TDR Targets

Basic information

Technical information

TDR Targets ID: 1406941
Name: N-[2-[(3-acetylphenyl)-[2-(cyclopentylamino)- 2-oxo-1-pyridin-4-ylethyl]amino]-2-oxoethyl]f uran-2-carboxamide
MW: 488.535 | Formula: C27H28N4O5
H donors: 2 H acceptors: 5 LogP: 2.61 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C(N(c1cccc(c1)C(=O)C)C(=O)CNC(=O)c1ccco1)c1ccncc1)NC1CCCC1
InChi: 1S/C27H28N4O5/c1-18(32)20-6-4-9-22(16-20)31(24(33)17-29-26(34)23-10-5-15-36-23)25(19-11-13-28-14-12-19)27(35)30-21-7-2-3-8-21/h4-6,9-16,21,25H,2-3,7-8,17H2,1H3,(H,29,34)(H,30,35)
InChiKey: PRZFZQMWKURXAX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-[(3-acetylphenyl)-[2-(cyclopentylamino)-2-oxo-1-(4-pyridyl)ethyl]amino]-2-oxo-ethyl]furan-2-carboxamide
N-[2-[(3-acetylphenyl)-[2-(cyclopentylamino)-2-oxo-1-(4-pyridyl)ethyl]amino]-2-oxoethyl]-2-furancarboxamide
N-[2-[(3-acetylphenyl)-[2-(cyclopentylamino)-2-keto-1-(4-pyridyl)ethyl]amino]-2-keto-ethyl]-2-furamide
N-[2-[[2-(cyclopentylamino)-2-oxo-1-pyridin-4-yl-ethyl]-(3-ethanoylphenyl)amino]-2-oxo-ethyl]furan-2-carboxamide
ASN 05584576

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	karyopherin (importin) beta 1		No references
Homo sapiens	snurportin 1		No references
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	RAN, member RAS oncogene family		No references
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania infantum	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium hominis	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	ko:K07936 GTP-binding nuclear protein Ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Neospora caninum	GTP-binding nuclear protein Ran, related	Get druggable targets OG5_127514	All targets in OG5_127514
Entamoeba histolytica	Ran family GTPase	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Babesia bovis	GTP-binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium parvum	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania braziliensis	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma congolense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania donovani	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Theileria parva	GTP-binding nuclear protein ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Brugia malayi	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium yoelii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0044	0.0247	0.0139
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0482	0.3264	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0044	0.0247	0.0242
Trypanosoma brucei	Present in the outer mitochondrial membrane proteome 33	0.0075	0.0461	0.1077
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Toxoplasma gondii	cathepsin B	0.0482	0.3264	1
Echinococcus granulosus	calpain 7 C02 family	0.0418	0.2828	0.2824
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.2196
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.0399	0.0879
Schistosoma mansoni	ran	0.0026	0.0122	0.0117
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Loa Loa (eye worm)	cysteine protease	0.0044	0.0247	0.0228
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0418	0.2828	0.2739
Schistosoma mansoni	importin beta-1	0.0035	0.0186	0.0181
Giardia lamblia	Cathepsin L-like protease	0.0044	0.0247	0.0398
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.1109	0.7587	0.7586
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0126	0.0812	0.0698
Trypanosoma cruzi	major cysteine proteinase, putative	0.0044	0.0247	0.0127
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0418	0.2828	0.2739
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0247	0.0758
Schistosoma mansoni	calpain-2 (C02 family)	0.0126	0.0812	0.0808
Leishmania major	calmodulin-like protein	0.0075	0.0461	0.1077
Leishmania major	cathepsin L-like protease	0.0044	0.0247	0.0398
Echinococcus granulosus	cathepsin L	0.0044	0.0247	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0461	0.0442
Brugia malayi	cathepsin F-like cysteine proteinase	0.0044	0.0247	0.0229
Schistosoma mansoni	calpain (C02 family)	0.0418	0.2828	0.2824
Loa Loa (eye worm)	calmodulin-like protein	0.0075	0.0461	0.0442
Brugia malayi	EF hand family protein	0.0075	0.0461	0.0443
Trypanosoma brucei	calmodulin, putative	0.0075	0.0461	0.1077
Toxoplasma gondii	EFHC1, putative	0.0075	0.0461	0.1077
Echinococcus multilocularis	calpain	0.0418	0.2828	0.2824
Echinococcus multilocularis	neurocalcin	0.0075	0.0461	0.0456
Entamoeba histolytica	calcium binding family protein	0.0075	0.0461	0.184
Schistosoma mansoni	cpg binding protein	0.0037	0.0198	0.0193
Echinococcus granulosus	cathepsin L	0.0044	0.0247	0.0242
Leishmania major	calmodulin, putative	0.0075	0.0461	0.1077
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.014	0.043
Giardia lamblia	Cysteine protease	0.0044	0.0247	0.0398
Plasmodium vivax	unspecified product	0.0044	0.0247	0.0462
Entamoeba histolytica	hypothetical protein	0.0044	0.0247	0.068
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0044	0.0247	0.1813
