Detailed information for compound 1352778

Basic information

Technical information
  • TDR Targets ID: 1352778
  • Name: 4-(4-chlorophenyl)-2-(4-fluorophenoxy)pyrimid ine
  • MW: 300.715 | Formula: C16H10ClFN2O
  • H donors: 0 H acceptors: 2 LogP: 4.46 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)Oc1nccc(n1)c1ccc(cc1)Cl
  • InChi: 1S/C16H10ClFN2O/c17-12-3-1-11(2-4-12)15-9-10-19-16(20-15)21-14-7-5-13(18)6-8-14/h1-10H
  • InChiKey: YZNVRCSSXIMAAC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • MLS000326845
  • SMR000179390
  • ZINC01402089
  • 8N-512S

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0038 0.0251 0.0166
Giardia lamblia Hypothetical protein 0.0108 0.1013 0.3066
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0179 0.0471
Schistosoma mansoni calpain-2 (C02 family) 0.0078 0.0685 0.0737
Echinococcus multilocularis cathepsin b 0.0855 0.9062 1
Trypanosoma cruzi cruzipain precursor, putative 0.0087 0.0788 0.0824
Mycobacterium ulcerans hypothetical protein 0.0108 0.1013 0.1028
Schistosoma mansoni hypothetical protein 0.0543 0.5696 0.6278
Plasmodium vivax aspartyl protease, putative 0.011 0.1028 0.3414
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0278 0.2842 0.8755
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0433 0.0472
Schistosoma mansoni calpain-7 (C02 family) 0.0281 0.2874 0.3157
Schistosoma mansoni hypothetical protein 0.0018 0.004 0.0024
Trichomonas vaginalis calmodulin, putative 0.0038 0.0254 0.0548
Trichomonas vaginalis calcium binding protein, putative 0.0038 0.0251 0.054
Trypanosoma cruzi cysteine peptidase, putative 0.0289 0.2957 0.323
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0433 0.0478
Brugia malayi hypothetical protein 0.0583 0.613 0.6758
Schistosoma mansoni pyruvate kinase 0.0033 0.0201 0.0202
Trichomonas vaginalis calmodulin, putative 0.0038 0.0251 0.054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0087 0.0788 0.087
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0201 0.0083
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0289 0.2957 0.9106
Echinococcus multilocularis calbindin 32 0.0038 0.0254 0.0274
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.016 0.1575 0.4789
Schistosoma mansoni microtubule-associated protein tau 0.0682 0.7197 0.7938
Echinococcus granulosus caspase 0.0212 0.2127 0.2342
Entamoeba histolytica hypothetical protein 0.0073 0.0633 0.1919
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0068 0.0068
Brugia malayi Muscle positioning protein 4 0.0053 0.042 0.0444
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0081 0.0111
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0073 0.0633 0.0698
Echinococcus granulosus centrin 2 0.0038 0.0251 0.0271
Loa Loa (eye worm) hypothetical protein 0.0073 0.0633 0.0698
Trichomonas vaginalis calmodulin, putative 0.0038 0.0251 0.054
Echinococcus granulosus Smad4 0.0016 0.0019 0.0014
Leishmania major phospholipase c-like protein 0.0038 0.0251 0.0646
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0633 0.1748
Giardia lamblia Cysteine protease 0.0073 0.0633 0.1882
Echinococcus granulosus zinc finger protein 0.0026 0.0121 0.0127
Trichomonas vaginalis peptide N-glycanase, putative 0.0108 0.1013 0.2951
Echinococcus granulosus snurportin 1 0.0316 0.325 0.3583
Onchocerca volvulus 0.0053 0.042 0.0449
Echinococcus granulosus intermediate filament protein 0.0031 0.0178 0.019
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.1065 0.1157
Entamoeba histolytica cysteine protease, putative 0.016 0.1575 0.5195
Schistosoma mansoni mitochondrial solute carrier 0.0038 0.0251 0.0257
Trypanosoma cruzi metacaspase, putative 0.014 0.1353 0.145
Trypanosoma cruzi cysteine proteinase, putative 0.016 0.1575 0.1697
Schistosoma mansoni caspase-7 (C14 family) 0.0303 0.3108 0.3416
Loa Loa (eye worm) hypothetical protein 0.0201 0.2015 0.2223
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0039 0.0262 0.0799
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Echinococcus granulosus calpain A 0.0788 0.834 0.9203
Mycobacterium tuberculosis Long conserved protein 0.0108 0.1013 0.0966
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0152 0.0147
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0201 0.0382
Mycobacterium ulcerans esterase/lipase LipP 0.0147 0.1435 0.148
Loa Loa (eye worm) hypothetical protein 0.0147 0.1435 0.1584
Schistosoma mansoni neuronal calcium sensor 0.0038 0.0251 0.0257
Schistosoma mansoni gabp alpha 0.0074 0.0642 0.069
Plasmodium vivax hypothetical protein, conserved 0.0147 0.1435 0.4803
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0201 0.0083
Echinococcus granulosus muscleblind protein 0.018 0.1791 0.1971
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0114 0.0126
Echinococcus multilocularis fat cadherin tumor suppressor 0.0053 0.042 0.0457
Echinococcus multilocularis caspase 0.0212 0.2127 0.2342
Echinococcus granulosus cathepsin l cysteine peptidase 0.0289 0.2957 0.3259
Echinococcus granulosus prolyl endopeptidase 0.0134 0.1286 0.1413
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.2957 0.9116
Schistosoma mansoni hypothetical protein 0.0053 0.042 0.0444
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0165 0.0375
Schistosoma mansoni neuronal calcium sensor 0.0038 0.0251 0.0257
Plasmodium vivax unspecified product 0.016 0.1575 0.5281
Schistosoma mansoni intermediate filament proteins 0.0031 0.0178 0.0176
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0327 0.0779
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0289 0.2957 0.9106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0855 0.0925
Brugia malayi cathepsin L precursor 0.0073 0.0633 0.0679
Echinococcus multilocularis EF hand domain containing family member A2 0.0038 0.0251 0.0271
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.014 0.1353 0.4027
Schistosoma mansoni survival motor neuron protein 0.0049 0.0369 0.0388
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0643 0.0704
Echinococcus granulosus calpain A 0.0278 0.2842 0.3131
Loa Loa (eye worm) MBCTL1 0.0062 0.0514 0.0568
Onchocerca volvulus 0.0147 0.1435 0.2147
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0855 0.0938
Schistosoma mansoni hypothetical protein 0.0108 0.1013 0.1099
Loa Loa (eye worm) beta-lactamase 0.0147 0.1435 0.1584
Schistosoma mansoni ap endonuclease 0.0038 0.0255 0.0261
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0222 0.2243 0.247
Brugia malayi notch-like transmembrane receptor 0.0053 0.042 0.0444
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.2382 0.2629
Trypanosoma brucei metacaspase MCA2 0.014 0.1353 0.4094
Plasmodium falciparum plasmepsin X 0.011 0.1028 0.3414
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0255 0.0233
Echinococcus granulosus calumenin 0.0038 0.0254 0.0274
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.004 0.0038
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.013 0.0266
Trypanosoma cruzi cysteine peptidase, putative 0.016 0.1575 0.1697
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0078 0.0685 0.071
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0152 0.0147
Giardia lamblia Cathepsin B precursor 0.0315 0.324 1
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0255 0.0552
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0179 0.0191
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.008 0.0711 0.0738
Echinococcus multilocularis smad 0.0016 0.0019 0.0014
Loa Loa (eye worm) hypothetical protein 0.055 0.5776 0.6374
Plasmodium vivax unspecified product 0.0073 0.0633 0.2063
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Schistosoma mansoni hypothetical protein 0.0018 0.004 0.0024
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0062 0.0514 0.0561
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0608 0.0652
Echinococcus granulosus pyruvate kinase 0.0017 0.0028 0.0024
Schistosoma mansoni notch 0.0053 0.042 0.0444
Onchocerca volvulus Cell death protein 3 homolog 0.0303 0.3108 0.4945
Entamoeba histolytica cysteine proteinase 2 0.016 0.1575 0.5195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.2957 0.9116
Trichomonas vaginalis calpain, putative 0.0078 0.0685 0.1914
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0212 0.2127 0.2342
Echinococcus granulosus notch 0.0053 0.042 0.0457
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0052 0.0073
Loa Loa (eye worm) hypothetical protein 0.0583 0.613 0.6764
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0289 0.2957 0.9106
Echinococcus multilocularis calumenin 0.0038 0.0254 0.0274
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0113 0.1065 0.3227
Echinococcus granulosus apoptotic protease activating factor 1 0.0163 0.1601 0.1761
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.2957 0.9116
Trichomonas vaginalis calmodulin, putative 0.0038 0.0251 0.054
Brugia malayi EGF-like domain containing protein 0.0053 0.042 0.0444
Brugia malayi cathepsin L-like precursor 0.0201 0.2015 0.2207
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0201 0.0382
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0113 0.1065 0.1131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.2957 0.9116
Giardia lamblia Cathepsin L-like protease 0.0073 0.0633 0.1882
Echinococcus multilocularis peroxidasin 0.0583 0.613 0.6762
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.2382 0.2629
Mycobacterium tuberculosis Conserved protein 0.0147 0.1435 0.1391
Toxoplasma gondii calmodulin CAM1 0.0038 0.0254 0.0702
Toxoplasma gondii centrin, putative 0.0038 0.0251 0.0695
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0078 0.0685 0.1914
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0104 0.0076
Brugia malayi fibroinase precursor 0.0073 0.0633 0.0679
Leishmania major cathepsin L-like protease 0.0289 0.2957 0.9116
Echinococcus multilocularis cysteine protease 0.0289 0.2957 0.3259
Schistosoma mansoni hypothetical protein 0.0025 0.0114 0.0106
Mycobacterium leprae conserved hypothetical protein 0.0147 0.1435 0.1341
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0278 0.2842 0.3102
Onchocerca volvulus Peroxidase homolog 0.0583 0.613 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.2957 0.9116
Trypanosoma brucei Component of motile flagella 41 0.0038 0.0251 0.0646
Echinococcus granulosus calbindin 32 0.0038 0.0254 0.0274
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0078 0.0685 0.071
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0276 0.0082
Echinococcus multilocularis importin subunit beta 1 0.003 0.0165 0.0175
Brugia malayi hypothetical protein 0.0016 0.0021 0.0002
