TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 464.342 | Formula: C22H23Cl2N3O4
H donors: 2 H acceptors: 3 LogP: 4.5 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1=C(C)NC(=C(C1c1c[nH]nc1c1ccc(cc1Cl)Cl)C(=O)OCC)C
InChi: 1S/C22H23Cl2N3O4/c1-5-30-21(28)17-11(3)26-12(4)18(22(29)31-6-2)19(17)15-10-25-27-20(15)14-8-7-13(23)9-16(14)24/h7-10,19,26H,5-6H2,1-4H3,(H,25,27)
InChiKey: GKCPQNRXJJKOSL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0177	0.0177
Trypanosoma brucei	cytoskeleton-associated protein CAP5.5, putative	0.0038	0.0122	0.0339
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0038	0.0122	0.0339
Trypanosoma cruzi	major cysteine proteinase, putative	0.0107	0.0717	0.0717
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0126	0.0883	0.0883
Entamoeba histolytica	cysteine protease, putative	0.0239	0.1856	0.5264
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0433	0.3526	0.9825
Echinococcus granulosus	sarcoplasmic calcium binding protein	0.0025	0.0014	0.0014
Echinococcus granulosus	gamma secretase subunit aph 1	0.0247	0.1924	0.1924
Trypanosoma cruzi	cysteine peptidase, putative	0.0433	0.3526	0.3526
Trypanosoma brucei	hypothetical protein	0.0038	0.0122	0.0339
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0122
Plasmodium falciparum	centrin-1	0.0025	0.0014	0.0039
Trypanosoma brucei	I/6 autoantigen	0.0025	0.0014	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0301	0.2387	0.2387
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0096	0.5
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0038	0.0122	0.0339
Brugia malayi	Cathepsin L-like precursor	0.0301	0.2387	0.2387
Leishmania major	hypothetical protein, conserved	0.0038	0.0122	0.0339
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0239	0.1856	0.1856
Schistosoma mansoni	cathepsin C	0.0107	0.0717	0.0717
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0239	0.1856	0.5172
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0132	0.0933	0.0933
Trypanosoma brucei	mitochondrial calcium uptake 1	0.0025	0.0014	0.0038
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0433	0.3526	0.9825
Schistosoma mansoni	cathepsin F (C01 family)	0.0301	0.2387	0.2387
Trypanosoma brucei	antigen, putative	0.0126	0.0883	0.246
Onchocerca volvulus		0.0025	0.0014	0.0039
Giardia lamblia	Cathepsin B precursor	0.0107	0.0717	0.1999
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0122
Brugia malayi	beta-lactamase	0.0035	0.0096	0.0096
Brugia malayi	Papain family cysteine protease containing protein	0.0107	0.0717	0.0717
Brugia malayi	calpain 5	0.0038	0.0122	0.0122
Echinococcus multilocularis	calmodulin	0.0025	0.0014	0.0014
Echinococcus multilocularis	neurocalcin	0.0025	0.0014	0.0014
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0433	0.3526	0.9825
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0107	0.0717	0.1999
Plasmodium vivax	vivapain-1	0.0239	0.1856	0.5264
Trypanosoma brucei	protein I/6	0.0025	0.0014	0.0038
Trichomonas vaginalis	hypothetical protein	0.0038	0.0122	0.0339
Plasmodium falciparum	serine repeat antigen 5	0.0107	0.0717	0.2034
Trypanosoma cruzi	kinesin, putative	0.0088	0.0555	0.0555
Giardia lamblia	Cathepsin L precursor	0.0107	0.0717	0.1999
Echinococcus multilocularis	calpain A	0.0361	0.2904	0.2904
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0096	0.0096
Entamoeba histolytica	cysteine proteinase, putative	0.0433	0.3526	1
Leishmania major	cathepsin L-like protease	0.0433	0.3526	0.9825
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0339
Onchocerca volvulus	Cathepsin L homolog	0.0433	0.3526	1
Entamoeba histolytica	calmodulin, putative	0.0025	0.0014	0.0039
Leishmania major	calpain family cysteine protease-like protein	0.0038	0.0122	0.0339
Giardia lamblia	Cathepsin L-like protease	0.0107	0.0717	0.1999
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0126	0.0883	0.246
Leishmania major	centrin, putative,caltractin, putative	0.0025	0.0014	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0096	0.0096
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0038	0.0122	0.0122
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0096	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0933	0.0933
Brugia malayi	Papain family cysteine protease containing protein	0.0107	0.0717	0.0717
Entamoeba histolytica	cysteine protease, putative	0.0239	0.1856	0.5264
Schistosoma mansoni	Sarcoplasmic calcium-binding protein (SCP).	0.0025	0.0014	0.0014
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1183	1	1
Trypanosoma cruzi	centrin, putative	0.0025	0.0014	0.0014
Trypanosoma brucei	kinesin, putative	0.0088	0.0555	0.1548
Loa Loa (eye worm)	cysteine protease	0.0433	0.3526	0.3526
Toxoplasma gondii	cathepsin CPC1	0.0107	0.0717	0.1999
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0433	0.3526	0.9825
Plasmodium falciparum	calpain	0.0038	0.0122	0.0345
Echinococcus multilocularis	calpain 7 (C02 family)	0.0126	0.0883	0.0883
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0933	0.0933
Schistosoma mansoni	calmodulin related calcium binding protein	0.0025	0.0014	0.0014
Brugia malayi	fibroinase precursor	0.0107	0.0717	0.0717
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0433	0.3526	0.9825
Trypanosoma cruzi	I/6 autoantigen, putative	0.0025	0.0014	0.0014
Plasmodium vivax	serine-repeat antigen (SERA)	0.0107	0.0717	0.2034
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0933	0.0933
Echinococcus granulosus	calpain A	0.0126	0.0883	0.0883
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.044	0.3588	0.3588
