TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 315.41 | Formula: C18H25N3O2
H donors: 0 H acceptors: 2 LogP: 2.49 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC(n1c(=O)n(CCN2CCCCC2)c2c(c1=O)cccc2)C
InChi: 1S/C18H25N3O2/c1-14(2)21-17(22)15-8-4-5-9-16(15)20(18(21)23)13-12-19-10-6-3-7-11-19/h4-5,8-9,14H,3,6-7,10-13H2,1-2H3
InChiKey: CARPJGLKKOAXIA-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	centrin, putative	0.0332	0.0435	0.0451
Trypanosoma brucei	caltractin, putative	0.0332	0.0435	0.0552
Brugia malayi	calpain 5	0.0391	0.0587	0.0607
Trichomonas vaginalis	DNA-dependent protein kinase catalytic subunit-interacting protein, putative	0.0247	0.0214	0.0734
Trypanosoma brucei	glucosamine 6-phosphate n-acetyltransferase	0.0391	0.0587	0.0744
Mycobacterium tuberculosis	Two component sensor histidine kinase TrcS	0.0178	0.0037	0.5
Trichomonas vaginalis	two component sensor and regulator histidine kinase bacteria, putative	0.0178	0.0037	0.0128
Entamoeba histolytica	protein kinase, putative	0.1008	0.2185	1
Leishmania major	centrin, putative	0.0247	0.0214	0.0272
Mycobacterium tuberculosis	Possible two component system response sensor kinase membrane associated PhoR	0.0178	0.0037	0.5
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0178	0.0037	0.0127
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0391	0.0587	0.0607
Schistosoma mansoni	hypothetical protein	0.0247	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0247	0.0214	0.0222
Echinococcus granulosus	EF hand domain containing family member A2	0.0247	0.0214	0.0214
Trypanosoma cruzi	conserved protein	0.0391	0.0587	0.0607
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0391	0.0587	0.0607
Leishmania major	calmodulin-like protein	0.0247	0.0214	0.0272
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0391	0.0587	0.0744
Trichomonas vaginalis	sensor histidine kinase, putative	0.0178	0.0037	0.0128
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0178	0.0037	0.0128
Entamoeba histolytica	calpain large subunit domain III containing protein	0.1008	0.2185	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0744
Chlamydia trachomatis	DNA gyrase subunit B	0.0178	0.0037	0.5
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0247	0.0214	0.067
Mycobacterium ulcerans	two component sensor histidine kinase SenX3	0.0178	0.0037	0.5
Trypanosoma cruzi	calmodulin, putative	0.0247	0.0214	0.0222
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0391	0.0587	0.0607
Plasmodium vivax	heat shock protein 86, putative	0.0178	0.0037	0.0117
Trichomonas vaginalis	heat shock protein, putative	0.0178	0.0037	0.0128
Echinococcus granulosus	heat shock protein	0.0178	0.0037	0.0037
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0178	0.0037	0.0127
Trypanosoma brucei	heat shock protein, putative	0.0178	0.0037	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0391	0.0587	0.0607
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.0178	0.0037	0.5
Loa Loa (eye worm)	calpain family protein 1	0.2771	0.6746	0.6986
Schistosoma mansoni	centrin-related	0.0247	0.0214	0.0214
Trypanosoma cruzi	Heat shock protein 83, putative	0.0178	0.0037	0.0039
Giardia lamblia	Cathepsin B precursor	0.1291	0.2917	1
Plasmodium vivax	endoplasmin, putative	0.0178	0.0037	0.0117
Entamoeba histolytica	grainin 2	0.0332	0.0435	0.1991
Echinococcus granulosus	neuronal calcium sensor	0.0247	0.0214	0.0214
Mycobacterium leprae	Probable two-component sensor kinase	0.0178	0.0037	0.5
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0178	0.0037	0.0128
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1399	0.3196	0.331
Echinococcus multilocularis	EF hand domain containing family member A2	0.0247	0.0214	0.0214
Schistosoma mansoni	rab	0.0247	0.0214	0.0214
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0247	0.0214	0.098
Leishmania major	calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0744
