasmodium falciparum plasmepsin II 0.0149 0.1661 1
Brugia malayi fibroinase precursor 0.0034 0.0296 0.0296
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0629 0.0629
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0325 0.0765
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0376 0.0538
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0034 0.0296 0.0296
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0768 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0296 0.028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0043
Giardia lamblia Cathepsin L precursor 0.0034 0.0296 0.0485
Onchocerca volvulus 0.007 0.073 0.1744
Brugia malayi Eukaryotic aspartyl protease family protein 0.0035 0.0315 0.0315
Schistosoma mansoni calpain-2 (C02 family) 0.0066 0.0679 0.0679
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0066 0.0679 0.152
Loa Loa (eye worm) hypothetical protein 0.0034 0.0303 0.0303

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4611 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.6513 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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