Detailed information for compound 1406928

Basic information

Technical information
  • TDR Targets ID: 1406928
  • Name: 5-[2-(1,3-benzothiazol-2-ylsulfanyl)acetyl]-5 -methyloxolan-2-one hydrobromide
  • MW: 388.3 | Formula: C14H14BrNO3S2
  • H donors: 0 H acceptors: 3 LogP: 4.16 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCC(O1)(C)C(=O)CSc1nc2c(s1)cccc2.Br
  • InChi: 1S/C14H13NO3S2.BrH/c1-14(7-6-12(17)18-14)11(16)8-19-13-15-9-4-2-3-5-10(9)20-13;/h2-5H,6-8H2,1H3;1H
  • InChiKey: KOLQDNQYRGOBBT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-[2-(1,3-benzothiazol-2-ylsulfanyl)acetyl]-5-methyl-tetrahydrofuran-2-one hydrobromide
  • 5-[2-(1,3-benzothiazol-2-ylthio)-1-oxoethyl]-5-methyl-2-tetrahydrofuranone hydrobromide
  • 5-[2-(1,3-benzothiazol-2-ylthio)acetyl]-5-methyl-tetrahydrofuran-2-one hydrobromide
  • 5-[2-(1,3-benzothiazol-2-ylsulfanyl)ethanoyl]-5-methyl-oxolan-2-one hydrobromide
  • MLS000080198
  • SMR000037349

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.2303
Schistosoma mansoni reticulocalbin 0.0041 0.016 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0338 0.2921 0.9261
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0364 0.3155 1
Trichomonas vaginalis calmodulin, putative 0.0041 0.016 0.0229
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0364 0.3155 0.3093
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0041 0.016 0.0372
Plasmodium vivax centrin-1, putative 0.0041 0.016 0.0248
Trypanosoma brucei cysteine peptidase C (CPC) 0.0364 0.3155 1
Brugia malayi Cathepsin L-like precursor 0.0033 0.0089 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.016 0.0229
Leishmania major i/6 autoantigen-like protein 0.0041 0.016 0.0506
Brugia malayi Cathepsin L-like precursor 0.0033 0.0089 0.0089
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0102 0.0726 0.0726
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0338 0.2921 0.2921
Trypanosoma brucei Calpain-like protein 2 0.0102 0.0726 0.2303
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0897 0.8103 0.8086
Schistosoma mansoni calpain-2 (C02 family) 0.0102 0.0726 0.0643
Schistosoma mansoni centrin-related 0.0041 0.016 0.0071
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0033 0.0089 0.0089
Echinococcus granulosus calpain 0.0338 0.2921 0.2857
Schistosoma mansoni reticulocalbin 0.0041 0.016 0.0071
Trichomonas vaginalis calmodulin, putative 0.0041 0.016 0.0229
Brugia malayi calpain family protein 1 0.0897 0.8103 0.8103
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0089 0.0089
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0338 0.2921 0.2921
Plasmodium vivax calpain, putative 0.0338 0.2921 1
Trypanosoma brucei calpain-like protein, putative 0.0338 0.2921 0.9261
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0041 0.016 0.0506
Loa Loa (eye worm) hypothetical protein 0.0033 0.0089 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0089 0.0284
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0089 0.0284
Plasmodium vivax hypothetical protein, conserved 0.0041 0.016 0.0248
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0041 0.016 0.016
Schistosoma mansoni neuronal calcium sensor 0.0041 0.016 0.0071
Toxoplasma gondii centrin, putative 0.0041 0.016 0.0229
Echinococcus granulosus calpain 7 C02 family 0.0338 0.2921 0.2857
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.026 0.0558
Leishmania major cysteine peptidase A (CPA) 0.0033 0.0089 0.0284
Loa Loa (eye worm) hypothetical protein 0.0897 0.8103 0.8103
Trichomonas vaginalis calmodulin, putative 0.0041 0.016 0.0229
Toxoplasma gondii centrin 0.0041 0.016 0.0229
Leishmania major cathepsin L-like protease 0.0033 0.0089 0.0284
Leishmania major calmodulin, putative 0.0041 0.016 0.0506
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0338 0.2921 0.2921
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0089 0.0284
Leishmania major hypothetical protein, conserved 0.0041 0.016 0.0506
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0041 0.016 0.016
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0041 0.016 0.0071
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0089 0.0089
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0938 0.848 0.8466
Loa Loa (eye worm) calmodulin-like protein 0.0041 0.016 0.016
Echinococcus multilocularis calcium uptake protein 1 0.0041 0.016 0.0071
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0089 0.0089
Leishmania major hypothetical protein, conserved 0.0041 0.016 0.0506
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.2303