Chlamydia trachomatis	DNA gyrase subunit B	0.0178	0.0037	0.5
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1399	0.3196	0.331
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1399	0.3196	0.4056
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.3209	0.7879	0.7879
Loa Loa (eye worm)	programmed cell death protein 6	0.0249	0.0221	0.0229
Leishmania major	heat shock protein 83-1	0.0178	0.0037	0.0048
Plasmodium falciparum	heat shock protein 90	0.0178	0.0037	0.0639
Trypanosoma brucei	heat shock protein, putative	0.0178	0.0037	0.0048
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0391	0.0587	0.2011
Trichomonas vaginalis	conserved hypothetical protein	0.0247	0.0214	0.0734
Plasmodium falciparum	endoplasmin, putative	0.0178	0.0037	0.0639
Toxoplasma gondii	hypothetical protein	0.0391	0.0587	0.1995
Loa Loa (eye worm)	hypothetical protein	0.3895	0.9656	1
Trypanosoma brucei	CAMK/CAMKL family protein kinase, putative	0.0247	0.0214	0.0272
Trypanosoma brucei	DNA topoisomerase ii	0.0178	0.0037	0.0048
Schistosoma mansoni	endoplasmin	0.0178	0.0037	0.0037
Toxoplasma gondii	calcium-dependent protein kinase	0.0249	0.0221	0.0751
Echinococcus multilocularis	calbindin 32	0.0249	0.0221	0.0221
Echinococcus granulosus	calpain	0.1399	0.3196	0.3196
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0391	0.0587	0.0607
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0744
Trichomonas vaginalis	centrin, putative	0.0247	0.0214	0.0734
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0247	0.0214	0.0222
Echinococcus granulosus	calpain 7 C02 family	0.1399	0.3196	0.3196
Leishmania major	cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0744
Echinococcus granulosus	cathepsin b	0.3895	0.9656	0.9656
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0744
Onchocerca volvulus		0.0247	0.0214	0.0373
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3895	0.9656	0.9662
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0391	0.0587	0.0607
Trypanosoma brucei	Heat shock protein 83, putative	0.0178	0.0037	0.0048
Echinococcus granulosus	calmodulin	0.0247	0.0214	0.0214
Schistosoma mansoni	pyruvate dehydrogenase	0.303	0.7417	0.7422
Trichomonas vaginalis	hypothetical protein	0.0391	0.0587	0.2011
Loa Loa (eye worm)	calpain D	0.0391	0.0587	0.0607
Trichomonas vaginalis	endoplasmin, putative	0.0178	0.0037	0.0128
Mycobacterium tuberculosis	Two component sensor kinase MprB	0.0178	0.0037	0.5
Mycobacterium tuberculosis	Two component sensory transduction histidine kinase MtrB	0.0178	0.0037	0.5
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0247	0.0214	0.098
Loa Loa (eye worm)	calmodulin-like protein	0.0247	0.0214	0.0222
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0391	0.0587	0.2011
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1291	0.2917	0.3703
Loa Loa (eye worm)	calpain family protein 1	0.3779	0.9355	0.9688
Trypanosoma brucei	Calpain-like protein 1.2	0.0391	0.0587	0.0744
Trypanosoma cruzi	heat shock protein 85, putative	0.0178	0.0037	0.0039
Trichomonas vaginalis	calmodulin, putative	0.0247	0.0214	0.0734
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1399	0.3196	0.331
Brugia malayi	Endoplasmin precursor	0.0178	0.0037	0.0039
Echinococcus multilocularis	calpain family protein 1, d	0.2771	0.6746	0.6746
Trypanosoma brucei	mitochondrial calcium uptake 1	0.0247	0.0214	0.0272
Trypanosoma brucei	Calpain-like protein 1.1	0.0391	0.0587	0.0744
Schistosoma mansoni	calpain (C02 family)	0.1399	0.3196	0.3198
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0744
Toxoplasma gondii	heat shock protein 90, putative	0.0178	0.0037	0.0127
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1399	0.3196	0.331
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0391	0.0587	0.2011
Mycobacterium leprae	Probable two component sensor kinase MprB	0.0178	0.0037	0.5
Echinococcus multilocularis	sarcoplasmic calcium binding protein	0.0247	0.0214	0.0214
