Detailed information for compound 1516959

Basic information

Technical information
  • TDR Targets ID: 1516959
  • Name: N-[5-[(4-chlorophenyl)methyl-methylsulfamoyl] -1,3,4-thiadiazol-2-yl]pentanamide
  • MW: 402.919 | Formula: C15H19ClN4O3S2
  • H donors: 1 H acceptors: 5 LogP: 2.85 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC(=O)Nc1nnc(s1)S(=O)(=O)N(Cc1ccc(cc1)Cl)C
  • InChi: 1S/C15H19ClN4O3S2/c1-3-4-5-13(21)17-14-18-19-15(24-14)25(22,23)20(2)10-11-6-8-12(16)9-7-11/h6-9H,3-5,10H2,1-2H3,(H,17,18,21)
  • InChiKey: QZNNYFSZPBNPBH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[5-[(4-chlorophenyl)methyl-methyl-sulfamoyl]-1,3,4-thiadiazol-2-yl]pentanamide
  • N-[5-[(4-chlorobenzyl)-methyl-sulfamoyl]-1,3,4-thiadiazol-2-yl]valeramide
  • E880-0749
  • NCGC00126070-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0229 0.0016
Loa Loa (eye worm) CYP4Cod1 0.0043 0.0337 0.035
Brugia malayi Cytochrome P450 family protein 0.0055 0.0501 0.052
Loa Loa (eye worm) calpain family protein 1 0.059 0.8008 0.8317
Entamoeba histolytica cysteine protease, putative 0.0184 0.2307 1
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0413 0.0429
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0038 0.026 0.026
Leishmania major hypothetical protein, conserved 0.0034 0.0206 0.0572
Brugia malayi Trypsin family protein 0.0023 0.0062 0.0064
Onchocerca volvulus 0.0035 0.0229 0.0468
Onchocerca volvulus 0.0287 0.3758 0.7689
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.059 0.8008 0.8317
Leishmania major histone deacetylase, putative 0.0067 0.0669 0.1857
Trypanosoma cruzi cysteine peptidase, putative 0.0276 0.3601 0.374
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0229 0.0016
Trypanosoma brucei protein I/6 0.0033 0.02 0.0554
Entamoeba histolytica glycogen phosphorylase, putative 0.0109 0.1257 0.5018
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0229 0.0082
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.1864
Schistosoma mansoni neuronal calcium sensor 0.0033 0.02 0.0207
Echinococcus multilocularis calmodulin 0.0033 0.02 0.02
Entamoeba histolytica glycogen phosphorylase, putative 0.0109 0.1257 0.5018
Loa Loa (eye worm) hypothetical protein 0.0038 0.026 0.027
Brugia malayi cathepsin B-like cysteine proteinase 0.0705 0.9629 1
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0062 0.0599 0.0599
Trypanosoma cruzi cysteine protease, putative 0.0104 0.1197 0.1243
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0104 0.1197 0.1243
Echinococcus multilocularis calcium uptake protein 1 0.0034 0.0206 0.0206
Giardia lamblia Cathepsin B precursor 0.0253 0.3282 1
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.1864
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0067 0.0671 0.1327
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1197 0.3323
Brugia malayi proteasome subunit beta type 1 0.0062 0.0599 0.0622
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.044 0.0457
Brugia malayi calpain 7 0.0223 0.2855 0.2964
Brugia malayi calpain 5 0.0067 0.0671 0.0697
Leishmania major centrin, putative 0.0033 0.02 0.0554
Trypanosoma cruzi cysteine peptidase, putative 0.0104 0.1197 0.1243
Giardia lamblia Cysteine protease 0.005 0.044 0.076
Leishmania major calmodulin-like protein 0.0033 0.02 0.0554
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0067 0.0671 0.1864
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0038 0.027 0.1169
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0229 0.0801
Echinococcus granulosus calpain A 0.0223 0.2855 0.2855
Loa Loa (eye worm) hypothetical protein 0.0033 0.02 0.0207
Loa Loa (eye worm) hypothetical protein 0.0038 0.026 0.027
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0434 0.0742
Trypanosoma brucei histone deacetylase 1 0.0067 0.0669 0.1857
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.0697
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0184 0.2307 0.5929
Schistosoma mansoni reticulocalbin 0.0033 0.02 0.0207
Echinococcus granulosus Regulator of G protein signaling 20 0.0038 0.026 0.026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1053 0.1053
Loa Loa (eye worm) hypothetical protein 0.0033 0.02 0.0207
Plasmodium vivax proteasome subunit beta type-5, putative 0.0079 0.0848 0.297
Brugia malayi Proteasome A-type and B-type family protein 0.0079 0.0848 0.0881
Echinococcus granulosus glycogen phosphorylase 0.0109 0.1257 0.1257
Leishmania major cathepsin L-like protease 0.0184 0.2307 0.6406
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0062 0.0064
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0223 0.2855 0.7926
Onchocerca volvulus 0.0184 0.2307 0.4722
Trypanosoma brucei cytochrome P450, putative 0.0043 0.0337 0.0935
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0079 0.0848 0.2087
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0054 0.049 0.0509
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0223 0.2855 0.2964
Loa Loa (eye worm) hypothetical protein 0.005 0.044 0.0457
Schistosoma mansoni neuronal calcium sensor 0.0033 0.02 0.0207
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0253 0.3282 0.3408
Toxoplasma gondii calmodulin CAM1 0.0034 0.0206 0.0628
Mycobacterium ulcerans putative transglutaminase-like protein 0.0035 0.0224 0.2067
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0206 0.0722
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0247 0.0754
Loa Loa (eye worm) hypothetical protein 0.0023 0.0062 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.2307 0.5929
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.005 0.044 0.1906
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0434 0.0451
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.0697
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0434 0.0434
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0062 0.0064
Plasmodium vivax unspecified product 0.005 0.044 0.1541
Trypanosoma brucei mitochondrial calcium uptake 1 0.0033 0.02 0.0554
Trypanosoma cruzi cysteine peptidase, putative 0.0276 0.3601 0.374
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.005 0.044 0.1541
Leishmania major centrin, putative,caltractin, putative 0.0033 0.02 0.0554
Echinococcus granulosus cathepsin L 0.0104 0.1197 0.1197
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0043 0.0337 0.3498
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0247 0.0247
Echinococcus granulosus EF hand domain containing family member A2 0.0033 0.02 0.02
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.026 0.026
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0229 0.0237
Entamoeba histolytica protein kinase, putative 0.0156 0.1922 0.8174
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0623 0.8475 0.8475
Mycobacterium tuberculosis Conserved protein 0.0035 0.0229 0.0016
Mycobacterium ulcerans lipase LipD 0.0035 0.0229 0.2121
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0062 0.0064
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0033 0.02 0.0207
Schistosoma mansoni centrin-related 0.0033 0.02 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0671 0.1327
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.049 0.0509
Schistosoma mansoni glycogen phosphorylase 0.0109 0.1257 0.1306
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0184 0.2307 0.2307
Brugia malayi hypothetical protein 0.0229 0.2946 0.3059
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0434 0.066
Echinococcus granulosus cathepsin L cysteine proteinase 0.0184 0.2307 0.2307
Echinococcus granulosus tissue type plasminogen activator 0.0039 0.0281 0.0281
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0033 0.02 0.0554
Brugia malayi hypothetical protein 0.0038 0.026 0.027
Loa Loa (eye worm) hypothetical protein 0.0148 0.1811 0.1881
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0267 0.0277
