Detailed information for compound 1799157

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 329.437 | Formula: C19H27N3O2
  • H donors: 0 H acceptors: 2 LogP: 2.94 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCn1c(=O)n(CCN2CCCCC2)c2c(c1=O)cccc2
  • InChi: 1S/C19H27N3O2/c1-2-3-13-22-18(23)16-9-5-6-10-17(16)21(19(22)24)15-14-20-11-7-4-8-12-20/h5-6,9-10H,2-4,7-8,11-15H2,1H3
  • InChiKey: LPBNYDBKCOQPLW-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni calpain (C02 family) 0.1399 0.3196 0.3198
Trypanosoma brucei mitochondrial calcium uptake 1 0.0247 0.0214 0.0272
Trypanosoma brucei Calpain-like protein 1.1 0.0391 0.0587 0.0744
Brugia malayi Endoplasmin precursor 0.0178 0.0037 0.0039
Echinococcus multilocularis calpain family protein 1, d 0.2771 0.6746 0.6746
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0744
Trypanosoma cruzi heat shock protein 85, putative 0.0178 0.0037 0.0039
Trichomonas vaginalis calmodulin, putative 0.0247 0.0214 0.0734
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1399 0.3196 0.331
Mycobacterium leprae Probable two component sensor kinase MprB 0.0178 0.0037 0.5
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0391 0.0587 0.2011
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1399 0.3196 0.331
Toxoplasma gondii heat shock protein 90, putative 0.0178 0.0037 0.0127
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.4026 0.9993 0.9993
Loa Loa (eye worm) heat shock protein 90 0.0178 0.0037 0.0039
Leishmania major heat shock protein 83-1 0.0178 0.0037 0.0048
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.1122 0.2478 0.8429
Schistosoma mansoni calmodulin 0.0247 0.0214 0.0214
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0247 0.0214 0.0214
Brugia malayi calcium-binding protein 0.0247 0.0214 0.0222
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0391 0.0587 0.0607
Schistosoma mansoni calpain-2 (C02 family) 0.0391 0.0587 0.0587
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1399 0.3196 0.331
Onchocerca volvulus 0.0247 0.0214 0.0373
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.3895 0.9656 0.9662
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0178 0.0037 0.0037
Leishmania major i/6 autoantigen-like protein 0.0247 0.0214 0.0272
Trichomonas vaginalis centrin, putative 0.0247 0.0214 0.0734
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0744
Echinococcus granulosus calpain 7 C02 family 0.1399 0.3196 0.3196
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0247 0.0214 0.0222
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0744
Echinococcus granulosus calpain 0.1399 0.3196 0.3196
Echinococcus multilocularis calbindin 32 0.0249 0.0221 0.0221
Toxoplasma gondii calcium-dependent protein kinase 0.0249 0.0221 0.0751
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0391 0.0587 0.0607
Onchocerca volvulus 0.0247 0.0214 0.0373
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3895 0.9656 0.9662
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0744
Echinococcus granulosus cathepsin b 0.3895 0.9656 0.9656
Trichomonas vaginalis endoplasmin, putative 0.0178 0.0037 0.0128
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0178 0.0037 0.5
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0178 0.0037 0.5
Loa Loa (eye worm) calmodulin-like protein 0.0247 0.0214 0.0222
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0247 0.0214 0.098
Schistosoma mansoni pyruvate dehydrogenase 0.303 0.7417 0.7422
Trichomonas vaginalis hypothetical protein 0.0391 0.0587 0.2011
Echinococcus granulosus calmodulin 0.0247 0.0214 0.0214
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0391 0.0587 0.0607
Trypanosoma brucei Heat shock protein 83, putative 0.0178 0.0037 0.0048
Loa Loa (eye worm) calpain D 0.0391 0.0587 0.0607
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0391 0.0587 0.2011