Loa Loa (eye worm)	heat shock protein 90	0.0178	0.0037	0.0039
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.4026	0.9993	0.9993
Schistosoma mansoni	calmodulin	0.0247	0.0214	0.0214
Leishmania major	heat shock protein 83-1	0.0178	0.0037	0.0048
Toxoplasma gondii	pyruvate dehydrogenase kinase, putative	0.1122	0.2478	0.8429
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1399	0.3196	0.331
Schistosoma mansoni	calpain-2 (C02 family)	0.0391	0.0587	0.0587
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0178	0.0037	0.0037
Leishmania major	i/6 autoantigen-like protein	0.0247	0.0214	0.0272
Onchocerca volvulus		0.0247	0.0214	0.0373
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.3895	0.9656	0.9662
Brugia malayi	calcium-binding protein	0.0247	0.0214	0.0222
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0391	0.0587	0.0607
Trichomonas vaginalis	myosin light chain 1, putative	0.0247	0.0214	0.0734
Plasmodium falciparum	centrin-1	0.0247	0.0214	0.3649
Loa Loa (eye worm)	hypothetical protein	0.3388	0.8344	0.8641
Plasmodium falciparum	calpain	0.0391	0.0587	1
Leishmania major	calcineurin B subunit, putative	0.0247	0.0214	0.0272
Trypanosoma brucei	calpain-like protein, putative	0.1399	0.3196	0.4056
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.3209	0.7879	0.7879
Echinococcus multilocularis	cathepsin b	0.3895	0.9656	0.9656
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0607
Leishmania major	heat shock protein 83-1	0.0178	0.0037	0.0048
Schistosoma mansoni	centrin	0.0247	0.0214	0.0214
Schistosoma mansoni	hypothetical protein	0.0391	0.0587	0.0587
Mycobacterium ulcerans	two component system membrane associated sensor kinase	0.0178	0.0037	0.5
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.1399	0.3196	0.4056
Leishmania major	calmodulin, putative	0.0247	0.0214	0.0272
Trichomonas vaginalis	sensory transduction histidine kinase, putative	0.0178	0.0037	0.0128
Toxoplasma gondii	heat shock protein HSP90	0.0178	0.0037	0.0127
Leishmania major	calmodulin, putative	0.0247	0.0214	0.0272
Echinococcus multilocularis	heat shock protein	0.0178	0.0037	0.0037
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.3779	0.9355	0.9361
Onchocerca volvulus		0.238	0.5735	1
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0247	0.0214	0.0222
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0178	0.0037	0.0048
Trichomonas vaginalis	calcineurin B subunit, putative	0.0247	0.0214	0.0734
Loa Loa (eye worm)	calpain 5	0.1008	0.2185	0.2263
Plasmodium vivax	DNA topoisomerase II, putative	0.0178	0.0037	0.0117
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0178	0.0037	0.0039
Brugia malayi	Calmodulin-like protein	0.0247	0.0214	0.0222
Trypanosoma brucei	calmodulin, putative	0.0247	0.0214	0.0272
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0744
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1399	0.3196	0.331
Trypanosoma brucei	centrin, putative	0.0247	0.0214	0.0272
Leishmania major	hypothetical protein, conserved	0.0247	0.0214	0.0272
Trichomonas vaginalis	calcium binding protein, putative	0.0247	0.0214	0.0734
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3895	0.9656	0.9662
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0178	0.0037	0.5
Schistosoma mansoni	calpain C (C02 family)	0.1399	0.3196	0.3198
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.1399	0.3196	0.4056
Loa Loa (eye worm)	hypothetical protein	0.2771	0.6746	0.6986
Trypanosoma brucei	Present in the outer mitochondrial membrane proteome 33	0.0247	0.0214	0.0272
Mycobacterium ulcerans	two component system response phosphate sensor kinase, PhoR	0.0178	0.0037	0.5
Brugia malayi	programmed cell death protein 6	0.0247	0.0214	0.0222
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3895	0.9656	0.9662
Trichomonas vaginalis	calcineurin B subunit, putative	0.0249	0.0221	0.0757
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0178	0.0037	0.0048
