TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 588.636 | Formula: C25H32N8O7S
H donors: 6 H acceptors: 9 LogP: 0.48 Rotable bonds: 11
Rule of 5 violations (Lipinski): 3
SMILES: CCNC(=O)[C@@H]1O[C@@H]([C@H]([C@@H]1O)O)n1cnc2c1ncnc2NC(=O)Nc1ccc(cc1)S(=O)(=O)NC1CCCCC1
InChi: 1S/C25H32N8O7S/c1-2-26-23(36)20-18(34)19(35)24(40-20)33-13-29-17-21(27-12-28-22(17)33)31-25(37)30-14-8-10-16(11-9-14)41(38,39)32-15-6-4-3-5-7-15/h8-13,15,18-20,24,32,34-35H,2-7H2,1H3,(H,26,36)(H2,27,28,30,31,37)/t18-,19+,20?,24-/m1/s1
InChiKey: DGSYKWLOYSOBQK-NNYGOGDTSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	calmodulin, putative	0.0054	0.004	0.0058
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.027	0.2767	0.2767
Schistosoma mansoni	rab	0.0052	0.0022	0.0022
Entamoeba histolytica	cysteine protease, putative	0.0103	0.0665	0.3735
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0178	0.1602	0.5113
Echinococcus granulosus	caspase 2	0.0059	0.0106	0.0084
Loa Loa (eye worm)	calpain family protein 1	0.0527	0.6008	0.6008
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0103	0.0665	0.407
Toxoplasma gondii	cathepsin CPC1	0.0053	0.0026	0.0013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.1602	0.5113
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0026	0.0026
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0297	0.3111	0.3111
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0768	0.905	0.9048
Brugia malayi	Cathepsin L-like precursor	0.0178	0.1602	0.1602
Entamoeba histolytica	cysteine proteinase, putative	0.0178	0.1602	0.9177
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0022	0.0022
Brugia malayi	Cathepsin L-like precursor	0.0127	0.0963	0.0963
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.027	0.2767	0.8886
Entamoeba histolytica	cysteine protease, putative	0.0103	0.0665	0.3735
Trypanosoma cruzi	centrin, putative	0.0052	0.0022	0.0022
Plasmodium vivax	unspecified product	0.0103	0.0665	0.2403
Plasmodium vivax	serine-repeat antigen (SERA)	0.0053	0.0026	0.0095
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.1602	0.5113
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0768	0.905	0.905
Entamoeba histolytica	cysteine protease, putative	0.0103	0.0665	0.3735
Echinococcus granulosus	calcium uptake protein 1	0.0054	0.004	0.0018
Entamoeba histolytica	cysteine proteinase, putative	0.0103	0.0665	0.3735
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0178	0.1602	1
Entamoeba histolytica	hypothetical protein	0.0053	0.0026	0.0024
Echinococcus multilocularis	cathepsin L	0.0103	0.0665	0.0644
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.027	0.2767	0.2767
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.1602	0.5113
Echinococcus multilocularis	snurportin 1	0.0316	0.3344	0.3329
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0053	0.0026	0.0095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.1602	0.5113
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0053	0.0026	0.0095
Giardia lamblia	Hypothetical protein	0.0054	0.004	0.0045
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0053	0.0026	0.0026
Brugia malayi	Papain family cysteine protease containing protein	0.0178	0.1602	0.1602
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0053	0.0026	0.0026
Onchocerca volvulus	Cell death protein 3 homolog	0.0059	0.0106	0.0169
Echinococcus multilocularis	EF hand domain containing family member A2	0.0054	0.004	0.0018
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0026	0.0024
Schistosoma mansoni	calpain-7 (C02 family)	0.027	0.2767	0.2767
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0297	0.3111	1
Trichomonas vaginalis	calmodulin, putative	0.0054	0.004	0.0058
Leishmania major	cathepsin L-like protease	0.0178	0.1602	0.5113
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.0385
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0844	1	1
Loa Loa (eye worm)	hypothetical protein	0.0446	0.4984	0.4984
Trypanosoma cruzi	major cysteine proteinase, putative	0.0053	0.0026	0.0026
Entamoeba histolytica	grainin, putative	0.0054	0.004	0.0104
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.1602	0.5113
Trichomonas vaginalis	hypothetical protein	0.0081	0.0385	0.1175
Schistosoma mansoni	centrin-related	0.0052	0.0022	0.0022
Brugia malayi	Calmodulin-like protein	0.0052	0.0022	0.0022
Onchocerca volvulus		0.0127	0.0963	0.1896
Trypanosoma cruzi	kinesin, putative	0.0189	0.1743	0.1743
Echinococcus granulosus	cathepsin L cysteine protease	0.0103	0.0665	0.0644
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.027	0.2767	0.2767
