Detailed information for compound 1576608

Basic information

Technical information
  • TDR Targets ID: 1576608
  • Name: 5-[1-(3-hydroxypropylamino)ethylidene]-1,3-di azinane-2,4,6-trione
  • MW: 227.217 | Formula: C9H13N3O4
  • H donors: 4 H acceptors: 4 LogP: -0.3 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCCNC(=C1C(=O)NC(=O)NC1=O)C
  • InChi: 1S/C9H13N3O4/c1-5(10-3-2-4-13)6-7(14)11-9(16)12-8(6)15/h10,13H,2-4H2,1H3,(H2,11,12,14,15,16)
  • InChiKey: CLIQGOWGELUMNY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[1-(3-hydroxypropylamino)ethylidene]hexahydropyrimidine-2,4,6-trione
  • 5-[1-(3-hydroxypropylamino)ethylidene]barbituric acid
  • 5-[1-(3-Hydroxy-propylamino)-ethylidene]-pyrimidine-2,4,6-trione
  • MLS000762491
  • STOCK4S-00926
  • SMR000438009

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi centrin, putative 0.0047 0.012 0.0075
Plasmodium vivax serine-repeat antigen (SERA) 0.012 0.0586 0.2049
Echinococcus granulosus cathepsin L cysteine protease 0.0253 0.1437 0.1398
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0098 0.0153
Giardia lamblia Cathepsin B precursor 0.012 0.0586 0.1421
Trichomonas vaginalis calcium binding protein, putative 0.0044 0.0098 0.0153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.2685 0.7647
Plasmodium vivax serine-repeat antigen (SERA) 0.012 0.0586 0.2049
Trypanosoma cruzi centrin-3 0.0047 0.012 0.0075
Schistosoma mansoni neuronal calcium sensor 0.0044 0.0098 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.2685 0.7647
Loa Loa (eye worm) hypothetical protein 0.0449 0.2685 0.2685
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0242 0.1363 0.1324
Brugia malayi EF hand family protein 0.0044 0.0098 0.0053
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0204
Entamoeba histolytica cysteine protease, putative 0.0253 0.1437 0.5176
Loa Loa (eye worm) hypothetical protein 0.0315 0.1834 0.1834
Loa Loa (eye worm) hypothetical protein 0.0044 0.0098 0.0098
Trypanosoma cruzi calmodulin, putative 0.0044 0.0098 0.0053
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0588
Onchocerca volvulus 0.0412 0.2452 0.9116
Schistosoma mansoni calpain-7 (C02 family) 0.0242 0.1363 0.1324
Entamoeba histolytica cysteine protease, putative 0.0253 0.1437 0.5176
Brugia malayi cathepsin F-like cysteine proteinase 0.012 0.0586 0.0543
Brugia malayi Cathepsin L-like precursor 0.0315 0.1834 0.1797
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.2685 0.7647
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0067 0.0248 0.0204
Brugia malayi calpain 5 0.0067 0.0248 0.0204
Toxoplasma gondii calcium-dependent protein kinase 0.0044 0.0104 0.017
Plasmodium vivax vivapain-2 0.0449 0.2685 1
Echinococcus granulosus cysteine protease 0.0253 0.1437 0.1398
Entamoeba histolytica cysteine protease, putative 0.012 0.0586 0.1887
Brugia malayi calpain 7 0.0242 0.1363 0.1324
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0204
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0067 0.0248 0.0204
Trypanosoma brucei calpain, putative 0.0067 0.0248 0.0588
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0697 0.4273 0.4247
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0242 0.1363 0.1324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0315 0.1834 0.5182
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0242 0.1363 0.1324
Brugia malayi gamma-secretase subunit aph-1 0.0249 0.1412 0.1373
Echinococcus granulosus neurocalcin 0.0044 0.0098 0.0053
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.012 0.0586 0.0543
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0242 0.1363 0.3817
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.2685 0.7647
Brugia malayi fibroinase precursor 0.012 0.0586 0.0543
Onchocerca volvulus 0.0449 0.2685 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0204
Loa Loa (eye worm) calpain 0.0242 0.1363 0.1363
Brugia malayi Papain family cysteine protease containing protein 0.012 0.0586 0.0543
Giardia lamblia Cathepsin B precursor 0.0576 0.3498 1
Entamoeba histolytica cysteine protease, putative 0.0253 0.1437 0.5176
Brugia malayi cathepsin Z-like cysteine proteinase 0.012 0.0586 0.0543
Plasmodium falciparum serine repeat antigen 4 0.012 0.0586 0.1887
Echinococcus granulosus cathepsin b 0.1594 1 1
Schistosoma mansoni calpain-7 (C02 family) 0.0242 0.1363 0.1324
Echinococcus granulosus calumenin 0.0044 0.0104 0.0059
Echinococcus granulosus programmed cell death protein 0.0047 0.012 0.0075
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0045
Brugia malayi cahepsin L-like non-peptiedase homolog 0.012 0.0586 0.0543
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0588
Echinococcus granulosus cathepsin l cysteine peptidase 0.0449 0.2685 0.2652
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0588
Echinococcus granulosus centrin 2 0.0044 0.0098 0.0053
Echinococcus multilocularis hypothetical protein 0.0242 0.1363 0.1324
Trypanosoma cruzi caltractin, putative 0.0044 0.0098 0.0053
