Detailed information for compound 268992

Basic information

Technical information
  • TDR Targets ID: 268992
  • Name: [3-[2-[[3-[2-acetyloxy-3-(benzylamino)-3-oxop ropyl]-1H-indol-2-yl]disulfanyl]-1H-indol-3-y l]-1-(benzylamino)-1-oxopropan-2-yl] acetate
  • MW: 734.883 | Formula: C40H38N4O6S2
  • H donors: 4 H acceptors: 4 LogP: 6.99 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)OC(C(=O)NCc1ccccc1)Cc1c(SSc2[nH]c3c(c2CC(C(=O)NCc2ccccc2)OC(=O)C)cccc3)[nH]c2c1cccc2
  • InChi: 1S/C40H38N4O6S2/c1-25(45)49-35(37(47)41-23-27-13-5-3-6-14-27)21-31-29-17-9-11-19-33(29)43-39(31)51-52-40-32(30-18-10-12-20-34(30)44-40)22-36(50-26(2)46)38(48)42-24-28-15-7-4-8-16-28/h3-20,35-36,43-44H,21-24H2,1-2H3,(H,41,47)(H,42,48)
  • InChiKey: ULJVYCBHZIELSM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1-[[2-[[3-[2-acetoxy-3-(benzylamino)-3-oxo-propyl]-1H-indol-2-yl]disulfanyl]-1H-indol-3-yl]methyl]-2-(benzylamino)-2-oxo-ethyl] acetate
  • acetic acid [1-[[2-[[3-[2-acetoxy-3-(benzylamino)-3-oxopropyl]-1H-indol-2-yl]disulfanyl]-1H-indol-3-yl]methyl]-2-(benzylamino)-2-oxoethyl] ester
  • [3-[2-[[3-[2-acetyloxy-3-oxo-3-(phenylmethylamino)propyl]-1H-indol-2-yl]disulfanyl]-1H-indol-3-yl]-1-oxo-1-(phenylmethylamino)propan-2-yl] ethanoate
  • acetic acid [1-[[2-[[3-[2-acetoxy-3-(benzylamino)-3-keto-propyl]-1H-indol-2-yl]disulfanyl]-1H-indol-3-yl]methyl]-2-(benzylamino)-2-keto-ethyl] ester
  • [3-[2-[[3-[2-acetyloxy-3-oxo-3-(phenylmethylamino)propyl]-1H-indol-2-yl]disulfanyl]-1H-indol-3-yl]-1-oxo-1-(phenylmethylamino)propan-2-yl] acetate
  • [1-[[2-[[3-[2-acetoxy-3-oxo-3-(phenylmethylamino)propyl]-1H-indol-2-yl]disulfanyl]-1H-indol-3-yl]methyl]-2-oxo-2-(phenylmethylamino)ethyl] acetate
  • acetic acid [1-[[2-[[3-[2-acetoxy-3-oxo-3-(phenylmethylamino)propyl]-1H-indol-2-yl]disulfanyl]-1H-indol-3-yl]methyl]-2-oxo-2-(phenylmethylamino)ethyl] ester
  • 1 H-indole-3-alkanamide deriv. 10s

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0208 0.1918 0.1911
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0016 0.0045 0.0036
Trichomonas vaginalis chromobox protein, putative 0.0041 0.029 0.0281
Loa Loa (eye worm) hypothetical protein 0.0208 0.1918 0.1916
Loa Loa (eye worm) hypothetical protein 0.0861 0.8293 0.8293
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0065 0.0525 0.0517
Brugia malayi Cathepsin L-like precursor 0.1036 1 1
Echinococcus multilocularis neurocalcin 0.0012 0.0009 0.0009
Schistosoma mansoni chromatin regulatory protein sir2 0.0065 0.0525 0.0517
Leishmania major hypothetical protein, conserved 0.003 0.0185 0.0176
Schistosoma mansoni Mername-AA248 (C02 family) 0.01 0.0867 0.0859
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0181 0.0181
Plasmodium vivax unspecified product 0.0208 0.1918 0.1911
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0016 0.0045 0.0036
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0208 0.1918 0.1911
Loa Loa (eye worm) cathepsin B 0.041 0.389 0.3888
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1036 1 1
Trypanosoma cruzi kinesin, putative 0.007 0.0574 0.0565
Brugia malayi Thioredoxin family protein 0.0108 0.095 0.0948
Leishmania major kinesin, putative 0.007 0.0574 0.0565
Entamoeba histolytica cysteine proteinase, putative 0.0544 0.5195 0.519
Giardia lamblia Hypothetical protein 0.0208 0.1918 0.4919
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0252 0.2355 0.2348
Giardia lamblia Transglutaminase/protease, putative 0.0108 0.095 0.2425
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0183 0.1675 0.1673
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0467 0.0467
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0016 0.0045 0.0042
Giardia lamblia 20S proteasome alpha subunit 4 0.0016 0.0045 0.0092
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0065 0.0525 0.0525
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0016 0.0045 0.0036
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0551 0.0549
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.1675 0.1667
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.003 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0544 0.5195 0.519
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0065 0.0525 0.0517
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.003 0.0185 0.0176
Plasmodium vivax calpain, putative 0.01 0.0867 0.0859
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.003 0.0185 0.0176
Trypanosoma brucei proteasome alpha 7 subunit 0.0016 0.0045 0.0036
Brugia malayi cathepsin F-like cysteine proteinase 0.0336 0.3168 0.3167
Loa Loa (eye worm) hypothetical protein 0.0214 0.1984 0.1982
Brugia malayi Proteasome A-type and B-type family protein 0.0016 0.0045 0.0042
Echinococcus granulosus GPCR family 2 0.0032 0.02 0.02
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0016 0.0045 0.0036
Plasmodium falciparum serine repeat antigen 7 0.0208 0.1918 0.1911
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0279 0.2617 0.2617
Giardia lamblia 20S proteasome alpha subunit 6 0.0016 0.0045 0.0092
Schistosoma mansoni calpain-2 (C02 family) 0.003 0.0185 0.0176
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.041 0.389 0.3884
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.01 0.0867 0.0859
Loa Loa (eye worm) hypothetical protein 0.0053 0.041 0.0408
Echinococcus granulosus calpain 7 C02 family 0.01 0.0867 0.0867
Trypanosoma brucei calpain-like protein, putative 0.01 0.0867 0.0859
Schistosoma mansoni cathepsin F (C01 family) 0.07 0.6724 0.6721
Toxoplasma gondii proteasome beta subunit 0.0016 0.0045 0.0036
Brugia malayi Calmodulin-like protein 0.0012 0.0009 0.0007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0467 0.4665
Echinococcus multilocularis lamin 0.0028 0.0164 0.0164
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0062 0.0496 0.0487
Onchocerca volvulus Cathepsin F homolog 0.1036 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0208 0.1918 0.4919
Onchocerca volvulus 0.0047 0.0349 0.0349
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0016 0.0045 0.0036
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.01 0.0867 0.0859
Schistosoma mansoni tar DNA-binding protein 0.0064 0.052 0.0512
Entamoeba histolytica cysteine protease, putative 0.0544 0.5195 0.519
Giardia lamblia Cathepsin B precursor 0.0208 0.1918 0.4919
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0252 0.2355 0.2355
Giardia lamblia Hypothetical protein 0.0108 0.095 0.2425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1036 1 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.041 0.389 0.3884
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.02 0.02
Brugia malayi Cathepsin L-like precursor 0.07 0.6724 0.6723
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0017 0.0017
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0016 0.0045 0.0036
Echinococcus granulosus proteasome subunit alpha type 6 0.0016 0.0045 0.0045
Loa Loa (eye worm) proteasome subunit beta type 2 0.0038 0.0266 0.0264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1036 1 1
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.003 0.0185 0.0176
Entamoeba histolytica cysteine protease, putative 0.0544 0.5195 0.519
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0279 0.2617 0.2617
Echinococcus granulosus EF hand domain containing family member A2 0.0012 0.0009 0.0009
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.008 0.0669 0.0661
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0208 0.1918 0.1911
Loa Loa (eye worm) hypothetical protein 0.07 0.6724 0.6723
Toxoplasma gondii hypothetical protein 0.003 0.0185 0.0176
Leishmania major proteasome beta 2 subunit, putative 0.0038 0.0266 0.0257
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0208 0.1918 0.1911
Giardia lamblia Cysteine protease 0.0208 0.1918 0.4919
Trypanosoma cruzi cysteine peptidase, putative 0.1036 1 1
Loa Loa (eye worm) programmed cell death protein 6 0.0012 0.0009 0.0007
Onchocerca volvulus 0.0012 0.0009 0.0009
Giardia lamblia Cysteine protease 0.0208 0.1918 0.4919
Leishmania major calpain family cysteine protease-like protein 0.003 0.0185 0.0176
