TDR Targets

Basic information

Technical information

TDR Targets ID: 1392423
Name: 2-[(2-fluorophenyl)methylsulfanyl]-4,6-dimeth ylpyridine-3-carbonitrile
MW: 272.341 | Formula: C15H13FN2S
H donors: 0 H acceptors: 2 LogP: 3.77 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1c(C)cc(nc1SCc1ccccc1F)C
InChi: 1S/C15H13FN2S/c1-10-7-11(2)18-15(13(10)8-17)19-9-12-5-3-4-6-14(12)16/h3-7H,9H2,1-2H3
InChiKey: MJDDDMKIORFGEX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[(2-fluorophenyl)methylsulfanyl]-4,6-dimethyl-pyridine-3-carbonitrile
2-[(2-fluorophenyl)methylthio]-4,6-dimethyl-3-pyridinecarbonitrile
2-[(2-fluorobenzyl)thio]-4,6-dimethyl-nicotinonitrile
A0037/0001552
2-(2-Fluoro-benzylsulfanyl)-4,6-dimethyl-nicotinonitrile
BAS 07416937
MLS000709583
SMR000288050
ZINC00031801

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	calmodulin, putative	0.0546	0.0434	0.1171
Echinococcus multilocularis	neurocalcin	0.0546	0.0434	0.0434
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.3562	0.2982	0.9002
Schistosoma mansoni	neuronal calcium sensor	0.0546	0.0434	0.0434
Echinococcus multilocularis	cathepsin b	1.187	1	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.0782
Plasmodium vivax	serine-repeat antigen (SERA)	0.0356	0.0274	0.0743
Toxoplasma gondii	centrin, putative	0.0546	0.0434	0.1171
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0546	0.0434	0.183
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0546	0.0434	0.183
Loa Loa (eye worm)	cathepsin B	0.3917	0.3282	0.3282
Trypanosoma brucei	Calpain-like protein 1.2	0.1019	0.0834	0.1861
Giardia lamblia	Cathepsin L precursor	0.0356	0.0274	0.0674
Giardia lamblia	Cathepsin B precursor	0.3917	0.3282	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Echinococcus granulosus	calpain	0.3562	0.2982	0.2981
Trichomonas vaginalis	calmodulin, putative	0.0645	0.0518	0.143
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.1861
Echinococcus granulosus	calumenin	0.0551	0.0439	0.0438
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0356	0.0274	0.0743
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.3562	0.2982	0.2942
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0356	0.0274	0.2797
Trypanosoma cruzi	cysteine peptidase, putative	0.0356	0.0274	0.0219
Echinococcus granulosus	cathepsin L	0.0356	0.0274	0.0273
Giardia lamblia	Hypothetical protein	0.0356	0.0274	0.0674
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.0782
Echinococcus multilocularis	calpain A	1.0116	0.8518	0.8518
Trichomonas vaginalis	calcium binding protein, putative	0.0546	0.0434	0.1171
Leishmania major	calpain family cysteine protease-like protein	0.1019	0.0834	0.1861
Trichomonas vaginalis	calmodulin, putative	0.0551	0.0439	0.1185
Schistosoma mansoni	cathepsin F (C01 family)	0.0356	0.0274	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0274	0.0274
Plasmodium falciparum	serine repeat antigen 2	0.0356	0.0274	0.2797
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1019	0.0834	0.0782
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.1019	0.0834	0.0782
Schistosoma mansoni	reticulocalbin	0.0546	0.0434	0.0434
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0356	0.0274	0.0273
Brugia malayi	EF hand family protein	0.0546	0.0434	0.0434
Toxoplasma gondii	cathepsin CPL	0.0356	0.0274	0.0674
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0356	0.0274	0.0674
Trichomonas vaginalis	conserved hypothetical protein	0.1019	0.0834	0.2409
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.1861
Plasmodium falciparum	serine repeat antigen 1	0.0356	0.0274	0.2797
Echinococcus multilocularis	cathepsin L	0.0356	0.0274	0.0273
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.3917	0.3282	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Trypanosoma cruzi	cysteine protease, putative	0.0356	0.0274	0.0219
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0356	0.0274	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0056	0.0056
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.1019	0.0834	0.2409
Brugia malayi	Cathepsin L-like precursor	0.0356	0.0274	0.0273
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Schistosoma mansoni	calpain (C02 family)	0.3562	0.2982	0.2981
Trypanosoma brucei	cysteine peptidase C (CPC)	0.3917	0.3282	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0001	0.0001
Trichomonas vaginalis	calcium binding proteins, putative	0.0546	0.0434	0.1171
Plasmodium falciparum	serine repeat antigen 9	0.0356	0.0274	0.2797
Echinococcus multilocularis	cathepsin b	1.187	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0356	0.0274	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0056	0.0056