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.3601 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0229 0.0016
Schistosoma mansoni hypothetical protein 0.0067 0.0671 0.0697
Echinococcus granulosus calpain 7 C02 family 0.0223 0.2855 0.2855
Toxoplasma gondii calcium-dependent protein kinase 0.0034 0.0212 0.0647
Brugia malayi Cathepsin L-like precursor 0.013 0.155 0.161
Brugia malayi calpain D 0.0067 0.0671 0.0697
Brugia malayi calpain family protein 1 0.059 0.8008 0.8317
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.1864
Brugia malayi Cathepsin L-like precursor 0.0184 0.2307 0.2396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.013 0.155 0.38
Echinococcus granulosus calpain A 0.0624 0.8481 0.8481
Brugia malayi hypothetical protein 0.0148 0.1811 0.1881
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0062 0.0064
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0062 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.005 0.044 0.0676
Echinococcus multilocularis cathepsin L cysteine protease 0.0184 0.2307 0.2307
Echinococcus granulosus EF hand domain containing family member A2 0.0034 0.0206 0.0206
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0038 0.027 0.0197
Onchocerca volvulus 0.0034 0.0206 0.0422
Onchocerca volvulus 0.0023 0.0062 0.0127
Schistosoma mansoni histone deacetylase 0.0067 0.0669 0.0695
Brugia malayi Calmodulin-like protein 0.0033 0.02 0.0207
Echinococcus multilocularis EF hand domain containing family member A2 0.0033 0.02 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.026 0.0171
Loa Loa (eye worm) proteasome subunit beta type 1 0.0062 0.0599 0.0622
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.1864
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.026 0.027
Entamoeba histolytica glycogen phosphorylase, putative 0.0047 0.0392 0.0913
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0023 0.0062 0.0064
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.0697
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0223 0.2855 0.2964
Entamoeba histolytica cysteine protease, putative 0.005 0.044 0.114
Brugia malayi carbohydrate phosphorylase 0.0109 0.1257 0.1306
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0038 0.027 0.028
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0247 0.0247
Brugia malayi hypothetical protein 0.0023 0.0062 0.0064
Brugia malayi cathepsin Z-like cysteine proteinase 0.005 0.044 0.0457
Echinococcus granulosus tumor protein p63 0.0331 0.438 0.438
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0253 0.3282 0.9113
Plasmodium falciparum serine repeat antigen 8 0.005 0.044 0.1906
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.1864
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0222 0.2844 0.2954
Loa Loa (eye worm) calpain D 0.0067 0.0671 0.0697
Trypanosoma brucei hypothetical protein 0.0067 0.0671 0.1864
Brugia malayi Histone deacetylase 1 0.0067 0.0669 0.0695
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.1864
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.2307 0.5929
Schistosoma mansoni neuronal calcium sensor 0.0033 0.02 0.0207
Trichomonas vaginalis histone deacetylase, putative 0.0067 0.0669 0.1321
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0342 0.0342
Echinococcus multilocularis cathepsin b 0.0705 0.9629 0.9629
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0039 0.0281 0.0985
Loa Loa (eye worm) calpain 5 0.0156 0.1916 0.199
Trypanosoma brucei caltractin, putative 0.0033 0.02 0.0554
Brugia malayi Cathepsin L-like precursor 0.0054 0.049 0.0509
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0034 0.0206 0.0214
Giardia lamblia Cathepsin L precursor 0.005 0.044 0.076
Onchocerca volvulus 0.0023 0.0062 0.0127
Brugia malayi Cathepsin L-like precursor 0.0184 0.2307 0.2396
Entamoeba histolytica cysteine proteinase, putative 0.013 0.155 0.6408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.3601 1
Onchocerca volvulus 0.0033 0.02 0.0408
Loa Loa (eye worm) hypothetical protein 0.0039 0.0281 0.0292
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.005 0.044 0.0457
Trypanosoma cruzi I/6 autoantigen, putative 0.0033 0.02 0.0207
Loa Loa (eye worm) EF hand family protein 0.0033 0.02 0.0207
Schistosoma mansoni ef hand domain family member A2 0.0033 0.02 0.0207
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0184 0.2307 0.5929
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0062 0.0599 0.2597
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.2307 0.5929
Plasmodium vivax histone deacetylase 1, putative 0.0067 0.0669 0.2343
Plasmodium falciparum serine repeat antigen 7 0.005 0.044 0.1906
Giardia lamblia Cathepsin L precursor 0.005 0.044 0.076
Plasmodium falciparum cysteine proteinase falcipain 3 0.0184 0.2307 1
Trypanosoma cruzi kinesin, putative 0.0156 0.1916 0.199
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0229 0.0068
Echinococcus granulosus histone deacetylase 1 0.0067 0.0669 0.0669
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.2307 0.5929
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0229 0.0016
Leishmania major calpain protease-like protein 0.0067 0.0671 0.1864
Loa Loa (eye worm) hypothetical protein 0.005 0.044 0.0457
Onchocerca volvulus 0.0023 0.0062 0.0127
Leishmania major cathepsin L-like protease 0.0184 0.2307 0.6406
Brugia malayi Papain family cysteine protease containing protein 0.005 0.044 0.0457
Plasmodium vivax SET domain protein, putative 0.0037 0.0247 0.0866
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1053 0.1053
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2899 1
Brugia malayi cathepsin L precursor 0.005 0.044 0.0457
Loa Loa (eye worm) hypothetical protein 0.0035 0.0229 0.0237
Echinococcus granulosus calmodulin 0.0033 0.02 0.02
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0023 0.0062 0.0062
Trypanosoma brucei calpain, putative 0.0067 0.0671 0.1864
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.044 0.0676
Loa Loa (eye worm) hypothetical protein 0.0054 0.049 0.0509
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0023 0.0062 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0184 0.2307 0.5929
Echinococcus multilocularis Glycosyl transferase, family 35 0.0109 0.1257 0.1257
Loa Loa (eye worm) hypothetical protein 0.0023 0.0062 0.0064
Plasmodium falciparum proteasome subunit beta type-5 0.0079 0.0848 0.3675
Trypanosoma brucei I/6 autoantigen 0.0033 0.02 0.0554
Leishmania major calcineurin B subunit, putative 0.0033 0.02 0.0554
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.0697
Onchocerca volvulus 0.0035 0.0224 0.0459
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0062 0.0599 0.1664
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.1864
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0247 0.0257
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.1864
Echinococcus granulosus geminin 0.0329 0.4354 0.4354
Onchocerca volvulus Cathepsin L homolog 0.0184 0.2307 0.4722
Toxoplasma gondii centrin 0.0033 0.02 0.0608
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.044 0.0457
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0558 0.17
Echinococcus multilocularis enteropeptidase 0.0023 0.0062 0.0062
Toxoplasma gondii troponin c, isotype gamma, putative 0.0033 0.02 0.0608
Toxoplasma gondii EFHC1, putative 0.0033 0.02 0.0608
Brugia malayi Cytochrome P450 family protein 0.0043 0.0337 0.035
Schistosoma mansoni hypothetical protein 0.0329 0.4354 0.4521
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.026 0.026
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0062 0.0599 0.1124
Trypanosoma cruzi cruzipain precursor, putative 0.0054 0.049 0.0509
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1197 0.3323
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.026 0.026
Trypanosoma cruzi cruzipain precursor, putative 0.0276 0.3601 0.374
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1053 0.1094
