TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 353.844 | Formula: C17H24ClN3O3
H donors: 2 H acceptors: 3 LogP: -0.88 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCCN(CC1)CC(C(=O)O)CC(=O)Nc1ccc(cc1)Cl
InChi: 1S/C17H24ClN3O3/c1-20-7-2-8-21(10-9-20)12-13(17(23)24)11-16(22)19-15-5-3-14(18)4-6-15/h3-6,13H,2,7-12H2,1H3,(H,19,22)(H,23,24)
InChiKey: NGSDAXKDGOCOOC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Cathepsin L-like precursor	0.017	0.004	0.0042
Echinococcus multilocularis	sarcoplasmic calcium binding protein	0.0255	0.0254	0.0214
Trypanosoma cruzi	cysteine peptidase, putative	0.017	0.004	0.0042
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.1835
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.0647
Schistosoma mansoni	cathepsin F (C01 family)	0.017	0.004	0.004
Brugia malayi	Cathepsin L-like precursor	0.017	0.004	0.0042
Brugia malayi	programmed cell death protein 6	0.0255	0.0254	0.0263
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.1835
Entamoeba histolytica	cysteine protease, putative	0.017	0.004	0.0182
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.004	0.0137
Toxoplasma gondii	troponin c, isotype gamma, putative	0.0255	0.0254	0.0734
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0255	0.0254	0.067
Echinococcus multilocularis	calbindin 32	0.0258	0.026	0.0221
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.4163	0.9993	0.9993
Schistosoma mansoni	centrin	0.0255	0.0254	0.0254
Trypanosoma brucei	Calpain-like protein 1.2	0.0404	0.0625	0.1835
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.004	0.0137
Loa Loa (eye worm)	ctsf protein	0.017	0.004	0.0042
Brugia malayi	calpain 5	0.1043	0.2216	0.2295
Echinococcus granulosus	cathepsin l1	0.017	0.004	0.004
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0255	0.0254	0.1144
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0404	0.0625	0.1835
Trypanosoma cruzi	calmodulin, putative	0.0255	0.0254	0.0263
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0255	0.0254	0.0263
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1335	0.2946	1
Schistosoma mansoni	neuronal calcium sensor	0.0255	0.0254	0.0254
Schistosoma mansoni	Sarcoplasmic calcium-binding protein (SCP).	0.0255	0.0254	0.0254
Leishmania major	hypothetical protein, conserved	0.0258	0.026	0.0691
Loa Loa (eye worm)	hypothetical protein	0.2865	0.6759	0.6999
Toxoplasma gondii	calpain family cysteine protease domain-containing protein	0.0404	0.0625	0.2011
Echinococcus multilocularis	calpain family protein 1, d	0.2865	0.6759	0.6746
Echinococcus multilocularis	calpain	0.1447	0.3223	0.3196
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.004	0.0137
Onchocerca volvulus	Cathepsin F homolog	0.017	0.004	0.007
Entamoeba histolytica	cysteine proteinase, putative	0.017	0.004	0.0182
Loa Loa (eye worm)	calmodulin-like protein	0.0255	0.0254	0.0263
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1447	0.3223	0.3338
Brugia malayi	EF hand family protein	0.0255	0.0254	0.0263
Echinococcus multilocularis	calcium uptake protein 1	0.0258	0.026	0.0221
Trypanosoma brucei	mitochondrial calcium uptake 1	0.0255	0.0254	0.067
Leishmania major	calmodulin, putative	0.0255	0.0254	0.067
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.4163	0.9993	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1335	0.2946	0.2948
Trypanosoma cruzi	mitochondrial calcium uptake 1, putative	0.0255	0.0254	0.0263
Echinococcus granulosus	EF hand domain containing family member A2	0.0258	0.026	0.026
Trichomonas vaginalis	centrin, putative	0.0255	0.0254	0.0861
Trypanosoma brucei	protein I/6	0.0255	0.0254	0.067
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.1835
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.004	0.0137
Plasmodium vivax	centrin-1, putative	0.0255	0.0254	0.067
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1447	0.3223	0.3338
Leishmania major	i/6 autoantigen-like protein	0.0255	0.0254	0.067
Echinococcus granulosus	calpain 5	0.1447	0.3223	0.3223