Trypanosoma brucei	centrin-3	0.0645	0.0518	0.0811
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0356	0.0274	0.1053
Trichomonas vaginalis	conserved hypothetical protein	0.0546	0.0434	0.1171
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Trypanosoma brucei	cysteine peptidase, putative	0.1019	0.0834	0.1861
Trypanosoma cruzi	mitochondrial calcium uptake 1, putative	0.0546	0.0434	0.038
Entamoeba histolytica	cysteine proteinase 2	0.0356	0.0274	0.1053
Trichomonas vaginalis	conserved hypothetical protein	0.0356	0.0274	0.0674
Echinococcus multilocularis	centrin 2	0.0546	0.0434	0.0434
Trichomonas vaginalis	calcium binding protein, putative	0.0546	0.0434	0.1171
Trypanosoma brucei	calmodulin, putative	0.0551	0.0439	0.0548
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.1861
Entamoeba histolytica	calcium binding family protein	0.0546	0.0434	0.183
Brugia malayi	Papain family cysteine protease containing protein	0.0356	0.0274	0.0273
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0356	0.0274	0.0674
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Brugia malayi	cathepsin F-like cysteine proteinase	0.0356	0.0274	0.0273
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Echinococcus granulosus	neuronal calcium sensor	0.0546	0.0434	0.0434
Echinococcus multilocularis	EF HAND 1, calcium binding site	0.0546	0.0434	0.0434
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0356	0.0274	0.0219
Trypanosoma brucei	kinesin, putative	0.2543	0.2121	0.6141
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0356	0.0274	0.0273
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	1.187	1	1
Leishmania major	programmed cell death 6 protein-like protein	0.0546	0.0434	0.0533
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.1861
Echinococcus granulosus	calbindin 32	0.0551	0.0439	0.0438
Echinococcus multilocularis	EF hand domain containing family member A2	0.0551	0.0439	0.0438
Schistosoma mansoni	calmodulin-related	0.0099	0.0056	0.0056
Echinococcus multilocularis	calmodulin	0.0546	0.0434	0.0434
Trichomonas vaginalis	calmodulin, putative	0.0546	0.0434	0.1171
Loa Loa (eye worm)	programmed cell death protein 6	0.0551	0.0439	0.0439
Echinococcus multilocularis	programmed cell death protein 6	0.0104	0.0061	0.006
Trypanosoma cruzi	kinesin, putative	0.2543	0.2121	0.2076
Onchocerca volvulus		0.0356	0.0274	0.0542
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0356	0.0274	0.0674
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0356	0.0274	0.0274
Echinococcus multilocularis	calmodulin	0.0546	0.0434	0.0434
Trypanosoma brucei	hypothetical protein, conserved	0.0546	0.0434	0.0533
Trypanosoma cruzi	major cysteine proteinase, putative	0.0356	0.0274	0.0219
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0356	0.0274	0.0273
Brugia malayi	calpain 5	0.1019	0.0834	0.0833
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0356	0.0274	0.0674
Brugia malayi	calpain family protein 1	0.9564	0.8052	0.8052
Entamoeba histolytica	calmodulin, putative	0.0546	0.0434	0.183
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0356	0.0274	0.2797
Leishmania major	centrin, putative	0.0546	0.0434	0.0533
Giardia lamblia	Cathepsin L precursor	0.0356	0.0274	0.0674
Trypanosoma cruzi	centrin, putative	0.0645	0.0518	0.0464
Brugia malayi	Papain family cysteine protease containing protein	0.0356	0.0274	0.0273
Brugia malayi	Papain family cysteine protease containing protein	0.0356	0.0274	0.0273
Echinococcus multilocularis	calpain 5	0.3562	0.2982	0.2981
Giardia lamblia	Cathepsin B precursor	0.3917	0.3282	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Onchocerca volvulus	Mitochondrial Rho GTPase homolog	0.0099	0.0056	0.0111
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0274	0.0274
Echinococcus granulosus	calpain A	1.0116	0.8518	0.8518
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0356	0.0274	0.2797
Echinococcus granulosus	cathepsin b	1.187	1	1
Schistosoma mansoni	neuronal calcium sensor	0.0546	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0274	0.0274
Giardia lamblia	Cathepsin B precursor	0.0356	0.0274	0.0674
Leishmania major	hypothetical protein, conserved	0.0546	0.0434	0.0533
Giardia lamblia	Cysteine protease	0.0356	0.0274	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0274	0.0274
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0546	0.0434	0.038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3917	0.3282	0.3282
Trichomonas vaginalis	calmodulin, putative	0.0546	0.0434	0.1171
Trypanosoma cruzi	cysteine peptidase, putative	0.0356	0.0274	0.0219
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	1.187	1	1
Brugia malayi	cathepsin L precursor	0.0356	0.0274	0.0273