Loa Loa (eye worm)	hypothetical protein	0.0301	0.2387	0.2387
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.172	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0096	0.0096
Echinococcus multilocularis	EF hand domain containing family member A2	0.0025	0.0014	0.0014
Trypanosoma cruzi	cysteine peptidase, putative	0.0433	0.3526	0.3526
Echinococcus granulosus	EF hand domain containing family member A2	0.0025	0.0014	0.0014
Entamoeba histolytica	calcium binding family protein	0.0025	0.0014	0.0039
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0107	0.0717	0.1999
Trichomonas vaginalis	calmodulin, putative	0.0025	0.0014	0.0038
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0026	0.002	0.002
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0433	0.3526	0.9825
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0239	0.1856	0.1856
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0126	0.0883	0.0883
Brugia malayi	calpain D	0.0038	0.0122	0.0122
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0107	0.0717	0.0717
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0301	0.2387	0.6652
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0096	0.5
Giardia lamblia	Cathepsin B precursor	0.044	0.3588	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0132	0.0933	0.0933
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0107	0.0717	0.2034
Trypanosoma cruzi	calmodulin, putative	0.0025	0.0014	0.0014
Loa Loa (eye worm)	calpain family protein 1	0.0246	0.1918	0.1918
Onchocerca volvulus		0.0433	0.3526	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0433	0.3526	0.9825
Schistosoma mansoni	hypothetical protein	0.0038	0.0122	0.0122
Trypanosoma brucei	glucosamine 6-phosphate n-acetyltransferase	0.0038	0.0122	0.0339
Entamoeba histolytica	cysteine proteinase, putative	0.0239	0.1856	0.5264
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0433	0.3526	0.9825
Leishmania major	centrin, putative	0.0025	0.0014	0.0038
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0239	0.1856	0.1856
Trypanosoma brucei	calpain, putative	0.0038	0.0122	0.0339
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0014	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0717	0.0717
Toxoplasma gondii	ABC1 family protein	0.0035	0.0096	0.0267
Echinococcus multilocularis	Tolloid protein 1	0.0045	0.018	0.018
Brugia malayi	cathepsin F-like cysteine proteinase	0.0107	0.0717	0.0717
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0126	0.0883	0.0883
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0107	0.0717	0.2034
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0107	0.0717	0.2034
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0433	0.3526	1
Leishmania major	hypothetical protein, unknown function	0.0038	0.0122	0.0339
Toxoplasma gondii	troponin c, isotype gamma, putative	0.0025	0.0014	0.0038
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0107	0.0717	0.1999
Plasmodium vivax	unspecified product	0.0107	0.0717	0.2034
Brugia malayi	calpain 7	0.0126	0.0883	0.0883
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0107	0.0717	0.2034
Echinococcus multilocularis	EF hand domain containing family member A2	0.0026	0.002	0.002
Onchocerca volvulus		0.0433	0.3526	1
Trichomonas vaginalis	myosin light chain 1, putative	0.0025	0.0014	0.0038
Plasmodium vivax	unspecified product	0.0239	0.1856	0.5264
Giardia lamblia	Cysteine protease	0.0107	0.0717	0.1999
Echinococcus multilocularis	cathepsin L	0.0107	0.0717	0.0717
Giardia lamblia	Cathepsin B precursor	0.0107	0.0717	0.1999
Leishmania major	cathepsin L-like protease	0.0433	0.3526	0.9825
Trypanosoma cruzi	cruzipain precursor, putative	0.0433	0.3526	0.3526
Trypanosoma cruzi	caltractin, putative	0.0025	0.0014	0.0014
Schistosoma mansoni	rab	0.0025	0.0014	0.0014
Entamoeba histolytica	calmodulin, putative	0.0025	0.0014	0.0039
Entamoeba histolytica	cysteine protease, putative	0.0239	0.1856	0.5264
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0038	0.0122	0.0122
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0433	0.3526	0.9825
Echinococcus granulosus	calpain	0.0126	0.0883	0.0883
Leishmania major	cathepsin L-like protease	0.0433	0.3526	0.9825
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0107	0.0717	0.1999
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0107	0.0717	0.0717
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1183	1	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0339
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0883	0.246
Entamoeba histolytica	cysteine protease, putative	0.0433	0.3526	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0107	0.0717	0.2034
Schistosoma mansoni	reticulocalbin	0.0026	0.002	0.002
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0883	0.246
Trichomonas vaginalis	calmodulin, putative	0.0025	0.0014	0.0038
Giardia lamblia	Encystation-specific protease	0.0107	0.0717	0.1999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0433	0.3526	0.9825
Echinococcus multilocularis	EF HAND 1, calcium binding site	0.0025	0.0014	0.0014
Brugia malayi	gamma-secretase subunit aph-1	0.0247	0.1924	0.1924
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0107	0.0717	0.2034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0433	0.3526	0.9825
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0433	0.3526	0.9825
Plasmodium falciparum	serine repeat antigen 4	0.0107	0.0717	0.2034
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1183	1	1
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0096	0.0272