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.026 0.0171
Schistosoma mansoni regulator of G protein signaling 0.0038 0.026 0.027
Trypanosoma cruzi calmodulin, putative 0.0033 0.02 0.0207
Mycobacterium ulcerans beta-lactamase 0.0035 0.0229 0.2121
Giardia lamblia Cathepsin B precursor 0.005 0.044 0.076
Trichomonas vaginalis set domain proteins, putative 0.0287 0.3754 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0104 0.1197 0.5187
Onchocerca volvulus 0.005 0.044 0.09
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1053 0.1094
Plasmodium falciparum serine repeat antigen 2 0.005 0.044 0.1906
Echinococcus multilocularis Regulator of G protein signaling 20 0.0038 0.026 0.026
Entamoeba histolytica hypothetical protein 0.0038 0.026 0.0288
Brugia malayi Papain family cysteine protease containing protein 0.005 0.044 0.0457
Trichomonas vaginalis conserved hypothetical protein 0.005 0.044 0.0676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.2307 0.5929
Echinococcus multilocularis glycogen phosphorylase 0.0109 0.1257 0.1257
Leishmania major centrin, putative 0.0033 0.02 0.0554
Entamoeba histolytica hypothetical protein 0.0043 0.0342 0.0678
Echinococcus multilocularis calumenin 0.0034 0.0206 0.0206
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0705 0.9629 1
Mycobacterium leprae Probable lipase LipE 0.0035 0.0229 0.0068
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0558 0.0579
Trypanosoma brucei antigen, putative 0.0223 0.2855 0.7926
Trypanosoma cruzi 20S proteasome subunit 0.0038 0.027 0.028
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0067 0.0669 0.1321
Brugia malayi PXA domain containing protein 0.0038 0.026 0.027
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0034 0.0206 0.0214
Onchocerca volvulus 0.0037 0.0247 0.0506
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.026 0.026
Brugia malayi cathepsin L-like precursor 0.013 0.155 0.161
Brugia malayi Trypsin family protein 0.0023 0.0062 0.0064
Echinococcus granulosus microtubule associated protein 2 0.0677 0.9224 0.9224
Giardia lamblia Cathepsin B precursor 0.0253 0.3282 1
Entamoeba histolytica grainin, putative 0.0034 0.0206 0.0031
Leishmania major cysteine peptidase A (CPA) 0.0184 0.2307 0.6406
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.005 0.044 0.1906
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0223 0.2855 0.7926
Echinococcus granulosus cathepsin l1 0.0184 0.2307 0.2307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.2307 0.5929
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.005 0.044 0.1906
Brugia malayi cathepsin L-like cysteine proteinase 0.005 0.044 0.0457
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0434 0.0451
Giardia lamblia Proteasome subunit beta type 2 0.0038 0.027 0.0207
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0229 0.0237
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0434 0.066
Trypanosoma brucei calmodulin, putative 0.0034 0.0206 0.0572
Schistosoma mansoni cathepsin F (C01 family) 0.0184 0.2307 0.2396
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.005 0.044 0.1541
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0623 0.8475 0.8801
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.022 0.022
Echinococcus multilocularis calpain 5 0.0223 0.2855 0.2855
Echinococcus granulosus Mastin 0.0023 0.0062 0.0062
Schistosoma mansoni calpain C (C02 family) 0.0223 0.2855 0.2964
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0223 0.2855 0.7926
Loa Loa (eye worm) beta-lactamase 0.0035 0.0229 0.0237
Entamoeba histolytica histone deacetylase, putative 0.0067 0.0669 0.2227
Brugia malayi Cathepsin L-like precursor 0.0184 0.2307 0.2396
Echinococcus granulosus cpg binding protein 0.003 0.015 0.015
Schistosoma mansoni hypothetical protein 0.0043 0.0342 0.0356
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0067 0.0671 0.1327
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0067 0.0671 0.1327
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.005 0.044 0.0457
Entamoeba histolytica cysteine protease, putative 0.005 0.044 0.114
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.1864
Schistosoma mansoni cathepsin F (C01 family) 0.0184 0.2307 0.2396
Brugia malayi calcium-binding protein 0.0033 0.02 0.0207
Entamoeba histolytica cysteine protease, putative 0.0104 0.1197 0.4732
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.3267 0.3393
Entamoeba histolytica cysteine protease, putative 0.0104 0.1197 0.4732
Onchocerca volvulus Cathepsin L homolog 0.005 0.044 0.09
Giardia lamblia Proteasome subunit beta type 1 0.0062 0.0599 0.1278
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0062 0.0599 0.0622
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.005 0.044 0.1541
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.1864
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.005 0.044 0.076
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0038 0.0267 0.0277
Onchocerca volvulus 0.0184 0.2307 0.4722
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0229 0.0082
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.1864
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0067 0.0671 0.1864
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.0206 0.0721
Onchocerca volvulus 0.0033 0.02 0.0408
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1053 0.1094
Brugia malayi cathepsin F-like cysteine proteinase 0.005 0.044 0.0457
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0229 0.2121
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0033 0.02 0.02
Trypanosoma cruzi calmodulin, putative 0.0033 0.02 0.0207
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0067 0.0671 0.0697
Echinococcus granulosus axis inhibition protein axin 0.0038 0.026 0.026
Echinococcus granulosus enteropeptidase 0.0023 0.0062 0.0062
Entamoeba histolytica cysteine proteinase, putative 0.0104 0.1197 0.4732
Leishmania major cathepsin L-like protease 0.0276 0.3601 1
Entamoeba histolytica hypothetical protein 0.0038 0.026 0.0288
Schistosoma mansoni hypothetical protein 0.0033 0.02 0.0207
Giardia lamblia Transglutaminase/protease, putative 0.0035 0.0224 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.2307 0.5929
Toxoplasma gondii preprocathepsin c precursor, putative 0.005 0.044 0.134
Toxoplasma gondii centrin, putative 0.0033 0.02 0.0608
Toxoplasma gondii histone deacetylase HDAC3 0.0067 0.0669 0.2038
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.1864
Echinococcus granulosus histone deacetylase 3 0.0067 0.0669 0.0669
Onchocerca volvulus 0.0148 0.1811 0.3706
Leishmania major calmodulin, putative 0.0033 0.02 0.0554
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0079 0.0848 0.0881
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0067 0.0671 0.0697
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0184 0.2307 0.2396
Echinococcus granulosus glycogen phosphorylase 0.0109 0.1257 0.1257
Echinococcus multilocularis Transglutaminase 0.0035 0.0224 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.2307 0.5929
Echinococcus granulosus calpain 5 0.0223 0.2855 0.2855
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.026 0.027
Giardia lamblia Cysteine protease 0.005 0.044 0.076
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0062 0.0064
Plasmodium vivax serine-repeat antigen (SERA) 0.005 0.044 0.1541
Onchocerca volvulus 0.0035 0.0229 0.0468
Trypanosoma cruzi conserved protein 0.0067 0.0671 0.0697
Giardia lamblia Encystation-specific protease 0.005 0.044 0.076
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0062 0.0599 0.1826
Schistosoma mansoni hypothetical protein 0.0023 0.0062 0.0064
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.005 0.044 0.1541
Echinococcus multilocularis histone deacetylase 1 0.0067 0.0669 0.0669
Loa Loa (eye worm) hypothetical protein 0.0023 0.0062 0.0064