Loa Loa (eye worm)	EF hand family protein	0.0546	0.0434	0.0434
Trypanosoma brucei	I/6 autoantigen	0.0546	0.0434	0.0533
Toxoplasma gondii	calcium-dependent protein kinase	0.0551	0.0439	0.1185
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Brugia malayi	Papain family cysteine protease containing protein	0.0356	0.0274	0.0273
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	1.187	1	1
Brugia malayi	Cathepsin L-like precursor	0.0356	0.0274	0.0273
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0274	0.0274
Giardia lamblia	Cathepsin L-like protease	0.0356	0.0274	0.0674
Trypanosoma brucei	hypothetical protein	0.1019	0.0834	0.1861
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0356	0.0274	0.0274
Trichomonas vaginalis	calmodulin, putative	0.0546	0.0434	0.1171
Brugia malayi	Cathepsin L-like precursor	0.0356	0.0274	0.0273
Entamoeba histolytica	cysteine proteinase, putative	0.0356	0.0274	0.1053
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0356	0.0274	0.0674
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.1861
Brugia malayi	RasGEF domain containing protein	0.0099	0.0056	0.0056
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0546	0.0434	0.038
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1019	0.0834	0.0782
Loa Loa (eye worm)	hypothetical protein	0.0546	0.0434	0.0434
Giardia lamblia	Hypothetical protein	0.0356	0.0274	0.0674
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.3562	0.2982	0.9002
Giardia lamblia	Cathepsin B precursor	0.0356	0.0274	0.0674
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0356	0.0274	0.0743
Brugia malayi	Cathepsin L-like precursor	0.0356	0.0274	0.0273
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0356	0.0274	0.0273
Onchocerca volvulus	Myosin regulatory light chain 2 homolog	0.0099	0.0056	0.0111
Brugia malayi	cathepsin L-like cysteine proteinase	0.0356	0.0274	0.0273
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1019	0.0834	0.0782
Entamoeba histolytica	cysteine proteinase, putative	0.0356	0.0274	0.1053
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0356	0.0274	0.0273
Entamoeba histolytica	grainin, putative	0.0551	0.0439	0.1851
Trypanosoma brucei	centrin, putative	0.0546	0.0434	0.0533
Echinococcus multilocularis	cysteine protease	0.0356	0.0274	0.0273
Trypanosoma brucei	mitochondrial calcium uptake 1	0.0546	0.0434	0.0533
Echinococcus granulosus	calcium uptake protein 1	0.0551	0.0439	0.0438
Entamoeba histolytica	calpain family cysteine protease, putative	0.1019	0.0834	0.3764
Echinococcus multilocularis	calumenin	0.0551	0.0439	0.0438
Trypanosoma brucei	Calpain-like protein 1.1	0.1019	0.0834	0.1861
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0356	0.0274	0.2797
Loa Loa (eye worm)	hypothetical protein	0.0546	0.0434	0.0434
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.1861
Trichomonas vaginalis	Crustacean calcium-binding protein, putative	0.0546	0.0434	0.1171
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.3562	0.2982	0.9002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Echinococcus granulosus	cathepsin L cysteine protease	0.0356	0.0274	0.0273
Echinococcus granulosus	calpain 5	0.3562	0.2982	0.2981
Echinococcus granulosus	cathepsin l1	0.0356	0.0274	0.0273
Onchocerca volvulus		0.0356	0.0274	0.0542
Schistosoma mansoni	myosin regulatory light chain	0.0099	0.0056	0.0056
Echinococcus granulosus	cysteine protease	0.0356	0.0274	0.0273
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0356	0.0274	0.0273
Trypanosoma brucei	cytoskeleton-associated protein CAP5.5, putative	0.1019	0.0834	0.1861
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0356	0.0274	0.0274
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0356	0.0274	0.0674
Plasmodium falciparum	centrin-1	0.0546	0.0434	0.4862
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.1019	0.0834	0.0782
Echinococcus multilocularis	calbindin 32	0.0551	0.0439	0.0438
Schistosoma mansoni	calpain C (C02 family)	0.3562	0.2982	0.2981
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.1019	0.0834	0.1861
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0356	0.0274	0.0674
Trypanosoma brucei	CAMK/CAMKL family protein kinase, putative	0.0546	0.0434	0.0533
Trypanosoma brucei	Calpain-like protein 2	0.1019	0.0834	0.1861
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.3562	0.2982	0.2942
Loa Loa (eye worm)	fibroinase	0.0356	0.0274	0.0274
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.1019	0.0834	0.2409
Leishmania major	calcineurin B subunit, putative	0.0546	0.0434	0.0533
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.0782
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.0782
Toxoplasma gondii	cathepsin CPC2	0.0356	0.0274	0.0674
