Detailed information for compound 1705866

Basic information

Technical information
  • TDR Targets ID: 1705866
  • Name: 4-methyl-2,6-di(morpholin-4-yl)pyridine-3-car bonitrile
  • MW: 288.345 | Formula: C15H20N4O2
  • H donors: 0 H acceptors: 2 LogP: 1.1 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(C)cc(nc1N1CCOCC1)N1CCOCC1
  • InChi: 1S/C15H20N4O2/c1-12-10-14(18-2-6-20-7-3-18)17-15(13(12)11-16)19-4-8-21-9-5-19/h10H,2-9H2,1H3
  • InChiKey: ZKMFQONOZHCDSN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-methyl-2,6-dimorpholino-pyridine-3-carbonitrile
  • 4-methyl-2,6-dimorpholino-3-pyridinecarbonitrile
  • 4-methyl-2,6-dimorpholino-nicotinonitrile
  • 51560-95-3
  • 3-Pyridinecarbonitrile, 4-methyl-2,6-di-4-morpholinyl-
  • NSC341981

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) calpain family protein 1 0.2954 0.7418 0.7418
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.1479
Toxoplasma gondii EFHC1, putative 0.0188 0.0181 0.0586
Giardia lamblia Hypothetical protein 0.0189 0.0185 0.0597
Trypanosoma brucei calpain-like protein, putative 0.1085 0.2529 0.8176
Loa Loa (eye worm) EF hand family protein 0.0188 0.0181 0.0181
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.1479
Loa Loa (eye worm) calpain 5 0.0792 0.1762 0.1762
Trypanosoma cruzi centrin-3 0.0269 0.0394 0.0394
Brugia malayi programmed cell death protein 6 0.0188 0.0181 0.0181
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.0458
Trypanosoma brucei calpain-like protein, putative 0.1085 0.2529 0.8176
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0188 0.0181 0.0181
Loa Loa (eye worm) calpain 0.1085 0.2529 0.2529
Leishmania major calpain protease-like protein 0.0293 0.0458 0.1479
Leishmania major centrin, putative 0.0188 0.0181 0.0586
Toxoplasma gondii calmodulin CAM1 0.0189 0.0185 0.0597
Trypanosoma brucei cysteine peptidase, putative 0.0293 0.0458 0.1479
Schistosoma mansoni calpain-7 (C02 family) 0.1085 0.2529 0.2529
Loa Loa (eye worm) hypothetical protein 0.0293 0.0458 0.0458
Schistosoma mansoni neuronal calcium sensor 0.0188 0.0181 0.0181
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.1085 0.2529 0.8176
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0293 0.0458 0.1479
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1301 0.3093 1
Plasmodium falciparum calpain 0.0293 0.0458 1
Trichomonas vaginalis calcium binding protein, putative 0.0269 0.0394 0.1275
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.1479
Trichomonas vaginalis calcium binding protein, putative 0.0188 0.0181 0.0586
Echinococcus multilocularis EF hand domain containing family member A2 0.0189 0.0185 0.0185
Brugia malayi calpain D 0.0293 0.0458 0.0458
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0293 0.0458 0.0458
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1085 0.2529 0.2529
Leishmania major calmodulin-like protein 0.0188 0.0181 0.0586
Trypanosoma brucei hypothetical protein 0.0293 0.0458 0.1479
Schistosoma mansoni calmodulin related calcium binding protein 0.0188 0.0181 0.0181
Leishmania major hypothetical protein, conserved 0.0293 0.0458 0.1479
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0293 0.0458 0.1479
Trypanosoma brucei calpain-like protein, putative 0.1085 0.2529 0.8176
Schistosoma mansoni calpain-2 (C02 family) 0.0293 0.0458 0.0458
Trypanosoma brucei kinesin, putative 0.0792 0.1762 0.5697
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0293 0.0458 0.1479
Brugia malayi calpain 7 0.1085 0.2529 0.2529
Trichomonas vaginalis calcium binding protein, putative 0.0188 0.0181 0.0586
Trypanosoma cruzi calmodulin, putative 0.0188 0.0181 0.0181
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0293 0.0458 0.1479
Trypanosoma cruzi calmodulin, putative 0.0188 0.0181 0.0181
Schistosoma mansoni hypothetical protein 0.0188 0.0181 0.0181
Trichomonas vaginalis calmodulin, putative 0.0188 0.0181 0.0586
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0188 0.0181 0.0181
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.1479