Entamoeba histolytica cysteine proteinase, putative 0.07 0.6724 0.6721
Brugia malayi calcium-binding protein 0.0012 0.0009 0.0007
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0016 0.0045 0.0036
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0016 0.0045 0.0045
Mycobacterium tuberculosis Long conserved protein 0.0108 0.095 1
Trypanosoma cruzi cysteine peptidase, putative 0.0544 0.5195 0.519
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1036 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0861 0.8293 0.8292
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.003 0.0185 0.0176
Trypanosoma brucei proteasome subunit beta type-5, putative 0.008 0.0669 0.0661
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1036 1 1
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0016 0.0045 0.0036
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0861 0.8293 0.8292
Plasmodium vivax proteasome subunit beta type-3, putative 0.0016 0.0045 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0208 0.1918 0.1911
Loa Loa (eye worm) hypothetical protein 0.07 0.6724 0.6723
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0065 0.0525 0.0517
Echinococcus multilocularis cathepsin L 0.0208 0.1918 0.1918
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0016 0.0045 0.0036
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0038 0.0266 0.0257
Echinococcus multilocularis cathepsin L cysteine protease 0.1036 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0181 0.0172
Schistosoma mansoni hypothetical protein 0.0032 0.02 0.0191
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0016 0.0045 0.0036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.1675 0.1675
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0066 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1036 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0066 0.0057
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.003 0.0185 0.0176
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0164 0.0162
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0349 0.0347
Brugia malayi Proteasome A-type and B-type family protein 0.0016 0.0045 0.0042
Brugia malayi Heterochromatin protein 1 0.0068 0.0551 0.0549
Echinococcus granulosus proteasome subunit beta t family 0.0016 0.0045 0.0045
Brugia malayi SET domain containing protein 0.0013 0.0017 0.0014
Echinococcus multilocularis EF hand domain containing family member A2 0.0012 0.0009 0.0009
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0062 0.0496 0.0487
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1036 1 1
Echinococcus granulosus intermediate filament protein 0.0028 0.0164 0.0164
Brugia malayi proteasome subunit alpha type 1 0.0016 0.0045 0.0042
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.003 0.0185 0.0176
Loa Loa (eye worm) hypothetical protein 0.0208 0.1918 0.1916
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0016 0.0045 0.0036
Echinococcus multilocularis lamin dm0 0.0028 0.0164 0.0164
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0016 0.0045 0.0036
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0065 0.0525 0.0517
Schistosoma mansoni calpain-7 (C02 family) 0.01 0.0867 0.0859
Echinococcus multilocularis calbindin 32 0.0012 0.0009 0.0009
Echinococcus granulosus cathepsin L cysteine protease 0.0544 0.5195 0.5195
Giardia lamblia Cysteine protease 0.0208 0.1918 0.4919
Entamoeba histolytica cysteine protease, putative 0.0208 0.1918 0.1911
Entamoeba histolytica cysteine proteinase, putative 0.0544 0.5195 0.519
Leishmania major cathepsin L-like protease 0.1036 1 1
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0016 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1036 1 1
Loa Loa (eye worm) PAS-3 protein 0.0016 0.0045 0.0042
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0277 0.2593 0.2587
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0062 0.0496 0.0496
Echinococcus granulosus calpain 0.01 0.0867 0.0867
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0016 0.0045 0.0036
Plasmodium vivax unspecified product 0.0336 0.3168 0.3162
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0065 0.0525 0.0525
Loa Loa (eye worm) cysteine protease 0.1036 1 1
Echinococcus multilocularis programmed cell death protein 0.0012 0.0009 0.0009
Mycobacterium ulcerans hypothetical protein 0.0108 0.095 1
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0557 0.0555
Loa Loa (eye worm) hypothetical protein 0.0265 0.2476 0.2475
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1036 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0864 0.0862
Leishmania major cysteine peptidase A (CPA) 0.1036 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0262 0.0259
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0066 0.0057
Plasmodium falciparum cysteine proteinase falcipain 1 0.0544 0.5195 0.519
Brugia malayi 20S proteasome alpha5 subunit 0.0016 0.0045 0.0042
Mycobacterium ulcerans NAD-dependent deacetylase 0.0065 0.0525 0.5308
Giardia lamblia Cathepsin B precursor 0.041 0.389 1
Echinococcus multilocularis chromobox protein 1 0.0068 0.0551 0.0551
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0525 0.0517
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1036 1 1
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0016 0.0045 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0208 0.1918 0.1911
Brugia malayi NAD-dependent deacetylase SIRT1 0.0279 0.2617 0.2615
Giardia lamblia Sirtuin type 2 0.0065 0.0525 0.133
Entamoeba histolytica cysteine proteinase, putative 0.0544 0.5195 0.519
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0183 0.1675 0.1673
Entamoeba histolytica cysteine protease, putative 0.0208 0.1918 0.1911
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.052 0.0518
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1036 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0208 0.1918 0.1911
Toxoplasma gondii cathepsin B 0.041 0.389 0.3884
Leishmania major proteasome beta 7 subunit, putative 0.0016 0.0045 0.0036
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0016
Echinococcus multilocularis musashi 0.0028 0.0164 0.0164
Echinococcus granulosus geminin 0.0164 0.1496 0.1496
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.1675 0.1667
Loa Loa (eye worm) hypothetical protein 0.0032 0.02 0.0197
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.003 0.0185 0.0176
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0016 0.0045 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1036 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1036 1 1
Entamoeba histolytica cysteine protease, putative 0.0544 0.5195 0.519
Brugia malayi transcriptional regulator, Sir2 family protein 0.0065 0.0525 0.0523
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1036 1 1
Echinococcus multilocularis calpain A 0.0277 0.2593 0.2593
Loa Loa (eye worm) hypothetical protein 0.0028 0.0164 0.0162
Entamoeba histolytica cysteine protease, putative 0.0208 0.1918 0.1911
Plasmodium vivax serine-repeat antigen (SERA) 0.0208 0.1918 0.1911
Leishmania major cathepsin L-like protease 0.1036 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0861 0.8293 0.8292
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0016 0.0045 0.0036
Loa Loa (eye worm) proteasome subunit beta type 1 0.0062 0.0496 0.0494
Giardia lamblia Cathepsin L precursor 0.0208 0.1918 0.4919
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0208 0.1918 0.1911
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0016 0.0045 0.0036
Mycobacterium tuberculosis Conserved hypothetical protein 0.0108 0.095 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0208 0.1918 0.4919
Plasmodium vivax vivapain-2 0.1036 1 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0279 0.2617 0.261
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.008 0.0669 0.0661
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.003 0.0185 0.0176
Schistosoma mansoni hypothetical protein 0.0068 0.0557 0.0548
Plasmodium falciparum cysteine proteinase falcipain 3 0.1036 1 1
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0016 0.0045 0.0036
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.02 0.02