Trichomonas vaginalis	calpain, putative	0.1019	0.0834	0.2409
Toxoplasma gondii	cathepsin B	0.3917	0.3282	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0356	0.0274	0.2797
Trypanosoma brucei	calpain-like protein, putative	0.3562	0.2982	0.9002
Giardia lamblia	Cathepsin B precursor	0.0356	0.0274	0.0674
Toxoplasma gondii	cathepsin CPC1	0.0356	0.0274	0.0674
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0546	0.0434	0.038
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.1861
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.1861
Echinococcus multilocularis	calpain 7 (C02 family)	0.3562	0.2982	0.2981
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.3917	0.3282	0.3244
Schistosoma mansoni	myosin regulatory light chain	0.0099	0.0056	0.0056
Trypanosoma cruzi	cruzipain precursor, putative	0.0356	0.0274	0.0219
Plasmodium falciparum	serine repeat antigen 8	0.0356	0.0274	0.2797
Loa Loa (eye worm)	hypothetical protein	0.6003	0.5044	0.5044
Toxoplasma gondii	EF hand domain-containing protein	0.0546	0.0434	0.1171
Leishmania major	calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.1861
Echinococcus multilocularis	calpain	0.3562	0.2982	0.2981
Echinococcus granulosus	family C2 unassigned peptidase C02 family	1.011	0.8514	0.8514
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0356	0.0274	0.0743
Trypanosoma cruzi	centrin-3	0.0645	0.0518	0.0464
Entamoeba histolytica	cysteine proteinase 1, putative	0.0356	0.0274	0.1053
Schistosoma mansoni	cathepsin S (C01 family)	0.0356	0.0274	0.0273
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.1019	0.0834	0.2409
Trichomonas vaginalis	conserved hypothetical protein	0.0546	0.0434	0.1171
Plasmodium vivax	vivapain-2	0.0356	0.0274	0.0743
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0356	0.0274	0.1053
Schistosoma mansoni	reticulocalbin	0.0551	0.0439	0.0438
Brugia malayi	calpain 5	0.2543	0.2121	0.2121
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Loa Loa (eye worm)	ctsf protein	0.0356	0.0274	0.0274
Brugia malayi	Papain family cysteine protease containing protein	0.0356	0.0274	0.0273
Trypanosoma brucei	Present in the outer mitochondrial membrane proteome 33	0.0546	0.0434	0.0533
Echinococcus multilocularis	cysteine protease	0.0356	0.0274	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0274	0.0274
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1019	0.0834	0.0782
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.9564	0.8052	0.8052
Brugia malayi	calpain family protein 1	0.9564	0.8052	0.8052
Trypanosoma brucei	centrin, putative	0.0546	0.0434	0.0533
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.1019	0.0834	0.2409
Toxoplasma gondii	EFHC1, putative	0.0546	0.0434	0.1171
Toxoplasma gondii	calmodulin CAM1	0.0551	0.0439	0.1185
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0356	0.0274	0.0274
Entamoeba histolytica	cysteine proteinase, putative	0.0356	0.0274	0.1053
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.1861
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0356	0.0274	0.0674
Entamoeba histolytica	hypothetical protein	0.0356	0.0274	0.1053
Trypanosoma brucei	antigen, putative	0.3562	0.2982	0.9002
Schistosoma mansoni	mitochondrial solute carrier	0.0546	0.0434	0.0434
Echinococcus granulosus	EF hand domain containing family member A2	0.0551	0.0439	0.0438
Brugia malayi	EF hand family protein	0.0551	0.0439	0.0438
Trypanosoma brucei	calpain-like protein, putative	0.3562	0.2982	0.9002
Plasmodium falciparum	serine repeat antigen 7	0.0356	0.0274	0.2797
Giardia lamblia	Cathepsin L precursor	0.0356	0.0274	0.0674
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.1019	0.0834	0.2409
Loa Loa (eye worm)	hypothetical protein	0.1019	0.0834	0.0834
Brugia malayi	calpain 7	0.3562	0.2982	0.2981
Leishmania major	centrin, putative	0.0546	0.0434	0.0533
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0356	0.0274	0.0674
Schistosoma mansoni	centrin-related	0.0546	0.0434	0.0434
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0356	0.0274	0.0674
Entamoeba histolytica	cysteine proteinase, putative	0.0356	0.0274	0.1053
Schistosoma mansoni	cathepsin F (C01 family)	0.0356	0.0274	0.0273
Plasmodium vivax	centrin-1, putative	0.0546	0.0434	0.1292
Trypanosoma brucei	glucosamine 6-phosphate n-acetyltransferase	0.1019	0.0834	0.1861
Echinococcus multilocularis	Myosin regulatory light chain	0.0099	0.0056	0.0056
Trypanosoma cruzi	conserved protein	0.1019	0.0834	0.0782
Giardia lamblia	Hypothetical protein	0.0551	0.0439	0.1185
Giardia lamblia	Cathepsin L precursor	0.0356	0.0274	0.0674
Loa Loa (eye worm)	calpain	0.3562	0.2982	0.2982
Schistosoma mansoni	hypothetical protein	0.1019	0.0834	0.0833