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0178	0.1602	0.5113
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0022	0.0022
Echinococcus granulosus	calbindin 32	0.0054	0.004	0.0018
Leishmania major	cysteine peptidase A (CPA)	0.0178	0.1602	0.5113
Entamoeba histolytica	cysteine proteinase, putative	0.0103	0.0665	0.3735
Schistosoma mansoni	ef hand domain family member A2	0.0052	0.0022	0.0022
Loa Loa (eye worm)	ctsf protein	0.0178	0.1602	0.1602
Trypanosoma cruzi	caltractin, putative	0.0052	0.0022	0.0022
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0026	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.1602	0.5113
Echinococcus multilocularis	calpain	0.027	0.2767	0.2751
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0127	0.0963	0.0963
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0026	0.0013
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0178	0.1602	0.1602
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0236	0.2337	0.5
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0081	0.0385	0.0385
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.0385
Echinococcus multilocularis	cathepsin L cysteine protease	0.0178	0.1602	0.1583
Onchocerca volvulus		0.0054	0.004	0.0036
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0053	0.0026	0.0026
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.0385
Echinococcus multilocularis	calbindin 32	0.0054	0.004	0.0018
Trypanosoma cruzi	calmodulin, putative	0.0052	0.0022	0.0022
Schistosoma mansoni	calcium binding atopy-related autoantigen	0.0054	0.004	0.004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0178	0.1602	0.5113
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.027	0.2767	0.2767
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.1175
Schistosoma mansoni	calmodulin related calcium binding protein	0.0052	0.0022	0.0022
Echinococcus granulosus	EF hand domain containing family member A2	0.0054	0.004	0.0018
Brugia malayi	calpain family protein 1	0.0716	0.839	0.839
Trypanosoma cruzi	cysteine peptidase, putative	0.0103	0.0665	0.0665
Brugia malayi	calpain family protein 1	0.0716	0.839	0.839
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0178	0.1602	0.1602
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0178	0.1602	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.1602	0.5113
Entamoeba histolytica	cysteine protease, putative	0.0103	0.0665	0.3735
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0026	0.0026
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0053	0.0026	0.0026
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0053	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0026	0.0026
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0053	0.0026	0.0026
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0026	0.0013
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0053	0.0026	0.0026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0026	0.0013
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0178	0.1602	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.1602	0.5113
Giardia lamblia	Cathepsin B precursor	0.0297	0.3111	1
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0081	0.0385	0.0385
Echinococcus granulosus	calpain 7 C02 family	0.027	0.2767	0.2751
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0081	0.0385	0.1175
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0127	0.0963	0.0963
Loa Loa (eye worm)	cathepsin B	0.0297	0.3111	0.3111
Trypanosoma cruzi	I/6 autoantigen, putative	0.0052	0.0022	0.0022
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0178	0.1602	0.1583
Echinococcus multilocularis	cathepsin L	0.0053	0.0026	0.0004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0026	0.0013
Plasmodium vivax	serine-repeat antigen (SERA)	0.0053	0.0026	0.0095
Schistosoma mansoni	calmodulin	0.0052	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0963	0.0963
Loa Loa (eye worm)	hypothetical protein	0.0527	0.6008	0.6008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0026	0.0013
Entamoeba histolytica	cysteine protease, putative	0.0178	0.1602	0.9177
Entamoeba histolytica	hypothetical protein, conserved	0.0054	0.004	0.0104
Plasmodium vivax	calpain, putative	0.027	0.2767	1
Echinococcus multilocularis	calpain family protein 1, d	0.0527	0.6008	0.5999
Brugia malayi	cathepsin L-like precursor	0.0127	0.0963	0.0963
Brugia malayi	calpain D	0.0081	0.0385	0.0385
Trypanosoma brucei	Calpain-like protein 1.2	0.0081	0.0385	0.1175
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.1602	0.5113
Plasmodium vivax	vivapain-3	0.0103	0.0665	0.2403