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.01 0.0867 0.0859
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0016 0.0045 0.0036
Toxoplasma gondii cathepsin CPC2 0.0208 0.1918 0.1911
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0208 0.1918 0.1911
Trypanosoma cruzi cruzipain precursor, putative 0.1036 1 1
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2142 0.2135
Schistosoma mansoni intermediate filament proteins 0.0028 0.0164 0.0155
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Entamoeba histolytica cysteine proteinase 2 0.0544 0.5195 0.519
Toxoplasma gondii histone deacetylase SIR2-like 0.0065 0.0525 0.0517
Echinococcus granulosus cpg binding protein 0.0031 0.0198 0.0198
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0016 0.0045 0.0036
Giardia lamblia 20S proteasome alpha subunit 7 0.0016 0.0045 0.0092
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Onchocerca volvulus 0.0231 0.2144 0.2144
Loa Loa (eye worm) fibroinase 0.1036 1 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0208 0.1918 0.1911
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0277 0.2593 0.2593
Trypanosoma brucei calpain, putative 0.003 0.0185 0.0176
Plasmodium vivax SET domain protein, putative 0.003 0.0181 0.0172
Entamoeba histolytica cysteine proteinase 1, putative 0.0544 0.5195 0.519
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0016 0.0045 0.0036
Loa Loa (eye worm) ctsf protein 0.1036 1 1
Trypanosoma brucei Calpain-like protein 2 0.003 0.0185 0.0176
Brugia malayi Proteasome A-type and B-type family protein 0.008 0.0669 0.0667
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0066 0.0057
Echinococcus multilocularis centrin 2 0.0012 0.0009 0.0009
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Echinococcus granulosus chromobox protein 1 0.0068 0.0551 0.0551
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0016 0.0045 0.0036
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0038 0.0035
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0062 0.0496 0.0487
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0023 0.0023
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0017 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0181 0.0172
Trichomonas vaginalis calpain, putative 0.003 0.0185 0.0176
Echinococcus granulosus cathepsin l1 0.07 0.6724 0.6724
Mycobacterium ulcerans Sir2-like regulatory protein 0.0065 0.0525 0.5308
Echinococcus granulosus chromatin regulatory protein sir2 0.0252 0.2355 0.2355
Schistosoma mansoni cathepsin F (C01 family) 0.1036 1 1
Echinococcus granulosus Proteasome subunit alpha type 7 0.0016 0.0045 0.0045
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.041 0.389 0.3884
Brugia malayi Cathepsin L-like precursor 0.1036 1 1
Echinococcus granulosus calbindin 32 0.0012 0.0009 0.0009
Mycobacterium tuberculosis Conserved hypothetical protein 0.0108 0.095 1
Brugia malayi Papain family cysteine protease containing protein 0.1036 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0544 0.5195 0.519
Echinococcus multilocularis GPCR, family 2 0.0032 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.003 0.0181 0.0179
Onchocerca volvulus 0.0012 0.0009 0.0009
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Echinococcus granulosus EF hand domain containing family member A2 0.0012 0.0009 0.0009
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0038 0.0266 0.0257
Giardia lamblia Cathepsin B precursor 0.041 0.389 1
Leishmania major calpain protease-like protein 0.003 0.0185 0.0176
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.003 0.0185 0.0176
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1036 1 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.01 0.0867 0.0859
Brugia malayi Cathepsin L-like precursor 0.07 0.6724 0.6723
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0016 0.0045 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.1918 0.1911
Trypanosoma brucei calpain, putative 0.003 0.0185 0.0176
Trypanosoma cruzi conserved protein 0.003 0.0185 0.0176
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0208 0.1918 0.1911
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0467 0.4665
Trypanosoma brucei proteasome beta 7 subunit 0.0016 0.0045 0.0036
Echinococcus granulosus lamin dm0 0.0028 0.0164 0.0164
Brugia malayi Papain family cysteine protease containing protein 0.0208 0.1918 0.1916
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0181 0.0181
Mycobacterium ulcerans transglutaminase family protein 0.0108 0.095 1
Onchocerca volvulus 0.1036 1 1
Entamoeba histolytica hypothetical protein, conserved 0.0065 0.0525 0.0517
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0208 0.1918 0.1911
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.01 0.0867 0.0859
Echinococcus multilocularis proteasome subunit beta type 6 0.0016 0.0045 0.0045
Entamoeba histolytica cysteine protease, putative 0.0544 0.5195 0.519
Leishmania major proteasome alpha 1 subunit, putative 0.0016 0.0045 0.0036
Entamoeba histolytica cysteine protease, putative 0.0544 0.5195 0.519
Loa Loa (eye worm) hypothetical protein 0.0336 0.3168 0.3167
Giardia lamblia Proteasome subunit beta type 3 0.0016 0.0045 0.0092
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0016
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0864 0.0862
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0016 0.0045 0.0036
Brugia malayi programmed cell death protein 6 0.0012 0.0009 0.0007
Plasmodium vivax proteasome subunit beta type-4, putative 0.0016 0.0045 0.0036
Echinococcus granulosus cathepsin b 0.0861 0.8293 0.8293
Giardia lamblia Proteasome subunit beta type 5 precursor 0.008 0.0669 0.1701
Leishmania major hypothetical protein, unknown function 0.003 0.0185 0.0176
Echinococcus multilocularis EF hand domain containing family member A2 0.0012 0.0009 0.0009
Echinococcus multilocularis Transglutaminase 0.0108 0.095 0.095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1036 1 1
Schistosoma mansoni chromobox protein 0.0068 0.0551 0.0543
Loa Loa (eye worm) transcriptional regulator 0.0065 0.0525 0.0523
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0262 0.0262
Entamoeba histolytica cysteine proteinase, putative 0.1036 1 1
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0016 0.0045 0.0036
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0252 0.2355 0.2355
Trypanosoma cruzi calpain cysteine peptidase, putative 0.01 0.0867 0.0859
Plasmodium vivax vivapain-2 0.1036 1 1
Echinococcus multilocularis neuronal calcium sensor 0.0012 0.0009 0.0009
Schistosoma mansoni inhibitor of apoptosis protein 0.0053 0.041 0.0401
Schistosoma mansoni hypothetical protein 0.0108 0.095 0.0942
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0065 0.0525 0.0517
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0252 0.2355 0.2348
Brugia malayi calpain D 0.003 0.0185 0.0183
Brugia malayi Papain family cysteine protease containing protein 0.0544 0.5195 0.5193
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0544 0.5195 0.519
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0517 0.0508
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0035 0.0026
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0007
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0208 0.1918 0.1916
Trypanosoma cruzi cysteine peptidase, putative 0.1036 1 1
Plasmodium falciparum proteasome subunit beta type-5 0.008 0.0669 0.0661
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0016 0.0045 0.0045
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0065 0.0525 0.0517
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0016 0.0045 0.0036
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0016 0.0045 0.0036
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0016 0.0045 0.0036
Schistosoma mansoni hypothetical protein 0.0047 0.0349 0.034
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.01 0.0867 0.0859
Leishmania major proteasome alpha 1 subunit, putative 0.0016 0.0045 0.0036
Onchocerca volvulus 0.1036 1 1
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0016 0.0045 0.0036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0208 0.1918 0.1911
