Detailed information for compound 312171

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 253.723 | Formula: C13H15ClFN2-
  • H donors: 0 H acceptors: 1 LogP: 2.86 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCC(CC1)(C#N)c1ccc(cc1)F.[Cl-]
  • InChi: 1S/C13H15FN2.ClH/c1-16-8-6-13(10-15,7-9-16)11-2-4-12(14)5-3-11;/h2-5H,6-9H2,1H3;1H/p-1
  • InChiKey: ARCQPYKYHNUIAO-UHFFFAOYSA-M  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum sodium- and chloride- dependent transporter 0.0073 0.0119 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0027 0.0027
Onchocerca volvulus 0.0205 0.0438 0.1261
Entamoeba histolytica cysteine protease, putative 0.0205 0.0438 0.3046
Loa Loa (eye worm) hypothetical protein 0.2334 0.5595 0.5595
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2334 0.5595 0.5595
Giardia lamblia Hypothetical protein 0.0146 0.0296 0.087
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0571 0.1324 0.1324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.1324 0.39
Echinococcus granulosus cathepsin L cysteine protease 0.0353 0.0797 0.0797
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.1662
Onchocerca volvulus 0.0422 0.0965 0.2777
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0571 0.1324 0.39
Trichomonas vaginalis calmodulin, putative 0.0146 0.0296 0.087
Giardia lamblia Cysteine protease 0.0205 0.0438 0.1291
Loa Loa (eye worm) hypothetical protein 0.0143 0.0289 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.0205 0.0438 0.1291
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0571 0.1324 0.39
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0027 0.008
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.0564
Trypanosoma brucei calpain-like protein, putative 0.0875 0.2061 0.607
Brugia malayi Cathepsin L-like precursor 0.0148 0.0301 0.0301
Schistosoma mansoni Mername-AA248 (C02 family) 0.0875 0.2061 0.2061
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0422 0.0965 0.0965
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0013
Trypanosoma cruzi cysteine peptidase, putative 0.0571 0.1324 0.1324
Toxoplasma gondii EF hand domain-containing protein 0.0143 0.0289 0.0851
Trichomonas vaginalis calcineurin B subunit, putative 0.0146 0.0296 0.087
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0205 0.0438 0.3046
Leishmania major hypothetical protein, unknown function 0.0257 0.0564 0.1662
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.1324 0.39
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0875 0.2061 0.2061
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0257 0.0564 0.0564
Leishmania major centrin, putative 0.0143 0.0289 0.0851
Loa Loa (eye worm) hypothetical protein 0.0205 0.0438 0.0438
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.0564
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0205 0.0438 0.2126
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0205 0.0438 0.3309
Brugia malayi EF hand family protein 0.0143 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0205 0.0438 0.0438
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0571 0.1324 0.39
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.0564
Brugia malayi calpain 7 0.0875 0.2061 0.2061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.1324 0.39
Trypanosoma brucei cysteine peptidase C (CPC) 0.1426 0.3395 1
Echinococcus multilocularis EF hand domain containing family member A2 0.0146 0.0296 0.0296
Trichomonas vaginalis calcium binding proteins, putative 0.0143 0.0289 0.0851
Loa Loa (eye worm) hypothetical protein 0.1459 0.3475 0.3475
Trypanosoma cruzi calmodulin, putative 0.0143 0.0289 0.0289
Mycobacterium ulcerans hypothetical protein 0.0035 0.0027 0.5
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.1662
Onchocerca volvulus 0.0143 0.0289 0.0832
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0571 0.1324 1
Echinococcus multilocularis calpain 5 0.0875 0.2061 0.2061
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0205 0.0438 0.2126
Echinococcus granulosus calmodulin 0.0143 0.0289 0.0289
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.2477 0.5942 0.5942
Brugia malayi Cathepsin L-like precursor 0.0571 0.1324 0.1324
Trypanosoma brucei calmodulin, putative 0.0143 0.0289 0.0851
Echinococcus granulosus calbindin 32 0.0146 0.0296 0.0296
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0027 0.0027
Echinococcus granulosus cathepsin l cysteine peptidase 0.0571 0.1324 0.1324
Echinococcus granulosus cysteine protease 0.0353 0.0797 0.0797
Echinococcus multilocularis cathepsin L cysteine protease 0.0571 0.1324 0.1324
Toxoplasma gondii cathepsin CPC2 0.0205 0.0438 0.1291
Trypanosoma brucei mitochondrial calcium uptake 1 0.0143 0.0289 0.0851
Entamoeba histolytica grainin, putative 0.0146 0.0296 0.2054
Entamoeba histolytica calpain large subunit domain III containing protein 0.0618 0.1439 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0353 0.0797 0.0797
Echinococcus multilocularis programmed cell death protein 0.0147 0.0298 0.0298
Giardia lamblia Cathepsin B precursor 0.0205 0.0438 0.1291
Schistosoma mansoni hypothetical protein 0.0143 0.0289 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.1324 0.39
Echinococcus granulosus Tolloid protein 1 0.0047 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0422 0.0965 0.0965
Entamoeba histolytica cysteine proteinase, putative 0.0571 0.1324 0.9205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.1324 0.39
Trichomonas vaginalis calpain, putative 0.0257 0.0564 0.1662
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0148 0.0301 0.0301
Entamoeba histolytica calmodulin, putative 0.0143 0.0289 0.2009
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0013 0.0013