Echinococcus granulosus neuronal calcium sensor 0.0044 0.0098 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.2685 0.7647
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0449 0.2685 0.2685
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0588
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.2685 0.7647
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.012 0.0586 0.2049
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.012 0.0586 0.2049
Trypanosoma brucei Aph-1 protein, putative 0.0097 0.044 0.1145
Leishmania major hypothetical protein, conserved 0.0044 0.0104 0.017
Entamoeba histolytica cysteine protease, putative 0.0253 0.1437 0.5176
Schistosoma mansoni mitochondrial solute carrier 0.0044 0.0098 0.0053
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0067 0.0248 0.0204
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.1437 0.4032
Onchocerca volvulus 0.0449 0.2685 1
Entamoeba histolytica cysteine proteinase 2 0.0253 0.1437 0.5176
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.012 0.0586 0.1567
Loa Loa (eye worm) beta-lactamase 0.0035 0.0045 0.0045
Schistosoma mansoni cathepsin F (C01 family) 0.0449 0.2685 0.2652
Trypanosoma cruzi centrin, putative 0.0047 0.012 0.0075
Entamoeba histolytica calpain family cysteine protease, putative 0.0067 0.0248 0.0581
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.2685 0.7647
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0242 0.1363 0.1324
Brugia malayi calpain family protein 1 0.0654 0.3995 0.3968
Entamoeba histolytica calpain large subunit domain III containing protein 0.0175 0.0935 0.3235
Loa Loa (eye worm) hypothetical protein 0.012 0.0586 0.0586
Entamoeba histolytica grainin 2 0.0047 0.012 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.2685 0.7647
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.1437 0.5176
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0044 0.0104 0.0059
Loa Loa (eye worm) hypothetical protein 0.0315 0.1834 0.1834
Trypanosoma brucei Component of motile flagella 41 0.0044 0.0098 0.0153
Schistosoma mansoni neuronal calcium sensor 0.0044 0.0098 0.0053
Brugia malayi Cathepsin L-like precursor 0.0449 0.2685 0.2652
Trichomonas vaginalis calcineurin B subunit, putative 0.0044 0.0098 0.0153
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0586 0.1567
Entamoeba histolytica cysteine proteinase, putative 0.0449 0.2685 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.1259 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.012 0.0586 0.0586
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0242 0.1363 0.3817
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.012 0.0586 0.1567
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.012 0.0586 0.1567
Loa Loa (eye worm) hypothetical protein 0.1594 1 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0588
Brugia malayi Papain family cysteine protease containing protein 0.0449 0.2685 0.2652
Leishmania major centrin, putative 0.0044 0.0098 0.0153
Trypanosoma brucei cysteine peptidase C (CPC) 0.0576 0.3498 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0253 0.1437 0.1398
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0248 0.0588
Giardia lamblia Cathepsin B precursor 0.0576 0.3498 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.2685 0.7647
Brugia malayi Papain family cysteine protease containing protein 0.012 0.0586 0.0543
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0449 0.2685 1
Echinococcus multilocularis calmodulin 0.0044 0.0098 0.0053
Entamoeba histolytica cysteine protease, putative 0.0253 0.1437 0.5176
Plasmodium vivax unspecified product 0.012 0.0586 0.2049
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.012 0.0586 0.2049
Giardia lamblia Cathepsin L precursor 0.012 0.0586 0.1421
Giardia lamblia Cathepsin L precursor 0.012 0.0586 0.1421
Giardia lamblia Encystation-specific protease 0.012 0.0586 0.1421
Leishmania major kinesin, putative 0.0175 0.0935 0.2577
Giardia lamblia Cathepsin B precursor 0.012 0.0586 0.1421
Trypanosoma cruzi cruzipain precursor, putative 0.0133 0.0671 0.0629
Giardia lamblia Dipeptidyl-peptidase I precursor 0.012 0.0586 0.1421
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0588
Trichomonas vaginalis calcium binding protein, putative 0.0044 0.0098 0.0153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.2685 0.7647
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0067 0.0248 0.0588
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0133 0.0671 0.0671
Leishmania major calcineurin B subunit, putative 0.0044 0.0098 0.0153
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.012 0.0586 0.0543
Brugia malayi calcium-binding protein 0.0044 0.0098 0.0053
Loa Loa (eye worm) hypothetical protein 0.012 0.0586 0.0586
Loa Loa (eye worm) hypothetical protein 0.012 0.0586 0.0586
Schistosoma mansoni centrin 0.0044 0.0098 0.0053
Toxoplasma gondii centrin 0.0044 0.0098 0.0153
Trichomonas vaginalis centrin, putative 0.0044 0.0098 0.0153