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0165 0.0375
Schistosoma mansoni hypothetical protein 0.0543 0.5696 0.6278
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.2004
Echinococcus granulosus delta-like protein 1 0.0053 0.042 0.0457
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0199 0.022
Giardia lamblia Cysteine protease 0.0073 0.0633 0.1882
Loa Loa (eye worm) hypothetical protein 0.0289 0.2957 0.3263
Toxoplasma gondii cathepsin CPL 0.0289 0.2957 0.9121
Loa Loa (eye worm) inositol-1 0.0045 0.0327 0.0361
Plasmodium falciparum plasmepsin IV 0.0028 0.0152 0.0422
Schistosoma mansoni neuronal calcium sensor 0.0038 0.0251 0.0257
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0078 0.0685 0.1914
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.012 0.1135 0.1089
Brugia malayi Calcium binding EGF domain containing protein 0.0053 0.042 0.0444
Loa Loa (eye worm) hypothetical protein 0.0147 0.1435 0.1584
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.1435 0.1566
Loa Loa (eye worm) hypothetical protein 0.0046 0.0345 0.0381
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0401 0.0423
Trichomonas vaginalis calmodulin, putative 0.0038 0.0251 0.054
Leishmania major calpain protease-like protein 0.0078 0.0685 0.2004
Entamoeba histolytica calpain large subunit domain III containing protein 0.02 0.2002 0.668
Onchocerca volvulus 0.0147 0.1435 0.2147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0201 0.2015 0.6123
Trichomonas vaginalis calcium binding proteins, putative 0.0038 0.0251 0.054
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0278 0.2842 0.3102
Trypanosoma cruzi I/6 autoantigen, putative 0.0038 0.0251 0.0229
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0433 0.0472
Loa Loa (eye worm) hypothetical protein 0.0049 0.0376 0.0415
Brugia malayi hypothetical protein 0.0238 0.2412 0.2646
Plasmodium falciparum plasmepsin V 0.0028 0.0152 0.0422
Entamoeba histolytica cysteine proteinase, putative 0.0201 0.2015 0.6724
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0113 0.1065 0.3191
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0886 0.9404 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.046 0.0507
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0078 0.0685 0.2004
Echinococcus multilocularis geminin 0.0543 0.5696 0.6283
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0255 0.0275
Schistosoma mansoni hypothetical protein 0.0018 0.004 0.0024
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0147 0.1435 0.1391
Plasmodium falciparum serine repeat antigen 4 0.0073 0.0633 0.2063
Echinococcus multilocularis mitogen activated protein kinase 3 0.0113 0.1065 0.1169
Entamoeba histolytica calcium binding family protein 0.0038 0.0251 0.0593
Giardia lamblia Cathepsin L precursor 0.0073 0.0633 0.1882
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.071
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0081 0.0082
Trypanosoma cruzi kinesin, putative 0.02 0.2002 0.2171
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.008 0.0711 0.2191
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.014 0.1353 0.4027
Echinococcus granulosus caspase 8 0.014 0.1353 0.1487
Schistosoma mansoni cathepsin F (C01 family) 0.0201 0.2015 0.2207
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.1435 0.4288
Leishmania major hypothetical protein, conserved 0.0147 0.1435 0.4352
Mycobacterium leprae Conserved hypothetical protein 0.0108 0.1013 0.0882
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0278 0.2842 0.8755
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.008 0.0711 0.0784
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0855 0.9062 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0182
Echinococcus multilocularis programmed cell death protein 0.0041 0.0289 0.0313
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0201 0.0202
Trypanosoma cruzi kinesin, putative 0.02 0.2002 0.2171
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0201 0.0222
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0081 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0633 0.1748
Schistosoma mansoni hypothetical protein 0.0039 0.0265 0.0273
Schistosoma mansoni cpg binding protein 0.0037 0.0244 0.025
Echinococcus granulosus pyruvate kinase 0.0017 0.0028 0.0024
Loa Loa (eye worm) hypothetical protein 0.0028 0.0152 0.0167
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0788 0.8338 0.92
Brugia malayi cathepsin L-like cysteine proteinase 0.0073 0.0633 0.0679
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.2412 0.2656
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0113 0.1065 0.1131
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0028 0.0152 0.0225
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.004 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0633 0.1748
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0081 0.0163
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0201 0.015
Echinococcus granulosus caspase 2 0.0303 0.3108 0.3425
Onchocerca volvulus Chorion peroxidase homolog 0.0583 0.613 1
Trichomonas vaginalis conserved hypothetical protein 0.014 0.1353 0.4027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0289 0.2957 0.9106
Leishmania major metacaspase, putative 0.014 0.1353 0.4094
Schistosoma mansoni centrin-related 0.0038 0.0251 0.0257
Toxoplasma gondii troponin c, isotype gamma, putative 0.0038 0.0251 0.0695
Trichomonas vaginalis calcium binding protein, putative 0.0038 0.0251 0.054
Trypanosoma brucei mitochondrial calcium uptake 1 0.0038 0.0251 0.0646
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0073 0.0633 0.2063
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.0633 0.0679
Loa Loa (eye worm) hypothetical protein 0.0025 0.0117 0.0129
Trichomonas vaginalis calcineurin B subunit, putative 0.0038 0.0254 0.0548
Schistosoma mansoni importin beta-1 0.003 0.0165 0.0162
Mycobacterium tuberculosis Conserved hypothetical protein 0.0108 0.1013 0.0966
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0255 0.0774
Echinococcus multilocularis notch 0.0053 0.042 0.0457
Trypanosoma brucei cysteine peptidase, putative 0.0078 0.0685 0.2004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0152 0.0147
Echinococcus multilocularis pyruvate kinase 0.0033 0.0201 0.0215
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0117 0.0079
Onchocerca volvulus 0.0031 0.0178 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0073 0.0633 0.1748
Echinococcus granulosus protein jagged 1 0.0053 0.042 0.0457
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0855 0.9062 1
Trypanosoma brucei calpain-like protein, putative 0.0278 0.2842 0.8755
Loa Loa (eye worm) hypothetical protein 0.0201 0.2015 0.2223
Loa Loa (eye worm) calpain family protein 1 0.055 0.5776 0.6374
Schistosoma mansoni calpain-7 (C02 family) 0.0281 0.2874 0.3157
Echinococcus granulosus EF hand domain containing family member A2 0.0038 0.0254 0.0274
Echinococcus multilocularis lamin 0.0031 0.0178 0.019
Brugia malayi Proteasome A-type and B-type family protein 0.008 0.0711 0.0765
Trichomonas vaginalis calmodulin, putative 0.0041 0.0289 0.0661
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0327 0.0856
Entamoeba histolytica calmodulin, putative 0.0038 0.0251 0.0593
Echinococcus multilocularis calmodulin 0.0038 0.0251 0.0271
Loa Loa (eye worm) aspartyl protease 6 0.0028 0.0152 0.0167
Echinococcus granulosus neuronal calcium sensor 0.0038 0.0251 0.0271
Brugia malayi Cathepsin L-like precursor 0.0201 0.2015 0.2207
Schistosoma mansoni caspase-7 (C14 family) 0.0212 0.2127 0.2331
Brugia malayi Blistered cuticle protein 3 0.0583 0.613 0.6758
Echinococcus multilocularis pyruvate kinase 0.0033 0.0201 0.0215
Echinococcus granulosus calpain 5 0.0278 0.2842 0.3131
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.0633 0.0679
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Plasmodium falciparum plasmepsin I 0.0028 0.0152 0.0422
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0052 0.0036
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0255 0.0552
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0052 0.005
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0433 0.0458
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.1065 0.3115
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0855 0.0938
Schistosoma mansoni hypothetical protein 0.0053 0.042 0.0444
Leishmania major calmodulin, putative 0.0038 0.0251 0.0646
Mycobacterium tuberculosis Probable hydrolase 0.0147 0.1435 0.1391
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0078 0.0685 0.071
Echinococcus granulosus Transglutaminase 0.0108 0.1013 0.1112
Plasmodium falciparum proteasome subunit beta type-5 0.008 0.0711 0.233
Brugia malayi calpain 5 0.0078 0.0685 0.0737
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0052 0.0073
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0278 0.2842 0.3102
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0081 0.0179
Onchocerca volvulus 0.0049 0.0369 0.0364
Trichomonas vaginalis conserved hypothetical protein 0.014 0.1353 0.4027
Loa Loa (eye worm) cathepsin B 0.0315 0.324 0.3575
Toxoplasma gondii EF hand domain-containing protein 0.0038 0.0251 0.0695
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0113 0.1065 0.1131
Onchocerca volvulus 0.0147 0.1435 0.2147
Entamoeba histolytica Flap nuclease, putative 0.0026 0.013 0.0172
Brugia malayi Bromodomain containing protein 0.0046 0.0345 0.036
Trypanosoma brucei centrin, putative 0.0038 0.0251 0.0646
Onchocerca volvulus 0.0201 0.2015 0.3117
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0073 0.0633 0.1882
Trypanosoma cruzi metacaspase, putative 0.014 0.1353 0.145
Plasmodium vivax importin-beta 2, putative 0.003 0.0165 0.0466
Onchocerca volvulus 0.0033 0.0199 0.008
Echinococcus granulosus neurocalcin 0.0038 0.0251 0.0271
Echinococcus granulosus cysteine protease 0.016 0.1575 0.1733
Trypanosoma cruzi cysteine peptidase, putative 0.0289 0.2957 0.323
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0433 0.0472
Onchocerca volvulus Prolyl endopeptidase homolog 0.0134 0.1286 0.1897
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.2957 0.9116
Loa Loa (eye worm) hypothetical protein 0.018 0.1791 0.1976
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0073 0.0633 0.0698
Brugia malayi aspartic protease BmAsp-2, identical 0.0028 0.0152 0.0147
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0278 0.2842 0.8755
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.075 0.7932 0.8751
Onchocerca volvulus 0.0289 0.2957 0.4693
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0278 0.2842 0.3102