Entamoeba histolytica cysteine proteinase, putative 0.0184 0.2307 1
Echinococcus granulosus calbindin 32 0.0034 0.0206 0.0206
Brugia malayi Papain family cysteine protease containing protein 0.005 0.044 0.0457
Trypanosoma cruzi histone deacetylase 1, putative 0.0067 0.0669 0.0695
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0104 0.1197 0.2806
Entamoeba histolytica cysteine protease, putative 0.005 0.044 0.114
Entamoeba histolytica cysteine protease, putative 0.005 0.044 0.114
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0104 0.1197 0.1243
Leishmania major calmodulin, putative 0.0033 0.02 0.0554
Loa Loa (eye worm) calmodulin-like protein 0.0033 0.02 0.0207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.2307 0.5929
Echinococcus granulosus calumenin 0.0034 0.0206 0.0206
Entamoeba histolytica glycogen phosphorylase, putative 0.0047 0.0392 0.0913
Onchocerca volvulus Cathepsin F homolog 0.0184 0.2307 0.4722
Giardia lamblia Cathepsin L precursor 0.005 0.044 0.076
Trypanosoma cruzi calmodulin, putative 0.0033 0.02 0.0207
Echinococcus multilocularis beta adrenergic receptor kinase 0.0038 0.0267 0.0267
Schistosoma mansoni Mername-AA248 (C02 family) 0.0223 0.2855 0.2964
Echinococcus multilocularis histone deacetylase 3 0.0067 0.0669 0.0669
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0062 0.0064
Brugia malayi Kringle domain containing protein 0.0039 0.0281 0.0292
Brugia malayi hypothetical protein 0.0038 0.026 0.027
Echinococcus multilocularis calpain A 0.0624 0.8481 0.8481
Echinococcus granulosus centrin 2 0.0033 0.02 0.02
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0023 0.0062 0.0062
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0587 0.061
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.005 0.044 0.1541
Loa Loa (eye worm) histone deacetylase 3 0.0067 0.0669 0.0695
Brugia malayi Cathepsin L-like precursor 0.0184 0.2307 0.2396
Onchocerca volvulus 0.0184 0.2307 0.4722
Leishmania major calpain family cysteine protease-like protein 0.0067 0.0671 0.1864
Schistosoma mansoni calmodulin 0.0033 0.02 0.0207
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0434 0.1323
Echinococcus multilocularis EF hand domain containing family member A2 0.0034 0.0206 0.0206
Echinococcus multilocularis neuronal calcium sensor 0.0033 0.02 0.02
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.044 0.0457
Echinococcus granulosus Glycosyl transferase family 35 0.0109 0.1257 0.1257
Trichomonas vaginalis glycogen phosphorylase, putative 0.0109 0.1257 0.2975
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.005 0.044 0.1541
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0038 0.027 0.0822
Echinococcus granulosus dnaJ subfamily B 0.04 0.5345 0.5345
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0067 0.0671 0.1864
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.0337 0.035
Echinococcus granulosus neurocalcin 0.0033 0.02 0.02
Giardia lamblia Cathepsin B precursor 0.005 0.044 0.076
Onchocerca volvulus Glycogen phosphorylase homolog 0.0109 0.1257 0.2573
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.044 0.0457
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0062 0.0064
Echinococcus granulosus Transglutaminase 0.0035 0.0224 0.0224
Schistosoma mansoni glycogen phosphorylase 0.0047 0.0392 0.0407
Echinococcus granulosus calcium uptake protein 1 0.0034 0.0206 0.0206
Mycobacterium ulcerans hypothetical protein 0.0035 0.0224 0.2067
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.026 0.026
Entamoeba histolytica cysteine protease, putative 0.0104 0.1197 0.4732
Loa Loa (eye worm) hypothetical protein 0.0038 0.026 0.027
Brugia malayi Protein kinase domain containing protein 0.0039 0.0281 0.0292
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.0697
Loa Loa (eye worm) hypothetical protein 0.0035 0.0229 0.0237
Mycobacterium ulcerans hypothetical protein 0.0035 0.0229 0.2121
Schistosoma mansoni calmodulin 0.0033 0.02 0.0207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.2307 0.5929
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0067 0.0671 0.0697
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.026 0.0171
Brugia malayi beta-lactamase family protein 0.0035 0.0229 0.0237
Plasmodium vivax unspecified product 0.0054 0.049 0.1717
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.005 0.044 0.0457
Echinococcus granulosus neuronal calcium sensor 0.0033 0.02 0.02
Giardia lamblia Cysteine protease 0.005 0.044 0.076
Leishmania major calmodulin-like protein 0.0033 0.02 0.0554
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0034 0.0206 0.0214
Echinococcus multilocularis tissue type plasminogen activator 0.0039 0.0281 0.0281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.013 0.155 0.38
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0184 0.2307 1
Schistosoma mansoni cathepsin C 0.005 0.044 0.0457
Echinococcus granulosus cathepsin L cysteine protease 0.0104 0.1197 0.1197
Schistosoma mansoni axis inhibition protein axin 0.0038 0.026 0.027
Trypanosoma brucei calpain-like protein, putative 0.0223 0.2855 0.7926
Leishmania major cathepsin L-like protease 0.0184 0.2307 0.6406
Plasmodium vivax unspecified product 0.0104 0.1197 0.4193
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0388 0.0403
Onchocerca volvulus 0.0048 0.0413 0.0846
Brugia malayi beta-lactamase 0.0035 0.0229 0.0237
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0062 0.0599 0.0599
Giardia lamblia Hypothetical protein 0.005 0.044 0.076
Entamoeba histolytica calpain family cysteine protease, putative 0.0067 0.0671 0.2239
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0229 0.0082
Entamoeba histolytica hypothetical protein 0.0038 0.026 0.0288
Giardia lamblia Hypothetical protein 0.005 0.044 0.076
Echinococcus multilocularis glycoprotein Antigen 5 0.0023 0.0062 0.0062
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0034 0.0206 0.0214
Trypanosoma cruzi cysteine proteinase, putative 0.0104 0.1197 0.1243
Loa Loa (eye worm) hypothetical protein 0.0038 0.026 0.027
Mycobacterium tuberculosis Conserved protein 0.0035 0.0229 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.3601 1
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.026 0.026
Mycobacterium ulcerans proteasome PrcB 0.0079 0.0848 1
Plasmodium vivax proteasome subunit beta type-2, putative 0.0038 0.027 0.0945
Toxoplasma gondii EF hand domain-containing protein 0.0033 0.02 0.0608
Leishmania major proteasome beta 5 subunit, putative 0.0079 0.0848 0.2354
Trypanosoma cruzi centrin, putative 0.0033 0.02 0.0207
Toxoplasma gondii proteasome subunit beta type, putative 0.0079 0.0848 0.2584
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0079 0.0848 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.3601 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0434 0.0451
Schistosoma mansoni cpg binding protein 0.003 0.015 0.0155
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0267 0.0277
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.1864
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0434 0.0434
Entamoeba histolytica cysteine proteinase, putative 0.0104 0.1197 0.4732
Loa Loa (eye worm) hypothetical protein 0.0037 0.0247 0.0257
Plasmodium falciparum serine repeat antigen 4 0.005 0.044 0.1906
Loa Loa (eye worm) hypothetical protein 0.0038 0.026 0.027
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0434 0.0451
Schistosoma mansoni glycogen phosphorylase 0.0109 0.1257 0.1306
Onchocerca volvulus 0.0039 0.0281 0.0575
Plasmodium falciparum centrin-1 0.0033 0.02 0.0865
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0079 0.0848 0.3076
Onchocerca volvulus Cathepsin L homolog 0.0184 0.2307 0.4722
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0253 0.3282 0.3408
Mycobacterium ulcerans hypothetical protein 0.0035 0.0224 0.2067
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0033 0.02 0.0207
