Detailed information for compound 1515728

Basic information

Technical information
  • TDR Targets ID: 1515728
  • Name: N-(4-tert-butylphenyl)-1-oxidopyridin-1-ium-4 -carboxamide
  • MW: 270.326 | Formula: C16H18N2O2
  • H donors: 1 H acceptors: 2 LogP: 2.36 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][n+]1ccc(cc1)C(=O)Nc1ccc(cc1)C(C)(C)C
  • InChi: 1S/C16H18N2O2/c1-16(2,3)13-4-6-14(7-5-13)17-15(19)12-8-10-18(20)11-9-12/h4-11H,1-3H3,(H,17,19)
  • InChiKey: AKMBAHUBEZFKSY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-tert-butylphenyl)-1-oxido-pyridin-1-ium-4-carboxamide
  • N-(4-tert-butylphenyl)-1-oxido-4-pyridin-1-iumcarboxamide
  • ZINC03218920
  • T0501-4788

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, putative 0.0253 0.1056 0.0856
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.1988 0.5593
Plasmodium vivax unspecified product 0.0253 0.1056 0.3687
Brugia malayi programmed cell death protein 6 0.0088 0.0219 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.1988 0.5593
Schistosoma mansoni cathepsin D (A01 family) 0.0212 0.0846 0.0846
Onchocerca volvulus Cathepsin L homolog 0.0436 0.1988 0.4306
Trypanosoma cruzi cruzipain precursor, putative 0.0436 0.1988 0.1809
Loa Loa (eye worm) cysteine protease 0.0436 0.1988 0.1988
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0155 0.0557 0.0346
Onchocerca volvulus 0.0436 0.1988 0.4306
Loa Loa (eye worm) hypothetical protein 0.1432 0.7049 0.7049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.1056 0.2646
Loa Loa (eye worm) hypothetical protein 0.1052 0.5117 0.5117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.1988 0.5593
Echinococcus granulosus calpain 7 C02 family 0.0535 0.2489 0.2489
Brugia malayi cathepsin L precursor 0.0128 0.042 0.042
Echinococcus multilocularis gamma secretase subunit aph 1 0.0245 0.1015 0.1015
Leishmania major cathepsin L-like protease 0.0436 0.1988 0.5593
Plasmodium falciparum cysteine proteinase falcipain 3 0.0436 0.1988 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0128 0.042 0.0611
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0128 0.042 0.0887
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0128 0.042 0.1137
Loa Loa (eye worm) calmodulin-like protein 0.0088 0.0219 0.0219
Entamoeba histolytica calpain family cysteine protease, putative 0.0155 0.0557 0.1914
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.1071
Plasmodium vivax hypothetical protein, conserved 0.009 0.0227 0.0037
Schistosoma mansoni calmodulin related calcium binding protein 0.0088 0.0219 0.0219
Schistosoma mansoni calmodulin 0.0088 0.0219 0.0219
Brugia malayi calpain 5 0.038 0.17 0.17
Giardia lamblia Cathepsin B precursor 0.0711 0.3383 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.1988 0.5593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.1988 0.5593
Echinococcus granulosus programmed cell death protein 0.0092 0.0237 0.0237
Trypanosoma brucei calpain, putative 0.0155 0.0557 0.1071
Trypanosoma brucei calpain-like protein, putative 0.0535 0.2489 0.7175
Entamoeba histolytica calpain large subunit domain III containing protein 0.038 0.17 0.8372
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0155 0.0557 0.0346
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0535 0.2489 0.2321
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0535 0.2489 0.7175
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0128 0.042 0.1137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.1988 0.5593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.1988 0.5593
Giardia lamblia Encystation-specific protease 0.0128 0.042 0.0611
Giardia lamblia Cathepsin L-like protease 0.0128 0.042 0.0611
Brugia malayi Cathepsin L-like precursor 0.0311 0.1353 0.1353
Entamoeba histolytica cysteine protease, putative 0.0253 0.1056 0.473
Trichomonas vaginalis calmodulin, putative 0.009 0.0227 0.0027
Echinococcus multilocularis calpain A 0.1522 0.7507 0.7507
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0125 0.0405 0.0405
Entamoeba histolytica cysteine protease, putative 0.0436 0.1988 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.0405 0.0405
Plasmodium falciparum serine repeat antigen 8 0.0128 0.042 0.1137