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0788 0.8338 0.9199
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0327 0.093
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0052 0.005
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0327 0.0779
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0073 0.0633 0.2063
Giardia lamblia Cysteine protease 0.0073 0.0633 0.1882
Schistosoma mansoni notch 0.0053 0.042 0.0444
Entamoeba histolytica hypothetical protein 0.0038 0.0251 0.0592
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0073 0.0633 0.0679
Echinococcus multilocularis cathepsin L 0.0073 0.0633 0.0692
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.014 0.1353 0.4027
Mycobacterium tuberculosis Conserved protein 0.0147 0.1435 0.1391
Giardia lamblia Cathepsin L precursor 0.0073 0.0633 0.1882
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.014 0.1353 0.1475
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0315 0.324 1
Brugia malayi Animal haem peroxidase family protein 0.0583 0.613 0.6758
Onchocerca volvulus 0.0583 0.613 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0087 0.0788 0.0851
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.2957 0.9116
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0038 0.0251 0.0229
Schistosoma mansoni hypothetical protein 0.0038 0.0251 0.0257
Trypanosoma cruzi conserved protein 0.0078 0.0685 0.071
Loa Loa (eye worm) hypothetical protein 0.0147 0.1435 0.1584
Loa Loa (eye worm) Smad1 0.0016 0.0019 0.0021
Plasmodium falciparum pyruvate kinase 0.0033 0.0201 0.0591
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0104 0.0076
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0068 0.0054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0289 0.2957 0.9106
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.1435 0.1542
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0251 0.027
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.1065 0.3115
Loa Loa (eye worm) hypothetical protein 0.0087 0.0788 0.087
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0327 1
Trypanosoma brucei I/6 autoantigen 0.0038 0.0251 0.0646
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0278 0.2842 0.3102
Leishmania major cathepsin L-like protease 0.0289 0.2957 0.9116
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0327 0.0779
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0073 0.0633 0.2063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0179 0.0178
Trypanosoma cruzi oligopeptidase b 0.0053 0.0418 0.0414
Onchocerca volvulus Cathepsin F homolog 0.0289 0.2957 0.4693
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0147 0.1435 0.1391
Trypanosoma brucei prolyl endopeptidase 0.0134 0.1286 0.3884
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.014 0.1353 0.4027
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.016 0.017
Mycobacterium ulcerans transglutaminase family protein 0.0108 0.1013 0.1028
Brugia malayi Cathepsin L-like precursor 0.0289 0.2957 0.3249
Echinococcus multilocularis muscleblind protein 1 0.018 0.1791 0.1971
Echinococcus granulosus EF hand domain containing family member A2 0.0038 0.0251 0.0271
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.2004
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.1065 0.3115
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0081 0.0163
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0855 0.0938
Giardia lamblia Kinase, CMGC MAPK 0.0113 0.1065 0.3227
Echinococcus multilocularis cathepsin L 0.016 0.1575 0.1733
Loa Loa (eye worm) fibroinase 0.0289 0.2957 0.3263
Echinococcus granulosus calpain 0.0278 0.2842 0.3131
Leishmania major i/6 autoantigen-like protein 0.0038 0.0251 0.0646
Brugia malayi Papain family cysteine protease containing protein 0.016 0.1575 0.1721
Trypanosoma cruzi metacaspase 5, putative 0.014 0.1353 0.145
Echinococcus multilocularis neurogenic locus protein delta 0.0053 0.042 0.0457
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.2004
Trypanosoma brucei metacaspase MCA3 0.014 0.1353 0.4094
Onchocerca volvulus Cathepsin L homolog 0.0073 0.0633 0.0804
Schistosoma mansoni ef hand domain family member A2 0.0038 0.0251 0.0257
Schistosoma mansoni peroxidasin 0.0583 0.613 0.6758
Echinococcus multilocularis calmodulin 0.0038 0.0251 0.0271
Echinococcus granulosus peroxidasin 0.0583 0.613 0.6762
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Echinococcus multilocularis cysteine protease 0.0289 0.2957 0.3259
Trichomonas vaginalis calpain, putative 0.0078 0.0685 0.1914
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0073 0.0633 0.2063
Loa Loa (eye worm) calmodulin-like protein 0.0038 0.0251 0.0277
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0152 0.0147
Loa Loa (eye worm) hypothetical protein 0.0583 0.613 0.6764
Brugia malayi calpain family protein 1 0.075 0.7932 0.8751
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.1435 0.1542
Leishmania major hypothetical protein, conserved 0.0038 0.0254 0.0653
Echinococcus granulosus pyruvate kinase 0.0017 0.0028 0.0024
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0327 0.0354
Brugia malayi EGF-like domain containing protein 0.0053 0.042 0.0444
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0053 0.0418 0.0369
Loa Loa (eye worm) calpain 0.0278 0.2842 0.3136
Trypanosoma brucei kinesin, putative 0.02 0.2002 0.6127
Entamoeba histolytica cysteine protease, putative 0.0073 0.0633 0.1919
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0178 0.0196
Loa Loa (eye worm) hypothetical protein 0.003 0.0172 0.019
Echinococcus granulosus cathepsin L cysteine protease 0.016 0.1575 0.1733
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.016 0.0169
Echinococcus multilocularis pyruvate kinase 0.0017 0.0028 0.0024
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.016 0.1575 0.1721
Loa Loa (eye worm) hypothetical protein 0.0238 0.2412 0.2661
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.004 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.016 0.1575 0.4731
Mycobacterium tuberculosis Conserved hypothetical protein 0.0108 0.1013 0.0966
Brugia malayi MH2 domain containing protein 0.0235 0.2382 0.2613
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0289 0.2957 0.9106
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.013 0.0144
Echinococcus granulosus tumor protein p63 0.0351 0.3636 0.4008
Entamoeba histolytica cysteine protease, putative 0.0073 0.0633 0.1919
Echinococcus multilocularis Smad4 0.0016 0.0019 0.0014
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.016 0.1575 0.1721
Schistosoma mansoni pyruvate kinase 0.0033 0.0201 0.0202
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0327 0.0882
Brugia malayi MAP kinase sur-1 0.0113 0.1065 0.1157
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0251 0.0257
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0327 0.0882
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.013 0.0317
Brugia malayi Latrophilin receptor protein 2 0.0018 0.004 0.0024
Echinococcus granulosus cathepsin L cysteine proteinase 0.0289 0.2957 0.3259
Giardia lamblia Hypothetical protein 0.0038 0.0254 0.0702
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0053 0.0418 0.0236
Echinococcus granulosus fibropellin Ia 0.0053 0.042 0.0457
Echinococcus granulosus neurogenic locus notch protein 0.0053 0.042 0.0457
Echinococcus multilocularis EF hand domain containing family member A2 0.0038 0.0254 0.0274
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0078 0.0685 0.2046
Schistosoma mansoni ran 0.0022 0.0081 0.0068
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0078 0.0685 0.1914
Leishmania major programmed cell death 6 protein-like protein 0.0038 0.0251 0.0646
Loa Loa (eye worm) hypothetical protein 0.0051 0.0401 0.0442
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0073 0.0633 0.2063
Echinococcus multilocularis neurogenic locus notch protein 4 0.0053 0.042 0.0457
Echinococcus multilocularis flap endonuclease 1 0.0026 0.013 0.0137
Trypanosoma brucei Calpain-like protein CALP1.3 0.0078 0.0685 0.2004
Plasmodium falciparum plasmepsin VIII, putative 0.0028 0.0152 0.0422
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0038 0.0251 0.0229
Echinococcus multilocularis neurocalcin 0.0038 0.0251 0.0271
Echinococcus multilocularis neural cadherin 0.0053 0.042 0.0457
Brugia malayi intermediate filament protein 0.0031 0.0178 0.0176
Schistosoma mansoni notch 0.0053 0.042 0.0444
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0788 0.8338 0.92
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.046 0.0488
Schistosoma mansoni cpg binding protein 0.0033 0.0199 0.02
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0855 0.0938
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0038 0.0251 0.0271
Entamoeba histolytica cysteine proteinase, putative 0.016 0.1575 0.5195
Trichomonas vaginalis calcium binding protein, putative 0.0038 0.0251 0.054
Echinococcus multilocularis neuronal calcium sensor 0.0038 0.0251 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0289 0.2957 0.9106
Toxoplasma gondii cathepsin CPC1 0.0073 0.0633 0.1882
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0633 0.1748
Leishmania major cathepsin L-like protease 0.0289 0.2957 0.9116
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.1435 0.4288
Echinococcus multilocularis slit 2 protein 0.0053 0.042 0.0457
Entamoeba histolytica cysteine protease, putative 0.016 0.1575 0.5195
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Brugia malayi programmed cell death protein 6 0.0038 0.0251 0.0257
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.2004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.0633 0.0679
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0073 0.0633 0.2063
Entamoeba histolytica cysteine protease, putative 0.016 0.1575 0.5195
Echinococcus granulosus slit 2 protein 0.0053 0.042 0.0457
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0201 0.0173
Onchocerca volvulus Neurogenic locus notch homolog 0.0053 0.042 0.0449
Brugia malayi calpain 7 0.0278 0.2842 0.3122
Leishmania major cytochrome p450-like protein 0.0019 0.0051 0.0019
Brugia malayi Thioredoxin family protein 0.0108 0.1013 0.1099
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0251 0.054
Echinococcus multilocularis calpain 5 0.0278 0.2842 0.3131
Mycobacterium ulcerans proteasome PrcB 0.008 0.0711 0.0705
Onchocerca volvulus 0.0054 0.0433 0.0471
Schistosoma mansoni hypothetical protein 0.0053 0.042 0.0444
Leishmania major GTP-binding protein, putative 0.0022 0.0081 0.0111
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0147 0.1435 0.148
