Detailed information for compound 15912

Basic information

Technical information
  • TDR Targets ID: 15912
  • Name: 3-chloropropyl(trimethyl)azanium bromide
  • MW: 216.547 | Formula: C6H15BrClN
  • H donors: 0 H acceptors: 0 LogP: 2.2 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCCC[N+](C)(C)C.[Br-]
  • InChi: 1S/C6H15ClN.BrH/c1-8(2,3)6-4-5-7;/h4-6H2,1-3H3;1H/q+1;/p-1
  • InChiKey: XMRUUKXYPYSSLI-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • 3-chloropropyl(trimethyl)ammonium bromide
  • 3-chloropropyl-trimethylazanium bromide
  • 3-chloropropyl-trimethyl-ammonium bromide
  • 3-chloropropyl-trimethylammonium bromide
  • 3-chloropropyl-trimethyl-azanium bromide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine protease, putative 0.0278 0.1432 0.483
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0132 0.0585 0.209
Trypanosoma brucei caltractin, putative 0.0081 0.0293 0.0748
Trypanosoma brucei calmodulin, putative 0.0078 0.0272 0.0688
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0539 0.2938 0.8386
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.3688 0.3688
Schistosoma mansoni centrin 0.0078 0.0272 0.0272
Trypanosoma brucei calpain-like protein, putative 0.0472 0.2552 0.7272
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0007
Echinococcus multilocularis EF hand domain containing family member A2 0.0079 0.028 0.028
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0278 0.1432 0.1432
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0078 0.0272 0.0688
Echinococcus multilocularis cysteine protease 0.0493 0.2674 0.2674
Loa Loa (eye worm) hypothetical protein 0.1759 1 1
Schistosoma mansoni hypothetical protein 0.0078 0.0272 0.0272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.0585 0.1593
Entamoeba histolytica cysteine protease, putative 0.0132 0.0585 0.1306
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0635 0.3497 1
Leishmania major hypothetical protein, conserved 0.0079 0.028 0.0712
Plasmodium falciparum serine repeat antigen 2 0.0132 0.0585 0.1306
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0493 0.2674 0.7625
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.0585 0.0585
Schistosoma mansoni calmodulin 0.0078 0.0272 0.0272
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0136 0.0609 0.0577
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0007
Echinococcus multilocularis Tolloid protein 1 0.0045 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0032 0.0007 0.0007
Leishmania major centrin, putative 0.0078 0.0272 0.0688
Echinococcus granulosus cathepsin l cysteine peptidase 0.0493 0.2674 0.2674
Trypanosoma brucei Calpain-like protein CALP1.3 0.0136 0.0609 0.1661
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0079 0.028 0.028
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0493 0.2674 0.7625
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0493 0.2674 0.7625
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0132 0.0585 0.209
Trichomonas vaginalis calpain, putative 0.0136 0.0609 0.1661
Onchocerca volvulus 0.0032 0.0007 0.0016
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0136 0.0609 0.1661
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0132 0.0585 0.1593
Loa Loa (eye worm) hypothetical protein 0.0347 0.1828 0.1828
Echinococcus granulosus calpain A 0.0472 0.2552 0.2552
Giardia lamblia Cathepsin L-like protease 0.0132 0.0585 0.0949
Onchocerca volvulus 0.0493 0.2674 0.6065
Schistosoma mansoni cathepsin B (C01 family) 0.0132 0.0585 0.0585
Echinococcus granulosus transmembrane protease serine 3 0.0032 0.0007 0.0007
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0132 0.0585 0.0585
Trichomonas vaginalis calmodulin, putative 0.0081 0.0293 0.0748
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0078 0.0272 0.0239
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0032 0.0007 0.0007
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0132 0.0585 0.209
Plasmodium falciparum cysteine proteinase falcipain 3 0.0493 0.2674 1
Echinococcus granulosus calcium uptake protein 1 0.0079 0.028 0.028
Entamoeba histolytica cysteine proteinase, putative 0.0278 0.1432 0.483
Echinococcus granulosus calpain A 0.1344 0.7599 0.7599
Loa Loa (eye worm) hypothetical protein 0.0041 0.0056 0.0056
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0034 0.5
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0032 0.0007 0.0007
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0132 0.0585 0.1593
Trypanosoma brucei cysteine peptidase C (CPC) 0.0635 0.3497 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0539 0.2938 0.8386
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0472 0.2552 0.2527
Trichomonas vaginalis calcineurin B subunit, putative 0.0078 0.0272 0.0688
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0472 0.2552 0.2527
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0091 0.0091
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0045 0.0081 0.0081
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.0585 0.0585
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0493 0.2674 0.7625
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0472 0.2552 0.2527
Trichomonas vaginalis calmodulin, putative 0.0078 0.0272 0.0688
Entamoeba histolytica cysteine proteinase, putative 0.0278 0.1432 0.483
Brugia malayi Trypsin family protein 0.0032 0.0007 0.0007
Toxoplasma gondii cathepsin B 0.0635 0.3497 1
Schistosoma mansoni calpain-7 (C02 family) 0.0472 0.2552 0.2552
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0034 0.0034
Brugia malayi Papain family cysteine protease containing protein 0.0132 0.0585 0.0585
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0175 0.0834 0.0834
Brugia malayi Cathepsin L-like precursor 0.0146 0.0668 0.0668
Trypanosoma cruzi calmodulin, putative 0.0078 0.0272 0.0239
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0091 0.0091