Entamoeba histolytica cysteine protease, putative 0.0208 0.1918 0.1911
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.003 0.0185 0.0176
Brugia malayi calpain 7 0.01 0.0867 0.0865
Schistosoma mansoni cpg binding protein 0.0031 0.0198 0.0189
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0181 0.0172
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Trypanosoma brucei kinesin, putative 0.007 0.0574 0.0565
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0062 0.0496 0.0487
Trypanosoma brucei Calpain-like protein CALP1.3 0.003 0.0185 0.0176
Schistosoma mansoni cathepsin C 0.0208 0.1918 0.1911
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0016 0.0045 0.0036
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0208 0.1918 0.1911
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.008 0.0669 0.0661
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1036 1 1
Trypanosoma brucei proteasome beta 6 subunit 0.0062 0.0496 0.0487
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1036 1 1
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0016 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.003 0.0185 0.0176
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0062 0.0496 0.0487
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0208 0.1918 0.1911
Brugia malayi EF hand family protein 0.0012 0.0009 0.0007
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0208 0.1918 0.1911
Mycobacterium leprae Conserved hypothetical protein 0.0108 0.095 1
Echinococcus multilocularis chromatin regulatory protein sir2 0.0252 0.2355 0.2355
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0016 0.0045 0.0036
Echinococcus granulosus calmodulin 0.0012 0.0009 0.0009
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0016 0.0045 0.0042
Echinococcus granulosus calumenin 0.0012 0.0009 0.0009
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0336 0.3168 0.3167
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.003 0.0185 0.0176
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0016 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.0235 0.2183 0.2182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0544 0.5195 0.519
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0016 0.0045 0.0036
Giardia lamblia Proteasome subunit beta type 2 0.0038 0.0266 0.0663
Onchocerca volvulus 0.0165 0.1502 0.1502
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1022 0.102
Brugia malayi Pre-SET motif family protein 0.0203 0.1869 0.1868
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0016 0.0045 0.0036
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0016 0.0045 0.0036
Echinococcus granulosus proteasome subunit beta type 6 0.0016 0.0045 0.0045
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0208 0.1918 0.1911
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0016 0.0045 0.0042
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0038 0.0266 0.0257
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0016 0.0045 0.0036
Echinococcus granulosus proteasome prosome macropain 0.008 0.0669 0.0669
Brugia malayi calpain family protein 1 0.0265 0.2476 0.2475
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0016 0.0045 0.0036
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Plasmodium vivax vivapain-1 0.0544 0.5195 0.519
Trypanosoma cruzi cruzipain precursor, putative 0.0336 0.3168 0.3162
Giardia lamblia Cathepsin L precursor 0.0208 0.1918 0.4919
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0016 0.0045 0.0092
Loa Loa (eye worm) hypothetical protein 0.0279 0.2617 0.2615
Brugia malayi transcriptional regulator, Sir2 family protein 0.0252 0.2355 0.2353
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0208 0.1918 0.1911
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0279 0.2617 0.261
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0053 0.041 0.041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1036 1 1
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0016 0.0045 0.0036
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0053 0.041 0.0408
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0016 0.0045 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0262 0.0253
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0861 0.8293 0.8292
Entamoeba histolytica calpain large subunit domain III containing protein 0.007 0.0574 0.0565
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1036 1 1
Trichomonas vaginalis calpain, putative 0.003 0.0185 0.0176
Plasmodium vivax proteasome subunit beta type-6, putative 0.0016 0.0045 0.0036
Trichomonas vaginalis peptide N-glycanase, putative 0.0108 0.095 0.0942
Trypanosoma brucei SIR2-like protein 4, putative 0.0065 0.0525 0.0517
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0208 0.1918 0.1911
Toxoplasma gondii proteasome subunit beta type, putative 0.008 0.0669 0.0661
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0016 0.0045 0.0036
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0016 0.0045 0.0036
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0016 0.0045 0.0036
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0016 0.0045 0.0036
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0181 0.0181
Echinococcus granulosus calpain A 0.0277 0.2593 0.2593
Echinococcus multilocularis calpain family protein 1, d 0.0195 0.1795 0.1795
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1036 1 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.052 0.0512
Schistosoma mansoni chromatin regulatory protein sir2 0.0065 0.0525 0.0517
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0467 0.4665
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0016 0.0045 0.0036
Giardia lamblia Cathepsin L-like protease 0.0208 0.1918 0.4919
Plasmodium vivax serine-repeat antigen (SERA) 0.0208 0.1918 0.1911
Loa Loa (eye worm) calpain family protein 1 0.0195 0.1795 0.1793
Onchocerca volvulus 0.1036 1 1
Giardia lamblia Cathepsin B precursor 0.0208 0.1918 0.4919
Leishmania major proteasome alpha 2 subunit, putative 0.0016 0.0045 0.0036
Echinococcus granulosus chromobox protein 1 0.0068 0.0551 0.0551
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.01 0.0867 0.0859
Schistosoma mansoni chromatin regulatory protein sir2 0.0252 0.2355 0.2348
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1036 1 1
Echinococcus multilocularis tar DNA binding protein 0.0064 0.052 0.052
Giardia lamblia Cathepsin L precursor 0.0208 0.1918 0.4919
Schistosoma mansoni hypothetical protein 0.0423 0.4016 0.401
Loa Loa (eye worm) hypothetical protein 0.01 0.0864 0.0862
Schistosoma mansoni calpain (C02 family) 0.01 0.0867 0.0859
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Brugia malayi Cathepsin L-like precursor 0.1036 1 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.041 0.0408
Echinococcus granulosus proteasome subunit beta type 7 0.0016 0.0045 0.0045
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0208 0.1918 0.1916
Echinococcus multilocularis cathepsin L cysteine protease 0.1036 1 1
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0065 0.0525 0.5308
Leishmania major cathepsin L-like protease 0.1036 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1869 0.1868
Plasmodium falciparum serine repeat antigen 5 0.0208 0.1918 0.1911
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0208 0.1918 0.1916
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0016 0.0045 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0208 0.1918 0.1911
Giardia lamblia Cathepsin L precursor 0.0208 0.1918 0.4919
Brugia malayi Papain family cysteine protease containing protein 0.0208 0.1918 0.1916
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.1675 0.1675
Entamoeba histolytica cysteine protease, putative 0.0544 0.5195 0.519
Schistosoma mansoni cpg binding protein 0.003 0.0182 0.0173
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0016 0.0045 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1036 1 1
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0016 0.0045 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Loa Loa (eye worm) RNA binding protein 0.0064 0.052 0.0518