Brugia malayi cathepsin Z-like cysteine proteinase 0.0073 0.0633 0.0679
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0028 0.0152 0.0385
Toxoplasma gondii preprocathepsin c precursor, putative 0.0073 0.0633 0.1882
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0212 0.2127 0.2342
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0433 0.0458
Schistosoma mansoni laminin gamma-3 chain 0.0053 0.042 0.0444
Brugia malayi Eukaryotic aspartyl protease family protein 0.0028 0.0152 0.0147
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0073 0.0633 0.2063
Schistosoma mansoni cathepsin S (C01 family) 0.0073 0.0633 0.0679
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0053 0.0418 0.0414
Loa Loa (eye worm) hypothetical protein 0.0023 0.0094 0.0103
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0073 0.0633 0.1882
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0289 0.2957 0.9106
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0316 0.325 0.3587
Brugia malayi Cathepsin L-like precursor 0.0201 0.2015 0.2207
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0643 0.0704
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0052 0.005
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0078 0.0685 0.1914
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0278 0.2842 0.3102
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.016 0.0177
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.2004
Schistosoma mansoni zinc finger protein 0.0026 0.0121 0.0113
Trichomonas vaginalis hypothetical protein 0.0078 0.0685 0.1914
Entamoeba histolytica cysteine protease, putative 0.0073 0.0633 0.1919
Schistosoma mansoni hypothetical protein 0.0163 0.1601 0.175
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0073 0.0633 0.1882
Loa Loa (eye worm) hypothetical protein 0.0583 0.613 0.6764
Loa Loa (eye worm) hypothetical protein 0.0052 0.0401 0.0443
Echinococcus multilocularis apoptotic protease activating factor 1 0.0163 0.1601 0.1761
Echinococcus granulosus smad 0.0016 0.0019 0.0014
Loa Loa (eye worm) hypothetical protein 0.0583 0.613 0.6764
Echinococcus granulosus programmed cell death protein 0.0041 0.0289 0.0313
Giardia lamblia Cathepsin L-like protease 0.0073 0.0633 0.1882
Echinococcus granulosus cathepsin L 0.016 0.1575 0.1733
Loa Loa (eye worm) EF hand family protein 0.0038 0.0251 0.0277
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0255 0.0281
Entamoeba histolytica cysteine protease, putative 0.0073 0.0633 0.1919
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0051 0.0056
Schistosoma mansoni Mername-AA248 (C02 family) 0.0278 0.2842 0.3122
Loa Loa (eye worm) hypothetical protein 0.075 0.7932 0.8753
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0052 0.005
Schistosoma mansoni calmodulin 0.0038 0.0251 0.0257
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0327 0.0312
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.2004
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0078 0.0685 0.071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0201 0.2015 0.6123
Brugia malayi Peroxidasin 0.0583 0.613 0.6758
Schistosoma mansoni cpg binding protein 0.0037 0.0244 0.025
Loa Loa (eye worm) notch protein 0.0053 0.042 0.0464
Plasmodium falciparum centrin-1 0.0038 0.0251 0.0761
Brugia malayi beta-lactamase 0.0147 0.1435 0.1566
Brugia malayi calpain D 0.0078 0.0685 0.0737
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Trypanosoma brucei calpain, putative 0.0078 0.0685 0.2004
Brugia malayi Papain family cysteine protease containing protein 0.016 0.1575 0.1721
Giardia lamblia Transglutaminase/protease, putative 0.0108 0.1013 0.3066
Entamoeba histolytica cysteine protease, putative 0.016 0.1575 0.5195
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0051 0.0019
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0073 0.0633 0.2063
Schistosoma mansoni hypothetical protein 0.0018 0.0045 0.0029
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0073 0.0633 0.0679
Loa Loa (eye worm) hypothetical protein 0.0583 0.613 0.6764
Trichomonas vaginalis set domain proteins, putative 0.0241 0.2439 0.7467
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0073 0.0633 0.1748
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0078 0.0685 0.071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0633 0.1748
Trypanosoma brucei hypothetical protein 0.0078 0.0685 0.2004
Leishmania major cathepsin L-like protease 0.0289 0.2957 0.9116
Loa Loa (eye worm) animal heme peroxidase 0.0583 0.613 0.6764
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.008 0.0711 0.1995
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0113 0.1065 0.1175
Mycobacterium ulcerans proteasome PrcA 0.0886 0.9404 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0152 0.0167
Plasmodium falciparum plasmepsin VII 0.0028 0.0152 0.0422
Entamoeba histolytica cysteine protease, putative 0.016 0.1575 0.5195
Schistosoma mansoni inositol monophosphatase 0.0045 0.0327 0.0341
Schistosoma mansoni calpain (C02 family) 0.0278 0.2842 0.3122
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0019 0.0014
Echinococcus multilocularis zinc finger protein 0.0026 0.0121 0.0127
Echinococcus multilocularis cathepsin b 0.0855 0.9062 1
Plasmodium falciparum plasmepsin II 0.0028 0.0152 0.0422
Echinococcus granulosus neurogenic locus notch protein 0.0053 0.042 0.0457
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0028 0.0152 0.0167
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0073 0.0633 0.0698
Entamoeba histolytica cysteine protease, putative 0.0289 0.2957 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.071
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0038 0.0251 0.0593
Onchocerca volvulus 0.0289 0.2957 0.4693
Schistosoma mansoni cathepsin s 0.0087 0.0788 0.0851
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Schistosoma mansoni slit 0.0053 0.042 0.0444
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0038 0.0251 0.054
Echinococcus granulosus pyruvate kinase 0.0033 0.0201 0.0215
Brugia malayi hypothetical protein 0.0038 0.0251 0.0257
Brugia malayi Cell death protein 3 precursor 0.0303 0.3108 0.3416
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.2004
Mycobacterium leprae Conserved hypothetical protein 0.0108 0.1013 0.0882
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0855 0.0925
Loa Loa (eye worm) hypothetical protein 0.0147 0.1435 0.1584
Loa Loa (eye worm) hypothetical protein 0.0038 0.0251 0.0277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.016 0.1575 0.4731
Schistosoma mansoni ets-related 0.0224 0.2264 0.2483
Echinococcus multilocularis calpain family protein 1, d 0.055 0.5776 0.6371
Schistosoma mansoni hypothetical protein 0.0038 0.0251 0.0257
Echinococcus multilocularis mitogen activated protein kinase 0.0113 0.1065 0.1169
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0076 0.0084
Trypanosoma cruzi centrin, putative 0.0041 0.0289 0.0271
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0081 0.0039
Entamoeba histolytica cysteine protease, putative 0.0073 0.0633 0.1919
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.2004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0855 0.0925
Trypanosoma cruzi metacaspase 5, putative 0.014 0.1353 0.145
Brugia malayi Calcium binding EGF domain containing protein 0.0053 0.042 0.0444
Loa Loa (eye worm) hypothetical protein 0.014 0.1353 0.1493
Schistosoma mansoni myelin transcription factor 1 myt1 0.0062 0.0514 0.0548
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.071
Loa Loa (eye worm) programmed cell death protein 6 0.0038 0.0254 0.028
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Onchocerca volvulus 0.0051 0.0401 0.0416
Giardia lamblia Cathepsin B precursor 0.0073 0.0633 0.1882
Schistosoma mansoni hypothetical protein 0.0018 0.004 0.0024
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0255 0.0774
Echinococcus granulosus neurogenic locus notch protein 4 0.0053 0.042 0.0457
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0178 0.0176
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0052 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0685 0.1914
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Schistosoma mansoni lamin 0.0031 0.0178 0.0176
Entamoeba histolytica cysteine proteinase 1, putative 0.016 0.1575 0.5195
Trypanosoma brucei calpain-like protein, putative 0.0278 0.2842 0.8755
Loa Loa (eye worm) hypothetical protein 0.0583 0.613 0.6764
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0433 0.0472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0289 0.2957 0.9106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.2957 0.9116
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0104 0.0066
Brugia malayi Cytochrome P450 family protein 0.0029 0.016 0.0156
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0117 0.0302
Brugia malayi EGF-like domain containing protein 0.0053 0.042 0.0444
Echinococcus granulosus cathepsin L 0.0073 0.0633 0.0692
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.2957 0.9116
Loa Loa (eye worm) cysteine protease 0.0289 0.2957 0.3263
Mycobacterium ulcerans putative transglutaminase-like protein 0.0108 0.1013 0.1028
Brugia malayi Importin beta-1 subunit 0.003 0.0165 0.0162
Trypanosoma cruzi prolyl endopeptidase 0.0134 0.1286 0.1376
Plasmodium vivax metacaspase 1, putative 0.014 0.1353 0.4522
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0039 0.0262 0.068
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0265 0.0273
Echinococcus granulosus pyruvate kinase 0.0033 0.0201 0.0215
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.008 0.0711 0.0738
Brugia malayi Fli-1 protein 0.0224 0.2264 0.2483
Schistosoma mansoni hypothetical protein 0.0049 0.0369 0.0388
Echinococcus multilocularis calcium uptake protein 1 0.0038 0.0254 0.0274
Trypanosoma cruzi cysteine peptidase, putative 0.0087 0.0788 0.0824
Trypanosoma brucei cysteine peptidase C (CPC) 0.0315 0.324 1
Onchocerca volvulus 0.0038 0.0251 0.0166
Schistosoma mansoni lamin 0.0031 0.0178 0.0176
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0039 0.0262 0.0241
Plasmodium vivax serine-repeat antigen (SERA) 0.0073 0.0633 0.2063
Brugia malayi aspartic protease BmAsp-1, identical 0.0028 0.0152 0.0147
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.014 0.1353 0.1475
Schistosoma mansoni peroxidasin 0.0583 0.613 0.6758
Echinococcus multilocularis caspase 3 0.0072 0.062 0.0678
Leishmania major cathepsin L-like protease 0.0289 0.2957 0.9116
Toxoplasma gondii EGF family domain-containing protein 0.0053 0.042 0.122