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0199 0.0199
Echinococcus multilocularis programmed cell death protein 0.0041 0.016 0.0071
Echinococcus multilocularis centrin 2 0.0041 0.016 0.0071
Loa Loa (eye worm) hypothetical protein 0.0033 0.0089 0.0089
Trypanosoma cruzi calmodulin, putative 0.0041 0.016 0.016
Toxoplasma gondii EF hand domain-containing protein 0.0041 0.016 0.0229
Brugia malayi Cathepsin L-like precursor 0.0033 0.0089 0.0089
Trichomonas vaginalis calcium binding protein, putative 0.0041 0.016 0.0229
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0938 0.848 0.8466
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1406 0.1329
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0102 0.0726 0.2078
Toxoplasma gondii EFHC1, putative 0.0041 0.016 0.0229
Plasmodium falciparum centrin-1 0.0041 0.016 0.1103
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0102 0.0732 0.2321
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0199 0.011
Toxoplasma gondii calmodulin CAM1 0.0041 0.016 0.0229
Toxoplasma gondii calcium-dependent protein kinase 0.0041 0.016 0.0229
Leishmania major cathepsin L-like protease 0.0033 0.0089 0.0284
Schistosoma mansoni neuronal calcium sensor 0.0041 0.016 0.0071
Leishmania major cathepsin L-like protease 0.0033 0.0089 0.0284
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0089 0.0284
Trypanosoma brucei kinesin, putative 0.0237 0.1978 0.627
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1361 0.1283
Onchocerca volvulus 0.0041 0.016 0.0144
Giardia lamblia Hypothetical protein 0.0041 0.016 0.0229
Echinococcus multilocularis calmodulin 0.0041 0.016 0.0071
Entamoeba histolytica hypothetical protein 0.0035 0.011 0.011
Toxoplasma gondii troponin c, isotype gamma, putative 0.0041 0.016 0.0229
Loa Loa (eye worm) hypothetical protein 0.066 0.5908 0.5908
Brugia malayi calpain D 0.0102 0.0726 0.0726
Loa Loa (eye worm) hypothetical protein 0.0033 0.0089 0.0089
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.0726
Leishmania major programmed cell death 6 protein-like protein 0.0041 0.016 0.0506
Entamoeba histolytica hypothetical protein, conserved 0.0041 0.016 0.0372
Leishmania major calpain family cysteine protease-like protein 0.0102 0.0726 0.2303
Leishmania major centrin, putative,caltractin, putative 0.0041 0.016 0.0506
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0041 0.016 0.0071
Loa Loa (eye worm) hypothetical protein 0.0041 0.016 0.016
Trypanosoma brucei calmodulin, putative 0.0041 0.016 0.0506
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0041 0.016 0.0229
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.011 0.0021
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0338 0.2921 0.2921
Trichomonas vaginalis calmodulin, putative 0.0041 0.016 0.0229
Brugia malayi Cathepsin L-like cysteine proteinase 0.0033 0.0089 0.0089
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0089 0.0089
Trypanosoma cruzi major cysteine proteinase, putative 0.0033 0.0089 0.0089
Brugia malayi calpain 5 0.0102 0.0726 0.0726
Brugia malayi cathepsin Z-like cysteine proteinase 0.0033 0.0089 0.0089
Schistosoma mansoni calmodulin related calcium binding protein 0.0041 0.016 0.0071
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0102 0.0726 0.2078
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0041 0.016 0.0372
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0102 0.0726 0.2303
Trichomonas vaginalis calmodulin, putative 0.0041 0.016 0.0229
Entamoeba histolytica calmodulin, putative 0.0041 0.016 0.0372
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0102 0.0726 0.0726
Trichomonas vaginalis calpain, putative 0.0102 0.0726 0.2078
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0089 0.0089
Schistosoma mansoni calmodulin 0.0041 0.016 0.0071
Schistosoma mansoni neuronal calcium sensor 0.0041 0.016 0.0071
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.2303
Trypanosoma cruzi calmodulin, putative 0.0041 0.016 0.016
Trypanosoma brucei Calpain-like protein 1.2 0.0102 0.0726 0.2303
Trypanosoma cruzi cruzipain precursor, putative 0.0033 0.0089 0.0089
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0089 0.0089
Brugia malayi Calmodulin-like protein 0.0041 0.016 0.016
Schistosoma mansoni centrin 0.0041 0.016 0.0071
Trichomonas vaginalis calcium binding protein, putative 0.0041 0.016 0.0229
Trichomonas vaginalis calpain, putative 0.0102 0.0726 0.2078
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.026 0.0558
Leishmania major calpain protease-like protein 0.0102 0.0726 0.2303
