TDR Targets

Basic information

Technical information

TDR Targets ID: 1406931
Name: 1-(2,4-difluorophenyl)-2,6-dimethylpyridin-4- one
MW: 235.229 | Formula: C13H11F2NO
H donors: 0 H acceptors: 1 LogP: 2.78 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(c(c1)F)n1c(C)cc(=O)cc1C
InChi: 1S/C13H11F2NO/c1-8-5-11(17)6-9(2)16(8)13-4-3-10(14)7-12(13)15/h3-7H,1-2H3
InChiKey: UVEOQBGKTXDWLL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(2,4-difluorophenyl)-2,6-dimethyl-pyridin-4-one
1-(2,4-difluorophenyl)-2,6-dimethyl-4-pyridinone
1-(2,4-difluorophenyl)-2,6-dimethyl-4-pyridone
ZINC03180208
Oprea1_064161
Enamine_000856
MLS001003750
SMR000347589
T0503-0537

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	muscleblind-like splicing regulator 1	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	muscleblind protein 1	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	Muscleblind-like protein	Get druggable targets OG5_132352	All targets in OG5_132352
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.0627
Echinococcus multilocularis	programmed cell death protein	0.0114	0.0288	0.0288
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0094	0.0224	0.0224
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0114	0.0288	0.0346
Loa Loa (eye worm)	cysteine protease	0.0094	0.0224	0.022
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0224	0.022
Brugia malayi	calpain family protein 1	0.2508	0.7994	0.7973
Echinococcus multilocularis	neurocalcin	0.0114	0.0288	0.0288
Trypanosoma brucei	calpain-like protein, putative	0.0946	0.2967	0.9071
Brugia malayi	Muscleblind-like protein	0.018	0.0503	0.0407
Brugia malayi	programmed cell death protein 6	0.0114	0.0288	0.019
Trypanosoma brucei	Component of motile flagella 41	0.0114	0.0288	0.0209
Echinococcus granulosus	cathepsin l1	0.0094	0.0224	0.0224
Echinococcus granulosus	cysteine protease	0.0094	0.0224	0.0224
Brugia malayi	Cathepsin L-like precursor	0.0094	0.0224	0.0126
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0946	0.2967	0.2805
Trypanosoma brucei	protein I/6	0.0114	0.0288	0.0209
Trypanosoma brucei	calpain-like protein, putative	0.0946	0.2967	0.9071
Leishmania major	hypothetical protein, conserved	0.0114	0.0288	0.0209
Trichomonas vaginalis	hypothetical protein	0.0284	0.0837	0.2028
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0313	0.093	0.0926
Schistosoma mansoni	centrin-related	0.0114	0.0288	0.0288
Toxoplasma gondii	calmodulin CAM1	0.0114	0.0288	0.0209
Loa Loa (eye worm)	fibroinase	0.0094	0.0224	0.022
Plasmodium falciparum	calpain	0.0284	0.0837	1
Echinococcus granulosus	calpain 5	0.0946	0.2967	0.2967
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0224	0.022
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0094	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0224	0.022
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.0627
Schistosoma mansoni	hypothetical protein	0.0284	0.0837	0.0837
Schistosoma mansoni	cell adhesion molecule	0.0026	0.0004	0.0004
Trypanosoma brucei	cytoskeleton-associated protein CAP5.5, putative	0.0284	0.0837	0.2028
Brugia malayi	EF hand family protein	0.0114	0.0288	0.019
Toxoplasma gondii	centrin, putative	0.0114	0.0288	0.0209
Schistosoma mansoni	calmodulin	0.0114	0.0288	0.0288
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0094	0.0224	0.0126
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.2028
Schistosoma mansoni	calmodulin related calcium binding protein	0.0114	0.0288	0.0288
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.2028
Echinococcus granulosus	calumenin	0.0114	0.0288	0.0288
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.01	0.01
Schistosoma mansoni	neuronal calcium sensor	0.0114	0.0288	0.0288
Schistosoma mansoni	calpain-2 (C02 family)	0.0284	0.0837	0.0837
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.01	0.0096