Plasmodium vivax	vivapain-2	0.0044	0.0247	0.0462
Brugia malayi	Papain family cysteine protease containing protein	0.0044	0.0247	0.0229
Trichomonas vaginalis	calmodulin, putative	0.0075	0.0461	0.1412
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0044	0.0247	0.0758
Trypanosoma cruzi	calmodulin, putative	0.0075	0.0461	0.0343
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0044	0.0247	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0247	0.0228
Leishmania major	importin beta-1 subunit, putative	0.0028	0.014	0.0057
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0044	0.0247	0.0462
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0026	0.0122	0.0104
Echinococcus multilocularis	EF hand domain containing family member A2	0.0076	0.0473	0.0468
Echinococcus multilocularis	EF HAND 1, calcium binding site	0.0075	0.0461	0.0456
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.0698
Leishmania major	i/6 autoantigen-like protein	0.0075	0.0461	0.1077
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0044	0.0247	0.0242
Leishmania major	cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.2196
Schistosoma mansoni	calmodulin related calcium binding protein	0.0075	0.0461	0.0456
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0044	0.0247	0.0398
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.2196
Trichomonas vaginalis	conserved hypothetical protein	0.0126	0.0812	0.2489
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0247	0.0228
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0044	0.0247	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0816	0.5571	0.5562
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0044	0.0247	0.0758
Loa Loa (eye worm)	calpain D	0.0126	0.0812	0.0794
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0026	0.0122	0.0103
Echinococcus multilocularis	cpg binding protein	0.0037	0.0198	0.0193
Trichomonas vaginalis	calmodulin, putative	0.0075	0.0461	0.1412
Giardia lamblia	Cathepsin L precursor	0.0044	0.0247	0.0398
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0418	0.2828	0.8614
Schistosoma mansoni	cathepsin F (C01 family)	0.0044	0.0247	0.0242
Plasmodium falciparum	serine repeat antigen 4	0.0044	0.0247	0.1813
Trichomonas vaginalis	myosin light chain 1, putative	0.0075	0.0461	0.1412
Schistosoma mansoni	neuronal calcium sensor	0.0075	0.0461	0.0456
Entamoeba histolytica	cysteine proteinase 1, putative	0.0044	0.0247	0.068
Trypanosoma cruzi	cysteine protease, putative	0.0044	0.0247	0.0127
Leishmania major	hypothetical protein, conserved	0.0126	0.0812	0.2196
Plasmodium vivax	centrin-1, putative	0.0075	0.0461	0.1251
Echinococcus granulosus	centrin 2	0.0075	0.0461	0.0456
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0126	0.0812	0.0698
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0044	0.0247	0.0242
Onchocerca volvulus		0.0075	0.0461	0.0611
Giardia lamblia	Cathepsin B precursor	0.0044	0.0247	0.0398
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.2196
Echinococcus multilocularis	calcium uptake protein 1	0.0076	0.0473	0.0468
Schistosoma mansoni	ran	0.0026	0.0122	0.0117
Loa Loa (eye worm)	EF hand family protein	0.0075	0.0461	0.0442
Plasmodium falciparum	serine repeat antigen 7	0.0044	0.0247	0.1813
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Echinococcus multilocularis	neuronal calcium sensor	0.0075	0.0461	0.0456
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Schistosoma mansoni	cpg binding protein	0.0035	0.0185	0.018
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.2196
Onchocerca volvulus		0.0044	0.0247	0.0139
Giardia lamblia	Cysteine protease	0.0044	0.0247	0.0398
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0247	0.0127
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0247	0.0127
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0044	0.0247	0.0462
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0044	0.0247	0.0758
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.2196
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0247	0.0758
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0247	0.0398
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.0247	0.068
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0247	0.0229
Brugia malayi	Papain family cysteine protease containing protein	0.0044	0.0247	0.0229
Plasmodium falciparum	serine repeat antigen 1	0.0044	0.0247	0.1813
Trypanosoma cruzi	caltractin, putative	0.0075	0.0461	0.0343
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0293	0.1962	1
Trypanosoma brucei	centrin, putative	0.0075	0.0461	0.1077
Trichomonas vaginalis	calmodulin, putative	0.0075	0.0461	0.1412
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0247	0.0758
Trichomonas vaginalis	conserved hypothetical protein	0.0075	0.0461	0.1412
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0247	0.0758
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Onchocerca volvulus		0.0044	0.0247	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0186	0.0166