Echinococcus multilocularis	calmodulin	0.0247	0.0214	0.0214
Trichomonas vaginalis	calmodulin, putative	0.0249	0.0221	0.0757
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.3895	0.9656	1
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0178	0.0037	0.0039
Toxoplasma gondii	centrin, putative	0.0247	0.0214	0.0728
Mycobacterium tuberculosis	Conserved protein	0.0178	0.0037	0.5
Trypanosoma cruzi	calmodulin, putative	0.0247	0.0214	0.0222
Schistosoma mansoni	neuronal calcium sensor	0.0247	0.0214	0.0214
Leishmania major	heat shock protein 83-1	0.0178	0.0037	0.0048
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.3209	0.7879	0.7879
Entamoeba histolytica	heat shock protein 90, putative	0.0178	0.0037	0.0172
Echinococcus multilocularis	EF HAND 1, calcium binding site	0.0247	0.0214	0.0214
Trypanosoma cruzi	centrin, putative	0.0332	0.0435	0.0451
Schistosoma mansoni	heat shock protein	0.0178	0.0037	0.0037
Brugia malayi	EF hand family protein	0.0247	0.0214	0.0222
Trypanosoma brucei	heat shock protein 90, putative	0.0178	0.0037	0.0048
Trypanosoma cruzi	calmodulin, putative	0.0247	0.0214	0.0222
Trypanosoma brucei	heat shock protein, putative	0.0178	0.0037	0.0048
Entamoeba histolytica	calmodulin, putative	0.0247	0.0214	0.098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0744
Echinococcus granulosus	centrin 2	0.0247	0.0214	0.0214
Echinococcus multilocularis	programmed cell death protein	0.0332	0.0435	0.0435
Leishmania major	hypothetical protein, conserved	0.0178	0.0037	0.0048
Trypanosoma brucei	heat shock protein, putative	0.0178	0.0037	0.0048
Schistosoma mansoni	heat shock protein	0.0178	0.0037	0.0037
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0178	0.0037	0.0127
Schistosoma mansoni	neuronal calcium sensor	0.0247	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0037	0.0039
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.1291	0.2917	0.3703
Echinococcus multilocularis	calpain A	0.4029	1	1
Schistosoma mansoni	hypothetical protein	0.0247	0.0214	0.0214
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0391	0.0587	0.0607
Toxoplasma gondii	EFHC1, putative	0.0247	0.0214	0.0728
Trichomonas vaginalis	calmodulin, putative	0.0332	0.0435	0.1491
Trichomonas vaginalis	calmodulin, putative	0.0247	0.0214	0.0734
Trypanosoma brucei	pyruvate dehydrogenase (lipoamide) kinase, putative	0.1122	0.2478	0.3146
Trypanosoma cruzi	programmed cell death 6 protein-like, putative	0.0247	0.0214	0.0222
Leishmania major	heat shock protein 83-1	0.0178	0.0037	0.0048
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0247	0.0214	0.0222
Echinococcus granulosus	cathepsin b	0.3895	0.9656	0.9656
Leishmania major	heat shock protein 83-1	0.0178	0.0037	0.0048
Mycobacterium tuberculosis	Possible two component sensor kinase	0.0178	0.0037	0.5
Trichomonas vaginalis	calpain, putative	0.0391	0.0587	0.2011
Trypanosoma brucei	hypothetical protein, conserved	0.0247	0.0214	0.0272
Leishmania major	hypothetical protein, conserved	0.0391	0.0587	0.0744
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0744
Leishmania major	heat shock protein 83-1	0.0178	0.0037	0.0048
Trypanosoma cruzi	centrin-3	0.0332	0.0435	0.0451
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.1399	0.3196	0.4056
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1291	0.2917	1
Toxoplasma gondii	calmodulin CAM1	0.0249	0.0221	0.0751
Echinococcus granulosus	calcium uptake protein 1	0.0249	0.0221	0.0221
Schistosoma mansoni	calmodulin related calcium binding protein	0.0247	0.0214	0.0214
Trypanosoma cruzi	I/6 autoantigen, putative	0.0247	0.0214	0.0222
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0178	0.0037	0.5
Trichomonas vaginalis	centrin, putative	0.0247	0.0214	0.0734
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0178	0.0037	0.0037
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0178	0.0037	0.0065
Plasmodium falciparum	DNA gyrase subunit B	0.0178	0.0037	0.0639