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0016 0.0045 0.0036
Entamoeba histolytica hypothetical protein 0.0208 0.1918 0.1911
Onchocerca volvulus 0.0028 0.0164 0.0164
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0016 0.0045 0.0036
Brugia malayi MH2 domain containing protein 0.0116 0.1022 0.102
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0016 0.0045 0.0036
Loa Loa (eye worm) sirtuin 4 0.0065 0.0525 0.0523
Brugia malayi cathepsin L precursor 0.0208 0.1918 0.1916
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0451 0.0442
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.01 0.0867 0.0859
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1036 1 1
Onchocerca volvulus Cathepsin L homolog 0.0208 0.1918 0.1918
Plasmodium falciparum serine repeat antigen 6 0.0208 0.1918 0.1911
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0208 0.1918 0.1911
Echinococcus multilocularis calpain 5 0.01 0.0867 0.0867
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1036 1 1
Loa Loa (eye worm) hypothetical protein 0.0208 0.1918 0.1916
Toxoplasma gondii proteasome subunit 0.0016 0.0045 0.0036
Trypanosoma cruzi major cysteine proteinase, putative 0.0208 0.1918 0.1911
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1036 1 1
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0016 0.0045 0.0036
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0252 0.2355 0.2348
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.003 0.0185 0.0176
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0016 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0208 0.1918 0.1911
Giardia lamblia 20S proteasome alpha subunit 3 0.0016 0.0045 0.0092
Toxoplasma gondii cathepsin CPL 0.1036 1 1
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0016 0.0045 0.0036
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0016 0.0045 0.0036
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.2132 0.2132
Loa Loa (eye worm) hypothetical protein 0.1036 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1036 1 1
Giardia lamblia Cathepsin B precursor 0.0208 0.1918 0.4919
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0012 0.0009 0.0009
Loa Loa (eye worm) proteasome subunit beta type 3 0.0016 0.0045 0.0042
Echinococcus multilocularis proteasome (prosome, macropain) 0.008 0.0669 0.0669
Onchocerca volvulus 0.0282 0.2647 0.2647
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1036 1 1
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0038 0.0266 0.0266
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0016 0.0045 0.0036
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0016 0.0045 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0185 0.0176
Plasmodium vivax NAD-dependent deacetylase, putative 0.0065 0.0525 0.0517
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0544 0.5195 0.519
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0208 0.1918 0.1911
Mycobacterium leprae proteasome (beta subunit) PrcB 0.008 0.0669 0.6899
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0208 0.1918 0.1911
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.041 0.389 0.3884
Echinococcus granulosus cathepsin l cysteine peptidase 0.1036 1 1
Echinococcus granulosus programmed cell death protein 0.0012 0.0009 0.0009
Leishmania major proteasome beta 3 subunit, putative 0.0016 0.0045 0.0036
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0016 0.0045 0.0036
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0279 0.2617 0.672
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0016 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1036 1 1
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0016 0.0045 0.0036
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0016 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0208 0.1918 0.1916
Echinococcus granulosus proteasome subunit alpha type 2 0.0016 0.0045 0.0045
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0164 0.0164
Schistosoma mansoni hypothetical protein 0.0032 0.02 0.0191
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0016 0.0045 0.0036
Onchocerca volvulus 0.003 0.0182 0.0182
Entamoeba histolytica cysteine protease, putative 0.1036 1 1
Plasmodium vivax proteasome subunit beta type-1, putative 0.0062 0.0496 0.0487
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0016 0.0045 0.0036
Brugia malayi RNA binding protein 0.0064 0.052 0.0518
Brugia malayi proteasome subunit beta type 2 0.0038 0.0266 0.0264
Echinococcus multilocularis calmodulin 0.0012 0.0009 0.0009
Trypanosoma cruzi 20S proteasome subunit 0.0038 0.0266 0.0257
Mycobacterium ulcerans hypothetical protein 0.0108 0.095 1
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0038 0.0035
Echinococcus granulosus dnaJ subfamily B 0.0423 0.4016 0.4016
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0038 0.0266 0.0257
Brugia malayi Proteasome subunit alpha type 1 0.0016 0.0045 0.0042
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0016 0.0045 0.0036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0066 0.0057
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0016 0.0045 0.0036
Plasmodium vivax proteasome subunit beta type-5, putative 0.008 0.0669 0.0661
Brugia malayi cathepsin B-like cysteine proteinase 0.0861 0.8293 0.8293
Brugia malayi calpain 5 0.007 0.0574 0.0572
Onchocerca volvulus Cathepsin L homolog 0.1036 1 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0016 0.0045 0.0036
Entamoeba histolytica cysteine proteinase, putative 0.0544 0.5195 0.519
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.02 0.0197
Plasmodium falciparum serine repeat antigen 3 0.0208 0.1918 0.1911
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.07 0.6724 0.6721
Trypanosoma cruzi cysteine peptidase, putative 0.0336 0.3168 0.3162
Echinococcus granulosus centrin 2 0.0012 0.0009 0.0009
Schistosoma mansoni chromatin regulatory protein sir2 0.0279 0.2617 0.261
Leishmania major proteasome beta-1 subunit, putative 0.0016 0.0045 0.0036
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0065 0.0525 0.0517
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0016 0.0045 0.0036
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.008 0.0669 0.0661
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0016 0.0045 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.1675 0.1667
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Leishmania major cathepsin L-like protease 0.1036 1 1
Giardia lamblia Cathepsin L precursor 0.0208 0.1918 0.4919
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.041 0.389 0.3884
Echinococcus granulosus cathepsin l1 0.1036 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1036 1 1
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0065 0.0525 0.0517
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0208 0.1918 0.1911
Echinococcus multilocularis geminin 0.0164 0.1496 0.1496
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.07 0.6724 0.6721
Brugia malayi Papain family cysteine protease containing protein 0.0208 0.1918 0.1916
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0864 0.0862
Echinococcus multilocularis programmed cell death protein 0.0012 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0053 0.041 0.0401
Toxoplasma gondii histone deacetylase SIR2 0.0065 0.0525 0.0517
Echinococcus granulosus neurocalcin 0.0012 0.0009 0.0009
Trichomonas vaginalis hypothetical protein 0.003 0.0185 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0154 0.0145
Loa Loa (eye worm) hypothetical protein 0.023 0.2132 0.213
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.01 0.0867 0.0859
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0208 0.1918 0.1911
Entamoeba histolytica calpain family cysteine protease, putative 0.003 0.0185 0.0176
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.02 0.0197
Echinococcus granulosus calpain 5 0.01 0.0867 0.0867
Echinococcus granulosus cathepsin L cysteine proteinase 0.1036 1 1
Brugia malayi CHD4 protein 0.0013 0.0017 0.0014
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0016 0.0045 0.0036
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0208 0.1918 0.4919