Trypanosoma brucei calpain-like protein, putative 0.0875 0.2061 0.607
Trichomonas vaginalis conserved hypothetical protein 0.0205 0.0438 0.1291
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.1662
Trichomonas vaginalis calmodulin, putative 0.0143 0.0289 0.0851
Loa Loa (eye worm) hypothetical protein 0.0205 0.0438 0.0438
Toxoplasma gondii centrin 0.0143 0.0289 0.0851
Trypanosoma brucei Component of motile flagella 41 0.0143 0.0289 0.0851
Echinococcus multilocularis calpain 0.0875 0.2061 0.2061
Leishmania major phospholipase c-like protein 0.0143 0.0289 0.0851
Brugia malayi cathepsin Z-like cysteine proteinase 0.0205 0.0438 0.0438
Giardia lamblia Hypothetical protein 0.0205 0.0438 0.1291
Entamoeba histolytica cysteine protease, putative 0.0353 0.0797 0.5543
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0571 0.1324 0.39
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0205 0.0438 0.1291
Schistosoma mansoni calpain-7 (C02 family) 0.0875 0.2061 0.2061
Toxoplasma gondii cathepsin CPL 0.0571 0.1324 0.39
Trypanosoma cruzi Aph-1 protein, putative 0.0097 0.0177 0.0177
Echinococcus multilocularis cysteine protease 0.0571 0.1324 0.1324
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0571 0.1324 0.39
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0249 0.0544 0.0544
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0875 0.2061 0.607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0571 0.1324 0.39
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.1662
Entamoeba histolytica calmodulin, putative 0.0143 0.0289 0.2009
Echinococcus multilocularis centrin 2 0.0143 0.0289 0.0289
Leishmania major hypothetical protein, conserved 0.0035 0.0027 0.008
Giardia lamblia Cysteine protease 0.0205 0.0438 0.1291
Echinococcus granulosus serotonin transporter 0.0073 0.0119 0.0119
Mycobacterium tuberculosis Conserved protein 0.0035 0.0027 0.0558
Trypanosoma cruzi cruzipain precursor, putative 0.0571 0.1324 0.1324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.1324 0.39
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0257 0.0564 0.1662
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.005 0.005
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1426 0.3395 0.3395
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0571 0.1324 0.1324
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0205 0.0438 0.2126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0571 0.1324 0.39
Trypanosoma cruzi cruzipain precursor, putative 0.0148 0.0301 0.0301
Echinococcus granulosus calpain A 0.0875 0.2061 0.2061
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0257 0.0564 0.1662
Mycobacterium ulcerans lipase LipD 0.0035 0.0027 0.5
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0257 0.0564 0.1662
Trypanosoma brucei caltractin, putative 0.0147 0.0298 0.0878
Echinococcus multilocularis cathepsin b 0.4153 1 1
Schistosoma mansoni cathepsin S (C01 family) 0.0205 0.0438 0.0438
Trichomonas vaginalis calmodulin, putative 0.0147 0.0298 0.0878
Leishmania major cathepsin L-like protease 0.0571 0.1324 0.39
Echinococcus multilocularis calumenin 0.0146 0.0296 0.0296
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0146 0.0296 0.0296
Plasmodium falciparum serine repeat antigen 8 0.0205 0.0438 0.3309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.1324 0.39
Entamoeba histolytica cysteine proteinase, putative 0.0353 0.0797 0.5543
Giardia lamblia Cathepsin B precursor 0.0205 0.0438 0.1291
Giardia lamblia Cathepsin B precursor 0.0205 0.0438 0.1291
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0143 0.0289 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.1324 0.39
Giardia lamblia Cathepsin B precursor 0.0205 0.0438 0.1291
Trichomonas vaginalis conserved hypothetical protein 0.0257 0.0564 0.1662
Plasmodium vivax vivapain-2 0.0571 0.1324 0.6425
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.1662
Trichomonas vaginalis calcineurin B subunit, putative 0.0143 0.0289 0.0851
Plasmodium vivax calpain, putative 0.0875 0.2061 1
Leishmania major centrin, putative 0.0143 0.0289 0.0851
Onchocerca volvulus 0.0143 0.0289 0.0832
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0027 0.0558
Brugia malayi Papain family cysteine protease containing protein 0.0205 0.0438 0.0438
Toxoplasma gondii preprocathepsin c precursor, putative 0.0205 0.0438 0.1291
Trichomonas vaginalis centrin, putative 0.0143 0.0289 0.0851
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0205 0.0438 0.0438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.1324 0.39
Brugia malayi Papain family cysteine protease containing protein 0.0205 0.0438 0.0438
Echinococcus granulosus cathepsin L 0.0205 0.0438 0.0438
Echinococcus granulosus calumenin 0.0146 0.0296 0.0296
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0013 0.0039
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0073 0.0119 0.0119
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0027 0.0558
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0257 0.0564 0.1662
Brugia malayi cathepsin L-like precursor 0.0422 0.0965 0.0965
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0353 0.0797 0.0797
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0257 0.0564 0.1662
Loa Loa (eye worm) hypothetical protein 0.0571 0.1324 0.1324
Trichomonas vaginalis esterase, putative 0.0035 0.0027 0.008
Schistosoma mansoni calmodulin 0.0143 0.0289 0.0289
Brugia malayi Papain family cysteine protease containing protein 0.0571 0.1324 0.1324
Entamoeba histolytica grainin 2 0.0147 0.0298 0.2073
Entamoeba histolytica calpain family cysteine protease, putative 0.0257 0.0564 0.3923
Brugia malayi calpain family protein 1 0.2334 0.5595 0.5595