Loa Loa (eye worm) hypothetical protein 0.0523 0.707 0.7342
Entamoeba histolytica cysteine protease, putative 0.0104 0.1197 0.4732
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.044 0.0457
Plasmodium vivax serine-repeat antigen (SERA) 0.005 0.044 0.1541
Brugia malayi calpain family protein 1 0.059 0.8008 0.8317
Brugia malayi Cytochrome P450 family protein 0.0043 0.0337 0.035
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0079 0.0848 0.1824
Echinococcus multilocularis calmodulin 0.0033 0.02 0.02
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0062 0.0599 0.1896
Trypanosoma brucei centrin-3 0.0033 0.02 0.0554
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0079 0.0848 0.2354
Plasmodium falciparum serine repeat antigen 3 0.005 0.044 0.1906
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0067 0.0671 0.0697
Leishmania major protein kinase, putative 0.0034 0.0206 0.0572
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0223 0.2855 0.7926
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.044 0.0676
Brugia malayi Papain family cysteine protease containing protein 0.0104 0.1197 0.1243
Schistosoma mansoni hypothetical protein 0.0329 0.4354 0.4521
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0434 0.066
Trypanosoma brucei calpain-like protein, putative 0.0223 0.2855 0.7926
Echinococcus granulosus beta-adrenergic receptor kinase 0.0038 0.0267 0.0267
Echinococcus granulosus cathepsin b 0.0705 0.9629 0.9629
Trichomonas vaginalis calpain, putative 0.0067 0.0671 0.1327
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0434 0.1206
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0062 0.0064
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.1864
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.3601 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0434 0.066
Echinococcus multilocularis neurocalcin 0.0033 0.02 0.02
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0047 0.0392 0.42
Echinococcus multilocularis proteasome (prosome, macropain) 0.0079 0.0848 0.0848
Echinococcus multilocularis calpain 7 (C02 family) 0.0223 0.2855 0.2855
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0558 0.1549
Echinococcus multilocularis calbindin 32 0.0034 0.0206 0.0206
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0434 0.1206
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0558 0.1247
Trichomonas vaginalis calpain, putative 0.0067 0.0671 0.1327
Brugia malayi programmed cell death protein 6 0.0033 0.02 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.026 0.0171
Leishmania major cathepsin L-like protease 0.0184 0.2307 0.6406
Leishmania major histone deacetylase, putative 0.0067 0.0669 0.1857
Brugia malayi calpain 5 0.0156 0.1916 0.199
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0038 0.027 0.0333
Trichomonas vaginalis calmodulin, putative 0.0034 0.0206 0.0018
Toxoplasma gondii cathepsin CPL 0.0184 0.2307 0.703
Trichomonas vaginalis glycogen phosphorylase, putative 0.0109 0.1257 0.2975
Entamoeba histolytica hypothetical protein 0.0043 0.0342 0.0678
Trypanosoma cruzi centrin, putative 0.0033 0.02 0.0207
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0229 0.2121
Giardia lamblia Cathepsin L-like protease 0.005 0.044 0.076
Leishmania major hypothetical protein, conserved 0.0039 0.0281 0.078
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0038 0.026 0.027
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0062 0.0599 0.0622
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0067 0.0671 0.0697
Loa Loa (eye worm) hypothetical protein 0.0023 0.0062 0.0064
Trypanosoma cruzi cysteine peptidase, putative 0.0184 0.2307 0.2396
Brugia malayi Papain family cysteine protease containing protein 0.0184 0.2307 0.2396
Schistosoma mansoni histone deacetylase 0.0067 0.0669 0.0695
Loa Loa (eye worm) glycogen phosphorylase 0.0109 0.1257 0.1306
Schistosoma mansoni hypothetical protein 0.0033 0.02 0.0207
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.0697
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0229 0.0237
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0067 0.0671 0.0697
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.044 0.0457
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.044 0.0676
Echinococcus multilocularis programmed cell death protein 0.0033 0.02 0.02
Entamoeba histolytica cysteine protease, putative 0.005 0.044 0.114
Leishmania major cathepsin L-like protease 0.0184 0.2307 0.6406
Echinococcus multilocularis cathepsin b 0.0705 0.9629 0.9629
Loa Loa (eye worm) hypothetical protein 0.005 0.044 0.0457
Loa Loa (eye worm) hypothetical protein 0.0067 0.0669 0.0695
Echinococcus granulosus cathepsin L 0.005 0.044 0.044
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0038 0.0267 0.0277
Entamoeba histolytica cysteine protease, putative 0.0104 0.1197 0.4732
Leishmania major hypothetical protein, conserved 0.0035 0.0229 0.0635
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0104 0.1197 0.1243
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0281 0.0292
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0558 0.0579
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0023 0.0062 0.0062
Giardia lamblia Cathepsin L precursor 0.005 0.044 0.076
Giardia lamblia Cathepsin L precursor 0.005 0.044 0.076
Brugia malayi Pre-SET motif family protein 0.0252 0.3267 0.3393
Loa Loa (eye worm) programmed cell death protein 6 0.0034 0.0206 0.0214
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0079 0.0848 0.0881
Brugia malayi cahepsin L-like non-peptiedase homolog 0.005 0.044 0.0457
Entamoeba histolytica cysteine protease, putative 0.0104 0.1197 0.4732
Plasmodium vivax calpain, putative 0.0223 0.2855 1
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0223 0.2855 0.2964
Giardia lamblia Hypothetical protein 0.0035 0.0224 0.0059
Brugia malayi Pre-SET motif family protein 0.0037 0.0247 0.0257
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0038 0.027 0.027
Brugia malayi proteasome subunit beta type 2 0.0038 0.027 0.028
Loa Loa (eye worm) hypothetical protein 0.0067 0.0671 0.0697
Trypanosoma brucei calmodulin, putative 0.0033 0.02 0.0554
Schistosoma mansoni hypothetical protein 0.0047 0.0388 0.0403
Schistosoma mansoni calpain-7 (C02 family) 0.0223 0.2855 0.2964
Brugia malayi EF hand family protein 0.0034 0.0206 0.0214
Giardia lamblia Dipeptidyl-peptidase I precursor 0.005 0.044 0.076
Schistosoma mansoni cathepsin B (C01 family) 0.005 0.044 0.0457
Entamoeba histolytica cysteine proteinase, putative 0.0104 0.1197 0.4732
Leishmania major cathepsin L-like protease 0.0276 0.3601 1
Trichomonas vaginalis esterase, putative 0.0035 0.0229 0.0082
Trypanosoma brucei calpain-like protein, putative 0.0223 0.2855 0.7926
Trichomonas vaginalis hypothetical protein 0.0067 0.0671 0.1327
Mycobacterium tuberculosis Conserved protein 0.0035 0.0229 0.0016
Schistosoma mansoni regulator of G protein signaling 0.0038 0.026 0.027
Trypanosoma brucei cysteine peptidase C (CPC) 0.0253 0.3282 0.9113
Schistosoma mansoni cathepsin s 0.0054 0.049 0.0509
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0067 0.0671 0.1327
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0184 0.2307 0.2307
Loa Loa (eye worm) calpain family protein 1 0.0434 0.5825 0.6049
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0223 0.2855 0.2964
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0062 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0229 0.0237
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0229 0.0016
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0079 0.0848 0.0881
Toxoplasma gondii kringle domain-containing protein 0.0039 0.0281 0.0856
Trypanosoma brucei calpain-like protein, putative 0.0223 0.2855 0.7926
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0038 0.027 0.028