Giardia lamblia	Hypothetical protein	0.0076	0.0473	0.1116
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0418	0.2828	0.8614
Trypanosoma brucei	centrin-3	0.0075	0.0461	0.1077
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0185	0.0166
Leishmania major	calcineurin B subunit, putative	0.0075	0.0461	0.1077
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0044	0.0247	0.0228
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0044	0.0247	0.0242
Brugia malayi	RNA, U transporter 1	0.0099	0.0628	0.061
Trypanosoma cruzi	conserved protein	0.0126	0.0812	0.0698
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0126	0.0812	0.0698
Echinococcus multilocularis	snurportin 1	0.0372	0.2507	0.2503
Trichomonas vaginalis	calmodulin, putative	0.0075	0.0461	0.1412
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Loa Loa (eye worm)	calpain family protein 1	0.0816	0.5571	0.5562
Echinococcus granulosus	EF hand domain containing family member A2	0.0075	0.0461	0.0456
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0044	0.0247	0.0398
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0044	0.0247	0.0228
Onchocerca volvulus	Cathepsin L homolog	0.0044	0.0247	0.0139
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.2196
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.0698
Brugia malayi	calpain 5	0.0126	0.0812	0.0795
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0482	0.3264	0.318
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0126	0.0812	0.2489
Brugia malayi	EF hand family protein	0.0076	0.0473	0.0455
Leishmania major	cathepsin L-like protease	0.0044	0.0247	0.0398
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0247	0.0398
Echinococcus granulosus	cpg binding protein	0.0037	0.0198	0.0193
Toxoplasma gondii	centrin	0.0075	0.0461	0.1077
Trypanosoma cruzi	programmed cell death 6 protein-like, putative	0.0075	0.0461	0.0343
Schistosoma mansoni	calpain-7 (C02 family)	0.0418	0.2828	0.2824
Plasmodium falciparum	serine repeat antigen 9	0.0044	0.0247	0.1813
Brugia malayi	fibroinase precursor	0.0044	0.0247	0.0229
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Toxoplasma gondii	hypothetical protein	0.0126	0.0812	0.2196
Toxoplasma gondii	cathepsin CPC1	0.0044	0.0247	0.0398
Echinococcus multilocularis	calpain A	0.1186	0.8114	0.8113
Trichomonas vaginalis	calcium binding protein, putative	0.0075	0.0461	0.1412
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.2196
Giardia lamblia	Cathepsin L precursor	0.0044	0.0247	0.0398
Brugia malayi	Importin beta-1 subunit	0.0035	0.0186	0.0167
Echinococcus granulosus	cathepsin l1	0.0044	0.0247	0.0242
Leishmania major	centrin, putative	0.0075	0.0461	0.1077
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0247	0.0398
Trypanosoma brucei	mitochondrial calcium uptake 1	0.0075	0.0461	0.1077
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0418	0.2828	0.2739
Giardia lamblia	Hypothetical protein	0.0044	0.0247	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0247	0.0228
Brugia malayi	cathepsin L-like precursor	0.0044	0.0247	0.0229
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.0453	0.0448
Trichomonas vaginalis	calcium binding protein, putative	0.0075	0.0461	0.1412
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0075	0.0461	0.184
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0418	0.2828	0.2739
Toxoplasma gondii	cathepsin CPC2	0.0044	0.0247	0.0398
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0044	0.0247	0.0242
Echinococcus granulosus	calpain A	0.0418	0.2828	0.2824
Leishmania major	hypothetical protein, unknown function	0.0126	0.0812	0.2196
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Echinococcus multilocularis	calbindin 32	0.0076	0.0473	0.0468
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0044	0.0247	0.0242
Trichomonas vaginalis	Crustacean calcium-binding protein, putative	0.0075	0.0461	0.1412
Brugia malayi	cathepsin L precursor	0.0044	0.0247	0.0229
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0044	0.0247	0.0127
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.2196
Echinococcus granulosus	cathepsin l1	0.0044	0.0247	0.0242
Trypanosoma brucei	Calpain-like protein 1.2	0.0126	0.0812	0.2196
Toxoplasma gondii	calmodulin CAM1	0.0076	0.0473	0.1116
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0044	0.0247	0.0229
Schistosoma mansoni	cathepsin B (C01 family)	0.0044	0.0247	0.0242
Trichomonas vaginalis	calpain, putative	0.0126	0.0812	0.2489
Trypanosoma brucei	calpain-like protein, putative	0.0418	0.2828	0.8614
Echinococcus granulosus	programmed cell death protein	0.0075	0.0461	0.0456
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0247	0.0398
Leishmania major	cathepsin L-like protease	0.0044	0.0247	0.0398
Plasmodium falciparum	serine repeat antigen 8	0.0044	0.0247	0.1813
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0044	0.0247	0.0242
Schistosoma mansoni	cathepsin F (C01 family)	0.0044	0.0247	0.0242
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.0698
