Detailed information for compound 15967

Basic information

Technical information
  • TDR Targets ID: 15967
  • Name: 4-(4-chlorophenyl)-6-methyl-5,7-dihydro-4H-th ieno[2,3-c]pyridin-2-amine
  • MW: 278.8 | Formula: C14H15ClN2S
  • H donors: 1 H acceptors: 0 LogP: 3.24 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1Cc2sc(cc2C(C1)c1ccc(cc1)Cl)N
  • InChi: 1S/C14H15ClN2S/c1-17-7-12(9-2-4-10(15)5-3-9)11-6-14(16)18-13(11)8-17/h2-6,12H,7-8,16H2,1H3
  • InChiKey: XBQLTAVVMUKUQK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-(4-chlorophenyl)-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]amine
  • 4-(4-chlorophenyl)-6-methyl-5,7-dihydro-4H-thieno[4,5-d]pyridin-2-amine
  • [4-(4-chlorophenyl)-6-methyl-5,7-dihydro-4H-thieno[4,5-d]pyridin-2-yl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0153 0.0577 0.1652
Trypanosoma cruzi I/6 autoantigen, putative 0.0086 0.0241 0.0241
Leishmania major cathepsin L-like protease 0.0571 0.2649 0.7587
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0153 0.0577 0.2177
Leishmania major cathepsin L-like protease 0.0571 0.2649 0.7587
Trypanosoma brucei calpain-like protein, putative 0.0536 0.2474 0.7088
Loa Loa (eye worm) hypothetical protein 0.0153 0.0577 0.0577
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.1679
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0536 0.2474 0.2474
Brugia malayi Cathepsin L-like cysteine proteinase 0.0401 0.1809 0.1809
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0086 0.0241 0.0692
Loa Loa (eye worm) calpain 5 0.038 0.1704 0.1704
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2877 0.8241
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0571 0.2649 0.7587
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0241 0.0692
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.0586
Mycobacterium ulcerans hypothetical protein 0.0041 0.0021 0.0222
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0153 0.0577 0.2177
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0153 0.0577 0.2177
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0153 0.0577 0.0577
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.1679
Echinococcus multilocularis Mastin 0.0041 0.0021 0.0021
Trypanosoma brucei I/6 autoantigen 0.0086 0.0241 0.0692
Brugia malayi Papain family cysteine protease containing protein 0.0571 0.2649 0.2649
Echinococcus granulosus Dipeptidyl peptidase 9 0.0169 0.0654 0.0654
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0021 0.0021
Trypanosoma cruzi calmodulin, putative 0.0086 0.0241 0.0241
Trypanosoma brucei calpain-like protein, putative 0.0536 0.2474 0.7088
Loa Loa (eye worm) hypothetical protein 0.0153 0.0577 0.0577
Plasmodium falciparum serine repeat antigen 8 0.0153 0.0577 0.1485
Giardia lamblia Cathepsin L precursor 0.0153 0.0577 0.1103
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0169 0.0656 0.0656
Echinococcus granulosus cathepsin L 0.0322 0.1417 0.1417
Echinococcus granulosus prolyl endopeptidase 0.0534 0.2466 0.2466
Leishmania major cathepsin L-like protease 0.0617 0.2877 0.8241
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0086 0.0241 0.0107
Echinococcus multilocularis microtubule associated protein 2 0.0675 0.3166 0.3166
Schistosoma mansoni calpain-7 (C02 family) 0.0536 0.2474 0.2474
Echinococcus multilocularis transmembrane protease serine 3 0.0041 0.0021 0.0021
Entamoeba histolytica cysteine protease, putative 0.0153 0.0577 0.1485
Giardia lamblia Cathepsin B precursor 0.0153 0.0577 0.1103
Brugia malayi calcium-binding protein 0.0086 0.0241 0.0241
Onchocerca volvulus 0.0571 0.2649 0.6198
Echinococcus multilocularis calpain family protein 1, d 0.1053 0.5044 0.5044
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0155 0.0586 0.0586
Loa Loa (eye worm) hypothetical protein 0.0153 0.0577 0.0577
Leishmania major kinesin, putative 0.038 0.1704 0.4882
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0041 0.0019 0.0019
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0045 0.0041 0.0041
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0397 0.1788 0.1788
Schistosoma mansoni calmodulin related calcium binding protein 0.0086 0.0241 0.0241
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0155 0.0586 0.1679
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0571 0.2649 0.7587
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0045 0.0041 0.0041
Schistosoma mansoni neuronal calcium sensor 0.0086 0.0241 0.0241
Trypanosoma brucei hypothetical protein 0.0155 0.0586 0.1679
Loa Loa (eye worm) prolyl oligopeptidase 0.0397 0.1788 0.1788
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0536 0.2474 0.2474
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.1519 0.7357 0.7357
Trypanosoma cruzi kinesin, putative 0.038 0.1704 0.1704
Echinococcus granulosus cathepsin l1 0.0401 0.1809 0.1809
Brugia malayi hypothetical protein 0.0088 0.0255 0.0255
Trypanosoma brucei calmodulin, putative 0.0086 0.0241 0.0692
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0153 0.0577 0.1652
Schistosoma mansoni cathepsin F (C01 family) 0.0571 0.2649 0.2649
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.0586
Entamoeba histolytica calpain family cysteine protease, putative 0.0155 0.0586 0.1524
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0155 0.0586 0.1679
Trypanosoma cruzi centrin-3 0.0089 0.026 0.026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0571 0.2649 0.7587
Trypanosoma brucei cysteine peptidase C (CPC) 0.074 0.3491 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0153 0.0577 0.1652
Echinococcus multilocularis cysteine protease 0.0571 0.2649 0.2649
Schistosoma mansoni centrin-related 0.0086 0.0241 0.0241
Echinococcus granulosus Tolloid protein 1 0.0045 0.0041 0.0041
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0153 0.0577 0.1103
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.1679
Echinococcus granulosus acylamino acid releasing enzyme 0.008 0.0215 0.0215
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0322 0.1417 0.1417
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0041 0.0019 0.0019
Trypanosoma brucei caltractin, putative 0.0089 0.026 0.0744