Loa Loa (eye worm) calpain family protein 1 0.3779 0.9355 0.9688
Trypanosoma brucei Calpain-like protein 1.2 0.0391 0.0587 0.0744
Trypanosoma brucei cysteine peptidase C (CPC) 0.1291 0.2917 0.3703
Schistosoma mansoni centrin-related 0.0247 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0391 0.0587 0.0607
Trypanosoma brucei heat shock protein, putative 0.0178 0.0037 0.0048
Loa Loa (eye worm) calpain family protein 1 0.2771 0.6746 0.6986
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0178 0.0037 0.5
Trypanosoma cruzi Heat shock protein 83, putative 0.0178 0.0037 0.0039
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0178 0.0037 0.0127
Echinococcus granulosus heat shock protein 0.0178 0.0037 0.0037
Echinococcus granulosus neuronal calcium sensor 0.0247 0.0214 0.0214
Echinococcus multilocularis EF hand domain containing family member A2 0.0247 0.0214 0.0214
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1399 0.3196 0.331
Trichomonas vaginalis DNA topoisomerase II, putative 0.0178 0.0037 0.0128
Mycobacterium leprae Probable two-component sensor kinase 0.0178 0.0037 0.5
Plasmodium vivax endoplasmin, putative 0.0178 0.0037 0.0117
Entamoeba histolytica grainin 2 0.0332 0.0435 0.1991
Giardia lamblia Cathepsin B precursor 0.1291 0.2917 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1399 0.3196 0.4056
Leishmania major heat shock protein 83-1 0.0178 0.0037 0.0048
Trypanosoma brucei heat shock protein, putative 0.0178 0.0037 0.0048
Plasmodium falciparum heat shock protein 90 0.0178 0.0037 0.0639
Loa Loa (eye worm) programmed cell death protein 6 0.0249 0.0221 0.0229
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.3209 0.7879 0.7879
Schistosoma mansoni rab 0.0247 0.0214 0.0214
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0247 0.0214 0.098
Chlamydia trachomatis DNA gyrase subunit B 0.0178 0.0037 0.5
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1399 0.3196 0.331
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0744
Loa Loa (eye worm) hypothetical protein 0.3895 0.9656 1
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0247 0.0214 0.0272
Trypanosoma brucei DNA topoisomerase ii 0.0178 0.0037 0.0048
Schistosoma mansoni endoplasmin 0.0178 0.0037 0.0037
Plasmodium falciparum endoplasmin, putative 0.0178 0.0037 0.0639
Trichomonas vaginalis conserved hypothetical protein 0.0247 0.0214 0.0734
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0391 0.0587 0.2011
Toxoplasma gondii hypothetical protein 0.0391 0.0587 0.1995
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0391 0.0587 0.0744
Trypanosoma cruzi centrin, putative 0.0332 0.0435 0.0451
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0247 0.0214 0.0734
Brugia malayi calpain 5 0.0391 0.0587 0.0607
Trypanosoma brucei caltractin, putative 0.0332 0.0435 0.0552
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0391 0.0587 0.0607
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0178 0.0037 0.0127
Entamoeba histolytica protein kinase, putative 0.1008 0.2185 1
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0178 0.0037 0.0128
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0178 0.0037 0.5
Leishmania major centrin, putative 0.0247 0.0214 0.0272
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0178 0.0037 0.5
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0391 0.0587 0.0607
Trypanosoma cruzi conserved protein 0.0391 0.0587 0.0607
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0391 0.0587 0.0744
Leishmania major calmodulin-like protein 0.0247 0.0214 0.0272
Loa Loa (eye worm) hypothetical protein 0.0247 0.0214 0.0222
Schistosoma mansoni hypothetical protein 0.0247 0.0214 0.0214
Echinococcus granulosus EF hand domain containing family member A2 0.0247 0.0214 0.0214
Trypanosoma cruzi calmodulin, putative 0.0247 0.0214 0.0222