Loa Loa (eye worm) calpain D 0.0293 0.0458 0.0458
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.0458
Trypanosoma cruzi caltractin, putative 0.0188 0.0181 0.0181
Echinococcus multilocularis calmodulin 0.0188 0.0181 0.0181
Echinococcus multilocularis cathepsin b 0.3941 1 1
Echinococcus granulosus calumenin 0.0189 0.0185 0.0185
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0188 0.0181 0.0181
Schistosoma mansoni rab 0.0188 0.0181 0.0181
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0188 0.0181 0.0181
Toxoplasma gondii calcium-dependent protein kinase 0.0189 0.0185 0.0597
Schistosoma mansoni Mername-AA248 (C02 family) 0.1085 0.2529 0.2529
Trypanosoma brucei centrin, putative 0.0188 0.0181 0.0586
Leishmania major hypothetical protein, conserved 0.0189 0.0185 0.0597
Echinococcus multilocularis neuronal calcium sensor 0.0188 0.0181 0.0181
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0188 0.0181 0.0181
Echinococcus multilocularis calpain 7 (C02 family) 0.1085 0.2529 0.2529
Leishmania major calmodulin-like protein 0.0188 0.0181 0.0586
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0188 0.0181 0.1029
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3941 1 1
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0293 0.0458 0.1479
Loa Loa (eye worm) calpain family protein 1 0.2162 0.5347 0.5347
Onchocerca volvulus 0.0189 0.0185 0.0403
Loa Loa (eye worm) hypothetical protein 0.2162 0.5347 0.5347
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1085 0.2529 0.2529
Schistosoma mansoni calpain C (C02 family) 0.1085 0.2529 0.2529
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0293 0.0458 0.0458
Echinococcus granulosus calcium uptake protein 1 0.0189 0.0185 0.0185
Trichomonas vaginalis calmodulin, putative 0.0188 0.0181 0.0586
Echinococcus granulosus calpain 5 0.1085 0.2529 0.2529
Trypanosoma brucei Calpain-like protein 1.1 0.0293 0.0458 0.1479
Echinococcus granulosus calpain 7 C02 family 0.1085 0.2529 0.2529
Schistosoma mansoni ef hand domain family member A2 0.0188 0.0181 0.0181
Schistosoma mansoni reticulocalbin 0.0189 0.0185 0.0185
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0188 0.0181 0.0586
Trichomonas vaginalis hypothetical protein 0.0293 0.0458 0.1479
Trichomonas vaginalis centrin, putative 0.0188 0.0181 0.0586
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.0458
Trypanosoma brucei calmodulin, putative 0.0188 0.0181 0.0586
Brugia malayi calpain family protein 1 0.2954 0.7418 0.7418
Brugia malayi calpain family protein 1 0.2954 0.7418 0.7418
Echinococcus multilocularis calcium uptake protein 1 0.0189 0.0185 0.0185
Trichomonas vaginalis calmodulin, putative 0.0188 0.0181 0.0586
Entamoeba histolytica calpain large subunit domain III containing protein 0.0792 0.1762 1
Trichomonas vaginalis calcineurin B subunit, putative 0.0188 0.0181 0.0586
Leishmania major calmodulin, putative 0.0188 0.0181 0.0586
Trypanosoma brucei centrin-3 0.0269 0.0394 0.1275
Echinococcus granulosus EF hand domain containing family member A2 0.0188 0.0181 0.0181
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1085 0.2529 0.2529
Trichomonas vaginalis calpain, putative 0.0293 0.0458 0.1479
Trypanosoma brucei calpain, putative 0.0293 0.0458 0.1479
Leishmania major hypothetical protein, unknown function 0.0293 0.0458 0.1479
Schistosoma mansoni centrin-related 0.0188 0.0181 0.0181
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1085 0.2529 0.2529
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.1479
Trypanosoma cruzi conserved protein 0.0293 0.0458 0.0458
Echinococcus multilocularis programmed cell death protein 0.0269 0.0394 0.0394
Plasmodium vivax hypothetical protein, conserved 0.0189 0.0185 0.073
Echinococcus multilocularis calpain 5 0.1085 0.2529 0.2529
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0293 0.0458 0.0458
Loa Loa (eye worm) calmodulin-like protein 0.0188 0.0181 0.0181
Echinococcus multilocularis programmed cell death protein 0.0269 0.0394 0.0394
Entamoeba histolytica calmodulin, putative 0.0188 0.0181 0.1029