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.0647
Entamoeba histolytica	hypothetical protein, conserved	0.0258	0.026	0.1175
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.1835
Loa Loa (eye worm)	fibroinase	0.017	0.004	0.0042
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.0647
Trichomonas vaginalis	calmodulin, putative	0.0255	0.0254	0.0861
Leishmania major	hypothetical protein, conserved	0.0404	0.0625	0.1835
Onchocerca volvulus		0.0255	0.0254	0.0441
Toxoplasma gondii	calcium-dependent protein kinase	0.0258	0.026	0.0757
Giardia lamblia	Cathepsin B precursor	0.1335	0.2946	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.3908	0.9357	0.9364
Toxoplasma gondii	cathepsin B	0.1335	0.2946	1
Onchocerca volvulus		0.017	0.004	0.007
Leishmania major	cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.1835
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0255	0.0254	0.0263
Onchocerca volvulus		0.017	0.004	0.007
Loa Loa (eye worm)	calpain 5	0.1043	0.2216	0.2295
Trypanosoma cruzi	centrin-3	0.0343	0.0474	0.0491
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.017	0.004	0.0137
Leishmania major	calpain family cysteine protease-like protein	0.0404	0.0625	0.1835
Brugia malayi	calpain D	0.0404	0.0625	0.0647
Echinococcus granulosus	calcium uptake protein 1	0.0258	0.026	0.026
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0404	0.0625	0.212
Schistosoma mansoni	calpain-2 (C02 family)	0.0404	0.0625	0.0625
Onchocerca volvulus		0.017	0.004	0.007
Giardia lamblia	Cathepsin B precursor	0.1335	0.2946	1
Trypanosoma cruzi	calmodulin, putative	0.0255	0.0254	0.0263
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0404	0.0625	0.0647
Trypanosoma brucei	Calpain-like protein CALP1.3	0.0404	0.0625	0.1835
Schistosoma mansoni	ef hand domain family member A2	0.0255	0.0254	0.0254
Echinococcus granulosus	calpain	0.1447	0.3223	0.3223
Trypanosoma brucei	cytoskeleton-associated protein CAP5.5, putative	0.0404	0.0625	0.1835
Trichomonas vaginalis	calpain, putative	0.0404	0.0625	0.212
Plasmodium vivax	calpain, putative	0.1447	0.3223	1
Echinococcus granulosus	calpain A	0.1447	0.3223	0.3223
Echinococcus granulosus	centrin 2	0.0255	0.0254	0.0254
Loa Loa (eye worm)	calpain D	0.0404	0.0625	0.0647
Trichomonas vaginalis	calmodulin, putative	0.0343	0.0474	0.1608
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.1835
Echinococcus granulosus	calpain 7 C02 family	0.1447	0.3223	0.3223
Brugia malayi	calcium-binding protein	0.0255	0.0254	0.0263
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.004	0.0137
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0404	0.0625	0.0647
Schistosoma mansoni	calpain-7 (C02 family)	0.1447	0.3223	0.3225
Schistosoma mansoni	Mername-AA248 (C02 family)	0.1447	0.3223	0.3225
Giardia lamblia	Cathepsin B precursor	0.1335	0.2946	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.017	0.004	0.004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.004	0.0137
Trypanosoma brucei	Calpain-like protein 2	0.0404	0.0625	0.1835
Echinococcus granulosus	neurocalcin	0.0255	0.0254	0.0254
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0404	0.0625	0.0647
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.004	0.0137
Loa Loa (eye worm)	hypothetical protein	0.2461	0.5752	0.5956
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.4163	0.9993	0.9993
Trypanosoma cruzi	CAMK/CAMKL family protein kinase, putative	0.0255	0.0254	0.0263
Trypanosoma cruzi	centrin, putative	0.0343	0.0474	0.0491
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.004	0.0137
Echinococcus multilocularis	neuronal calcium sensor	0.0255	0.0254	0.0214
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.1447	0.3223	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.004	0.0137
Entamoeba histolytica	calpain family cysteine protease, putative	0.0404	0.0625	0.2818
Echinococcus multilocularis	neurocalcin	0.0255	0.0254	0.0214
Echinococcus multilocularis	calmodulin	0.0255	0.0254	0.0214
