Detailed information for compound 1406926

Basic information

Technical information
  • TDR Targets ID: 1406926
  • Name: phenyl N-[4-(4-ethylphenyl)-1,3-thiazol-2-yl] carbamate
  • MW: 324.397 | Formula: C18H16N2O2S
  • H donors: 1 H acceptors: 2 LogP: 4.88 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)c1csc(n1)NC(=O)Oc1ccccc1
  • InChi: 1S/C18H16N2O2S/c1-2-13-8-10-14(11-9-13)16-12-23-17(19-16)20-18(21)22-15-6-4-3-5-7-15/h3-12H,2H2,1H3,(H,19,20,21)
  • InChiKey: QRANLPFERFBRNN-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • phenyl N-[4-(4-ethylphenyl)thiazol-2-yl]carbamate
  • N-[4-(4-ethylphenyl)-2-thiazolyl]carbamic acid phenyl ester
  • N-[4-(4-ethylphenyl)thiazol-2-yl]carbamic acid phenyl ester
  • MLS000582952
  • SMR000201661
  • phenyl [4-(4-ethylphenyl)-1,3-thiazol-2-yl]carbamate
  • ZINC00151156

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0185 0.036 0.0342
Leishmania major calmodulin, putative 0.0185 0.036 0.1102
Echinococcus granulosus calpain A 0.1287 0.2885 0.2872
Trypanosoma cruzi caltractin, putative 0.0185 0.036 0.0342
Leishmania major centrin, putative 0.0185 0.036 0.1102
Echinococcus granulosus calpain 7 C02 family 0.1287 0.2885 0.2872
Trichomonas vaginalis calcium binding proteins, putative 0.0185 0.036 0.1052
Trichomonas vaginalis calmodulin, putative 0.0185 0.036 0.1052
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0135 0.0245 0.0697
Giardia lamblia Cathepsin L precursor 0.0135 0.0245 0.0697
Echinococcus multilocularis protein dispatched 1 0.0058 0.0068 0.0049
Trypanosoma brucei centrin, putative 0.0185 0.036 0.0399
Echinococcus multilocularis calmodulin 0.0185 0.036 0.0342
Giardia lamblia Cathepsin L-like protease 0.0135 0.0245 0.0697
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1451 0.3262 0.3249
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0185 0.036 0.0342
Entamoeba histolytica hypothetical protein 0.0043 0.0034 0.017
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0135 0.0245 0.1225
Trichomonas vaginalis myosin light chain 1, putative 0.0185 0.036 0.1052
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0135 0.0245 0.0789
Giardia lamblia Cathepsin B precursor 0.1451 0.3262 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.1287 0.2885 0.8753
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.1926
Toxoplasma gondii troponin c, isotype gamma, putative 0.0185 0.036 0.1052
Echinococcus multilocularis protein patched 0.0051 0.0051 0.0033
Brugia malayi EF hand family protein 0.0185 0.036 0.036
Plasmodium falciparum serine repeat antigen 9 0.0135 0.0245 0.2816
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.0282 0.0814
Loa Loa (eye worm) calpain 0.1287 0.2885 0.2885
Trypanosoma cruzi Emopamil binding protein, putative 0.0133 0.0239 0.0221
Schistosoma mansoni calmodulin 0.0185 0.036 0.0342
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0135 0.0245 0.0697
Loa Loa (eye worm) calpain D 0.0387 0.0821 0.0821
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3412 0.7756 0.7752
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0135 0.0245 0.0226
Loa Loa (eye worm) hypothetical protein 0.0152 0.0282 0.0282
Leishmania major calmodulin, putative 0.0185 0.036 0.1102
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0387 0.0821 0.0804
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1287 0.2885 0.2872
Plasmodium falciparum serine repeat antigen 7 0.0135 0.0245 0.2816
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0185 0.036 0.0342
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0142 0.026 0.0242
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0324 0.0306
Trypanosoma brucei Calpain-like protein 1.1 0.0387 0.0821 0.1926
Giardia lamblia Encystation-specific protease 0.0135 0.0245 0.0697
Giardia lamblia Cathepsin B precursor 0.0135 0.0245 0.0697
Onchocerca volvulus 0.0152 0.0282 0.0588
Trypanosoma brucei cysteine peptidase, putative 0.0387 0.0821 0.1926
Entamoeba histolytica cysteine protease, putative 0.0142 0.026 0.1301
Echinococcus multilocularis calpain family protein 1, d 0.2512 0.5692 0.5684
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.0282 0.0814
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0387 0.0821 0.0804
Brugia malayi CHE-14 protein 0.0051 0.0051 0.0051
Plasmodium vivax serine-repeat antigen (SERA) 0.0135 0.0245 0.0789
Trichomonas vaginalis centrin, putative 0.0185 0.036 0.1052
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0133 0.0239 0.0733
Trypanosoma brucei calpain-like protein, putative 0.1287 0.2885 0.8753
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0034 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.0282 0.0814
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.0245 0.0697
Trichomonas vaginalis calmodulin, putative 0.0185 0.036 0.1052
Trichomonas vaginalis calcium binding protein, putative 0.0185 0.036 0.1052
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0135 0.0245 0.0245
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0135 0.0245 0.0226
Loa Loa (eye worm) hypothetical protein 0.0135 0.0245 0.0245
Entamoeba histolytica cysteine proteinase, putative 0.0142 0.026 0.1301
Trypanosoma cruzi cysteine peptidase, putative 0.0209 0.0413 0.0395