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0088 0.0219 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.1988 0.5593
Trypanosoma brucei calpain-like protein, putative 0.0535 0.2489 0.7175
Loa Loa (eye worm) hypothetical protein 0.1276 0.626 0.626
Entamoeba histolytica cysteine protease, putative 0.0253 0.1056 0.473
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.0346
Trypanosoma brucei calmodulin, putative 0.009 0.0227 0.0027
Leishmania major calpain protease-like protein 0.0155 0.0557 0.1071
Leishmania major cathepsin L-like protease 0.0436 0.1988 0.5593
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0253 0.1056 0.1056
Plasmodium falciparum plasmepsin X 0.0185 0.0708 0.2766
Loa Loa (eye worm) hypothetical protein 0.0311 0.1353 0.1353
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0436 0.1988 0.1988
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.009 0.0227 0.0009
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0436 0.1988 1
Brugia malayi Cathepsin L-like precursor 0.0436 0.1988 0.1988
Trypanosoma cruzi Aph-1 protein, putative 0.0095 0.0254 0.0037
Toxoplasma gondii preprocathepsin c precursor, putative 0.0128 0.042 0.0636
Plasmodium falciparum serine repeat antigen 4 0.0128 0.042 0.1137
Schistosoma mansoni calpain-2 (C02 family) 0.0155 0.0557 0.0557
Leishmania major cysteine peptidase A (CPA) 0.0436 0.1988 0.5593
Giardia lamblia Cysteine protease 0.0128 0.042 0.0611
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0155 0.0557 0.0346
Echinococcus multilocularis cathepsin L 0.0128 0.042 0.042
Schistosoma mansoni mitochondrial solute carrier 0.0088 0.0219 0.0219
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0155 0.0557 0.1071
Entamoeba histolytica grainin, putative 0.009 0.0227 0.0048
Schistosoma mansoni cathepsin F (C01 family) 0.0436 0.1988 0.1988
Entamoeba histolytica protein kinase, putative 0.038 0.17 0.8372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.1988 0.5593
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.0346
Echinococcus granulosus cathepsin l1 0.0436 0.1988 0.1988
Echinococcus granulosus calmodulin 0.0088 0.0219 0.0219
Schistosoma mansoni hypothetical protein 0.0088 0.0219 0.0219
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0128 0.042 0.0887
Giardia lamblia Cathepsin L precursor 0.0128 0.042 0.0611
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.1071
Brugia malayi Papain family cysteine protease containing protein 0.0128 0.042 0.042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.1988 0.5593
Plasmodium vivax unspecified product 0.0125 0.0405 0.0819
Toxoplasma gondii hypothetical protein 0.0155 0.0557 0.1071
Loa Loa (eye worm) ctsf protein 0.0436 0.1988 0.1988
Plasmodium falciparum serine repeat antigen 6 0.0128 0.042 0.1137
Giardia lamblia Cathepsin B precursor 0.0128 0.042 0.0611
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0128 0.042 0.0887
Giardia lamblia Cathepsin B precursor 0.0128 0.042 0.0611
Schistosoma mansoni neuronal calcium sensor 0.0088 0.0219 0.0219
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0128 0.042 0.042
Brugia malayi Papain family cysteine protease containing protein 0.0128 0.042 0.042
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0535 0.2489 0.7175
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0128 0.042 0.0887
Leishmania major cathepsin L-like protease 0.0436 0.1988 0.5593
Trypanosoma brucei centrin-3 0.0092 0.0237 0.0057
Loa Loa (eye worm) EF hand family protein 0.0088 0.0219 0.0219
Giardia lamblia Cathepsin B precursor 0.0128 0.042 0.0611
Onchocerca volvulus 0.0311 0.1353 0.2759
Plasmodium vivax vivapain-2 0.0436 0.1988 0.7795
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0155 0.0557 0.1071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.1988 0.5593
Loa Loa (eye worm) hypothetical protein 0.0155 0.0557 0.0557
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0128 0.042 0.0887
Onchocerca volvulus 0.009 0.0227 0.0021
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0155 0.0557 0.0346
Entamoeba histolytica cysteine protease, putative 0.0253 0.1056 0.473
Trypanosoma cruzi cruzipain precursor, putative 0.0125 0.0405 0.019
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0535 0.2489 0.2321