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0016 0.0045 0.0036
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.003 0.0185 0.0176
Giardia lamblia 20S proteasome alpha subunit 1 0.0016 0.0045 0.0092
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0181 0.0172
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0016 0.0045 0.0036
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0012 0.0009 0.0009
Echinococcus multilocularis calcium uptake protein 1 0.0012 0.0009 0.0009
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0065 0.0525 0.0517
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0279 0.2617 0.261
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0016 0.0045 0.0036
Echinococcus granulosus cysteine protease 0.0544 0.5195 0.5195
Leishmania major cathepsin L-like protease 0.1036 1 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0252 0.2355 0.2348
Brugia malayi calpain family protein 1 0.0265 0.2476 0.2475
Loa Loa (eye worm) calpain family protein 1 0.0265 0.2476 0.2475
Echinococcus granulosus Transglutaminase 0.0108 0.095 0.095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0208 0.1918 0.1911
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1036 1 1
Echinococcus granulosus cathepsin b 0.0861 0.8293 0.8293
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0016 0.0045 0.0036
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1036 1 1
Loa Loa (eye worm) hypothetical protein 0.0208 0.1918 0.1916
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0016 0.0045 0.0045
Trichomonas vaginalis calpain, putative 0.003 0.0185 0.0176
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0265 0.2476 0.247
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0016 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.003 0.0185 0.0183
Schistosoma mansoni cpg binding protein 0.0031 0.0198 0.0189
Brugia malayi Cathepsin L-like precursor 0.1036 1 1
Echinococcus granulosus calcium uptake protein 1 0.0012 0.0009 0.0009
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0016 0.0045 0.0036
Leishmania major proteasome beta 2 subunit, putative 0.0016 0.0045 0.0036
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0467 0.0467
Leishmania major proteasome beta 5 subunit, putative 0.008 0.0669 0.0661
Mycobacterium tuberculosis Conserved protein 0.0108 0.095 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0154 0.0145
Entamoeba histolytica cysteine protease, putative 0.0544 0.5195 0.519
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1036 1 1
Leishmania major proteasome alpha 7 subunit, putative 0.0016 0.0045 0.0036
Onchocerca volvulus Notchless protein homolog 0.0016 0.0045 0.0045
Echinococcus multilocularis calpain 7 (C02 family) 0.01 0.0867 0.0867
Trypanosoma brucei antigen, putative 0.01 0.0867 0.0859
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0016 0.0045 0.0036
Mycobacterium ulcerans putative transglutaminase-like protein 0.0108 0.095 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0016 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.0336 0.3168 0.3167
Loa Loa (eye worm) transcriptional regulator 0.0252 0.2355 0.2353
Loa Loa (eye worm) EF hand family protein 0.0012 0.0009 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0208 0.1918 0.1911
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0017 0.0007
Giardia lamblia Transcriptional regulator, Sir2 family 0.0065 0.0525 0.133
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.008 0.0669 0.6899
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0016 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0007
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0016 0.0045 0.0036
Entamoeba histolytica cysteine protease, putative 0.0208 0.1918 0.1911
Plasmodium vivax vivapain-3 0.0544 0.5195 0.519
Plasmodium falciparum serine repeat antigen 1 0.0208 0.1918 0.1911
Schistosoma mansoni cathepsin F (C01 family) 0.1036 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0157
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0053 0.041 0.0401
Echinococcus multilocularis inhibitor of apoptosis protein 0.0053 0.041 0.041
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0208 0.1918 0.1911
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0021
Loa Loa (eye worm) calpain 5 0.007 0.0574 0.0572
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0066 0.0057
Brugia malayi proteasome subunit alpha type 2 0.0016 0.0045 0.0042
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0277 0.2593 0.2593
Entamoeba histolytica cysteine protease, putative 0.0208 0.1918 0.1911
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0544 0.5195 0.519
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0016 0.0045 0.0036
Trypanosoma brucei calpain-like protein, putative 0.01 0.0867 0.0859
Entamoeba histolytica cysteine protease, putative 0.0544 0.5195 0.519
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0544 0.5195 0.519
Schistosoma mansoni survival motor neuron protein 0.0047 0.0349 0.034
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0065 0.0525 0.0517
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.01 0.0867 0.0859
Trypanosoma cruzi cysteine proteinase, putative 0.0544 0.5195 0.519
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0016 0.0045 0.0036
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0467 0.0458
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0016 0.0045 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0035 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1036 1 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0252 0.2355 0.2348
Brugia malayi Papain family cysteine protease containing protein 0.0544 0.5195 0.5193
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0016 0.0045 0.0092
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Loa Loa (eye worm) hypothetical protein 0.0165 0.1502 0.15
Echinococcus multilocularis cpg binding protein 0.0031 0.0198 0.0198
Schistosoma mansoni hypothetical protein 0.0164 0.1496 0.1488
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0467 0.0458
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0065 0.0525 0.0517
Brugia malayi Cathepsin L-like cysteine proteinase 0.07 0.6724 0.6723
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0544 0.5195 0.519
Brugia malayi fibroinase precursor 0.0208 0.1918 0.1916
Echinococcus multilocularis proteasome subunit beta type 7 0.0016 0.0045 0.0045
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0016 0.0045 0.0036
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0016 0.0045 0.0036
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.4016 0.4016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1036 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0861 0.8293 0.8292
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0062 0.0496 0.0487
Echinococcus granulosus EF HAND 1 calcium binding site 0.0012 0.0009 0.0009
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0016 0.0045 0.0045
Onchocerca volvulus 0.1036 1 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.029 0.0281
Schistosoma mansoni lamin 0.0028 0.0164 0.0155
Schistosoma mansoni chromobox protein 0.0068 0.0551 0.0543
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0016 0.0045 0.0036
Loa Loa (eye worm) transcriptional regulator 0.0065 0.0525 0.0523
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0544 0.5195 0.519
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0053 0.041 0.0408
Echinococcus multilocularis cathepsin L 0.0544 0.5195 0.5195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1036 1 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0279 0.2617 0.261
Leishmania major sir2-family protein-like protein 0.0065 0.0525 0.0517
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0016 0.0045 0.0036
Echinococcus multilocularis cathepsin b 0.0861 0.8293 0.8293
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0252 0.2355 0.2348
Trypanosoma brucei cysteine peptidase, putative 0.003 0.0185 0.0176
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0017 0.0014
Leishmania major cathepsin L-like protease 0.1036 1 1