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0284	0.0837	0.0627
Entamoeba histolytica	grainin, putative	0.0114	0.0288	0.0346
Trypanosoma brucei	Present in the outer mitochondrial membrane proteome 33	0.0114	0.0288	0.0209
Leishmania major	cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.2028
Entamoeba histolytica	calmodulin, putative	0.0114	0.0288	0.0346
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.2028
Loa Loa (eye worm)	hypothetical protein	0.2223	0.7078	0.7077
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0288	0.0283
Trypanosoma brucei	CAMK/CAMKL family protein kinase, putative	0.0114	0.0288	0.0209
Trypanosoma brucei	cysteine peptidase, putative	0.0284	0.0837	0.2028
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0946	0.2967	0.2805
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.2028
Brugia malayi	EF hand family protein	0.0114	0.0288	0.019
Trichomonas vaginalis	calcineurin B subunit, putative	0.0114	0.0288	0.0209
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0284	0.0837	0.0627
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0094	0.0224	0.0224
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.2621	0.8359	0.8359
Leishmania major	kinesin, putative	0.0662	0.2052	0.6043
Echinococcus granulosus	EF hand domain containing family member A2	0.0114	0.0288	0.0288
Schistosoma mansoni	calpain (C02 family)	0.0946	0.2967	0.2967
Loa Loa (eye worm)	programmed cell death protein 6	0.0114	0.0288	0.0283
Leishmania major	hypothetical protein, unknown function	0.0284	0.0837	0.2028
Echinococcus granulosus	sarcoplasmic calcium binding protein	0.0114	0.0288	0.0288
Trichomonas vaginalis	calcium binding protein, putative	0.0114	0.0288	0.0209
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0946	0.2967	0.9071
Loa Loa (eye worm)	hypothetical protein	0.003	0.002	0.0016
Loa Loa (eye worm)	calpain	0.0946	0.2967	0.2964
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0284	0.0837	0.2028
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1033	0.3248	0.3093
Trichomonas vaginalis	conserved hypothetical protein	0.0284	0.0837	0.2028
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0288	0.0209
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.0627
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0946	0.2967	0.2805
Trypanosoma cruzi	conserved protein	0.0284	0.0837	0.0627
Trypanosoma brucei	Calpain-like protein CALP1.3	0.0284	0.0837	0.2028
Brugia malayi	Papain family cysteine protease containing protein	0.0094	0.0224	0.0126
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.0288	0.0209
Schistosoma mansoni	mitochondrial solute carrier	0.0114	0.0288	0.0288
Trypanosoma cruzi	centrin, putative	0.0114	0.0288	0.0065
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0094	0.0224	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0224	0.022
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0284	0.0837	0.0627
Loa Loa (eye worm)	hypothetical protein	0.2508	0.7994	0.7993
Loa Loa (eye worm)	calpain family protein 1	0.1846	0.5864	0.5862
Echinococcus multilocularis	programmed cell death protein	0.0114	0.0288	0.0288
Trichomonas vaginalis	calpain, putative	0.0284	0.0837	0.2028
Echinococcus multilocularis	EF hand domain containing family member A2	0.0114	0.0288	0.0288
Entamoeba histolytica	hypothetical protein, conserved	0.0114	0.0288	0.0346
Trypanosoma cruzi	kinesin, putative	0.0662	0.2052	0.1869
Echinococcus granulosus	muscleblind protein	0.018	0.0503	0.0503
Brugia malayi	calpain 5	0.0662	0.2052	0.1971
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0114	0.0288	0.0065
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.2028
Leishmania major	phospholipase c-like protein	0.0114	0.0288	0.0209
Onchocerca volvulus		0.0114	0.0288	0.0134
Brugia malayi	calpain family protein 1	0.2508	0.7994	0.7973