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0436 0.1988 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0535 0.2489 0.2321
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0088 0.0219 0.0219
Echinococcus granulosus calbindin 32 0.009 0.0227 0.0227
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0128 0.042 0.0636
Loa Loa (eye worm) hypothetical protein 0.0128 0.042 0.042
Entamoeba histolytica hypothetical protein 0.0128 0.042 0.1137
Schistosoma mansoni calpain-7 (C02 family) 0.0539 0.2507 0.2507
Trypanosoma cruzi cysteine proteinase, putative 0.0253 0.1056 0.0856
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.1056 0.473
Schistosoma mansoni neuronal calcium sensor 0.0088 0.0219 0.0219
Giardia lamblia Cathepsin L-like protease 0.0128 0.042 0.0611
Loa Loa (eye worm) hypothetical protein 0.0436 0.1988 0.1988
Onchocerca volvulus 0.0436 0.1988 0.4306
Schistosoma mansoni rab 0.0088 0.0219 0.0219
Brugia malayi calpain 5 0.0155 0.0557 0.0557
Loa Loa (eye worm) calpain family protein 1 0.1432 0.7049 0.7049
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0128 0.042 0.042
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0128 0.042 0.042
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.1056 0.473
Entamoeba histolytica cysteine protease, putative 0.0253 0.1056 0.473
Giardia lamblia Cysteine protease 0.0128 0.042 0.0611
Trypanosoma brucei Aph-1 protein, putative 0.0095 0.0254 0.0113
Echinococcus granulosus calumenin 0.009 0.0227 0.0227
Trypanosoma brucei Calpain-like protein 2 0.0155 0.0557 0.1071
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0155 0.0557 0.0346
Schistosoma mansoni cathepsin B (C01 family) 0.0128 0.042 0.042
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0088 0.0219 0.0219
Brugia malayi gamma-secretase subunit aph-1 0.0245 0.1015 0.1015
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0128 0.042 0.0887
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.1071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.1988 0.5593
Loa Loa (eye worm) hypothetical protein 0.0311 0.1353 0.1353
Echinococcus multilocularis calcium uptake protein 1 0.009 0.0227 0.0227
Plasmodium vivax unspecified product 0.0128 0.042 0.0887
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0128 0.042 0.0636
Loa Loa (eye worm) hypothetical protein 0.0128 0.042 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.042 0.0636
Giardia lamblia Cathepsin L precursor 0.0128 0.042 0.0611
Echinococcus granulosus calpain A 0.1522 0.7507 0.7507
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.1056 0.473
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.1988 0.5593
Onchocerca volvulus 0.0436 0.1988 0.4306
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0155 0.0557 0.0346
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0311 0.1353 0.3584
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.1071
Plasmodium vivax vivapain-2 0.0436 0.1988 0.7795
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.0346
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.0346
Trypanosoma cruzi Aph-1 protein, putative 0.0095 0.0254 0.0037
Echinococcus multilocularis calpain family protein 1, d 0.1052 0.5117 0.5117
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0128 0.042 0.0887
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0128 0.042 0.1137
Leishmania major cathepsin L-like protease 0.0436 0.1988 0.5593
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0128 0.042 0.0636
Echinococcus multilocularis cysteine protease 0.0436 0.1988 0.1988
Brugia malayi Cathepsin L-like cysteine proteinase 0.0311 0.1353 0.1353
Onchocerca volvulus Cathepsin F homolog 0.0436 0.1988 0.4306
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0155 0.0557 0.0346
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.1988 0.5593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.1988 0.5593
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0253 0.1056 0.1056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.1056 0.2646
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.042 0.0636
Schistosoma mansoni hypothetical protein 0.0155 0.0557 0.0557
Plasmodium vivax vivapain-3 0.0253 0.1056 0.3687
Plasmodium vivax aspartyl protease, putative 0.0185 0.0708 0.2156