Schistosoma mansoni	calcium binding atopy-related autoantigen	0.0249	0.0221	0.0221
Leishmania major	heat shock protein 83-1	0.0178	0.0037	0.0048
Echinococcus multilocularis	neurocalcin	0.0247	0.0214	0.0214
Echinococcus granulosus	neurocalcin	0.0247	0.0214	0.0214
Echinococcus granulosus	sarcoplasmic calcium binding protein	0.0247	0.0214	0.0214
Schistosoma mansoni	pyruvate dehydrogenase	0.303	0.7417	0.7422
Leishmania major	DNA topoisomerase ii	0.0178	0.0037	0.0048
Loa Loa (eye worm)	calpain	0.1399	0.3196	0.331
Trypanosoma brucei	kinesin, putative	0.1008	0.2185	0.2773
Entamoeba histolytica	hypothetical protein, conserved	0.0249	0.0221	0.1011
Entamoeba histolytica	calpain family cysteine protease, putative	0.0391	0.0587	0.2685
Toxoplasma gondii	EF hand domain-containing protein	0.0247	0.0214	0.0728
Leishmania major	heat shock protein 83-1	0.0178	0.0037	0.0048
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1399	0.3196	0.331
Trichomonas vaginalis	calmodulin, putative	0.0247	0.0214	0.0734
Trichomonas vaginalis	calmodulin, putative	0.0247	0.0214	0.0734
Trypanosoma cruzi	heat shock protein 85, putative	0.0178	0.0037	0.0039
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0391	0.0587	0.0607
Trichomonas vaginalis	calcium binding protein, putative	0.0247	0.0214	0.0734
Leishmania major	heat shock protein 83-1	0.0178	0.0037	0.0048
Schistosoma mansoni	mitochondrial solute carrier	0.0247	0.0214	0.0214
Trichomonas vaginalis	heat shock protein, putative	0.0178	0.0037	0.0128
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1291	0.2917	0.3021
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0744
Echinococcus granulosus	calpain 5	0.1399	0.3196	0.3196
Mycobacterium ulcerans	two component regulator - sensor kinase	0.0178	0.0037	0.5
Leishmania major	calpain family cysteine protease-like protein	0.0391	0.0587	0.0744
Echinococcus multilocularis	EF hand domain containing family member A2	0.0249	0.0221	0.0221
Trichomonas vaginalis	calpain, putative	0.0391	0.0587	0.2011
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0607
Plasmodium vivax	calpain, putative	0.1399	0.3196	1
Brugia malayi	calpain family protein 1	0.3779	0.9355	0.9688
Trypanosoma brucei	Calpain-like protein 2	0.0391	0.0587	0.0744
Leishmania major	heat shock protein 83-1	0.0178	0.0037	0.0048
Echinococcus granulosus	EF HAND 1 calcium binding site	0.0247	0.0214	0.0214
Mycobacterium tuberculosis	Probable two component sensor kinase	0.0178	0.0037	0.5
Leishmania major	calpain protease-like protein	0.0391	0.0587	0.0744
Loa Loa (eye worm)	EF hand family protein	0.0247	0.0214	0.0222
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0391	0.0587	0.0607
Leishmania major	centrin, putative,caltractin, putative	0.0247	0.0214	0.0272
Echinococcus multilocularis	calpain 7 (C02 family)	0.1399	0.3196	0.3196
Trypanosoma cruzi	heat shock protein 90, putative	0.0178	0.0037	0.0039
Trypanosoma cruzi	kinesin, putative	0.1008	0.2185	0.2263
Trichomonas vaginalis	receptor histidine kinase, putative	0.0178	0.0037	0.0128
Schistosoma mansoni	reticulocalbin	0.0247	0.0214	0.0214
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0391	0.0587	0.0607
Echinococcus multilocularis	hypothetical protein	0.1399	0.3196	0.3196
Giardia lamblia	Cathepsin B precursor	0.1291	0.2917	1
Trypanosoma brucei	centrin-3	0.0332	0.0435	0.0552
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0178	0.0037	0.0065
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0607
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0391	0.0587	0.2011
Trypanosoma brucei	Component of motile flagella 41	0.0247	0.0214	0.0272
Plasmodium falciparum	DNA topoisomerase VI, b subunit, putative	0.0178	0.0037	0.0639
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0607
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1399	0.3196	0.331
Trypanosoma cruzi	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0178	0.0037	0.0039
Trypanosoma brucei	cytoskeleton-associated protein CAP5.5, putative	0.0391	0.0587	0.0744