Trypanosoma cruzi centrin, putative 0.0089 0.026 0.026
Brugia malayi cathepsin Z-like cysteine proteinase 0.0153 0.0577 0.0577
Entamoeba histolytica cysteine proteinase, putative 0.0401 0.1809 0.6548
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.1679
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0536 0.2474 0.2474
Schistosoma mansoni neuronal calcium sensor 0.0086 0.0241 0.0241
Echinococcus multilocularis cathepsin b 0.2052 1 1
Schistosoma mansoni hypothetical protein 0.0086 0.0241 0.0241
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0155 0.0586 0.0586
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.1679
Trichomonas vaginalis calmodulin, putative 0.0086 0.0241 0.0692
Echinococcus granulosus calpain 7 C02 family 0.0536 0.2474 0.2474
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0571 0.2649 0.7587
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0153 0.0577 0.0577
Entamoeba histolytica cysteine proteinase, putative 0.0571 0.2649 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0153 0.0577 0.0577
Echinococcus multilocularis prolyl endopeptidase 0.0534 0.2466 0.2466
Onchocerca volvulus 0.0571 0.2649 0.6198
Trypanosoma brucei mitochondrial calcium uptake 1 0.0086 0.0241 0.0692
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0536 0.2474 0.2474
Entamoeba histolytica cysteine protease, putative 0.0153 0.0577 0.1485
Leishmania major centrin, putative 0.0086 0.0241 0.0692
Schistosoma mansoni hypothetical protein 0.0041 0.0021 0.0021
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0086 0.0241 0.0241
Trypanosoma cruzi cruzipain precursor, putative 0.0617 0.2877 0.2877
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0086 0.0241 0.0241
Echinococcus granulosus neurocalcin 0.0086 0.0241 0.0241
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0021 0.0021
Trypanosoma brucei oligopeptidase b 0.0229 0.0952 0.2726
Trypanosoma cruzi caltractin, putative 0.0086 0.0241 0.0241
Echinococcus granulosus EF hand domain containing family member A2 0.0087 0.0249 0.0249
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0571 0.2649 0.2649
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0536 0.2474 0.7088
Echinococcus multilocularis cathepsin L 0.0322 0.1417 0.1417
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0155 0.0586 0.0586
Brugia malayi cathepsin L-like cysteine proteinase 0.0153 0.0577 0.0577
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0571 0.2649 0.7587
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0153 0.0577 0.2177
Brugia malayi calpain family protein 1 0.1434 0.6932 0.6932
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0401 0.1809 0.1809
Trichomonas vaginalis hypothetical protein 0.0155 0.0586 0.1679
Loa Loa (eye worm) hypothetical protein 0.1053 0.5044 0.5044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2877 0.8241
Echinococcus granulosus EF hand domain containing family member A2 0.0086 0.0241 0.0241
Schistosoma mansoni rab 0.0086 0.0241 0.0241
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0086 0.0241 0.0241
Giardia lamblia Cathepsin B precursor 0.0153 0.0577 0.1103
Loa Loa (eye worm) calpain family protein 1 0.1053 0.5044 0.5044
Brugia malayi cathepsin L-like precursor 0.0401 0.1809 0.1809
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.005 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0322 0.1417 0.4058
Echinococcus multilocularis cathepsin L cysteine protease 0.0571 0.2649 0.2649
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0229 0.0952 0.2726
Plasmodium vivax unspecified product 0.0322 0.1417 0.5348
Giardia lamblia Hypothetical protein 0.0153 0.0577 0.1103
Echinococcus granulosus cathepsin b 0.2052 1 1
Entamoeba histolytica cysteine protease, putative 0.0322 0.1417 0.4937
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2877 0.8241
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.1679
Echinococcus granulosus cathepsin L 0.0153 0.0577 0.0577
Entamoeba histolytica cysteine protease, putative 0.0322 0.1417 0.4937
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0155 0.0586 0.0586
Brugia malayi Trypsin family protein 0.0041 0.0021 0.0021
Schistosoma mansoni calpain-2 (C02 family) 0.0155 0.0586 0.0586
Brugia malayi Papain family cysteine protease containing protein 0.0322 0.1417 0.1417
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0155 0.0586 0.0586
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.0586
Brugia malayi Cathepsin L-like precursor 0.0571 0.2649 0.2649
Leishmania major calmodulin, putative 0.0086 0.0241 0.0692
Giardia lamblia Encystation-specific protease 0.0153 0.0577 0.1103
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0169 0.0656 0.0656
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0169 0.0654 0.0654
Plasmodium falciparum cysteine proteinase falcipain 1 0.0322 0.1417 0.4937
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.0586
Trypanosoma brucei calmodulin, putative 0.0087 0.0249 0.0712
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0215 0.0215
Brugia malayi Cathepsin L-like precursor 0.0571 0.2649 0.2649
Toxoplasma gondii EFHC1, putative 0.0086 0.0241 0.0692
Trypanosoma brucei calpain-like protein, putative 0.0536 0.2474 0.7088
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0155 0.0586 0.1679
Toxoplasma gondii hypothetical protein 0.0155 0.0586 0.1679
Toxoplasma gondii hypothetical protein 0.008 0.0215 0.0617
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2877 0.8241
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0169 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0169 0.0656 0.0656
Trypanosoma cruzi cruzipain precursor, putative 0.0169 0.0656 0.0656
Trypanosoma cruzi cysteine peptidase, putative 0.0617 0.2877 0.2877
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.005 0.005
Trypanosoma cruzi cysteine peptidase, putative 0.0322 0.1417 0.1417
Brugia malayi prolyl oligopeptidase family protein 0.0169 0.0654 0.0654
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.005 0.005
Echinococcus multilocularis inhibitor of apoptosis protein 0.0041 0.0019 0.0019