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.044 0.0457
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.3601 1
Echinococcus multilocularis cathepsin L 0.0104 0.1197 0.1197
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.1864
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0104 0.1197 0.1243
Brugia malayi cathepsin F-like cysteine proteinase 0.0054 0.049 0.0509
Schistosoma mansoni calpain (C02 family) 0.0223 0.2855 0.2964
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0223 0.2855 0.2964
Loa Loa (eye worm) hypothetical protein 0.0184 0.2307 0.2396
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0342 0.0342
Echinococcus granulosus transmembrane protease serine 3 0.0023 0.0062 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.2307 0.5929
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.005 0.044 0.0457
Loa Loa (eye worm) cathepsin B 0.0253 0.3282 0.3408
Schistosoma mansoni calpain-7 (C02 family) 0.0223 0.2855 0.2964
Entamoeba histolytica glycogenphosphorylase, putative 0.0047 0.0392 0.0913
Onchocerca volvulus 0.0023 0.0062 0.0127
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0184 0.2307 0.5929
Brugia malayi EF hand family protein 0.0033 0.02 0.0207
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0127 0.0132
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0184 0.2307 0.2396
Trypanosoma brucei Calpain-like protein CALP1.3 0.0067 0.0671 0.1864
Loa Loa (eye worm) hypothetical protein 0.013 0.155 0.161
Loa Loa (eye worm) histone deacetylase 1 0.0067 0.0669 0.0695
Giardia lamblia Cathepsin L precursor 0.005 0.044 0.076
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0558 0.6311
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.005 0.044 0.0457
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0247 0.0257
Giardia lamblia Cathepsin B precursor 0.005 0.044 0.076
Toxoplasma gondii cathepsin B 0.0253 0.3282 1
Trypanosoma brucei Calpain-like protein 1.2 0.0067 0.0671 0.1864
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0434 0.1206
Brugia malayi CXXC zinc finger family protein 0.0028 0.0127 0.0132
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0223 0.2855 0.2964
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0097
Echinococcus granulosus axis inhibition protein axin 0.0038 0.026 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.044 0.0676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.044 0.0676
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0247 0.0247
Echinococcus multilocularis geminin 0.0329 0.4354 0.4354
Echinococcus multilocularis microtubule associated protein 2 0.0677 0.9224 0.9224
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0067 0.0669 0.1321
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0434 0.0451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.2307 0.5929
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0229 0.0237
Echinococcus multilocularis cathepsin L cysteine protease 0.0184 0.2307 0.2307
Echinococcus multilocularis cathepsin L 0.005 0.044 0.044
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.0697
Loa Loa (eye worm) hypothetical protein 0.005 0.044 0.0457
Trypanosoma cruzi major cysteine proteinase, putative 0.0143 0.1734 0.1801
Giardia lamblia Cathepsin L-like protease 0.005 0.044 0.076
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.2946 0.2946
Brugia malayi cathepsin Z-like cysteine proteinase 0.005 0.044 0.0457
Plasmodium falciparum calpain 0.0067 0.0671 0.291
Trichomonas vaginalis peptide N-glycanase, putative 0.0035 0.0224 0.007
Echinococcus multilocularis cysteine protease 0.0184 0.2307 0.2307
Onchocerca volvulus 0.0035 0.0229 0.0468
Trypanosoma brucei kinesin, putative 0.0156 0.1916 0.532
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0229 0.0016
Schistosoma mansoni hypothetical protein 0.04 0.5345 0.5551
Loa Loa (eye worm) fibroinase 0.0184 0.2307 0.2396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.3601 1
Echinococcus granulosus proteasome prosome macropain 0.0079 0.0848 0.0848
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0184 0.2307 0.5929
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.1864
Trichomonas vaginalis calcineurin B subunit, putative 0.0034 0.0206 0.0018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.044 0.0676
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0067 0.0669 0.1321
Brugia malayi Trypsin-like protease protein 5 0.0023 0.0062 0.0064
Schistosoma mansoni axis inhibition protein axin 0.0038 0.026 0.027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0104 0.1197 0.2806
Toxoplasma gondii ABC1 family protein 0.0035 0.0229 0.0696
Brugia malayi A-kinase anchor protein 10, precursor 0.0038 0.026 0.027
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0229 0.0082
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0038 0.027 0.028
Entamoeba histolytica papain family cysteine protease domain containing protein 0.005 0.044 0.114
Echinococcus multilocularis calpain family protein 1, d 0.0434 0.5825 0.5825
Schistosoma mansoni cpg binding protein 0.0028 0.0127 0.0132
Schistosoma mansoni hypothetical protein 0.0023 0.0062 0.0064
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0062 0.0064
Schistosoma mansoni regulator of G protein signaling 0.0038 0.026 0.027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0247 0.0257
Plasmodium falciparum serine repeat antigen 5 0.005 0.044 0.1906
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0229 0.0082
Entamoeba histolytica hypothetical protein 0.005 0.044 0.114
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.044 0.0676
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0223 0.2855 0.2964
Onchocerca volvulus 0.0047 0.0388 0.0795
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.02 0.0554
Schistosoma mansoni regulator of G protein signaling 0.0038 0.026 0.027
Leishmania major cathepsin L-like protease 0.0276 0.3601 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0184 0.2307 0.5929
Loa Loa (eye worm) hypothetical protein 0.0054 0.049 0.0509
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0062 0.0064
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0079 0.0848 0.2332
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.0697
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1053 0.1053
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0067 0.0671 0.2046
Toxoplasma gondii cathepsin CPC1 0.005 0.044 0.134
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0062 0.0064
Trypanosoma brucei Calpain-like protein 1.1 0.0067 0.0671 0.1864
Entamoeba histolytica cysteine proteinase 1, putative 0.0104 0.1197 0.4732
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0223 0.2855 0.2964
Trypanosoma cruzi cysteine peptidase, putative 0.0276 0.3601 0.374
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0223 0.2855 0.2964
Trypanosoma cruzi kinesin, putative 0.0156 0.1916 0.199
Echinococcus multilocularis regulator of G protein signaling 0.0038 0.026 0.026
Leishmania major i/6 autoantigen-like protein 0.0033 0.02 0.0554
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0623 0.8475 0.8475
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0623 0.8475 0.8801
Onchocerca volvulus 0.0184 0.2307 0.4722
Giardia lamblia Dipeptidyl-peptidase I precursor 0.005 0.044 0.076
Toxoplasma gondii histone deacetylase HDAC2 0.0067 0.0669 0.2038
Brugia malayi histone deacetylase 1 (HD1) 0.0067 0.0669 0.0695
Schistosoma mansoni survival motor neuron protein 0.0047 0.0388 0.0403
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0038 0.0267 0.0277
Echinococcus granulosus glycoprotein Antigen 5 0.0023 0.0062 0.0062
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.026 0.026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.3601 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1053 0.1094
Plasmodium vivax vivapain-2 0.0184 0.2307 0.8083