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0289 0.2957 0.9106
Mycobacterium tuberculosis Probable esterase LipL 0.0147 0.1435 0.1391
Toxoplasma gondii centrin 0.0038 0.0251 0.0695
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.0222
Echinococcus multilocularis centrin 2 0.0038 0.0251 0.0271
Loa Loa (eye worm) hypothetical protein 0.0031 0.0178 0.0196
Trypanosoma cruzi metacaspase, putative 0.014 0.1353 0.145
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.2004
Brugia malayi Delta serrate ligand family protein 0.0053 0.042 0.0444
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.013 0.0348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0289 0.2957 0.9106
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0201 0.0202
Loa Loa (eye worm) hypothetical protein 0.0583 0.613 0.6764
Brugia malayi Cytochrome P450 family protein 0.0019 0.0051 0.0036
Echinococcus granulosus neural cadherin 0.0053 0.042 0.0457
Trypanosoma cruzi calmodulin, putative 0.0038 0.0251 0.0229
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.014 0.1353 0.4124
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0019 0.0014
Plasmodium falciparum cysteine proteinase falcipain 1 0.016 0.1575 0.5281
Schistosoma mansoni rab 0.0038 0.0251 0.0257
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.2004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0633 0.1748
Brugia malayi EGF-like domain containing protein 0.0053 0.042 0.0444
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0251 0.027
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.071
Trypanosoma cruzi oligopeptidase b 0.0053 0.0418 0.0414
Schistosoma mansoni centrin 0.0038 0.0251 0.0257
Mycobacterium tuberculosis Conserved protein 0.0108 0.1013 0.0966
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0276 0.0226
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0094 0.0046
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0255 0.0706
Leishmania major centrin, putative 0.0038 0.0251 0.0646
Leishmania major pyruvate kinase 0.0033 0.0201 0.0489
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0078 0.0685 0.0756
Loa Loa (eye worm) hypothetical protein 0.0583 0.613 0.6764
Onchocerca volvulus 0.0289 0.2957 0.4693
Schistosoma mansoni ap endonuclease 0.0038 0.0255 0.0261
Echinococcus multilocularis lamin dm0 0.0031 0.0178 0.019
Loa Loa (eye worm) hypothetical protein 0.018 0.1791 0.1976
Echinococcus granulosus flap endonuclease 1 0.0026 0.013 0.0137
Leishmania major hypothetical protein, conserved 0.0078 0.0685 0.2004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0179 0.0178
Loa Loa (eye worm) hypothetical protein 0.0039 0.0265 0.0293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.016 0.1575 0.4789
Loa Loa (eye worm) blistered cuticle protein 3 0.0583 0.613 0.6764
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0052 0.002
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0117 0.0224
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0052 0.005
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0788 0.8338 0.9199
Brugia malayi Papain family cysteine protease containing protein 0.0289 0.2957 0.3249
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0315 0.324 0.3562
Onchocerca volvulus 0.0289 0.2957 0.4693
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0633 0.1748
Leishmania major centrin, putative,caltractin, putative 0.0038 0.0251 0.0646
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0019 0.0014
Loa Loa (eye worm) hypothetical protein 0.0073 0.0633 0.0698
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0251 0.054
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0073 0.0633 0.1882
Brugia malayi hypothetical protein 0.0028 0.0152 0.0147
Plasmodium vivax plasmepsin V, putative 0.0028 0.0152 0.0422
Plasmodium vivax proteasome subunit beta type-5, putative 0.008 0.0711 0.233
Loa Loa (eye worm) hypothetical protein 0.0583 0.613 0.6764
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0289 0.2957 0.9106
Giardia lamblia Cathepsin L precursor 0.0073 0.0633 0.1882
Echinococcus multilocularis cathepsin L cysteine protease 0.0289 0.2957 0.3259
Mycobacterium ulcerans hypothetical protein 0.0108 0.1013 0.1028
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.1435 0.4288
Echinococcus granulosus lamin 0.0031 0.0178 0.019
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.071
Plasmodium vivax hypothetical protein, conserved 0.014 0.1353 0.4522
Echinococcus multilocularis prolyl endopeptidase 0.0134 0.1286 0.1413
Plasmodium vivax centrin-1, putative 0.0038 0.0251 0.0761
Onchocerca volvulus Cathepsin L homolog 0.0289 0.2957 0.4693
Schistosoma mansoni cathepsin B (C01 family) 0.0073 0.0633 0.0679
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0073 0.0633 0.2063
Schistosoma mansoni cathepsin C 0.0073 0.0633 0.0679
Echinococcus granulosus neurogenic locus protein delta 0.0053 0.042 0.0457
Echinococcus multilocularis calpain 0.0278 0.2842 0.3131
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0289 0.2957 0.3259
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0053 0.042 0.0444
Leishmania major cathepsin L-like protease 0.0289 0.2957 0.9116
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0147 0.1435 0.1566
Trypanosoma brucei centrin-3 0.0041 0.0289 0.0765
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.2004
Trichomonas vaginalis esterase, putative 0.0147 0.1435 0.4288
Echinococcus multilocularis neurogenic locus notch protein 0.0053 0.042 0.0457
Onchocerca volvulus 0.0031 0.0178 0.0044
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0255 0.0657
Brugia malayi Cathepsin L-like precursor 0.0289 0.2957 0.3249
Entamoeba histolytica cysteine protease, putative 0.0073 0.0633 0.1919
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0152 0.0147
Echinococcus multilocularis musashi 0.0031 0.0178 0.019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0289 0.2957 0.9106
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0855 0.9062 1
Toxoplasma gondii aspartyl protease ASP3 0.011 0.1028 0.3114
Loa Loa (eye worm) hypothetical protein 0.0087 0.0788 0.087
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0051 0.0056
Plasmodium vivax serine-repeat antigen (SERA) 0.0073 0.0633 0.2063
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0134 0.1286 0.1401
Schistosoma mansoni calmodulin 0.0038 0.0251 0.0257
Echinococcus granulosus protein jagged 2 0.0053 0.042 0.0457
Schistosoma mansoni caspase-3 (C14 family) 0.0212 0.2127 0.2331
Brugia malayi Flap endonuclease-1 0.0026 0.013 0.0123
Loa Loa (eye worm) hypothetical protein 0.0147 0.1435 0.1584
Brugia malayi Ets-domain containing protein 0.0074 0.0642 0.069
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0052 0.0057
Echinococcus multilocularis tumor protein p63 0.0351 0.3636 0.4008
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0073 0.0633 0.0679
Schistosoma mansoni hypothetical protein 0.0038 0.0251 0.0257
Schistosoma mansoni notch 0.0053 0.042 0.0444
Loa Loa (eye worm) hypothetical protein 0.0087 0.0788 0.087
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0052 0.005
Trypanosoma cruzi metacaspase, putative 0.014 0.1353 0.145
Echinococcus multilocularis microtubule associated protein 2 0.0682 0.7197 0.7941
Giardia lamblia Cathepsin B precursor 0.0315 0.324 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0073 0.0633 0.1748
Echinococcus granulosus cpg binding protein 0.0037 0.0244 0.0263
Onchocerca volvulus 0.0583 0.613 1
Entamoeba histolytica calmodulin, putative 0.0038 0.0251 0.0593
Brugia malayi cathepsin Z-like cysteine proteinase 0.0073 0.0633 0.0679
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0152 0.0147
Leishmania major centrin, putative 0.0038 0.0251 0.0646
Brugia malayi Pepsin A precursor 0.0028 0.0152 0.0147
Loa Loa (eye worm) hypothetical protein 0.0054 0.0433 0.0478
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0078 0.0685 0.1914
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0038 0.0254 0.026
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0315 0.324 0.3543
Leishmania major calmodulin, putative 0.0038 0.0251 0.0646
Brugia malayi Cathepsin L-like precursor 0.0289 0.2957 0.3249
Plasmodium falciparum metacaspase 1 0.014 0.1353 0.4522
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0201 0.0489
Brugia malayi Ets-domain containing protein 0.0074 0.0642 0.069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0289 0.2957 0.9106
Trypanosoma brucei caltractin, putative 0.0041 0.0289 0.0765
Leishmania major protein kinase, putative 0.0039 0.0262 0.068
Leishmania major calpain family cysteine protease-like protein 0.0078 0.0685 0.2004
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0038 0.0251 0.0257
Loa Loa (eye worm) hypothetical protein 0.0073 0.0633 0.0698
Trypanosoma brucei Calpain-like protein 1.1 0.0078 0.0685 0.2004
Onchocerca volvulus Peroxidasin homolog 0.0583 0.613 1
Entamoeba histolytica cysteine protease, putative 0.016 0.1575 0.5195
Echinococcus multilocularis proteasome (prosome, macropain) 0.008 0.0711 0.0778
Loa Loa (eye worm) hypothetical protein 0.0134 0.1286 0.1419
Trichomonas vaginalis calmodulin-2, putative 0.0038 0.0251 0.054
Onchocerca volvulus 0.0289 0.2957 0.4693
Entamoeba histolytica protein kinase, putative 0.0201 0.2013 0.6718
Schistosoma mansoni reticulocalbin 0.0038 0.0251 0.0257
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0078 0.0685 0.071
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0052 0.0007
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0278 0.2842 0.3102
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0289 0.2957 0.3259
Loa Loa (eye worm) Notch2 0.0053 0.042 0.0464
Brugia malayi hypothetical protein 0.0163 0.1601 0.175
Loa Loa (eye worm) fli-1 protein 0.0224 0.2264 0.2498
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0062 0.0514 0.0561
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0038 0.0251 0.0593
Brugia malayi EGF-like domain containing protein 0.0053 0.042 0.0444
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0278 0.2842 0.8755
Schistosoma mansoni bromodomain containing protein 0.0078 0.069 0.0742
Mycobacterium ulcerans hypothetical protein 0.0147 0.1435 0.148
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0401 0.0423
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0053 0.042 0.0449
Brugia malayi Papain family cysteine protease containing protein 0.0073 0.0633 0.0679
Leishmania major hypothetical protein, conserved 0.0038 0.0251 0.0646
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0289 0.2957 0.9106
Giardia lamblia Cathepsin L precursor 0.0073 0.0633 0.1882