Loa Loa (eye worm) hypothetical protein 0.0145 0.0267 0.0267
Echinococcus multilocularis programmed cell death protein 6 0.0037 0.002 0.0002
Echinococcus granulosus neurocalcin 0.0185 0.036 0.0342
Entamoeba histolytica cysteine protease, putative 0.0152 0.0282 0.1414
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.0245 0.0697
Entamoeba histolytica cysteine protease, putative 0.0142 0.026 0.1301
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.0282 0.0814
Onchocerca volvulus 0.006 0.0071 0.0148
Schistosoma mansoni hypothetical protein 0.0049 0.0047 0.0029
Loa Loa (eye worm) hypothetical protein 0.0051 0.0051 0.0051
Leishmania major phospholipase c-like protein 0.0185 0.036 0.1102
Trypanosoma cruzi conserved protein 0.0387 0.0821 0.0804
Trypanosoma cruzi cruzipain precursor, putative 0.0209 0.0413 0.0395
Trypanosoma brucei mitochondrial calcium uptake 1 0.0185 0.036 0.0399
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.2518
Plasmodium falciparum serine repeat antigen 8 0.0135 0.0245 0.2816
Schistosoma mansoni mitochondrial solute carrier 0.0185 0.036 0.0342
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0135 0.0245 0.0226
Giardia lamblia Cathepsin L precursor 0.0135 0.0245 0.0697
Toxoplasma gondii EF hand domain-containing protein 0.0185 0.036 0.1052
Loa Loa (eye worm) fibroinase 0.0152 0.0282 0.0282
Trichomonas vaginalis calpain, putative 0.0387 0.0821 0.2475
Trypanosoma cruzi cysteine peptidase, putative 0.0142 0.026 0.0242
Plasmodium vivax vivapain-3 0.0142 0.026 0.0842
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.1845 0.183
Trichomonas vaginalis calmodulin-2, putative 0.0185 0.036 0.1052
Onchocerca volvulus 0.0135 0.0245 0.0509
Loa Loa (eye worm) calmodulin-like protein 0.0185 0.036 0.036
Echinococcus granulosus cathepsin l1 0.0145 0.0267 0.0249
Leishmania major cathepsin L-like protease 0.0209 0.0413 0.1265
Leishmania major cathepsin L-like protease 0.0152 0.0282 0.0866
Onchocerca volvulus 0.0152 0.0282 0.0588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0282 0.0814
Loa Loa (eye worm) programmed cell death protein 6 0.0186 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0062 0.0078 0.0078
Schistosoma mansoni calpain-7 (C02 family) 0.1287 0.2885 0.2872
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.2518
Trichomonas vaginalis centrin, putative 0.0185 0.036 0.1052
Trypanosoma cruzi cysteine peptidase, putative 0.0152 0.0282 0.0264
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0133 0.0239 0.0221
Leishmania major programmed cell death 6 protein-like protein 0.0185 0.036 0.1102
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0152 0.0282 0.3287
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0135 0.0245 0.0697
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.1926
Echinococcus granulosus centrin 2 0.0185 0.036 0.0342
Trypanosoma cruzi cysteine peptidase, putative 0.0209 0.0413 0.0395
Plasmodium falciparum serine repeat antigen 3 0.0135 0.0245 0.2816
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.1926
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0152 0.0282 0.0282
Trypanosoma cruzi calmodulin, putative 0.0185 0.036 0.0342
Trichomonas vaginalis hypothetical protein 0.0387 0.0821 0.2475
Brugia malayi cathepsin Z-like cysteine proteinase 0.0135 0.0245 0.0245
Trichomonas vaginalis calmodulin, putative 0.0222 0.0444 0.1311
Schistosoma mansoni patched 1 0.0051 0.0051 0.0033
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0135 0.0245 0.0245
Entamoeba histolytica calcium-binding protein, putative 0.0185 0.036 0.18
Trichomonas vaginalis calmodulin, putative 0.0185 0.036 0.1052
Brugia malayi cathepsin L precursor 0.0135 0.0245 0.0245
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0211 0.0193
Brugia malayi cathepsin L-like precursor 0.0145 0.0267 0.0267
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.2518
Giardia lamblia Cathepsin L precursor 0.0135 0.0245 0.0697
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0324 0.0306
Schistosoma mansoni cathepsin F (C01 family) 0.0145 0.0267 0.0249
Entamoeba histolytica cysteine protease, putative 0.0142 0.026 0.1301
Schistosoma mansoni cathepsin B (C01 family) 0.0135 0.0245 0.0226
Leishmania major calmodulin-like protein 0.0185 0.036 0.1102
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1287 0.2885 0.2872
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0185 0.036 0.18
Entamoeba histolytica cysteine proteinase 2 0.0142 0.026 0.1301
Plasmodium vivax vivapain-1 0.0142 0.026 0.0842
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0387 0.0821 0.0804
Plasmodium vivax centrin-1, putative 0.0185 0.036 0.119
Echinococcus granulosus calpain A 0.3598 0.8183 0.8179
Entamoeba histolytica cysteine protease, putative 0.0142 0.026 0.1301
Entamoeba histolytica hypothetical protein 0.0043 0.0034 0.017
Entamoeba histolytica calcium binding family protein 0.0185 0.036 0.18
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0135 0.0245 0.0697
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.2518
Entamoeba histolytica cysteine protease, putative 0.0135 0.0245 0.1225
Echinococcus multilocularis neuronal calcium sensor 0.0185 0.036 0.0342