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0946	0.2967	0.2805
Echinococcus multilocularis	cathepsin L	0.0094	0.0224	0.0224
Toxoplasma gondii	EFHC1, putative	0.0114	0.0288	0.0209
Trypanosoma cruzi	caltractin, putative	0.0114	0.0288	0.0065
Echinococcus granulosus	cathepsin L	0.0094	0.0224	0.0224
Schistosoma mansoni	cathepsin F (C01 family)	0.0094	0.0224	0.0224
Toxoplasma gondii	EF hand domain-containing protein	0.0114	0.0288	0.0209
Trichomonas vaginalis	Crustacean calcium-binding protein, putative	0.0114	0.0288	0.0209
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0094	0.0224	0.0224
Echinococcus multilocularis	calcium uptake protein 1	0.0114	0.0288	0.0288
Echinococcus granulosus	calpain A	0.2621	0.8359	0.8359
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0094	0.0224	0.0224
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.2508	0.7994	0.7994
Trypanosoma brucei	antigen, putative	0.0946	0.2967	0.9071
Schistosoma mansoni	hypothetical protein	0.0114	0.0288	0.0288
Echinococcus granulosus	EF HAND 1 calcium binding site	0.0114	0.0288	0.0288
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0946	0.2967	0.2805
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0094	0.0224	0.0224
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0946	0.2967	0.9071
Leishmania major	calmodulin-like protein	0.0114	0.0288	0.0209
Leishmania major	centrin, putative	0.0114	0.0288	0.0209
Echinococcus granulosus	calmodulin	0.0114	0.0288	0.0288
Trypanosoma brucei	calpain-like protein, putative	0.0946	0.2967	0.9071
Echinococcus granulosus	EF hand domain containing family member A2	0.0114	0.0288	0.0288
Echinococcus granulosus	neuronal calcium sensor	0.0114	0.0288	0.0288
Schistosoma mansoni	neuronal calcium sensor	0.0114	0.0288	0.0288
Schistosoma mansoni	centrin	0.0114	0.0288	0.0288
Brugia malayi	Papain family cysteine protease containing protein	0.0094	0.0224	0.0126
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0114	0.0288	0.0065
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0284	0.0837	0.2028
Plasmodium vivax	calpain, putative	0.0946	0.2967	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1033	0.3248	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0094	0.0224	0.022
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0224	0.022
Toxoplasma gondii	calpain family cysteine protease domain-containing protein	0.0284	0.0837	0.2028
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0284	0.0837	0.0627
Loa Loa (eye worm)	calpain family protein 1	0.2508	0.7994	0.7993
Echinococcus granulosus	centrin 2	0.0114	0.0288	0.0288
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0094	0.0224	0.0224
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0946	0.2967	0.2967
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0284	0.0837	0.0627
Leishmania major	protein kinase, putative	0.0114	0.0288	0.0209
Giardia lamblia	Cathepsin B precursor	0.1033	0.3248	1
Echinococcus multilocularis	calpain 7 (C02 family)	0.0946	0.2967	0.2967
Trypanosoma brucei	mitochondrial calcium uptake 1	0.0114	0.0288	0.0209
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.1033	0.3248	1
Schistosoma mansoni	ef hand domain family member A2	0.0114	0.0288	0.0288
Leishmania major	centrin, putative,caltractin, putative	0.0114	0.0288	0.0209
Trichomonas vaginalis	calcium binding protein, putative	0.0114	0.0288	0.0209
Onchocerca volvulus		0.0114	0.0288	0.0134
Brugia malayi	Cathepsin L-like precursor	0.0094	0.0224	0.0126
Echinococcus granulosus	calpain 7 C02 family	0.0946	0.2967	0.2967
Toxoplasma gondii	centrin	0.0114	0.0288	0.0209
Loa Loa (eye worm)	calmodulin-like protein	0.0114	0.0288	0.0283
Schistosoma mansoni	cathepsin B (C01 family)	0.0094	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0224	0.022
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0224	0.022