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0242 0.1363 0.1324
Plasmodium vivax unspecified product 0.0133 0.0671 0.237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.2685 0.7647
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.012 0.0586 0.1567
Entamoeba histolytica cysteine protease, putative 0.012 0.0586 0.1887
Trypanosoma cruzi cysteine peptidase, putative 0.0449 0.2685 0.2652
Giardia lamblia Cathepsin L precursor 0.012 0.0586 0.1421
Giardia lamblia Dipeptidyl-peptidase I precursor 0.012 0.0586 0.1421
Loa Loa (eye worm) calpain D 0.0067 0.0248 0.0248
Entamoeba histolytica cysteine protease, putative 0.012 0.0586 0.1887
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0044 0.0098 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.2685 0.7647
Entamoeba histolytica cysteine proteinase, putative 0.0449 0.2685 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0067 0.0248 0.0204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0586 0.1567
Schistosoma mansoni hypothetical protein 0.0044 0.0098 0.0053
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1594 1 1
Schistosoma mansoni reticulocalbin 0.0044 0.0098 0.0053
Onchocerca volvulus Cathepsin L homolog 0.0449 0.2685 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.012 0.0586 0.2049
Toxoplasma gondii cathepsin CPC1 0.012 0.0586 0.1567
Trypanosoma brucei centrin, putative 0.0044 0.0098 0.0153
Leishmania major calmodulin, putative 0.0044 0.0098 0.0153
Plasmodium vivax vivapain-2 0.0449 0.2685 1
Giardia lamblia Cathepsin L precursor 0.012 0.0586 0.1421
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0045
Giardia lamblia Cathepsin L-like protease 0.012 0.0586 0.1421
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0315 0.1834 0.5182
Brugia malayi Cathepsin L-like precursor 0.0449 0.2685 0.2652
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0576 0.3498 1
Trypanosoma brucei centrin, putative 0.0044 0.0098 0.0153
Brugia malayi calpain 5 0.0175 0.0935 0.0894
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0044 0.0098 0.0053
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0045 0.5
Giardia lamblia Cysteine protease 0.012 0.0586 0.1421
Loa Loa (eye worm) hypothetical protein 0.0587 0.3567 0.3567
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0242 0.1363 0.1324
Echinococcus granulosus calpain 0.0242 0.1363 0.1324
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0106 0.0061
Trichomonas vaginalis calmodulin, putative 0.0044 0.0098 0.0153
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.012 0.0586 0.0543
Mycobacterium ulcerans hypothetical protein 0.0035 0.0045 0.5
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0576 0.3498 1
Leishmania major i/6 autoantigen-like protein 0.0044 0.0098 0.0153
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0044 0.0098 0.0153
Entamoeba histolytica protein kinase, putative 0.0175 0.0935 0.3235
Trypanosoma cruzi I/6 autoantigen, putative 0.0044 0.0098 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0449 0.2685 0.7647
Trypanosoma cruzi major cysteine proteinase, putative 0.012 0.0586 0.0543
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0697 0.4273 0.4247
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0067 0.0248 0.0588
Schistosoma mansoni cathepsin F (C01 family) 0.0449 0.2685 0.2652
Onchocerca volvulus Cathepsin L homolog 0.012 0.0586 0.2049
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0044 0.0098 0.0153
Trichomonas vaginalis calmodulin, putative 0.0044 0.0098 0.0153
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.012 0.0586 0.2049
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.1437 0.5176
Trypanosoma brucei calpain-like protein, putative 0.0242 0.1363 0.3817
Brugia malayi programmed cell death protein 6 0.0044 0.0098 0.0053
Leishmania major cathepsin L-like protease 0.0449 0.2685 0.7647
Plasmodium vivax unspecified product 0.0253 0.1437 0.5272
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0449 0.2685 0.2652
Echinococcus multilocularis cathepsin L 0.012 0.0586 0.0543
Onchocerca volvulus 0.012 0.0586 0.2049
Toxoplasma gondii centrin, putative 0.0044 0.0098 0.0153
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0045 0.5
Plasmodium vivax centrin-1, putative 0.0044 0.0098 0.02
Plasmodium falciparum serine repeat antigen 7 0.012 0.0586 0.1887
Trypanosoma brucei calpain, putative 0.0067 0.0248 0.0588
Echinococcus multilocularis calbindin 32 0.0044 0.0104 0.0059
Loa Loa (eye worm) hypothetical protein 0.012 0.0586 0.0586
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0204
Trypanosoma brucei Calpain-like protein CALP1.3 0.0067 0.0248 0.0588
Trypanosoma cruzi cysteine protease, putative 0.0253 0.1437 0.1398
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0067 0.0248 0.0588
Echinococcus multilocularis Tolloid protein 1 0.0045 0.0108 0.0063
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0044 0.0098 0.0053
Plasmodium falciparum serine repeat antigen 1 0.012 0.0586 0.1887
Leishmania major protein kinase, putative 0.0044 0.0098 0.0153