Trypanosoma brucei	antigen, putative	0.027	0.2767	0.8886
Schistosoma mansoni	calpain (C02 family)	0.027	0.2767	0.2767
Schistosoma mansoni	cathepsin B (C01 family)	0.0053	0.0026	0.0026
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0053	0.0026	0.0026
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0844	1	1
Entamoeba histolytica	calpain family cysteine protease, putative	0.0081	0.0385	0.2109
Leishmania major	calpain protease-like protein	0.0081	0.0385	0.1175
Entamoeba histolytica	cysteine proteinase, putative	0.0103	0.0665	0.3735
Entamoeba histolytica	cysteine protease, putative	0.0103	0.0665	0.3735
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.0963	0.3046
Trypanosoma cruzi	kinesin, putative	0.0189	0.1743	0.1743
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0052	0.0022	0.008
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0178	0.1602	0.5113
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0053	0.0026	0.0013
Entamoeba histolytica	cysteine protease, putative	0.0103	0.0665	0.3735
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0053	0.0026	0.0026
Schistosoma mansoni	cathepsin S (C01 family)	0.0053	0.0026	0.0026
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0026	0.0024
Schistosoma mansoni	hypothetical protein	0.0081	0.0385	0.0385
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0081	0.0385	0.1175
Leishmania major	cathepsin L-like protease	0.0178	0.1602	0.5113
Schistosoma mansoni	calpain-2 (C02 family)	0.0081	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0026	0.0026
Trichomonas vaginalis	calpain, putative	0.0081	0.0385	0.1175
Trypanosoma brucei	calpain, putative	0.0081	0.0385	0.1175
Brugia malayi	EF hand family protein	0.0054	0.004	0.004
Toxoplasma gondii	calpain family cysteine protease domain-containing protein	0.0081	0.0385	0.1175
Echinococcus granulosus	cathepsin b	0.0844	1	1
Trypanosoma cruzi	I/6 autoantigen, putative	0.0052	0.0022	0.0022
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0053	0.0026	0.0013
Trypanosoma cruzi	mitochondrial calcium uptake 1, putative	0.0052	0.0022	0.0022
Onchocerca volvulus	Cathepsin F homolog	0.0178	0.1602	0.3183
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0053	0.0026	0.0013
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0053	0.0026	0.0013
Plasmodium falciparum	serine repeat antigen 2	0.0053	0.0026	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.1602	0.5113
Echinococcus granulosus	cathepsin L	0.0053	0.0026	0.0004
Brugia malayi	calpain 5	0.0189	0.1743	0.1743
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0385	0.1175
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0178	0.1602	0.5113
Entamoeba histolytica	cysteine protease, putative	0.0103	0.0665	0.3735
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.1175
Leishmania major	calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.1175
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0081	0.0385	0.0385
Echinococcus granulosus	calpain 5	0.027	0.2767	0.2751
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.0385
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.1602	0.5113
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0026	0.0026
Trypanosoma brucei	kinesin, putative	0.0189	0.1743	0.5572
Onchocerca volvulus		0.0178	0.1602	0.3183
Echinococcus multilocularis	calpain 7 (C02 family)	0.027	0.2767	0.2751
Trypanosoma brucei	Calpain-like protein 2	0.0081	0.0385	0.1175
Schistosoma mansoni	cathepsin F (C01 family)	0.0178	0.1602	0.1602
Schistosoma mansoni	neuronal calcium sensor	0.0052	0.0022	0.0022
Brugia malayi	EF hand family protein	0.0052	0.0022	0.0022
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.1602	0.5113
Echinococcus multilocularis	hypothetical protein	0.027	0.2767	0.2751
Trypanosoma brucei	Calpain-like protein 1.1	0.0081	0.0385	0.1175
Plasmodium vivax	vivapain-2	0.0178	0.1602	0.5788
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0385	0.0385
Echinococcus multilocularis	cathepsin L cysteine protease	0.0178	0.1602	0.1583
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0316	0.3344	0.3344
Echinococcus granulosus	cathepsin l1	0.0178	0.1602	0.1583
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0053	0.0026	0.0095
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0178	0.1602	0.1583
Schistosoma mansoni	calpain C (C02 family)	0.027	0.2767	0.2767
Schistosoma mansoni	reticulocalbin	0.0052	0.0022	0.0022
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.1602	0.5113
Toxoplasma gondii	cathepsin CPC2	0.0053	0.0026	0.0013
Brugia malayi	calpain 5	0.0081	0.0385	0.0385
Onchocerca volvulus		0.0178	0.1602	0.3183