Brugia malayi Trypsin-like protease protein 5 0.0032 0.0007 0.0007
Entamoeba histolytica cysteine proteinase, putative 0.0278 0.1432 0.483
Trypanosoma cruzi cysteine peptidase, putative 0.0278 0.1432 0.1403
Trypanosoma brucei Calpain-like protein 1.2 0.0136 0.0609 0.1661
Echinococcus multilocularis cathepsin L cysteine protease 0.0493 0.2674 0.2674
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0091 0.0091
Loa Loa (eye worm) trypsin family protein 0.0032 0.0007 0.0007
Echinococcus granulosus cathepsin b 0.1759 1 1
Schistosoma mansoni calpain (C02 family) 0.0472 0.2552 0.2552
Trypanosoma cruzi caltractin, putative 0.0078 0.0272 0.0239
Schistosoma mansoni hypothetical protein 0.0136 0.0609 0.0609
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0078 0.0272 0.0239
Leishmania major centrin, putative 0.0078 0.0272 0.0688
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1759 1 1
Loa Loa (eye worm) calpain 5 0.0336 0.1765 0.1765
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0132 0.0585 0.0585
Brugia malayi cathepsin Z-like cysteine proteinase 0.0132 0.0585 0.0585
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0278 0.1432 0.4038
Echinococcus granulosus cathepsin b 0.1759 1 1
Entamoeba histolytica grainin 2 0.0081 0.0293 0.0087
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0132 0.0585 0.0949
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0146 0.0668 0.0668
Echinococcus granulosus microtubule associated protein 2 0.0668 0.3688 0.3688
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0132 0.0585 0.0585
Entamoeba histolytica cysteine protease, putative 0.0132 0.0585 0.1306
Giardia lamblia Cathepsin L precursor 0.0132 0.0585 0.0949
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0007 0.0007
Leishmania major calmodulin, putative 0.0078 0.0272 0.0688
Trypanosoma brucei Calpain-like protein 1.1 0.0136 0.0609 0.1661
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0472 0.2552 0.7272
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0132 0.0585 0.1306
Echinococcus multilocularis calpain A 0.1344 0.7599 0.7599
Brugia malayi EF hand family protein 0.0078 0.0272 0.0272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0539 0.2938 0.8386
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0132 0.0585 0.1306
Giardia lamblia Cathepsin B precursor 0.0635 0.3497 1
Trichomonas vaginalis calmodulin, putative 0.0078 0.0272 0.0688
Trypanosoma brucei Aph-1 protein, putative 0.0095 0.0371 0.0973
Schistosoma mansoni cathepsin F (C01 family) 0.0493 0.2674 0.2674
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0078 0.0272 0.0272
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0007 0.0007
Plasmodium falciparum serine repeat antigen 7 0.0132 0.0585 0.1306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.0585 0.1593
Trypanosoma brucei calmodulin, putative 0.0079 0.028 0.0712
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0041 0.0056 0.0056
Brugia malayi calpain family protein 1 0.1265 0.714 0.714
Echinococcus multilocularis gamma secretase subunit aph 1 0.0244 0.1231 0.1231
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0007 0.0007
Echinococcus granulosus Tolloid protein 1 0.0045 0.0081 0.0081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0132 0.0585 0.1593
Giardia lamblia Cathepsin B precursor 0.0132 0.0585 0.0949
Trichomonas vaginalis calcium binding protein, putative 0.0078 0.0272 0.0688
Loa Loa (eye worm) hypothetical protein 0.0132 0.0585 0.0585
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0278 0.1432 0.1403
Plasmodium vivax serine-repeat antigen (SERA) 0.0132 0.0585 0.209
Trypanosoma cruzi major cysteine proteinase, putative 0.0178 0.0849 0.0818
Echinococcus granulosus neuronal calcium sensor 0.0078 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.1661
Schistosoma mansoni calpain C (C02 family) 0.0472 0.2552 0.2552
Brugia malayi Cathepsin L-like precursor 0.0347 0.1828 0.1828
Trichomonas vaginalis calcium binding protein, putative 0.0078 0.0272 0.0688
Brugia malayi Cathepsin L-like precursor 0.0493 0.2674 0.2674
Trypanosoma cruzi kinesin, putative 0.0336 0.1765 0.1737
Loa Loa (eye worm) hypothetical protein 0.0347 0.1828 0.1828
Plasmodium vivax centrin-1, putative 0.0078 0.0272 0.0902
Plasmodium vivax vivapain-1 0.0278 0.1432 0.5297
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.1661
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0007 0.0007
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0132 0.0585 0.0585
Echinococcus granulosus inhibitor of apoptosis protein 0.0041 0.0056 0.0056
Loa Loa (eye worm) beta-lactamase 0.0037 0.0034 0.0034
Trypanosoma cruzi I/6 autoantigen, putative 0.0078 0.0272 0.0239
Echinococcus granulosus glycoprotein Antigen 5 0.0032 0.0007 0.0007
Plasmodium vivax serine-repeat antigen (SERA) 0.0132 0.0585 0.209
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.0577
Leishmania major hypothetical protein, unknown function 0.0136 0.0609 0.1661
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0091 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0493 0.2674 0.7625
Leishmania major calmodulin, putative 0.0078 0.0272 0.0688
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1759 1 1
Mycobacterium ulcerans lipase LipD 0.0037 0.0034 1
Plasmodium vivax unspecified product 0.0278 0.1432 0.5297
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0132 0.0585 0.209
Leishmania major hypothetical protein, conserved 0.0136 0.0609 0.1661
Entamoeba histolytica cysteine protease, putative 0.0278 0.1432 0.483
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0091 0.0091
Entamoeba histolytica calpain family cysteine protease, putative 0.0136 0.0609 0.1403
Loa Loa (eye worm) hypothetical protein 0.0078 0.0272 0.0272
Giardia lamblia Cathepsin L-like protease 0.0132 0.0585 0.0949
Trypanosoma brucei calpain, putative 0.0136 0.0609 0.1661