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.005 0.005
Trypanosoma brucei centrin, putative 0.0143 0.0289 0.0851
Giardia lamblia Cysteine protease 0.0205 0.0438 0.1291
Loa Loa (eye worm) hypothetical protein 0.0148 0.0301 0.0301
Leishmania major cathepsin L-like protease 0.0571 0.1324 0.39
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.0564
Echinococcus multilocularis EF hand domain containing family member A2 0.0143 0.0289 0.0289
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0205 0.0438 0.0438
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0205 0.0438 0.0438
Trichomonas vaginalis calmodulin, putative 0.0143 0.0289 0.0851
Giardia lamblia Cathepsin B precursor 0.1426 0.3395 1
Giardia lamblia Encystation-specific protease 0.0205 0.0438 0.1291
Trypanosoma brucei calpain-like protein, putative 0.0875 0.2061 0.607
Echinococcus multilocularis calpain A 0.248 0.5948 0.5948
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0205 0.0438 0.1291
Loa Loa (eye worm) EF hand family protein 0.0143 0.0289 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.0438 0.1291
Entamoeba histolytica cysteine proteinase, putative 0.0353 0.0797 0.5543
Leishmania major centrin, putative,caltractin, putative 0.0143 0.0289 0.0851
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4153 1 1
Trichomonas vaginalis calmodulin-2, putative 0.0143 0.0289 0.0851
Trichomonas vaginalis calpain, putative 0.0257 0.0564 0.1662
Trypanosoma cruzi calmodulin, putative 0.0143 0.0289 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0205 0.0438 0.1291
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1426 0.3395 0.3395
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.1662
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0205 0.0438 0.1291
Entamoeba histolytica hypothetical protein, conserved 0.0146 0.0296 0.2054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0205 0.0438 0.0438
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4153 1 1
Plasmodium vivax vivapain-1 0.0353 0.0797 0.3869
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0257 0.0564 0.0564
Giardia lamblia Cathepsin B precursor 0.0205 0.0438 0.1291
Brugia malayi calcium-binding protein 0.0143 0.0289 0.0289
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.1662
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0061 0.0061
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0353 0.0797 0.0797
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0027 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0571 0.1324 0.39
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0353 0.0797 0.2349
Plasmodium vivax vivapain-2 0.0571 0.1324 0.6425
Loa Loa (eye worm) hypothetical protein 0.0073 0.0119 0.0119
Schistosoma mansoni gamma-secretase subunit aph-1 0.0249 0.0544 0.0544
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.0438 0.1291
Loa Loa (eye worm) hypothetical protein 0.0034 0.0023 0.0023
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0205 0.0438 0.2126
Echinococcus multilocularis calmodulin 0.0143 0.0289 0.0289
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0027 0.0558
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.005 0.005
Trypanosoma cruzi centrin, putative 0.0147 0.0298 0.0298
Loa Loa (eye worm) AStacin protease 0.0029 0.0013 0.0013
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0257 0.0564 0.0564
Echinococcus multilocularis geminin 0.0175 0.0366 0.0366
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0257 0.0564 0.1662
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0027 0.5
Echinococcus granulosus cathepsin b 0.4153 1 1
Echinococcus multilocularis neuronal calcium sensor 0.0143 0.0289 0.0289
Trypanosoma cruzi kinesin, putative 0.0618 0.1439 0.1439
Brugia malayi Cathepsin L-like precursor 0.0422 0.0965 0.0965
Leishmania major cathepsin L-like protease 0.0571 0.1324 0.39
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.0564
Schistosoma mansoni hypothetical protein 0.0034 0.0023 0.0023
Plasmodium vivax vivapain-3 0.0353 0.0797 0.3869
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0143 0.0289 0.0851
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0422 0.0965 0.0965
Entamoeba histolytica cysteine protease, putative 0.0353 0.0797 0.5543
Trypanosoma cruzi kinesin, putative 0.0618 0.1439 0.1439
Trichomonas vaginalis calmodulin, putative 0.0143 0.0289 0.0851
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0205 0.0438 0.1291
Trichomonas vaginalis myosin light chain 1, putative 0.0143 0.0289 0.0851
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0205 0.0438 0.1291
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0205 0.0438 0.1291
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0047 0.0055 0.0055
Schistosoma mansoni rab 0.0143 0.0289 0.0289
Trichomonas vaginalis calpain, putative 0.0257 0.0564 0.1662
Entamoeba histolytica cysteine protease, putative 0.0353 0.0797 0.5543
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0205 0.0438 0.3309
Onchocerca volvulus 0.0571 0.1324 0.3811
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.0965 0.2842
Plasmodium falciparum serine repeat antigen 9 0.0205 0.0438 0.3309
Trypanosoma cruzi cysteine peptidase, putative 0.0148 0.0301 0.0301
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0013 0.0013
Trypanosoma cruzi cysteine peptidase, putative 0.0571 0.1324 0.1324
Giardia lamblia Cathepsin L precursor 0.0205 0.0438 0.1291
Loa Loa (eye worm) hypothetical protein 0.0257 0.0564 0.0564
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0571 0.1324 0.39
Schistosoma mansoni reticulocalbin 0.0143 0.0289 0.0289
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0047 0.0055 0.0055