Echinococcus granulosus calpain 7 C02 family 0.0278 0.2842 0.3131
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0028 0.0152 0.0161
Trypanosoma cruzi cysteine peptidase, putative 0.0289 0.2957 0.323
Schistosoma mansoni inositol monophosphatase 0.0045 0.0327 0.0341
Trypanosoma cruzi I/6 autoantigen, putative 0.0038 0.0251 0.0229
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0094 0.0103
Plasmodium vivax aspartyl proteinase, putative 0.0028 0.0152 0.0422
Brugia malayi Inositol-1 0.0045 0.0327 0.0341
Plasmodium falciparum serine repeat antigen 1 0.0073 0.0633 0.2063
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0152 0.0147
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0073 0.0633 0.1919
Entamoeba histolytica cysteine protease, putative 0.016 0.1575 0.5195
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.014 0.1353 0.4027
Giardia lamblia Cathepsin L precursor 0.0073 0.0633 0.1882
Toxoplasma gondii cathepsin CPC2 0.0073 0.0633 0.1882
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0052 0.002
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.2004
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0255 0.0275
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.0633 0.0679
Loa Loa (eye worm) hypothetical protein 0.0028 0.0152 0.0167
Loa Loa (eye worm) hypothetical protein 0.0583 0.613 0.6764
Echinococcus multilocularis programmed cell death protein 0.0041 0.0289 0.0313
Brugia malayi Animal haem peroxidase family protein 0.0583 0.613 0.6758
Brugia malayi beta-lactamase family protein 0.0147 0.1435 0.1566
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.1435 0.1566
Echinococcus granulosus cathepsin b 0.0855 0.9062 1
Brugia malayi RNA, U transporter 1 0.0084 0.0753 0.0812
Plasmodium vivax aspartyl proteinase, putative 0.0028 0.0152 0.0422
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0081 0.0082
Echinococcus granulosus EF HAND 1 calcium binding site 0.0038 0.0251 0.0271
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0289 0.2957 0.9106
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0073 0.0633 0.1748
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0052 0.008
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.004 0.0044
Loa Loa (eye worm) hypothetical protein 0.0672 0.7093 0.7827
Echinococcus multilocularis fibropellin Ia 0.0053 0.042 0.0457
Trichomonas vaginalis conserved hypothetical protein 0.014 0.1353 0.4027
Trichomonas vaginalis myosin light chain 1, putative 0.0038 0.0251 0.054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0855 0.9062 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0147 0.1435 0.1578
Onchocerca volvulus 0.0289 0.2957 0.4693
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.013 0.0094
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0028 0.0152 0.0167
Entamoeba histolytica hypothetical protein 0.0038 0.0251 0.0592
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0038 0.0251 0.054
Plasmodium vivax unspecified product 0.0087 0.0788 0.2595
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.2004
Echinococcus multilocularis cpg binding protein 0.0037 0.0244 0.0263
Toxoplasma gondii calcium-dependent protein kinase 0.0039 0.0265 0.0737
Brugia malayi EGF-like domain containing protein 0.0053 0.042 0.0444
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.013 0.0317
Leishmania major importin beta-1 subunit, putative 0.0024 0.0104 0.0186
Loa Loa (eye worm) hypothetical protein 0.0053 0.0421 0.0465
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0053 0.042 0.0444
Brugia malayi Bromodomain containing protein 0.0092 0.0843 0.0911
Mycobacterium tuberculosis Probable lipase LipD 0.0147 0.1435 0.1391
Echinococcus granulosus calcium uptake protein 1 0.0038 0.0254 0.0274
Trichomonas vaginalis calpain, putative 0.0078 0.0685 0.1914
Toxoplasma gondii aspartyl protease 0.0028 0.0152 0.0385
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0081 0.0068
Plasmodium falciparum plasmepsin IX 0.011 0.1028 0.3414
Schistosoma mansoni hypothetical protein 0.0078 0.0685 0.0737
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0289 0.2957 0.9106
Leishmania major pyruvate kinase 0.0033 0.0201 0.0489
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0051 0.0007
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0024 0.0006
Brugia malayi cathepsin F-like cysteine proteinase 0.0073 0.0633 0.0679
Plasmodium falciparum serine repeat antigen 9 0.0073 0.0633 0.2063
Loa Loa (eye worm) hypothetical protein 0.0583 0.613 0.6764
Trypanosoma cruzi caltractin, putative 0.0038 0.0251 0.0229
Brugia malayi Animal haem peroxidase family protein 0.0583 0.613 0.6758
Brugia malayi Cathepsin L-like precursor 0.0289 0.2957 0.3249
Loa Loa (eye worm) calpain D 0.0078 0.0685 0.0756
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0633 0.1748
Giardia lamblia Cathepsin B precursor 0.0073 0.0633 0.1882
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0038 0.0254 0.0232
Schistosoma mansoni neuronal calcium sensor 0.0038 0.0251 0.0257
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0289 0.2957 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0087 0.0788 0.0851
Loa Loa (eye worm) hypothetical protein 0.0855 0.9062 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0278 0.2842 0.3102
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0401 0.0422
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.0633 0.0679
Echinococcus granulosus caspase 3 0.0072 0.062 0.0678
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0255 0.0261
Schistosoma mansoni cathepsin D (A01 family) 0.0123 0.1175 0.1278
Giardia lamblia Hypothetical protein 0.0073 0.0633 0.1882
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0251 0.0646
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0201 0.0222
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0073 0.0633 0.2063
Plasmodium vivax vivapain-2 0.0289 0.2957 1
Plasmodium falciparum serine repeat antigen 5 0.0073 0.0633 0.2063
Giardia lamblia Hypothetical protein 0.0073 0.0633 0.1882
Brugia malayi prolyl oligopeptidase family protein 0.0134 0.1286 0.1401
Echinococcus multilocularis histone acetyltransferase MYST2 0.0062 0.0514 0.0561
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0073 0.0633 0.1748
Echinococcus granulosus cathepsin l1 0.0289 0.2957 0.3259
Onchocerca volvulus 0.0038 0.0254 0.0171
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.014 0.1353 0.4027
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0078 0.0685 0.071
Echinococcus multilocularis protein jagged 1 0.0053 0.042 0.0457
Brugia malayi Pre-SET motif family protein 0.0031 0.0179 0.0178
Schistosoma mansoni hypothetical protein 0.0316 0.325 0.3574
Onchocerca volvulus 0.0053 0.042 0.0449
Chlamydia trachomatis pyruvate kinase 0.0033 0.0201 0.5
Brugia malayi Calmodulin-like protein 0.0038 0.0251 0.0257
Trypanosoma brucei calmodulin, putative 0.0038 0.0251 0.0646
Mycobacterium leprae Probable lipase LipE 0.0147 0.1435 0.1341
Brugia malayi Animal haem peroxidase family protein 0.0583 0.613 0.6758
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Echinococcus granulosus cathepsin b 0.0855 0.9062 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.013 0.0157
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0278 0.2842 0.3102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0633 0.1748
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0855 0.0944
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0289 0.2957 0.9106
Leishmania major cathepsin L-like protease 0.0289 0.2957 0.9116
Plasmodium falciparum flap endonuclease 1 0.0026 0.013 0.0348
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.008 0.0711 0.0765
Loa Loa (eye worm) animal heme peroxidase 0.0583 0.613 0.6764
Echinococcus granulosus microtubule associated protein 2 0.0682 0.7197 0.7941
Onchocerca volvulus 0.0053 0.042 0.0449
Schistosoma mansoni cathepsin D (A01 family) 0.0123 0.1175 0.1278
Trypanosoma brucei centrin, putative 0.0038 0.0251 0.0646
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0254 0.077
Schistosoma mansoni notch 0.0053 0.042 0.0444
Giardia lamblia Encystation-specific protease 0.0073 0.0633 0.1882
Schistosoma mansoni cathepsin F (C01 family) 0.0289 0.2957 0.3249
Echinococcus multilocularis protein jagged 1 0.0053 0.042 0.0457
Echinococcus multilocularis cathepsin L cysteine protease 0.0289 0.2957 0.3259
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0028 0.0152 0.0161
Toxoplasma gondii cathepsin B 0.0315 0.324 1
Onchocerca volvulus 0.0108 0.1013 0.1441
Echinococcus granulosus histone acetyltransferase MYST2 0.0062 0.0514 0.0561
Trypanosoma cruzi major cysteine proteinase, putative 0.0073 0.0633 0.0652
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0104 0.0076
Entamoeba histolytica cysteine protease, putative 0.016 0.1575 0.5195
Giardia lamblia Cathepsin B precursor 0.0073 0.0633 0.1882
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.2004
Loa Loa (eye worm) hypothetical protein 0.0583 0.613 0.6764
Trypanosoma brucei hypothetical protein, conserved 0.0147 0.1435 0.4352
Brugia malayi mbt repeat family protein 0.0054 0.0433 0.0458
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0201 0.0083
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0073 0.0633 0.0679
Trypanosoma brucei calpain-like protein, putative 0.0278 0.2842 0.8755
Giardia lamblia Cathepsin B precursor 0.0073 0.0633 0.1882
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0053 0.0418 0.0393
Giardia lamblia Cysteine protease 0.0073 0.0633 0.1882
Onchocerca volvulus 0.0031 0.0179 0.0046
Trypanosoma brucei metacaspase 0.014 0.1353 0.4094
Toxoplasma gondii aspartyl protease ASP1 0.0028 0.0152 0.0385
Echinococcus granulosus lamin dm0 0.0031 0.0178 0.019
Entamoeba histolytica cysteine protease, putative 0.016 0.1575 0.5195
Loa Loa (eye worm) hypothetical protein 0.0303 0.3108 0.3429
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0201 0.0173
Plasmodium falciparum plasmepsin VI 0.0028 0.0152 0.0422
Trypanosoma cruzi calmodulin, putative 0.0038 0.0251 0.0229
Brugia malayi EF hand family protein 0.0038 0.0254 0.026
Brugia malayi hypothetical protein 0.0025 0.0117 0.0108
Leishmania major proteasome beta 5 subunit, putative 0.008 0.0711 0.2084
Schistosoma mansoni cell polarity protein 0.0053 0.042 0.0444
Echinococcus multilocularis pyruvate kinase 0.0017 0.0028 0.0024
Brugia malayi Cathepsin L-like precursor 0.0289 0.2957 0.3249
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.004 0.0024
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0278 0.2842 0.8755
Entamoeba histolytica cysteine protease, putative 0.016 0.1575 0.5195