Onchocerca volvulus		0.017	0.004	0.007
Loa Loa (eye worm)	calpain family protein 1	0.2865	0.6759	0.6999
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.1835
Echinococcus granulosus	cathepsin b	0.4028	0.9657	0.9657
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1447	0.3223	1
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0404	0.0625	0.212
Trypanosoma cruzi	centrin, putative	0.0343	0.0474	0.0491
Trichomonas vaginalis	calcineurin B subunit, putative	0.0258	0.026	0.0884
Leishmania major	kinesin, putative	0.1043	0.2216	0.6836
Trypanosoma cruzi	conserved protein	0.0404	0.0625	0.0647
Trichomonas vaginalis	calmodulin, putative	0.0255	0.0254	0.0861
Echinococcus multilocularis	cathepsin b	0.4028	0.9657	0.9656
Onchocerca volvulus		0.0255	0.0254	0.0441
Trichomonas vaginalis	centrin, putative	0.0255	0.0254	0.0861
Brugia malayi	Papain family cysteine protease containing protein	0.017	0.004	0.0042
Entamoeba histolytica	EF-hand calcium-binding domain containing protein	0.0255	0.0254	0.1144
Trichomonas vaginalis	calmodulin, putative	0.0258	0.026	0.0884
Echinococcus multilocularis	calumenin	0.0258	0.026	0.0221
Entamoeba histolytica	calcium-binding protein, putative	0.0255	0.0254	0.1144
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.0647
Loa Loa (eye worm)	calpain family protein 1	0.3908	0.9357	0.969
Trichomonas vaginalis	DNA-dependent protein kinase catalytic subunit-interacting protein, putative	0.0255	0.0254	0.0861
Brugia malayi	calpain family protein 1	0.3908	0.9357	0.969
Trichomonas vaginalis	calmodulin, putative	0.0255	0.0254	0.0861
Schistosoma mansoni	hypothetical protein	0.0404	0.0625	0.0625
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.004	0.0137
Trypanosoma cruzi	cysteine peptidase, putative	0.017	0.004	0.0042
Schistosoma mansoni	neuronal calcium sensor	0.0255	0.0254	0.0254
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.1447	0.3223	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1447	0.3223	0.3338
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.1835
Loa Loa (eye worm)	programmed cell death protein 6	0.0258	0.026	0.027
Schistosoma mansoni	calpain C (C02 family)	0.1447	0.3223	0.3225
Echinococcus multilocularis	EF hand domain containing family member A2	0.0258	0.026	0.0221
Leishmania major	phospholipase c-like protein	0.0255	0.0254	0.067
Brugia malayi	Cathepsin L-like precursor	0.017	0.004	0.0042
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0404	0.0625	0.0647
Leishmania major	hypothetical protein, unknown function	0.0404	0.0625	0.1835
Echinococcus multilocularis	EF HAND 1, calcium binding site	0.0255	0.0254	0.0214
Trypanosoma brucei	calpain-like protein, putative	0.1447	0.3223	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0404	0.0625	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0255	0.0254	0.0263
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.017	0.004	0.0137
Trypanosoma brucei	calpain, putative	0.0404	0.0625	0.1835
Echinococcus granulosus	programmed cell death protein	0.0343	0.0474	0.0474
Onchocerca volvulus		0.0258	0.026	0.0453
Echinococcus multilocularis	hypothetical protein	0.1447	0.3223	0.3196
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.1835
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.1835
Trypanosoma brucei	centrin-3	0.0343	0.0474	0.1361
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.004	0.0137
Echinococcus granulosus	sarcoplasmic calcium binding protein	0.0255	0.0254	0.0254
Trypanosoma cruzi	kinesin, putative	0.1043	0.2216	0.2295
Echinococcus granulosus	EF hand domain containing family member A2	0.0255	0.0254	0.0254
Onchocerca volvulus		0.017	0.004	0.007
Schistosoma mansoni	hypothetical protein	0.0255	0.0254	0.0254
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0404	0.0625	0.212
Leishmania major	calmodulin-like protein	0.0255	0.0254	0.067
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1447	0.3223	0.3338
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.004	0.0137