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.0486 1
Onchocerca volvulus 0.0029 0.0013 0.0038
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0205 0.0438 0.0438
Brugia malayi calpain D 0.0257 0.0564 0.0564
Brugia malayi Pre-SET motif family protein 0.0029 0.0013 0.0013
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0257 0.0564 0.0564
Brugia malayi cathepsin F-like cysteine proteinase 0.0205 0.0438 0.0438
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0571 0.1324 0.39
Entamoeba histolytica cysteine protease, putative 0.0571 0.1324 0.9205
Echinococcus multilocularis calcium uptake protein 1 0.0146 0.0296 0.0296
Echinococcus multilocularis programmed cell death protein 0.0147 0.0298 0.0298
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0143 0.0289 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.0438 0.1291
Giardia lamblia Cathepsin B precursor 0.1426 0.3395 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0205 0.0438 0.0438
Trichomonas vaginalis calcium binding protein, putative 0.0143 0.0289 0.0851
Echinococcus granulosus cathepsin L cysteine proteinase 0.0571 0.1324 0.1324
Trichomonas vaginalis calcium binding protein, putative 0.0143 0.0289 0.0851
Giardia lamblia Cathepsin B precursor 0.1426 0.3395 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0875 0.2061 0.607
Trypanosoma brucei calmodulin, putative 0.0146 0.0296 0.087
Trypanosoma cruzi I/6 autoantigen, putative 0.0143 0.0289 0.0289
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0205 0.0438 0.0438
Entamoeba histolytica cysteine protease, putative 0.0353 0.0797 0.5543
Giardia lamblia Cathepsin L precursor 0.0205 0.0438 0.1291
Trichomonas vaginalis centrin, putative 0.0143 0.0289 0.0851
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.4153 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.1324 0.39
Leishmania major i/6 autoantigen-like protein 0.0143 0.0289 0.0851
Entamoeba histolytica cysteine protease, putative 0.0353 0.0797 0.5543
Plasmodium falciparum centrin-1 0.0143 0.0289 0.2183
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0013 0.0013
Onchocerca volvulus 0.0571 0.1324 0.3811
Echinococcus granulosus calpain 5 0.0875 0.2061 0.2061
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.1662
Entamoeba histolytica cysteine protease, putative 0.0353 0.0797 0.5543
Trypanosoma cruzi cysteine protease, putative 0.0353 0.0797 0.0797
Leishmania major cysteine peptidase A (CPA) 0.0571 0.1324 0.39
Echinococcus multilocularis cathepsin b 0.4153 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0061 0.0061
Plasmodium vivax SET domain protein, putative 0.0029 0.0013 0.0063
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0257 0.0564 0.1662
Plasmodium falciparum calpain 0.0257 0.0564 0.4262
Brugia malayi Pre-SET motif family protein 0.0205 0.0438 0.0438
Mycobacterium tuberculosis Conserved protein 0.0035 0.0027 0.0558
Onchocerca volvulus Cathepsin L homolog 0.0571 0.1324 0.3811
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1426 0.3395 1
Entamoeba histolytica cysteine protease, putative 0.0353 0.0797 0.5543
Loa Loa (eye worm) beta-lactamase 0.0035 0.0027 0.0027
Loa Loa (eye worm) norepinephrine transporter 0.0073 0.0119 0.0119
Leishmania major protein kinase, putative 0.0143 0.0289 0.0851
Leishmania major cathepsin L-like protease 0.0571 0.1324 0.39
Trypanosoma cruzi Aph-1 protein, putative 0.0097 0.0177 0.0177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0571 0.1324 0.39
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0875 0.2061 0.2061
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0205 0.0438 0.2126
Loa Loa (eye worm) cathepsin B 0.1426 0.3395 0.3395
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0027
Echinococcus granulosus centrin 2 0.0143 0.0289 0.0289
Echinococcus multilocularis cathepsin L cysteine protease 0.0571 0.1324 0.1324
Echinococcus granulosus calpain 0.0875 0.2061 0.2061
Plasmodium vivax unspecified product 0.0205 0.0438 0.2126
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0061 0.0061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.005 0.005
Brugia malayi cathepsin L precursor 0.0205 0.0438 0.0438
Mycobacterium ulcerans beta-lactamase 0.0035 0.0027 0.5
Onchocerca volvulus 0.0035 0.0027 0.0078
Trypanosoma cruzi I/6 autoantigen, putative 0.0143 0.0289 0.0289
Toxoplasma gondii calmodulin CAM1 0.0146 0.0296 0.087
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0027
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0027 0.5
Entamoeba histolytica cysteine protease, putative 0.0353 0.0797 0.5543
Echinococcus granulosus calpain A 0.248 0.5948 0.5948
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0571 0.1324 0.39
Trypanosoma brucei I/6 autoantigen 0.0143 0.0289 0.0851
Plasmodium falciparum serine repeat antigen 6 0.0205 0.0438 0.3309
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0205 0.0438 0.0438
Schistosoma mansoni cathepsin C 0.0205 0.0438 0.0438
Brugia malayi Papain family cysteine protease containing protein 0.0353 0.0797 0.0797
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.1662
Schistosoma mansoni cathepsin F (C01 family) 0.0422 0.0965 0.0965
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0061 0.0061
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0875 0.2061 0.2061
Schistosoma mansoni calmodulin 0.0143 0.0289 0.0289
Echinococcus granulosus geminin 0.0175 0.0366 0.0366
Schistosoma mansoni cathepsin B (C01 family) 0.0205 0.0438 0.0438
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0875 0.2061 0.2061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0571 0.1324 0.39
Onchocerca volvulus Cathepsin F homolog 0.0571 0.1324 0.3811