Entamoeba histolytica	calmodulin, putative	0.0546	0.0434	0.183
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	1.011	0.8514	0.8514
Giardia lamblia	Cysteine protease	0.0356	0.0274	0.0674
Echinococcus granulosus	cathepsin L	0.0356	0.0274	0.0273
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0356	0.0274	0.0674
Onchocerca volvulus		0.0356	0.0274	0.0542
Leishmania major	hypothetical protein, conserved	0.1019	0.0834	0.1861
Onchocerca volvulus		0.0356	0.0274	0.0542
Trypanosoma brucei	calpain, putative	0.1019	0.0834	0.1861
Entamoeba histolytica	grainin 2	0.0645	0.0518	0.2234
Trypanosoma cruzi	kinesin, putative	0.2543	0.2121	0.2076
Loa Loa (eye worm)	calpain D	0.1019	0.0834	0.0834
Loa Loa (eye worm)	calpain family protein 1	0.9564	0.8052	0.8052
Schistosoma mansoni	cathepsin F (C01 family)	0.0356	0.0274	0.0273
Brugia malayi	Papain family cysteine protease containing protein	0.0356	0.0274	0.0273
Echinococcus multilocularis	calcyphosin protein	0.0099	0.0056	0.0056
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Onchocerca volvulus		0.0546	0.0434	0.086
Plasmodium falciparum	serine repeat antigen 6	0.0356	0.0274	0.2797
Trypanosoma brucei	calmodulin, putative	0.0546	0.0434	0.0533
Echinococcus multilocularis	hypothetical protein	0.3562	0.2982	0.2981
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0356	0.0274	0.0273
Trypanosoma cruzi	cysteine proteinase, putative	0.0356	0.0274	0.0219
Loa Loa (eye worm)	hypothetical protein	1.187	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0356	0.0274	0.0273
Toxoplasma gondii	hypothetical protein	0.1019	0.0834	0.2409
Trichomonas vaginalis	calmodulin, putative	0.0546	0.0434	0.1171
Schistosoma mansoni	myosin light chain	0.0099	0.0056	0.0056
Echinococcus multilocularis	neuronal calcium sensor	0.0546	0.0434	0.0434
Echinococcus granulosus	Myosin regulatory light chain	0.0099	0.0056	0.0056
Leishmania major	calpain protease-like protein	0.1019	0.0834	0.1861
Plasmodium vivax	unspecified product	0.0356	0.0274	0.0743
Schistosoma mansoni	calpain-7 (C02 family)	0.3562	0.2982	0.2981
Giardia lamblia	Cathepsin L-like protease	0.0356	0.0274	0.0674
Leishmania major	calmodulin-like protein	0.0546	0.0434	0.0533
Brugia malayi	cathepsin L-like precursor	0.0356	0.0274	0.0273
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Plasmodium vivax	hypothetical protein, conserved	0.0551	0.0439	0.1307
Trypanosoma brucei	protein I/6	0.0546	0.0434	0.0533
Trichomonas vaginalis	calpain, putative	0.1019	0.0834	0.2409
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.0782
Trypanosoma cruzi	I/6 autoantigen, putative	0.0546	0.0434	0.038
Echinococcus multilocularis	cathepsin L	0.0356	0.0274	0.0273
Echinococcus multilocularis	programmed cell death protein	0.0645	0.0518	0.0517
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0356	0.0274	0.0674
Leishmania major	hypothetical protein, unknown function	0.1019	0.0834	0.1861
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0356	0.0274	0.0674
Trypanosoma cruzi	caltractin, putative	0.0546	0.0434	0.038
Trypanosoma cruzi	cysteine peptidase, putative	0.0356	0.0274	0.0219
Trichomonas vaginalis	calcineurin B subunit, putative	0.0546	0.0434	0.1171
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.1861
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0001	0.0001
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0356	0.0274	0.0743
Brugia malayi	Cathepsin L-like precursor	0.0356	0.0274	0.0273
Plasmodium vivax	vivapain-1	0.0356	0.0274	0.0743
Giardia lamblia	Cathepsin B precursor	0.0356	0.0274	0.0674
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0356	0.0274	0.0273
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.1861
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0356	0.0274	0.0743
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0356	0.0274	0.0273
Giardia lamblia	Cysteine protease	0.0356	0.0274	0.0674
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0356	0.0274	0.0273
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0356	0.0274	0.0273
Schistosoma mansoni	neuronal calcium sensor	0.0546	0.0434	0.0434
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0356	0.0274	0.0219
Brugia malayi	programmed cell death protein 6	0.0546	0.0434	0.0434
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.3562	0.2982	0.2942
Plasmodium vivax	serine-repeat antigen (SERA)	0.0356	0.0274	0.0743
Leishmania major	hypothetical protein, conserved	0.0551	0.0439	0.0548
Leishmania major	phospholipase c-like protein	0.0546	0.0434	0.0533
Onchocerca volvulus	Cathepsin F homolog	0.0356	0.0274	0.0542
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0356	0.0274	0.0674