Trypanosoma cruzi I/6 autoantigen, putative 0.0041 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0033 0.0089 0.0089
Entamoeba histolytica grainin, putative 0.0041 0.016 0.0372
Leishmania major hypothetical protein, conserved 0.0102 0.0726 0.2303
Trichomonas vaginalis calcium binding protein, putative 0.0041 0.016 0.0229
Trypanosoma cruzi kinesin, putative 0.0237 0.1978 0.1978
Trichomonas vaginalis centrin, putative 0.0041 0.016 0.0229
Trypanosoma brucei mitochondrial calcium uptake 1 0.0041 0.016 0.0506
Echinococcus multilocularis calpain 5 0.0338 0.2921 0.2857
Loa Loa (eye worm) hypothetical protein 0.0033 0.0089 0.0089
Leishmania major cathepsin L-like protease 0.0033 0.0089 0.0284
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.0726
Echinococcus multilocularis EF hand domain containing family member A2 0.0041 0.016 0.0071
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0033 0.0089 0.0089
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.2303
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.2303
Leishmania major phospholipase c-like protein 0.0041 0.016 0.0506
Brugia malayi calpain family protein 1 0.0897 0.8103 0.8103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0089 0.0284
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0089 0.0284
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.016 0.0229
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0041 0.016 0.016
Trypanosoma brucei antigen, putative 0.0338 0.2921 0.9261
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0102 0.0726 0.0726
Brugia malayi calpain 7 0.0338 0.2921 0.2921
Leishmania major cathepsin L-like protease 0.0033 0.0089 0.0284
Brugia malayi Cathepsin L-like precursor 0.0033 0.0089 0.0089
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0116 0.0116
Echinococcus granulosus calpain A 0.0338 0.2921 0.2857
Echinococcus granulosus neurocalcin 0.0041 0.016 0.0071
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.0726
Loa Loa (eye worm) calpain family protein 1 0.0897 0.8103 0.8103
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0041 0.016 0.0071
Loa Loa (eye worm) calpain family protein 1 0.066 0.5908 0.5908
Entamoeba histolytica grainin 2 0.0041 0.016 0.0372
Onchocerca volvulus 0.0041 0.016 0.0144
Brugia malayi hypothetical protein 0.0296 0.2532 0.2532
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0102 0.0726 0.2078
Trichomonas vaginalis calmodulin, putative 0.0041 0.016 0.0229
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0102 0.0726 0.0726
Leishmania major centrin, putative 0.0041 0.016 0.0506
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.0726
Leishmania major kinesin, putative 0.0237 0.1978 0.627
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.026 0.0558
Loa Loa (eye worm) hypothetical protein 0.0102 0.0726 0.0726
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0364 0.3155 0.3155
Echinococcus granulosus geminin 0.0166 0.1324 0.1246
Entamoeba histolytica calpain family cysteine protease, putative 0.0102 0.0726 0.3373
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0338 0.2921 0.2921
Entamoeba histolytica hypothetical protein 0.0035 0.011 0.011
Trichomonas vaginalis calmodulin, putative 0.0041 0.016 0.0229
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0102 0.0726 0.2078
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.2303
Brugia malayi cathepsin F-like cysteine proteinase 0.0033 0.0089 0.0089
Brugia malayi cathepsin L-like precursor 0.0033 0.0089 0.0089
Leishmania major calmodulin-like protein 0.0041 0.016 0.0506
Trichomonas vaginalis calcineurin B subunit, putative 0.0041 0.016 0.0229
Onchocerca volvulus 0.0296 0.2532 0.5009
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0089 0.0089
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0199 0.011
Schistosoma mansoni calpain-7 (C02 family) 0.0338 0.2921 0.2857
Trichomonas vaginalis calcium binding protein, putative 0.0041 0.016 0.0229
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.026 0.0172
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0041 0.016 0.016
Echinococcus granulosus calpain 5 0.0338 0.2921 0.2857
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0338 0.2921 0.2921
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0089 0.0284
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.2303
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0726 0.2078
Echinococcus multilocularis hypothetical protein 0.0338 0.2921 0.2857