Loa Loa (eye worm) hypothetical protein 0.1869 0.458 0.458
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3941 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0188 0.0181 0.0586
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.1479
Giardia lamblia Cathepsin B precursor 0.1301 0.3093 1
Onchocerca volvulus 0.0188 0.0181 0.0396
Schistosoma mansoni calpain-7 (C02 family) 0.1085 0.2529 0.2529
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.1479
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.1479
Trichomonas vaginalis calcium binding proteins, putative 0.0188 0.0181 0.0586
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0293 0.0458 0.0458
Toxoplasma gondii cathepsin B 0.1301 0.3093 1
Trypanosoma brucei calpain-like protein, putative 0.1085 0.2529 0.8176
Trypanosoma brucei mitochondrial calcium uptake 1 0.0188 0.0181 0.0586
Loa Loa (eye worm) hypothetical protein 0.0188 0.0181 0.0181
Schistosoma mansoni centrin 0.0188 0.0181 0.0181
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.3142 0.7908 0.7908
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.1479
Leishmania major kinesin, putative 0.0792 0.1762 0.5697
Echinococcus granulosus calbindin 32 0.0189 0.0185 0.0185
Entamoeba histolytica grainin, putative 0.0189 0.0185 0.1048
Toxoplasma gondii troponin c, isotype gamma, putative 0.0188 0.0181 0.0586
Toxoplasma gondii centrin 0.0188 0.0181 0.0586
Entamoeba histolytica calpain family cysteine protease, putative 0.0293 0.0458 0.2597
Echinococcus multilocularis calpain 0.1085 0.2529 0.2529
Trypanosoma cruzi centrin, putative 0.0269 0.0394 0.0394
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.1479
Trichomonas vaginalis calpain, putative 0.0293 0.0458 0.1479
Plasmodium vivax calpain, putative 0.1085 0.2529 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3142 0.7908 0.7908
Echinococcus multilocularis calpain family protein 1, d 0.2162 0.5347 0.5347
Schistosoma mansoni mitochondrial solute carrier 0.0188 0.0181 0.0181
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.1479
Trichomonas vaginalis conserved hypothetical protein 0.0293 0.0458 0.1479
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0188 0.0181 0.0181
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.1479
Trypanosoma brucei centrin, putative 0.0188 0.0181 0.0586
Schistosoma mansoni neuronal calcium sensor 0.0188 0.0181 0.0181
Leishmania major calcineurin B subunit, putative 0.0188 0.0181 0.0586
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.0458
Entamoeba histolytica grainin 2 0.0269 0.0394 0.2238
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0293 0.0458 0.0458
Trichomonas vaginalis centrin, putative 0.0188 0.0181 0.0586
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0293 0.0458 0.1479
Trypanosoma brucei Calpain-like protein CALP1.3 0.0293 0.0458 0.1479
Echinococcus multilocularis calumenin 0.0189 0.0185 0.0185
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0293 0.0458 0.0458
Brugia malayi calcium-binding protein 0.0188 0.0181 0.0181
Trichomonas vaginalis calmodulin, putative 0.0189 0.0185 0.0597
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.1479
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.1479
Trypanosoma cruzi centrin, putative 0.0269 0.0394 0.0394
Leishmania major phospholipase c-like protein 0.0188 0.0181 0.0586
Loa Loa (eye worm) hypothetical protein 0.3941 1 1
Schistosoma mansoni reticulocalbin 0.0188 0.0181 0.0181
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.1479
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1085 0.2529 0.2529
Toxoplasma gondii centrin, putative 0.0188 0.0181 0.0586
Schistosoma mansoni neuronal calcium sensor 0.0188 0.0181 0.0181
Toxoplasma gondii EF hand domain-containing protein 0.0188 0.0181 0.0586
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1301 0.3093 0.3093
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1085 0.2529 0.2529
Brugia malayi calpain 5 0.0293 0.0458 0.0458
Trypanosoma brucei calmodulin, putative 0.0189 0.0185 0.0597