Brugia malayi	calpain D	0.0284	0.0837	0.0745
Onchocerca volvulus	Tyrosine kinase homolog	0.0293	0.0864	0.1353
Trypanosoma brucei	calmodulin, putative	0.0114	0.0288	0.0209
Trypanosoma cruzi	centrin, putative	0.0114	0.0288	0.0065
Trichomonas vaginalis	centrin, putative	0.0114	0.0288	0.0209
Echinococcus multilocularis	cathepsin L cysteine protease	0.0094	0.0224	0.0224
Echinococcus multilocularis	EF hand domain containing family member A2	0.0114	0.0288	0.0288
Loa Loa (eye worm)	hypothetical protein	0.1846	0.5864	0.5862
Trypanosoma brucei	glucosamine 6-phosphate n-acetyltransferase	0.0284	0.0837	0.2028
Trypanosoma brucei	hypothetical protein	0.0284	0.0837	0.2028
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0094	0.0224	0.0126
Trichomonas vaginalis	calmodulin, putative	0.0114	0.0288	0.0209
Schistosoma mansoni	rab	0.0114	0.0288	0.0288
Trypanosoma brucei	Calpain-like protein 1.2	0.0284	0.0837	0.2028
Schistosoma mansoni	cathepsin F (C01 family)	0.0094	0.0224	0.0224
Trypanosoma brucei	Calpain-like protein 2	0.0284	0.0837	0.2028
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.2621	0.8359	0.8359
Loa Loa (eye worm)	EF hand family protein	0.0114	0.0288	0.0283
Brugia malayi	calpain 5	0.0284	0.0837	0.0745
Trypanosoma cruzi	calmodulin, putative	0.0114	0.0288	0.0065
Trypanosoma cruzi	mitochondrial calcium uptake 1, putative	0.0114	0.0288	0.0065
Trypanosoma cruzi	centrin-3	0.0114	0.0288	0.0065
Trichomonas vaginalis	calcineurin B subunit, putative	0.0114	0.0288	0.0209
Giardia lamblia	Hypothetical protein	0.0114	0.0288	0.0209
Trichomonas vaginalis	calpain, putative	0.0284	0.0837	0.2028
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0224	0.022
Echinococcus granulosus	cathepsin l1	0.0094	0.0224	0.0224
Brugia malayi	Papain family cysteine protease containing protein	0.0094	0.0224	0.0126
Trypanosoma brucei	hypothetical protein, conserved	0.0114	0.0288	0.0209
Brugia malayi	cathepsin L precursor	0.0094	0.0224	0.0126
Schistosoma mansoni	reticulocalbin	0.0114	0.0288	0.0288
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.2028
Entamoeba histolytica	calcium-binding protein, putative	0.0114	0.0288	0.0346
Trichomonas vaginalis	calmodulin-2, putative	0.0114	0.0288	0.0209
Trichomonas vaginalis	calmodulin, putative	0.0114	0.0288	0.0209
Trypanosoma cruzi	I/6 autoantigen, putative	0.0114	0.0288	0.0065
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.01	0.01
Brugia malayi	Calmodulin-like protein	0.0114	0.0288	0.019
Trypanosoma brucei	calpain-like protein, putative	0.0946	0.2967	0.9071
Echinococcus granulosus	calpain	0.0946	0.2967	0.2967
Trichomonas vaginalis	calpain, putative	0.0284	0.0837	0.2028
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0026	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.018	0.0503	0.0499
Trichomonas vaginalis	calmodulin, putative	0.0114	0.0288	0.0209
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.2028
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.01	0.01
Leishmania major	calmodulin-like protein	0.0114	0.0288	0.0209
Entamoeba histolytica	calmodulin, putative	0.0114	0.0288	0.0346
Trypanosoma brucei	calpain, putative	0.0284	0.0837	0.2028
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.2028
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0224	0.022
Schistosoma mansoni	calpain-7 (C02 family)	0.0946	0.2967	0.2967
Schistosoma mansoni	neuronal calcium sensor	0.0114	0.0288	0.0288
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.0627
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.0627
Schistosoma mansoni	reticulocalbin	0.0114	0.0288	0.0288
Entamoeba histolytica	protein kinase, putative	0.0662	0.2052	1
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0284	0.0837	0.2028
Echinococcus multilocularis	cathepsin L	0.0094	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0284	0.0837	0.0833