Toxoplasma gondii	cathepsin CPL	0.0178	0.1602	0.5113
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.1175
Schistosoma mansoni	neuronal calcium sensor	0.0052	0.0022	0.0022
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0081	0.0385	0.1175
Echinococcus granulosus	calpain	0.027	0.2767	0.2751
Toxoplasma gondii	calmodulin CAM1	0.0054	0.004	0.0058
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.1175
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.1602	0.5113
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.0963	0.3046
Schistosoma mansoni	cathepsin F (C01 family)	0.0178	0.1602	0.1602
Echinococcus multilocularis	calpain 5	0.027	0.2767	0.2751
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0103	0.0665	0.0665
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0053	0.0026	0.0095
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0053	0.0026	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.1602	0.5113
Loa Loa (eye worm)	hypothetical protein	0.0716	0.839	0.839
Trypanosoma brucei	calpain-like protein, putative	0.027	0.2767	0.8886
Brugia malayi	Cathepsin L-like precursor	0.0127	0.0963	0.0963
Trypanosoma cruzi	cysteine peptidase, putative	0.0178	0.1602	0.1602
Entamoeba histolytica	cysteine proteinase, putative	0.0178	0.1602	0.9177
Loa Loa (eye worm)	fibroinase	0.0178	0.1602	0.1602
Leishmania major	hypothetical protein, conserved	0.0054	0.004	0.0058
Trypanosoma brucei	calpain-like protein, putative	0.027	0.2767	0.8886
Onchocerca volvulus	Cathepsin L homolog	0.0178	0.1602	0.3183
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.027	0.2767	0.8886
Schistosoma mansoni	Sarcoplasmic calcium-binding protein (SCP).	0.0052	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0106	0.0106
Brugia malayi	cathepsin L-like cysteine proteinase	0.0053	0.0026	0.0026
Entamoeba histolytica	cysteine proteinase, putative	0.0103	0.0665	0.3735
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.1175
Echinococcus granulosus	cathepsin l1	0.0127	0.0963	0.0943
Echinococcus multilocularis	calcium uptake protein 1	0.0054	0.004	0.0018
Echinococcus granulosus	cathepsin L	0.0103	0.0665	0.0644
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0963	0.0963
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0189	0.1743	1
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.027	0.2767	0.8886
Onchocerca volvulus		0.0178	0.1602	0.3183
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0178	0.1602	0.1602
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0054	0.004	0.004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.1602	0.5113
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.0385
Plasmodium falciparum	serine repeat antigen 1	0.0053	0.0026	0.0026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.1602	0.5113
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0026	0.0013
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0768	0.905	0.905
Echinococcus multilocularis	calumenin	0.0054	0.004	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0297	0.3111	1
Loa Loa (eye worm)	calpain D	0.0081	0.0385	0.0385
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0052	0.0022	0.0022
Trypanosoma cruzi	cysteine protease, putative	0.0103	0.0665	0.0665
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.0665	0.2081
Echinococcus granulosus	cysteine protease	0.0103	0.0665	0.0644
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0026	0.0013
Plasmodium falciparum	serine repeat antigen 5	0.0053	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0026	0.0026
Onchocerca volvulus	Cathepsin L homolog	0.0053	0.0026	0.0008
Entamoeba histolytica	cysteine protease, putative	0.0103	0.0665	0.3735
Onchocerca volvulus		0.0178	0.1602	0.3183
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0103	0.0665	0.0665
Leishmania major	cathepsin L-like protease	0.0178	0.1602	0.5113
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0081	0.0385	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0026	0.0026
Leishmania major	calpain family cysteine protease-like protein	0.0081	0.0385	0.1175
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0053	0.0026	0.0095
Trypanosoma cruzi	calmodulin, putative	0.0052	0.0022	0.0022
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0081	0.0385	0.0385
Schistosoma mansoni	hypothetical protein	0.0052	0.0022	0.0022
Trypanosoma cruzi	cysteine proteinase, putative	0.0103	0.0665	0.0665
Schistosoma mansoni	cathepsin F (C01 family)	0.0127	0.0963	0.0963
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0026	0.0026