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0391 0.0587 0.0607
Trichomonas vaginalis heat shock protein, putative 0.0178 0.0037 0.0128
Plasmodium vivax heat shock protein 86, putative 0.0178 0.0037 0.0117
Entamoeba histolytica calpain large subunit domain III containing protein 0.1008 0.2185 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0178 0.0037 0.0128
Trichomonas vaginalis sensor histidine kinase, putative 0.0178 0.0037 0.0128
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0178 0.0037 0.5
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0247 0.0214 0.067
Chlamydia trachomatis DNA gyrase subunit B 0.0178 0.0037 0.5
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0744
Mycobacterium tuberculosis Possible two component sensor kinase 0.0178 0.0037 0.5
Trichomonas vaginalis calpain, putative 0.0391 0.0587 0.2011
Leishmania major hypothetical protein, conserved 0.0391 0.0587 0.0744
Trypanosoma cruzi centrin-3 0.0332 0.0435 0.0451
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0744
Leishmania major heat shock protein 83-1 0.0178 0.0037 0.0048
Trypanosoma brucei hypothetical protein, conserved 0.0247 0.0214 0.0272
Echinococcus granulosus cathepsin b 0.3895 0.9656 0.9656
Leishmania major heat shock protein 83-1 0.0178 0.0037 0.0048
Toxoplasma gondii calmodulin CAM1 0.0249 0.0221 0.0751
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0178 0.0037 0.5
Trypanosoma cruzi I/6 autoantigen, putative 0.0247 0.0214 0.0222
Echinococcus granulosus calcium uptake protein 1 0.0249 0.0221 0.0221
Schistosoma mansoni calmodulin related calcium binding protein 0.0247 0.0214 0.0214
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.1399 0.3196 0.4056
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1291 0.2917 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0178 0.0037 0.0065
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0178 0.0037 0.0037
Plasmodium falciparum DNA gyrase subunit B 0.0178 0.0037 0.0639
Trichomonas vaginalis centrin, putative 0.0247 0.0214 0.0734
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0247 0.0214 0.0214
Schistosoma mansoni pyruvate dehydrogenase 0.303 0.7417 0.7422
Leishmania major DNA topoisomerase ii 0.0178 0.0037 0.0048
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0249 0.0221 0.0221
Leishmania major heat shock protein 83-1 0.0178 0.0037 0.0048
Echinococcus multilocularis neurocalcin 0.0247 0.0214 0.0214
Echinococcus granulosus neurocalcin 0.0247 0.0214 0.0214
Brugia malayi EF hand family protein 0.0247 0.0214 0.0222
Trypanosoma brucei heat shock protein 90, putative 0.0178 0.0037 0.0048
Trypanosoma cruzi calmodulin, putative 0.0247 0.0214 0.0222
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0247 0.0214 0.0214
Trypanosoma cruzi centrin, putative 0.0332 0.0435 0.0451
Entamoeba histolytica heat shock protein 90, putative 0.0178 0.0037 0.0172
Schistosoma mansoni heat shock protein 0.0178 0.0037 0.0037
Echinococcus multilocularis programmed cell death protein 0.0332 0.0435 0.0435
Echinococcus granulosus centrin 2 0.0247 0.0214 0.0214
Entamoeba histolytica calmodulin, putative 0.0247 0.0214 0.098
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0744
Trypanosoma brucei heat shock protein, putative 0.0178 0.0037 0.0048
Schistosoma mansoni neuronal calcium sensor 0.0247 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0178 0.0037 0.0039
Toxoplasma gondii DNA topoisomerase 2, putative 0.0178 0.0037 0.0127
Leishmania major hypothetical protein, conserved 0.0178 0.0037 0.0048
Schistosoma mansoni heat shock protein 0.0178 0.0037 0.0037
Trypanosoma brucei heat shock protein, putative 0.0178 0.0037 0.0048
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0247 0.0214 0.0222
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.1122 0.2478 0.3146