Toxoplasma gondii	EF hand domain-containing protein	0.0075	0.0461	0.1077
Schistosoma mansoni	reticulocalbin	0.0076	0.0473	0.0468
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0247	0.0758
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0247	0.0398
Brugia malayi	Papain family cysteine protease containing protein	0.0044	0.0247	0.0229
Onchocerca volvulus		0.0044	0.0247	0.0139
Onchocerca volvulus		0.0044	0.0247	0.0139
Trichomonas vaginalis	hypothetical protein	0.0126	0.0812	0.2489
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0247	0.0228
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0418	0.2828	0.8614
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.2507	0.2492
Schistosoma mansoni	cathepsin C	0.0044	0.0247	0.0242
Schistosoma mansoni	ef hand domain family member A2	0.0075	0.0461	0.0456
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.0247	0.068
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0126	0.0812	0.0698
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0247	0.0229
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0247	0.0229
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0247	0.0398
Trichomonas vaginalis	calmodulin-2, putative	0.0075	0.0461	0.1412
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.1184	0.8102	0.8101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0044	0.0247	0.0758
Trichomonas vaginalis	calmodulin, putative	0.0076	0.0473	0.1449
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0247	0.0228
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Giardia lamblia	Cathepsin B precursor	0.0482	0.3264	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0044	0.0247	0.0758
Echinococcus granulosus	neurocalcin	0.0075	0.0461	0.0456
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0126	0.0812	0.0698
Onchocerca volvulus		0.0044	0.0247	0.0139
Schistosoma mansoni	calpain-7 (C02 family)	0.0418	0.2828	0.2824
Entamoeba histolytica	grainin 2	0.0075	0.0461	0.184
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0247	0.0758
Schistosoma mansoni	mitochondrial solute carrier	0.0075	0.0461	0.0456
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Trichomonas vaginalis	calmodulin, putative	0.0075	0.0461	0.1412
Loa Loa (eye worm)	hypothetical protein	0.0691	0.4705	0.4694
Echinococcus granulosus	calmodulin	0.0075	0.0461	0.0456
Trypanosoma brucei	cysteine peptidase, putative	0.0126	0.0812	0.2196
Echinococcus multilocularis	calmodulin	0.0075	0.0461	0.0456
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Brugia malayi	calpain 7	0.0418	0.2828	0.2815
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0186	0.0202
Giardia lamblia	Cathepsin B precursor	0.0044	0.0247	0.0398
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0126	0.0812	0.2489
Leishmania major	cathepsin L-like protease	0.0044	0.0247	0.0398
Brugia malayi	calpain D	0.0126	0.0812	0.0795
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0076	0.0473	0.0355
Echinococcus multilocularis	EF hand domain containing family member A2	0.0075	0.0461	0.0456
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0044	0.0247	0.1813
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0482	0.3264	1
Trichomonas vaginalis	conserved hypothetical protein	0.0075	0.0461	0.1412
Trypanosoma cruzi	kinesin, putative	0.0293	0.1962	0.1862
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0126	0.0812	0.0698
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0247	0.0398
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0044	0.0247	0.0242
Onchocerca volvulus		0.0044	0.0247	0.0139
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.2196
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.2196
Trichomonas vaginalis	calcium binding proteins, putative	0.0075	0.0461	0.1412
Echinococcus multilocularis	cathepsin L cysteine protease	0.0044	0.0247	0.0242
Plasmodium falciparum	importin beta, putative	0.0035	0.0186	0.0918
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.0186	0.0202
Trypanosoma brucei	calmodulin, putative	0.0076	0.0473	0.1116
Giardia lamblia	Cathepsin B precursor	0.0044	0.0247	0.0398
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0075	0.0461	0.0343
Leishmania major	cathepsin L-like protease	0.0044	0.0247	0.0398
Echinococcus multilocularis	cysteine protease	0.0044	0.0247	0.0242
Leishmania major	calpain family cysteine protease-like protein	0.0126	0.0812	0.2196
Schistosoma mansoni	cathepsin F (C01 family)	0.0044	0.0247	0.0242
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0247	0.0229
Trypanosoma brucei	hypothetical protein, conserved	0.0075	0.0461	0.1077
Giardia lamblia	Cathepsin L precursor	0.0044	0.0247	0.0398
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0044	0.0247	0.0398
Echinococcus multilocularis	programmed cell death protein	0.0075	0.0461	0.0456
Onchocerca volvulus	Cathepsin F homolog	0.0044	0.0247	0.0139
Onchocerca volvulus		0.0075	0.0461	0.0611
Toxoplasma gondii	centrin, putative	0.0075	0.0461	0.1077