Entamoeba histolytica cysteine protease, putative 0.0205 0.0438 0.3046
Entamoeba histolytica cysteine protease, putative 0.0353 0.0797 0.5543
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0571 0.1324 0.39
Loa Loa (eye worm) programmed cell death protein 6 0.0146 0.0296 0.0296
Trypanosoma cruzi major cysteine proteinase, putative 0.0205 0.0438 0.0438
Trichomonas vaginalis calcium binding protein, putative 0.0143 0.0289 0.0851
Onchocerca volvulus 0.0571 0.1324 0.3811
Plasmodium falciparum cysteine proteinase falcipain 3 0.0571 0.1324 1
Brugia malayi Papain family cysteine protease containing protein 0.0205 0.0438 0.0438
Schistosoma mansoni neuronal calcium sensor 0.0143 0.0289 0.0289
Onchocerca volvulus 0.0035 0.0027 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.1324 0.39
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0875 0.2061 0.2061
Echinococcus granulosus cathepsin L 0.0353 0.0797 0.0797
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0143 0.0289 0.0851
Schistosoma mansoni cathepsin s 0.0148 0.0301 0.0301
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0205 0.0438 0.0438
Loa Loa (eye worm) calpain 5 0.0618 0.1439 0.1439
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0257 0.0564 0.1662
Toxoplasma gondii EFHC1, putative 0.0143 0.0289 0.0851
Schistosoma mansoni centrin-related 0.0143 0.0289 0.0289
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0571 0.1324 0.39
Entamoeba histolytica cysteine protease, putative 0.0205 0.0438 0.3046
Trichomonas vaginalis calcium binding protein, putative 0.0147 0.0298 0.0878
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.0438 0.0438
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0205 0.0438 0.1291
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0205 0.0438 0.1291
Brugia malayi Cathepsin L-like precursor 0.0571 0.1324 0.1324
Plasmodium vivax serine-repeat antigen (SERA) 0.0205 0.0438 0.2126
Schistosoma mansoni calpain-7 (C02 family) 0.0875 0.2061 0.2061
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1426 0.3395 1
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0143 0.0289 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0289 0.0851
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0027 0.0558
Entamoeba histolytica cysteine proteinase 1, putative 0.0353 0.0797 0.5543
Trypanosoma brucei protein I/6 0.0143 0.0289 0.0851
Loa Loa (eye worm) cysteine protease 0.0571 0.1324 0.1324
Trypanosoma cruzi major cysteine proteinase, putative 0.0205 0.0438 0.0438
Plasmodium falciparum serine repeat antigen 3 0.0205 0.0438 0.3309
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0205 0.0438 0.3309
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0073 0.0119 0.0119
Toxoplasma gondii ABC1 family protein 0.0035 0.0027 0.008
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0143 0.0289 0.0289
Plasmodium vivax unspecified product 0.0148 0.0301 0.1461
Entamoeba histolytica cysteine proteinase, putative 0.0353 0.0797 0.5543
Loa Loa (eye worm) hypothetical protein 0.4153 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.005 0.005
Giardia lamblia Hypothetical protein 0.0205 0.0438 0.1291
Loa Loa (eye worm) hypothetical protein 0.0045 0.005 0.005
Giardia lamblia Cathepsin L-like protease 0.0205 0.0438 0.1291
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0571 0.1324 0.1324
Echinococcus multilocularis calpain family protein 1, d 0.1716 0.4098 0.4098
Entamoeba histolytica cysteine protease, putative 0.0205 0.0438 0.3046
Trypanosoma cruzi cysteine proteinase, putative 0.0353 0.0797 0.0797
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0205 0.0438 0.2126
Brugia malayi Cathepsin L-like precursor 0.0571 0.1324 0.1324
Giardia lamblia Cathepsin L precursor 0.0205 0.0438 0.1291
Trypanosoma brucei calpain-like protein, putative 0.0875 0.2061 0.607
Entamoeba histolytica cysteine protease, putative 0.0353 0.0797 0.5543
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0013 0.0013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.005 0.005
Brugia malayi beta-lactamase family protein 0.0035 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.0205 0.0438 0.3046
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0027
Leishmania major hypothetical protein, conserved 0.0143 0.0289 0.0851
Plasmodium falciparum cysteine proteinase falcipain 1 0.0353 0.0797 0.6021
Echinococcus multilocularis cathepsin L 0.0353 0.0797 0.0797
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2477 0.5942 0.5942
Entamoeba histolytica cysteine proteinase 2 0.0353 0.0797 0.5543
Onchocerca volvulus 0.0571 0.1324 0.3811
Onchocerca volvulus 0.0035 0.0027 0.0078
Trypanosoma brucei calpain, putative 0.0257 0.0564 0.1662
Loa Loa (eye worm) serotonin transporter b 0.0073 0.0119 0.0119
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0143 0.0289 0.0289
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0875 0.2061 0.2061
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0143 0.0289 0.0289
Leishmania major calmodulin-like protein 0.0143 0.0289 0.0851
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0571 0.1324 0.39
Trichomonas vaginalis calmodulin, putative 0.0143 0.0289 0.0851
Leishmania major cathepsin L-like protease 0.0571 0.1324 0.39
Entamoeba histolytica protein kinase, putative 0.0618 0.1439 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0301 0.0301
Onchocerca volvulus 0.0233 0.0507 0.1458
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.0564
Loa Loa (eye worm) calpain family protein 1 0.2334 0.5595 0.5595
Brugia malayi Papain family cysteine protease containing protein 0.0353 0.0797 0.0797
Schistosoma mansoni calpain C (C02 family) 0.0875 0.2061 0.2061