Trichomonas vaginalis calmodulin, putative 0.0332 0.0435 0.1491
Toxoplasma gondii EFHC1, putative 0.0247 0.0214 0.0728
Trichomonas vaginalis calmodulin, putative 0.0247 0.0214 0.0734
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0247 0.0214 0.0222
Leishmania major heat shock protein 83-1 0.0178 0.0037 0.0048
Echinococcus multilocularis calpain A 0.4029 1 1
Schistosoma mansoni hypothetical protein 0.0247 0.0214 0.0214
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1291 0.2917 0.3703
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0391 0.0587 0.0607
Trypanosoma brucei calmodulin, putative 0.0247 0.0214 0.0272
Brugia malayi Calmodulin-like protein 0.0247 0.0214 0.0222
Trypanosoma brucei centrin, putative 0.0247 0.0214 0.0272
Leishmania major hypothetical protein, conserved 0.0247 0.0214 0.0272
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1399 0.3196 0.331
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0744
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0178 0.0037 0.0039
Plasmodium vivax DNA topoisomerase II, putative 0.0178 0.0037 0.0117
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.1399 0.3196 0.4056
Loa Loa (eye worm) hypothetical protein 0.2771 0.6746 0.6986
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0178 0.0037 0.5
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0247 0.0214 0.0272
Trichomonas vaginalis calcium binding protein, putative 0.0247 0.0214 0.0734
Schistosoma mansoni calpain C (C02 family) 0.1399 0.3196 0.3198
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0178 0.0037 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3895 0.9656 0.9662
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0178 0.0037 0.0048
Trichomonas vaginalis calcineurin B subunit, putative 0.0249 0.0221 0.0757
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3895 0.9656 0.9662
Echinococcus multilocularis calmodulin 0.0247 0.0214 0.0214
Brugia malayi programmed cell death protein 6 0.0247 0.0214 0.0222
Trypanosoma cruzi calmodulin, putative 0.0247 0.0214 0.0222
Toxoplasma gondii centrin, putative 0.0247 0.0214 0.0728
Mycobacterium tuberculosis Conserved protein 0.0178 0.0037 0.5
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.3209 0.7879 0.7879
Leishmania major heat shock protein 83-1 0.0178 0.0037 0.0048
Schistosoma mansoni neuronal calcium sensor 0.0247 0.0214 0.0214
Trichomonas vaginalis calmodulin, putative 0.0249 0.0221 0.0757
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0178 0.0037 0.0039
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.3895 0.9656 1
Loa Loa (eye worm) hypothetical protein 0.3388 0.8344 0.8641
Plasmodium falciparum centrin-1 0.0247 0.0214 0.3649
Trichomonas vaginalis myosin light chain 1, putative 0.0247 0.0214 0.0734
Trypanosoma brucei calpain-like protein, putative 0.1399 0.3196 0.4056
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.3209 0.7879 0.7879
Leishmania major calcineurin B subunit, putative 0.0247 0.0214 0.0272
Plasmodium falciparum calpain 0.0391 0.0587 1
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.1399 0.3196 0.4056
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0178 0.0037 0.5
Leishmania major calmodulin, putative 0.0247 0.0214 0.0272
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0607
Echinococcus multilocularis cathepsin b 0.3895 0.9656 0.9656
Schistosoma mansoni centrin 0.0247 0.0214 0.0214
Schistosoma mansoni hypothetical protein 0.0391 0.0587 0.0587
Leishmania major heat shock protein 83-1 0.0178 0.0037 0.0048
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.3779 0.9355 0.9361
Echinococcus multilocularis heat shock protein 0.0178 0.0037 0.0037
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0247 0.0214 0.0222
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0178 0.0037 0.0048