Brugia malayi	Cathepsin L-like precursor	0.0433	0.3526	0.3526
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0107	0.0717	0.2034
Trichomonas vaginalis	calcium binding proteins, putative	0.0025	0.0014	0.0038
Onchocerca volvulus		0.0035	0.0096	0.0272
Leishmania major	calmodulin, putative	0.0025	0.0014	0.0038
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0107	0.0717	0.1999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0433	0.3526	0.9825
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0107	0.0717	0.2034
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0339
Leishmania major	cathepsin L-like protease	0.0433	0.3526	0.9825
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0045	0.018	0.018
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0096	0.0096
Entamoeba histolytica	hypothetical protein	0.0107	0.0717	0.2034
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0433	0.3526	0.9825
Schistosoma mansoni	calmodulin	0.0025	0.0014	0.0014
Trypanosoma cruzi	programmed cell death 6 protein-like, putative	0.0025	0.0014	0.0014
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0433	0.3526	0.9825
Giardia lamblia	Cathepsin L-like protease	0.0107	0.0717	0.1999
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0107	0.0717	0.1999
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0107	0.0717	0.2034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0433	0.3526	0.9825
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0126	0.0883	0.0883
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0107	0.0717	0.1999
Trypanosoma brucei	caltractin, putative	0.0025	0.0014	0.0038
Schistosoma mansoni	calpain C (C02 family)	0.0126	0.0883	0.0883
Plasmodium vivax	centrin-1, putative	0.0025	0.0014	0.0039
Echinococcus multilocularis	programmed cell death protein	0.0025	0.0014	0.0014
Trypanosoma brucei	Present in the outer mitochondrial membrane proteome 33	0.0025	0.0014	0.0038
Giardia lamblia	Hypothetical protein	0.0107	0.0717	0.1999
Leishmania major	i/6 autoantigen-like protein	0.0025	0.0014	0.0038
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0107	0.0717	0.2034
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0038	0.0122	0.0122
Trichomonas vaginalis	calpain, putative	0.0038	0.0122	0.0339
Echinococcus granulosus	neurocalcin	0.0025	0.0014	0.0014
Trypanosoma cruzi	cysteine protease, putative	0.0239	0.1856	0.1856
Leishmania major	phospholipase c-like protein	0.0025	0.0014	0.0038
Trypanosoma brucei	calmodulin, putative	0.0026	0.002	0.0056
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0096	0.0267
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0045	0.018	0.018
Giardia lamblia	Cathepsin B precursor	0.0107	0.0717	0.1999
Trypanosoma brucei	hypothetical protein, conserved	0.0025	0.0014	0.0038
Trichomonas vaginalis	calcineurin B subunit, putative	0.0025	0.0014	0.0038
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0107	0.0717	0.1999
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0339
Onchocerca volvulus		0.0026	0.002	0.0057
Toxoplasma gondii	EFHC1, putative	0.0025	0.0014	0.0038
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.036	0.2898	0.2898
Schistosoma mansoni	calpain-7 (C02 family)	0.0126	0.0883	0.0883
Entamoeba histolytica	grainin 2	0.0025	0.0014	0.0039
Trypanosoma cruzi	I/6 autoantigen, putative	0.0025	0.0014	0.0014
Onchocerca volvulus	Cathepsin F homolog	0.0433	0.3526	1
Entamoeba histolytica	cysteine protease, putative	0.0239	0.1856	0.5264
Brugia malayi	Papain family cysteine protease containing protein	0.0107	0.0717	0.0717
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0107	0.0717	0.0717
Trichomonas vaginalis	calpain, putative	0.0038	0.0122	0.0339
Toxoplasma gondii	cathepsin B	0.044	0.3588	1
Loa Loa (eye worm)	EF hand family protein	0.0025	0.0014	0.0014
Plasmodium falciparum	serine repeat antigen 2	0.0107	0.0717	0.2034
Loa Loa (eye worm)	hypothetical protein	0.0246	0.1918	0.1918
Giardia lamblia	Cathepsin L precursor	0.0107	0.0717	0.1999
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.036	0.2898	0.2898
Brugia malayi	EF hand family protein	0.0026	0.002	0.002
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0433	0.3526	0.9825
Trypanosoma brucei	centrin, putative	0.0025	0.0014	0.0038
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0107	0.0717	0.0717
Trichomonas vaginalis	centrin, putative	0.0025	0.0014	0.0038
Schistosoma mansoni	mitochondrial solute carrier	0.0025	0.0014	0.0014
Echinococcus multilocularis	calbindin 32	0.0026	0.002	0.002
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0126	0.0883	0.0883
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0096	0.0096
Echinococcus multilocularis	hypothetical protein	0.0126	0.0883	0.0883
Trypanosoma brucei	calpain-like protein, putative	0.0126	0.0883	0.246
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0107	0.0717	0.0717
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0433	0.3526	0.9825
Trichomonas vaginalis	calcium binding protein, putative	0.0025	0.0014	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0014	0.0038
Trypanosoma brucei	centrin, putative	0.0025	0.0014	0.0038
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0096	0.0096
Entamoeba histolytica	cysteine protease, putative	0.0239	0.1856	0.5264
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0433	0.3526	0.9825
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0883	0.246
Echinococcus granulosus	calcium uptake protein 1	0.0026	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0164	0.0164