Entamoeba histolytica hypothetical protein 0.012 0.0586 0.1887
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0204
Loa Loa (eye worm) hypothetical protein 0.012 0.0586 0.0586
Entamoeba histolytica cysteine protease, putative 0.0253 0.1437 0.5176
Trypanosoma cruzi cysteine peptidase, putative 0.0449 0.2685 0.2652
Leishmania major centrin, putative 0.0044 0.0098 0.0153
Trypanosoma brucei calpain-like protein, putative 0.0242 0.1363 0.3817
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.012 0.0586 0.1887
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.012 0.0586 0.0543
Brugia malayi cathepsin L-like cysteine proteinase 0.012 0.0586 0.0543
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.1437 0.4032
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0204
Loa Loa (eye worm) hypothetical protein 0.0133 0.0671 0.0671
Trypanosoma brucei caltractin, putative 0.0047 0.012 0.0217
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0133 0.0671 0.0629
Brugia malayi Cathepsin L-like precursor 0.0449 0.2685 0.2652
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0588
Trichomonas vaginalis calpain, putative 0.0067 0.0248 0.0588
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0067 0.0248 0.0588
Entamoeba histolytica cysteine protease, putative 0.0253 0.1437 0.5176
Giardia lamblia Cysteine protease 0.012 0.0586 0.1421
Leishmania major phospholipase c-like protein 0.0044 0.0098 0.0153
Brugia malayi Calmodulin-like protein 0.0044 0.0098 0.0053
Trypanosoma cruzi conserved protein 0.0067 0.0248 0.0204
Echinococcus multilocularis neurocalcin 0.0044 0.0098 0.0053
Leishmania major calpain family cysteine protease-like protein 0.0067 0.0248 0.0588
Plasmodium vivax serine-repeat antigen (SERA), putative 0.012 0.0586 0.2049
Trichomonas vaginalis calmodulin, putative 0.0044 0.0098 0.0153
Trypanosoma cruzi cruzipain precursor, putative 0.0449 0.2685 0.2652
Leishmania major hypothetical protein, unknown function 0.0067 0.0248 0.0588
Leishmania major calmodulin-like protein 0.0044 0.0098 0.0153
Echinococcus granulosus EF hand domain containing family member A2 0.0044 0.0104 0.0059
Loa Loa (eye worm) papain family cysteine protease containing protein 0.012 0.0586 0.0586
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0106 0.0061
Loa Loa (eye worm) hypothetical protein 0.0133 0.0671 0.0671
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0098 0.0153
Entamoeba histolytica cysteine protease, putative 0.0253 0.1437 0.5176
Echinococcus multilocularis neuronal calcium sensor 0.0044 0.0098 0.0053
Brugia malayi cathepsin L-like precursor 0.0315 0.1834 0.1797
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0067 0.0248 0.0204
Giardia lamblia Hypothetical protein 0.012 0.0586 0.1421
Loa Loa (eye worm) fibroinase 0.0449 0.2685 0.2685
Leishmania major programmed cell death 6 protein-like protein 0.0044 0.0098 0.0153
Trypanosoma cruzi cysteine peptidase, putative 0.0253 0.1437 0.1398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.2685 0.7647
Loa Loa (eye worm) calpain 5 0.0175 0.0935 0.0935
Trichomonas vaginalis calcium binding protein, putative 0.0044 0.0098 0.0153
Leishmania major cathepsin L-like protease 0.0449 0.2685 0.7647
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0044 0.0098 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.012 0.0586 0.1567
Trichomonas vaginalis calcium binding protein, putative 0.0047 0.012 0.0217
Leishmania major hypothetical protein, conserved 0.0044 0.0098 0.0153
Trichomonas vaginalis calmodulin-2, putative 0.0044 0.0098 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0586 0.1567
Leishmania major cathepsin L-like protease 0.0449 0.2685 0.7647
Schistosoma mansoni rab 0.0044 0.0098 0.0053
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0242 0.1363 0.3817
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0045
Leishmania major hypothetical protein, conserved 0.0067 0.0248 0.0588
Echinococcus multilocularis cathepsin b 0.1594 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.012 0.0586 0.0586
Echinococcus multilocularis cysteine protease 0.0449 0.2685 0.2652
Trypanosoma brucei hypothetical protein 0.0067 0.0248 0.0588
Echinococcus multilocularis programmed cell death protein 0.0047 0.012 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0449 0.2685 0.7647
Trypanosoma cruzi kinesin, putative 0.0175 0.0935 0.0894
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.012 0.0586 0.1567
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0106 0.0061
Leishmania major calmodulin-like protein 0.0044 0.0098 0.0153
Loa Loa (eye worm) EF hand family protein 0.0044 0.0098 0.0098
Entamoeba histolytica cysteine proteinase 1, putative 0.0253 0.1437 0.5176
Brugia malayi Cathepsin L-like precursor 0.0449 0.2685 0.2652
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.2685 0.7647
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0654 0.3995 0.3968
Trichomonas vaginalis calmodulin, putative 0.0044 0.0104 0.017