Trypanosoma cruzi Emopamil binding protein, putative 0.0133 0.0239 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.0245 0.0697
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0185 0.036 0.0399
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1287 0.2885 0.2872
Brugia malayi cathepsin L-like cysteine proteinase 0.0135 0.0245 0.0245
Plasmodium falciparum serine repeat antigen 5 0.0135 0.0245 0.2816
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.2518
Trypanosoma brucei hypothetical protein 0.0387 0.0821 0.1926
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.0804
Trypanosoma cruzi kinesin, putative 0.09 0.1998 0.1983
Echinococcus granulosus calcium uptake protein 1 0.0186 0.0361 0.0343
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0135 0.0245 0.2816
Loa Loa (eye worm) hypothetical protein 0.2512 0.5692 0.5692
Trichomonas vaginalis calmodulin, putative 0.0185 0.036 0.1052
Entamoeba histolytica grainin 2 0.0037 0.0019 0.0093
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0152 0.0282 0.0264
Brugia malayi Cathepsin L-like precursor 0.0152 0.0282 0.0282
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0135 0.0245 0.0789
Giardia lamblia Cathepsin L precursor 0.0135 0.0245 0.0697
Brugia malayi calpain D 0.0387 0.0821 0.0821
Leishmania major calpain protease-like protein 0.0387 0.0821 0.2518
Leishmania major cathepsin L-like protease 0.0152 0.0282 0.0866
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1451 0.3262 1
Giardia lamblia Cathepsin B precursor 0.0135 0.0245 0.0697
Schistosoma mansoni calpain-2 (C02 family) 0.0387 0.0821 0.0804
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.0804
Entamoeba histolytica grainin 2 0.0222 0.0444 0.2221
Brugia malayi cathepsin F-like cysteine proteinase 0.0135 0.0245 0.0245
Leishmania major hypothetical protein, conserved 0.0133 0.0239 0.0733
Loa Loa (eye worm) hypothetical protein 0.0135 0.0245 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0282 0.0814
Trypanosoma brucei centrin-3 0.0222 0.0444 0.0677
Echinococcus multilocularis calbindin 32 0.0186 0.0361 0.0343
Leishmania major hypothetical protein, unknown function 0.0387 0.0821 0.2518
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0387 0.0821 0.2475
Onchocerca volvulus 0.0145 0.0267 0.0556
Onchocerca volvulus Cathepsin L homolog 0.0135 0.0245 0.0509
Entamoeba histolytica cysteine protease, putative 0.0135 0.0245 0.1225
Trypanosoma cruzi centrin, putative 0.0222 0.0444 0.0426
Entamoeba histolytica cysteine protease, putative 0.0142 0.026 0.1301
Giardia lamblia Cathepsin L-like protease 0.0135 0.0245 0.0697
Trypanosoma brucei calpain-like protein, putative 0.1287 0.2885 0.8753
Giardia lamblia Hypothetical protein 0.0186 0.0361 0.1057
Trypanosoma brucei Calpain-like protein CALP1.3 0.0387 0.0821 0.1926
Plasmodium vivax unspecified product 0.0135 0.0245 0.0789
Entamoeba histolytica cysteine proteinase 1, putative 0.0142 0.026 0.1301
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0152 0.0282 0.0814
Plasmodium falciparum serine repeat antigen 6 0.0135 0.0245 0.2816
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0387 0.0821 0.0804
Leishmania major calmodulin-like protein 0.0185 0.036 0.1102
Entamoeba histolytica cysteine protease, putative 0.0135 0.0245 0.1225
Echinococcus multilocularis programmed cell death protein 0.0222 0.0444 0.0426
Echinococcus multilocularis cathepsin L 0.0135 0.0245 0.0226
Leishmania major cathepsin L-like protease 0.0152 0.0282 0.0866
Brugia malayi Papain family cysteine protease containing protein 0.0142 0.026 0.026
Schistosoma mansoni cathepsin F (C01 family) 0.0152 0.0282 0.0264
Echinococcus granulosus cathepsin L cysteine proteinase 0.0152 0.0282 0.0264
Trichomonas vaginalis calcium binding protein, putative 0.0185 0.036 0.1052
Trypanosoma cruzi I/6 autoantigen, putative 0.0185 0.036 0.0342
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0413 0.0575
Entamoeba histolytica calmodulin, putative 0.0037 0.0019 0.0093
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1287 0.2885 0.8844
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0135 0.0245 0.0697
Entamoeba histolytica cysteine protease, putative 0.0142 0.026 0.1301
Plasmodium vivax vivapain-2 0.0152 0.0282 0.0921
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.2518
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1287 0.2885 0.2872
Echinococcus multilocularis calmodulin 0.0185 0.036 0.0342
Toxoplasma gondii cathepsin B 0.1451 0.3262 1
Entamoeba histolytica grainin, putative 0.0186 0.0361 0.1809
Loa Loa (eye worm) cysteine protease 0.0152 0.0282 0.0282
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.0804
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.0282 0.0814
Echinococcus multilocularis calpain 0.1287 0.2885 0.2872
Trichomonas vaginalis calcineurin B subunit, putative 0.0186 0.0361 0.1057
Loa Loa (eye worm) myosin regulatory light chain 1 0.0037 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0282 0.0814
Toxoplasma gondii cathepsin CPC1 0.0135 0.0245 0.0697
Leishmania major hypothetical protein, conserved 0.0186 0.0361 0.1108
Echinococcus granulosus calumenin 0.0186 0.0361 0.0343