Giardia lamblia	Cysteine protease	0.0107	0.0717	0.1999
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.036	0.2898	0.2898
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0096	0.0557
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0107	0.0717	0.0717
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0096	0.0557
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0107	0.0717	0.0717
Toxoplasma gondii	calmodulin CAM1	0.0026	0.002	0.0056
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0301	0.2387	0.2387
Entamoeba histolytica	calcium-binding protein, putative	0.0025	0.0014	0.0039
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0239	0.1856	0.5172
Plasmodium falciparum	serine repeat antigen 3	0.0107	0.0717	0.2034
Trichomonas vaginalis	calcineurin B subunit, putative	0.0026	0.002	0.0056
Trypanosoma brucei	calpain, putative	0.0038	0.0122	0.0339
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0096	0.0096
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0339
Leishmania major	centrin, putative	0.0025	0.0014	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0122	0.0122
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.036	0.2898	0.2898
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0339
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0339
Brugia malayi	Papain family cysteine protease containing protein	0.0239	0.1856	0.1856
Trypanosoma brucei	Calpain-like protein CALP1.3	0.0038	0.0122	0.0339
Trichomonas vaginalis	calmodulin, putative	0.0026	0.002	0.0056
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0096	0.0096
Plasmodium falciparum	serine repeat antigen 6	0.0107	0.0717	0.2034
Trypanosoma brucei	Calpain-like protein 1.2	0.0038	0.0122	0.0339
Entamoeba histolytica	cysteine protease, putative	0.0239	0.1856	0.5264
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0122
Entamoeba histolytica	cysteine protease, putative	0.0107	0.0717	0.2034
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0433	0.3526	0.3526
Giardia lamblia	Hypothetical protein	0.0107	0.0717	0.1999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0239	0.1856	0.5172
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0433	0.3526	0.3526
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0107	0.0717	0.1999
Schistosoma mansoni	cathepsin s	0.0132	0.0933	0.0933
Leishmania major	kinesin, putative	0.0088	0.0555	0.1548
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0717	0.0717
Plasmodium falciparum	serine repeat antigen 1	0.0107	0.0717	0.2034
Trichomonas vaginalis	Crustacean calcium-binding protein, putative	0.0025	0.0014	0.0038
Giardia lamblia	Cysteine protease	0.0107	0.0717	0.1999
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0177	0.0177
Trichomonas vaginalis	conserved hypothetical protein	0.0107	0.0717	0.1999
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0025	0.0014	0.0039
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0433	0.3526	0.3526
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0096	0.0096
Entamoeba histolytica	cysteine proteinase, putative	0.0239	0.1856	0.5264
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0433	0.3526	0.9825
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0239	0.1856	0.5264
Brugia malayi	Calmodulin-like protein	0.0025	0.0014	0.0014
Echinococcus granulosus	cysteine protease	0.0239	0.1856	0.1856
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.044	0.3588	1
Leishmania major	programmed cell death 6 protein-like protein	0.0025	0.0014	0.0038
Plasmodium vivax	calpain, putative	0.0126	0.0883	0.2503
Loa Loa (eye worm)	calpain family protein 1	0.0334	0.2679	0.2679
Giardia lamblia	Cathepsin B precursor	0.0107	0.0717	0.1999
Brugia malayi	Cathepsin L-like precursor	0.0433	0.3526	0.3526
Onchocerca volvulus		0.0025	0.0014	0.0039
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0096	0.0267
Brugia malayi	calpain 5	0.0088	0.0555	0.0555
Trichomonas vaginalis	calmodulin-2, putative	0.0025	0.0014	0.0038
Trypanosoma cruzi	kinesin, putative	0.0088	0.0555	0.0555
Onchocerca volvulus		0.0035	0.0096	0.0272
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0096	0.0557
Schistosoma mansoni	centrin-related	0.0025	0.0014	0.0014
Brugia malayi	Papain family cysteine protease containing protein	0.0433	0.3526	0.3526
Trypanosoma brucei	cysteine peptidase C (CPC)	0.044	0.3588	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0433	0.3526	0.9825
Entamoeba histolytica	grainin, putative	0.0026	0.002	0.0057
Brugia malayi	Papain family cysteine protease containing protein	0.0239	0.1856	0.1856
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0883	0.0883
Echinococcus granulosus	cathepsin l1	0.0433	0.3526	0.3526
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0122
Leishmania major	calmodulin, putative	0.0025	0.0014	0.0038
Entamoeba histolytica	cysteine protease, putative	0.0107	0.0717	0.2034
Trichomonas vaginalis	calcium binding protein, putative	0.0025	0.0014	0.0038
Leishmania major	cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0339
Trichomonas vaginalis	calcium binding protein, putative	0.0025	0.0014	0.0038
Echinococcus multilocularis	calpain	0.0126	0.0883	0.0883
Brugia malayi	cathepsin L precursor	0.0107	0.0717	0.0717
Onchocerca volvulus		0.0433	0.3526	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0038	0.0122	0.0122
Echinococcus multilocularis	cathepsin b	0.1183	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0107	0.0717	0.1999
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0038	0.0122	0.0122