Wolbachia endosymbiont of Brugia malayi	membrane associated signal transduction histidine kinase	0.0178	0.0037	0.5
Brugia malayi	calpain 5	0.1008	0.2185	0.2263
Loa Loa (eye worm)	hypothetical protein	0.3209	0.7879	0.816
Schistosoma mansoni	DNA topoisomerase II	0.0178	0.0037	0.0037
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0744
Treponema pallidum	chemotaxis histidine kinase (cheA)	0.0178	0.0037	0.5
Leishmania major	heat shock protein 83-1	0.0178	0.0037	0.0048
Trichomonas vaginalis	calmodulin, putative	0.0247	0.0214	0.0734
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.4026	0.9993	1
Mycobacterium ulcerans	sensor kinase from two component regulatory system	0.0178	0.0037	0.5
Entamoeba histolytica	calmodulin, putative	0.0247	0.0214	0.098
Trichomonas vaginalis	calmodulin, putative	0.0247	0.0214	0.0734
Schistosoma mansoni	Sarcoplasmic calcium-binding protein (SCP).	0.0247	0.0214	0.0214
Mycobacterium tuberculosis	Probable sensor protein KdpD	0.0178	0.0037	0.5
Trypanosoma brucei	Calpain-like protein CALP1.3	0.0391	0.0587	0.0744
Trichomonas vaginalis	Crustacean calcium-binding protein, putative	0.0247	0.0214	0.0734
Schistosoma mansoni	neuronal calcium sensor	0.0247	0.0214	0.0214
Mycobacterium leprae	TWO COMPONENT SENSOR HISTIDINE KINASE PRRB	0.0178	0.0037	0.5
Mycobacterium tuberculosis	Possible two component sensor kinase TcrY	0.0178	0.0037	0.5
Mycobacterium ulcerans	DNA gyrase subunit B	0.0178	0.0037	0.5
Trypanosoma cruzi	caltractin, putative	0.0247	0.0214	0.0222
Trichomonas vaginalis	conserved hypothetical protein	0.0391	0.0587	0.2011
Leishmania major	heat shock protein 83-1	0.0178	0.0037	0.0048
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1291	0.2917	0.2919
Trypanosoma brucei	protein I/6	0.0247	0.0214	0.0272
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1399	0.3196	0.4056
Trypanosoma cruzi	mitochondrial calcium uptake 1, putative	0.0247	0.0214	0.0222
Schistosoma mansoni	calmodulin	0.0247	0.0214	0.0214
Leishmania major	protein kinase, putative	0.0247	0.0214	0.0272
Leishmania major	kinesin, putative	0.1008	0.2185	0.2773
Trichomonas vaginalis	calcium binding protein, putative	0.0247	0.0214	0.0734
Entamoeba histolytica	calcium-binding protein, putative	0.0247	0.0214	0.098
Toxoplasma gondii	cathepsin B	0.1291	0.2917	0.9922
Trypanosoma brucei	heat shock protein, putative	0.0178	0.0037	0.0048
Trypanosoma brucei	cysteine peptidase, putative	0.0391	0.0587	0.0744
Mycobacterium tuberculosis	Two component sensor kinase [second part]	0.0178	0.0037	0.5
Leishmania major	mitochondrial DNA topoisomerase II	0.0178	0.0037	0.0048
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.3209	0.7879	0.816
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.1399	0.3196	0.331
Mycobacterium ulcerans	two component sensor histidine kinase PrrB	0.0178	0.0037	0.5
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0178	0.0037	0.5
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0391	0.0587	0.2011
Leishmania major	heat shock protein 83-1	0.0178	0.0037	0.0048
Leishmania major	developmentally regulated phosphoprotein-like protein	0.3209	0.7879	1
Echinococcus multilocularis	calumenin	0.0249	0.0221	0.0221
Trypanosoma cruzi	heat shock protein 85, putative	0.0178	0.0037	0.0039
Trypanosoma brucei	heat shock protein, putative	0.0178	0.0037	0.0048
Echinococcus multilocularis	programmed cell death protein	0.0332	0.0435	0.0435
Trichomonas vaginalis	conserved hypothetical protein	0.0247	0.0214	0.0734
Echinococcus multilocularis	neuronal calcium sensor	0.0247	0.0214	0.0214
Trichomonas vaginalis	calcium binding proteins, putative	0.0247	0.0214	0.0734
Toxoplasma gondii	troponin c, isotype gamma, putative	0.0247	0.0214	0.0728
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.4026	0.9993	1
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0178	0.0037	0.0039
Trypanosoma brucei	calpain-like protein, putative	0.1399	0.3196	0.4056