Onchocerca volvulus 0.2125 0.4805 1
Entamoeba histolytica calpain family cysteine protease, putative 0.0387 0.0821 0.4111
Loa Loa (eye worm) hypothetical protein 0.0185 0.036 0.036
Toxoplasma gondii EFHC1, putative 0.0185 0.036 0.1052
Leishmania major calpain family cysteine protease-like protein 0.0387 0.0821 0.2518
Brugia malayi Cathepsin L-like precursor 0.0152 0.0282 0.0282
Entamoeba histolytica cysteine proteinase, putative 0.0152 0.0282 0.1414
Loa Loa (eye worm) hypothetical protein 0.0145 0.0267 0.0267
Entamoeba histolytica protein kinase, putative 0.09 0.1998 1
Echinococcus granulosus calpain 5 0.1287 0.2885 0.2872
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0135 0.0245 0.0789
Entamoeba histolytica hypothetical protein 0.0135 0.0245 0.1225
Loa Loa (eye worm) EF hand family protein 0.0185 0.036 0.036
Toxoplasma gondii cathepsin CPC2 0.0135 0.0245 0.0697
Brugia malayi calpain 5 0.0387 0.0821 0.0821
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0145 0.0267 0.0766
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0142 0.026 0.0242
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0282 0.0814
Entamoeba histolytica hypothetical protein 0.0043 0.0034 0.017
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0135 0.0245 0.0226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.026 0.0744
Plasmodium vivax hypothetical protein, conserved 0.0186 0.0361 0.1196
Echinococcus granulosus programmed cell death protein 6 0.0037 0.002 0.0002
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.3597 0.8181 0.8178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0282 0.0814
Loa Loa (eye worm) hypothetical protein 0.0037 0.0019 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0413 0.0575
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0282 0.0814
Trypanosoma cruzi kinesin, putative 0.09 0.1998 0.1983
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.026 0.0744
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0135 0.0245 0.0697
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0387 0.0821 0.0804
Schistosoma mansoni hypothetical protein 0.0043 0.0034 0.0015
Schistosoma mansoni centrin 0.0185 0.036 0.0342
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.2518
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.2518
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0413 0.0575
Brugia malayi Cathepsin L-like precursor 0.0152 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0119 0.0207 0.0207
Trypanosoma cruzi centrin, putative 0.0222 0.0444 0.0426
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0207 0.0189
Trypanosoma brucei calmodulin, putative 0.0185 0.036 0.0399
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0034 0.0015
Giardia lamblia Cathepsin L precursor 0.0135 0.0245 0.0697
Echinococcus granulosus calpain 0.1287 0.2885 0.2872
Echinococcus multilocularis expressed conserved protein 0.0112 0.019 0.0172
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0135 0.0245 0.0789
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0387 0.0821 0.2475
Entamoeba histolytica cysteine protease, putative 0.0135 0.0245 0.1225
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0413 0.0575
Echinococcus multilocularis tumor protein p63 0.0408 0.087 0.0853
Echinococcus multilocularis EF hand domain containing family member A2 0.0185 0.036 0.0342
Brugia malayi Papain family cysteine protease containing protein 0.0142 0.026 0.026
Trichomonas vaginalis calmodulin, putative 0.0185 0.036 0.1052
Giardia lamblia Cathepsin B precursor 0.1451 0.3262 1
Toxoplasma gondii calmodulin CAM1 0.0186 0.0361 0.1057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.0282 0.0814
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1287 0.2885 0.2872
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1451 0.3262 1
Entamoeba histolytica cysteine protease, putative 0.0142 0.026 0.1301
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1451 0.3262 0.3249
Toxoplasma gondii calcium-dependent protein kinase 0.0186 0.0361 0.1057
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0051 0.0033
Onchocerca volvulus 0.0037 0.0019 0.0039
Loa Loa (eye worm) calpain 5 0.09 0.1998 0.1998
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3597 0.8181 0.8178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.026 0.0069
Echinococcus granulosus calmodulin 0.0185 0.036 0.0342
Trypanosoma brucei I/6 autoantigen 0.0185 0.036 0.0399
Schistosoma mansoni reticulocalbin 0.0185 0.036 0.0342
Plasmodium falciparum centrin-1 0.0185 0.036 0.4248
Schistosoma mansoni neuronal calcium sensor 0.0185 0.036 0.0342
Schistosoma mansoni calpain C (C02 family) 0.1287 0.2885 0.2872
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0152 0.0282 0.3287
Entamoeba histolytica calmodulin, putative 0.0185 0.036 0.18
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0135 0.0245 0.0226
Echinococcus multilocularis cysteine protease 0.0152 0.0282 0.0264
Loa Loa (eye worm) hypothetical protein 0.0387 0.0821 0.0821
Echinococcus multilocularis cathepsin L 0.0142 0.026 0.0242
Giardia lamblia Hypothetical protein 0.0135 0.0245 0.0697
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0185 0.036 0.119