Trichomonas vaginalis calcineurin B subunit, putative 0.0247 0.0214 0.0734
Loa Loa (eye worm) calpain 5 0.1008 0.2185 0.2263
Onchocerca volvulus 0.238 0.5735 1
Toxoplasma gondii heat shock protein HSP90 0.0178 0.0037 0.0127
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0178 0.0037 0.0128
Leishmania major calmodulin, putative 0.0247 0.0214 0.0272
Trypanosoma cruzi calpain cysteine peptidase, putative 0.1399 0.3196 0.331
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.3209 0.7879 0.816
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0178 0.0037 0.5
Echinococcus multilocularis calumenin 0.0249 0.0221 0.0221
Leishmania major developmentally regulated phosphoprotein-like protein 0.3209 0.7879 1
Leishmania major heat shock protein 83-1 0.0178 0.0037 0.0048
Trypanosoma brucei heat shock protein, putative 0.0178 0.0037 0.0048
Trypanosoma cruzi heat shock protein 85, putative 0.0178 0.0037 0.0039
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0391 0.0587 0.2011
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0178 0.0037 0.5
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.4026 0.9993 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0178 0.0037 0.0039
Trichomonas vaginalis calcium binding proteins, putative 0.0247 0.0214 0.0734
Toxoplasma gondii troponin c, isotype gamma, putative 0.0247 0.0214 0.0728
Trypanosoma brucei calpain-like protein, putative 0.1399 0.3196 0.4056
Entamoeba histolytica DNA topoisomerase II, putative 0.0178 0.0037 0.0172
Echinococcus multilocularis programmed cell death protein 0.0332 0.0435 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0247 0.0214 0.0734
Echinococcus multilocularis neuronal calcium sensor 0.0247 0.0214 0.0214
Toxoplasma gondii centrin 0.0247 0.0214 0.0728
Schistosoma mansoni neuronal calcium sensor 0.0247 0.0214 0.0214
Trypanosoma brucei calmodulin, putative 0.0249 0.0221 0.028
Trypanosoma brucei antigen, putative 0.1399 0.3196 0.4056
Trypanosoma brucei calpain, putative 0.0391 0.0587 0.0744
Trichomonas vaginalis calmodulin-2, putative 0.0247 0.0214 0.0734
Entamoeba histolytica calmodulin, putative 0.0247 0.0214 0.098
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0178 0.0037 0.5
Trichomonas vaginalis calmodulin, putative 0.0247 0.0214 0.0734
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0744
Schistosoma mansoni DNA topoisomerase II 0.0178 0.0037 0.0037
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.4026 0.9993 1
Trichomonas vaginalis calmodulin, putative 0.0247 0.0214 0.0734
Leishmania major heat shock protein 83-1 0.0178 0.0037 0.0048
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0178 0.0037 0.5
Leishmania major heat shock protein 83-1 0.0178 0.0037 0.0048
Trypanosoma cruzi caltractin, putative 0.0247 0.0214 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.0391 0.0587 0.2011
Mycobacterium ulcerans DNA gyrase subunit B 0.0178 0.0037 0.5
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0178 0.0037 0.5
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0178 0.0037 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1291 0.2917 0.2919
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0178 0.0037 0.5
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0247 0.0214 0.0214
Schistosoma mansoni neuronal calcium sensor 0.0247 0.0214 0.0214
Trypanosoma brucei Calpain-like protein CALP1.3 0.0391 0.0587 0.0744
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0247 0.0214 0.0734
Leishmania major protein kinase, putative 0.0247 0.0214 0.0272
Schistosoma mansoni calmodulin 0.0247 0.0214 0.0214
Entamoeba histolytica calcium-binding protein, putative 0.0247 0.0214 0.098
Trichomonas vaginalis calcium binding protein, putative 0.0247 0.0214 0.0734
Leishmania major kinesin, putative 0.1008 0.2185 0.2773
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0247 0.0214 0.0222