Trypanosoma brucei Calpain-like protein 1.1 0.003 0.0185 0.0176
Plasmodium vivax proteasome subunit beta type-7, putative 0.0016 0.0045 0.0036
Echinococcus granulosus lamin 0.0028 0.0164 0.0164
Onchocerca volvulus 0.1036 1 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0016 0.0045 0.5
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.008 0.0669 0.0661
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1036 1 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0208 0.1918 0.1911
Trypanosoma cruzi calpain cysteine peptidase, putative 0.003 0.0185 0.0176
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0016 0.0045 0.0036
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0252 0.2355 0.2348
Toxoplasma gondii proteasome subunit alpha1, putative 0.0016 0.0045 0.0036
Schistosoma mansoni hypothetical protein 0.0032 0.02 0.0191
Echinococcus granulosus inhibitor of apoptosis protein 0.0053 0.041 0.041
Giardia lamblia Cathepsin L-like protease 0.0208 0.1918 0.4919
Brugia malayi calpain 5 0.003 0.0185 0.0183
Onchocerca volvulus 0.0041 0.0289 0.0289
Brugia malayi intermediate filament protein 0.0028 0.0164 0.0162
Schistosoma mansoni tar DNA-binding protein 0.0064 0.052 0.0512
Plasmodium vivax unspecified product 0.0544 0.5195 0.519
Trypanosoma brucei hypothetical protein 0.003 0.0185 0.0176
Schistosoma mansoni tar DNA-binding protein 0.0064 0.052 0.0512
Entamoeba histolytica cysteine proteinase, putative 0.1036 1 1
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0016 0.0045 0.0036
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0016 0.0045 0.0036
Trypanosoma cruzi kinesin, putative 0.007 0.0574 0.0565
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0208 0.1918 0.1911
Giardia lamblia Cysteine protease 0.0208 0.1918 0.4919
Trypanosoma brucei Calpain-like protein 1.2 0.003 0.0185 0.0176
Mycobacterium ulcerans proteasome PrcB 0.008 0.0669 0.6899
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0208 0.1918 0.1911
Trypanosoma cruzi cysteine peptidase, putative 0.1036 1 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.01 0.0867 0.0859
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.003 0.0185 0.0176
Giardia lamblia Cathepsin B precursor 0.041 0.389 1
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0038 0.0266 0.0257
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0016 0.0045 0.0036
Entamoeba histolytica cysteine protease, putative 0.0544 0.5195 0.519
Loa Loa (eye worm) TAR-binding protein 0.0064 0.052 0.0518
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0208 0.1918 0.1911
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0065 0.0525 0.0525
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0016 0.0045 0.0036
Brugia malayi cathepsin Z-like cysteine proteinase 0.0208 0.1918 0.1916
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0551 0.0543
Echinococcus granulosus Proteasome subunit alpha beta 0.0016 0.0045 0.0045
Onchocerca volvulus 0.07 0.6724 0.6724
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0016 0.0045 0.0036
Loa Loa (eye worm) calpain 0.01 0.0867 0.0865
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0038 0.0266 0.0266
Echinococcus multilocularis hypothetical protein 0.01 0.0867 0.0867
Trypanosoma brucei calpain-like protein, putative 0.01 0.0867 0.0859
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0065 0.0525 0.0525
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0016 0.0045 0.0036
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0062 0.0496 0.0487
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.1918 0.1911
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0016 0.0045 0.0036
Loa Loa (eye worm) calmodulin-like protein 0.0012 0.0009 0.0007
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0062 0.0496 0.0487
Brugia malayi proteasome subunit alpha type 3 0.0016 0.0045 0.0042
Echinococcus granulosus survival motor neuron protein 1 0.023 0.2132 0.2132
Loa Loa (eye worm) hypothetical protein 0.0336 0.3168 0.3167
Brugia malayi cathepsin L-like precursor 0.07 0.6724 0.6723
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.003 0.0185 0.0176
Brugia malayi Proteasome A-type and B-type family protein 0.0016 0.0045 0.0042
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0065 0.0525 0.0517
Loa Loa (eye worm) hypothetical protein 0.07 0.6724 0.6723
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0016 0.0045 0.0036
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0208 0.1918 0.1916
Mycobacterium tuberculosis Hypothetical protein 0.0108 0.095 1
Plasmodium vivax proteasome subunit beta type-2, putative 0.0038 0.0266 0.0257
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0016 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.0208 0.1918 0.1916
Brugia malayi cathepsin F-like cysteine proteinase 0.0208 0.1918 0.1916
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.1675 0.1675
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0277 0.2593 0.2587
Echinococcus granulosus neuronal calcium sensor 0.0012 0.0009 0.0009
Brugia malayi cathepsin Z-like cysteine proteinase 0.0208 0.1918 0.1916
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0016 0.0045 0.0092
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0164 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1036 1 1
Entamoeba histolytica cysteine protease, putative 0.0544 0.5195 0.519
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0016 0.0045 0.0042
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0038 0.0266 0.0257
Plasmodium falciparum serine repeat antigen 8 0.0208 0.1918 0.1911
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0066 0.0057
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0016 0.0045 0.0036
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0016 0.0045 0.0045
Mycobacterium leprae Conserved hypothetical protein 0.0108 0.095 1
Brugia malayi Pre-SET motif family protein 0.003 0.0181 0.0179
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0016 0.0045 0.0036
Loa Loa (eye worm) hypothetical protein 0.0195 0.1795 0.1793
Giardia lamblia 20S proteasome alpha subunit 5 0.0016 0.0045 0.0092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0208 0.1918 0.1911
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0182 0.0179
Brugia malayi proteasome subunit beta type 1 0.0062 0.0496 0.0494
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0065 0.0525 0.0517
Brugia malayi proteasome subunit alpha type 6 0.0016 0.0045 0.0042
Entamoeba histolytica cysteine protease, putative 0.0544 0.5195 0.519
Schistosoma mansoni calpain C (C02 family) 0.01 0.0867 0.0859
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.01 0.0867 0.0859
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.01 0.0867 0.0859
Schistosoma mansoni cathepsin S (C01 family) 0.0208 0.1918 0.1911
Onchocerca volvulus 0.1036 1 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0208 0.1918 0.1911
Entamoeba histolytica protein kinase, putative 0.007 0.0574 0.0565
Echinococcus granulosus calpain A 0.01 0.0867 0.0867
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0336 0.3168 0.3167
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0016 0.0045 0.0036
Schistosoma mansoni lamin 0.0028 0.0164 0.0155
Brugia malayi proteasome subunit beta type 3 0.0016 0.0045 0.0042
Onchocerca volvulus 0.0012 0.0009 0.0009
Brugia malayi TAR-binding protein 0.0064 0.052 0.0518
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0016 0.0045 0.0042
Trypanosoma brucei calpain-like protein, putative 0.01 0.0867 0.0859
Giardia lamblia Cathepsin B precursor 0.0208 0.1918 0.4919
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0038 0.0266 0.0257
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.003 0.0185 0.0176
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0208 0.1918 0.1911
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0012 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1036 1 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0208 0.1918 0.1911
Brugia malayi Cathepsin L-like precursor 0.0336 0.3168 0.3167
Schistosoma mansoni hypothetical protein 0.0032 0.02 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0262 0.0253