Schistosoma mansoni ef hand domain family member A2 0.0086 0.0241 0.0241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0322 0.1417 0.4058
Loa Loa (eye worm) hypothetical protein 0.0086 0.0241 0.0241
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.005 0.005
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0086 0.0241 0.0241
Plasmodium falciparum centrin-1 0.0086 0.0241 0.0107
Brugia malayi gamma-secretase subunit aph-1 0.0246 0.1037 0.1037
Leishmania major calcineurin B subunit, putative 0.0086 0.0241 0.0692
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.1679
Onchocerca volvulus 0.0041 0.0021 0.0049
Entamoeba histolytica cysteine proteinase, putative 0.0322 0.1417 0.4937
Echinococcus multilocularis calcium uptake protein 1 0.0087 0.0249 0.0249
Trichomonas vaginalis calmodulin, putative 0.0086 0.0241 0.0692
Trichomonas vaginalis calpain, putative 0.0155 0.0586 0.1679
Loa Loa (eye worm) hypothetical protein 0.1279 0.6162 0.6162
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0086 0.0241 0.0241
Trypanosoma brucei Calpain-like protein 1.2 0.0155 0.0586 0.1679
Schistosoma mansoni calpain C (C02 family) 0.0536 0.2474 0.2474
Loa Loa (eye worm) hypothetical protein 0.0898 0.4274 0.4274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.2649 0.7587
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0155 0.0586 0.1679
Echinococcus granulosus cathepsin b 0.2052 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0571 0.2649 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0019 0.0019
Plasmodium falciparum serine repeat antigen 5 0.0153 0.0577 0.1485
Trypanosoma cruzi cysteine peptidase, putative 0.0169 0.0656 0.0656
Echinococcus granulosus centrin 2 0.0086 0.0241 0.0241
Trypanosoma cruzi cysteine peptidase, putative 0.0617 0.2877 0.2877
Trypanosoma cruzi Aph-1 protein, putative 0.0096 0.0292 0.0292
Echinococcus multilocularis neurocalcin 0.0086 0.0241 0.0241
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0155 0.0586 0.1679
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0169 0.0654 0.1874
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0153 0.0577 0.1652
Echinococcus granulosus microtubule associated protein 2 0.0675 0.3166 0.3166
Brugia malayi cathepsin Z-like cysteine proteinase 0.0153 0.0577 0.0577
Onchocerca volvulus 0.0571 0.2649 0.6198
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0229 0.0952 0.4604
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0155 0.0586 0.1679
Trypanosoma cruzi calmodulin, putative 0.0086 0.0241 0.0241
Giardia lamblia Cathepsin L precursor 0.0153 0.0577 0.1103
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1519 0.7357 0.7357
Trypanosoma brucei protein I/6 0.0086 0.0241 0.0692
Echinococcus multilocularis calpain 7 (C02 family) 0.0536 0.2474 0.2474
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0155 0.0586 0.1679
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.2649 0.7587
Trypanosoma brucei Calpain-like protein 2 0.0155 0.0586 0.1679
Toxoplasma gondii EF hand domain-containing protein 0.0086 0.0241 0.0692
Loa Loa (eye worm) cysteine protease 0.0571 0.2649 0.2649
Brugia malayi hypothetical protein 0.0041 0.0021 0.0021
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0041 0.0021 0.0021
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.1679
Toxoplasma gondii centrin 0.0086 0.0241 0.0692
Loa Loa (eye worm) hypothetical protein 0.0041 0.0019 0.0019
Schistosoma mansoni calmodulin 0.0086 0.0241 0.0241
Leishmania major centrin, putative,caltractin, putative 0.0086 0.0241 0.0692
Echinococcus granulosus calcium uptake protein 1 0.0087 0.0249 0.0249
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0322 0.1417 0.1417
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0021 0.0021
Entamoeba histolytica cysteine protease, putative 0.0322 0.1417 0.4937
Entamoeba histolytica cysteine proteinase, putative 0.0322 0.1417 0.4937
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0153 0.0577 0.2177
Loa Loa (eye worm) cathepsin B 0.074 0.3491 0.3491
Schistosoma mansoni neuronal calcium sensor 0.0086 0.0241 0.0241
Trypanosoma cruzi conserved protein 0.0155 0.0586 0.0586
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.008 0.0215 0.0215
Echinococcus multilocularis centrin 2 0.0086 0.0241 0.0241
Plasmodium vivax unspecified product 0.0153 0.0577 0.2177
Trichomonas vaginalis conserved hypothetical protein 0.0153 0.0577 0.1652
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0215 0.0617
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0534 0.2466 0.2466
Entamoeba histolytica calcium-binding protein, putative 0.0086 0.0241 0.0107
Toxoplasma gondii calcium-dependent protein kinase 0.0087 0.0249 0.0712
Brugia malayi Papain family cysteine protease containing protein 0.0153 0.0577 0.0577
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.008 0.0215 0.0617
Toxoplasma gondii centrin, putative 0.0086 0.0241 0.0692
Trypanosoma cruzi cysteine proteinase, putative 0.0322 0.1417 0.1417
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.1679
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.1679
Leishmania major phospholipase c-like protein 0.0086 0.0241 0.0692
Entamoeba histolytica cysteine protease, putative 0.0153 0.0577 0.1485
Echinococcus granulosus calbindin 32 0.0087 0.0249 0.0249
Brugia malayi Trypsin-like protease protein 5 0.0041 0.0021 0.0021
Echinococcus multilocularis calmodulin 0.0086 0.0241 0.0241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.2649 0.7587
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0377 0.1689 0.1689
Entamoeba histolytica calmodulin, putative 0.0086 0.0241 0.0107
Echinococcus granulosus calmodulin 0.0086 0.0241 0.0241
Trypanosoma cruzi prolyl endopeptidase 0.0534 0.2466 0.2466
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0571 0.2649 0.2649
Echinococcus granulosus gamma secretase subunit aph 1 0.0246 0.1037 0.1037
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0021 0.0021
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.099 0.4791
Giardia lamblia Cysteine protease 0.0153 0.0577 0.1103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0153 0.0577 0.1652
Echinococcus granulosus calpain 0.0536 0.2474 0.2474