Onchocerca volvulus Cathepsin L homolog 0.0449 0.2685 1
Schistosoma mansoni cathepsin C 0.012 0.0586 0.0543
Onchocerca volvulus 0.0449 0.2685 1
Echinococcus granulosus calmodulin 0.0044 0.0098 0.0053
Trichomonas vaginalis calmodulin, putative 0.0044 0.0098 0.0153
Trypanosoma cruzi Aph-1 protein, putative 0.0097 0.044 0.0397
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0045
Toxoplasma gondii preprocathepsin c precursor, putative 0.012 0.0586 0.1567
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0242 0.1363 0.1324
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0697 0.4273 0.4247
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0249 0.1412 0.1412
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.2685 0.7647
Echinococcus granulosus EF hand domain containing family member A2 0.0044 0.0098 0.0053
Onchocerca volvulus Cathepsin F homolog 0.0449 0.2685 1
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.1437 0.5176
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0044 0.0098 0.0053
Entamoeba histolytica cysteine protease, putative 0.0253 0.1437 0.5176
Giardia lamblia Cathepsin B precursor 0.012 0.0586 0.1421
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0067 0.0248 0.0204
Trichomonas vaginalis myosin light chain 1, putative 0.0044 0.0098 0.0153
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.012 0.0586 0.0543
Giardia lamblia Cathepsin L precursor 0.012 0.0586 0.1421
Plasmodium falciparum cysteine proteinase falcipain 3 0.0449 0.2685 1
Giardia lamblia Cathepsin L precursor 0.012 0.0586 0.1421
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.2685 0.7647
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.012 0.0586 0.2049
Schistosoma mansoni calmodulin related calcium binding protein 0.0044 0.0098 0.0053
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0044 0.0098 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.2685 0.7647
Schistosoma mansoni gamma-secretase subunit aph-1 0.0249 0.1412 0.1373
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.2685 0.7647
Trypanosoma brucei centrin-3 0.0047 0.012 0.0217
Giardia lamblia Cysteine protease 0.012 0.0586 0.1421
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.2685 0.7647
Plasmodium vivax vivapain-3 0.0253 0.1437 0.5272
Plasmodium falciparum serine repeat antigen 2 0.012 0.0586 0.1887
Trypanosoma brucei protein I/6 0.0044 0.0098 0.0153
Schistosoma mansoni cathepsin B (C01 family) 0.012 0.0586 0.0543
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.1437 0.5176
Echinococcus multilocularis calumenin 0.0044 0.0104 0.0059
Echinococcus granulosus gamma secretase subunit aph 1 0.0249 0.1412 0.1373
Giardia lamblia Cathepsin L-like protease 0.012 0.0586 0.1421
Schistosoma mansoni calpain C (C02 family) 0.0242 0.1363 0.1324
Echinococcus multilocularis cysteine protease 0.0449 0.2685 0.2652
Leishmania major calmodulin, putative 0.0044 0.0098 0.0153
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0315 0.1834 0.1797
Brugia malayi calpain family protein 1 0.0654 0.3995 0.3968
Loa Loa (eye worm) calpain family protein 1 0.0654 0.3995 0.3995
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.012 0.0586 0.1887
Trypanosoma cruzi Aph-1 protein, putative 0.0097 0.044 0.0397
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0045 0.5
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0204
Trypanosoma brucei antigen, putative 0.0242 0.1363 0.3817
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0106 0.0061
Trypanosoma cruzi cysteine peptidase, putative 0.0449 0.2685 0.2652
Schistosoma mansoni ef hand domain family member A2 0.0044 0.0098 0.0053
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0044 0.0098 0.0053
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0067 0.0248 0.0588
Brugia malayi Papain family cysteine protease containing protein 0.0253 0.1437 0.1398
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0242 0.1363 0.1324
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.2685 0.7647
Schistosoma mansoni neuronal calcium sensor 0.0044 0.0098 0.0053
Trypanosoma brucei mitochondrial calcium uptake 1 0.0044 0.0098 0.0153
Entamoeba histolytica cysteine protease, putative 0.0449 0.2685 1
Entamoeba histolytica hypothetical protein, conserved 0.0044 0.0104 0.0024
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0697 0.4273 0.4247
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0449 0.2685 0.2685
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0067 0.0248 0.0204
Echinococcus multilocularis EF hand domain containing family member A2 0.0044 0.0098 0.0053
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0253 0.1437 0.1398
Loa Loa (eye worm) hypothetical protein 0.012 0.0586 0.0586
Echinococcus multilocularis calcium uptake protein 1 0.0044 0.0104 0.0059
Giardia lamblia Cathepsin B precursor 0.0576 0.3498 1
Trichomonas vaginalis calmodulin, putative 0.0044 0.0098 0.0153
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0045 0.0108 0.0063