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1399 0.3196 0.4056
Trypanosoma brucei protein I/6 0.0247 0.0214 0.0272
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0178 0.0037 0.5
Leishmania major mitochondrial DNA topoisomerase II 0.0178 0.0037 0.0048
Trypanosoma brucei cysteine peptidase, putative 0.0391 0.0587 0.0744
Trypanosoma brucei heat shock protein, putative 0.0178 0.0037 0.0048
Toxoplasma gondii cathepsin B 0.1291 0.2917 0.9922
Trichomonas vaginalis receptor histidine kinase, putative 0.0178 0.0037 0.0128
Trypanosoma cruzi kinesin, putative 0.1008 0.2185 0.2263
Trypanosoma cruzi heat shock protein 90, putative 0.0178 0.0037 0.0039
Echinococcus multilocularis hypothetical protein 0.1399 0.3196 0.3196
Schistosoma mansoni reticulocalbin 0.0247 0.0214 0.0214
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0391 0.0587 0.0607
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0391 0.0587 0.0607
Loa Loa (eye worm) EF hand family protein 0.0247 0.0214 0.0222
Leishmania major calpain protease-like protein 0.0391 0.0587 0.0744
Echinococcus multilocularis calpain 7 (C02 family) 0.1399 0.3196 0.3196
Leishmania major centrin, putative,caltractin, putative 0.0247 0.0214 0.0272
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0607
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0178 0.0037 0.0065
Giardia lamblia Cathepsin B precursor 0.1291 0.2917 1
Trypanosoma brucei centrin-3 0.0332 0.0435 0.0552
Trypanosoma brucei Component of motile flagella 41 0.0247 0.0214 0.0272
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0607
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0178 0.0037 0.0639
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0391 0.0587 0.2011
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0178 0.0037 0.5
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0391 0.0587 0.0744
Loa Loa (eye worm) hypothetical protein 0.3209 0.7879 0.816
Brugia malayi calpain 5 0.1008 0.2185 0.2263
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1399 0.3196 0.331
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0178 0.0037 0.0039
Toxoplasma gondii EF hand domain-containing protein 0.0247 0.0214 0.0728
Trypanosoma brucei kinesin, putative 0.1008 0.2185 0.2773
Loa Loa (eye worm) calpain 0.1399 0.3196 0.331
Entamoeba histolytica calpain family cysteine protease, putative 0.0391 0.0587 0.2685
Entamoeba histolytica hypothetical protein, conserved 0.0249 0.0221 0.1011
Trypanosoma cruzi heat shock protein 85, putative 0.0178 0.0037 0.0039
Trichomonas vaginalis calmodulin, putative 0.0247 0.0214 0.0734
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0391 0.0587 0.0607
Leishmania major heat shock protein 83-1 0.0178 0.0037 0.0048
Trichomonas vaginalis calmodulin, putative 0.0247 0.0214 0.0734
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1399 0.3196 0.331
Echinococcus granulosus calpain 5 0.1399 0.3196 0.3196
Leishmania major calpain family cysteine protease-like protein 0.0391 0.0587 0.0744
Mycobacterium ulcerans two component regulator - sensor kinase 0.0178 0.0037 0.5
Trichomonas vaginalis heat shock protein, putative 0.0178 0.0037 0.0128
Schistosoma mansoni mitochondrial solute carrier 0.0247 0.0214 0.0214
Trichomonas vaginalis calcium binding protein, putative 0.0247 0.0214 0.0734
Leishmania major heat shock protein 83-1 0.0178 0.0037 0.0048
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0744
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1291 0.2917 0.3021
Leishmania major heat shock protein 83-1 0.0178 0.0037 0.0048
Trypanosoma brucei Calpain-like protein 2 0.0391 0.0587 0.0744
Echinococcus granulosus EF HAND 1 calcium binding site 0.0247 0.0214 0.0214
Mycobacterium tuberculosis Probable two component sensor kinase 0.0178 0.0037 0.5