Brugia malayi regulator of G-protein signaling rgs-7 0.0038 0.026 0.027
Plasmodium vivax centrin-1, putative 0.0033 0.02 0.0699
Trypanosoma brucei cysteine peptidase, putative 0.0067 0.0671 0.1864
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.044 0.0676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.044 0.0676
Loa Loa (eye worm) cysteine protease 0.0184 0.2307 0.2396
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0067 0.0671 0.1327
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0184 0.2307 0.5929
Entamoeba histolytica cysteine proteinase 2 0.0104 0.1197 0.4732
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0342 0.0356
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.0337 0.035
Giardia lamblia Cathepsin B precursor 0.0253 0.3282 1
Trypanosoma brucei calpain, putative 0.0067 0.0671 0.1864
Brugia malayi MAP kinase sur-1 0.005 0.0434 0.0451
Plasmodium vivax vivapain-2 0.0184 0.2307 0.8083
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0038 0.027 0.0197
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.026 0.027
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0062 0.0064
Echinococcus multilocularis cysteine protease 0.0184 0.2307 0.2307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.3601 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0062 0.0064
Onchocerca volvulus 0.0367 0.4887 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0067 0.0671 0.0697
Brugia malayi Cathepsin L-like precursor 0.0184 0.2307 0.2396
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0047 0.0392 0.0627
Echinococcus granulosus calpain 0.0223 0.2855 0.2855
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.005 0.044 0.0676
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0033 0.02 0.02
Echinococcus granulosus cathepsin l1 0.013 0.155 0.155
Schistosoma mansoni microtubule-associated protein tau 0.0677 0.9224 0.9579
Brugia malayi Trypsin family protein 0.0023 0.0062 0.0064
Schistosoma mansoni hypothetical protein 0.0039 0.0281 0.0292
Loa Loa (eye worm) hypothetical protein 0.0038 0.026 0.027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0062 0.0064
Trypanosoma brucei centrin, putative 0.0033 0.02 0.0554
Entamoeba histolytica papain family cysteine protease domain containing protein 0.005 0.044 0.114
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.005 0.044 0.1541
Onchocerca volvulus 0.0023 0.0062 0.0127
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0038 0.026 0.026
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0062 0.0062
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0558 0.6311
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0247 0.0257
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0038 0.026 0.0171
Leishmania major cytochrome p450-like protein 0.0043 0.0337 0.0935
Schistosoma mansoni regulator of G protein signaling 0.0038 0.026 0.027
Brugia malayi Cathepsin L-like precursor 0.0184 0.2307 0.2396
Schistosoma mansoni reticulocalbin 0.0034 0.0206 0.0214
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0705 0.9629 1
Leishmania major kinesin, putative 0.0156 0.1916 0.532
Chlamydia trachomatis glycogen phosphorylase 0.0109 0.1257 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0253 0.3282 0.8671
Plasmodium vivax vivapain-1 0.0104 0.1197 0.4193
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.005 0.044 0.0676
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.0337 0.035
Schistosoma mansoni cpg binding protein 0.003 0.015 0.0155
Trypanosoma cruzi I/6 autoantigen, putative 0.0033 0.02 0.0207
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.026 0.027
Echinococcus multilocularis dnaJ subfamily B 0.04 0.5345 0.5345
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0038 0.027 0.027
Giardia lamblia Glycogen phosphorylase 0.0109 0.1257 0.3417
Leishmania major proteasome beta 2 subunit, putative 0.0038 0.027 0.0749
Onchocerca volvulus 0.0184 0.2307 0.4722
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0062 0.0599 0.0622
Loa Loa (eye worm) hypothetical protein 0.0035 0.0229 0.0237
Brugia malayi Papain family cysteine protease containing protein 0.0104 0.1197 0.1243
Trypanosoma cruzi cysteine proteinase, putative 0.0104 0.1197 0.1243
Echinococcus multilocularis programmed cell death protein 0.0033 0.02 0.02
Echinococcus multilocularis hypothetical protein 0.0223 0.2855 0.2855
Trypanosoma brucei Component of motile flagella 41 0.0033 0.02 0.0554
Leishmania major programmed cell death 6 protein-like protein 0.0033 0.02 0.0554
Plasmodium falciparum serine repeat antigen 6 0.005 0.044 0.1906
Plasmodium vivax proteasome subunit beta type-1, putative 0.0062 0.0599 0.2099
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0033 0.02 0.02
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0229 0.0229
Echinococcus multilocularis transmembrane protease serine 3 0.0023 0.0062 0.0062
Onchocerca volvulus 0.0023 0.0062 0.0127
Trypanosoma brucei Calpain-like protein 2 0.0067 0.0671 0.1864
Loa Loa (eye worm) hypothetical protein 0.0367 0.4887 0.5075
Loa Loa (eye worm) hypothetical protein 0.0035 0.0229 0.0237
Loa Loa (eye worm) hypothetical protein 0.0054 0.049 0.0509
Trichomonas vaginalis conserved hypothetical protein 0.005 0.044 0.0676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.044 0.0676
Loa Loa (eye worm) hypothetical protein 0.013 0.155 0.161
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0038 0.027 0.0749
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.2307 0.5929
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0184 0.2307 1
Giardia lamblia Cysteine protease 0.005 0.044 0.076
Loa Loa (eye worm) hypothetical protein 0.0705 0.9629 1
Brugia malayi Trypsin family protein 0.0023 0.0062 0.0064
Plasmodium falciparum serine repeat antigen 1 0.005 0.044 0.1906
Trichomonas vaginalis histone deacetylase, putative 0.0067 0.0669 0.1321
Leishmania major phospholipase c-like protein 0.0033 0.02 0.0554
Schistosoma mansoni cathepsin F (C01 family) 0.013 0.155 0.161
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0558 0.0558
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.3601 1
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0434 0.0434
Entamoeba histolytica cysteine protease, putative 0.005 0.044 0.114
Brugia malayi fibroinase precursor 0.005 0.044 0.0457
Loa Loa (eye worm) hypothetical protein 0.0434 0.5825 0.6049
Toxoplasma gondii histone deacetylase HDAC5 0.0019 0.0003 0.001
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0223 0.2855 0.2964
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0501 0.052
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.026 0.0171
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0067 0.0671 0.0697
Loa Loa (eye worm) trypsin family protein 0.0023 0.0062 0.0064
Trypanosoma cruzi caltractin, putative 0.0033 0.02 0.0207
Trypanosoma brucei proteasome beta 6 subunit 0.0062 0.0599 0.1664
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0229 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0184 0.2307 0.5929
Loa Loa (eye worm) hypothetical protein 0.0023 0.0062 0.0064
Echinococcus granulosus programmed cell death protein 0.0033 0.02 0.02
Schistosoma mansoni mitochondrial solute carrier 0.0033 0.02 0.0207
Onchocerca volvulus 0.0184 0.2307 0.4722
Loa Loa (eye worm) calpain 0.0223 0.2855 0.2964
Giardia lamblia Cathepsin B precursor 0.005 0.044 0.076
Leishmania major hypothetical protein, unknown function 0.0067 0.0671 0.1864
Echinococcus granulosus cathepsin l cysteine peptidase 0.0184 0.2307 0.2307
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0558 0.6311
Brugia malayi Thioredoxin family protein 0.0035 0.0224 0.0233
Entamoeba histolytica cysteine protease, putative 0.0104 0.1197 0.4732
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.026 0.026
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.1864