Loa Loa (eye worm)	programmed cell death protein 6	0.0076	0.0473	0.0454
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0044	0.0247	0.0228
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0044	0.0247	0.0228
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.0698
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0247	0.0398
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0482	0.3264	0.326
Echinococcus multilocularis	hypothetical protein	0.0418	0.2828	0.2824
Entamoeba histolytica	hypothetical protein	0.0028	0.014	0.0098
Toxoplasma gondii	cathepsin CPL	0.0044	0.0247	0.0398
Giardia lamblia	Cathepsin B precursor	0.0482	0.3264	1
Trichomonas vaginalis	calcium binding protein, putative	0.0075	0.0461	0.1412
Schistosoma mansoni	hypothetical protein	0.0372	0.2507	0.2503
Echinococcus multilocularis	sarcoplasmic calcium binding protein	0.0075	0.0461	0.0456
Trypanosoma cruzi	calmodulin, putative	0.0075	0.0461	0.0343
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.1184	0.8102	0.8101
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0247	0.0229
Trichomonas vaginalis	calcium binding protein, putative	0.0075	0.0461	0.1412
Echinococcus multilocularis	cathepsin L cysteine protease	0.0044	0.0247	0.0242
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0075	0.0461	0.184
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0418	0.2828	0.2824
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0026	0.0122	0.0117
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0044	0.0247	0.1813
Toxoplasma gondii	calpain family cysteine protease domain-containing protein	0.0126	0.0812	0.2196
Trypanosoma brucei	centrin, putative	0.0075	0.0461	0.1077
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0044	0.0247	0.0242
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0247	0.0758
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0482	0.3264	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0044	0.0247	0.0462
Echinococcus granulosus	calcium uptake protein 1	0.0076	0.0473	0.0468
Trypanosoma cruzi	I/6 autoantigen, putative	0.0075	0.0461	0.0343
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.0247	0.068
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0247	0.0229
Brugia malayi	cathepsin L-like cysteine proteinase	0.0044	0.0247	0.0229
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0418	0.2828	0.2739
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0247	0.0758
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0044	0.0247	0.0242
Plasmodium vivax	calpain, putative	0.0418	0.2828	1
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.0247	0.068
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Loa Loa (eye worm)	hypothetical protein	0.1109	0.7587	0.7582
Giardia lamblia	Cathepsin L precursor	0.0044	0.0247	0.0398
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.1184	0.8102	0.8101
Trichomonas vaginalis	calcineurin B subunit, putative	0.0075	0.0461	0.1412
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0247	0.0758
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0075	0.0461	0.0343
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0044	0.0247	0.0242
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0247	0.0758
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0418	0.2828	0.2739
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0247	0.0228
Leishmania major	centrin, putative,caltractin, putative	0.0075	0.0461	0.1077
Loa Loa (eye worm)	calpain family protein 1	0.1109	0.7587	0.7582
Plasmodium falciparum	serine repeat antigen 3	0.0044	0.0247	0.1813
Echinococcus granulosus	sarcoplasmic calcium binding protein	0.0075	0.0461	0.0456
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0044	0.0247	0.0229
Leishmania major	hypothetical protein, conserved	0.0075	0.0461	0.1077
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Leishmania major	calmodulin-like protein	0.0075	0.0461	0.1077
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0044	0.0247	0.0398
Schistosoma mansoni	Sarcoplasmic calcium-binding protein (SCP).	0.0075	0.0461	0.0456
Trichomonas vaginalis	calcineurin B subunit, putative	0.0076	0.0473	0.1449
Trypanosoma brucei	calpain, putative	0.0126	0.0812	0.2196
Entamoeba histolytica	calcium-binding protein, putative	0.0075	0.0461	0.184
Brugia malayi	Papain family cysteine protease containing protein	0.0044	0.0247	0.0229
Echinococcus multilocularis	cysteine protease	0.0044	0.0247	0.0242
Onchocerca volvulus	Cathepsin L homolog	0.0044	0.0247	0.0139
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.0247	0.068
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0247	0.0398
Leishmania major	calmodulin, putative	0.0075	0.0461	0.1077
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0044	0.0247	0.0462
Trypanosoma cruzi	centrin-3	0.0075	0.0461	0.0343
Trichomonas vaginalis	calpain, putative	0.0126	0.0812	0.2489
Giardia lamblia	Cathepsin B precursor	0.0044	0.0247	0.0398
Echinococcus granulosus	calpain A	0.1186	0.8114	0.8113
Toxoplasma gondii	troponin c, isotype gamma, putative	0.0075	0.0461	0.1077