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0128 0.042 0.042
Entamoeba histolytica cysteine protease, putative 0.0128 0.042 0.1137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.042 0.0636
Loa Loa (eye worm) hypothetical protein 0.0125 0.0405 0.0405
Brugia malayi Papain family cysteine protease containing protein 0.0253 0.1056 0.1056
Entamoeba histolytica hypothetical protein, conserved 0.009 0.0227 0.0048
Entamoeba histolytica cysteine proteinase 1, putative 0.0253 0.1056 0.473
Entamoeba histolytica cysteine protease, putative 0.0253 0.1056 0.473
Trypanosoma brucei calpain, putative 0.0155 0.0557 0.1071
Loa Loa (eye worm) calpain 0.0535 0.2489 0.2489
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0128 0.042 0.1137
Trichomonas vaginalis calpain, putative 0.0155 0.0557 0.1071
Echinococcus multilocularis neuronal calcium sensor 0.0088 0.0219 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0711 0.3383 1
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0155 0.0557 0.1071
Trypanosoma brucei Calpain-like protein 1.1 0.0155 0.0557 0.1071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.1988 0.5593
Plasmodium vivax calpain, putative 0.0535 0.2489 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0711 0.3383 1
Echinococcus granulosus calcium uptake protein 1 0.009 0.0227 0.0227
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.1988 0.5593
Brugia malayi calpain family protein 1 0.1432 0.7049 0.7049
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0436 0.1988 0.5593
Brugia malayi cathepsin Z-like cysteine proteinase 0.0128 0.042 0.042
Echinococcus multilocularis EF hand domain containing family member A2 0.009 0.0227 0.0227
Brugia malayi Papain family cysteine protease containing protein 0.0128 0.042 0.042
Schistosoma mansoni Mername-AA248 (C02 family) 0.0535 0.2489 0.2489
Schistosoma mansoni reticulocalbin 0.0088 0.0219 0.0219
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.1071
Trichomonas vaginalis calmodulin, putative 0.0092 0.0237 0.0057
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0128 0.042 0.0611
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.1071
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0711 0.3383 0.3383
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0128 0.042 0.042
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0088 0.0219 0.0219
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0128 0.042 0.0887
Trypanosoma brucei Calpain-like protein 1.2 0.0155 0.0557 0.1071
Brugia malayi Cathepsin L-like precursor 0.0436 0.1988 0.1988
Echinococcus granulosus centrin 2 0.0088 0.0219 0.0219
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0155 0.0557 0.1071
Echinococcus multilocularis hypothetical protein 0.0535 0.2489 0.2489
Giardia lamblia Cathepsin B precursor 0.0128 0.042 0.0611
Giardia lamblia Cysteine protease 0.0128 0.042 0.0611
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.1071
Loa Loa (eye worm) hypothetical protein 0.0088 0.0219 0.0219
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.1071
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.1071
Trypanosoma brucei hypothetical protein 0.0155 0.0557 0.1071
Trypanosoma brucei kinesin, putative 0.038 0.17 0.4683
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0535 0.2489 0.2321
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0155 0.0557 0.1071
Echinococcus multilocularis centrin 2 0.0088 0.0219 0.0219
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1432 0.7049 0.7049
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0535 0.2489 0.7175
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.042 0.0636
Trypanosoma brucei calpain-like protein, putative 0.0535 0.2489 0.7175
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0535 0.2489 0.7175
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.1071
Onchocerca volvulus Cathepsin L homolog 0.0128 0.042 0.049
Brugia malayi Calmodulin-like protein 0.0088 0.0219 0.0219
Trypanosoma brucei Calpain-like protein CALP1.3 0.0155 0.0557 0.1071
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0128 0.042 0.042
Entamoeba histolytica cysteine protease, putative 0.0253 0.1056 0.473
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.152 0.7499 0.7499