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0493 0.2674 0.2674
Entamoeba histolytica cysteine protease, putative 0.0278 0.1432 0.483
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0373 0.1982 0.1982
Brugia malayi Trypsin family protein 0.0032 0.0007 0.0007
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0041 0.0056 0.0056
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.0577
Onchocerca volvulus 0.0493 0.2674 0.6065
Schistosoma mansoni hypothetical protein 0.0032 0.0007 0.0007
Echinococcus granulosus cathepsin L 0.0132 0.0585 0.0585
Trypanosoma cruzi cysteine peptidase, putative 0.0493 0.2674 0.265
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0472 0.2552 0.7272
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0132 0.0585 0.1593
Entamoeba histolytica cysteine protease, putative 0.0493 0.2674 1
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.3688 0.3688
Toxoplasma gondii troponin c, isotype gamma, putative 0.0078 0.0272 0.0688
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0078 0.0272 0.0688
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0175 0.0834 0.1892
Leishmania major cathepsin L-like protease 0.0493 0.2674 0.7625
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0539 0.2938 0.8386
Entamoeba histolytica cysteine proteinase, putative 0.0493 0.2674 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0136 0.0609 0.0577
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0493 0.2674 0.2674
Mycobacterium leprae Probable lipase LipE 0.0037 0.0034 0.5
Giardia lamblia Encystation-specific protease 0.0132 0.0585 0.0949
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0059 0.0162 0.0162
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0034 0.0034
Leishmania major i/6 autoantigen-like protein 0.0078 0.0272 0.0688
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0132 0.0585 0.209
Echinococcus multilocularis cysteine protease 0.0493 0.2674 0.2674
Echinococcus multilocularis neuronal calcium sensor 0.0078 0.0272 0.0272
Trypanosoma cruzi I/6 autoantigen, putative 0.0078 0.0272 0.0239
Trichomonas vaginalis hypothetical protein 0.0136 0.0609 0.1661
Trichomonas vaginalis calmodulin, putative 0.0078 0.0272 0.0688
Onchocerca volvulus Cathepsin L homolog 0.0493 0.2674 0.6065
Echinococcus granulosus Dipeptidyl peptidase 9 0.0059 0.0162 0.0162
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0472 0.2552 0.7272
Leishmania major cathepsin L-like protease 0.0493 0.2674 0.7625
Brugia malayi calpain 7 0.0472 0.2552 0.2552
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0132 0.0585 0.1306
Entamoeba histolytica cysteine protease, putative 0.0278 0.1432 0.483
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0132 0.0585 0.0949
Brugia malayi Cathepsin L-like precursor 0.0493 0.2674 0.2674
Entamoeba histolytica cysteine proteinase, putative 0.0347 0.1828 0.6475
Leishmania major cathepsin L-like protease 0.0493 0.2674 0.7625
Brugia malayi hypothetical protein 0.0045 0.0082 0.0082
Echinococcus granulosus centrin 2 0.0078 0.0272 0.0272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0493 0.2674 0.7625
Trypanosoma cruzi conserved protein 0.0136 0.0609 0.0577
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0244 0.1231 0.1231
Toxoplasma gondii EF hand domain-containing protein 0.0078 0.0272 0.0688
Echinococcus multilocularis Mastin 0.0032 0.0007 0.0007
Trypanosoma cruzi cruzipain precursor, putative 0.0146 0.0668 0.0637
Plasmodium falciparum serine repeat antigen 3 0.0132 0.0585 0.1306
Onchocerca volvulus 0.0493 0.2674 0.6065
Entamoeba histolytica cysteine protease, putative 0.0278 0.1432 0.483
Brugia malayi cathepsin L-like precursor 0.0347 0.1828 0.1828
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Brugia malayi prolyl oligopeptidase family protein 0.0059 0.0162 0.0162
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0041 0.0056 0.0056
Entamoeba histolytica grainin, putative 0.0079 0.028 0.0035
Schistosoma mansoni cathepsin C 0.0132 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0472 0.2552 0.2527
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0136 0.0609 0.1661
Trypanosoma cruzi kinesin, putative 0.0336 0.1765 0.1737
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0132 0.0585 0.0585
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0493 0.2674 1
Giardia lamblia Cathepsin B precursor 0.0132 0.0585 0.0949
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0078 0.0272 0.0688
Brugia malayi cathepsin L-like cysteine proteinase 0.0132 0.0585 0.0585
Onchocerca volvulus 0.0078 0.0272 0.0616
Plasmodium vivax vivapain-2 0.0493 0.2674 1
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0272 0.0688
Plasmodium falciparum calpain 0.0136 0.0609 0.1403
Onchocerca volvulus 0.0493 0.2674 0.6065
Brugia malayi prolyl oligopeptidase family protein 0.0175 0.0834 0.0834
Toxoplasma gondii cathepsin CPC2 0.0132 0.0585 0.1593
Onchocerca volvulus 0.0041 0.0056 0.0127
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0078 0.0272 0.0239
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0373 0.1982 0.1982
Trypanosoma cruzi Aph-1 protein, putative 0.0095 0.0371 0.0338
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0132 0.0585 0.1593
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1759 1 1
Trypanosoma cruzi Aph-1 protein, putative 0.0095 0.0371 0.0338
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0036 0.0029 0.0029
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0175 0.0834 0.0834
Echinococcus granulosus gamma secretase subunit aph 1 0.0244 0.1231 0.1231
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0132 0.0585 0.1593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0493 0.2674 0.7625
Trypanosoma brucei Component of motile flagella 41 0.0078 0.0272 0.0688
Giardia lamblia Cathepsin L precursor 0.0132 0.0585 0.0949
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0132 0.0585 0.1593