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0153 0.0577 0.1652
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.0586
Brugia malayi Papain family cysteine protease containing protein 0.0153 0.0577 0.0577
Schistosoma mansoni reticulocalbin 0.0087 0.0249 0.0249
Plasmodium vivax hypothetical protein, conserved 0.008 0.0215 0.0813
Giardia lamblia Cathepsin L-like protease 0.0153 0.0577 0.1103
Brugia malayi prolyl oligopeptidase family protein 0.0534 0.2466 0.2466
Schistosoma mansoni cathepsin C 0.0153 0.0577 0.0577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.2649 0.7587
Trypanosoma cruzi cysteine proteinase, putative 0.0322 0.1417 0.1417
Entamoeba histolytica cysteine proteinase 1, putative 0.0322 0.1417 0.4937
Echinococcus granulosus calpain 5 0.0536 0.2474 0.2474
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2877 0.8241
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.0021
Entamoeba histolytica cysteine protease, putative 0.0322 0.1417 0.4937
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0397 0.1788 0.1788
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.0586
Brugia malayi calpain D 0.0155 0.0586 0.0586
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0155 0.0586 0.0586
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0086 0.0241 0.0241
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.1679
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0032
Onchocerca volvulus Cathepsin L homolog 0.0153 0.0577 0.1349
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0021 0.0021
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0086 0.0241 0.0241
Brugia malayi cathepsin F-like cysteine proteinase 0.0169 0.0656 0.0656
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0153 0.0577 0.1485
Echinococcus granulosus cathepsin L cysteine proteinase 0.0571 0.2649 0.2649
Trypanosoma cruzi cysteine protease, putative 0.0322 0.1417 0.1417
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0534 0.2466 0.2466
Loa Loa (eye worm) hypothetical protein 0.008 0.0215 0.0215
Leishmania major hypothetical protein, conserved 0.0087 0.0249 0.0712
Entamoeba histolytica cysteine protease, putative 0.0153 0.0577 0.1485
Loa Loa (eye worm) hypothetical protein 0.0169 0.0656 0.0656
Leishmania major cysteine peptidase A (CPA) 0.0571 0.2649 0.7587
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0153 0.0577 0.0577
Brugia malayi Papain family cysteine protease containing protein 0.0322 0.1417 0.1417
Loa Loa (eye worm) hypothetical protein 0.0088 0.0255 0.0255
Entamoeba histolytica cysteine protease, putative 0.0322 0.1417 0.4937
Entamoeba histolytica hypothetical protein, conserved 0.0087 0.0249 0.0137
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0536 0.2474 0.2474
Trichomonas vaginalis calmodulin, putative 0.0086 0.0241 0.0692
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0536 0.2474 0.7088
Brugia malayi calpain 5 0.0155 0.0586 0.0586
Trichomonas vaginalis calmodulin, putative 0.0087 0.0249 0.0712
Giardia lamblia Cysteine protease 0.0153 0.0577 0.1103
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0153 0.0577 0.1103
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0153 0.0577 0.1485
Giardia lamblia Cathepsin L precursor 0.0153 0.0577 0.1103
Trypanosoma brucei centrin, putative 0.0086 0.0241 0.0692
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0571 0.2649 0.2649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0322 0.1417 0.4058
Echinococcus granulosus inhibitor of apoptosis protein 0.0041 0.0019 0.0019
Leishmania major cathepsin L-like protease 0.0617 0.2877 0.8241
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0153 0.0577 0.0577
Brugia malayi prolyl oligopeptidase family protein 0.008 0.0215 0.0215
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0169 0.0654 0.1874
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0086 0.0241 0.0911
Giardia lamblia Cathepsin B precursor 0.0153 0.0577 0.1103
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0241 0.0692
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0322 0.1417 0.1417
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0155 0.0586 0.0586
Onchocerca volvulus 0.0041 0.0021 0.0049
Loa Loa (eye worm) hypothetical protein 0.0571 0.2649 0.2649
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0153 0.0577 0.1103
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2052 1 1
Trypanosoma brucei prolyl oligopeptidase, putative 0.0229 0.0952 0.2726
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0153 0.0577 0.0577
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2877 0.8241
Toxoplasma gondii calmodulin CAM1 0.0087 0.0249 0.0712
Echinococcus granulosus enteropeptidase 0.0041 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0571 0.2649 0.7587
Onchocerca volvulus 0.0087 0.0249 0.0582
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0041 0.0019 0.0019
Loa Loa (eye worm) EF hand family protein 0.0086 0.0241 0.0241
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0041 0.0019 0.0019
Trypanosoma cruzi oligopeptidase b 0.0229 0.0952 0.0952
Loa Loa (eye worm) hypothetical protein 0.0086 0.0241 0.0241
Onchocerca volvulus Cathepsin L homolog 0.0571 0.2649 0.6198
Brugia malayi Cathepsin L-like precursor 0.0401 0.1809 0.1809
Trypanosoma cruzi cysteine peptidase, putative 0.0571 0.2649 0.2649
Trypanosoma brucei centrin-3 0.0089 0.026 0.0744
Schistosoma mansoni Mername-AA248 (C02 family) 0.0536 0.2474 0.2474
Trypanosoma brucei hypothetical protein, conserved 0.0086 0.0241 0.0692
Echinococcus granulosus calpain A 0.0536 0.2474 0.2474
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0021 0.0021
Loa Loa (eye worm) prolyl oligopeptidase 0.008 0.0215 0.0215
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.1519 0.7357 0.7357
Trypanosoma cruzi kinesin, putative 0.038 0.1704 0.1704
Trichomonas vaginalis calmodulin, putative 0.0086 0.0241 0.0692
Leishmania major cathepsin L-like protease 0.0571 0.2649 0.7587
Loa Loa (eye worm) trypsin family protein 0.0041 0.0021 0.0021
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0155 0.0586 0.1679