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0148 0.0301 0.0301
Trypanosoma cruzi centrin, putative 0.0147 0.0298 0.0298
Echinococcus granulosus cathepsin l1 0.0571 0.1324 0.1324
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0073 0.0119 0.0119
Trypanosoma brucei Calpain-like protein 2 0.0257 0.0564 0.1662
Loa Loa (eye worm) fibroinase 0.0571 0.1324 0.1324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.1324 0.39
Brugia malayi Cathepsin L-like cysteine proteinase 0.0422 0.0965 0.0965
Plasmodium vivax serine-repeat antigen (SERA) 0.0205 0.0438 0.2126
Echinococcus granulosus EF hand domain containing family member A2 0.0143 0.0289 0.0289
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0571 0.1324 1
Echinococcus granulosus neuronal calcium sensor 0.0143 0.0289 0.0289
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0205 0.0438 0.3046
Onchocerca volvulus 0.0146 0.0296 0.085
Trypanosoma brucei Calpain-like protein 1.1 0.0257 0.0564 0.1662
Giardia lamblia Cathepsin L precursor 0.0205 0.0438 0.1291
Trypanosoma cruzi cysteine peptidase, putative 0.0571 0.1324 0.1324
Plasmodium falciparum serine repeat antigen 2 0.0205 0.0438 0.3309
Schistosoma mansoni neuronal calcium sensor 0.0143 0.0289 0.0289
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.0564
Schistosoma mansoni hypothetical protein 0.0257 0.0564 0.0564
Echinococcus multilocularis gamma secretase subunit aph 1 0.0249 0.0544 0.0544
Schistosoma mansoni calpain-2 (C02 family) 0.0257 0.0564 0.0564
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0257 0.0564 0.0564
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0257 0.0564 0.0564
Leishmania major hypothetical protein, conserved 0.0257 0.0564 0.1662
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0027 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.0438 0.1291
Echinococcus multilocularis cathepsin L 0.0205 0.0438 0.0438
Leishmania major cathepsin L-like protease 0.0571 0.1324 0.39
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0027 0.0027
Leishmania major calmodulin, putative 0.0143 0.0289 0.0851
Brugia malayi calpain 5 0.0618 0.1439 0.1439
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0205 0.0438 0.1291
Echinococcus multilocularis hypothetical protein 0.0875 0.2061 0.2061
Loa Loa (eye worm) hypothetical protein 0.1716 0.4098 0.4098
Mycobacterium leprae Probable lipase LipE 0.0035 0.0027 0.5
Loa Loa (eye worm) calpain family protein 1 0.1716 0.4098 0.4098
Schistosoma mansoni hypothetical protein 0.0175 0.0366 0.0366
Entamoeba histolytica cysteine proteinase, putative 0.0422 0.0965 0.6708
Echinococcus granulosus EF HAND 1 calcium binding site 0.0143 0.0289 0.0289
Echinococcus multilocularis Tolloid protein 1 0.0047 0.0055 0.0055
Echinococcus multilocularis calpain 7 (C02 family) 0.0875 0.2061 0.2061
Brugia malayi cathepsin L-like cysteine proteinase 0.0205 0.0438 0.0438
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.4153 1 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.1662
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.1662
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0027 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0353 0.0797 0.2349
Trichomonas vaginalis set domain proteins, putative 0.0233 0.0507 0.1492
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0353 0.0797 0.2349
Loa Loa (eye worm) calpain 0.0875 0.2061 0.2061
Loa Loa (eye worm) hypothetical protein 0.2077 0.4972 0.4972
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.1662
Onchocerca volvulus 0.0073 0.0119 0.0342
Schistosoma mansoni ef hand domain family member A2 0.0143 0.0289 0.0289
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.1662
Leishmania major calmodulin, putative 0.0143 0.0289 0.0851
Onchocerca volvulus 0.1459 0.3475 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0875 0.2061 0.2061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0571 0.1324 0.39
Leishmania major calpain protease-like protein 0.0257 0.0564 0.1662
Trypanosoma brucei Aph-1 protein, putative 0.0097 0.0177 0.052
Trypanosoma brucei cysteine peptidase, putative 0.0257 0.0564 0.1662
Trypanosoma cruzi caltractin, putative 0.0143 0.0289 0.0289
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0875 0.2061 0.2061
Giardia lamblia Cysteine protease 0.0205 0.0438 0.1291
Entamoeba histolytica calcium-binding protein, putative 0.0143 0.0289 0.2009
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0205 0.0438 0.0438
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0571 0.1324 0.39
Plasmodium vivax hypothetical protein, conserved 0.0146 0.0296 0.1434
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4153 1 1
Giardia lamblia Cathepsin L precursor 0.0205 0.0438 0.1291
Schistosoma mansoni cathepsin F (C01 family) 0.0571 0.1324 0.1324
Brugia malayi EF hand family protein 0.0146 0.0296 0.0296
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0257 0.0564 0.0564
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0875 0.2061 0.607
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0143 0.0289 0.1402
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0257 0.0564 0.0564
Toxoplasma gondii cathepsin CPC1 0.0205 0.0438 0.1291
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.1662
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0257 0.0564 0.0564
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0875 0.2061 0.2061
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.1662
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0027 0.0558
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0257 0.0564 0.1662
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0027 0.5
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0875 0.2061 0.607