Entamoeba histolytica cysteine protease, putative 0.0132 0.0585 0.1306
Leishmania major cysteine peptidase A (CPA) 0.0493 0.2674 0.7625
Trypanosoma cruzi cysteine protease, putative 0.0278 0.1432 0.1403
Echinococcus multilocularis programmed cell death protein 0.0081 0.0293 0.0293
Toxoplasma gondii calmodulin CAM1 0.0079 0.028 0.0712
Schistosoma mansoni cathepsin F (C01 family) 0.0493 0.2674 0.2674
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0136 0.0609 0.1661
Trypanosoma cruzi cysteine peptidase, putative 0.0539 0.2938 0.2914
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.0577
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.1661
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0132 0.0585 0.1593
Trypanosoma cruzi calmodulin, putative 0.0078 0.0272 0.0239
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.1661
Trypanosoma brucei Calpain-like protein 2 0.0136 0.0609 0.1661
Brugia malayi Cathepsin L-like cysteine proteinase 0.0347 0.1828 0.1828
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0493 0.2674 0.7625
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.0585 0.0585
Echinococcus multilocularis calbindin 32 0.0079 0.028 0.028
Toxoplasma gondii centrin 0.0078 0.0272 0.0688
Brugia malayi Cathepsin L-like precursor 0.0493 0.2674 0.2674
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0032 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0132 0.0585 0.0585
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0079 0.028 0.0247
Trypanosoma brucei antigen, putative 0.0472 0.2552 0.7272
Loa Loa (eye worm) hypothetical protein 0.0146 0.0668 0.0668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0347 0.1828 0.5179
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0136 0.0609 0.1661
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0539 0.2938 0.8386
Onchocerca volvulus 0.0032 0.0007 0.0016
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0392 0.2091 0.2065
Onchocerca volvulus 0.0132 0.0585 0.1328
Echinococcus multilocularis calmodulin 0.0078 0.0272 0.0272
Giardia lamblia Cysteine protease 0.0132 0.0585 0.0949
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.0585 0.1593
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0007
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0059 0.0162 0.0129
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0007 0.0007
Trypanosoma brucei kinesin, putative 0.0336 0.1765 0.4999
Brugia malayi Cathepsin L-like precursor 0.0493 0.2674 0.2674
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0007 0.0007
Loa Loa (eye worm) programmed cell death protein 6 0.0079 0.028 0.028
Schistosoma mansoni Mername-AA248 (C02 family) 0.0472 0.2552 0.2552
Loa Loa (eye worm) calpain family protein 1 0.1265 0.714 0.714
Brugia malayi calpain family protein 1 0.1265 0.714 0.714
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0078 0.0272 0.0239
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0132 0.0585 0.1593
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0373 0.1982 0.1982
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0278 0.1432 0.4038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.0585 0.1593
Entamoeba histolytica cysteine proteinase 1, putative 0.0278 0.1432 0.483
Trichomonas vaginalis calcium binding protein, putative 0.0081 0.0293 0.0748
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0493 0.2674 0.7625
Echinococcus granulosus calbindin 32 0.0079 0.028 0.028
Plasmodium vivax vivapain-2 0.0493 0.2674 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0635 0.3497 1
Echinococcus granulosus calmodulin 0.0078 0.0272 0.0272
Giardia lamblia Cathepsin B precursor 0.0132 0.0585 0.0949
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1343 0.7591 0.7591
Echinococcus multilocularis calpain 0.0472 0.2552 0.2552
Echinococcus multilocularis calumenin 0.0079 0.028 0.028
Loa Loa (eye worm) ctsf protein 0.0493 0.2674 0.2674
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0034 0.0034
Echinococcus granulosus calumenin 0.0079 0.028 0.028
Trichomonas vaginalis calmodulin, putative 0.0079 0.028 0.0712
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0007 0.0007
Schistosoma mansoni neuronal calcium sensor 0.0078 0.0272 0.0272
Trypanosoma cruzi centrin, putative 0.0081 0.0293 0.026
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0175 0.0834 0.0834
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0007 0.0007
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0007 0.0007
Leishmania major calcineurin B subunit, putative 0.0078 0.0272 0.0688
Onchocerca volvulus 0.0793 0.4409 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.0577
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0472 0.2552 0.7272
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.1661
Brugia malayi calcium-binding protein 0.0078 0.0272 0.0272
Giardia lamblia Cathepsin L precursor 0.0132 0.0585 0.0949
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0635 0.3497 0.3497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0493 0.2674 0.7625
Trypanosoma cruzi cysteine peptidase, putative 0.0539 0.2938 0.2914
Plasmodium vivax unspecified product 0.0146 0.0668 0.2404
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0472 0.2552 0.2527
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0539 0.2938 0.8386
Echinococcus granulosus EF hand domain containing family member A2 0.0078 0.0272 0.0272
Trypanosoma cruzi cysteine proteinase, putative 0.0278 0.1432 0.1403
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.1661
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0132 0.0585 0.0949
Leishmania major calpain family cysteine protease-like protein 0.0136 0.0609 0.1661
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0132 0.0585 0.0585
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.1661