Loa Loa (eye worm)	calmodulin-like protein	0.0052	0.0022	0.0022
Leishmania major	hypothetical protein, unknown function	0.0081	0.0385	0.1175
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.1175
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.1175
Entamoeba histolytica	protein kinase, putative	0.0189	0.1743	1
Onchocerca volvulus		0.0178	0.1602	0.3183
Brugia malayi	RNA, U transporter 1	0.0084	0.0422	0.0422
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0178	0.1602	0.1583
Loa Loa (eye worm)	hypothetical protein	0.0844	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0103	0.0665	0.0665
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.027	0.2767	0.2767
Trypanosoma brucei	cytoskeleton-associated protein CAP5.5, putative	0.0081	0.0385	0.1175
Schistosoma mansoni	reticulocalbin	0.0054	0.004	0.004
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0053	0.0026	0.0095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0026	0.0013
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0053	0.0026	0.0013
Trypanosoma cruzi	centrin, putative	0.0052	0.0022	0.0022
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0081	0.0385	0.0385
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0297	0.3111	1
Plasmodium falciparum	serine repeat antigen 7	0.0053	0.0026	0.0026
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.027	0.2767	0.2767
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.027	0.2767	0.8886
Echinococcus granulosus	calpain A	0.077	0.9068	0.9066
Plasmodium falciparum	serine repeat antigen 6	0.0053	0.0026	0.0026
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0081	0.0385	0.1175
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.0385
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0081	0.0385	0.0385
Trypanosoma brucei	calpain-like protein, putative	0.027	0.2767	0.8886
Onchocerca volvulus	Cathepsin L homolog	0.0178	0.1602	0.3183
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0081	0.0385	0.0385
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.0385
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0026	0.0024
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0026	0.0024
Echinococcus granulosus	snurportin 1	0.0316	0.3344	0.3329
Toxoplasma gondii	calcium-dependent protein kinase	0.0054	0.004	0.0058
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.1175
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.1175
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0053	0.0026	0.0013
Trypanosoma brucei	cysteine peptidase, putative	0.0081	0.0385	0.1175
Schistosoma mansoni	neuronal calcium sensor	0.0052	0.0022	0.0022
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0103	0.0665	0.0665
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0844	1	1
Schistosoma mansoni	cathepsin C	0.0053	0.0026	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0103	0.0665	0.2081
Plasmodium falciparum	serine repeat antigen 4	0.0053	0.0026	0.0026
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0103	0.0665	0.0665
Echinococcus granulosus	cathepsin b	0.0844	1	1
Trypanosoma cruzi	conserved protein	0.0081	0.0385	0.0385
Onchocerca volvulus		0.0446	0.4984	1
Trypanosoma brucei	calpain-like protein, putative	0.027	0.2767	0.8886
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.1175
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0178	0.1602	0.5113
Loa Loa (eye worm)	hypothetical protein	0.0635	0.7366	0.7366
Trypanosoma brucei	hypothetical protein	0.0081	0.0385	0.1175
Entamoeba histolytica	cysteine protease, putative	0.0103	0.0665	0.3735
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0081	0.0385	0.1175
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.1175
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0178	0.1602	0.5113
Plasmodium falciparum	serine repeat antigen 9	0.0053	0.0026	0.0026
Giardia lamblia	Cathepsin B precursor	0.0297	0.3111	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0716	0.839	0.839
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0053	0.0026	0.0026
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.1175
Schistosoma mansoni	hypothetical protein	0.0052	0.0022	0.0022
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0026	0.0013
Trypanosoma brucei	glucosamine 6-phosphate n-acetyltransferase	0.0081	0.0385	0.1175
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.027	0.2767	0.2767
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0053	0.0026	0.0026
Schistosoma mansoni	caspase-7 (C14 family)	0.0059	0.0106	0.0106
Brugia malayi	Cathepsin L-like precursor	0.0178	0.1602	0.1602
Trypanosoma cruzi	centrin-3	0.0052	0.0022	0.0022