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.004	0.0137
Trichomonas vaginalis	calcium binding protein, putative	0.0255	0.0254	0.0861
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.4028	0.9657	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4028	0.9657	0.9664
Trypanosoma brucei	glucosamine 6-phosphate n-acetyltransferase	0.0404	0.0625	0.1835
Schistosoma mansoni	centrin-related	0.0255	0.0254	0.0254
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.0647
Leishmania major	centrin, putative	0.0255	0.0254	0.067
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1335	0.2946	0.9129
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.0647
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1335	0.2946	0.305
Schistosoma mansoni	reticulocalbin	0.0258	0.026	0.0261
Loa Loa (eye worm)	EF hand family protein	0.0255	0.0254	0.0263
Trichomonas vaginalis	hypothetical protein	0.0404	0.0625	0.212
Entamoeba histolytica	grainin 2	0.0343	0.0474	0.2137
Entamoeba histolytica	calpain large subunit domain III containing protein	0.1043	0.2216	1
Loa Loa (eye worm)	hypothetical protein	0.3908	0.9357	0.969
Brugia malayi	calpain 5	0.0404	0.0625	0.0647
Trypanosoma brucei	Component of motile flagella 41	0.0255	0.0254	0.067
Trypanosoma brucei	Present in the outer mitochondrial membrane proteome 33	0.0255	0.0254	0.067
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.004	0.0137
Leishmania major	calpain protease-like protein	0.0404	0.0625	0.1835
Trichomonas vaginalis	calmodulin, putative	0.0255	0.0254	0.0861
Trichomonas vaginalis	calpain, putative	0.0404	0.0625	0.212
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1447	0.3223	0.3338
Trypanosoma brucei	hypothetical protein	0.0404	0.0625	0.1835
Schistosoma mansoni	calcium binding atopy-related autoantigen	0.0258	0.026	0.0261
Loa Loa (eye worm)	cathepsin B	0.1335	0.2946	0.305
Trypanosoma brucei	antigen, putative	0.1447	0.3223	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1447	0.3223	0.3338
Echinococcus multilocularis	programmed cell death protein	0.0343	0.0474	0.0435
Schistosoma mansoni	neuronal calcium sensor	0.0255	0.0254	0.0254
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.0647
Trypanosoma cruzi	calmodulin, putative	0.0255	0.0254	0.0263
Trypanosoma brucei	calpain-like protein, putative	0.1447	0.3223	1
Schistosoma mansoni	mitochondrial solute carrier	0.0255	0.0254	0.0254
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.1835
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.1447	0.3223	1
Trichomonas vaginalis	calpain, putative	0.0404	0.0625	0.212
Leishmania major	hypothetical protein, conserved	0.0255	0.0254	0.067
Echinococcus multilocularis	cathepsin b	0.4028	0.9657	0.9656
Trichomonas vaginalis	calmodulin, putative	0.0255	0.0254	0.0861
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.4163	0.9993	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.004	0.0137
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0404	0.0625	0.0647
Trichomonas vaginalis	conserved hypothetical protein	0.0255	0.0254	0.0861
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.1835
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0404	0.0625	0.212
Schistosoma mansoni	calmodulin	0.0255	0.0254	0.0254
Trypanosoma brucei	Calpain-like protein 1.1	0.0404	0.0625	0.1835
Plasmodium vivax	hypothetical protein, conserved	0.0258	0.026	0.0691
Trypanosoma cruzi	caltractin, putative	0.0255	0.0254	0.0263
Brugia malayi	EF hand family protein	0.0258	0.026	0.027
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.1835
Leishmania major	protein kinase, putative	0.0255	0.0254	0.067
Trypanosoma brucei	cysteine peptidase, putative	0.0404	0.0625	0.1835
Trichomonas vaginalis	conserved hypothetical protein	0.0404	0.0625	0.212
Leishmania major	calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.1835
Loa Loa (eye worm)	cysteine protease	0.017	0.004	0.0042
Onchocerca volvulus		0.017	0.004	0.007
Trichomonas vaginalis	calcium binding protein, putative	0.0343	0.0474	0.1608