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0039 0.0262 0.0241
Trypanosoma brucei proteasome subunit beta type-5, putative 0.008 0.0711 0.2084
Toxoplasma gondii exonuclease III APE 0.0038 0.0255 0.0706
Trypanosoma brucei antigen, putative 0.0278 0.2842 0.8755
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0642 0.0703
Leishmania major calcineurin B subunit, putative 0.0038 0.0251 0.0646
Mycobacterium ulcerans lipase LipD 0.0147 0.1435 0.148
Trichomonas vaginalis calmodulin, putative 0.0038 0.0251 0.054
Mycobacterium tuberculosis Probable lipase LipE 0.0147 0.1435 0.1391
Entamoeba histolytica cysteine protease, putative 0.016 0.1575 0.5195
Trichomonas vaginalis conserved hypothetical protein 0.014 0.1353 0.4027
Schistosoma mansoni ran 0.0022 0.0081 0.0068
Trypanosoma cruzi centrin, putative 0.0041 0.0289 0.0271
Brugia malayi Papain family cysteine protease containing protein 0.0073 0.0633 0.0679
Brugia malayi Papain family cysteine protease containing protein 0.0073 0.0633 0.0679
Brugia malayi cathepsin B-like cysteine proteinase 0.0855 0.9062 1
Onchocerca volvulus 0.0289 0.2957 0.4693
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0255 0.5
Schistosoma mansoni hypothetical protein 0.0053 0.042 0.0444
Echinococcus multilocularis protein jagged 2 0.0053 0.042 0.0457
Giardia lamblia Pyruvate kinase 0.0033 0.0201 0.0539
Onchocerca volvulus 0.0053 0.042 0.0449
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.2004
Entamoeba histolytica grainin, putative 0.0038 0.0254 0.0602
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0051 0.0056
Loa Loa (eye worm) animal heme peroxidase 0.0583 0.613 0.6764
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0038 0.0251 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0289 0.2957 0.9106
Brugia malayi hypothetical protein 0.0028 0.0152 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0289 0.2957 0.9106
Onchocerca volvulus Putative cubilin 0.0053 0.042 0.0449
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0117 0.0302
Trypanosoma cruzi cruzipain precursor, putative 0.0289 0.2957 0.323
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0078 0.0685 0.071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0289 0.2957 0.9106
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.2004
Onchocerca volvulus 0.0073 0.0633 0.0804
Loa Loa (eye worm) hypothetical protein 0.0472 0.4936 0.5447
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0062 0.0514 0.0548
Trypanosoma brucei protein I/6 0.0038 0.0251 0.0646
Entamoeba histolytica cysteine proteinase, putative 0.016 0.1575 0.5195
Loa Loa (eye worm) hypothetical protein 0.0057 0.046 0.0507
Leishmania major calmodulin-like protein 0.0038 0.0251 0.0646
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0401 0.0437
Echinococcus multilocularis GPCR, family 2 0.0018 0.004 0.0038
Plasmodium falciparum importin beta, putative 0.003 0.0165 0.0466
Brugia malayi PHD-finger family protein 0.0032 0.019 0.019
Trypanosoma brucei calmodulin, putative 0.0038 0.0254 0.0653
Brugia malayi mbt repeat family protein 0.0054 0.0433 0.0458
Echinococcus multilocularis caspase 8 0.014 0.1353 0.1487
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.013 0.0266
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Plasmodium falciparum metacaspase-like protein 0.014 0.1353 0.4522
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0255 0.0606
Trypanosoma brucei protein kinase, putative 0.0113 0.1065 0.3191
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Plasmodium vivax vivapain-2 0.0289 0.2957 1
Plasmodium falciparum serine repeat antigen 2 0.0073 0.0633 0.2063
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0038 0.0251 0.0229
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Loa Loa (eye worm) calpain family protein 1 0.075 0.7932 0.8753
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0113 0.1065 0.3191
Entamoeba histolytica calcium-binding protein, putative 0.0038 0.0251 0.0593
Echinococcus granulosus protein jagged 2 0.0053 0.042 0.0457
Brugia malayi EGF-like domain containing protein 0.0053 0.042 0.0444
Trypanosoma cruzi major cysteine proteinase, putative 0.0073 0.0633 0.0652
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0433 0.0471
Schistosoma mansoni flap endonuclease-1 0.0024 0.0103 0.0093
Entamoeba histolytica cysteine protease, putative 0.016 0.1575 0.5195
Trypanosoma brucei prolyl oligopeptidase, putative 0.0053 0.0418 0.1169
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0052 0.0036
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0117 0.0079
Loa Loa (eye worm) hypothetical protein 0.0583 0.613 0.6764
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0134 0.1286 0.3884
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0886 0.9404 0.9401
Brugia malayi Pre-SET motif family protein 0.0211 0.2125 0.233
Schistosoma mansoni notch 0.0053 0.042 0.0444
Onchocerca volvulus Peroxidasin homolog 0.0583 0.613 1
Schistosoma mansoni calpain C (C02 family) 0.0278 0.2842 0.3122
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.014 0.1353 0.4027
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.2004
Schistosoma mansoni hypothetical protein 0.0339 0.3499 0.3848
Onchocerca volvulus Slit protein homolog 0.0053 0.042 0.0449
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0633 0.1748
Brugia malayi Cadherin domain containing protein 0.0053 0.042 0.0444
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Echinococcus multilocularis beta LACTamase domain containing family member 0.0147 0.1435 0.1578
Echinococcus multilocularis pyruvate kinase 0.0017 0.0028 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.1435 0.4288
Brugia malayi beta-lactamase family protein 0.0147 0.1435 0.1566
Trypanosoma cruzi centrin-3 0.0041 0.0289 0.0271
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0073 0.0633 0.2063
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0068 0.0054
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0401 0.0437
Giardia lamblia Proteasome subunit beta type 5 precursor 0.008 0.0711 0.2125
Echinococcus multilocularis calpain 7 (C02 family) 0.0278 0.2842 0.3131
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0178 0.0196
Brugia malayi Muscleblind-like protein 0.018 0.1791 0.196
Loa Loa (eye worm) hypothetical protein 0.0163 0.1601 0.1767
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0038 0.0251 0.0271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.2957 0.9116
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0289 0.2957 0.3263
Trypanosoma cruzi calmodulin, putative 0.0038 0.0251 0.0229
Giardia lamblia Cathepsin B precursor 0.0315 0.324 1
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.1065 0.3115
Plasmodium vivax SET domain protein, putative 0.0031 0.0179 0.0516
Onchocerca volvulus 0.0583 0.613 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0024 0.0026
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0642 0.0703
Plasmodium vivax vivapain-3 0.016 0.1575 0.5281
Entamoeba histolytica hypothetical protein 0.0024 0.0104 0.0083
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0117 0.0302
Loa Loa (eye worm) hypothetical protein 0.0063 0.0527 0.0581
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0201 0.0539
Trypanosoma brucei Metacaspase-4 0.014 0.1353 0.4094
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0255 0.0204
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0068 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0289 0.2957 0.9106
Entamoeba histolytica calpain family cysteine protease, putative 0.0078 0.0685 0.2102
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Mycobacterium leprae proteasome (beta subunit) PrcB 0.008 0.0711 0.0554
Leishmania major kinesin, putative 0.02 0.2002 0.6127
Loa Loa (eye worm) hypothetical protein 0.0073 0.0633 0.0698
Plasmodium falciparum serine repeat antigen 7 0.0073 0.0633 0.2063
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0583 0.613 0.6764
Echinococcus multilocularis pyruvate kinase 0.0026 0.0126 0.0133
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0369 0.0388
Onchocerca volvulus Cathepsin L homolog 0.0289 0.2957 0.4693
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0433 0.0458
Trypanosoma cruzi cysteine peptidase, putative 0.0289 0.2957 0.323
Echinococcus granulosus mitogen activated protein kinase 3 0.0113 0.1065 0.1169
Schistosoma mansoni zinc finger protein 0.0018 0.0045 0.0029
Trypanosoma brucei calpain-like protein, putative 0.0278 0.2842 0.8755
Echinococcus granulosus geminin 0.0543 0.5696 0.6283
Brugia malayi calcium-binding protein 0.0038 0.0251 0.0257
Entamoeba histolytica cysteine proteinase, putative 0.016 0.1575 0.5195
Giardia lamblia Cathepsin B precursor 0.0073 0.0633 0.1882
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0327 0.0312
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0019 0.0021
Onchocerca volvulus 0.0472 0.4936 0.8004
Trypanosoma brucei Calpain-like protein 2 0.0078 0.0685 0.2004
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0255 0.0218
Entamoeba histolytica cysteine proteinase, putative 0.0289 0.2957 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.2004
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0804 0.8512 0.9392
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0134 0.1286 0.1401
Entamoeba histolytica hypothetical protein 0.0038 0.0251 0.0592
Echinococcus granulosus calmodulin 0.0038 0.0251 0.0271
Brugia malayi Animal haem peroxidase family protein 0.0583 0.613 0.6758
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Plasmodium vivax calpain, putative 0.0278 0.2842 0.9606
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0073 0.0633 0.1748
Entamoeba histolytica hypothetical protein 0.0038 0.0251 0.0592
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0078 0.0685 0.071
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0255 0.0233
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0078 0.0685 0.2004
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.046 0.0488
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0051 0.0007
Schistosoma mansoni septate junction protein 0.0053 0.042 0.0444
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Plasmodium vivax aspartyl protease, putative 0.011 0.1028 0.3414
Loa Loa (eye worm) hypothetical protein 0.0053 0.042 0.0464
Echinococcus granulosus proteasome prosome macropain 0.008 0.0711 0.0778
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0327 0.0295
Loa Loa (eye worm) ctsf protein 0.0289 0.2957 0.3263
Trichomonas vaginalis conserved hypothetical protein 0.014 0.1353 0.4027