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0433	0.3526	0.9825
Echinococcus granulosus	calumenin	0.0026	0.002	0.002
Brugia malayi	calpain family protein 1	0.0334	0.2679	0.2679
Leishmania major	hypothetical protein, conserved	0.0026	0.002	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0014	0.0014
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0107	0.0717	0.1999
Schistosoma mansoni	calmodulin	0.0025	0.0014	0.0014
Trichomonas vaginalis	calmodulin, putative	0.0025	0.0014	0.0038
Entamoeba histolytica	protein kinase, putative	0.0088	0.0555	0.1576
Trypanosoma cruzi	Aph-1 protein, putative	0.0096	0.0624	0.0624
Plasmodium vivax	unspecified product	0.0132	0.0933	0.2647
Onchocerca volvulus		0.0433	0.3526	1
Brugia malayi	cathepsin L-like precursor	0.0301	0.2387	0.2387
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0096	0.0096
Loa Loa (eye worm)	cathepsin B	0.044	0.3588	0.3588
Giardia lamblia	Cathepsin B precursor	0.044	0.3588	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0107	0.0717	0.0717
Leishmania major	hypothetical protein, conserved	0.0035	0.0096	0.0267
Echinococcus multilocularis	calpain family protein 1, d	0.0246	0.1918	0.1918
Giardia lamblia	Cysteine protease	0.0107	0.0717	0.1999
Entamoeba histolytica	cysteine proteinase, putative	0.0239	0.1856	0.5264
Entamoeba histolytica	cysteine protease, putative	0.0239	0.1856	0.5264
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0433	0.3526	0.9825
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0107	0.0717	0.1999
Echinococcus multilocularis	calumenin	0.0026	0.002	0.002
Giardia lamblia	Cathepsin L precursor	0.0107	0.0717	0.1999
Schistosoma mansoni	calpain-2 (C02 family)	0.0038	0.0122	0.0122
Trypanosoma cruzi	cysteine proteinase, putative	0.0239	0.1856	0.1856
Leishmania major	cathepsin L-like protease	0.0433	0.3526	0.9825
Trichomonas vaginalis	calmodulin, putative	0.0025	0.0014	0.0038
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0433	0.3526	1
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0096	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0433	0.3526	0.3526
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0433	0.3526	0.3526
Echinococcus granulosus	cathepsin L	0.0107	0.0717	0.0717
Giardia lamblia	Cathepsin L precursor	0.0107	0.0717	0.1999
Plasmodium vivax	serine-repeat antigen (SERA)	0.0107	0.0717	0.2034
Trypanosoma cruzi	conserved protein	0.0038	0.0122	0.0122
Trypanosoma brucei	Component of motile flagella 41	0.0025	0.0014	0.0038
Plasmodium falciparum	serine repeat antigen 9	0.0107	0.0717	0.2034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0107	0.0717	0.1999
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0107	0.0717	0.0717
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0239	0.1856	0.1856
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0107	0.0717	0.2034
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0339
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0096	0.0557
Trypanosoma cruzi	cysteine peptidase, putative	0.0433	0.3526	0.3526
Trypanosoma cruzi	cysteine peptidase, putative	0.0433	0.3526	0.3526
Entamoeba histolytica	cysteine proteinase, putative	0.0301	0.2387	0.6771
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0096	0.0557
Trypanosoma brucei	calmodulin, putative	0.0025	0.0014	0.0038
Entamoeba histolytica	cysteine protease, putative	0.0107	0.0717	0.2034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0433	0.3526	0.9825
Echinococcus multilocularis	calcium uptake protein 1	0.0026	0.002	0.002
Entamoeba histolytica	cysteine protease, putative	0.0239	0.1856	0.5264
Brugia malayi	beta-lactamase family protein	0.0035	0.0096	0.0096
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0301	0.2387	0.2387
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0038	0.0122	0.0339
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0433	0.3526	0.9825
Leishmania major	calmodulin-like protein	0.0025	0.0014	0.0038
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.044	0.3588	1
Echinococcus granulosus	calmodulin	0.0025	0.0014	0.0014
Toxoplasma gondii	cathepsin CPL	0.0433	0.3526	0.9825
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0096	0.0096
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0096	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0239	0.1856	0.5264
Toxoplasma gondii	centrin, putative	0.0025	0.0014	0.0038
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0339
Brugia malayi	Cathepsin L-like precursor	0.0132	0.0933	0.0933
Mycobacterium ulcerans	lipase LipD	0.0035	0.0096	0.5
Brugia malayi	cathepsin F-like cysteine proteinase	0.0132	0.0933	0.0933
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0177	0.0177
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0433	0.3526	0.3526
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0096	0.5
Trypanosoma cruzi	cysteine proteinase, putative	0.0239	0.1856	0.1856
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0334	0.2679	0.2679
Trypanosoma cruzi	mitochondrial calcium uptake 1, putative	0.0025	0.0014	0.0014
Onchocerca volvulus		0.0433	0.3526	1
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0025	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0717	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0717	0.0717
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0433	0.3526	0.9825
Trypanosoma cruzi	centrin-3	0.0025	0.0014	0.0014
Brugia malayi	Cathepsin L-like precursor	0.0433	0.3526	0.3526
Toxoplasma gondii	hypothetical protein	0.0038	0.0122	0.0339