Echinococcus granulosus neuronal calcium sensor 0.0185 0.036 0.0342
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0185 0.036 0.0342
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.036 0.1052
Echinococcus multilocularis neurocalcin 0.0185 0.036 0.0342
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0185 0.036 0.0399
Leishmania major protein kinase, putative 0.0185 0.036 0.1102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0282 0.0814
Onchocerca volvulus 0.0152 0.0282 0.0588
Echinococcus granulosus programmed cell death protein 0.0222 0.0444 0.0426
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0135 0.0245 0.0226
Schistosoma mansoni hypothetical protein 0.0387 0.0821 0.0804
Trypanosoma cruzi centrin-3 0.0222 0.0444 0.0426
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0135 0.0245 0.0226
Trypanosoma brucei protein I/6 0.0185 0.036 0.0399
Loa Loa (eye worm) hypothetical protein 0.0145 0.0267 0.0267
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0145 0.0267 0.0766
Entamoeba histolytica cysteine protease, putative 0.0135 0.0245 0.1225
Trypanosoma brucei calpain-like protein, putative 0.1287 0.2885 0.8753
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0152 0.0282 0.0814
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.1287 0.2885 0.8844
Onchocerca volvulus 0.0152 0.0282 0.0588
Loa Loa (eye worm) calpain family protein 1 0.3412 0.7756 0.7756
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0135 0.0245 0.0789
Onchocerca volvulus 0.0186 0.0361 0.0752
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0282 0.0814
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0135 0.0245 0.0789
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3597 0.8181 0.8178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.0245 0.0697
Trypanosoma brucei centrin, putative 0.0185 0.036 0.0399
Schistosoma mansoni cathepsin C 0.0135 0.0245 0.0226
Plasmodium falciparum cysteine proteinase falcipain 3 0.0152 0.0282 0.3287
Trypanosoma brucei antigen, putative 0.1287 0.2885 0.8753
Brugia malayi Calmodulin-like protein 0.0185 0.036 0.036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.0282 0.0814
Brugia malayi calpain family protein 1 0.3412 0.7756 0.7756
Loa Loa (eye worm) hypothetical protein 0.0135 0.0245 0.0245
Trypanosoma brucei calmodulin, putative 0.0186 0.0361 0.0405
Brugia malayi Cathepsin L-like precursor 0.0145 0.0267 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0051 0.0101
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0387 0.0821 0.0804
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0135 0.0245 0.0697
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0185 0.036 0.1052
Loa Loa (eye worm) cathepsin B 0.1451 0.3262 0.3262
Loa Loa (eye worm) hypothetical protein 0.0037 0.0019 0.0019
Brugia malayi Papain family cysteine protease containing protein 0.0152 0.0282 0.0282
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0135 0.0245 0.1225
Entamoeba histolytica cysteine protease, putative 0.0142 0.026 0.1301
Trypanosoma cruzi cysteine peptidase, putative 0.0209 0.0413 0.0395
Trichomonas vaginalis calpain, putative 0.0387 0.0821 0.2475
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0185 0.036 0.0342
Schistosoma mansoni hypothetical protein 0.0185 0.036 0.0342
Entamoeba histolytica cysteine protease, putative 0.0135 0.0245 0.1225
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0186 0.0361 0.0343
Brugia malayi calcium-binding protein 0.0185 0.036 0.036
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0186 0.0361 0.0343
Echinococcus granulosus microtubule associated protein 2 0.0833 0.1845 0.183
Giardia lamblia Cathepsin B precursor 0.0135 0.0245 0.0697
Leishmania major cathepsin L-like protease 0.0152 0.0282 0.0866
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0207 0.1036
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0152 0.0282 0.0282
Onchocerca volvulus Cathepsin L homolog 0.0152 0.0282 0.0588
Brugia malayi RasGEF domain containing protein 0.0037 0.0019 0.0019
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0071 0.0053
Schistosoma mansoni ef hand domain family member A2 0.0185 0.036 0.0342
Entamoeba histolytica cysteine protease, putative 0.0142 0.026 0.1301
Echinococcus multilocularis calcium uptake protein 1 0.0186 0.0361 0.0343
Brugia malayi Cathepsin L-like precursor 0.0152 0.0282 0.0282
Leishmania major calcineurin B subunit, putative 0.0185 0.036 0.1102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.0245 0.0697
Trypanosoma brucei Component of motile flagella 41 0.0185 0.036 0.0399
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.0037 0.0019 0.0039
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0185 0.036 0.0342
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0413 0.0575
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0185 0.036 0.1052
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0387 0.0821 0.1926
Entamoeba histolytica hypothetical protein 0.0043 0.0034 0.017
Schistosoma mansoni calmodulin related calcium binding protein 0.0185 0.036 0.0342
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0282 0.0814
Entamoeba histolytica cysteine proteinase, putative 0.0145 0.0267 0.1337