Schistosoma mansoni calmodulin related calcium binding protein 0.0078 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0132 0.0585 0.1593
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.0585 0.0585
Trypanosoma cruzi major cysteine proteinase, putative 0.0132 0.0585 0.0554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.0585 0.1593
Echinococcus granulosus calpain 5 0.0472 0.2552 0.2552
Trichomonas vaginalis calcineurin B subunit, putative 0.0079 0.028 0.0712
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0034 1
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0136 0.0609 0.1661
Leishmania major hypothetical protein, conserved 0.0078 0.0272 0.0688
Echinococcus granulosus cathepsin l1 0.0347 0.1828 0.1828
Echinococcus multilocularis cathepsin L 0.0132 0.0585 0.0585
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.1176 1
Schistosoma mansoni cathepsin S (C01 family) 0.0132 0.0585 0.0585
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0493 0.2674 0.7625
Loa Loa (eye worm) prolyl oligopeptidase 0.0175 0.0834 0.0834
Onchocerca volvulus 0.0078 0.0272 0.0616
Brugia malayi cathepsin F-like cysteine proteinase 0.0146 0.0668 0.0668
Brugia malayi gamma-secretase subunit aph-1 0.0244 0.1231 0.1231
Trypanosoma cruzi centrin-3 0.0081 0.0293 0.026
Trichomonas vaginalis centrin, putative 0.0078 0.0272 0.0688
Trypanosoma brucei calpain-like protein, putative 0.0472 0.2552 0.7272
Trypanosoma brucei mitochondrial calcium uptake 1 0.0078 0.0272 0.0688
Schistosoma mansoni calpain-7 (C02 family) 0.0472 0.2552 0.2552
Echinococcus multilocularis calcium uptake protein 1 0.0079 0.028 0.028
Giardia lamblia Hypothetical protein 0.0132 0.0585 0.0949
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0132 0.0585 0.209
Leishmania major programmed cell death 6 protein-like protein 0.0078 0.0272 0.0688
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.0577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0493 0.2674 0.7625
Trichomonas vaginalis calmodulin-2, putative 0.0078 0.0272 0.0688
Giardia lamblia Cathepsin L precursor 0.0132 0.0585 0.0949
Toxoplasma gondii calcium-dependent protein kinase 0.0079 0.028 0.0712
Onchocerca volvulus 0.0347 0.1828 0.4145
Mycobacterium ulcerans hypothetical protein 0.0037 0.0034 1
Brugia malayi Papain family cysteine protease containing protein 0.0278 0.1432 0.1432
Onchocerca volvulus 0.0493 0.2674 0.6065
Leishmania major calmodulin-like protein 0.0078 0.0272 0.0688
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.0577
Entamoeba histolytica cysteine protease, putative 0.0132 0.0585 0.1306
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0493 0.2674 0.7625
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0278 0.1432 0.4038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0091 0.0091
Brugia malayi cathepsin F-like cysteine proteinase 0.0132 0.0585 0.0585
Echinococcus multilocularis cathepsin b 0.1759 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0007
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.0577
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0493 0.2674 0.7625
Leishmania major cathepsin L-like protease 0.0539 0.2938 0.8386
Leishmania major protein kinase, putative 0.0078 0.0272 0.0688
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0007 0.0007
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0132 0.0585 0.1306
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.1661
Echinococcus multilocularis transmembrane protease serine 3 0.0032 0.0007 0.0007
Schistosoma mansoni neuronal calcium sensor 0.0078 0.0272 0.0272
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0007 0.0007
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.1661
Trichomonas vaginalis centrin, putative 0.0078 0.0272 0.0688
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0493 0.2674 0.7625
Leishmania major centrin, putative,caltractin, putative 0.0078 0.0272 0.0688
Plasmodium vivax unspecified product 0.0132 0.0585 0.209
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0278 0.1432 0.4038
Leishmania major cathepsin L-like protease 0.0539 0.2938 0.8386
Schistosoma mansoni calpain-2 (C02 family) 0.0136 0.0609 0.0609
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0037 0.0034 0.0076
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.0585 0.0585
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0493 0.2674 0.7625
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.1661
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0493 0.2674 1
Trypanosoma brucei centrin, putative 0.0078 0.0272 0.0688
Trichomonas vaginalis myosin light chain 1, putative 0.0078 0.0272 0.0688
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0091 0.0091
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0132 0.0585 0.0949
Giardia lamblia Cathepsin L precursor 0.0132 0.0585 0.0949
Trypanosoma cruzi centrin, putative 0.0081 0.0293 0.026
Echinococcus multilocularis glycoprotein Antigen 5 0.0032 0.0007 0.0007
Schistosoma mansoni calmodulin 0.0078 0.0272 0.0272
Schistosoma mansoni reticulocalbin 0.0079 0.028 0.028
Echinococcus multilocularis calpain 5 0.0472 0.2552 0.2552
Brugia malayi Cathepsin L-like precursor 0.0493 0.2674 0.2674
Trypanosoma cruzi calmodulin, putative 0.0078 0.0272 0.0239
Echinococcus granulosus cathepsin L cysteine proteinase 0.0493 0.2674 0.2674
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1265 0.714 0.714
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0493 0.2674 0.7625
Schistosoma mansoni cathepsin F (C01 family) 0.0347 0.1828 0.1828
Brugia malayi Calmodulin-like protein 0.0078 0.0272 0.0272
Onchocerca volvulus 0.0493 0.2674 0.6065
Plasmodium vivax calpain, putative 0.0472 0.2552 0.9538
Schistosoma mansoni reticulocalbin 0.0078 0.0272 0.0272
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0472 0.2552 0.2527
Brugia malayi beta-lactamase family protein 0.0037 0.0034 0.0034
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0034 0.0034