Plasmodium falciparum	calpain	0.0126	0.0812	1
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0075	0.0461	0.1251
Leishmania major	programmed cell death 6 protein-like protein	0.0075	0.0461	0.1077
Trichomonas vaginalis	calmodulin, putative	0.0075	0.0461	0.1412
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0044	0.0247	0.0229
Echinococcus granulosus	neuronal calcium sensor	0.0075	0.0461	0.0456
Schistosoma mansoni	hypothetical protein	0.0075	0.0461	0.0456
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0044	0.0247	0.0242
Leishmania major	kinesin, putative	0.0293	0.1962	0.5855
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0247	0.0758
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0186	0.0181
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.014	0.043
Trypanosoma brucei	protein I/6	0.0075	0.0461	0.1077
Echinococcus granulosus	EF HAND 1 calcium binding site	0.0075	0.0461	0.0456
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0247	0.0229
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.2196
Schistosoma mansoni	centrin	0.0075	0.0461	0.0456
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0247	0.0127
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0126	0.0812	0.2489
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0044	0.0247	0.0462
Brugia malayi	programmed cell death protein 6	0.0075	0.0461	0.0443
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.0698
Schistosoma mansoni	cathepsin S (C01 family)	0.0044	0.0247	0.0242
Onchocerca volvulus	Cathepsin L homolog	0.0044	0.0247	0.0139
Loa Loa (eye worm)	ctsf protein	0.0044	0.0247	0.0228
Leishmania major	phospholipase c-like protein	0.0075	0.0461	0.1077
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.2196
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0044	0.0247	0.0462
Giardia lamblia	Cysteine protease	0.0044	0.0247	0.0398
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0247	0.0398
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.0698
Leishmania major	cathepsin L-like protease	0.0044	0.0247	0.0398
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0247	0.0398
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0247	0.0758
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0418	0.2828	0.8614
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0044	0.0247	0.0242
Brugia malayi	Papain family cysteine protease containing protein	0.0044	0.0247	0.0229
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0126	0.0812	0.2196
Echinococcus multilocularis	calpain 5	0.0418	0.2828	0.2824
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0186	0.0202
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0044	0.0247	0.068
Trypanosoma cruzi	cysteine proteinase, putative	0.0044	0.0247	0.0127
Loa Loa (eye worm)	calpain	0.0418	0.2828	0.2814
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0044	0.0247	0.0462
Schistosoma mansoni	reticulocalbin	0.0075	0.0461	0.0456
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Echinococcus granulosus	cysteine protease	0.0044	0.0247	0.0242
Brugia malayi	calpain family protein 1	0.1109	0.7587	0.7582
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Trypanosoma brucei	Calpain-like protein CALP1.3	0.0126	0.0812	0.2196
Entamoeba histolytica	grainin, putative	0.0076	0.0473	0.1906
Trichomonas vaginalis	calmodulin, putative	0.0075	0.0461	0.1412
Leishmania major	cathepsin L-like protease	0.0044	0.0247	0.0398
Echinococcus multilocularis	centrin 2	0.0075	0.0461	0.0456
Entamoeba histolytica	protein kinase, putative	0.0293	0.1962	1
Trichomonas vaginalis	centrin, putative	0.0075	0.0461	0.1412
Schistosoma mansoni	rab	0.0075	0.0461	0.0456
Brugia malayi	calpain family protein 1	0.1109	0.7587	0.7582
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.2196
Trypanosoma brucei	Component of motile flagella 41	0.0075	0.0461	0.1077
Leishmania major	centrin, putative	0.0075	0.0461	0.1077
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0044	0.0247	0.0462
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.2196
Schistosoma mansoni	neuronal calcium sensor	0.0075	0.0461	0.0456
Trypanosoma brucei	calpain-like protein, putative	0.0418	0.2828	0.8614
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0026	0.0122	0.0117
Entamoeba histolytica	calpain family cysteine protease, putative	0.0126	0.0812	0.3751
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0418	0.2828	0.2739
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0044	0.0247	0.0228
Schistosoma mansoni	calcium binding atopy-related autoantigen	0.0076	0.0473	0.0468
Trypanosoma brucei	calpain-like protein, putative	0.0418	0.2828	0.8614
Echinococcus granulosus	calumenin	0.0076	0.0473	0.0468
Plasmodium vivax	importin-beta 2, putative	0.0035	0.0186	0.0234
Brugia malayi	Papain family cysteine protease containing protein	0.0044	0.0247	0.0229
Echinococcus granulosus	snurportin 1	0.0372	0.2507	0.2503
Plasmodium vivax	serine-repeat antigen (SERA)	0.0044	0.0247	0.0462