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0576 0.3498 0.3468
Loa Loa (eye worm) hypothetical protein 0.0412 0.2452 0.2452
Toxoplasma gondii cathepsin CPL 0.0449 0.2685 0.7647
Entamoeba histolytica cysteine protease, putative 0.0253 0.1437 0.5176
Giardia lamblia Hypothetical protein 0.012 0.0586 0.1421
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.012 0.0586 0.0543
Trypanosoma brucei I/6 autoantigen 0.0044 0.0098 0.0153
Loa Loa (eye worm) hypothetical protein 0.0067 0.0248 0.0248
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.2685 0.7647
Schistosoma mansoni calpain-2 (C02 family) 0.0067 0.0248 0.0204
Entamoeba histolytica cysteine protease, putative 0.0253 0.1437 0.5176
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0067 0.0248 0.0588
Echinococcus multilocularis cathepsin L cysteine protease 0.0449 0.2685 0.2652
Toxoplasma gondii cathepsin B 0.0576 0.3498 1
Giardia lamblia Cathepsin B precursor 0.012 0.0586 0.1421
Echinococcus granulosus cathepsin l1 0.0449 0.2685 0.2652
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.2685 0.7647
Plasmodium falciparum serine repeat antigen 3 0.012 0.0586 0.1887
Mycobacterium leprae Probable lipase LipE 0.0035 0.0045 0.5
Entamoeba histolytica cysteine protease, putative 0.012 0.0586 0.1887
Onchocerca volvulus 0.0044 0.0104 0.0223
Schistosoma mansoni calmodulin 0.0044 0.0098 0.0053
Leishmania major cathepsin L-like protease 0.0449 0.2685 0.7647
Leishmania major cathepsin L-like protease 0.0449 0.2685 0.7647
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.012 0.0586 0.1421
Onchocerca volvulus 0.0449 0.2685 1
Entamoeba histolytica cysteine protease, putative 0.0253 0.1437 0.5176
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.2685 0.7647
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.2685 0.7647
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.012 0.0586 0.2049
Entamoeba histolytica cysteine proteinase, putative 0.0315 0.1834 0.6711
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0067 0.0248 0.0588
Trypanosoma brucei calpain-like protein, putative 0.0242 0.1363 0.3817
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0588
Trypanosoma brucei calmodulin, putative 0.0044 0.0104 0.017
Brugia malayi Cathepsin L-like precursor 0.0449 0.2685 0.2652
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0044 0.0098 0.0053
Brugia malayi EF hand family protein 0.0044 0.0104 0.0059
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.012 0.0586 0.2049
Toxoplasma gondii EFHC1, putative 0.0044 0.0098 0.0153
Brugia malayi Cathepsin L-like precursor 0.0449 0.2685 0.2652
Brugia malayi cathepsin F-like cysteine proteinase 0.0133 0.0671 0.0629
Brugia malayi cathepsin Z-like cysteine proteinase 0.012 0.0586 0.0543
Trypanosoma cruzi I/6 autoantigen, putative 0.0044 0.0098 0.0053
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0067 0.0248 0.0588
Trichomonas vaginalis conserved hypothetical protein 0.012 0.0586 0.1567
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.2685 0.7647
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.2685 0.7647
Trypanosoma cruzi cysteine proteinase, putative 0.0253 0.1437 0.1398
Leishmania major cathepsin L-like protease 0.0449 0.2685 0.7647
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0104 0.0223
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0253 0.1437 0.1398
Giardia lamblia Cysteine protease 0.012 0.0586 0.1421
Schistosoma mansoni calpain (C02 family) 0.0242 0.1363 0.1324
Plasmodium falciparum cysteine proteinase falcipain 1 0.0253 0.1437 0.5176
Trypanosoma brucei kinesin, putative 0.0175 0.0935 0.2577
Mycobacterium ulcerans beta-lactamase 0.0035 0.0045 0.5
Leishmania major centrin, putative,caltractin, putative 0.0044 0.0098 0.0153
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0588
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0067 0.0248 0.0588
Onchocerca volvulus 0.0449 0.2685 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0588
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0067 0.0248 0.0588
Trypanosoma cruzi calmodulin, putative 0.0044 0.0098 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0588
Trypanosoma brucei calmodulin, putative 0.0044 0.0098 0.0153
Echinococcus granulosus EF HAND 1 calcium binding site 0.0044 0.0098 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.2685 0.7647
Entamoeba histolytica grainin, putative 0.0044 0.0104 0.0024
Entamoeba histolytica cysteine protease, putative 0.012 0.0586 0.1887
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0449 0.2685 0.2652
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0586 0.1567
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.012 0.0586 0.0543
Echinococcus granulosus cathepsin l1 0.0315 0.1834 0.1797
Brugia malayi calpain D 0.0067 0.0248 0.0204
Schistosoma mansoni cathepsin S (C01 family) 0.012 0.0586 0.0543
Trypanosoma cruzi calmodulin, putative 0.0044 0.0098 0.0053
Leishmania major cathepsin L-like protease 0.0449 0.2685 0.7647