Plasmodium vivax calpain, putative 0.1399 0.3196 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0607
Trichomonas vaginalis calpain, putative 0.0391 0.0587 0.2011
Echinococcus multilocularis EF hand domain containing family member A2 0.0249 0.0221 0.0221
Brugia malayi calpain family protein 1 0.3779 0.9355 0.9688
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0249 0.0221 0.0229
Leishmania major heat shock protein 83-1 0.0178 0.0037 0.0048
Trypanosoma brucei developmentally regulated phosphoprotein 0.3209 0.7879 1
Plasmodium vivax centrin-1, putative 0.0247 0.0214 0.067
Echinococcus multilocularis cathepsin b 0.3895 0.9656 0.9656
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0391 0.0587 0.1995
Plasmodium vivax hypothetical protein, conserved 0.0178 0.0037 0.0117
Schistosoma mansoni calpain-7 (C02 family) 0.1402 0.3203 0.3205
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0744
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0744
Echinococcus multilocularis calpain 0.1399 0.3196 0.3196
Leishmania major heat shock protein 83-1 0.0178 0.0037 0.0048
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.1122 0.2478 0.2567
Echinococcus granulosus EF hand domain containing family member A2 0.0249 0.0221 0.0221
Leishmania major hypothetical protein, conserved 0.0249 0.0221 0.028
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0178 0.0037 0.5
Plasmodium vivax DNA gyrase subunit B, putative 0.0178 0.0037 0.0117
Trichomonas vaginalis calcium binding protein, putative 0.0332 0.0435 0.1491
Echinococcus granulosus calbindin 32 0.0249 0.0221 0.0221
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.13 0.294 1
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0178 0.0037 0.0048
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0744
Brugia malayi cathepsin B-like cysteine proteinase 0.3895 0.9656 1
Echinococcus multilocularis centrin 2 0.0247 0.0214 0.0214
Giardia lamblia Hypothetical protein 0.0249 0.0221 0.0637
Onchocerca volvulus 0.0249 0.0221 0.0385
Echinococcus multilocularis calpain 5 0.1399 0.3196 0.3196
Loa Loa (eye worm) hypothetical protein 0.238 0.5735 0.5939
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0607
Trypanosoma brucei heat shock protein 90, putative 0.0178 0.0037 0.0048
Schistosoma mansoni ef hand domain family member A2 0.0247 0.0214 0.0214
Leishmania major heat shock protein 83-1 0.0178 0.0037 0.0048
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0178 0.0037 0.0039
Entamoeba histolytica heat shock protein 90, putative 0.0178 0.0037 0.0172
Leishmania major phospholipase c-like protein 0.0247 0.0214 0.0272
Trypanosoma brucei calpain, putative 0.0391 0.0587 0.0744
Schistosoma mansoni endoplasmin 0.0178 0.0037 0.0037
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0744
Trichomonas vaginalis calmodulin, putative 0.0247 0.0214 0.0734
Trypanosoma brucei calpain-like protein, putative 0.1399 0.3196 0.4056
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0178 0.0037 0.5
Trypanosoma brucei heat shock protein, putative 0.0178 0.0037 0.0048
Schistosoma mansoni pyruvate dehydrogenase 0.3209 0.7879 0.7884
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.1122 0.2478 0.3146
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0178 0.0037 0.0039
Entamoeba histolytica grainin, putative 0.0249 0.0221 0.1011
Trypanosoma cruzi DNA topoisomerase II, putative 0.0178 0.0037 0.0039
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0178 0.0037 0.0065
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.4026 0.9993 0.9993
Brugia malayi kinase, mitochondrial precursor 0.3209 0.7879 0.816
Entamoeba histolytica calcium binding family protein 0.0247 0.0214 0.098
Mycobacterium ulcerans putative regultory protein 0.0178 0.0037 0.5
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0607
Schistosoma mansoni reticulocalbin 0.0249 0.0221 0.0221