Loa Loa (eye worm) calpain D 0.0257 0.0564 0.0564
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0027 0.0132
Entamoeba histolytica cysteine protease, putative 0.0353 0.0797 0.5543
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0027 0.008
Trichomonas vaginalis calmodulin, putative 0.0143 0.0289 0.0851
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0027
Plasmodium vivax centrin-1, putative 0.0143 0.0289 0.1402
Echinococcus granulosus neurocalcin 0.0143 0.0289 0.0289
Brugia malayi calpain 5 0.0257 0.0564 0.0564
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0013 0.0013
Brugia malayi gamma-secretase subunit aph-1 0.0249 0.0544 0.0544
Schistosoma mansoni neuronal calcium sensor 0.0143 0.0289 0.0289
Leishmania major programmed cell death 6 protein-like protein 0.0143 0.0289 0.0851
Brugia malayi beta-lactamase 0.0035 0.0027 0.0027
Trypanosoma cruzi centrin-3 0.0147 0.0298 0.0298
Brugia malayi cathepsin F-like cysteine proteinase 0.0148 0.0301 0.0301
Brugia malayi Cathepsin L-like precursor 0.0422 0.0965 0.0965
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0205 0.0438 0.2126
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0027 0.0027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.005 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0205 0.0438 0.1291
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0027 0.0027
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0257 0.0564 0.1662
Loa Loa (eye worm) hypothetical protein 0.0143 0.0289 0.0289
Brugia malayi fibroinase precursor 0.0205 0.0438 0.0438
Brugia malayi Calmodulin-like protein 0.0143 0.0289 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.0438 0.1291
Schistosoma mansoni sodium/chloride dependent transporter 0.0073 0.0119 0.0119
Schistosoma mansoni calmodulin related calcium binding protein 0.0143 0.0289 0.0289
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0013 0.0013
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.1662
Trypanosoma cruzi conserved protein 0.0257 0.0564 0.0564
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0571 0.1324 0.39
Trypanosoma cruzi cysteine peptidase, putative 0.0571 0.1324 0.1324
Brugia malayi Cathepsin L-like precursor 0.0571 0.1324 0.1324
Toxoplasma gondii centrin, putative 0.0143 0.0289 0.0851
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0353 0.0797 0.2349
Loa Loa (eye worm) ctsf protein 0.0571 0.1324 0.1324
Giardia lamblia Cathepsin L precursor 0.0205 0.0438 0.1291
Loa Loa (eye worm) calmodulin-like protein 0.0143 0.0289 0.0289
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0143 0.0289 0.0289
Brugia malayi Cathepsin L-like precursor 0.0571 0.1324 0.1324
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0205 0.0438 0.1291
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0205 0.0438 0.2126
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.2477 0.5942 0.5942
Loa Loa (eye worm) hypothetical protein 0.0205 0.0438 0.0438
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.005 0.005
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0027 0.008
Leishmania major kinesin, putative 0.0618 0.1439 0.4237
Entamoeba histolytica calcium binding family protein 0.0143 0.0289 0.2009
Echinococcus multilocularis neurocalcin 0.0143 0.0289 0.0289
Entamoeba histolytica cysteine protease, putative 0.0353 0.0797 0.5543
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0143 0.0289 0.2009
Echinococcus multilocularis serotonin transporter 0.0073 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0205 0.0438 0.0438
Toxoplasma gondii cathepsin B 0.1426 0.3395 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0027 0.0558
Schistosoma mansoni mitochondrial solute carrier 0.0143 0.0289 0.0289
Toxoplasma gondii calcium-dependent protein kinase 0.0146 0.0296 0.087
Entamoeba histolytica cysteine proteinase, putative 0.0353 0.0797 0.5543
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0353 0.0797 0.0797
Trypanosoma brucei centrin, putative 0.0143 0.0289 0.0851
Loa Loa (eye worm) hypothetical protein 0.0422 0.0965 0.0965
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0571 0.1324 0.39
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0027 0.008
Entamoeba histolytica cysteine protease, putative 0.0353 0.0797 0.5543
Leishmania major hypothetical protein, conserved 0.0146 0.0296 0.087
Brugia malayi Cathepsin L-like precursor 0.0571 0.1324 0.1324
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0205 0.0438 0.2126
Toxoplasma gondii hypothetical protein 0.0257 0.0564 0.1662
Onchocerca volvulus Cathepsin L homolog 0.0571 0.1324 0.3811
Leishmania major calmodulin-like protein 0.0143 0.0289 0.0851
Schistosoma mansoni neuronal calcium sensor 0.0143 0.0289 0.0289
Echinococcus multilocularis cysteine protease 0.0571 0.1324 0.1324
Echinococcus multilocularis calbindin 32 0.0146 0.0296 0.0296
Trypanosoma brucei hypothetical protein 0.0257 0.0564 0.1662
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.1662
Echinococcus multilocularis calmodulin 0.0143 0.0289 0.0289
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0143 0.0289 0.2009
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0205 0.0438 0.0438
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0571 0.1324 0.39
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0143 0.0289 0.0851
Entamoeba histolytica cysteine protease, putative 0.0205 0.0438 0.3046
Echinococcus granulosus EF hand domain containing family member A2 0.0146 0.0296 0.0296
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0205 0.0438 0.0438
Plasmodium falciparum serine repeat antigen 7 0.0205 0.0438 0.3309
Echinococcus granulosus calcium uptake protein 1 0.0146 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0027