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.1085 0.2529 0.8176
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0188 0.0181 0.1029
Echinococcus multilocularis neurocalcin 0.0188 0.0181 0.0181
Trypanosoma brucei cysteine peptidase C (CPC) 0.1301 0.3093 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.1479
Trypanosoma cruzi kinesin, putative 0.0792 0.1762 0.1762
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2954 0.7418 0.7418
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0293 0.0458 0.1479
Trichomonas vaginalis calmodulin, putative 0.0269 0.0394 0.1275
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0293 0.0458 0.0458
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.1479
Trypanosoma brucei I/6 autoantigen 0.0188 0.0181 0.0586
Trichomonas vaginalis calpain, putative 0.0293 0.0458 0.1479
Giardia lamblia Cathepsin B precursor 0.1301 0.3093 1
Entamoeba histolytica calcium-binding protein, putative 0.0188 0.0181 0.1029
Schistosoma mansoni hypothetical protein 0.0188 0.0181 0.0181
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3941 1 1
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0293 0.0458 0.1479
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.3142 0.7908 0.7908
Schistosoma mansoni calmodulin 0.0188 0.0181 0.0181
Trypanosoma brucei calpain, putative 0.0293 0.0458 0.1479
Trypanosoma brucei antigen, putative 0.1085 0.2529 0.8176
Brugia malayi EF hand family protein 0.0189 0.0185 0.0185
Trypanosoma brucei Component of motile flagella 41 0.0188 0.0181 0.0586
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.1085 0.2529 0.8176
Trypanosoma brucei Calpain-like protein 1.2 0.0293 0.0458 0.1479
Echinococcus granulosus neurocalcin 0.0188 0.0181 0.0181
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.0458
Plasmodium falciparum centrin-1 0.0188 0.0181 0.3962
Echinococcus granulosus neuronal calcium sensor 0.0188 0.0181 0.0181
Plasmodium vivax centrin-1, putative 0.0188 0.0181 0.0717
Echinococcus granulosus calpain A 0.3143 0.7912 0.7912
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1085 0.2529 0.2529
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.0458
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.1479
Trichomonas vaginalis calmodulin, putative 0.0188 0.0181 0.0586
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0188 0.0181 0.0586
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0293 0.0458 0.0458
Echinococcus multilocularis cathepsin b 0.3941 1 1
Echinococcus multilocularis hypothetical protein 0.1085 0.2529 0.2529
Echinococcus granulosus EF hand domain containing family member A2 0.0189 0.0185 0.0185
Trypanosoma brucei protein I/6 0.0188 0.0181 0.0586
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1085 0.2529 0.2529
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.1479
Loa Loa (eye worm) cathepsin B 0.1301 0.3093 0.3093
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1085 0.2529 0.2529
Echinococcus granulosus programmed cell death protein 0.0269 0.0394 0.0394
Trichomonas vaginalis calmodulin, putative 0.0188 0.0181 0.0586
Trichomonas vaginalis calmodulin-2, putative 0.0188 0.0181 0.0586
Echinococcus granulosus calpain 0.1085 0.2529 0.2529
Leishmania major calmodulin, putative 0.0188 0.0181 0.0586
Echinococcus multilocularis calmodulin 0.0188 0.0181 0.0181
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0293 0.0458 0.1479
Loa Loa (eye worm) hypothetical protein 0.2954 0.7418 0.7418
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0293 0.0458 0.1479
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.3941 1 1
Schistosoma mansoni hypothetical protein 0.0293 0.0458 0.0458
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0188 0.0181 0.0181
Trypanosoma cruzi calpain cysteine peptidase, putative 0.1085 0.2529 0.2529
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0188 0.0181 0.0586
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.0458
Onchocerca volvulus 0.1869 0.458 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1085 0.2529 0.8176