Entamoeba histolytica cysteine protease, putative 0.0253 0.1056 0.473
Trypanosoma cruzi cysteine proteinase, putative 0.0253 0.1056 0.0856
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0128 0.042 0.0611
Echinococcus granulosus EF hand domain containing family member A2 0.009 0.0227 0.0227
Brugia malayi calpain family protein 1 0.1432 0.7049 0.7049
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.0346
Leishmania major calpain family cysteine protease-like protein 0.0155 0.0557 0.1071
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0128 0.042 0.1137
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0535 0.2489 0.2321
Trypanosoma cruzi major cysteine proteinase, putative 0.0128 0.042 0.0206
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0155 0.0557 0.0346
Loa Loa (eye worm) hypothetical protein 0.0311 0.1353 0.1353
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0128 0.042 0.0636
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.152 0.7499 0.7499
Echinococcus granulosus EF hand domain containing family member A2 0.0088 0.0219 0.0219
Toxoplasma gondii calmodulin CAM1 0.009 0.0227 0.0027
Trichomonas vaginalis calpain, putative 0.0155 0.0557 0.1071
Echinococcus multilocularis calumenin 0.009 0.0227 0.0227
Plasmodium falciparum serine repeat antigen 1 0.0128 0.042 0.1137
Loa Loa (eye worm) calpain D 0.0155 0.0557 0.0557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.042 0.0636
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.0557 0.1071
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0128 0.042 0.042
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.0346
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.0346
Echinococcus multilocularis cathepsin L cysteine protease 0.0436 0.1988 0.1988
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0155 0.0557 0.1071
Onchocerca volvulus Cathepsin L homolog 0.0436 0.1988 0.4306
Brugia malayi cathepsin F-like cysteine proteinase 0.0128 0.042 0.042
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0245 0.1015 0.1015
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0128 0.042 0.0611
Schistosoma mansoni cathepsin S (C01 family) 0.0128 0.042 0.042
Entamoeba histolytica cysteine protease, putative 0.0128 0.042 0.1137
Toxoplasma gondii cathepsin CPL 0.0436 0.1988 0.5593
Echinococcus granulosus neurocalcin 0.0088 0.0219 0.0219
Schistosoma mansoni reticulocalbin 0.009 0.0227 0.0227
Schistosoma mansoni centrin-related 0.0088 0.0219 0.0219
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.1071
Trypanosoma cruzi conserved protein 0.0155 0.0557 0.0346
Brugia malayi Cathepsin L-like precursor 0.0436 0.1988 0.1988
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.1071
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.1071
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0155 0.0557 0.1071
Brugia malayi Papain family cysteine protease containing protein 0.0436 0.1988 0.1988
Toxoplasma gondii aspartyl protease ASP3 0.0185 0.0708 0.1547
Brugia malayi Cathepsin L-like precursor 0.0436 0.1988 0.1988
Brugia malayi Cathepsin L-like precursor 0.0125 0.0405 0.0405
Brugia malayi fibroinase precursor 0.0128 0.042 0.042
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0128 0.042 0.042
Onchocerca volvulus 0.0436 0.1988 0.4306
Brugia malayi calcium-binding protein 0.0088 0.0219 0.0219
Brugia malayi calpain 7 0.0535 0.2489 0.2489
Toxoplasma gondii cathepsin B 0.0711 0.3383 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.042 0.042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.1988 0.5593
Brugia malayi cathepsin F-like cysteine proteinase 0.0125 0.0405 0.0405
Schistosoma mansoni cathepsin s 0.0125 0.0405 0.0405
Entamoeba histolytica cysteine protease, putative 0.0253 0.1056 0.473
Loa Loa (eye worm) cathepsin B 0.0711 0.3383 0.3383
Loa Loa (eye worm) hypothetical protein 0.0125 0.0405 0.0405
Giardia lamblia Cathepsin L precursor 0.0128 0.042 0.0611
Plasmodium vivax aspartyl protease, putative 0.0185 0.0708 0.2156
Schistosoma mansoni gamma-secretase subunit aph-1 0.0245 0.1015 0.1015
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0253 0.1056 0.1056
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.152 0.7499 0.7499