Entamoeba histolytica	DNA topoisomerase II, putative	0.0178	0.0037	0.0172
Trypanosoma brucei	antigen, putative	0.1399	0.3196	0.4056
Trichomonas vaginalis	calmodulin-2, putative	0.0247	0.0214	0.0734
Trypanosoma brucei	calpain, putative	0.0391	0.0587	0.0744
Toxoplasma gondii	centrin	0.0247	0.0214	0.0728
Trypanosoma brucei	calmodulin, putative	0.0249	0.0221	0.028
Schistosoma mansoni	neuronal calcium sensor	0.0247	0.0214	0.0214
Echinococcus multilocularis	heat shock protein 90	0.0178	0.0037	0.0037
Plasmodium falciparum	DNA topoisomerase 2	0.0178	0.0037	0.0639
Mycobacterium tuberculosis	Two component sensor histidine kinase PrrB	0.0178	0.0037	0.5
Trichomonas vaginalis	receptor histidine kinase, putative	0.0178	0.0037	0.0128
Brugia malayi	Probable DNA topoisomerase II	0.0178	0.0037	0.0039
Echinococcus multilocularis	calcium uptake protein 1	0.0249	0.0221	0.0221
Trypanosoma cruzi	kinesin, putative	0.1008	0.2185	0.2263
Echinococcus granulosus	programmed cell death protein	0.0332	0.0435	0.0435
Leishmania major	programmed cell death 6 protein-like protein	0.0247	0.0214	0.0272
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0744
Brugia malayi	calpain family protein 1	0.3779	0.9355	0.9688
Echinococcus multilocularis	calmodulin	0.0247	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.3779	0.9355	0.9688
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0178	0.0037	0.5
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0744
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1399	0.3196	0.331
Echinococcus granulosus	calumenin	0.0249	0.0221	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0247	0.0214	0.0222
Echinococcus granulosus	calpain A	0.1399	0.3196	0.3196
Leishmania major	centrin, putative	0.0247	0.0214	0.0272
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0744
Schistosoma mansoni	calpain-7 (C02 family)	0.1402	0.3203	0.3205
Brugia malayi	heat shock protein 90	0.0178	0.0037	0.0039
Trichomonas vaginalis	calpain, putative	0.0391	0.0587	0.2011
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0178	0.0037	0.5
Loa Loa (eye worm)	endoplasmin	0.0178	0.0037	0.0039
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0744
Echinococcus granulosus	heat shock protein 90	0.0178	0.0037	0.0037
Plasmodium vivax	hypothetical protein, conserved	0.0249	0.0221	0.0691
Trypanosoma brucei	calpain-like protein, putative	0.1399	0.3196	0.4056
Leishmania major	hypothetical protein, unknown function	0.0391	0.0587	0.0744
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.0178	0.0037	0.5
Trypanosoma cruzi	heat shock protein 90, putative	0.0178	0.0037	0.0039
Trypanosoma brucei	hypothetical protein	0.0391	0.0587	0.0744
Schistosoma mansoni	reticulocalbin	0.0249	0.0221	0.0221
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0391	0.0587	0.2011
Trypanosoma brucei	heat shock protein, putative	0.0178	0.0037	0.0048
Schistosoma mansoni	Mername-AA248 (C02 family)	0.1399	0.3196	0.3198
Brugia malayi	calpain D	0.0391	0.0587	0.0607
Brugia malayi	EF hand family protein	0.0249	0.0221	0.0229
Giardia lamblia	Cathepsin B precursor	0.1291	0.2917	1
Loa Loa (eye worm)	TOPoisomerase family member	0.0178	0.0037	0.0039
Trichomonas vaginalis	mismatch repair protein Mlh1C (mutL homolog)	0.0178	0.0037	0.0128
Brugia malayi	calpain 7	0.1399	0.3196	0.331
Trypanosoma cruzi	I/6 autoantigen, putative	0.0247	0.0214	0.0222
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0037	0.0039
Mycobacterium ulcerans	two component sensor histidine kinase TrcS	0.0178	0.0037	0.5
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0178	0.0037	0.0128
Trypanosoma brucei	I/6 autoantigen	0.0247	0.0214	0.0272
Wolbachia endosymbiont of Brugia malayi	signal transduction histidine kinase and receiver	0.0178	0.0037	0.5
Leishmania major	calmodulin-like protein	0.0247	0.0214	0.0272
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0607