Entamoeba histolytica hypothetical protein 0.0043 0.0342 0.0678
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.1864
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.026 0.0171
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0034 0.0206 0.0572
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.044 0.0457
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.026 0.027
Echinococcus multilocularis calpain 0.0223 0.2855 0.2855
Loa Loa (eye worm) hypothetical protein 0.0035 0.0229 0.0237
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1053 0.1053
Echinococcus multilocularis centrin 2 0.0033 0.02 0.02
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.2946 0.2946
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.005 0.044 0.1541
Entamoeba histolytica hypothetical protein, conserved 0.0034 0.0206 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0184 0.2307 0.5929
Entamoeba histolytica cysteine protease, putative 0.0104 0.1197 0.4732
Brugia malayi Cathepsin L-like cysteine proteinase 0.013 0.155 0.161
Plasmodium falciparum serine repeat antigen 9 0.005 0.044 0.1906
Entamoeba histolytica cysteine proteinase, putative 0.0184 0.2307 1
Schistosoma mansoni rab 0.0033 0.02 0.0207
Loa Loa (eye worm) proteasome subunit beta type 2 0.0038 0.027 0.028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0184 0.2307 0.5929
Onchocerca volvulus 0.0184 0.2307 0.4722
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0079 0.0848 0.0881
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.013 0.155 0.161
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0229 0.0229
Entamoeba histolytica cysteine protease, putative 0.0104 0.1197 0.4732
Mycobacterium ulcerans transglutaminase family protein 0.0035 0.0224 0.2067
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0434 0.0434
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0229 0.0237
Trypanosoma cruzi centrin-3 0.0033 0.02 0.0207
Schistosoma mansoni calmodulin related calcium binding protein 0.0033 0.02 0.0207
Trypanosoma brucei centrin, putative 0.0033 0.02 0.0554
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.0337 0.035
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0434 0.0451
Trichomonas vaginalis calpain, putative 0.0067 0.0671 0.1327
Toxoplasma gondii hypothetical protein 0.0067 0.0671 0.2046
Trichomonas vaginalis histone deacetylase, putative 0.0067 0.0669 0.1321
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0033 0.02 0.0207
Echinococcus multilocularis glycogen phosphorylase 0.0109 0.1257 0.1257
Loa Loa (eye worm) ctsf protein 0.0184 0.2307 0.2396
Echinococcus granulosus EF HAND 1 calcium binding site 0.0033 0.02 0.02
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0062 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0184 0.2307 0.5929
Brugia malayi PXA domain containing protein 0.0038 0.026 0.027
Onchocerca volvulus 0.013 0.155 0.3172
Schistosoma mansoni neuronal calcium sensor 0.0033 0.02 0.0207
Brugia malayi hypothetical protein 0.0043 0.0342 0.0356
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0062 0.0064
Loa Loa (eye worm) hypothetical protein 0.0035 0.0229 0.0237
Plasmodium vivax serine-repeat antigen (SERA), putative 0.005 0.044 0.1541
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1053 0.1094
Echinococcus multilocularis Mastin 0.0023 0.0062 0.0062
Plasmodium vivax vivapain-3 0.0104 0.1197 0.4193
Brugia malayi histone deacetylase 3 (HD3) 0.0067 0.0669 0.0695
Echinococcus granulosus cathepsin b 0.0705 0.9629 0.9629
Loa Loa (eye worm) hypothetical protein 0.0229 0.2946 0.3059
Schistosoma mansoni cathepsin S (C01 family) 0.005 0.044 0.0457
Brugia malayi beta-lactamase family protein 0.0035 0.0229 0.0237
Loa Loa (eye worm) RGS-3 protein 0.0038 0.026 0.027
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0033 0.02 0.0207
Entamoeba histolytica cysteine protease, putative 0.0104 0.1197 0.4732
Echinococcus granulosus cysteine protease 0.0104 0.1197 0.1197
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0498 0.1518
Loa Loa (eye worm) TK/ROR protein kinase 0.0039 0.0281 0.0292
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.026 0.027
Loa Loa (eye worm) hypothetical protein 0.005 0.044 0.0457
Toxoplasma gondii cathepsin CPC2 0.005 0.044 0.134
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.026 0.026
Schistosoma mansoni calpain-2 (C02 family) 0.0067 0.0671 0.0697
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0671 0.1864
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.026 0.026
Trichomonas vaginalis histone deacetylase, putative 0.0067 0.0669 0.1321
Entamoeba histolytica hypothetical protein 0.0043 0.0342 0.0678
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0705 0.9629 1
Plasmodium falciparum histone deacetylase 1 0.0067 0.0669 0.2899
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.005 0.044 0.0676
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.3601 1
Trypanosoma brucei protein kinase, putative 0.005 0.0434 0.1206
Giardia lamblia Histone deacetylase 0.0067 0.0669 0.1505
Echinococcus multilocularis tumor protein p63 0.0331 0.438 0.438
Onchocerca volvulus 0.0028 0.0127 0.026
Trichomonas vaginalis histone deacetylase, putative 0.0067 0.0669 0.1321
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0067 0.0671 0.0697
Loa Loa (eye worm) PXA domain-containing protein 0.0038 0.026 0.027
Entamoeba histolytica cysteine protease, putative 0.0104 0.1197 0.4732
Giardia lamblia Dipeptidyl-peptidase I precursor 0.005 0.044 0.076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.2307 0.5929
Trypanosoma cruzi histone deacetylase 1, putative 0.0067 0.0669 0.0695
Loa Loa (eye worm) hypothetical protein 0.005 0.044 0.0457
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0705 0.9629 1
Brugia malayi Cathepsin L-like precursor 0.013 0.155 0.161
Entamoeba histolytica cysteine protease, putative 0.0104 0.1197 0.4732
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0067 0.0671 0.0697
Leishmania major hypothetical protein, conserved 0.0067 0.0671 0.1864
Schistosoma mansoni memapsin-2 (A01 family) 0.0422 0.5652 0.587
Schistosoma mansoni centrin 0.0033 0.02 0.0207
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.044 0.0676
Echinococcus multilocularis cpg binding protein 0.003 0.015 0.015
Plasmodium vivax serine-repeat antigen (SERA), putative 0.005 0.044 0.1541
Entamoeba histolytica cysteine proteinase, putative 0.0104 0.1197 0.4732
Trichomonas vaginalis histone deacetylase, putative 0.0067 0.0669 0.1321
Entamoeba histolytica calpain large subunit domain III containing protein 0.0156 0.1916 0.8144
Giardia lamblia Cathepsin B precursor 0.005 0.044 0.076
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0705 0.9629 1
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.026 0.027
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0062 0.0064
Schistosoma mansoni hypothetical protein 0.0035 0.0224 0.0233
Leishmania major hypothetical protein, conserved 0.0033 0.02 0.0554
Loa Loa (eye worm) hypothetical protein 0.0023 0.0062 0.0064
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.049 0.0509
Loa Loa (eye worm) hypothetical protein 0.059 0.8008 0.8317
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0229 0.0635
Plasmodium falciparum cysteine repeat modular protein 1 0.0039 0.0281 0.1218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.044 0.0676
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0067 0.0671 0.1327
Entamoeba histolytica cysteine protease, putative 0.0104 0.1197 0.4732
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0223 0.2855 0.7926
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.044 0.0676
Loa Loa (eye worm) hypothetical protein 0.0048 0.0413 0.0429
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0267 0.0277

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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