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0571 0.2649 1
Entamoeba histolytica grainin 2 0.0089 0.026 0.0182
Leishmania major protein kinase, putative 0.0086 0.0241 0.0692
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0155 0.0586 0.1679
Trichomonas vaginalis calpain, putative 0.0155 0.0586 0.1679
Schistosoma mansoni reticulocalbin 0.0086 0.0241 0.0241
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0153 0.0577 0.2177
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0153 0.0577 0.2177
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.0021
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0086 0.0241 0.0241
Loa Loa (eye worm) ctsf protein 0.0571 0.2649 0.2649
Loa Loa (eye worm) calpain family protein 1 0.1434 0.6932 0.6932
Echinococcus multilocularis calumenin 0.0087 0.0249 0.0249
Schistosoma mansoni cathepsin F (C01 family) 0.0571 0.2649 0.2649
Echinococcus multilocularis calpain 0.0536 0.2474 0.2474
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0153 0.0577 0.0577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0401 0.1809 0.5181
Leishmania major cathepsin L-like protease 0.0571 0.2649 0.7587
Trichomonas vaginalis calmodulin, putative 0.0086 0.0241 0.0692
Brugia malayi Cathepsin L-like precursor 0.0571 0.2649 0.2649
Plasmodium falciparum serine repeat antigen 7 0.0153 0.0577 0.1485
Onchocerca volvulus 0.0041 0.0021 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.2649 0.7587
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2877 0.8241
Trypanosoma cruzi oligopeptidase b 0.0229 0.0952 0.0952
Trypanosoma brucei calpain, putative 0.0155 0.0586 0.1679
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0153 0.0577 0.1652
Brugia malayi Cathepsin L-like precursor 0.0169 0.0656 0.0656
Trypanosoma brucei Calpain-like protein 1.1 0.0155 0.0586 0.1679
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0169 0.0654 0.1874
Leishmania major hypothetical protein, conserved 0.0086 0.0241 0.0692
Onchocerca volvulus 0.0041 0.0021 0.0049
Schistosoma mansoni centrin 0.0086 0.0241 0.0241
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.1679
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0155 0.0586 0.0586
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0021 0.0021
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0021 0.0021
Brugia malayi Cathepsin L-like precursor 0.0401 0.1809 0.1809
Echinococcus granulosus cathepsin l cysteine peptidase 0.0571 0.2649 0.2649
Entamoeba histolytica cysteine protease, putative 0.0153 0.0577 0.1485
Schistosoma mansoni calpain (C02 family) 0.0536 0.2474 0.2474
Brugia malayi calpain family protein 1 0.1434 0.6932 0.6932
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1434 0.6932 0.6932
Schistosoma mansoni hypothetical protein 0.0155 0.0586 0.0586
Schistosoma mansoni calpain-7 (C02 family) 0.0536 0.2474 0.2474
Toxoplasma gondii cathepsin CPC2 0.0153 0.0577 0.1652
Entamoeba histolytica cysteine protease, putative 0.0322 0.1417 0.4937
Loa Loa (eye worm) hypothetical protein 0.0401 0.1809 0.1809
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.005 0.005
Onchocerca volvulus Prolyl endopeptidase homolog 0.0534 0.2466 0.577
Schistosoma mansoni cathepsin s 0.0169 0.0656 0.0656
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2877 0.8241
Giardia lamblia Hypothetical protein 0.0087 0.0249 0.0101
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.1679
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0536 0.2474 0.7088
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0153 0.0577 0.2177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.2649 0.7587
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0153 0.0577 0.1485
Onchocerca volvulus 0.0086 0.0241 0.0565
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0021 0.0021
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1519 0.7357 0.7357
Schistosoma mansoni microtubule-associated protein tau 0.0675 0.3166 0.3166
Entamoeba histolytica calmodulin, putative 0.0086 0.0241 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.2649 0.7587
Trypanosoma brucei Aph-1 protein, putative 0.0096 0.0292 0.0836
Plasmodium falciparum serine repeat antigen 6 0.0153 0.0577 0.1485
Loa Loa (eye worm) hypothetical protein 0.0534 0.2466 0.2466
Onchocerca volvulus 0.0086 0.0241 0.0565
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0153 0.0577 0.1652
Brugia malayi prolyl oligopeptidase family protein 0.0397 0.1788 0.1788
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0153 0.0577 0.0577
Trypanosoma brucei kinesin, putative 0.038 0.1704 0.4882
Entamoeba histolytica hypothetical protein 0.0153 0.0577 0.1485
Brugia malayi Cathepsin L-like precursor 0.0571 0.2649 0.2649
Toxoplasma gondii cathepsin CPC1 0.0153 0.0577 0.1652
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0155 0.0586 0.1679
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0169 0.0654 0.0654
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0536 0.2474 0.2474
Giardia lamblia Cathepsin L-like protease 0.0153 0.0577 0.1103
Echinococcus multilocularis programmed cell death protein 0.0089 0.026 0.026
Giardia lamblia Cathepsin B precursor 0.074 0.3491 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2877 0.8241
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0571 0.2649 0.7587
Brugia malayi Trypsin family protein 0.0041 0.0021 0.0021
Brugia malayi fibroinase precursor 0.0153 0.0577 0.0577
Trypanosoma cruzi I/6 autoantigen, putative 0.0086 0.0241 0.0241
Schistosoma mansoni hypothetical protein 0.0041 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.0021
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0322 0.1417 0.1417
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.005 0.005
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0021 0.0021
Onchocerca volvulus 0.0898 0.4274 1
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0087 0.0249 0.0249
Leishmania major cathepsin L-like protease 0.0617 0.2877 0.8241
Trypanosoma cruzi centrin, putative 0.0089 0.026 0.026
Entamoeba histolytica cysteine protease, putative 0.0322 0.1417 0.4937
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0086 0.0241 0.0692