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0356	0.0274	0.0274
Toxoplasma gondii	centrin	0.0546	0.0434	0.1171
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.0782
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.3562	0.2982	0.9002
Brugia malayi	Myosin regulatory light chain 1	0.0099	0.0056	0.0056
Loa Loa (eye worm)	calmodulin-like protein	0.0546	0.0434	0.0434
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0356	0.0274	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0274	0.0274
Brugia malayi	Cathepsin L-like precursor	0.0356	0.0274	0.0273
Schistosoma mansoni	cathepsin B (C01 family)	0.0356	0.0274	0.0273
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0356	0.0274	0.0743
Entamoeba histolytica	hypothetical protein, conserved	0.0551	0.0439	0.1851
Plasmodium falciparum	serine repeat antigen 3	0.0356	0.0274	0.2797
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0356	0.0274	0.0674
Toxoplasma gondii	troponin c, isotype gamma, putative	0.0546	0.0434	0.1171
Plasmodium vivax	unspecified product	0.0356	0.0274	0.0743
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Plasmodium vivax	vivapain-3	0.0356	0.0274	0.0743
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0551	0.0439	0.0384
Leishmania major	protein kinase, putative	0.0546	0.0434	0.0533
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.1019	0.0834	0.2409
Echinococcus multilocularis	sarcoplasmic calcium binding protein	0.0546	0.0434	0.0434
Trichomonas vaginalis	calmodulin, putative	0.0546	0.0434	0.1171
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0356	0.0274	0.0273
Trypanosoma brucei	Calpain-like protein CALP1.3	0.1019	0.0834	0.1861
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0274	0.0274
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.1861
Giardia lamblia	Encystation-specific protease	0.0356	0.0274	0.0674
Entamoeba histolytica	cysteine proteinase, putative	0.0356	0.0274	0.1053
Trypanosoma brucei	calpain, putative	0.1019	0.0834	0.1861
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0356	0.0274	0.0674
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	1.011	0.8514	0.8514
Plasmodium vivax	vivapain-2	0.0356	0.0274	0.0743
Onchocerca volvulus	Cathepsin L homolog	0.0356	0.0274	0.0542
Entamoeba histolytica	protein kinase, putative	0.2543	0.2121	1
Brugia malayi	Neuronal calcium sensor family protein 1	0.0099	0.0056	0.0056
Entamoeba histolytica	calcium-binding protein, putative	0.0546	0.0434	0.183
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0356	0.0274	0.0743
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.3917	0.3282	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0356	0.0274	0.0674
Trichomonas vaginalis	DNA-dependent protein kinase catalytic subunit-interacting protein, putative	0.0546	0.0434	0.1171
Trichomonas vaginalis	centrin, putative	0.0546	0.0434	0.1171
Trypanosoma cruzi	cysteine peptidase, putative	0.0356	0.0274	0.0219
Echinococcus granulosus	programmed cell death protein 6	0.0104	0.0061	0.006
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0546	0.0434	0.1292
Loa Loa (eye worm)	hypothetical protein	0.8546	0.7192	0.7192
Echinococcus granulosus	EF hand domain containing family member A2	0.0546	0.0434	0.0434
Giardia lamblia	Cathepsin L precursor	0.0356	0.0274	0.0674
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.3562	0.2982	0.2942
Onchocerca volvulus		0.6003	0.5044	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.0782
Schistosoma mansoni	calmodulin	0.0546	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0274	0.0274
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0001	0.0001
Giardia lamblia	Cysteine protease	0.0356	0.0274	0.0674
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.3562	0.2982	0.2942
Leishmania major	calmodulin, putative	0.0546	0.0434	0.0533
Echinococcus granulosus	cathepsin b	1.187	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0356	0.0274	0.2797
Schistosoma mansoni	calpain-2 (C02 family)	0.1019	0.0834	0.0833
Trichomonas vaginalis	conserved hypothetical protein	0.0356	0.0274	0.0674
Loa Loa (eye worm)	myosin regulatory light chain 1	0.0099	0.0056	0.0056
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.3562	0.2982	0.2942
Brugia malayi	calcium-binding protein	0.0546	0.0434	0.0434
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Toxoplasma gondii	calpain family cysteine protease domain-containing protein	0.1019	0.0834	0.2409
Onchocerca volvulus		0.0356	0.0274	0.0542
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0356	0.0274	0.0273
Leishmania major	i/6 autoantigen-like protein	0.0546	0.0434	0.0533
Schistosoma mansoni	Sarcoplasmic calcium-binding protein (SCP).	0.0546	0.0434	0.0434