Schistosoma mansoni chromatin regulatory protein sir2 0.0252 0.2355 0.2348
Entamoeba histolytica cysteine protease, putative 0.0544 0.5195 0.519
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0467 0.4665
Loa Loa (eye worm) hypothetical protein 0.0068 0.0557 0.0555
Giardia lamblia 20S proteasome alpha subunit 2 0.0016 0.0045 0.0092
Schistosoma mansoni tar DNA-binding protein 0.0064 0.052 0.0512
Toxoplasma gondii proteasome subunit alpha type, putative 0.0016 0.0045 0.0036
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0016 0.0045 0.0036
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Schistosoma mansoni cathepsin s 0.0336 0.3168 0.3162
Echinococcus multilocularis calpain 0.01 0.0867 0.0867
Brugia malayi Proteasome subunit alpha type 7-1 0.0016 0.0045 0.0042
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.003 0.0185 0.0176
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.008 0.0669 0.0667
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0016 0.0045 0.0036
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0016 0.0045 0.0036
Toxoplasma gondii cathepsin CPC1 0.0208 0.1918 0.1911
Plasmodium falciparum calpain 0.003 0.0185 0.0176
Schistosoma mansoni hypothetical protein 0.0164 0.1496 0.1488
Loa Loa (eye worm) hypothetical protein 0.003 0.0182 0.018
Echinococcus multilocularis proteasome subunit alpha type 2 0.0016 0.0045 0.0045
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0164 0.0162
Brugia malayi hypothetical protein 0.023 0.2132 0.213
Echinococcus granulosus tar DNA binding protein 0.0064 0.052 0.052
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.029 0.029
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0016 0.0045 0.0045
Echinococcus multilocularis calmodulin 0.0012 0.0009 0.0009
Echinococcus multilocularis proteasome subunit alpha type 6 0.0016 0.0045 0.0045
Brugia malayi proteasome subunit alpha type 4 0.0016 0.0045 0.0042
Brugia malayi chromobox protein homolog 3 0.0038 0.0262 0.0259
Onchocerca volvulus 0.003 0.0182 0.0182
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0467 0.0458
Brugia malayi Cathepsin L-like precursor 0.1036 1 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.02 0.0197
Giardia lamblia Hypothetical protein 0.0208 0.1918 0.4919
Leishmania major proteasome alpha 3 subunit, putative 0.0016 0.0045 0.0036
Toxoplasma gondii peptidase, T1 family protein 0.0016 0.0045 0.0036
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0016 0.0045 0.0036
Echinococcus multilocularis chromobox protein 1 0.0068 0.0551 0.0551
Leishmania major silent information regulator 2, putative 0.0252 0.2355 0.2348
Giardia lamblia Hypothetical protein 0.0252 0.2355 0.6045
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0062 0.0496 0.0496
Entamoeba histolytica cysteine protease, putative 0.0544 0.5195 0.519
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.1675 0.1675
Echinococcus granulosus cathepsin L 0.0544 0.5195 0.5195
Leishmania major proteasome alpha 7 subunit, putative 0.0016 0.0045 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0208 0.1918 0.1911
Giardia lamblia Proteasome subunit beta type 1 0.0062 0.0496 0.1254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1036 1 1
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0016 0.0045 0.0036
Echinococcus multilocularis calumenin 0.0012 0.0009 0.0009
Schistosoma mansoni calpain-7 (C02 family) 0.01 0.0867 0.0859
Loa Loa (eye worm) calpain D 0.003 0.0185 0.0183
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0208 0.1918 0.1911
Brugia malayi EF hand family protein 0.0012 0.0009 0.0007
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0016 0.0045 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1036 1 1
Giardia lamblia Cathepsin L precursor 0.0208 0.1918 0.4919
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0038 0.0266 0.0257
Schistosoma mansoni chromatin regulatory protein sir2 0.0065 0.0525 0.0517
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0016 0.0045 0.0036
Trypanosoma cruzi cysteine peptidase, putative 0.1036 1 1
Plasmodium falciparum proteasome subunit beta type-4 0.0016 0.0045 0.0036
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.02 0.02
Plasmodium falciparum serine repeat antigen 9 0.0208 0.1918 0.1911
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0551 0.0543
Onchocerca volvulus 0.0028 0.0164 0.0164
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.07 0.6724 0.6721
Echinococcus multilocularis cysteine protease 0.1036 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0208 0.1918 0.1911
Onchocerca volvulus 0.0053 0.041 0.041
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0208 0.1918 0.1911
Echinococcus multilocularis cathepsin b 0.0861 0.8293 0.8293
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1022 0.102
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0016 0.0045 0.0036
Brugia malayi transcriptional regulator, Sir2 family protein 0.0065 0.0525 0.0523
Echinococcus multilocularis cysteine protease 0.1036 1 1
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0016 0.0045 0.0036
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.01 0.0867 0.0859
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0016 0.0045 0.0036
Onchocerca volvulus 0.0208 0.1918 0.1918
Onchocerca volvulus Deterin homolog 0.0053 0.041 0.041
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1036 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.02 0.02
Plasmodium falciparum serine repeat antigen 4 0.0208 0.1918 0.1911
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.052 0.0518
Echinococcus granulosus cathepsin L 0.0208 0.1918 0.1918
Onchocerca volvulus Cathepsin L homolog 0.1036 1 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0016 0.0045 0.0036
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0016 0.0045 0.0042
Onchocerca volvulus 0.1036 1 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0016 0.0045 0.0036
Plasmodium falciparum serine repeat antigen 2 0.0208 0.1918 0.1911
Trypanosoma cruzi cysteine protease, putative 0.0544 0.5195 0.519
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.003 0.0185 0.0176
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0053 0.041 0.041
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0289 0.028
Schistosoma mansoni chromatin regulatory protein sir2 0.0252 0.2355 0.2348
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0066 0.0057
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0208 0.1918 0.1911
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0038 0.0266 0.0257
Schistosoma mansoni cathepsin B (C01 family) 0.0208 0.1918 0.1911
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0467 0.0458
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0016 0.0045 0.0036
Giardia lamblia Cathepsin B precursor 0.0208 0.1918 0.4919
Echinococcus granulosus subfamily T1A non peptidase ue 0.0016 0.0045 0.0045
Giardia lamblia Encystation-specific protease 0.0208 0.1918 0.4919
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0208 0.1918 0.4919
Leishmania major cathepsin L-like protease 0.1036 1 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.003 0.0185 0.0176
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0016 0.0045 0.0036
Brugia malayi CXXC zinc finger family protein 0.003 0.0182 0.0179
Trypanosoma cruzi major cysteine proteinase, putative 0.0208 0.1918 0.1911
Brugia malayi cathepsin L-like cysteine proteinase 0.0208 0.1918 0.1916
Toxoplasma gondii heat shock protein hslv, putative 0.0016 0.0045 0.0036
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.003 0.0185 0.0176
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0016 0.0045 0.0036
Leishmania major cathepsin L-like protease 0.1036 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 28 uM Inhibition of the tyrosine kinase activity of the human epidermal growth factor receptor (EGFR) ChEMBL. 7510340
IC50 (binding) = 28 uM Inhibition of the tyrosine kinase activity of the human epidermal growth factor receptor (EGFR) ChEMBL. 7510340

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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