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0205 0.0438 0.0438
Trypanosoma brucei hypothetical protein, conserved 0.0143 0.0289 0.0851
Leishmania major cathepsin L-like protease 0.0571 0.1324 0.39
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0205 0.0438 0.0438
Plasmodium falciparum serine repeat antigen 1 0.0205 0.0438 0.3309
Plasmodium falciparum serine repeat antigen 5 0.0205 0.0438 0.3309
Trypanosoma brucei calpain, putative 0.0257 0.0564 0.1662
Schistosoma mansoni calpain (C02 family) 0.0875 0.2061 0.2061
Echinococcus granulosus programmed cell death protein 0.0147 0.0298 0.0298
Trypanosoma brucei Calpain-like protein 1.2 0.0257 0.0564 0.1662
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0205 0.0438 0.2126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0422 0.0965 0.2842
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0205 0.0438 0.1291
Onchocerca volvulus Cathepsin L homolog 0.0205 0.0438 0.1261
Giardia lamblia Cathepsin L-like protease 0.0205 0.0438 0.1291
Trypanosoma cruzi cysteine proteinase, putative 0.0353 0.0797 0.0797
Trichomonas vaginalis calmodulin, putative 0.0143 0.0289 0.0851
Trypanosoma brucei antigen, putative 0.0875 0.2061 0.607
Onchocerca volvulus 0.0571 0.1324 0.3811
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.1662
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0205 0.0438 0.1291
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0027 0.0027
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0257 0.0564 0.1662
Brugia malayi programmed cell death protein 6 0.0143 0.0289 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.0438 0.1291
Schistosoma mansoni centrin 0.0143 0.0289 0.0289
Onchocerca volvulus 0.0571 0.1324 0.3811
Onchocerca volvulus 0.0571 0.1324 0.3811
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.1324 0.39
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0289 0.0851
Echinococcus granulosus calpain 7 C02 family 0.0875 0.2061 0.2061
Echinococcus granulosus cathepsin l1 0.0422 0.0965 0.0965
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2477 0.5942 0.5942
Mycobacterium tuberculosis Conserved protein 0.0035 0.0027 0.0558
Trypanosoma cruzi cysteine peptidase, putative 0.0353 0.0797 0.0797
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0205 0.0438 0.0438
Loa Loa (eye worm) solute carrier family 6 member 4 0.0073 0.0119 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0205 0.0438 0.1291
Trypanosoma cruzi calmodulin, putative 0.0143 0.0289 0.0289
Schistosoma mansoni hypothetical protein 0.0143 0.0289 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0571 0.1324 0.39
Entamoeba histolytica cysteine proteinase, putative 0.0571 0.1324 0.9205
Entamoeba histolytica cysteine protease, putative 0.0205 0.0438 0.3046
Brugia malayi calpain family protein 1 0.2334 0.5595 0.5595
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0571 0.1324 0.1324
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0143 0.0289 0.0289
Trypanosoma brucei kinesin, putative 0.0618 0.1439 0.4237
Leishmania major cathepsin L-like protease 0.0571 0.1324 0.39
Schistosoma mansoni reticulocalbin 0.0146 0.0296 0.0296
Toxoplasma gondii troponin c, isotype gamma, putative 0.0143 0.0289 0.0851
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0146 0.0296 0.0296
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0027 0.0558
Trypanosoma brucei Calpain-like protein CALP1.3 0.0257 0.0564 0.1662
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.001 0.001
Trichomonas vaginalis hypothetical protein 0.0257 0.0564 0.1662
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0875 0.2061 0.607
Loa Loa (eye worm) hypothetical protein 0.0148 0.0301 0.0301
Plasmodium falciparum serine repeat antigen 4 0.0205 0.0438 0.3309
Brugia malayi beta-lactamase family protein 0.0035 0.0027 0.0027
Schistosoma mansoni cathepsin F (C01 family) 0.0571 0.1324 0.1324
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0023 0.0023
Echinococcus granulosus gamma secretase subunit aph 1 0.0249 0.0544 0.0544
Echinococcus granulosus cathepsin b 0.4153 1 1
Schistosoma mansoni hypothetical protein 0.0175 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.0073 0.0119 0.0119
Plasmodium vivax unspecified product 0.0353 0.0797 0.3869
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0143 0.0289 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0571 0.1324 0.39
Trichomonas vaginalis calmodulin, putative 0.0143 0.0289 0.0851
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0257 0.0564 0.0564
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0143 0.0289 0.0851
Trypanosoma brucei centrin-3 0.0147 0.0298 0.0878
Leishmania major calpain family cysteine protease-like protein 0.0257 0.0564 0.1662
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0013 0.0013
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0875 0.2061 0.2061
Leishmania major calcineurin B subunit, putative 0.0143 0.0289 0.0851

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 8 % Percent inhibition of [3H]-DA uptake in rat brain tissue at 100 uM ChEMBL. 15743177
Inhibition (functional) = 15 % Percent inhibition of [3H]-DAMGO binding to rat brain mu-opioid receptor at 100 uM ChEMBL. 15743177
Inhibition (binding) = 45 % Percent inhibition of [3H]WIN35,428 binding to rat Dopamine transporter at 100 uM ChEMBL. 15743177
Ki (binding) = 10.1 uM Inhibition of [3H]-paroxetine binding to rat serotonin transporter ChEMBL. 15743177
Ki (binding) = 101.4 uM Inhibition of [3H]-nisoxetine binding to rat norepinephrine transporter at 10 uM ChEMBL. 15743177

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.