Giardia lamblia Cathepsin L precursor 0.0135 0.0245 0.0697
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0135 0.0245 0.0245
Trypanosoma cruzi cysteine proteinase, putative 0.0142 0.026 0.0242
Leishmania major centrin, putative,caltractin, putative 0.0185 0.036 0.1102
Trichomonas vaginalis calcium binding protein, putative 0.0185 0.036 0.1052
Echinococcus multilocularis calpain A 0.3598 0.8183 0.8179
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0135 0.0245 0.0697
Echinococcus granulosus tumor protein p63 0.0408 0.087 0.0853
Entamoeba histolytica cysteine protease, putative 0.0142 0.026 0.1301
Plasmodium falciparum serine repeat antigen 2 0.0135 0.0245 0.2816
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1287 0.2885 0.2872
Onchocerca volvulus Cathepsin F homolog 0.0152 0.0282 0.0588
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0142 0.026 0.0242
Giardia lamblia Cysteine protease 0.0135 0.0245 0.0697
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0387 0.0821 0.1926
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0133 0.0239 0.0221
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1287 0.2885 0.2872
Schistosoma mansoni Mername-AA248 (C02 family) 0.1287 0.2885 0.2872
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0135 0.0245 0.0789
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0135 0.0245 0.0697
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.026 0.0069
Loa Loa (eye worm) hypothetical protein 0.0185 0.036 0.036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0135 0.0245 0.0697
Entamoeba histolytica cysteine proteinase, putative 0.0152 0.0282 0.1414
Loa Loa (eye worm) hypothetical protein 0.3412 0.7756 0.7756
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.2518
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0135 0.0245 0.0245
Schistosoma mansoni neuronal calcium sensor 0.0185 0.036 0.0342
Toxoplasma gondii preprocathepsin c precursor, putative 0.0135 0.0245 0.0697
Trichomonas vaginalis calcium binding protein, putative 0.0222 0.0444 0.1311
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0387 0.0821 0.2475
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0202 0.0397 0.038
Plasmodium falciparum cysteine proteinase falcipain 1 0.0142 0.026 0.3007
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0387 0.0821 0.2475
Trypanosoma cruzi cysteine proteinase, putative 0.0142 0.026 0.0242
Echinococcus multilocularis cathepsin L cysteine protease 0.0152 0.0282 0.0264
Onchocerca volvulus 0.0185 0.036 0.0748
Trypanosoma brucei Calpain-like protein 1.2 0.0387 0.0821 0.1926
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.0245 0.0697
Brugia malayi Myosin regulatory light chain 1 0.0037 0.0019 0.0019
Toxoplasma gondii centrin 0.0185 0.036 0.1052
Plasmodium vivax vivapain-2 0.0152 0.0282 0.0921
Onchocerca volvulus 0.0185 0.036 0.0748
Trypanosoma cruzi calmodulin, putative 0.0185 0.036 0.0342
Entamoeba histolytica cysteine protease, putative 0.0142 0.026 0.1301
Trypanosoma brucei Calpain-like protein 2 0.0387 0.0821 0.1926
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0387 0.0821 0.0804
Brugia malayi Papain family cysteine protease containing protein 0.0135 0.0245 0.0245
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0051 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0387 0.0821 0.2475
Leishmania major cathepsin L-like protease 0.0209 0.0413 0.1265
Brugia malayi calpain 7 0.1287 0.2885 0.2885
Trypanosoma brucei calpain-like protein, putative 0.1287 0.2885 0.8753
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0152 0.0282 0.0264
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0207 0.0207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0413 0.0575
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.2179 0.2165
Echinococcus granulosus cysteine protease 0.0142 0.026 0.0242
Brugia malayi Neuronal calcium sensor family protein 1 0.0037 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0037 0.0019 0.0019
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0142 0.026 0.0242
Giardia lamblia Cathepsin B precursor 0.0135 0.0245 0.0697
Loa Loa (eye worm) hypothetical protein 0.0135 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.3025 0.6869 0.6869
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0185 0.036 0.18
Leishmania major hypothetical protein, conserved 0.0387 0.0821 0.2518
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0135 0.0245 0.0789
Entamoeba histolytica calpain large subunit domain III containing protein 0.09 0.1998 1
Brugia malayi programmed cell death protein 6 0.0185 0.036 0.036
Schistosoma mansoni neuronal calcium sensor 0.0185 0.036 0.0342
Echinococcus multilocularis EF hand domain containing family member A2 0.0186 0.0361 0.0343
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.2518
Brugia malayi calpain family protein 1 0.3412 0.7756 0.7756
Loa Loa (eye worm) myosin Light Chain family member 0.0037 0.002 0.002
Schistosoma mansoni neuronal calcium sensor 0.0185 0.036 0.0342
Schistosoma mansoni centrin-related 0.0185 0.036 0.0342
Entamoeba histolytica cysteine protease, putative 0.0142 0.026 0.1301
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.2518