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Plasmodium falciparum	serine repeat antigen 6	0.0044	0.0247	0.1813
Schistosoma mansoni	neuronal calcium sensor	0.0075	0.0461	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0983	0.672	0.6714
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0126	0.0812	0.2489
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0044	0.0247	0.068
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0247	0.0228
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0044	0.0247	0.0758
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.2196
Trypanosoma cruzi	major cysteine proteinase, putative	0.0044	0.0247	0.0127
Onchocerca volvulus		0.0691	0.4705	1
Loa Loa (eye worm)	cathepsin B	0.0482	0.3264	0.325
Entamoeba histolytica	calmodulin, putative	0.0075	0.0461	0.184
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0126	0.0812	0.0698
Trichomonas vaginalis	centrin, putative	0.0075	0.0461	0.1412
Trypanosoma cruzi	centrin, putative	0.0075	0.0461	0.0343
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0247	0.0398
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.2196
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0247	0.0127
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.0247	0.068
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0247	0.0228
Leishmania major	hypothetical protein, conserved	0.0076	0.0473	0.1116
Brugia malayi	Calmodulin-like protein	0.0075	0.0461	0.0443
Schistosoma mansoni	calpain C (C02 family)	0.0418	0.2828	0.2824
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0044	0.0247	0.1813
Schistosoma mansoni	centrin-related	0.0075	0.0461	0.0456
Trypanosoma brucei	antigen, putative	0.0418	0.2828	0.8614
Trichomonas vaginalis	ran, putative	0.0026	0.0122	0.0375
Trichomonas vaginalis	calpain, putative	0.0126	0.0812	0.2489
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0044	0.0247	0.0127
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0126	0.0812	0.0698
Echinococcus granulosus	calpain	0.0418	0.2828	0.2824
Echinococcus multilocularis	calmodulin	0.0075	0.0461	0.0456
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0044	0.0247	0.1813
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Giardia lamblia	Hypothetical protein	0.0044	0.0247	0.0398
Plasmodium falciparum	centrin-1	0.0075	0.0461	0.4906
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Trypanosoma brucei	I/6 autoantigen	0.0075	0.0461	0.1077
Echinococcus multilocularis	cathepsin L	0.0044	0.0247	0.0242
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0247	0.0758
Brugia malayi	calcium-binding protein	0.0075	0.0461	0.0443
Echinococcus granulosus	calbindin 32	0.0076	0.0473	0.0468
Trypanosoma brucei	calpain-like protein, putative	0.0418	0.2828	0.8614
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0126	0.0812	0.2489
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0418	0.2828	0.8614
Plasmodium falciparum	serine repeat antigen 5	0.0044	0.0247	0.1813
Echinococcus granulosus	cathepsin L cysteine protease	0.0044	0.0247	0.0242
Giardia lamblia	Cathepsin B precursor	0.0482	0.3264	1
Giardia lamblia	Cathepsin L precursor	0.0044	0.0247	0.0398
Trypanosoma cruzi	centrin, putative	0.0075	0.0461	0.0343
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Plasmodium vivax	hypothetical protein, conserved	0.0076	0.0473	0.1295
Trypanosoma brucei	cytoskeleton-associated protein CAP5.5, putative	0.0126	0.0812	0.2196
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0418	0.2828	0.2739
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0185	0.0165
Echinococcus multilocularis	calpain family protein 1, d	0.0816	0.5571	0.5569
Echinococcus multilocularis	cathepsin L	0.0044	0.0247	0.0242
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.0247	0.068
Trypanosoma cruzi	cysteine proteinase, putative	0.0044	0.0247	0.0127
Trypanosoma brucei	calpain, putative	0.0126	0.0812	0.2196
Schistosoma mansoni	hypothetical protein	0.0075	0.0461	0.0456
Echinococcus granulosus	EF hand domain containing family member A2	0.0076	0.0473	0.0468
Giardia lamblia	Cathepsin L precursor	0.0044	0.0247	0.0398
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0044	0.0247	0.0758
Trypanosoma brucei	kinesin, putative	0.0293	0.1962	0.5855
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0247	0.0127
Entamoeba histolytica	calmodulin, putative	0.0075	0.0461	0.184
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0044	0.0247	0.1813
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0044	0.0247	0.0758
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.014	0.043
Trichomonas vaginalis	calmodulin, putative	0.0075	0.0461	0.1412
Leishmania major	calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.2196
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0126	0.0812	0.0698
Trypanosoma brucei	Calpain-like protein 2	0.0126	0.0812	0.2196
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0044	0.0247	0.0462
Leishmania major	protein kinase, putative	0.0075	0.0461	0.1077