Plasmodium vivax vivapain-3 0.0278 0.1432 0.5297
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.1343 0.7591 0.7591
Schistosoma mansoni mitochondrial solute carrier 0.0078 0.0272 0.0272
Schistosoma mansoni neuronal calcium sensor 0.0078 0.0272 0.0272
Onchocerca volvulus 0.0032 0.0007 0.0016
Brugia malayi Papain family cysteine protease containing protein 0.0278 0.1432 0.1432
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0041 0.0056 0.0056
Loa Loa (eye worm) EF hand family protein 0.0078 0.0272 0.0272
Trypanosoma brucei calpain, putative 0.0136 0.0609 0.1661
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0032 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0146 0.0668 0.0668
Toxoplasma gondii centrin, putative 0.0078 0.0272 0.0688
Brugia malayi beta-lactamase 0.0037 0.0034 0.0034
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0136 0.0609 0.1661
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0539 0.2938 0.8386
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0136 0.0609 0.1661
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0136 0.0609 0.0577
Onchocerca volvulus 0.0032 0.0007 0.0016
Entamoeba histolytica cysteine protease, putative 0.0278 0.1432 0.483
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0539 0.2938 0.8386
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0036 0.0029 0.0029
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0136 0.0609 0.1661
Echinococcus multilocularis cathepsin b 0.1759 1 1
Echinococcus multilocularis programmed cell death protein 0.0081 0.0293 0.0293
Onchocerca volvulus Cathepsin L homolog 0.0493 0.2674 0.6065
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0007 0.0007
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0136 0.0609 0.0577
Onchocerca volvulus Cathepsin L homolog 0.0132 0.0585 0.1328
Trypanosoma brucei protein I/6 0.0078 0.0272 0.0688
Trypanosoma cruzi cruzipain precursor, putative 0.0539 0.2938 0.2914
Schistosoma mansoni rab 0.0078 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0136 0.0609 0.0609
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0059 0.0162 0.0162
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0132 0.0585 0.0585
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.1661
Trichomonas vaginalis calmodulin, putative 0.0078 0.0272 0.0688
Loa Loa (eye worm) cathepsin B 0.0635 0.3497 0.3497
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.1661
Giardia lamblia Cysteine protease 0.0132 0.0585 0.0949
Echinococcus granulosus cathepsin l1 0.0493 0.2674 0.2674
Entamoeba histolytica hypothetical protein, conserved 0.0079 0.028 0.0035
Plasmodium falciparum cysteine proteinase falcipain 1 0.0278 0.1432 0.483
Echinococcus multilocularis calmodulin 0.0078 0.0272 0.0272
Echinococcus granulosus neurocalcin 0.0078 0.0272 0.0272
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0059 0.0162 0.0371
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.1661
Loa Loa (eye worm) hypothetical protein 0.1129 0.6353 0.6353
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0136 0.0609 0.0577
Echinococcus granulosus calpain 0.0472 0.2552 0.2552
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0493 0.2674 0.2674
Loa Loa (eye worm) hypothetical protein 0.0793 0.4409 0.4409
Schistosoma mansoni centrin-related 0.0078 0.0272 0.0272
Entamoeba histolytica cysteine proteinase 2 0.0278 0.1432 0.483
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0078 0.0272 0.0272
Trichomonas vaginalis calmodulin, putative 0.0078 0.0272 0.0688
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0007
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0278 0.1432 0.1432
Echinococcus granulosus programmed cell death protein 0.0081 0.0293 0.0293
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0278 0.1432 0.1432
Echinococcus multilocularis neurocalcin 0.0078 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0136 0.0609 0.1661
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0059 0.0162 0.0371
Giardia lamblia Cathepsin B precursor 0.0635 0.3497 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.1343 0.7591 0.7591
Brugia malayi cathepsin L precursor 0.0132 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0132 0.0585 0.0585
Leishmania major cathepsin L-like protease 0.0493 0.2674 0.7625
Loa Loa (eye worm) hypothetical protein 0.0078 0.0272 0.0272
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0078 0.0272 0.0239
Echinococcus granulosus calpain 7 C02 family 0.0472 0.2552 0.2552
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.1661
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0007 0.0007
Loa Loa (eye worm) fibroinase 0.0493 0.2674 0.2674
Echinococcus granulosus enteropeptidase 0.0032 0.0007 0.0007
Schistosoma mansoni inhibitor of apoptosis protein 0.0041 0.0056 0.0056
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.1661
Trichomonas vaginalis calcium binding proteins, putative 0.0078 0.0272 0.0688
Entamoeba histolytica hypothetical protein 0.0132 0.0585 0.1306
Toxoplasma gondii cathepsin CPC1 0.0132 0.0585 0.1593
Echinococcus multilocularis enteropeptidase 0.0032 0.0007 0.0007
Leishmania major phospholipase c-like protein 0.0078 0.0272 0.0688
Echinococcus multilocularis cathepsin L 0.0278 0.1432 0.1432
Echinococcus multilocularis EF hand domain containing family member A2 0.0078 0.0272 0.0272
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0493 0.2674 0.7625
Loa Loa (eye worm) cysteine protease 0.0493 0.2674 0.2674
Loa Loa (eye worm) hypothetical protein 0.0146 0.0668 0.0668
Echinococcus multilocularis expressed protein 0.0361 0.1913 0.1913
Brugia malayi hypothetical protein 0.0032 0.0007 0.0007
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0146 0.0668 0.0668
Schistosoma mansoni neuronal calcium sensor 0.0078 0.0272 0.0272
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0059 0.0162 0.0371