Plasmodium falciparum	serine repeat antigen 8	0.0107	0.0717	0.2034
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0038	0.0122	0.0339
Giardia lamblia	Hypothetical protein	0.0026	0.002	0.0056
Toxoplasma gondii	cathepsin CPC2	0.0107	0.0717	0.1999
Echinococcus multilocularis	neuronal calcium sensor	0.0025	0.0014	0.0014
Plasmodium vivax	vivapain-2	0.0433	0.3526	1
Toxoplasma gondii	calcium-dependent protein kinase	0.0026	0.002	0.0056
Brugia malayi	EF hand family protein	0.0025	0.0014	0.0014
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0433	0.3526	0.9825
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0025	0.0014	0.0014
Entamoeba histolytica	cysteine proteinase 1, putative	0.0239	0.1856	0.5264
Brugia malayi	Cathepsin L-like precursor	0.0433	0.3526	0.3526
Echinococcus multilocularis	calpain 5	0.0126	0.0883	0.0883
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0177	0.0177
Giardia lamblia	Cathepsin B precursor	0.0107	0.0717	0.1999
Onchocerca volvulus		0.0301	0.2387	0.6771
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0433	0.3526	0.9825
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0107	0.0717	0.0717
Trypanosoma cruzi	centrin, putative	0.0025	0.0014	0.0014
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0096	0.0557
Echinococcus granulosus	calpain A	0.0361	0.2904	0.2904
Leishmania major	cathepsin L-like protease	0.0433	0.3526	0.9825
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0107	0.0717	0.1999
Trichomonas vaginalis	calmodulin, putative	0.0025	0.0014	0.0038
Onchocerca volvulus		0.0433	0.3526	1
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0088	0.0555	0.1576
Trichomonas vaginalis	calcium binding protein, putative	0.0025	0.0014	0.0038
Treponema pallidum	ATP-dependent RNA helicase	0.0024	0	0.5
Loa Loa (eye worm)	ctsf protein	0.0433	0.3526	0.3526
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0107	0.0717	0.1999
Schistosoma mansoni	hypothetical protein	0.0025	0.0014	0.0014
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0122
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0433	0.3526	0.9825
Echinococcus multilocularis	cysteine protease	0.0433	0.3526	0.3526
Leishmania major	cathepsin L-like protease	0.0433	0.3526	0.9825
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0239	0.1856	0.5172
Trypanosoma brucei	cysteine peptidase, putative	0.0038	0.0122	0.0339
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0122
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0038	0.0122	0.0339
Echinococcus multilocularis	cathepsin b	0.1183	1	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0122
Entamoeba histolytica	cysteine proteinase 2	0.0239	0.1856	0.5264
Schistosoma mansoni	cathepsin B (C01 family)	0.0107	0.0717	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0717	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0301	0.2387	0.2387
Trypanosoma cruzi	Aph-1 protein, putative	0.0096	0.0624	0.0624
Trichomonas vaginalis	esterase, putative	0.0035	0.0096	0.0267
Brugia malayi	beta-lactamase family protein	0.0035	0.0096	0.0096
Trypanosoma brucei	Aph-1 protein, putative	0.0096	0.0624	0.174
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0177	0.0177
Brugia malayi	programmed cell death protein 6	0.0025	0.0014	0.0014
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0883	0.0883
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0107	0.0717	0.2034
Brugia malayi	calpain family protein 1	0.0334	0.2679	0.2679
Echinococcus multilocularis	cathepsin L cysteine protease	0.0433	0.3526	0.3526
Loa Loa (eye worm)	AStacin protease	0.0028	0.0035	0.0035
Onchocerca volvulus		0.0433	0.3526	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0107	0.0717	0.0717
Echinococcus multilocularis	centrin 2	0.0025	0.0014	0.0014
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0107	0.0717	0.2034
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0339
Schistosoma mansoni	hypothetical protein	0.0025	0.0014	0.0014
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0096	0.0267
Echinococcus multilocularis	cathepsin L cysteine protease	0.0433	0.3526	0.3526
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0122	0.0339
Loa Loa (eye worm)	calpain D	0.0038	0.0122	0.0122
Echinococcus multilocularis	sarcoplasmic calcium binding protein	0.0025	0.0014	0.0014
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0339
Trichomonas vaginalis	calmodulin, putative	0.0025	0.0014	0.0038
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0883	0.0883
Echinococcus granulosus	cathepsin L	0.0239	0.1856	0.1856
Trypanosoma cruzi	calmodulin, putative	0.0025	0.0014	0.0014
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0339
Loa Loa (eye worm)	calmodulin-like protein	0.0025	0.0014	0.0014
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0096	0.0557
Trypanosoma cruzi	cysteine peptidase, putative	0.0239	0.1856	0.1856
Echinococcus granulosus	EF HAND 1 calcium binding site	0.0025	0.0014	0.0014
Onchocerca volvulus		0.0208	0.1591	0.4513
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0107	0.0717	0.2034
Toxoplasma gondii	calpain family cysteine protease domain-containing protein	0.0038	0.0122	0.0339
Brugia malayi	Cathepsin L-like precursor	0.0433	0.3526	0.3526
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0025	0.0014	0.0039
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0038	0.0122	0.0122
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0883	0.246
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0096	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0177	0.0177