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1033	0.3248	1
Loa Loa (eye worm)	calpain 5	0.0662	0.2052	0.2048
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.2028
Trichomonas vaginalis	calmodulin, putative	0.0114	0.0288	0.0209
Echinococcus multilocularis	calmodulin	0.0114	0.0288	0.0288
Trichomonas vaginalis	myosin light chain 1, putative	0.0114	0.0288	0.0209
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.01	0.01
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0284	0.0837	0.0627
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0094	0.0224	0.0224
Leishmania major	programmed cell death 6 protein-like protein	0.0114	0.0288	0.0209
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0284	0.0837	0.2028
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0094	0.0224	0.022
Trypanosoma brucei	caltractin, putative	0.0114	0.0288	0.0209
Leishmania major	hypothetical protein, conserved	0.0284	0.0837	0.2028
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0094	0.0224	0.0126
Trypanosoma cruzi	kinesin, putative	0.0662	0.2052	0.1869
Plasmodium vivax	hypothetical protein, conserved	0.0114	0.0288	0.023
Brugia malayi	Papain family cysteine protease containing protein	0.0094	0.0224	0.0126
Echinococcus multilocularis	calpain	0.0946	0.2967	0.2967
Leishmania major	calpain family cysteine protease-like protein	0.0284	0.0837	0.2028
Trypanosoma cruzi	calmodulin, putative	0.0114	0.0288	0.0065
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0284	0.0837	0.0627
Trichomonas vaginalis	calmodulin, putative	0.0114	0.0288	0.0209
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0284	0.0837	0.2028
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0946	0.2967	0.9071
Toxoplasma gondii	calcium-dependent protein kinase	0.0114	0.0288	0.0209
Echinococcus granulosus	programmed cell death protein	0.0114	0.0288	0.0288
Trypanosoma brucei	calmodulin, putative	0.0114	0.0288	0.0209
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0946	0.2967	0.2805
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0094	0.0224	0.0224
Echinococcus multilocularis	EF HAND 1, calcium binding site	0.0114	0.0288	0.0288
Brugia malayi	cathepsin L-like cysteine proteinase	0.0094	0.0224	0.0126
Entamoeba histolytica	calcium binding family protein	0.0114	0.0288	0.0346
Trypanosoma brucei	centrin, putative	0.0114	0.0288	0.0209
Leishmania major	calcineurin B subunit, putative	0.0114	0.0288	0.0209
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0662	0.2052	1
Echinococcus multilocularis	calpain A	0.2621	0.8359	0.8359
Toxoplasma gondii	troponin c, isotype gamma, putative	0.0114	0.0288	0.0209
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0114	0.0288	0.0065
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0284	0.0837	0.0627
Loa Loa (eye worm)	cathepsin B	0.1033	0.3248	0.3245
Entamoeba histolytica	grainin 2	0.0114	0.0288	0.0346
Brugia malayi	cathepsin F-like cysteine proteinase	0.0094	0.0224	0.0126
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0946	0.2967	0.2805
Giardia lamblia	Cathepsin B precursor	0.1033	0.3248	1
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0284	0.0837	0.2028
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0094	0.0224	0.0224
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0094	0.0224	0.0224
Echinococcus multilocularis	muscleblind protein 1	0.018	0.0503	0.0503
Brugia malayi	calcium-binding protein	0.0114	0.0288	0.019
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0313	0.093	0.0839
Echinococcus granulosus	calcium uptake protein 1	0.0114	0.0288	0.0288
Schistosoma mansoni	neuronal calcium sensor	0.0114	0.0288	0.0288
Trypanosoma brucei	centrin-3	0.0114	0.0288	0.0209
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.2028
Leishmania major	centrin, putative	0.0114	0.0288	0.0209
Brugia malayi	Cathepsin L-like precursor	0.0094	0.0224	0.0126