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0242 0.1363 0.3817
Trypanosoma cruzi major cysteine proteinase, putative 0.012 0.0586 0.0543
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0106 0.0061
Schistosoma mansoni reticulocalbin 0.0044 0.0104 0.0059
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0253 0.1437 0.1398
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0067 0.0248 0.0204
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0045 0.0108 0.0108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0106 0.0061
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1594 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0133 0.0671 0.0629
Loa Loa (eye worm) hypothetical protein 0.0133 0.0671 0.0671
Trypanosoma brucei Calpain-like protein 2 0.0067 0.0248 0.0588
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0106 0.0106
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0242 0.1363 0.1324
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1594 1 1
Plasmodium falciparum serine repeat antigen 9 0.012 0.0586 0.1887
Entamoeba histolytica papain family cysteine protease domain containing protein 0.012 0.0586 0.1887
Brugia malayi cathepsin L precursor 0.012 0.0586 0.0543
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0576 0.3498 0.3468
Onchocerca volvulus 0.0044 0.0098 0.02
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.012 0.0586 0.1567
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0044 0.0104 0.0059
Echinococcus multilocularis cathepsin b 0.1594 1 1
Echinococcus multilocularis EF hand domain containing family member A2 0.0044 0.0104 0.0059
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.012 0.0586 0.0543
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0242 0.1363 0.1324
Onchocerca volvulus 0.0044 0.0098 0.02
Echinococcus multilocularis calpain A 0.0698 0.4279 0.4253
Plasmodium falciparum serine repeat antigen 5 0.012 0.0586 0.1887
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.2685 0.7647
Loa Loa (eye worm) cysteine protease 0.0449 0.2685 0.2685
Toxoplasma gondii cathepsin CPC2 0.012 0.0586 0.1567
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0044 0.0098 0.0153
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0588
Trypanosoma brucei cysteine peptidase, putative 0.0067 0.0248 0.0588
Echinococcus multilocularis calmodulin 0.0044 0.0098 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0586 0.1567
Brugia malayi Papain family cysteine protease containing protein 0.0253 0.1437 0.1398
Toxoplasma gondii hypothetical protein 0.0067 0.0248 0.0588
Loa Loa (eye worm) calmodulin-like protein 0.0044 0.0098 0.0098
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0204
Loa Loa (eye worm) hypothetical protein 0.0654 0.3995 0.3995
Brugia malayi Cathepsin L-like precursor 0.0133 0.0671 0.0629
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0106 0.0061
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0449 0.2685 1
Toxoplasma gondii calmodulin CAM1 0.0044 0.0104 0.017
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0588
Schistosoma mansoni Mername-AA248 (C02 family) 0.0242 0.1363 0.1324
Schistosoma mansoni cathepsin s 0.0133 0.0671 0.0629
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0044 0.0098 0.02
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.012 0.0586 0.2049
Trichomonas vaginalis calpain, putative 0.0067 0.0248 0.0588
Schistosoma mansoni centrin-related 0.0044 0.0098 0.0053
Plasmodium falciparum serine repeat antigen 6 0.012 0.0586 0.1887
Trichomonas vaginalis calcineurin B subunit, putative 0.0044 0.0104 0.017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.2685 0.7647
Echinococcus multilocularis gamma secretase subunit aph 1 0.0249 0.1412 0.1373
Trichomonas vaginalis centrin, putative 0.0044 0.0098 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0586 0.1567
Trypanosoma cruzi cysteine proteinase, putative 0.0253 0.1437 0.1398
Echinococcus multilocularis calpain 0.0242 0.1363 0.1324
Giardia lamblia Cathepsin B precursor 0.012 0.0586 0.1421
Schistosoma mansoni cathepsin F (C01 family) 0.0315 0.1834 0.1797
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.1437 0.4032
Echinococcus granulosus calbindin 32 0.0044 0.0104 0.0059
Trypanosoma cruzi cysteine peptidase, putative 0.0449 0.2685 0.2652
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1594 1 1
Trypanosoma cruzi kinesin, putative 0.0175 0.0935 0.0894
Schistosoma mansoni hypothetical protein 0.0067 0.0248 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.012 0.0586 0.1567
Trichomonas vaginalis calmodulin, putative 0.0047 0.012 0.0217
Trichomonas vaginalis calmodulin, putative 0.0044 0.0098 0.0153
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0588
Brugia malayi Papain family cysteine protease containing protein 0.012 0.0586 0.0543
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.012 0.0586 0.1567
Mycobacterium ulcerans lipase LipD 0.0035 0.0045 0.5
Loa Loa (eye worm) ctsf protein 0.0449 0.2685 0.2685