Onchocerca volvulus		0.0044	0.0247	0.0139
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0075	0.0461	0.0343
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0418	0.2828	0.2739
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.014	0.0018
Onchocerca volvulus		0.0044	0.0247	0.0139
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0044	0.0247	0.0242
Loa Loa (eye worm)	calpain 5	0.0293	0.1962	0.1946
Giardia lamblia	Cysteine protease	0.0044	0.0247	0.0398
Plasmodium vivax	unspecified product	0.0044	0.0247	0.0462
Plasmodium vivax	vivapain-3	0.0044	0.0247	0.0462
Giardia lamblia	Cathepsin B precursor	0.0044	0.0247	0.0398
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Trichomonas vaginalis	DNA-dependent protein kinase catalytic subunit-interacting protein, putative	0.0075	0.0461	0.1412
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0126	0.0812	0.2489
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0044	0.0247	0.0758
Onchocerca volvulus		0.0076	0.0473	0.0637
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.2196
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.002	0.0015
Trypanosoma cruzi	kinesin, putative	0.0293	0.1962	0.1862
Giardia lamblia	Encystation-specific protease	0.0044	0.0247	0.0398
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.0698
Echinococcus granulosus	calpain 5	0.0418	0.2828	0.2824
Trypanosoma cruzi	mitochondrial calcium uptake 1, putative	0.0075	0.0461	0.0343
Echinococcus granulosus	importin subunit beta 1	0.0035	0.0186	0.0181
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Leishmania major	calpain protease-like protein	0.0126	0.0812	0.2196
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.002	0.0015
Schistosoma mansoni	hypothetical protein	0.0126	0.0812	0.0808
Trypanosoma brucei	glucosamine 6-phosphate n-acetyltransferase	0.0126	0.0812	0.2196
Trypanosoma brucei	caltractin, putative	0.0075	0.0461	0.1077
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0812	0.0698
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0418	0.2828	0.2739
Entamoeba histolytica	hypothetical protein, conserved	0.0076	0.0473	0.1906
Loa Loa (eye worm)	fibroinase	0.0044	0.0247	0.0228
Trypanosoma cruzi	cruzipain precursor, putative	0.0044	0.0247	0.0127
Echinococcus multilocularis	calpain 7 (C02 family)	0.0418	0.2828	0.2824
Trypanosoma cruzi	calmodulin, putative	0.0075	0.0461	0.0343
Trypanosoma brucei	CAMK/CAMKL family protein kinase, putative	0.0075	0.0461	0.1077
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0247	0.0228
Plasmodium falciparum	serine repeat antigen 2	0.0044	0.0247	0.1813
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.1184	0.8102	0.8101
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0044	0.0247	0.1813
Echinococcus multilocularis	calumenin	0.0076	0.0473	0.0468
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0247	0.0398
Leishmania major	cysteine peptidase A (CPA)	0.0044	0.0247	0.0398
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0044	0.0247	0.0242
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0247	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0247	0.0228
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0247	0.0758
Trypanosoma brucei	hypothetical protein	0.0126	0.0812	0.2196
Schistosoma mansoni	neuronal calcium sensor	0.0075	0.0461	0.0456
Trypanosoma brucei	Calpain-like protein 1.1	0.0126	0.0812	0.2196
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0044	0.0247	0.0758
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0126	0.0812	0.0698
Trypanosoma cruzi	I/6 autoantigen, putative	0.0075	0.0461	0.0343
Schistosoma mansoni	cpg binding protein	0.0037	0.0198	0.0193
Echinococcus multilocularis	programmed cell death protein	0.0075	0.0461	0.0456
Brugia malayi	calpain 5	0.0293	0.1962	0.1947
Entamoeba histolytica	cysteine proteinase 2	0.0044	0.0247	0.068
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0247	0.068
Plasmodium vivax	vivapain-1	0.0044	0.0247	0.0462
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0044	0.0247	0.0229
Plasmodium vivax	serine-repeat antigen (SERA)	0.0044	0.0247	0.0462
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0044	0.0247	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0812	0.0794
Plasmodium vivax	vivapain-2	0.0044	0.0247	0.0462
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0247	0.0229
Leishmania major	cathepsin L-like protease	0.0044	0.0247	0.0398
Schistosoma mansoni	calmodulin	0.0075	0.0461	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0461	0.0442
Schistosoma mansoni	calmodulin	0.0075	0.0461	0.0456
Giardia lamblia	Cathepsin L-like protease	0.0044	0.0247	0.0398
Toxoplasma gondii	calcium-dependent protein kinase	0.0076	0.0473	0.1116

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	5.0119 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	6.5131 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	= 7.0795 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1544940

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1406941