Schistosoma mansoni hypothetical protein 0.0088 0.0219 0.0219
Plasmodium vivax serine-repeat antigen (SERA) 0.0128 0.042 0.0887
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.1071
Plasmodium falciparum calpain 0.0155 0.0557 0.1914
Giardia lamblia Hypothetical protein 0.0128 0.042 0.0611
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0436 0.1988 0.5593
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0535 0.2489 0.2321
Brugia malayi cathepsin L-like precursor 0.0311 0.1353 0.1353
Plasmodium falciparum plasmepsin IX 0.0185 0.0708 0.2766
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0155 0.0557 0.1071
Entamoeba histolytica cysteine protease, putative 0.0253 0.1056 0.473
Loa Loa (eye worm) hypothetical protein 0.0128 0.042 0.042
Schistosoma mansoni cathepsin F (C01 family) 0.0436 0.1988 0.1988
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0535 0.2489 0.2321
Loa Loa (eye worm) fibroinase 0.0436 0.1988 0.1988
Echinococcus granulosus cathepsin L cysteine protease 0.0253 0.1056 0.1056
Leishmania major hypothetical protein, conserved 0.0155 0.0557 0.1071
Trichomonas vaginalis hypothetical protein 0.0155 0.0557 0.1071
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0128 0.042 0.0636
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0535 0.2489 0.2321
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0155 0.0557 0.0346
Entamoeba histolytica grainin 2 0.0092 0.0237 0.0103
Onchocerca volvulus 0.0436 0.1988 0.4306
Echinococcus multilocularis programmed cell death protein 0.0092 0.0237 0.0237
Brugia malayi cathepsin L-like cysteine proteinase 0.0128 0.042 0.042
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0125 0.0405 0.0405
Trichomonas vaginalis calpain, putative 0.0155 0.0557 0.1071
Entamoeba histolytica cysteine proteinase, putative 0.0311 0.1353 0.6407
Trypanosoma cruzi cysteine peptidase, putative 0.0436 0.1988 0.1809
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.1988 0.5593
Schistosoma mansoni ef hand domain family member A2 0.0088 0.0219 0.0219
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0128 0.042 0.0636
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.1988 0.5593
Echinococcus granulosus cathepsin L cysteine proteinase 0.0436 0.1988 0.1988
Entamoeba histolytica cysteine proteinase 2 0.0253 0.1056 0.473
Echinococcus multilocularis cathepsin L cysteine protease 0.0436 0.1988 0.1988
Schistosoma mansoni cathepsin F (C01 family) 0.0311 0.1353 0.1353
Trypanosoma brucei cysteine peptidase C (CPC) 0.0711 0.3383 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0128 0.042 0.0206
Echinococcus multilocularis cysteine protease 0.0436 0.1988 0.1988
Plasmodium falciparum serine repeat antigen 7 0.0128 0.042 0.1137
Entamoeba histolytica cysteine protease, putative 0.0253 0.1056 0.473
Onchocerca volvulus 0.0436 0.1988 0.4306
Brugia malayi EF hand family protein 0.0088 0.0219 0.0219
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0436 0.1988 0.1988
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0155 0.0557 0.1071
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.0346
Trypanosoma brucei calpain-like protein, putative 0.0535 0.2489 0.7175
Trypanosoma cruzi centrin, putative 0.0092 0.0237 0.0019
Echinococcus multilocularis calbindin 32 0.009 0.0227 0.0227
Brugia malayi Cathepsin L-like precursor 0.0436 0.1988 0.1988
Trypanosoma cruzi cysteine peptidase, putative 0.0436 0.1988 0.1809
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.1988 0.5593
Loa Loa (eye worm) hypothetical protein 0.0128 0.042 0.042
Echinococcus granulosus cathepsin l1 0.0311 0.1353 0.1353
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.1988 0.5593
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.1988 0.5593
Entamoeba histolytica cysteine protease, putative 0.0128 0.042 0.1137
Trypanosoma cruzi kinesin, putative 0.038 0.17 0.1515
Leishmania major hypothetical protein, unknown function 0.0155 0.0557 0.1071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.1988 0.5593
Plasmodium falciparum serine repeat antigen 3 0.0128 0.042 0.1137
Echinococcus multilocularis calpain 7 (C02 family) 0.0535 0.2489 0.2489
Trypanosoma cruzi centrin-3 0.0092 0.0237 0.0019
Echinococcus granulosus cathepsin L 0.0128 0.042 0.042