Loa Loa (eye worm)	EF hand family protein	0.0052	0.0022	0.0022
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.1602	0.5113
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0844	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0053	0.0026	0.0026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.1602	0.5113
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.027	0.2767	0.8886
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.0026	0.0026
Leishmania major	cathepsin L-like protease	0.0178	0.1602	0.5113
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0081	0.0385	0.0385
Onchocerca volvulus		0.0178	0.1602	0.3183
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.027	0.2767	0.2767
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0297	0.3111	0.3111
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0053	0.0026	0.0095
Loa Loa (eye worm)	calpain	0.027	0.2767	0.2767
Entamoeba histolytica	cysteine proteinase 1, putative	0.0103	0.0665	0.3735
Schistosoma mansoni	neuronal calcium sensor	0.0052	0.0022	0.0022
Brugia malayi	Cathepsin L-like precursor	0.0178	0.1602	0.1602
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.0385
Brugia malayi	Papain family cysteine protease containing protein	0.0103	0.0665	0.0665
Echinococcus multilocularis	calpain A	0.077	0.9068	0.9066
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.1175
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0052	0.0022	0.0022
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.1602	0.5113
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.027	0.2767	0.2767
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.0026	0.0026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0178	0.1602	0.5113
Trypanosoma brucei	Calpain-like protein CALP1.3	0.0081	0.0385	0.1175
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0844	1	1
Brugia malayi	cathepsin L precursor	0.0053	0.0026	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0103	0.0665	0.2081
Brugia malayi	calcium-binding protein	0.0052	0.0022	0.0022
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0768	0.905	0.9048
Entamoeba histolytica	cysteine protease, putative	0.0103	0.0665	0.3735
Loa Loa (eye worm)	cysteine protease	0.0178	0.1602	0.1602
Echinococcus multilocularis	cathepsin b	0.0844	1	1
Leishmania major	cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.1175
Schistosoma mansoni	calpain-7 (C02 family)	0.027	0.2767	0.2767
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.1602	0.5113
Entamoeba histolytica	cysteine protease, putative	0.0103	0.0665	0.3735
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.1602	0.5113
Trypanosoma cruzi	cysteine peptidase, putative	0.0178	0.1602	0.1602
Schistosoma mansoni	Mername-AA248 (C02 family)	0.027	0.2767	0.2767
Entamoeba histolytica	cysteine protease, putative	0.0103	0.0665	0.3735
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0963	0.0963
Brugia malayi	Cathepsin L-like precursor	0.0178	0.1602	0.1602
Loa Loa (eye worm)	calpain family protein 1	0.0716	0.839	0.839
Loa Loa (eye worm)	calpain 5	0.0189	0.1743	0.1743
Onchocerca volvulus		0.0178	0.1602	0.3183
Schistosoma mansoni	centrin	0.0052	0.0022	0.0022
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0081	0.0385	0.1175
Toxoplasma gondii	hypothetical protein	0.0081	0.0385	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0026	0.0026
Trypanosoma cruzi	major cysteine proteinase, putative	0.0053	0.0026	0.0026
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0053	0.0026	0.0013
Leishmania major	cathepsin L-like protease	0.0178	0.1602	0.5113
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0178	0.1602	0.5113
Toxoplasma gondii	cathepsin B	0.0297	0.3111	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.1602	0.5113
Entamoeba histolytica	cysteine protease, putative	0.0103	0.0665	0.3735
Loa Loa (eye worm)	programmed cell death protein 6	0.0054	0.004	0.004
Echinococcus granulosus	calpain A	0.027	0.2767	0.2751
Trichomonas vaginalis	calpain, putative	0.0081	0.0385	0.1175
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0052	0.0022	0.0022
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0053	0.0026	0.0013
Trypanosoma brucei	calpain, putative	0.0081	0.0385	0.1175
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0053	0.0026	0.0024
Trypanosoma cruzi	cysteine peptidase, putative	0.0178	0.1602	0.1602
Leishmania major	kinesin, putative	0.0189	0.1743	0.5572
Schistosoma mansoni	calmodulin	0.0052	0.0022	0.0022
Brugia malayi	Cell death protein 3 precursor	0.0059	0.0106	0.0106