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1287 0.2885 0.8844
Schistosoma mansoni calmodulin 0.0185 0.036 0.0342
Trypanosoma cruzi major cysteine proteinase, putative 0.0135 0.0245 0.0226
Brugia malayi hypothetical protein 0.0043 0.0034 0.0034
Echinococcus granulosus cathepsin L 0.0142 0.026 0.0242
Echinococcus multilocularis calpain 7 (C02 family) 0.1287 0.2885 0.2872
Echinococcus granulosus calbindin 32 0.0186 0.0361 0.0343
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.0804
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0051 0.0033
Loa Loa (eye worm) hypothetical protein 0.0135 0.0245 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0282 0.0814
Toxoplasma gondii hypothetical protein 0.0387 0.0821 0.2475
Trypanosoma brucei hypothetical protein, conserved 0.0185 0.036 0.0399
Echinococcus multilocularis calpain 5 0.1287 0.2885 0.2872
Leishmania major hypothetical protein, conserved 0.0185 0.036 0.1102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0282 0.0814
Giardia lamblia Cysteine protease 0.0135 0.0245 0.0697
Trypanosoma cruzi calmodulin, putative 0.0185 0.036 0.0342
Echinococcus multilocularis cathepsin L cysteine protease 0.0152 0.0282 0.0264
Schistosoma mansoni hypothetical protein 0.0049 0.0047 0.0029
Schistosoma mansoni cathepsin F (C01 family) 0.0152 0.0282 0.0264
Onchocerca volvulus 0.0152 0.0282 0.0588
Giardia lamblia Cathepsin B precursor 0.1451 0.3262 1
Loa Loa (eye worm) hypothetical protein 0.2125 0.4805 0.4805
Schistosoma mansoni cathepsin S (C01 family) 0.0135 0.0245 0.0226
Trypanosoma brucei calpain, putative 0.0387 0.0821 0.1926
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.0804
Echinococcus multilocularis calumenin 0.0186 0.0361 0.0343
Brugia malayi EF hand family protein 0.0186 0.0361 0.0361
Echinococcus granulosus EF HAND 1 calcium binding site 0.0185 0.036 0.0342
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.2518
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0135 0.0245 0.0226
Leishmania major cysteine peptidase A (CPA) 0.0152 0.0282 0.0866
Brugia malayi cathepsin Z-like cysteine proteinase 0.0135 0.0245 0.0245
Onchocerca volvulus 0.0152 0.0282 0.0588
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0413 0.0575
Leishmania major centrin, putative 0.0185 0.036 0.1102
Schistosoma mansoni calpain (C02 family) 0.1287 0.2885 0.2872
Plasmodium falciparum serine repeat antigen 1 0.0135 0.0245 0.2816
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0413 0.0575
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1287 0.2885 0.2872
Loa Loa (eye worm) calpain family protein 1 0.2512 0.5692 0.5692
Toxoplasma gondii cathepsin CPL 0.0152 0.0282 0.0814
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0207 0.0189
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0387 0.0821 0.2475
Echinococcus granulosus cathepsin L 0.0135 0.0245 0.0226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.0245 0.0697
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.0804
Trichomonas vaginalis calmodulin, putative 0.0186 0.0361 0.1057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0413 0.0575
Loa Loa (eye worm) ctsf protein 0.0152 0.0282 0.0282
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0135 0.0245 0.2816
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0135 0.0245 0.0697
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.1845 0.183
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0135 0.0245 0.0697
Entamoeba histolytica hypothetical protein, conserved 0.0186 0.0361 0.1809
Brugia malayi Cathepsin L-like precursor 0.0152 0.0282 0.0282
Brugia malayi Cathepsin L-like precursor 0.0145 0.0267 0.0267
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0135 0.0245 0.0789
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0282 0.0814
Echinococcus multilocularis programmed cell death protein 0.0222 0.0444 0.0426
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0185 0.036 0.0342
Echinococcus multilocularis hypothetical protein 0.1287 0.2885 0.2872
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0387 0.0821 0.0804
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.1287 0.2885 0.8753
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0135 0.0245 0.0697
Giardia lamblia Hypothetical protein 0.0135 0.0245 0.0697
Trypanosoma brucei cysteine peptidase C (CPC) 0.1451 0.3262 1
Giardia lamblia Cathepsin B precursor 0.0135 0.0245 0.0697
Echinococcus granulosus EF hand domain containing family member A2 0.0185 0.036 0.0342
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0387 0.0821 0.0804
Toxoplasma gondii centrin, putative 0.0185 0.036 0.1052
Trypanosoma cruzi calpain cysteine peptidase, putative 0.1287 0.2885 0.2872
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.2518
Schistosoma mansoni rab 0.0185 0.036 0.0342
Echinococcus granulosus expressed conserved protein 0.0112 0.019 0.0172
Plasmodium vivax serine-repeat antigen (SERA) 0.0135 0.0245 0.0789
Schistosoma mansoni hypothetical protein 0.0049 0.0047 0.0029
Onchocerca volvulus 0.0152 0.0282 0.0588
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.0804
Trichomonas vaginalis calpain, putative 0.0387 0.0821 0.2475