Trichomonas vaginalis calcineurin B subunit, putative 0.0041 0.016 0.0229
Loa Loa (eye worm) hypothetical protein 0.0795 0.7159 0.7159
Brugia malayi calcium-binding protein 0.0041 0.016 0.016
Trypanosoma cruzi centrin-3 0.0041 0.016 0.016
Plasmodium falciparum calpain 0.0102 0.0726 1
Loa Loa (eye worm) programmed cell death protein 6 0.0041 0.016 0.016
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0938 0.848 0.8466
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0102 0.0726 0.0726
Schistosoma mansoni ef hand domain family member A2 0.0041 0.016 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.2303
Echinococcus granulosus calcium uptake protein 1 0.0041 0.016 0.0071
Trypanosoma brucei Component of motile flagella 41 0.0041 0.016 0.0506
Loa Loa (eye worm) hypothetical protein 0.0559 0.4964 0.4964
Toxoplasma gondii cathepsin B 0.0364 0.3155 1
Trypanosoma brucei centrin, putative 0.0041 0.016 0.0506
Trypanosoma cruzi conserved protein 0.0102 0.0726 0.0726
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0041 0.016 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0089 0.0284
Brugia malayi Cathepsin L-like precursor 0.0033 0.0089 0.0089
Brugia malayi cathepsin L precursor 0.0033 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0033 0.0089 0.0089
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0338 0.2921 0.9261
Trypanosoma cruzi centrin, putative 0.0041 0.016 0.016
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0199 0.0199
Brugia malayi cathepsin Z-like cysteine proteinase 0.0033 0.0089 0.0089
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0338 0.2921 0.2921
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.2303
Trypanosoma cruzi major cysteine proteinase, putative 0.0033 0.0089 0.0089
Trypanosoma brucei Calpain-like protein 1.1 0.0102 0.0726 0.2303
Trypanosoma cruzi cysteine protease, putative 0.0033 0.0089 0.0089
Entamoeba histolytica calcium binding family protein 0.0041 0.016 0.0372
Leishmania major calmodulin-like protein 0.0041 0.016 0.0506
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0338 0.2921 0.9261
Loa Loa (eye worm) calpain 0.0338 0.2921 0.2921
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.2303
Echinococcus multilocularis calmodulin 0.0041 0.016 0.0071
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0102 0.0726 0.2078
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0338 0.2921 0.9261
Echinococcus granulosus EF hand domain containing family member A2 0.0041 0.016 0.0071
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.026 0.0603
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.0726
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.2303
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0089 0.0089
Echinococcus granulosus centrin 2 0.0041 0.016 0.0071
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.2303
Loa Loa (eye worm) fibroinase 0.0033 0.0089 0.0089
Trypanosoma brucei centrin-3 0.0041 0.016 0.0506
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0089 0.0284
Schistosoma mansoni hypothetical protein 0.0041 0.016 0.0071
Brugia malayi EF hand family protein 0.0041 0.016 0.016
Trypanosoma brucei hypothetical protein 0.0102 0.0726 0.2303
Brugia malayi Cytochrome P450 family protein 0.0036 0.0116 0.0116
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1406 0.1329
Loa Loa (eye worm) hypothetical protein 0.0041 0.016 0.016
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.011 0.0021
Schistosoma mansoni hypothetical protein 0.0035 0.011 0.0021
Brugia malayi programmed cell death protein 6 0.0041 0.016 0.016
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0102 0.0726 0.0726
Trypanosoma brucei calpain-like protein, putative 0.0338 0.2921 0.9261
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0089 0.0089
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0338 0.2921 0.2921
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0089 0.0284
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.0726
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.2303
Echinococcus multilocularis neuronal calcium sensor 0.0041 0.016 0.0071
Schistosoma mansoni calpain-7 (C02 family) 0.0338 0.2921 0.2857
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.0726
Schistosoma mansoni rab 0.0041 0.016 0.0071
Entamoeba histolytica hypothetical protein 0.0035 0.011 0.011
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0338 0.2921 0.2921
Entamoeba histolytica calpain large subunit domain III containing protein 0.0237 0.1978 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0033 0.0089 0.0089