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0391 0.0587 0.2011
Trypanosoma brucei heat shock protein, putative 0.0178 0.0037 0.0048
Trypanosoma brucei calpain-like protein, putative 0.1399 0.3196 0.4056
Echinococcus granulosus heat shock protein 90 0.0178 0.0037 0.0037
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0744
Plasmodium vivax hypothetical protein, conserved 0.0249 0.0221 0.0691
Trypanosoma brucei hypothetical protein 0.0391 0.0587 0.0744
Trypanosoma cruzi heat shock protein 90, putative 0.0178 0.0037 0.0039
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0178 0.0037 0.5
Leishmania major hypothetical protein, unknown function 0.0391 0.0587 0.0744
Brugia malayi calpain D 0.0391 0.0587 0.0607
Brugia malayi EF hand family protein 0.0249 0.0221 0.0229
Schistosoma mansoni Mername-AA248 (C02 family) 0.1399 0.3196 0.3198
Giardia lamblia Cathepsin B precursor 0.1291 0.2917 1
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0178 0.0037 0.0128
Loa Loa (eye worm) hypothetical protein 0.0178 0.0037 0.0039
Trypanosoma cruzi I/6 autoantigen, putative 0.0247 0.0214 0.0222
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0607
Brugia malayi calpain 7 0.1399 0.3196 0.331
Loa Loa (eye worm) TOPoisomerase family member 0.0178 0.0037 0.0039
Mycobacterium ulcerans two component sensor kinase MprB 0.0178 0.0037 0.5
Leishmania major calmodulin-like protein 0.0247 0.0214 0.0272
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0607
Trypanosoma brucei centrin, putative 0.0247 0.0214 0.0272
Loa Loa (eye worm) cathepsin B 0.1291 0.2917 0.3021
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0178 0.0037 0.5
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0178 0.0037 0.0128
Trypanosoma brucei I/6 autoantigen 0.0247 0.0214 0.0272
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0178 0.0037 0.5
Brugia malayi Probable DNA topoisomerase II 0.0178 0.0037 0.0039
Trichomonas vaginalis receptor histidine kinase, putative 0.0178 0.0037 0.0128
Plasmodium falciparum DNA topoisomerase 2 0.0178 0.0037 0.0639
Echinococcus multilocularis heat shock protein 90 0.0178 0.0037 0.0037
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0178 0.0037 0.5
Echinococcus granulosus programmed cell death protein 0.0332 0.0435 0.0435
Brugia malayi calpain family protein 1 0.3779 0.9355 0.9688
Loa Loa (eye worm) hypothetical protein 0.3779 0.9355 0.9688
Echinococcus multilocularis calmodulin 0.0247 0.0214 0.0214
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0744
Leishmania major programmed cell death 6 protein-like protein 0.0247 0.0214 0.0272
Trypanosoma cruzi kinesin, putative 0.1008 0.2185 0.2263
Echinococcus multilocularis calcium uptake protein 1 0.0249 0.0221 0.0221
Echinococcus granulosus calumenin 0.0249 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0247 0.0214 0.0222
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1399 0.3196 0.331
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0744
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0178 0.0037 0.5
Loa Loa (eye worm) endoplasmin 0.0178 0.0037 0.0039
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0178 0.0037 0.5
Leishmania major centrin, putative 0.0247 0.0214 0.0272
Echinococcus granulosus calpain A 0.1399 0.3196 0.3196
Trichomonas vaginalis calpain, putative 0.0391 0.0587 0.2011
Brugia malayi heat shock protein 90 0.0178 0.0037 0.0039
Schistosoma mansoni calpain-7 (C02 family) 0.1402 0.3203 0.3205
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0391 0.0587 0.0744

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 11 % Inhibition of PDE4B (unknown origin) using FAM-cAMP as substrate at 10 uM after 60 min by fluorescence polarization assay ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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