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.3562	0.2982	0.9002
Leishmania major	centrin, putative,caltractin, putative	0.0546	0.0434	0.0533
Trypanosoma cruzi	calmodulin, putative	0.0546	0.0434	0.038
Trypanosoma cruzi	programmed cell death 6 protein-like, putative	0.0546	0.0434	0.038
Echinococcus granulosus	sarcoplasmic calcium binding protein	0.0546	0.0434	0.0434
Echinococcus granulosus	calpain A	0.3562	0.2982	0.2981
Echinococcus multilocularis	Calcium binding protein	0.0099	0.0056	0.0056
Echinococcus granulosus	calcyphosin protein	0.0099	0.0056	0.0056
Trichomonas vaginalis	calmodulin-2, putative	0.0546	0.0434	0.1171
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Echinococcus multilocularis	EF hand domain containing family member A2	0.0546	0.0434	0.0434
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0356	0.0274	0.0273
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Trichomonas vaginalis	calcium binding protein, putative	0.0546	0.0434	0.1171
Entamoeba histolytica	cysteine proteinase, putative	0.0356	0.0274	0.1053
Schistosoma mansoni	cathepsin C	0.0356	0.0274	0.0273
Brugia malayi	Probable myosin regulatory light chain	0.0104	0.0061	0.006
Trichomonas vaginalis	calpain, putative	0.1019	0.0834	0.2409
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Trichomonas vaginalis	myosin light chain 1, putative	0.0546	0.0434	0.1171
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0356	0.0274	0.0674
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Echinococcus granulosus	centrin 2	0.0546	0.0434	0.0434
Trypanosoma cruzi	calmodulin, putative	0.0546	0.0434	0.038
Trypanosoma cruzi	I/6 autoantigen, putative	0.0546	0.0434	0.038
Plasmodium falciparum	calpain	0.1019	0.0834	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0356	0.0274	0.0674
Loa Loa (eye worm)	cysteine protease	0.0356	0.0274	0.0274
Loa Loa (eye worm)	calpain 5	0.2543	0.2121	0.2121
Echinococcus granulosus	cathepsin l1	0.0356	0.0274	0.0273
Loa Loa (eye worm)	hypothetical protein	0.7022	0.5904	0.5904
Trypanosoma brucei	calpain-like protein, putative	0.3562	0.2982	0.9002
Loa Loa (eye worm)	hypothetical protein	0.0356	0.0274	0.0274
Loa Loa (eye worm)	calpain family protein 1	0.7022	0.5904	0.5904
Onchocerca volvulus		0.0551	0.0439	0.0869
Trypanosoma cruzi	cysteine proteinase, putative	0.0356	0.0274	0.0219
Leishmania major	calmodulin, putative	0.0546	0.0434	0.0533
Brugia malayi	Calmodulin-like protein	0.0546	0.0434	0.0434
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	1.187	1	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0356	0.0274	0.0743
Echinococcus granulosus	calpain 7 C02 family	0.3562	0.2982	0.2981
Trichomonas vaginalis	centrin, putative	0.0546	0.0434	0.1171
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0356	0.0274	0.0674
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.3562	0.2982	0.2942
Echinococcus granulosus	EF HAND 1 calcium binding site	0.0546	0.0434	0.0434
Leishmania major	calmodulin-like protein	0.0546	0.0434	0.0533
Plasmodium vivax	calpain, putative	0.3562	0.2982	1
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.1861
Echinococcus granulosus	calmodulin	0.0546	0.0434	0.0434
Onchocerca volvulus		0.0356	0.0274	0.0542
Plasmodium falciparum	serine repeat antigen 5	0.0356	0.0274	0.2797
Entamoeba histolytica	calpain large subunit domain III containing protein	0.2543	0.2121	1
Trypanosoma cruzi	centrin, putative	0.0645	0.0518	0.0464
Schistosoma mansoni	hypothetical protein	0.0546	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.9564	0.8052	0.8052
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.1019	0.0834	0.0782
Brugia malayi	Cathepsin L-like precursor	0.0356	0.0274	0.0273
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0356	0.0274	0.2797
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.3562	0.2982	0.2942
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1019	0.0834	0.0782
Trypanosoma cruzi	calmodulin, putative	0.0546	0.0434	0.038
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1019	0.0834	0.0782
Echinococcus multilocularis	calcium uptake protein 1	0.0551	0.0439	0.0438
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0356	0.0274	0.0674
Echinococcus multilocularis	programmed cell death protein	0.0645	0.0518	0.0517
Giardia lamblia	Cathepsin L precursor	0.0356	0.0274	0.0674
Giardia lamblia	Cathepsin B precursor	0.3917	0.3282	1
Schistosoma mansoni	calpain-7 (C02 family)	0.3562	0.2982	0.2981
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0356	0.0274	0.0273
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.1861
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Onchocerca volvulus		0.0356	0.0274	0.0542