Brugia malayi fibroinase precursor 0.0033 0.0089 0.0089
Trypanosoma brucei Calpain-like protein CALP1.3 0.0102 0.0726 0.2303
Schistosoma mansoni calmodulin 0.0041 0.016 0.0071
Brugia malayi hypothetical protein 0.0035 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0033 0.0089 0.0089
Leishmania major centrin, putative 0.0041 0.016 0.0506
Loa Loa (eye worm) hypothetical protein 0.0033 0.0089 0.0089
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0221 0.0428
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0033 0.0089 0.0089
Echinococcus multilocularis calpain A 0.0938 0.848 0.8466
Giardia lamblia Cathepsin B precursor 0.0364 0.3155 1
Echinococcus granulosus calumenin 0.0041 0.016 0.0071
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0102 0.0726 0.2303
Echinococcus granulosus calbindin 32 0.0041 0.016 0.0071
Trypanosoma brucei calpain-like protein, putative 0.0338 0.2921 0.9261
Loa Loa (eye worm) hypothetical protein 0.0033 0.0089 0.0089
Echinococcus multilocularis calpain family protein 1, d 0.066 0.5908 0.5871
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0338 0.2921 0.2921
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.0726
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0.0089 0.0089
Trypanosoma brucei calpain, putative 0.0102 0.0726 0.2303
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0221 0.2059
Echinococcus multilocularis EF hand domain containing family member A2 0.0041 0.016 0.0071
Brugia malayi Cathepsin L-like precursor 0.0033 0.0089 0.0089
Trypanosoma brucei caltractin, putative 0.0041 0.016 0.0506
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0364 0.3155 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0089 0.0284
Trichomonas vaginalis myosin light chain 1, putative 0.0041 0.016 0.0229
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.2303
Onchocerca volvulus 0.0559 0.4964 1
Entamoeba histolytica calcium-binding protein, putative 0.0041 0.016 0.0372
Echinococcus granulosus neuronal calcium sensor 0.0041 0.016 0.0071
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1406 0.1406
Echinococcus granulosus EF hand domain containing family member A2 0.0041 0.016 0.0071
Loa Loa (eye worm) cysteine protease 0.0033 0.0089 0.0089
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0199 0.011
Entamoeba histolytica calmodulin, putative 0.0041 0.016 0.0372
Entamoeba histolytica hypothetical protein 0.0035 0.011 0.011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0089 0.0284
Echinococcus multilocularis programmed cell death protein 0.0041 0.016 0.0071
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0338 0.2921 0.9261
Leishmania major calmodulin, putative 0.0041 0.016 0.0506
Schistosoma mansoni hypothetical protein 0.0102 0.0726 0.0643
Trypanosoma brucei calpain, putative 0.0102 0.0726 0.2303
Schistosoma mansoni Mername-AA248 (C02 family) 0.0338 0.2921 0.2857
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0102 0.0726 0.2078
Echinococcus granulosus EF HAND 1 calcium binding site 0.0041 0.016 0.0071
Trypanosoma cruzi calmodulin, putative 0.0041 0.016 0.016
Brugia malayi calpain 5 0.0237 0.1978 0.1978
Echinococcus granulosus calmodulin 0.0041 0.016 0.0071
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0102 0.0726 0.2078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0199 0.011
Giardia lamblia Cathepsin B precursor 0.0364 0.3155 1
Leishmania major cathepsin L-like protease 0.0033 0.0089 0.0284
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.2303
Loa Loa (eye worm) EF hand family protein 0.0041 0.016 0.016
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0089 0.0089
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0041 0.016 0.0248
Trypanosoma brucei protein I/6 0.0041 0.016 0.0506
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0221 0.0694
Loa Loa (eye worm) acetyltransferase 0.0175 0.1406 0.1406
Trypanosoma cruzi kinesin, putative 0.0237 0.1978 0.1978
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.2303
Schistosoma mansoni mitochondrial solute carrier 0.0041 0.016 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0199 0.011
Schistosoma mansoni hypothetical protein 0.0166 0.1324 0.1246
Toxoplasma gondii hypothetical protein 0.0102 0.0726 0.2078
Brugia malayi cathepsin L-like cysteine proteinase 0.0033 0.0089 0.0089
Trichomonas vaginalis calpain, putative 0.0102 0.0726 0.2078
Leishmania major hypothetical protein, unknown function 0.0102 0.0726 0.2303
Leishmania major protein kinase, putative 0.0041 0.016 0.0506