Brugia malayi CXXC zinc finger family protein 0.0033 0.0199 0.02
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0113 0.1065 0.1131
Echinococcus granulosus cathepsin l1 0.0201 0.2015 0.2218
Toxoplasma gondii EFHC1, putative 0.0038 0.0251 0.0695
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0028 0.0152 0.0385
Trichomonas vaginalis calmodulin, putative 0.0038 0.0251 0.054
Leishmania major cathepsin L-like protease 0.0289 0.2957 0.9116
Loa Loa (eye worm) hypothetical protein 0.0073 0.0633 0.0698
Brugia malayi GCC2 and GCC3 family protein 0.0053 0.042 0.0444
Plasmodium falciparum calpain 0.0078 0.0685 0.2243
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0255 0.0657
Mycobacterium tuberculosis Probable peptidase 0.0053 0.0418 0.0369
Toxoplasma gondii prolyl endopeptidase 0.0134 0.1286 0.3916
Toxoplasma gondii ABC1 family protein 0.0147 0.1435 0.4381
Echinococcus granulosus protein jagged 1 0.0053 0.042 0.0457
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.2412 0.2656
Brugia malayi Calcium binding EGF domain containing protein 0.0053 0.042 0.0444
Onchocerca volvulus 0.0163 0.1601 0.2424
Trypanosoma cruzi cysteine proteinase, putative 0.016 0.1575 0.1697
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0052 0.0007
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0073 0.0633 0.0679
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0201 0.0222
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0081 0.0179
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0078 0.0685 0.1914
Brugia malayi Cathepsin L-like cysteine proteinase 0.0201 0.2015 0.2207
Leishmania major hypothetical protein, unknown function 0.0078 0.0685 0.2004
Entamoeba histolytica grainin 2 0.0041 0.0289 0.0726
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.071
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0078 0.0685 0.071
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0073 0.0633 0.2063
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0559 0.1651
Onchocerca volvulus Dual oxidase homolog 0.0583 0.613 1
Trypanosoma brucei oligopeptidase b 0.0053 0.0418 0.1169
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0327 0.0354
Echinococcus granulosus GPCR family 2 0.0018 0.004 0.0038
Plasmodium vivax vivapain-1 0.016 0.1575 0.5281
Schistosoma mansoni cathepsin F (C01 family) 0.0289 0.2957 0.3249
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.016 0.0169
Brugia malayi calpain family protein 1 0.075 0.7932 0.8751
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0642 0.0709
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.016 0.1575 0.1721
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0201 0.0591
Trichomonas vaginalis centrin, putative 0.0038 0.0251 0.054
Onchocerca volvulus 0.0241 0.2439 0.3827
Toxoplasma gondii proteasome subunit beta type, putative 0.008 0.0711 0.2125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0855 0.0925
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0315 0.324 1
Mycobacterium ulcerans beta-lactamase 0.0147 0.1435 0.148
Schistosoma mansoni hypothetical protein 0.0053 0.042 0.0444
Trichomonas vaginalis conserved hypothetical protein 0.014 0.1353 0.4027
Echinococcus multilocularis neurogenic locus protein delta 0.0053 0.042 0.0457
Trypanosoma cruzi cysteine protease, putative 0.016 0.1575 0.1697
Loa Loa (eye worm) animal heme peroxidase 0.0583 0.613 0.6764
Brugia malayi Cathepsin L-like precursor 0.0087 0.0788 0.0851
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0289 0.2957 1
Plasmodium vivax plasmepsin IV, putative 0.0028 0.0152 0.0422
Trichomonas vaginalis calcineurin B subunit, putative 0.0038 0.0251 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0073 0.0633 0.1748
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0855 0.9062 1
Trichomonas vaginalis calmodulin, putative 0.0038 0.0251 0.054
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.014 0.1353 0.4027
Brugia malayi isocitrate dehydrogenase 0.0019 0.0052 0.0036
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0052 0.008
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0152 0.0147
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0007
Echinococcus multilocularis muscleblind protein 0.018 0.1791 0.1971
Brugia malayi Cytochrome P450 family protein 0.0019 0.0051 0.0036
Echinococcus granulosus mitogen activated protein kinase 0.0113 0.1065 0.1169
Plasmodium vivax aspartyl protease, putative 0.0028 0.0152 0.0422
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0633 0.1748
Brugia malayi calpain 5 0.02 0.2002 0.2193
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.071
Plasmodium falciparum serine repeat antigen 8 0.0073 0.0633 0.2063
Brugia malayi Cadherin domain containing protein 0.0053 0.042 0.0444
Schistosoma mansoni pyruvate kinase 0.0017 0.0028 0.0011
Onchocerca volvulus 0.0053 0.042 0.0449
Loa Loa (eye worm) hypothetical protein 0.0201 0.2015 0.2223
Leishmania major oligopeptidase b 0.0053 0.0418 0.1169
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0113 0.1065 0.3191
Echinococcus multilocularis snurportin 1 0.0316 0.325 0.3583
Giardia lamblia Cathepsin L precursor 0.0073 0.0633 0.1882
Echinococcus granulosus importin subunit beta 1 0.003 0.0165 0.0175
Schistosoma mansoni hypothetical protein 0.0053 0.042 0.0444
Plasmodium falciparum serine repeat antigen 6 0.0073 0.0633 0.2063
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.0152 0.0147
Schistosoma mansoni reticulocalbin 0.0038 0.0254 0.026
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0278 0.2842 0.3102
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0073 0.0633 0.2063
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0038 0.0251 0.0646
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0073 0.0633 0.1919
Entamoeba histolytica hypothetical protein, conserved 0.0038 0.0254 0.0602
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0289 0.2957 0.9106
Onchocerca volvulus Peroxidase homolog 0.0583 0.613 1
Echinococcus multilocularis caspase 2 0.0303 0.3108 0.3425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0289 0.2957 0.9106
Echinococcus multilocularis calpain A 0.0788 0.834 0.9203
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0053 0.0418 0.1169
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0165 0.0425
Schistosoma mansoni memapsin-2 (A01 family) 0.0431 0.4498 0.4953
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.071
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0073 0.0633 0.1748
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0201 0.0161
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0053 0.0418 0.1169
Plasmodium falciparum serine repeat antigen 3 0.0073 0.0633 0.2063
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0147 0.1435 0.1584
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0078 0.0685 0.2004
Loa Loa (eye worm) hypothetical protein 0.0085 0.0767 0.0846
Plasmodium falciparum cysteine proteinase falcipain 3 0.0289 0.2957 1
Leishmania major cysteine peptidase A (CPA) 0.0289 0.2957 0.9116
Loa Loa (eye worm) hypothetical protein 0.0062 0.0514 0.0568
Trichomonas vaginalis calcium binding protein, putative 0.0041 0.0289 0.0661
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0201 0.0489
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0222 0.2243 0.247
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0117 0.0275
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.014 0.1353 0.4124
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0289 0.2957 0.3263
Entamoeba histolytica cysteine proteinase, putative 0.016 0.1575 0.5195
Entamoeba histolytica cysteine proteinase, putative 0.0289 0.2957 1
Plasmodium falciparum plasmepsin III 0.0028 0.0152 0.0422
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.014 0.1353 0.4027
Loa Loa (eye worm) calpain 5 0.02 0.2002 0.2209
Trichomonas vaginalis centrin, putative 0.0038 0.0251 0.054
Mycobacterium tuberculosis Conserved protein 0.0147 0.1435 0.1391
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.1435 0.4288
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0314 0.034
Loa Loa (eye worm) hypothetical protein 0.0147 0.1435 0.1584
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0147 0.1435 0.1391
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.016 0.0156
Brugia malayi EF hand family protein 0.0038 0.0251 0.0257
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.2125 0.2345
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0314 0.034
Loa Loa (eye worm) hypothetical protein 0.0073 0.0633 0.0698
Trypanosoma brucei metacaspase 5, putative 0.014 0.1353 0.4094
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.016 0.1575 0.1697
Loa Loa (eye worm) hypothetical protein 0.0038 0.0251 0.0277
Leishmania major calmodulin-like protein 0.0038 0.0251 0.0646
Trypanosoma brucei Calpain-like protein 1.2 0.0078 0.0685 0.2004
Leishmania major hypothetical protein, conserved 0.0025 0.0117 0.0224
Echinococcus multilocularis hypothetical protein 0.0278 0.2842 0.3131
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0053 0.0418 0.0414
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.2957 0.9116
Giardia lamblia High cysteine protein 0.0053 0.042 0.122
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0044
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.014 0.1353 0.4124
Toxoplasma gondii hypothetical protein 0.0078 0.0685 0.2046
Echinococcus multilocularis Transglutaminase 0.0108 0.1013 0.1112
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0078 0.0685 0.2004
Schistosoma mansoni calmodulin related calcium binding protein 0.0038 0.0251 0.0257
Entamoeba histolytica cysteine protease, putative 0.016 0.1575 0.5195
Schistosoma mansoni hypothetical protein 0.0053 0.042 0.0444
Trypanosoma brucei calpain, putative 0.0078 0.0685 0.2004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0289 0.2957 0.9106
Brugia malayi Cathepsin L-like precursor 0.0289 0.2957 0.3249
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.008 0.0711 0.0663
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0201 0.2015 0.2185
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0081 0.0039
Mycobacterium tuberculosis Hypothetical protein 0.0108 0.1013 0.0966
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0019 0.0014
Echinococcus multilocularis neurogenic locus notch protein 0.0053 0.042 0.0457

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) 0.1995 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.9093 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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