Trypanosoma brucei	calpain, putative	0.0404	0.0625	0.1835
Echinococcus granulosus	neuronal calcium sensor	0.0255	0.0254	0.0254
Trypanosoma cruzi	cytoskeleton-associated protein CAP5.5, putative	0.0404	0.0625	0.0647
Echinococcus granulosus	cathepsin L cysteine proteinase	0.017	0.004	0.004
Trypanosoma brucei	hypothetical protein, conserved	0.0255	0.0254	0.067
Toxoplasma gondii	centrin, putative	0.0255	0.0254	0.0734
Toxoplasma gondii	centrin	0.0255	0.0254	0.0734
Toxoplasma gondii	EF hand domain-containing protein	0.0255	0.0254	0.0734
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.1335	0.2946	0.9129
Loa Loa (eye worm)	hypothetical protein	0.0404	0.0625	0.0647
Trypanosoma brucei	calmodulin, putative	0.0258	0.026	0.0691
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.0647
Trypanosoma cruzi	cruzipain precursor, putative	0.017	0.004	0.0042
Brugia malayi	calpain 7	0.1447	0.3223	0.3338
Entamoeba histolytica	cysteine proteinase, putative	0.017	0.004	0.0182
Entamoeba histolytica	calmodulin, putative	0.0255	0.0254	0.1144
Echinococcus granulosus	cathepsin b	0.4028	0.9657	0.9657
Echinococcus multilocularis	programmed cell death protein	0.0343	0.0474	0.0435
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.004	0.0137
Trichomonas vaginalis	Crustacean calcium-binding protein, putative	0.0255	0.0254	0.0861
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.1835
Echinococcus multilocularis	calpain 7 (C02 family)	0.1447	0.3223	0.3196
Trichomonas vaginalis	calcium binding proteins, putative	0.0255	0.0254	0.0861
Schistosoma mansoni	calpain-7 (C02 family)	0.1447	0.3223	0.3225
Onchocerca volvulus	Cathepsin L homolog	0.017	0.004	0.007
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.004	0.0137
Trichomonas vaginalis	calcium binding protein, putative	0.0255	0.0254	0.0861
Trypanosoma brucei	centrin, putative	0.0255	0.0254	0.067
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.1835
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.1447	0.3223	0.3338
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 33	0.0258	0.026	0.027
Leishmania major	centrin, putative,caltractin, putative	0.0255	0.0254	0.067
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.1835
Trichomonas vaginalis	calmodulin, putative	0.0255	0.0254	0.0861
Schistosoma mansoni	calmodulin related calcium binding protein	0.0255	0.0254	0.0254
Leishmania major	centrin, putative	0.0255	0.0254	0.067
Toxoplasma gondii	calmodulin CAM1	0.0258	0.026	0.0757
Trichomonas vaginalis	calcium binding protein, putative	0.0255	0.0254	0.0861
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0404	0.0625	0.0647
Echinococcus granulosus	calumenin	0.0258	0.026	0.026
Trypanosoma brucei	calmodulin, putative	0.0255	0.0254	0.067
Trypanosoma cruzi	I/6 autoantigen, putative	0.0255	0.0254	0.0263
Leishmania major	calcineurin B subunit, putative	0.0255	0.0254	0.067
Trypanosoma cruzi	I/6 autoantigen, putative	0.0255	0.0254	0.0263
Entamoeba histolytica	protein kinase, putative	0.1043	0.2216	1
Trichomonas vaginalis	calcineurin B subunit, putative	0.0255	0.0254	0.0861
Echinococcus multilocularis	calpain A	0.4166	1	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.1835
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.004	0.0137
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.004	0.0137
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.004	0.0137
Echinococcus multilocularis	EF hand domain containing family member A2	0.0255	0.0254	0.0214
Entamoeba histolytica	grainin, putative	0.0258	0.026	0.1175
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.004	0.0137
Leishmania major	calmodulin, putative	0.0255	0.0254	0.067
Trichomonas vaginalis	myosin light chain 1, putative	0.0255	0.0254	0.0861
Trypanosoma cruzi	kinesin, putative	0.1043	0.2216	0.2295
Trypanosoma brucei	kinesin, putative	0.1043	0.2216	0.6836
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0404	0.0625	0.1835
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.017	0.004	0.0042