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0356	0.0274	0.0674
Onchocerca volvulus		0.0099	0.0056	0.0111
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Echinococcus granulosus	neurocalcin	0.0546	0.0434	0.0434
Onchocerca volvulus		0.0356	0.0274	0.0542
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0356	0.0274	0.0273
Trichomonas vaginalis	hypothetical protein	0.1019	0.0834	0.2409
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0356	0.0274	0.0273
Schistosoma mansoni	rab	0.0546	0.0434	0.0434
Giardia lamblia	Cathepsin B precursor	0.0356	0.0274	0.0674
Trypanosoma cruzi	cysteine peptidase, putative	0.0356	0.0274	0.0219
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0356	0.0274	0.0273
Schistosoma mansoni	SmCB2 peptidase (C01 family)	1.187	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0356	0.0274	0.0542
Trichomonas vaginalis	calcium binding protein, putative	0.0645	0.0518	0.143
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Schistosoma mansoni	ef hand domain family member A2	0.0546	0.0434	0.0434
Onchocerca volvulus	Cathepsin L homolog	0.0356	0.0274	0.0542
Echinococcus multilocularis	calpain family protein 1, d	0.7022	0.5904	0.5904
Brugia malayi	calpain D	0.1019	0.0834	0.0833
Trypanosoma brucei	calpain-like protein, putative	0.3562	0.2982	0.9002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0356	0.0274	0.0674
Schistosoma mansoni	neuronal calcium sensor	0.0546	0.0434	0.0434
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Schistosoma mansoni	calcium binding atopy-related autoantigen	0.0551	0.0439	0.0438
Entamoeba histolytica	cysteine proteinase, putative	0.0356	0.0274	0.1053
Onchocerca volvulus		0.0546	0.0434	0.086
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	1.011	0.8514	0.8514
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.1861
Schistosoma mansoni	hypothetical protein	0.0546	0.0434	0.0434
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0356	0.0274	0.0743
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0356	0.0274	0.0273
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0356	0.0274	0.0674
Trichomonas vaginalis	calcineurin B subunit, putative	0.0551	0.0439	0.1185
Schistosoma mansoni	centrin	0.0546	0.0434	0.0434
Trichomonas vaginalis	calmodulin, putative	0.0546	0.0434	0.1171
Schistosoma mansoni	Mername-AA248 (C02 family)	0.3562	0.2982	0.2981
Trypanosoma cruzi	major cysteine proteinase, putative	0.0356	0.0274	0.0219
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.3562	0.2982	0.2942
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.1019	0.0834	0.0782
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0356	0.0274	0.0674
Schistosoma mansoni	calmodulin related calcium binding protein	0.0546	0.0434	0.0434
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.0782
Trypanosoma brucei	caltractin, putative	0.0645	0.0518	0.0811
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0356	0.0274	0.0743
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.1861
Brugia malayi	Cathepsin L-like precursor	0.0356	0.0274	0.0273
Entamoeba histolytica	cysteine protease, putative	0.0356	0.0274	0.1053
Echinococcus granulosus	Calcium binding protein	0.0099	0.0056	0.0056
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.1861
Loa Loa (eye worm)	myosin Light Chain family member	0.0104	0.0061	0.0061
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.3562	0.2982	0.2942
Trypanosoma brucei	Component of motile flagella 41	0.0546	0.0434	0.0533
Leishmania major	cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative	0.1019	0.0834	0.1861
Plasmodium falciparum	serine repeat antigen 4	0.0356	0.0274	0.2797
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0356	0.0274	0.0674
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0356	0.0274	0.0674
Echinococcus granulosus	programmed cell death protein	0.0645	0.0518	0.0517
Onchocerca volvulus		0.0099	0.0056	0.0111
Leishmania major	kinesin, putative	0.2543	0.2121	0.6141
Schistosoma mansoni	calmodulin	0.0546	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0056	0.0056
Onchocerca volvulus		0.0356	0.0274	0.0542
Brugia malayi	fibroinase precursor	0.0356	0.0274	0.0273

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 1.9953 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.1623 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	14.7157 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)]	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ]	ChEMBL.	No reference
Potency (binding)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	70.7946 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1531853

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1392423