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0436 0.1988 0.1988
Schistosoma mansoni calpain-7 (C02 family) 0.0539 0.2507 0.2507
Brugia malayi Cathepsin L-like precursor 0.0436 0.1988 0.1988
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.1071
Leishmania major cathepsin L-like protease 0.0436 0.1988 0.5593
Giardia lamblia Cathepsin L precursor 0.0128 0.042 0.0611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.1988 0.5593
Trypanosoma brucei antigen, putative 0.0535 0.2489 0.7175
Loa Loa (eye worm) hypothetical protein 0.0088 0.0219 0.0219
Echinococcus multilocularis neurocalcin 0.0088 0.0219 0.0219
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0128 0.042 0.0887
Toxoplasma gondii cathepsin CPC1 0.0128 0.042 0.0636
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0128 0.042 0.0636
Leishmania major cathepsin L-like protease 0.0436 0.1988 0.5593
Giardia lamblia Cathepsin B precursor 0.0128 0.042 0.0611
Giardia lamblia Cysteine protease 0.0128 0.042 0.0611
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0128 0.042 0.042
Giardia lamblia Cathepsin L precursor 0.0128 0.042 0.0611
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0535 0.2489 0.2321
Echinococcus granulosus cathepsin l cysteine peptidase 0.0436 0.1988 0.1988
Giardia lamblia Hypothetical protein 0.0128 0.042 0.0611
Echinococcus multilocularis calmodulin 0.0088 0.0219 0.0219
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.1988 0.5593
Echinococcus granulosus calpain 5 0.0535 0.2489 0.2489
Schistosoma mansoni cathepsin D (A01 family) 0.0212 0.0846 0.0846
Entamoeba histolytica cysteine protease, putative 0.0253 0.1056 0.473
Echinococcus multilocularis programmed cell death protein 0.0092 0.0237 0.0237
Echinococcus multilocularis EF hand domain containing family member A2 0.0088 0.0219 0.0219
Toxoplasma gondii calcium-dependent protein kinase 0.009 0.0227 0.0027
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0155 0.0557 0.1071
Loa Loa (eye worm) calpain 5 0.038 0.17 0.17
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0128 0.042 0.0636
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0128 0.042 0.042
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.152 0.7499 0.7499
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0711 0.3383 0.3235
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.1988 0.5593
Echinococcus multilocularis calpain 5 0.0535 0.2489 0.2489
Giardia lamblia Cathepsin L precursor 0.0128 0.042 0.0611
Loa Loa (eye worm) calpain family protein 1 0.1052 0.5117 0.5117
Leishmania major cathepsin L-like protease 0.0436 0.1988 0.5593
Schistosoma mansoni neuronal calcium sensor 0.0088 0.0219 0.0219
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0311 0.1353 0.1159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.1056 0.2646
Plasmodium falciparum serine repeat antigen 2 0.0128 0.042 0.1137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.042 0.0636
Giardia lamblia Cathepsin B precursor 0.0711 0.3383 1
Entamoeba histolytica cysteine proteinase, putative 0.0436 0.1988 1
Brugia malayi Papain family cysteine protease containing protein 0.0253 0.1056 0.1056
Echinococcus granulosus calpain 0.0535 0.2489 0.2489
Trichomonas vaginalis calcineurin B subunit, putative 0.009 0.0227 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0128 0.042 0.0636
Echinococcus multilocularis calmodulin 0.0088 0.0219 0.0219
Entamoeba histolytica cysteine protease, putative 0.0128 0.042 0.1137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0311 0.1353 0.3584
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.042 0.0636
Plasmodium vivax vivapain-1 0.0253 0.1056 0.3687
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0128 0.042 0.042
Loa Loa (eye worm) hypothetical protein 0.0897 0.4329 0.4329
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.1056 0.2646
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0436 0.1988 0.1988
Echinococcus multilocularis cathepsin L 0.0253 0.1056 0.1056
Brugia malayi EF hand family protein 0.009 0.0227 0.0227
Trypanosoma cruzi cysteine protease, putative 0.0253 0.1056 0.0856
Loa Loa (eye worm) programmed cell death protein 6 0.009 0.0227 0.0227
Schistosoma mansoni calmodulin 0.0088 0.0219 0.0219