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0433	0.3526	0.9825
Schistosoma mansoni	neuronal calcium sensor	0.0025	0.0014	0.0014
Leishmania major	calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0339
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0339
Plasmodium vivax	vivapain-3	0.0239	0.1856	0.5264
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0107	0.0717	0.1999
Echinococcus granulosus	calbindin 32	0.0026	0.002	0.002
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0107	0.0717	0.0717
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0096	0.5
Giardia lamblia	Cathepsin B precursor	0.044	0.3588	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0107	0.0717	0.1999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0433	0.3526	0.9825
Echinococcus multilocularis	calmodulin	0.0025	0.0014	0.0014
Entamoeba histolytica	cysteine proteinase, putative	0.0433	0.3526	1
Entamoeba histolytica	cysteine protease, putative	0.0107	0.0717	0.2034
Leishmania major	calcineurin B subunit, putative	0.0025	0.0014	0.0038
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0096	0.0267
Echinococcus granulosus	cathepsin b	0.1183	1	1
Plasmodium vivax	hypothetical protein, conserved	0.0026	0.002	0.0057
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0132	0.0933	0.0933
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0107	0.0717	0.0717
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1183	1	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0096	0.0096
Trypanosoma brucei	calpain-like protein, putative	0.0126	0.0883	0.246
Giardia lamblia	Cathepsin L precursor	0.0107	0.0717	0.1999
Leishmania major	cysteine peptidase A (CPA)	0.0433	0.3526	0.9825
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0107	0.0717	0.0717
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0107	0.0717	0.0717
Echinococcus granulosus	programmed cell death protein	0.0025	0.0014	0.0014
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0126	0.0883	0.0883
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0177	0.0177
Trichomonas vaginalis	conserved hypothetical protein	0.0107	0.0717	0.1999
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0107	0.0717	0.1999
Toxoplasma gondii	centrin	0.0025	0.0014	0.0038
Echinococcus granulosus	cathepsin l1	0.0301	0.2387	0.2387
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0126	0.0883	0.0883
Entamoeba histolytica	cysteine protease, putative	0.0239	0.1856	0.5264
Trypanosoma cruzi	calmodulin, putative	0.0025	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0014	0.0014
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0038	0.0122	0.0122
Trypanosoma brucei	centrin-3	0.0025	0.0014	0.0038
Trichomonas vaginalis	centrin, putative	0.0025	0.0014	0.0038
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0038	0.0122	0.0339
Onchocerca volvulus		0.0107	0.0717	0.2034
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0717	0.0717
Echinococcus granulosus	EF hand domain containing family member A2	0.0026	0.002	0.002
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0433	0.3526	0.9825
Echinococcus granulosus	cathepsin b	0.1183	1	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0038	0.0122	0.0122
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0107	0.0717	0.1999
Trypanosoma brucei	calpain-like protein, putative	0.0126	0.0883	0.246
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0107	0.0717	0.1999
Loa Loa (eye worm)	hypothetical protein	0.0297	0.2352	0.2352
Entamoeba histolytica	cysteine protease, putative	0.0239	0.1856	0.5264
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0025	0.0014	0.0039
Echinococcus multilocularis	cysteine protease	0.0433	0.3526	0.3526
Schistosoma mansoni	centrin	0.0025	0.0014	0.0014
Loa Loa (eye worm)	calpain	0.0126	0.0883	0.0883
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0107	0.0717	0.1999
Entamoeba histolytica	cysteine protease, putative	0.0239	0.1856	0.5264
Loa Loa (eye worm)	hypothetical protein	0.0208	0.1591	0.1591
Schistosoma mansoni	ef hand domain family member A2	0.0025	0.0014	0.0014
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0107	0.0717	0.0717
Loa Loa (eye worm)	calpain 5	0.0088	0.0555	0.0555
Echinococcus granulosus	Tolloid protein 1	0.0045	0.018	0.018
Leishmania major	calmodulin-like protein	0.0025	0.0014	0.0038
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0038	0.0122	0.0122
Echinococcus granulosus	calpain 7 C02 family	0.0126	0.0883	0.0883
Trichomonas vaginalis	calmodulin, putative	0.0025	0.0014	0.0038
Trypanosoma cruzi	major cysteine proteinase, putative	0.0107	0.0717	0.0717
Echinococcus granulosus	cathepsin L cysteine protease	0.0239	0.1856	0.1856
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0247	0.1924	0.1924
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0177	0.0177
Loa Loa (eye worm)	fibroinase	0.0433	0.3526	0.3526
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0038	0.0122	0.0122
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0339
Toxoplasma gondii	EF hand domain-containing protein	0.0025	0.0014	0.0038
Plasmodium falciparum	serine repeat antigen 7	0.0107	0.0717	0.2034
Schistosoma mansoni	neuronal calcium sensor	0.0025	0.0014	0.0014
Entamoeba histolytica	cysteine protease, putative	0.0107	0.0717	0.2034
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0433	0.3526	0.3526
Trichomonas vaginalis	calpain, putative	0.0038	0.0122	0.0339
Brugia malayi	Cathepsin L-like precursor	0.0301	0.2387	0.2387