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Giardia lamblia Hypothetical protein 0.0132 0.0585 0.0949
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0347 0.1828 0.5179
Plasmodium falciparum serine repeat antigen 6 0.0132 0.0585 0.1306
Trypanosoma brucei centrin-3 0.0081 0.0293 0.0748
Onchocerca volvulus Deterin homolog 0.0041 0.0056 0.0127
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0078 0.0272 0.0272
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0041 0.0056 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0132 0.0585 0.1593
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0034 1
Trypanosoma cruzi cysteine peptidase, putative 0.0146 0.0668 0.0637
Toxoplasma gondii EFHC1, putative 0.0078 0.0272 0.0688
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0472 0.2552 0.2527
Schistosoma mansoni hypothetical protein 0.0078 0.0272 0.0272
Plasmodium falciparum serine repeat antigen 8 0.0132 0.0585 0.1306
Loa Loa (eye worm) calpain 0.0472 0.2552 0.2552
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.1661
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0059 0.0162 0.0371
Onchocerca volvulus 0.0493 0.2674 0.6065
Plasmodium falciparum serine repeat antigen 9 0.0132 0.0585 0.1306
Plasmodium falciparum serine repeat antigen 4 0.0132 0.0585 0.1306
Loa Loa (eye worm) hypothetical protein 0.0493 0.2674 0.2674
Echinococcus granulosus expressed protein 0.0361 0.1913 0.1913
Onchocerca volvulus Cathepsin F homolog 0.0493 0.2674 0.6065
Entamoeba histolytica cysteine protease, putative 0.0278 0.1432 0.483
Plasmodium falciparum serine repeat antigen 5 0.0132 0.0585 0.1306
Toxoplasma gondii hypothetical protein 0.0136 0.0609 0.1661
Brugia malayi Papain family cysteine protease containing protein 0.0493 0.2674 0.2674
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0472 0.2552 0.7272
Brugia malayi EF hand family protein 0.0079 0.028 0.028
Leishmania major cathepsin L-like protease 0.0493 0.2674 0.7625
Brugia malayi calpain 5 0.0336 0.1765 0.1765
Loa Loa (eye worm) hypothetical protein 0.1265 0.714 0.714
Trypanosoma cruzi cysteine peptidase, putative 0.0539 0.2938 0.2914
Loa Loa (eye worm) calmodulin-like protein 0.0078 0.0272 0.0272
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0091 0.0091
Leishmania major calpain protease-like protein 0.0136 0.0609 0.1661
Mycobacterium ulcerans beta-lactamase 0.0037 0.0034 1
Trypanosoma brucei centrin, putative 0.0078 0.0272 0.0688
Trichomonas vaginalis calmodulin, putative 0.0078 0.0272 0.0688
Entamoeba histolytica cysteine protease, putative 0.0278 0.1432 0.483
Echinococcus granulosus Mastin 0.0032 0.0007 0.0007
Schistosoma mansoni cathepsin s 0.0146 0.0668 0.0668
Trichomonas vaginalis calpain, putative 0.0136 0.0609 0.1661
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1759 1 1
Brugia malayi fibroinase precursor 0.0132 0.0585 0.0585
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0493 0.2674 0.2674
Leishmania major cathepsin L-like protease 0.0539 0.2938 0.8386
Entamoeba histolytica cysteine protease, putative 0.0278 0.1432 0.483
Brugia malayi calpain 5 0.0136 0.0609 0.0609
Echinococcus multilocularis calpain family protein 1, d 0.0929 0.5197 0.5197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0539 0.2938 0.8386
Loa Loa (eye worm) hypothetical protein 0.0132 0.0585 0.0585
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0045 0.0081 0.0081
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0078 0.0272 0.0688
Loa Loa (eye worm) hypothetical protein 0.0929 0.5197 0.5197
Brugia malayi Cathepsin L-like precursor 0.0347 0.1828 0.1828
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0132 0.0585 0.209
Echinococcus multilocularis inhibitor of apoptosis protein 0.0041 0.0056 0.0056
Brugia malayi calpain D 0.0136 0.0609 0.0609
Trypanosoma brucei cysteine peptidase, putative 0.0136 0.0609 0.1661
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.1661
Echinococcus granulosus cathepsin L 0.0278 0.1432 0.1432
Brugia malayi Cathepsin L-like precursor 0.0493 0.2674 0.2674
Echinococcus multilocularis centrin 2 0.0078 0.0272 0.0272
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0034 0.0034
Trypanosoma brucei calpain-like protein, putative 0.0472 0.2552 0.7272
Loa Loa (eye worm) hypothetical protein 0.0132 0.0585 0.0585
Entamoeba histolytica cysteine protease, putative 0.0132 0.0585 0.1306
Onchocerca volvulus 0.0037 0.0034 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0585 0.1593
Onchocerca volvulus 0.0079 0.028 0.0635
Schistosoma mansoni gamma-secretase subunit aph-1 0.0244 0.1231 0.1231
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.1661
Brugia malayi Trypsin family protein 0.0032 0.0007 0.0007
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0136 0.0609 0.1661
Entamoeba histolytica cysteine protease, putative 0.0278 0.1432 0.483
Trichomonas vaginalis calpain, putative 0.0136 0.0609 0.1661
Brugia malayi programmed cell death protein 6 0.0078 0.0272 0.0272
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0132 0.0585 0.0585
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0493 0.2674 0.7625
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0136 0.0609 0.0577
Toxoplasma gondii preprocathepsin c precursor, putative 0.0132 0.0585 0.1593
Plasmodium vivax hypothetical protein, conserved 0.0079 0.028 0.0933
Plasmodium falciparum serine repeat antigen 1 0.0132 0.0585 0.1306
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0136 0.0609 0.0577
Echinococcus multilocularis calpain 7 (C02 family) 0.0472 0.2552 0.2552
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0078 0.0272 0.0902
Trypanosoma brucei hypothetical protein 0.0136 0.0609 0.1661
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0493 0.2674 0.7625
Echinococcus granulosus EF HAND 1 calcium binding site 0.0078 0.0272 0.0272
Echinococcus multilocularis hypothetical protein 0.0472 0.2552 0.2552