Entamoeba histolytica cysteine protease, putative 0.0253 0.1056 0.473
Trypanosoma cruzi cysteine peptidase, putative 0.0436 0.1988 0.1809
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0128 0.042 0.042
Plasmodium vivax serine-repeat antigen (SERA) 0.0128 0.042 0.0887
Plasmodium falciparum serine repeat antigen 5 0.0128 0.042 0.1137
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0128 0.042 0.0887
Entamoeba histolytica cysteine protease, putative 0.0128 0.042 0.1137
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.1988 0.5593
Echinococcus granulosus cysteine protease 0.0253 0.1056 0.1056
Echinococcus granulosus cathepsin L 0.0253 0.1056 0.1056
Onchocerca volvulus 0.0897 0.4329 1
Giardia lamblia Cathepsin B precursor 0.0711 0.3383 1
Echinococcus granulosus gamma secretase subunit aph 1 0.0245 0.1015 0.1015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.1988 0.5593
Echinococcus granulosus neuronal calcium sensor 0.0088 0.0219 0.0219
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.1071
Onchocerca volvulus 0.0436 0.1988 0.4306
Schistosoma mansoni neuronal calcium sensor 0.0088 0.0219 0.0219
Schistosoma mansoni cathepsin C 0.0128 0.042 0.042
Entamoeba histolytica cysteine protease, putative 0.0253 0.1056 0.473
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0155 0.0557 0.0346
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0535 0.2489 0.2321
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.1071
Echinococcus multilocularis calpain 0.0535 0.2489 0.2489
Plasmodium falciparum serine repeat antigen 9 0.0128 0.042 0.1137
Brugia malayi Cathepsin L-like precursor 0.0311 0.1353 0.1353
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.1988 0.5593
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0535 0.2489 0.7175
Trypanosoma cruzi cysteine peptidase, putative 0.0125 0.0405 0.019
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0128 0.042 0.0636
Schistosoma mansoni centrin 0.0088 0.0219 0.0219
Echinococcus granulosus calpain A 0.0535 0.2489 0.2489
Trypanosoma cruzi kinesin, putative 0.038 0.17 0.1515
Entamoeba histolytica cysteine protease, putative 0.0128 0.042 0.1137
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.1056 0.473
Trypanosoma cruzi cysteine peptidase, putative 0.0436 0.1988 0.1809
Trypanosoma cruzi centrin, putative 0.0092 0.0237 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.1988 0.5593
Leishmania major hypothetical protein, conserved 0.009 0.0227 0.0027
Toxoplasma gondii cathepsin CPC2 0.0128 0.042 0.0636
Plasmodium falciparum cysteine proteinase falcipain 1 0.0253 0.1056 0.473
Leishmania major cathepsin L-like protease 0.0436 0.1988 0.5593
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0128 0.042 0.0636
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.1988 0.5593
Schistosoma mansoni calcium binding atopy-related autoantigen 0.009 0.0227 0.0227
Schistosoma mansoni calpain C (C02 family) 0.0535 0.2489 0.2489
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0253 0.1056 0.0856
Entamoeba histolytica cysteine proteinase, putative 0.0436 0.1988 1
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.042 0.0636
Echinococcus granulosus EF HAND 1 calcium binding site 0.0088 0.0219 0.0219
Trichomonas vaginalis calcium binding protein, putative 0.0092 0.0237 0.0057
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0128 0.042 0.042
Schistosoma mansoni calpain (C02 family) 0.0535 0.2489 0.2489
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.1071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.1988 0.5593
Loa Loa (eye worm) hypothetical protein 0.0128 0.042 0.042
Trypanosoma brucei caltractin, putative 0.0092 0.0237 0.0057
Onchocerca volvulus 0.0128 0.042 0.049
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0557 0.1071
Brugia malayi calpain D 0.0155 0.0557 0.0557
Brugia malayi cathepsin Z-like cysteine proteinase 0.0128 0.042 0.042
Leishmania major kinesin, putative 0.038 0.17 0.4683
Trypanosoma brucei cysteine peptidase, putative 0.0155 0.0557 0.1071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.1988 0.5593

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 446.6836 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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