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0107	0.0717	0.2034
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0096	0.0557
Onchocerca volvulus	Cathepsin L homolog	0.0433	0.3526	1
Trypanosoma brucei	Calpain-like protein 1.1	0.0038	0.0122	0.0339
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0107	0.0717	0.1999
Onchocerca volvulus		0.0035	0.0096	0.0272
Entamoeba histolytica	calpain family cysteine protease, putative	0.0038	0.0122	0.0345
Schistosoma mansoni	cathepsin F (C01 family)	0.0433	0.3526	0.3526
Brugia malayi	cathepsin L-like cysteine proteinase	0.0107	0.0717	0.0717
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0433	0.3526	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0339
Echinococcus multilocularis	programmed cell death protein	0.0025	0.0014	0.0014
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0038	0.0122	0.0339
Schistosoma mansoni	calpain-7 (C02 family)	0.0126	0.0883	0.0883
Brugia malayi	Cathepsin L-like precursor	0.0433	0.3526	0.3526
Leishmania major	protein kinase, putative	0.0025	0.0014	0.0038
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0096	0.0267
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0096	0.0096
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0433	0.3526	0.9825
Loa Loa (eye worm)	programmed cell death protein 6	0.0026	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0334	0.2679	0.2679
Entamoeba histolytica	cysteine protease, putative	0.0239	0.1856	0.5264
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0096	0.0096
Echinococcus granulosus	calpain 5	0.0126	0.0883	0.0883
Brugia malayi	calcium-binding protein	0.0025	0.0014	0.0014
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0177	0.0177
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1183	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0132	0.0933	0.0933
Entamoeba histolytica	cysteine protease, putative	0.0107	0.0717	0.2034
Plasmodium vivax	vivapain-2	0.0433	0.3526	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0126	0.0883	0.0883
Loa Loa (eye worm)	hypothetical protein	0.1183	1	1
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0247	0.1924	0.1924
Trypanosoma brucei	CAMK/CAMKL family protein kinase, putative	0.0025	0.0014	0.0038
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0247	0.1924	0.1924
Echinococcus granulosus	centrin 2	0.0025	0.0014	0.0014
Trypanosoma brucei	calpain-like protein, putative	0.0126	0.0883	0.246
Schistosoma mansoni	cathepsin F (C01 family)	0.0433	0.3526	0.3526
Giardia lamblia	Cathepsin L precursor	0.0107	0.0717	0.1999
Onchocerca volvulus	Cathepsin L homolog	0.0107	0.0717	0.2034
Leishmania major	calpain protease-like protein	0.0038	0.0122	0.0339
Schistosoma mansoni	calcium binding atopy-related autoantigen	0.0026	0.002	0.002
Trichomonas vaginalis	DNA-dependent protein kinase catalytic subunit-interacting protein, putative	0.0025	0.0014	0.0038
Trichomonas vaginalis	calmodulin, putative	0.0025	0.0014	0.0038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0301	0.2387	0.6652
Leishmania major	cathepsin L-like protease	0.0433	0.3526	0.9825
Trypanosoma brucei	Calpain-like protein 2	0.0038	0.0122	0.0339
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0433	0.3526	0.9825
Echinococcus multilocularis	cathepsin L	0.0239	0.1856	0.1856
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0339
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0433	0.3526	0.9825
Schistosoma mansoni	neuronal calcium sensor	0.0025	0.0014	0.0014
Schistosoma mansoni	reticulocalbin	0.0025	0.0014	0.0014
Entamoeba histolytica	cysteine protease, putative	0.0239	0.1856	0.5264
Leishmania major	hypothetical protein, conserved	0.0025	0.0014	0.0038
Entamoeba histolytica	hypothetical protein, conserved	0.0026	0.002	0.0057
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0096	0.0557
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0038	0.0122	0.0122
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0025	0.0014	0.0014
Schistosoma mansoni	calpain (C02 family)	0.0126	0.0883	0.0883
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.044	0.3588	0.3588
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0096	0.0096
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0433	0.3526	0.9825
Echinococcus granulosus	neuronal calcium sensor	0.0025	0.0014	0.0014
Schistosoma mansoni	neuronal calcium sensor	0.0025	0.0014	0.0014

Activities

Activity type	Activity value	Assay description	Source	Reference
IZ (functional)	= 1 mm	Antifungal activity against Candida albicans MTCC 3017 at 0.5 mg/mL after 72 hrs by by agar-well diffusion method	ChEMBL.	21968373
IZ (functional)	= 1 mm	Antifungal activity against Candida albicans MTCC 3017 at 0.25 mg/mL after 72 hrs by by agar-well diffusion method	ChEMBL.	21968373
IZ (functional)	= 2 mm	Antibacterial activity against Escherichia coli ATCC 25922 at 0.25 mg/mL after 24 hrs by by agar-well diffusion method	ChEMBL.	21968373
IZ (functional)	= 4 mm	Antibacterial activity against Escherichia coli ATCC 25922 at 0.5 mg/mL after 24 hrs by by agar-well diffusion method	ChEMBL.	21968373
IZ (functional)	= 4 mm	Antifungal activity against Candida albicans MTCC 3017 at 1 mg/mL after 72 hrs by by agar-well diffusion method	ChEMBL.	21968373
IZ (functional)	= 6 mm	Antibacterial activity against Escherichia coli ATCC 25922 at 1 mg/mL after 24 hrs by by agar-well diffusion method	ChEMBL.	21968373

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1911667

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1576609