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0242 0.1363 0.3817
Echinococcus multilocularis cathepsin L 0.0253 0.1437 0.1398
Echinococcus granulosus calpain A 0.0242 0.1363 0.1324
Entamoeba histolytica cysteine protease, putative 0.012 0.0586 0.1887
Toxoplasma gondii troponin c, isotype gamma, putative 0.0044 0.0098 0.0153
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0067 0.0248 0.0204
Echinococcus granulosus cathepsin L 0.012 0.0586 0.0543
Plasmodium vivax vivapain-1 0.0253 0.1437 0.5272
Loa Loa (eye worm) hypothetical protein 0.0044 0.0098 0.0098
Echinococcus multilocularis calpain 7 (C02 family) 0.0242 0.1363 0.1324
Echinococcus multilocularis centrin 2 0.0044 0.0098 0.0053
Leishmania major cysteine peptidase A (CPA) 0.0449 0.2685 0.7647
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1594 1 1
Trichomonas vaginalis calmodulin, putative 0.0044 0.0098 0.0153
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0067 0.0248 0.0204
Echinococcus granulosus calpain 7 C02 family 0.0242 0.1363 0.1324
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0588
Echinococcus granulosus Tolloid protein 1 0.0045 0.0108 0.0063
Echinococcus granulosus calcium uptake protein 1 0.0044 0.0104 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.2685 0.7647
Loa Loa (eye worm) cathepsin B 0.0576 0.3498 0.3498
Loa Loa (eye worm) programmed cell death protein 6 0.0044 0.0104 0.0104
Echinococcus multilocularis cathepsin L cysteine protease 0.0449 0.2685 0.2652
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0044 0.0098 0.0153
Trypanosoma brucei Calpain-like protein 1.2 0.0067 0.0248 0.0588
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.012 0.0586 0.0543
Echinococcus multilocularis calpain family protein 1, d 0.0479 0.288 0.2848
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0044 0.0098 0.0053
Echinococcus multilocularis programmed cell death protein 0.0047 0.012 0.0075
Schistosoma mansoni neuronal calcium sensor 0.0044 0.0098 0.0053
Echinococcus granulosus cathepsin L cysteine proteinase 0.0449 0.2685 0.2652
Leishmania major cathepsin L-like protease 0.0449 0.2685 0.7647
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0588
Entamoeba histolytica papain family cysteine protease domain containing protein 0.012 0.0586 0.1887
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.012 0.0586 0.1567
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0588
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.012 0.0586 0.1567
Toxoplasma gondii EF hand domain-containing protein 0.0044 0.0098 0.0153
Onchocerca volvulus 0.0449 0.2685 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.012 0.0586 0.1421
Trichomonas vaginalis hypothetical protein 0.0067 0.0248 0.0588
Trichomonas vaginalis calpain, putative 0.0067 0.0248 0.0588
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.2685 0.7647
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.1437 0.4032
Brugia malayi Cathepsin L-like cysteine proteinase 0.0315 0.1834 0.1797
Schistosoma mansoni hypothetical protein 0.0044 0.0098 0.0053
Onchocerca volvulus 0.0449 0.2685 1
Echinococcus granulosus calpain A 0.0698 0.4279 0.4253
Echinococcus granulosus calpain 5 0.0242 0.1363 0.1324
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0106 0.0061
Trichomonas vaginalis calcium binding proteins, putative 0.0044 0.0098 0.0153
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0248 0.0588
Leishmania major calpain protease-like protein 0.0067 0.0248 0.0588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.2685 0.7647
Echinococcus granulosus cathepsin L 0.0253 0.1437 0.1398
Schistosoma mansoni calmodulin 0.0044 0.0098 0.0053
Loa Loa (eye worm) hypothetical protein 0.0479 0.288 0.288
Plasmodium falciparum calpain 0.0067 0.0248 0.0581
Entamoeba histolytica cysteine protease, putative 0.0253 0.1437 0.5176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.2685 0.7647
Loa Loa (eye worm) hypothetical protein 0.0043 0.0096 0.0096
Brugia malayi Cathepsin L-like precursor 0.0315 0.1834 0.1797
Trypanosoma brucei hypothetical protein, conserved 0.0044 0.0098 0.0153
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0045 0.0045
Echinococcus multilocularis calpain 5 0.0242 0.1363 0.1324
Loa Loa (eye worm) calpain family protein 1 0.0479 0.288 0.288
Loa Loa (eye worm) hypothetical protein 0.0315 0.1834 0.1834
Trypanosoma brucei Calpain-like protein 1.1 0.0067 0.0248 0.0588
Plasmodium falciparum serine repeat antigen 8 0.012 0.0586 0.1887
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.012 0.0586 0.1887
Echinococcus granulosus cathepsin b 0.1594 1 1
Onchocerca volvulus 0.0315 0.1834 0.6777
Plasmodium vivax calpain, putative 0.0242 0.1363 0.4992
Trypanosoma brucei calpain-like protein, putative 0.0242 0.1363 0.3817
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.2685 0.7647
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.012 0.0586 0.1567

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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