Echinococcus multilocularis	cathepsin L cysteine protease	0.0094	0.0224	0.0224
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.2028
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0114	0.0288	0.0065
Echinococcus multilocularis	cysteine protease	0.0094	0.0224	0.0224
Schistosoma mansoni	cathepsin F (C01 family)	0.0094	0.0224	0.0224
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.0627
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.2028
Trichomonas vaginalis	calmodulin, putative	0.0114	0.0288	0.0209
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0094	0.0224	0.0224
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0094	0.0224	0.0224
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.01	0.01
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.2621	0.8359	0.8359
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0114	0.0288	0.023
Echinococcus granulosus	roundabout 2	0.003	0.002	0.002
Trichomonas vaginalis	calcium binding protein, putative	0.0114	0.0288	0.0209
Brugia malayi	Cathepsin L-like precursor	0.0094	0.0224	0.0126
Plasmodium vivax	centrin-1, putative	0.0114	0.0288	0.023
Schistosoma mansoni	calmodulin	0.0114	0.0288	0.0288
Brugia malayi	Cathepsin L-like precursor	0.0094	0.0224	0.0126
Leishmania major	hypothetical protein, conserved	0.0114	0.0288	0.0209
Loa Loa (eye worm)	hypothetical protein	0.003	0.002	0.0016
Echinococcus granulosus	cathepsin L cysteine protease	0.0094	0.0224	0.0224
Schistosoma mansoni	hypothetical protein	0.0114	0.0288	0.0288
Entamoeba histolytica	calpain family cysteine protease, putative	0.0284	0.0837	0.3355
Echinococcus granulosus	calbindin 32	0.0114	0.0288	0.0288
Trichomonas vaginalis	centrin, putative	0.0114	0.0288	0.0209
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0094	0.0224	0.022
Brugia malayi	fibroinase precursor	0.0094	0.0224	0.0126
Echinococcus multilocularis	cysteine protease	0.0094	0.0224	0.0224
Echinococcus granulosus	calpain A	0.0946	0.2967	0.2967
Toxoplasma gondii	hypothetical protein	0.0284	0.0837	0.2028
Trypanosoma cruzi	calmodulin, putative	0.0114	0.0288	0.0065
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0284	0.0837	0.0627
Onchocerca volvulus		0.0114	0.0288	0.0134
Leishmania major	calpain protease-like protein	0.0284	0.0837	0.2028
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0946	0.2967	0.9071
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.2028
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.2028
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0946	0.2967	0.9071
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0114	0.0288	0.0346
Trichomonas vaginalis	calcium binding protein, putative	0.0114	0.0288	0.0209
Echinococcus multilocularis	muscleblind protein	0.018	0.0503	0.0503
Echinococcus granulosus	cathepsin L	0.0094	0.0224	0.0224
Echinococcus multilocularis	centrin 2	0.0114	0.0288	0.0288
Leishmania major	i/6 autoantigen-like protein	0.0114	0.0288	0.0209
Echinococcus multilocularis	roundabout 2	0.003	0.002	0.002
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.2028
Brugia malayi	calpain 7	0.0946	0.2967	0.2896
Trypanosoma cruzi	programmed cell death 6 protein-like, putative	0.0114	0.0288	0.0065
Echinococcus multilocularis	calpain 5	0.0946	0.2967	0.2967
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0094	0.0224	0.022
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0284	0.0837	0.0627
Schistosoma mansoni	cathepsin C	0.0094	0.0224	0.0224
Trypanosoma cruzi	I/6 autoantigen, putative	0.0114	0.0288	0.0065
Trichomonas vaginalis	calmodulin, putative	0.0114	0.0288	0.0209
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0946	0.2967	0.2805
Trypanosoma brucei	calpain, putative	0.0284	0.0837	0.2028
Echinococcus multilocularis	sarcoplasmic calcium binding protein	0.0114	0.0288	0.0288