Echinococcus granulosus	calmodulin	0.0255	0.0254	0.0254
Plasmodium falciparum	calpain	0.0404	0.0625	1
Echinococcus granulosus	calbindin 32	0.0258	0.026	0.026
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0404	0.0625	0.0647
Brugia malayi	Cathepsin L-like precursor	0.017	0.004	0.0042
Loa Loa (eye worm)	hypothetical protein	0.4028	0.9657	1
Toxoplasma gondii	EFHC1, putative	0.0255	0.0254	0.0734
Loa Loa (eye worm)	calpain	0.1447	0.3223	0.3338
Trypanosoma cruzi	cysteine peptidase, putative	0.017	0.004	0.0042
Trichomonas vaginalis	conserved hypothetical protein	0.0255	0.0254	0.0861
Trichomonas vaginalis	calmodulin-2, putative	0.0255	0.0254	0.0861
Echinococcus multilocularis	centrin 2	0.0255	0.0254	0.0214
Trypanosoma cruzi	cysteine peptidase, putative	0.017	0.004	0.0042
Trypanosoma brucei	CAMK/CAMKL family protein kinase, putative	0.0255	0.0254	0.067
Trypanosoma brucei	calpain-like protein, putative	0.1447	0.3223	1
Onchocerca volvulus		0.2461	0.5752	1
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0404	0.0625	0.0647
Entamoeba histolytica	calmodulin, putative	0.0255	0.0254	0.1144
Onchocerca volvulus		0.017	0.004	0.007
Loa Loa (eye worm)	hypothetical protein	0.3504	0.8351	0.8647
Trypanosoma cruzi	programmed cell death 6 protein-like, putative	0.0255	0.0254	0.0263
Brugia malayi	calpain family protein 1	0.3908	0.9357	0.969
Schistosoma mansoni	calpain (C02 family)	0.1447	0.3223	0.3225
Schistosoma mansoni	calmodulin	0.0255	0.0254	0.0254
Toxoplasma gondii	hypothetical protein	0.0404	0.0625	0.2011
Leishmania major	calmodulin-like protein	0.0255	0.0254	0.067
Entamoeba histolytica	calcium binding family protein	0.0255	0.0254	0.1144
Brugia malayi	Cathepsin L-like precursor	0.017	0.004	0.0042
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.1447	0.3223	0.3338
Schistosoma mansoni	reticulocalbin	0.0255	0.0254	0.0254
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4028	0.9657	0.9664
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0404	0.0625	0.212
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0404	0.0625	0.212
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.004	0.0137
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1447	0.3223	0.3338
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.1447	0.3223	0.3338
Brugia malayi	Cathepsin L-like precursor	0.017	0.004	0.0042
Schistosoma mansoni	rab	0.0255	0.0254	0.0254
Brugia malayi	Calmodulin-like protein	0.0255	0.0254	0.0263
Schistosoma mansoni	cathepsin F (C01 family)	0.017	0.004	0.004
Echinococcus multilocularis	calpain 5	0.1447	0.3223	0.3196
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.4028	0.9657	0.9664
Plasmodium falciparum	centrin-1	0.0255	0.0254	0.3649
Echinococcus granulosus	EF HAND 1 calcium binding site	0.0255	0.0254	0.0254
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.1447	0.3223	1
Trypanosoma brucei	caltractin, putative	0.0343	0.0474	0.1361
Schistosoma mansoni	neuronal calcium sensor	0.0255	0.0254	0.0254
Schistosoma mansoni	hypothetical protein	0.0255	0.0254	0.0254
Onchocerca volvulus	Cathepsin L homolog	0.017	0.004	0.007
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.017	0.004	0.0042
Trypanosoma brucei	I/6 autoantigen	0.0255	0.0254	0.067
Trypanosoma brucei	centrin, putative	0.0255	0.0254	0.067
Trypanosoma brucei	calpain-like protein, putative	0.1447	0.3223	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.004	0.0137
Brugia malayi	cathepsin B-like cysteine proteinase	0.4028	0.9657	1
Echinococcus multilocularis	calmodulin	0.0255	0.0254	0.0214
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4028	0.9657	0.9664
Loa Loa (eye worm)	hypothetical protein	0.017	0.004	0.0042
Trichomonas vaginalis	calmodulin, putative	0.0255	0.0254	0.0861
Loa Loa (eye worm)	hypothetical protein	0.0255	0.0254	0.0263
Leishmania major	programmed cell death 6 protein-like protein	0.0255	0.0254	0.067

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3438889

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1930939