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0571 0.2649 0.7587
Trypanosoma brucei calpain, putative 0.0155 0.0586 0.1679
Onchocerca volvulus 0.0571 0.2649 0.6198
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.008 0.0215 0.0215
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0041 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.2649 0.7587
Schistosoma mansoni inhibitor of apoptosis protein 0.0041 0.0019 0.0019
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.0586
Entamoeba histolytica calcium binding family protein 0.0086 0.0241 0.0107
Loa Loa (eye worm) hypothetical protein 0.008 0.0215 0.0215
Onchocerca volvulus Cathepsin F homolog 0.0571 0.2649 0.6198
Trichomonas vaginalis myosin light chain 1, putative 0.0086 0.0241 0.0692
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0169 0.0656 0.0656
Brugia malayi Papain family cysteine protease containing protein 0.0153 0.0577 0.0577
Plasmodium vivax vivapain-2 0.0571 0.2649 1
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0041 0.0021 0.0021
Echinococcus granulosus cathepsin l1 0.0571 0.2649 0.2649
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.074 0.3491 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0536 0.2474 0.2474
Loa Loa (eye worm) hypothetical protein 0.0153 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.0401 0.1809 0.1809
Schistosoma mansoni hypothetical protein 0.0086 0.0241 0.0241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.2649 0.7587
Echinococcus multilocularis cathepsin L cysteine protease 0.0571 0.2649 0.2649
Echinococcus granulosus EF HAND 1 calcium binding site 0.0086 0.0241 0.0241
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.1679
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0571 0.2649 0.7587
Entamoeba histolytica cysteine protease, putative 0.0322 0.1417 0.4937
Echinococcus granulosus glycoprotein Antigen 5 0.0041 0.0021 0.0021
Leishmania major calmodulin, putative 0.0086 0.0241 0.0692
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.2649 0.7587
Brugia malayi cathepsin F-like cysteine proteinase 0.0153 0.0577 0.0577
Echinococcus multilocularis gamma secretase subunit aph 1 0.0246 0.1037 0.1037
Giardia lamblia Cathepsin B precursor 0.0153 0.0577 0.1103
Entamoeba histolytica grainin, putative 0.0087 0.0249 0.0137
Loa Loa (eye worm) hypothetical protein 0.0155 0.0586 0.0586
Trypanosoma cruzi calmodulin, putative 0.0086 0.0241 0.0241
Brugia malayi Trypsin family protein 0.0041 0.0021 0.0021
Loa Loa (eye worm) fibroinase 0.0571 0.2649 0.2649
Brugia malayi EF hand family protein 0.0087 0.0249 0.0249
Echinococcus multilocularis calmodulin 0.0086 0.0241 0.0241
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0536 0.2474 0.2474
Trichomonas vaginalis calcium binding proteins, putative 0.0086 0.0241 0.0692
Onchocerca volvulus Cathepsin L homolog 0.0571 0.2649 0.6198
Echinococcus multilocularis cysteine protease 0.0571 0.2649 0.2649
Echinococcus multilocularis cathepsin L 0.0153 0.0577 0.0577
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0322 0.1417 0.4058
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0536 0.2474 0.2474
Leishmania major calpain family cysteine protease-like protein 0.0155 0.0586 0.1679
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0153 0.0577 0.1103
Entamoeba histolytica cysteine protease, putative 0.0571 0.2649 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0153 0.0577 0.1652
Giardia lamblia Cathepsin B precursor 0.0153 0.0577 0.1103
Leishmania major i/6 autoantigen-like protein 0.0086 0.0241 0.0692
Trichomonas vaginalis calmodulin-2, putative 0.0086 0.0241 0.0692
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0447 0.2037 0.2037
Entamoeba histolytica cysteine protease, putative 0.0322 0.1417 0.4937
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.008 0.0215 0.0617
Giardia lamblia Cysteine protease 0.0153 0.0577 0.1103
Plasmodium vivax centrin-1, putative 0.0086 0.0241 0.0911
Onchocerca volvulus 0.0041 0.0021 0.0049
Plasmodium vivax serine-repeat antigen (SERA) 0.0153 0.0577 0.2177
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0536 0.2474 0.7088
Brugia malayi prolyl oligopeptidase family protein 0.008 0.0215 0.0215
Onchocerca volvulus 0.0401 0.1809 0.4232
Plasmodium falciparum calpain 0.0155 0.0586 0.1524
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0153 0.0577 0.0577
Onchocerca volvulus 0.0153 0.0577 0.1349
Schistosoma mansoni cathepsin B (C01 family) 0.0153 0.0577 0.0577
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2052 1 1
Trypanosoma brucei prolyl endopeptidase 0.0534 0.2466 0.7063
Entamoeba histolytica cysteine protease, putative 0.0322 0.1417 0.4937
Echinococcus granulosus cysteine protease 0.0322 0.1417 0.1417
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.005 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.2649 0.7587
Trichomonas vaginalis calpain, putative 0.0155 0.0586 0.1679
Plasmodium falciparum serine repeat antigen 3 0.0153 0.0577 0.1485
Brugia malayi cathepsin L precursor 0.0153 0.0577 0.0577
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.0586 0.1679
Leishmania major programmed cell death 6 protein-like protein 0.0086 0.0241 0.0692
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0153 0.0577 0.1485
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.2649 0.7587
Leishmania major calpain protease-like protein 0.0155 0.0586 0.1679
Echinococcus granulosus cathepsin L cysteine protease 0.0322 0.1417 0.1417
Toxoplasma gondii cathepsin CPL 0.0571 0.2649 0.7587
Trichomonas vaginalis calcineurin B subunit, putative 0.0087 0.0249 0.0712
Onchocerca volvulus 0.0571 0.2649 0.6198
Entamoeba histolytica cysteine proteinase, putative 0.0322 0.1417 0.4937
Echinococcus multilocularis EF hand domain containing family member A2 0.0086 0.0241 0.0241
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0169 0.0654 0.1874
Giardia lamblia Cathepsin L precursor 0.0153 0.0577 0.1103
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0086 0.0241 0.0107
Trichomonas vaginalis calmodulin, putative 0.0089 0.026 0.0744
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0153 0.0577 0.1652