Leishmania major	calmodulin, putative	0.0114	0.0288	0.0209
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1033	0.3248	0.3248
Loa Loa (eye worm)	hypothetical protein	0.1562	0.4949	0.4947
Schistosoma mansoni	calcium binding atopy-related autoantigen	0.0114	0.0288	0.0288
Trypanosoma brucei	Calpain-like protein 1.1	0.0284	0.0837	0.2028
Trichomonas vaginalis	calcium binding proteins, putative	0.0114	0.0288	0.0209
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.01	0.01
Schistosoma mansoni	cathepsin S (C01 family)	0.0094	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0224	0.022
Echinococcus multilocularis	neuronal calcium sensor	0.0114	0.0288	0.0288
Plasmodium falciparum	centrin-1	0.0114	0.0288	0.1031
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0094	0.0224	0.022
Onchocerca volvulus		0.1562	0.4949	1
Trypanosoma brucei	centrin, putative	0.0114	0.0288	0.0209
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.2028
Onchocerca volvulus		0.0286	0.0842	0.1308
Trichomonas vaginalis	calmodulin, putative	0.0114	0.0288	0.0209
Trichomonas vaginalis	calmodulin, putative	0.0114	0.0288	0.0209
Echinococcus multilocularis	calumenin	0.0114	0.0288	0.0288
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0094	0.0224	0.0224
Echinococcus multilocularis	calbindin 32	0.0114	0.0288	0.0288
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.0627
Brugia malayi	Cathepsin L-like precursor	0.0094	0.0224	0.0126
Echinococcus multilocularis	hypothetical protein	0.0946	0.2967	0.2967
Leishmania major	calmodulin, putative	0.0114	0.0288	0.0209
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0946	0.2967	0.2805
Loa Loa (eye worm)	calpain D	0.0284	0.0837	0.0833
Echinococcus multilocularis	calpain family protein 1, d	0.1846	0.5864	0.5864
Leishmania major	calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.2028
Loa Loa (eye worm)	ctsf protein	0.0094	0.0224	0.022
Giardia lamblia	Cathepsin B precursor	0.1033	0.3248	1
Trypanosoma brucei	I/6 autoantigen	0.0114	0.0288	0.0209
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.01	0.01
Trichomonas vaginalis	DNA-dependent protein kinase catalytic subunit-interacting protein, putative	0.0114	0.0288	0.0209
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0094	0.0224	0.0224
Schistosoma mansoni	Sarcoplasmic calcium-binding protein (SCP).	0.0114	0.0288	0.0288
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.2621	0.8359	0.8359
Toxoplasma gondii	cathepsin B	0.1033	0.3248	1
Brugia malayi	Cathepsin L-like precursor	0.0094	0.0224	0.0126
Echinococcus multilocularis	calmodulin	0.0114	0.0288	0.0288
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0946	0.2967	0.2805
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0284	0.0837	0.2028
Brugia malayi	Papain family cysteine protease containing protein	0.0094	0.0224	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0288	0.0283
Schistosoma mansoni	calpain-7 (C02 family)	0.0946	0.2967	0.2967
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.0627
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0094	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.018	0.0503	0.0499
Echinococcus granulosus	neurocalcin	0.0114	0.0288	0.0288
Brugia malayi	Papain family cysteine protease containing protein	0.0094	0.0224	0.0126
Brugia malayi	cathepsin L-like precursor	0.0094	0.0224	0.0126
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0284	0.0837	0.2028
Brugia malayi	Cathepsin L-like precursor	0.0094	0.0224	0.0126
Trypanosoma brucei	kinesin, putative	0.0662	0.2052	0.6043
Schistosoma mansoni	calpain C (C02 family)	0.0946	0.2967	0.2967

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (binding)	3.5481 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.9433 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1544527

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1406931