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0132 0.0585 0.209
Echinococcus granulosus EF hand domain containing family member A2 0.0079 0.028 0.028
Brugia malayi Papain family cysteine protease containing protein 0.0132 0.0585 0.0585
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0493 0.2674 0.7625
Schistosoma mansoni ef hand domain family member A2 0.0078 0.0272 0.0272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0493 0.2674 0.7625
Leishmania major kinesin, putative 0.0336 0.1765 0.4999
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.1661
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0472 0.2552 0.2527
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0539 0.2938 0.8386
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0493 0.2674 0.7625
Entamoeba histolytica cysteine protease, putative 0.0278 0.1432 0.483
Schistosoma mansoni hypothetical protein 0.0041 0.0056 0.0056
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0272 0.0688
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0539 0.2938 0.8386
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0091 0.0091
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0635 0.3497 0.3475
Trypanosoma brucei calpain-like protein, putative 0.0472 0.2552 0.7272
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0585 0.1593
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0132 0.0585 0.209
Leishmania major calmodulin-like protein 0.0078 0.0272 0.0688
Giardia lamblia Cathepsin B precursor 0.0132 0.0585 0.0949
Giardia lamblia Cathepsin B precursor 0.0132 0.0585 0.0949
Brugia malayi cathepsin Z-like cysteine proteinase 0.0132 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0347 0.1828 0.1828
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0136 0.0609 0.0577
Entamoeba histolytica cysteine proteinase, putative 0.0278 0.1432 0.483
Onchocerca volvulus 0.0032 0.0007 0.0016
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0136 0.0609 0.0577
Onchocerca volvulus 0.0037 0.0034 0.0076
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0472 0.2552 0.2527
Echinococcus granulosus cysteine protease 0.0278 0.1432 0.1432
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1343 0.7591 0.7591
Echinococcus granulosus cathepsin L cysteine protease 0.0278 0.1432 0.1432
Entamoeba histolytica protein kinase, putative 0.0336 0.1765 0.6215
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0272 0.0688
Echinococcus multilocularis cathepsin L cysteine protease 0.0493 0.2674 0.2674
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.0585 0.1593
Entamoeba histolytica cysteine protease, putative 0.0278 0.1432 0.483
Loa Loa (eye worm) calpain D 0.0136 0.0609 0.0609
Loa Loa (eye worm) calpain family protein 1 0.0929 0.5197 0.5197
Loa Loa (eye worm) hypothetical protein 0.0043 0.007 0.007
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0032 0.0007 0.0007
Onchocerca volvulus 0.0032 0.0007 0.0016
Trypanosoma cruzi cysteine proteinase, putative 0.0278 0.1432 0.1403
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0493 0.2674 0.7625
Loa Loa (eye worm) hypothetical protein 0.0132 0.0585 0.0585
Entamoeba histolytica calpain large subunit domain III containing protein 0.0336 0.1765 0.6215
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0132 0.0585 0.1306
Trichomonas vaginalis calmodulin, putative 0.0078 0.0272 0.0688
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0472 0.2552 0.2527
Entamoeba histolytica cysteine protease, putative 0.0132 0.0585 0.1306
Loa Loa (eye worm) hypothetical protein 0.0045 0.0082 0.0082
Giardia lamblia Cysteine protease 0.0132 0.0585 0.0949
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0041 0.0056 0.0056
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1759 1 1
Trichomonas vaginalis calcium binding protein, putative 0.0078 0.0272 0.0688
Trypanosoma brucei I/6 autoantigen 0.0078 0.0272 0.0688
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0493 0.2674 0.7625
Giardia lamblia Cathepsin B precursor 0.0635 0.3497 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0132 0.0585 0.209
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0136 0.0609 0.0577
Entamoeba histolytica cysteine proteinase, putative 0.0493 0.2674 1
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0609 0.1661
Giardia lamblia Cathepsin L precursor 0.0132 0.0585 0.0949
Brugia malayi Trypsin family protein 0.0032 0.0007 0.0007
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0059 0.0162 0.0129
Brugia malayi Papain family cysteine protease containing protein 0.0132 0.0585 0.0585
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0136 0.0609 0.0577
Toxoplasma gondii cathepsin CPL 0.0493 0.2674 0.7625
Giardia lamblia Cysteine protease 0.0132 0.0585 0.0949
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0078 0.0272 0.0272
Entamoeba histolytica cysteine protease, putative 0.0278 0.1432 0.483
Brugia malayi beta-lactamase family protein 0.0037 0.0034 0.0034

Activities

Activity type Activity value Assay description Source Reference
I50 (binding) = 0.26 mM Effect on Acetylcholinesterase activity in rat erythrocytes ChEMBL. 3965704
I50 (binding) = 0.26 mM Effect on Acetylcholinesterase activity in rat brain homogenates ChEMBL. 3965704
IC50 (binding) = 0.26 mM Effect on Acetylcholinesterase activity in rat erythrocytes ChEMBL. 3965704
IC50 (binding) = 0.26 mM Effect on Acetylcholinesterase activity in rat brain homogenates ChEMBL. 3965704
Rate constant (ADMET) = 0.0359 Compound (1 mM) was evaluated in vitro for the effect on rate of aging(rate constant) of Soman-inhibited rat erythrocyte AChE and first order rate constant was determined ChEMBL. 3965704
Ratio (functional) = 1.19 Ratio of control/treated value of the compound ChEMBL. 3965704

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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