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0026	0.0024
Giardia lamblia	Cathepsin B precursor	0.0297	0.3111	1
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0026	0.0013
Echinococcus multilocularis	cysteine protease	0.0178	0.1602	0.1583
Plasmodium vivax	unspecified product	0.0053	0.0026	0.0095
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.0026	0.0026
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0026	0.0026
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0053	0.0026	0.0095
Echinococcus multilocularis	cathepsin b	0.0844	1	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0081	0.0385	0.0385
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0178	0.1602	0.5113
Plasmodium falciparum	serine repeat antigen 3	0.0053	0.0026	0.0026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0103	0.0665	0.2081
Leishmania major	cathepsin L-like protease	0.0178	0.1602	0.5113
Plasmodium vivax	hypothetical protein, conserved	0.0054	0.004	0.0145
Onchocerca volvulus		0.0053	0.0026	0.0008
Trichomonas vaginalis	calcineurin B subunit, putative	0.0054	0.004	0.0058
Schistosoma mansoni	hypothetical protein	0.0316	0.3344	0.3344
Entamoeba histolytica	cysteine proteinase 2	0.0103	0.0665	0.3735
Brugia malayi	calpain 7	0.027	0.2767	0.2767
Plasmodium vivax	centrin-1, putative	0.0052	0.0022	0.008
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0026	0.0013
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.027	0.2767	0.2767
Leishmania major	cathepsin L-like protease	0.0178	0.1602	0.5113
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0081	0.0385	0.0385
Trypanosoma cruzi	cysteine proteinase, putative	0.0103	0.0665	0.0665
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0178	0.1602	0.1583
Brugia malayi	fibroinase precursor	0.0053	0.0026	0.0026
Plasmodium falciparum	serine repeat antigen 8	0.0053	0.0026	0.0026
Leishmania major	hypothetical protein, conserved	0.0081	0.0385	0.1175
Schistosoma mansoni	mitochondrial solute carrier	0.0052	0.0022	0.0022
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.1602	0.5113
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0053	0.0026	0.0095
Leishmania major	cathepsin L-like protease	0.0178	0.1602	0.5113
Plasmodium vivax	vivapain-1	0.0103	0.0665	0.2403
Plasmodium vivax	vivapain-2	0.0178	0.1602	0.5788
Trypanosoma cruzi	cruzipain precursor, putative	0.0178	0.1602	0.1602
Brugia malayi	programmed cell death protein 6	0.0052	0.0022	0.0022
Entamoeba histolytica	cysteine proteinase, putative	0.0127	0.0963	0.5466
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0053	0.0026	0.0095
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0026	0.0024
Brugia malayi	Cathepsin L-like precursor	0.0178	0.1602	0.1602
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.1175
Echinococcus granulosus	calumenin	0.0054	0.004	0.0018
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.1175
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0053	0.0026	0.0026
Echinococcus multilocularis	cysteine protease	0.0178	0.1602	0.1583
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0178	0.1602	0.5113
Trypanosoma cruzi	calmodulin, putative	0.0052	0.0022	0.0022
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0053	0.0026	0.0013
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0053	0.0026	0.0024
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.1602	0.5113
Plasmodium falciparum	calpain	0.0081	0.0385	0.2298
Brugia malayi	Cathepsin L-like precursor	0.0178	0.1602	0.1602
Trypanosoma cruzi	cysteine peptidase, putative	0.0178	0.1602	0.1602
Trichomonas vaginalis	calpain, putative	0.0081	0.0385	0.1175
Trypanosoma cruzi	programmed cell death 6 protein-like, putative	0.0052	0.0022	0.0022
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0081	0.0385	0.1175
Echinococcus multilocularis	caspase 2	0.0059	0.0106	0.0084

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 25 %	Inhibition of [3H]-CGS-21,680 binding to Adenosine A2A receptor expressed in CHO cells	ChEMBL.	15481989
Ki (binding)	= 23 nM	Displacement of [125I]-AB-MECA binding to Adenosine A3 receptor expressed in CHO cells	ChEMBL.	15481989
Ki (binding)	= 350 nM	Displacement of [3H]-CHA binding to Adenosine A1 receptor expressed in CHO cells	ChEMBL.	15481989
Ki (binding)	> 1000 nM	Displacement of [3H]-CGS-21,680 binding to Adenosine A2 receptor expressed in CHO cells	ChEMBL.	15481989
Ratio (binding)	= 15.22	Ratio of binding affinity for Adenosine A1 and Adenosine A3 receptors	ChEMBL.	15481989

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 414090

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 327322