Schistosoma mansoni calpain C (C02 family) 0.0338 0.2921 0.2857
Schistosoma mansoni neuronal calcium sensor 0.0041 0.016 0.0071
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0102 0.0726 0.0726
Entamoeba histolytica protein kinase, putative 0.0237 0.1978 1
Trichomonas vaginalis hypothetical protein 0.0102 0.0726 0.2078
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.016 0.0506
Trypanosoma brucei calpain-like protein, putative 0.0338 0.2921 0.9261
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0089 0.0089
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0102 0.0726 0.0726
Echinococcus multilocularis calpain 7 (C02 family) 0.0338 0.2921 0.2857
Loa Loa (eye worm) calpain D 0.0102 0.0726 0.0726
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.026 0.0558
Trypanosoma cruzi caltractin, putative 0.0041 0.016 0.016
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.2303
Brugia malayi Cathepsin L-like precursor 0.0033 0.0089 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0089 0.0284
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0041 0.016 0.0071
Trypanosoma brucei calmodulin, putative 0.0041 0.016 0.0506
Trichomonas vaginalis calmodulin-2, putative 0.0041 0.016 0.0229
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.2303
Echinococcus multilocularis neurocalcin 0.0041 0.016 0.0071
Loa Loa (eye worm) hypothetical protein 0.0033 0.0089 0.0089
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0726 0.2303
Leishmania major cathepsin L-like protease 0.0033 0.0089 0.0284
Brugia malayi Cathepsin L-like precursor 0.0033 0.0089 0.0089
Schistosoma mansoni hypothetical protein 0.0166 0.1324 0.1246
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0199 0.011
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0089 0.0089
Echinococcus granulosus calpain A 0.0938 0.848 0.8466
Trichomonas vaginalis calmodulin, putative 0.0041 0.016 0.0229
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0089 0.0089
Trypanosoma brucei I/6 autoantigen 0.0041 0.016 0.0506
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.011 0.0021
Echinococcus multilocularis calbindin 32 0.0041 0.016 0.0071
Echinococcus multilocularis geminin 0.0166 0.1324 0.1246
Loa Loa (eye worm) ctsf protein 0.0033 0.0089 0.0089
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0089 0.0089
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0102 0.0726 0.0726
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0041 0.016 0.016
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0041 0.016 0.016
Loa Loa (eye worm) calpain 5 0.0237 0.1978 0.1978
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0041 0.016 0.0506
Schistosoma mansoni hypothetical protein 0.0041 0.016 0.0071
Trypanosoma cruzi I/6 autoantigen, putative 0.0041 0.016 0.016
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0102 0.0726 0.0726
Trichomonas vaginalis calmodulin, putative 0.0041 0.016 0.0229
Trypanosoma brucei cysteine peptidase, putative 0.0102 0.0726 0.2303
Loa Loa (eye worm) cathepsin B 0.0364 0.3155 0.3155
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0041 0.016 0.0229
Leishmania major cathepsin L-like protease 0.0033 0.0089 0.0284
Echinococcus multilocularis calpain 0.0338 0.2921 0.2857
Giardia lamblia Cathepsin B precursor 0.0364 0.3155 1
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0089 0.0089
Schistosoma mansoni calpain (C02 family) 0.0338 0.2921 0.2857
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0199 0.011
Trichomonas vaginalis centrin, putative 0.0041 0.016 0.0229
Leishmania major calcineurin B subunit, putative 0.0041 0.016 0.0506
Trypanosoma brucei centrin, putative 0.0041 0.016 0.0506
Onchocerca volvulus 0.0041 0.016 0.0144
Echinococcus multilocularis calumenin 0.0041 0.016 0.0071
Echinococcus granulosus programmed cell death protein 0.0041 0.016 0.0071
Trichomonas vaginalis calcium binding proteins, putative 0.0041 0.016 0.0229
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0938 0.848 0.8466
Trypanosoma cruzi centrin, putative 0.0041 0.016 0.016
Brugia malayi EF hand family protein 0.0041 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0296 0.2532 0.2532

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.548133892 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 11.22018454 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 14.12537545 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 0.0657 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.5623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.