Mycobacterium ulcerans	two component sensor kinase MprB	0.0178	0.0037	0.5
Trypanosoma brucei	centrin, putative	0.0247	0.0214	0.0272
Loa Loa (eye worm)	cathepsin B	0.1291	0.2917	0.3021
Leishmania major	phospholipase c-like protein	0.0247	0.0214	0.0272
Trypanosoma brucei	calpain, putative	0.0391	0.0587	0.0744
Schistosoma mansoni	endoplasmin	0.0178	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.238	0.5735	0.5939
Echinococcus multilocularis	calpain 5	0.1399	0.3196	0.3196
Entamoeba histolytica	heat shock protein 90, putative	0.0178	0.0037	0.0172
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0607
Trypanosoma brucei	heat shock protein 90, putative	0.0178	0.0037	0.0048
Leishmania major	heat shock protein 83-1	0.0178	0.0037	0.0048
Schistosoma mansoni	ef hand domain family member A2	0.0247	0.0214	0.0214
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0178	0.0037	0.0039
Trypanosoma brucei	heat shock protein, putative	0.0178	0.0037	0.0048
Mycobacterium leprae	PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3	0.0178	0.0037	0.5
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0178	0.0037	0.0039
Leishmania major	pyruvate dehydrogenase (lipoamide) kinase, putative	0.1122	0.2478	0.3146
Schistosoma mansoni	pyruvate dehydrogenase	0.3209	0.7879	0.7884
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0744
Trypanosoma brucei	calpain-like protein, putative	0.1399	0.3196	0.4056
Trichomonas vaginalis	calmodulin, putative	0.0247	0.0214	0.0734
Entamoeba histolytica	grainin, putative	0.0249	0.0221	0.1011
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0178	0.0037	0.0039
Entamoeba histolytica	calcium binding family protein	0.0247	0.0214	0.098
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0607
Mycobacterium ulcerans	putative regultory protein	0.0178	0.0037	0.5
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0178	0.0037	0.0065
Brugia malayi	kinase, mitochondrial precursor	0.3209	0.7879	0.816
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.4026	0.9993	0.9993
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0744
Plasmodium vivax	hypothetical protein, conserved	0.0178	0.0037	0.0117
Echinococcus multilocularis	cathepsin b	0.3895	0.9656	0.9656
Schistosoma mansoni	calpain-7 (C02 family)	0.1402	0.3203	0.3205
Toxoplasma gondii	calpain family cysteine protease domain-containing protein	0.0391	0.0587	0.1995
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0744
Leishmania major	heat shock protein 83-1	0.0178	0.0037	0.0048
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0249	0.0221	0.0229
Trypanosoma brucei	developmentally regulated phosphoprotein	0.3209	0.7879	1
Plasmodium vivax	centrin-1, putative	0.0247	0.0214	0.067
Trypanosoma cruzi	pyruvate dehydrogenase (lipoamide) kinase, putative	0.1122	0.2478	0.2567
Echinococcus granulosus	EF hand domain containing family member A2	0.0249	0.0221	0.0221
Echinococcus multilocularis	calpain	0.1399	0.3196	0.3196
Leishmania major	heat shock protein 83-1	0.0178	0.0037	0.0048
Plasmodium vivax	DNA gyrase subunit B, putative	0.0178	0.0037	0.0117
Trichomonas vaginalis	calcium binding protein, putative	0.0332	0.0435	0.1491
Mycobacterium ulcerans	two component sensory transduction histidine kinase MtrB	0.0178	0.0037	0.5
Leishmania major	hypothetical protein, conserved	0.0249	0.0221	0.028
Echinococcus multilocularis	centrin 2	0.0247	0.0214	0.0214
Brugia malayi	cathepsin B-like cysteine proteinase	0.3895	0.9656	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0391	0.0587	0.0744
Trypanosoma brucei	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0178	0.0037	0.0048
Giardia lamblia	Hypothetical protein	0.0249	0.0221	0.0637
Onchocerca volvulus		0.0249	0.0221	0.0385
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.13	0.294	1
Echinococcus granulosus	calbindin 32	0.0249	0.0221	0.0221

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3438887

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1930937