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0153 0.0577 0.1652
Trypanosoma brucei calpain-like protein, putative 0.0536 0.2474 0.7088
Loa Loa (eye worm) programmed cell death protein 6 0.0087 0.0249 0.0249
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0229 0.0952 0.0952
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.1679
Echinococcus multilocularis programmed cell death protein 0.0089 0.026 0.026
Echinococcus multilocularis calpain A 0.1521 0.7364 0.7364
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.0586
Toxoplasma gondii cathepsin B 0.074 0.3491 1
Trypanosoma brucei centrin, putative 0.0086 0.0241 0.0692
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2877 0.8241
Mycobacterium tuberculosis Probable peptidase 0.0229 0.0952 0.4604
Brugia malayi Calmodulin-like protein 0.0086 0.0241 0.0241
Trichomonas vaginalis calcium binding protein, putative 0.0089 0.026 0.0744
Plasmodium vivax hypothetical protein, conserved 0.0087 0.0249 0.0939
Loa Loa (eye worm) hypothetical protein 0.2052 1 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0155 0.0586 0.0586
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0397 0.1788 0.1788
Entamoeba histolytica protein kinase, putative 0.038 0.1704 0.612
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0153 0.0577 0.2177
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0153 0.0577 0.1652
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2052 1 1
Giardia lamblia Cathepsin B precursor 0.074 0.3491 1
Leishmania major hypothetical protein, unknown function 0.0155 0.0586 0.1679
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.1679
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0246 0.1037 0.1037
Brugia malayi Trypsin family protein 0.0041 0.0021 0.0021
Schistosoma mansoni cathepsin S (C01 family) 0.0153 0.0577 0.0577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.2649 0.7587
Echinococcus granulosus Mastin 0.0041 0.0021 0.0021
Trichomonas vaginalis centrin, putative 0.0086 0.0241 0.0692
Toxoplasma gondii preprocathepsin c precursor, putative 0.0153 0.0577 0.1652
Entamoeba histolytica cysteine protease, putative 0.0322 0.1417 0.4937
Plasmodium falciparum serine repeat antigen 1 0.0153 0.0577 0.1485
Loa Loa (eye worm) hypothetical protein 0.0153 0.0577 0.0577
Trichomonas vaginalis calcium binding protein, putative 0.0086 0.0241 0.0692
Loa Loa (eye worm) hypothetical protein 0.1434 0.6932 0.6932
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0169 0.0654 0.0654
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0534 0.2466 0.7063
Plasmodium vivax calpain, putative 0.0536 0.2474 0.9342
Echinococcus multilocularis glycoprotein Antigen 5 0.0041 0.0021 0.0021
Brugia malayi programmed cell death protein 6 0.0086 0.0241 0.0241
Leishmania major cathepsin L-like protease 0.0571 0.2649 0.7587
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0229 0.0952 1
Echinococcus multilocularis neuronal calcium sensor 0.0086 0.0241 0.0241
Brugia malayi calpain 5 0.038 0.1704 0.1704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0401 0.1809 0.5181
Schistosoma mansoni cathepsin F (C01 family) 0.0401 0.1809 0.1809
Echinococcus granulosus neuronal calcium sensor 0.0086 0.0241 0.0241
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.1679
Trypanosoma brucei cysteine peptidase, putative 0.0155 0.0586 0.1679
Trypanosoma brucei Calpain-like protein CALP1.3 0.0155 0.0586 0.1679
Leishmania major calmodulin-like protein 0.0086 0.0241 0.0692
Giardia lamblia Cathepsin L precursor 0.0153 0.0577 0.1103
Entamoeba histolytica calpain large subunit domain III containing protein 0.038 0.1704 0.612
Loa Loa (eye worm) calmodulin-like protein 0.0086 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.0021
Entamoeba histolytica cysteine protease, putative 0.0322 0.1417 0.4937
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0086 0.0241 0.0692
Echinococcus multilocularis expressed protein 0.0365 0.1628 0.1628
Entamoeba histolytica cysteine protease, putative 0.0153 0.0577 0.1485
Leishmania major oligopeptidase b 0.0229 0.0952 0.2726
Trypanosoma cruzi major cysteine proteinase, putative 0.0199 0.0805 0.0805
Trypanosoma brucei Component of motile flagella 41 0.0086 0.0241 0.0692
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.2649 0.7587
Entamoeba histolytica cysteine proteinase 2 0.0322 0.1417 0.4937
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0045 0.004 0.004
Toxoplasma gondii prolyl endopeptidase 0.0534 0.2466 0.7063
Echinococcus multilocularis acylamino acid releasing enzyme 0.008 0.0215 0.0215
Toxoplasma gondii troponin c, isotype gamma, putative 0.0086 0.0241 0.0692
Trypanosoma cruzi major cysteine proteinase, putative 0.0153 0.0577 0.0577
Onchocerca volvulus 0.0041 0.0019 0.0045
Trichomonas vaginalis calmodulin, putative 0.0086 0.0241 0.0692
Trichomonas vaginalis calcium binding protein, putative 0.0086 0.0241 0.0692
Echinococcus multilocularis enteropeptidase 0.0041 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0153 0.0577 0.1652
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0155 0.0586 0.0586
Leishmania major hypothetical protein, conserved 0.0155 0.0586 0.1679
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.005 0.005
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0087 0.0249 0.0249
Schistosoma mansoni hypothetical protein 0.0041 0.0019 0.0019
Brugia malayi Cathepsin L-like precursor 0.0571 0.2649 0.2649
Echinococcus multilocularis cathepsin b 0.2052 1 1
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0229 0.0952 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0153 0.0577 0.0577
Entamoeba histolytica cysteine protease, putative 0.0322 0.1417 0.4937
Plasmodium falciparum serine repeat antigen 9 0.0153 0.0577 0.1485
Plasmodium vivax serine-repeat antigen (SERA) 0.0153 0.0577 0.2177
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.1679
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.074 0.3491 0.3491
Brugia malayi Cathepsin L-like precursor 0.0571 0.2649 0.2649
Giardia lamblia Hypothetical protein 0.0153 0.0577 0.1103
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0086 0.0241 0.0241