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0037 0.0019 0.0039
Trypanosoma cruzi I/6 autoantigen, putative 0.0185 0.036 0.0342
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1287 0.2885 0.2872
Trypanosoma brucei calpain, putative 0.0387 0.0821 0.1926
Echinococcus granulosus cathepsin l cysteine peptidase 0.0152 0.0282 0.0264
Trypanosoma brucei caltractin, putative 0.0222 0.0444 0.0677
Schistosoma mansoni calpain-7 (C02 family) 0.1287 0.2885 0.2872
Echinococcus granulosus cathepsin L cysteine protease 0.0142 0.026 0.0242
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0051 0.0051
Brugia malayi Probable myosin regulatory light chain 0.0037 0.002 0.002
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0387 0.0821 0.1926
Echinococcus granulosus EF hand domain containing family member A2 0.0186 0.0361 0.0343
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.0804
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.2518
Entamoeba histolytica cysteine protease, putative 0.0142 0.026 0.1301
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0185 0.036 0.0342
Loa Loa (eye worm) hypothetical protein 0.006 0.0071 0.0071
Trichomonas vaginalis calmodulin, putative 0.0185 0.036 0.1052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0282 0.0814
Plasmodium vivax calpain, putative 0.1287 0.2885 1
Giardia lamblia Cysteine protease 0.0135 0.0245 0.0697
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0282 0.0814
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0135 0.0245 0.2816
Giardia lamblia Cysteine protease 0.0135 0.0245 0.0697
Brugia malayi calpain 5 0.09 0.1998 0.1998
Entamoeba histolytica cysteine proteinase, putative 0.0142 0.026 0.1301
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0135 0.0245 0.0789
Entamoeba histolytica calmodulin, putative 0.0185 0.036 0.18
Brugia malayi Cathepsin L-like precursor 0.0152 0.0282 0.0282
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0387 0.0821 0.2475
Onchocerca volvulus Cathepsin L homolog 0.0152 0.0282 0.0588
Trypanosoma brucei kinesin, putative 0.09 0.1998 0.5818
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.2518
Leishmania major cathepsin L-like protease 0.0209 0.0413 0.1265
Schistosoma mansoni hypothetical protein 0.0049 0.0047 0.0029
Plasmodium falciparum serine repeat antigen 4 0.0135 0.0245 0.2816
Entamoeba histolytica cysteine proteinase, putative 0.0142 0.026 0.1301
Brugia malayi Cathepsin L-like cysteine proteinase 0.0145 0.0267 0.0267
Entamoeba histolytica cysteine proteinase, putative 0.0142 0.026 0.1301
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0387 0.0821 0.2518
Plasmodium vivax unspecified product 0.0142 0.026 0.0842
Brugia malayi fibroinase precursor 0.0135 0.0245 0.0245
Onchocerca volvulus 0.0037 0.0019 0.0039
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0034 0.0015
Trypanosoma cruzi major cysteine proteinase, putative 0.0192 0.0375 0.0357
Trichomonas vaginalis calcineurin B subunit, putative 0.0185 0.036 0.1052
Schistosoma mansoni reticulocalbin 0.0186 0.0361 0.0343
Echinococcus multilocularis centrin 2 0.0185 0.036 0.0342
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0413 0.0575
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0185 0.036 0.0342
Trichomonas vaginalis calmodulin, putative 0.0185 0.036 0.1052
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0135 0.0245 0.0697
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.3597 0.8181 0.8178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0135 0.0245 0.0697
Echinococcus multilocularis cysteine protease 0.0152 0.0282 0.0264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0413 0.0575
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0135 0.0245 0.0226
Loa Loa (eye worm) hypothetical protein 0.0135 0.0245 0.0245
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.0282 0.0814
Plasmodium falciparum calpain 0.0387 0.0821 1
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.036 0.1052
Echinococcus granulosus cathepsin l1 0.0152 0.0282 0.0264
Leishmania major cathepsin L-like protease 0.0152 0.0282 0.0866
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0135 0.0245 0.0697
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0387 0.0821 0.2475
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.0282 0.0814
Schistosoma mansoni hypothetical protein 0.0185 0.036 0.0342
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0387 0.0821 0.0804
Leishmania major i/6 autoantigen-like protein 0.0185 0.036 0.1102
Onchocerca volvulus 0.0133 0.0239 0.0497
Leishmania major kinesin, putative 0.09 0.1998 0.6125
Brugia malayi Papain family cysteine protease containing protein 0.0135 0.0245 0.0245
Brugia malayi Papain family cysteine protease containing protein 0.0135 0.0245 0.0245
Trypanosoma cruzi cysteine protease, putative 0.0142 0.026 0.0242

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3162 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.1735 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 6.012 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (binding) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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