Brugia malayi Calmodulin-like protein 0.0188 0.0181 0.0181
Trichomonas vaginalis calcium binding protein, putative 0.0188 0.0181 0.0586
Loa Loa (eye worm) hypothetical protein 0.2661 0.6651 0.6651
Echinococcus granulosus cathepsin b 0.3941 1 1
Trichomonas vaginalis calmodulin, putative 0.0188 0.0181 0.0586
Entamoeba histolytica calmodulin, putative 0.0188 0.0181 0.1029
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1301 0.3093 1
Schistosoma mansoni calmodulin 0.0188 0.0181 0.0181
Trypanosoma cruzi I/6 autoantigen, putative 0.0188 0.0181 0.0181
Trypanosoma cruzi I/6 autoantigen, putative 0.0188 0.0181 0.0181
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.3941 1 1
Loa Loa (eye worm) hypothetical protein 0.0188 0.0181 0.0181
Echinococcus granulosus calpain A 0.1085 0.2529 0.2529
Echinococcus multilocularis calpain A 0.3143 0.7912 0.7912
Echinococcus multilocularis centrin 2 0.0188 0.0181 0.0181
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1301 0.3093 0.3093
Trypanosoma cruzi calmodulin, putative 0.0188 0.0181 0.0181
Schistosoma mansoni calpain (C02 family) 0.1085 0.2529 0.2529
Trypanosoma brucei caltractin, putative 0.0269 0.0394 0.1275
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1085 0.2529 0.8176
Trichomonas vaginalis calmodulin, putative 0.0188 0.0181 0.0586
Leishmania major i/6 autoantigen-like protein 0.0188 0.0181 0.0586
Leishmania major programmed cell death 6 protein-like protein 0.0188 0.0181 0.0586
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0188 0.0181 0.0181
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0293 0.0458 0.0458
Entamoeba histolytica protein kinase, putative 0.0792 0.1762 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0188 0.0181 0.0717
Echinococcus granulosus cathepsin b 0.3941 1 1
Echinococcus granulosus calmodulin 0.0188 0.0181 0.0181
Echinococcus multilocularis calbindin 32 0.0189 0.0185 0.0185
Entamoeba histolytica calcium binding family protein 0.0188 0.0181 0.1029
Leishmania major protein kinase, putative 0.0188 0.0181 0.0586
Toxoplasma gondii hypothetical protein 0.0293 0.0458 0.1479
Echinococcus granulosus centrin 2 0.0188 0.0181 0.0181
Schistosoma mansoni neuronal calcium sensor 0.0188 0.0181 0.0181
Leishmania major calpain family cysteine protease-like protein 0.0293 0.0458 0.1479
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0188 0.0181 0.0181
Entamoeba histolytica hypothetical protein, conserved 0.0189 0.0185 0.1048
Trichomonas vaginalis calcineurin B subunit, putative 0.0189 0.0185 0.0597
Trichomonas vaginalis myosin light chain 1, putative 0.0188 0.0181 0.0586
Echinococcus granulosus EF HAND 1 calcium binding site 0.0188 0.0181 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0188 0.0181 0.0586
Echinococcus multilocularis EF hand domain containing family member A2 0.0188 0.0181 0.0181
Brugia malayi EF hand family protein 0.0188 0.0181 0.0181
Leishmania major centrin, putative,caltractin, putative 0.0188 0.0181 0.0586
Giardia lamblia Cathepsin B precursor 0.1301 0.3093 1
Leishmania major centrin, putative 0.0188 0.0181 0.0586
Onchocerca volvulus 0.0188 0.0181 0.0396
Brugia malayi calpain 5 0.0792 0.1762 0.1762
Trypanosoma cruzi kinesin, putative 0.0792 0.1762 0.1762
Leishmania major hypothetical protein, conserved 0.0188 0.0181 0.0586
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0189 0.0185 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0188 0.0181 0.0586
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0189 0.0185 0.0185
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3142 0.7908 0.7908
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0188 0.0181 0.0586
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0293 0.0458 0.0458
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0293 0.0458 0.0458
Loa Loa (eye worm) programmed cell death protein 6 0.0189 0.0185 0.0185
Trypanosoma brucei Calpain-like protein 2 0.0293 0.0458 0.1479

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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