Giardia lamblia Cysteine protease 0.0153 0.0577 0.1103
Echinococcus granulosus expressed protein 0.0365 0.1628 0.1628
Giardia lamblia Cathepsin B precursor 0.074 0.3491 1
Leishmania major calmodulin-like protein 0.0086 0.0241 0.0692
Echinococcus granulosus programmed cell death protein 0.0089 0.026 0.026
Plasmodium falciparum serine repeat antigen 4 0.0153 0.0577 0.1485
Trypanosoma cruzi cysteine peptidase, putative 0.0617 0.2877 0.2877
Echinococcus multilocularis calbindin 32 0.0087 0.0249 0.0249
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0571 0.2649 0.7587
Echinococcus multilocularis calpain 5 0.0536 0.2474 0.2474
Onchocerca volvulus Deterin homolog 0.0041 0.0019 0.0045
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0153 0.0577 0.1485
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0377 0.1689 0.1689
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0153 0.0577 0.1652
Leishmania major centrin, putative 0.0086 0.0241 0.0692
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2052 1 1
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0453 0.2067 1
Loa Loa (eye worm) calpain 0.0536 0.2474 0.2474
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0153 0.0577 0.0577
Echinococcus granulosus transmembrane protease serine 3 0.0041 0.0021 0.0021
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0153 0.0577 0.0577
Onchocerca volvulus 0.0571 0.2649 0.6198
Trichomonas vaginalis conserved hypothetical protein 0.0153 0.0577 0.1652
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.0021
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0086 0.0241 0.0692
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0155 0.0586 0.1679
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0041 0.0021 0.0021
Trichomonas vaginalis centrin, putative 0.0086 0.0241 0.0692
Plasmodium vivax unspecified product 0.0169 0.0656 0.2478
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.0021
Onchocerca volvulus 0.0571 0.2649 0.6198
Giardia lamblia Cathepsin L precursor 0.0153 0.0577 0.1103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0571 0.2649 0.7587
Loa Loa (eye worm) calpain D 0.0155 0.0586 0.0586
Plasmodium falciparum serine repeat antigen 2 0.0153 0.0577 0.1485
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0571 0.2649 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0153 0.0577 0.1652
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0041 0.0021 0.0021
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0229 0.0952 0.0952
Echinococcus multilocularis Tolloid protein 1 0.0045 0.0041 0.0041
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0041 0.0019 0.0019
Trichomonas vaginalis calmodulin, putative 0.0086 0.0241 0.0692
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0536 0.2474 0.2474
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.074 0.3491 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.0577 0.0577
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2877 0.8241
Echinococcus multilocularis hypothetical protein 0.0536 0.2474 0.2474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0153 0.0577 0.1652
Plasmodium vivax vivapain-2 0.0571 0.2649 1
Schistosoma mansoni neuronal calcium sensor 0.0086 0.0241 0.0241
Schistosoma mansoni calmodulin 0.0086 0.0241 0.0241
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0536 0.2474 0.7088
Brugia malayi EF hand family protein 0.0086 0.0241 0.0241
Echinococcus multilocularis EF hand domain containing family member A2 0.0087 0.0249 0.0249
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0153 0.0577 0.2177
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.005 0.005
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0153 0.0577 0.1652
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.008 0.0215 0.0617
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0377 0.1689 0.1689
Echinococcus granulosus calpain A 0.1521 0.7364 0.7364
Trypanosoma cruzi Aph-1 protein, putative 0.0096 0.0292 0.0292
Entamoeba histolytica cysteine proteinase, putative 0.0571 0.2649 1
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.008 0.0215 0.0617
Trichomonas vaginalis calcineurin B subunit, putative 0.0086 0.0241 0.0692
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0397 0.1788 0.4185
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0229 0.0952 0.2726
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0571 0.2649 0.2649
Plasmodium vivax vivapain-1 0.0322 0.1417 0.5348
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2052 1 1
Trypanosoma brucei antigen, putative 0.0536 0.2474 0.7088
Schistosoma mansoni mitochondrial solute carrier 0.0086 0.0241 0.0241
Onchocerca volvulus 0.0041 0.0021 0.0049
Brugia malayi calpain 7 0.0536 0.2474 0.2474
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0215 0.0215
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0021 0.0021
Plasmodium vivax vivapain-3 0.0322 0.1417 0.5348
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.074 0.3491 0.3491
Schistosoma mansoni gamma-secretase subunit aph-1 0.0246 0.1037 0.1037
Entamoeba histolytica cysteine proteinase, putative 0.0322 0.1417 0.4937
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0021 0.0021
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0153 0.0577 0.0577
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0045 0.004 0.004
Echinococcus granulosus calumenin 0.0087 0.0249 0.0249
Trichomonas vaginalis calcium binding protein, putative 0.0086 0.0241 0.0692

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 40 mg kg-1 Anti-tetrabenazine (TBZ) activity, ability to prevent TBZ-induced ptosis in mice ChEMBL. 6471069
ED50 (functional) > 40 mg kg-1 Anti-tetrabenazine (TBZ) activity, ability to prevent TBZ-induced ptosis in mice ChEMBL. 6471069
IC50 (functional) = 0.18 uM In vitro inhibition of norepinephrine uptake in rat brain synaptosomes using [3H]-NE ChEMBL. 6471069
IC50 (functional) = 0.21 uM In vitro inhibition of 5-HT uptake in rat brain synaptosomes using [3H]- 5-hydroxytryptamine ChEMBL. 6471069

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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